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        <name evidence="15" type="ORF">H671_21206</name>
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    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative pheromone receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ERE59543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027398672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HTP0"/>
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    <dbReference type="KEGG" id="cge:100771714"/>
    <dbReference type="OrthoDB" id="9606139at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
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        <property type="component" value="Unplaced"/>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Vomeronasal type-1 receptor"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ERE59543.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027254473.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35092" checksum="8641D1F06B73B5A2" modified="2014-09-03" version="1">MESRNLAIGILISLQSALGILGNVSFLFQYLLVYYNEHTLKTVDLILIHVFTSNSLIILSTGVPQIMRMFEWKRFFNDVECKLILYIQRLCRSLSITSTCLLSVFQAITISPNVSYCKELKIKLPKYVHLSISFLWILYMIVNMVFPMYTATKSNSKNKTKMRNFEFCPALNQDKIVESLYTVFWVFPEVLFSILIVCSSISMIVILYEHKKRVQCILSTHASTRISPESRATQNILVLVCTFLAFYTISSILQGYMALSFNLNSWLVNITGIISMCFPTLSPFVMSHESIISGFCFSCIRNRKGK</sequence>
</entry>
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    <accession>A0A061HZC8</accession>
    <name>A0A061HZC8_CRIGR</name>
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        <recommendedName>
            <fullName evidence="32">NADPH oxidase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">CGD91-phox</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Cytochrome b(558) subunit beta</fullName>
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        <alternativeName>
            <fullName evidence="33">Cytochrome b-245 heavy chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Heme-binding membrane glycoprotein gp91phox</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Neutrophil cytochrome b 91 kDa polypeptide</fullName>
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        <alternativeName>
            <fullName evidence="25">gp91-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">gp91-phox</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">p22 phagocyte B-cytochrome</fullName>
        </alternativeName>
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        <name evidence="37 40" type="primary">LOC100760802</name>
        <name evidence="36" type="ORF">H671_xg19863</name>
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    <organism evidence="36 38">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="40" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="40">17A/GY</strain>
            <tissue evidence="40">Liver</tissue>
        </source>
    </reference>
    <reference evidence="37" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="31">Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS.</text>
    </comment>
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        <reaction evidence="30">
            <text>NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63180"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE683010">
        <property type="protein sequence ID" value="ERE65882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305927.1">
        <property type="nucleotide sequence ID" value="XM_035450036.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315529.1">
        <property type="nucleotide sequence ID" value="XM_035459638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HZC8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017020.1">
        <property type="protein sequence ID" value="ENSCGRP00001012785.1"/>
        <property type="gene ID" value="ENSCGRG00001014092.1"/>
    </dbReference>
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        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
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                <person name="Grillari J."/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="23" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
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                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1-&gt;2)- beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32175"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17292"/>
            <dbReference type="ChEBI" id="CHEBI:28743"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="2.4.1.69"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:32176"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50668"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:133510"/>
            <dbReference type="EC" id="2.4.1.344"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a ganglioside GA1 + GDP-beta-L-fucose = a ganglioside Fuc-GA1 + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48320"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:88069"/>
            <dbReference type="ChEBI" id="CHEBI:90262"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:48321"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:82639"/>
            <dbReference type="ChEBI" id="CHEBI:90189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:48293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48304"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17006"/>
            <dbReference type="ChEBI" id="CHEBI:28691"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>beta-D-galactosyl-(1-&gt;3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-D-galactosamine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:84728"/>
            <dbReference type="ChEBI" id="CHEBI:546807"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:62965"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 19">Golgi apparatus</location>
            <location evidence="5 19">Golgi stack membrane</location>
            <topology evidence="5 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="EMBL" id="KE680915">
        <property type="protein sequence ID" value="ERE71128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302518.1">
        <property type="nucleotide sequence ID" value="XM_035446627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I440"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009130.1">
        <property type="protein sequence ID" value="ENSCGRP00001005890.1"/>
        <property type="gene ID" value="ENSCGRG00001007818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757047"/>
    <dbReference type="KEGG" id="cge:100757047"/>
    <dbReference type="CTD" id="2523"/>
    <dbReference type="GeneTree" id="ENSGT00390000001450"/>
    <dbReference type="OrthoDB" id="3226at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021772">
        <property type="term" value="P:olfactory bulb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904906">
        <property type="term" value="P:positive regulation of endothelial cell-matrix adhesion via fibronectin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903672">
        <property type="term" value="P:positive regulation of sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001936">
        <property type="term" value="P:regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF4">
        <property type="entry name" value="GALACTOSIDE ALPHA-(1,2)-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 19 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ERE71128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035302518.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42630" checksum="F7428ACC61ED4409" modified="2014-09-03" version="1">MWTPSRRQLCLAFLLVCVLSTGSFFFHLYGGNFFGNELTLSILCPDYHLLKSPVAMVCLPHPLQTFNASPSCPRQSSSLSGTWTITPAGRFGNQMGQYATLLALAQLNGRPAFIQPEMHATLAPVFRISLPVLDPEVDSLTPWQHLVLHDWMSEEYSHLQDPFLKLSGFPCSWTFFHHLREQIRKEFTLHDHLREGAQHLLSGLRLGPWSIRPHTFVGVHVRRGDYLEVMPNRWKGVVGDRVYLQQAMDWFRARHKDPIFVVTSNGMEWCMENIDTSHGDVVFAGNGQESTPGKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTVYLANFTLPDSEFLKIFRPKAAFLPEWVGINADLSPLQAQVDPWESDGLLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I7T0</accession>
    <name>A0A061I7T0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Usp42</name>
        <name evidence="11" type="ORF">H671_4g11913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KE674505">
        <property type="protein sequence ID" value="ERE76345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299038.1">
        <property type="nucleotide sequence ID" value="XM_035443147.1"/>
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            <taxon>Mammalia</taxon>
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        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">17A/GY</strain>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:heparin binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="chain" id="PRO_5044538721" evidence="9">
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            <begin position="25"/>
            <end position="493"/>
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    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="36"/>
            <end position="148"/>
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    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="183"/>
            <end position="297"/>
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    <feature type="domain" description="NTR" evidence="11">
        <location>
            <begin position="366"/>
            <end position="485"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="368"/>
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    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="183"/>
            <end position="210"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004613"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035299296.1"/>
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    <sequence length="493" mass="53413" checksum="DD1CF8EDEC37F362" modified="2014-09-03" version="1">MLPAVLTSLLGPFLVAWVLPLARGQTPNYTRPVFLCGGDVTGESGYVASEGFPNLYPPNKKCIWTITVPEGQTVSLSFRVFDMELHPSCRYDALEVFAGSGTSGQRLGRFCGTFRPAPVVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTGPPPGARRKWVMDPRVEWAAWGYWDEHQFCGGRMEKAQGTLTTPNWPESDYPPGISCSWHIIAPSDQVIMLTFGKFDVEPDTYCRYDSVSVFNGAVSDDSKRLGKFCGDKAPSPISSEGNELLVQFVSDLSVTADGFSASYKTLPRDAVEKELAPSPGEDVQLGPQSRSDPKTGTGPKVKPPSKPKFQPAEKPEVSPDTQETPVAPDPPSATCPKQYKRLGTLQSNFCASSLVVTGTVKTMVRGPGEGLTVTISLLGVYKSGGLDLPSPPTDTSLKLYVPCRQMPPMKKGASYLLMGQVEENRGPILPPESFLVPYKPNQDQILNNLRKRKCPSQPRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I905</accession>
    <name>A0A061I905_CRIGR</name>
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        <alternativeName>
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        </alternativeName>
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        <name evidence="18" type="primary">Prss53</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE672699">
        <property type="protein sequence ID" value="ERE79040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_035442193.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd00190">
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000079">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
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    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
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    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
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    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
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    <dbReference type="PANTHER" id="PTHR24253:SF58">
        <property type="entry name" value="SERINE PROTEASE 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044538722" description="Serine protease 53" evidence="13">
        <location>
            <begin position="24"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="11"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="300"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE79040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035298084.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="60330" checksum="F54C5672C267BEED" modified="2014-09-03" version="1">MRQSWGPGLLIVGAVVMIEGLQAAQRACGQRGPGPPEPQEGNTLPGEWPWQASVRRQGVHICSGSLVADAWVLTAAHCFEKVATTELSSWSVVLGSLKQEGLSPGAEEVGVAALQVPKAYNHYSQGSDLALLQLTHPIAHTTLCLPQSTHHFPFGASCWATGWDQNTSDVSRTLRNLRLRLISRPTCNCLYNRLHQRLLASPARPGMLCGGAQPGVQGPCQGDSGGPVMCREPDGHWVQVGIVSFTSKCAQEDTPVLLTDMATHSSWLQAHLHGAAFLVQDPGIVESSDENSCVACGSLRTGGPQAGALSQWPWDARLKHHGKLACGGALVSEVVVLTAAHCFIGRQTLEEWSVDLGTGPEERGLKQLILHGAYTHPEGGYDVALLLLAQPVTLGPGLRPLCLPYADHQLPDGEHGWVLGLTQGAGNSYLQTVPVTVLGQMACSRQHAAPGSTGIPILPGMVCTTVVGELPQCVGLSGAPLIHEVRGTWFLAGLHSFGDTCQGPSRPAVFAALSAYEDWVSNLDWQVYFAEKPEPEAEPGSCLVNSSMCRYSLFLSSPGSHLEKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0U2UZZ5</accession>
    <name>A0A0U2UZZ5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Interferon-induced, double-stranded RNA-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Eukaryotic translation initiation factor 2-alpha kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Interferon-inducible RNA-dependent protein kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Protein kinase RNA-activated</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Tyrosine-protein kinase EIF2AK2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="primary">eIF2aK2</name>
        <name evidence="39 41" type="synonym">Eif2ak2</name>
    </gene>
    <organism evidence="38">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
            <authorList>
                <person name="Becker J."/>
                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
            </authorList>
            <dbReference type="PubMed" id="21945585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="38" key="2">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning of Chinese hamster PKR.</title>
            <authorList>
                <person name="Rothenburg S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="40" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="40">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="40" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="40">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="41" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="39" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26 42">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 42">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KT272869">
        <property type="protein sequence ID" value="ALS03808.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001315037.1">
        <property type="nucleotide sequence ID" value="NM_001328108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0U2UZZ5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027777.1">
        <property type="protein sequence ID" value="ENSCGRP00001023531.1"/>
        <property type="gene ID" value="ENSCGRG00001021739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757909"/>
    <dbReference type="KEGG" id="cge:100757909"/>
    <dbReference type="CTD" id="5610"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033689">
        <property type="term" value="P:negative regulation of osteoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902036">
        <property type="term" value="P:regulation of hematopoietic stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902033">
        <property type="term" value="P:regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900225">
        <property type="term" value="P:regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035455">
        <property type="term" value="P:response to interferon-alpha"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19903">
        <property type="entry name" value="DSRM_EIF2AK2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19904">
        <property type="entry name" value="DSRM_EIF2AK2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000045">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000536">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000251">
        <property type="entry name" value="eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044452">
        <property type="entry name" value="EIF2AK2_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044453">
        <property type="entry name" value="EIF2AK2_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF163">
        <property type="entry name" value="INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="20" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="14 33" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="34" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13 38 41" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 33" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="17 32" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="22" id="KW-0804">Transcription</keyword>
    <keyword evidence="19" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DRBM" evidence="37">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="37">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="36">
        <location>
            <begin position="254"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="34">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="35">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="35">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00075411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00076023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00076429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00078605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EMBL" id="ALS03808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="RefSeq" id="NP_001315037.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59627" checksum="CA6C30E499F29740" modified="2016-03-16" version="1">MASDTPGFYMDKLNKYHQKHKVMITYKQLHITGPPHDRRFTFQVIINGEEFPEAEGRTKQEAKNAAAQLAVERLNENKADSQTDASEGLLSGNYIGLVNSYAQKENLSVNYEQCTSNTQSPQRFCCKCKIGLKTYGIGSGATKQEAKQSAAKDAYQKLSEKSSMRVDRTSSGLSTSSSSGLSSSLSTASHFTSLSAPQSDFSEIASKNHWHSISFESPFTNGLRENKRKSGVKPSPSDVQRNKYTMDSRFNNDFEDIEEIGSGGFGQVFKAKHRIDGKTYAIKRVSCNTEKEVREVKALAALSHINIVQYHSCWLGQDYDPEHSPDRNPRRSKTQCLFIQMEFYDKGTLEQWMLNCKQRKVDNDLFLELSEQITTGVDYIHSKGLIHRDLKPCNIFLVDEKHIKIGDFGLVTSMEKDGNRTKRTGTLLYMSPEQLSLQEYGKEVDIFALGLILGELLHICITDLEKSKFFNDLRDGIFHDDIFGSKEKSLLKKLLAKKPMERPSTSEILMTLAEWKSISEIQKRHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H5N7</accession>
    <name>A0A3L7H5N7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Membrane-associated progesterone receptor component 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Pgrmc1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion outer membrane</location>
            <topology evidence="18">Single-pass membrane protein</topology>
            <orientation evidence="18">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027287742.1">
        <property type="nucleotide sequence ID" value="XM_027431941.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310154.1">
        <property type="nucleotide sequence ID" value="XM_035454263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H5N7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023947.1">
        <property type="protein sequence ID" value="ENSCGRP00001019703.1"/>
        <property type="gene ID" value="ENSCGRG00001019069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769956"/>
    <dbReference type="KEGG" id="cge:100769956"/>
    <dbReference type="CTD" id="10857"/>
    <dbReference type="GeneTree" id="ENSGT00940000160619"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140077">
        <property type="term" value="P:positive regulation of lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF23">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 27" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="73"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027287742.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21656" checksum="70763458132659EB" modified="2019-02-13" version="1">MAAEDVVATGADPSELEGGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPGAGNDNDDDEPPQLPRLKRRDFTLAELKVFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDDEDPKDENARKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H889</accession>
    <name>A0A3L7H889_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5-hydroxytryptamine (serotonin) receptor 5A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">5-hydroxytryptamine receptor 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Htr5a</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003500088.1">
        <property type="nucleotide sequence ID" value="XM_003500040.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284455.1">
        <property type="nucleotide sequence ID" value="XM_027428654.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H889"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012056.1">
        <property type="protein sequence ID" value="ENSCGRP00001007965.1"/>
        <property type="gene ID" value="ENSCGRG00001010326.1"/>
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    <dbReference type="KEGG" id="cge:100772532"/>
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    <dbReference type="OMA" id="PAVWKSI"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00518">
        <property type="entry name" value="5HT5ARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01101">
        <property type="entry name" value="5HTRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
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            <end position="338"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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            <dbReference type="RefSeq" id="XP_027284455.1"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HFT2</accession>
    <name>A0A3L7HFT2_CRIGR</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">17A/GY</strain>
        </source>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
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        </source>
    </reference>
    <reference evidence="10" key="4">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with SCIMP. Interacts with SOCS3. Interacts with DECTIN1/CLEC7A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </comment>
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    </dbReference>
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        <property type="protein sequence ID" value="ENSCGRP00001017003.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:immunological synapse"/>
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        <property type="term" value="P:defense response to protozoan"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetraspanin/Peripherin"/>
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        <property type="entry name" value="Tetraspanin_animals"/>
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        <property type="entry name" value="Tetraspanin_CS"/>
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    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF263">
        <property type="entry name" value="LEUKOCYTE ANTIGEN CD37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027276460.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34128" checksum="6E3A159BF04E921D" modified="2019-02-13" version="1">MDTCKGPPIVSLVPTYSKDPQVKMSAQESCLSLIKYLLFVFNLFFFVLGGLIFCFGTWILIDKNSFVSFVGLSFVPLQTWSKVLAVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRIRLERRVQELVLETIHSYRANPDETAAEESWDYAQFQLRCCGWHSPRDWISARTLRGNESEGPFVPCSCYNSTATNDSSGFDKLFLSQLSRLGPRAKLRQTADLCALPAKAHIYREGCAQSLRKWLHNNLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYDRLARYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HI62</accession>
    <name>A0A3L7HI62_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Axin interactor, dorsalization-associated protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Axin interaction partner and dorsalization antagonist</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Aida</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with AXIN1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AIDA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007639910.1">
        <property type="nucleotide sequence ID" value="XM_007641720.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274577.1">
        <property type="nucleotide sequence ID" value="XM_027418776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HI62"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028853.1">
        <property type="protein sequence ID" value="ENSCGRP00001024607.1"/>
        <property type="gene ID" value="ENSCGRG00001022468.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755322"/>
    <dbReference type="KEGG" id="cge:100755322"/>
    <dbReference type="CTD" id="64853"/>
    <dbReference type="OrthoDB" id="428576at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048264">
        <property type="term" value="P:determination of ventral identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.360:FF:000001">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000059">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.360">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025939">
        <property type="entry name" value="Aida_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023421">
        <property type="entry name" value="AIDA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036818">
        <property type="entry name" value="AIDA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654:SF1">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14186">
        <property type="entry name" value="Aida_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08910">
        <property type="entry name" value="Aida_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109779">
        <property type="entry name" value="Domain from hypothetical 2610208m17rik protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51911">
        <property type="entry name" value="C2_AIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 Aida-type" evidence="9">
        <location>
            <begin position="156"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027274577.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34907" checksum="B9993346874EA2EC" modified="2019-02-13" version="1">MSEVTRSLLQRWGASLRRGADFDSWGQLVEAIDEYQILARHLQKEAQAQHNDSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKLEDLKKLEPILKNILTYNKEFPFDVQPIPLRRILAPGEEENLEFEEDEEGGAGAGPPDSFSARVPGTLLPRLPSEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVHFNMDIELQKHVEKLTKGAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELYKKPTDFKRKKLQLLTKKPLYLHLHQTLHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HQ37</accession>
    <name>A0A3L7HQ37_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Leucine rich repeat and fibronectin type III, extracellular 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">Protein ELFN1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Elfn1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027269303.1">
        <property type="nucleotide sequence ID" value="XM_027413502.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HQ37"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002634.1">
        <property type="protein sequence ID" value="ENSCGRP00001002094.1"/>
        <property type="gene ID" value="ENSCGRG00001002145.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770773"/>
    <dbReference type="KEGG" id="cge:100770773"/>
    <dbReference type="CTD" id="392617"/>
    <dbReference type="GeneTree" id="ENSGT00940000161391"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="term" value="P:establishment of protein localization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:synapse assembly"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:synaptic membrane adhesion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="protein phosphatase 1 regulatory subunit 29"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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            <begin position="28"/>
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            <begin position="418"/>
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</entry>
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            <taxon>Mammalia</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
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        </source>
    </reference>
    <reference evidence="5" key="4">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="3">Belongs to the COMM domain-containing protein 3 family.</text>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027261108.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22109" checksum="99853017EA63499F" modified="2019-02-13" version="1">MELSEYVQRGFQRLADPGSFDSNAFALLLRAAFQSLLDARADEAALDHPGLKHIDPVVLKHCHAAAATYILEAGKHRVDRSTLSTYLEDCKFDQDRIEIFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHKMYQPGYLVTLNVENSDSQSYPEISFSCNMEQLQDLVGKLKDASKSLERATQL</sequence>
</entry>
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    <accession>A0A3L7IJW5</accession>
    <name>A0A3L7IJW5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein-serine/threonine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Pdk4</name>
    </gene>
    <organism evidence="13 14">
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        <name type="common">Chinese hamster</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_003506699.1">
        <property type="nucleotide sequence ID" value="XM_003506651.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245686.1">
        <property type="nucleotide sequence ID" value="XM_027389885.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IJW5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017135.1">
        <property type="protein sequence ID" value="ENSCGRP00001012900.1"/>
        <property type="gene ID" value="ENSCGRG00001014183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763413"/>
    <dbReference type="KEGG" id="cge:100763413"/>
    <dbReference type="CTD" id="5166"/>
    <dbReference type="GeneTree" id="ENSGT01030000234646"/>
    <dbReference type="OMA" id="HQENCPS"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071398">
        <property type="term" value="P:cellular response to fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000811">
        <property type="term" value="P:negative regulation of anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045124">
        <property type="term" value="P:regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042304">
        <property type="term" value="P:regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046320">
        <property type="term" value="P:regulation of fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010510">
        <property type="term" value="P:regulation of pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF22">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="245"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027245686.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46472" checksum="0B1EF09D132CE991" modified="2019-02-13" version="1">MKAARFVMRSASSLSSAGLVPREVELFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPERLVNTPSVQLVKSWYIQSLMDLVEFHEKSSEDQKVLSDFVDALIKVRNRHHNVVPTMAQGILEYKDTCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNPSHIGSIDPSCDVVAVVQDAFECAKMLCDQYYLTSPELKLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENRPSLTPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEAGDWCIPSREPKNLSKETVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2L8I9</accession>
    <name>A0A8C2L8I9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Beta-crystallin A3 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Crystallin, beta A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9 10 11" type="primary">Cryba1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9 10 11">17A/GY</strain>
            <tissue evidence="9 10 11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016819672.2">
        <property type="nucleotide sequence ID" value="XM_016964183.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282445.1">
        <property type="nucleotide sequence ID" value="XM_027426644.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282446.1">
        <property type="nucleotide sequence ID" value="XM_027426645.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282447.1">
        <property type="nucleotide sequence ID" value="XM_027426646.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2L8I9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000099.1">
        <property type="protein sequence ID" value="ENSCGRP00001000075.1"/>
        <property type="gene ID" value="ENSCGRG00001000096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107977665"/>
    <dbReference type="KEGG" id="cge:107977665"/>
    <dbReference type="CTD" id="1411"/>
    <dbReference type="GeneTree" id="ENSGT00940000159685"/>
    <dbReference type="OrthoDB" id="8688215at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000004">
        <property type="entry name" value="Crystallin beta A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000002">
        <property type="entry name" value="Crystallin, beta B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF8">
        <property type="entry name" value="BETA-CRYSTALLIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027282445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027282446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027282447.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25848" checksum="EA83001B1715508C" modified="2022-01-19" version="1">MWHHMETQTVQRELETLPTTKMAQTNPMPGSMGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVECGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKITIFEKENFIGRQWEICDDYPSLQAMGWFNNEVGSMKIQCGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LKC7</accession>
    <name>A0A8C2LKC7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">28S rRNA (cytosine-C(5))-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NOL1/NOP2/Sun domain family member 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Nsun5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027271981.1">
        <property type="nucleotide sequence ID" value="XM_027416180.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LKC7"/>
    <dbReference type="SMR" id="A0A8C2LKC7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007367.1">
        <property type="protein sequence ID" value="ENSCGRP00001004858.1"/>
        <property type="gene ID" value="ENSCGRG00001006270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761733"/>
    <dbReference type="KEGG" id="cge:100761733"/>
    <dbReference type="CTD" id="55695"/>
    <dbReference type="GeneTree" id="ENSGT00940000155974"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022038">
        <property type="term" value="P:corpus callosum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031641">
        <property type="term" value="P:regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000004">
        <property type="entry name" value="probable 28S rRNA (Cytosine-C(5))-methyltransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000139">
        <property type="entry name" value="probable 28S rRNA (Cytosine-C(5))-methyltransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="14">
        <location>
            <begin position="126"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="234"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027271981.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="50646" checksum="167D639FF2526945" modified="2022-01-19" version="1">MGLYAAAAAVLAGAEGRQGSLKGLVYSSSFQNVKQLYALVCETQRYSAVLDAVIANAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLEERSRPGQAYQVPRFVRVNTLKTCPEDAIDYFKRQGFSYQGRASSLEDLRTLKGQHFLLDPLLSELLVFPAQTDLHDHPLYRAGHLILQDKASCLPAMLLSPPPGSHVIDACAAPGNKTSYIAALLKNQGKIFAFDQDAKRLAAMATLLARAGVSCCELAEKDFLTVSPSDQRYSQVQYILLDPSCSGSGMLSRQLEEHGGGTPSKERLQALAGFQQRALCHALTFPSLQRLVYSTCSLCQEENEDVVQVALQQNSGVFRLAPVLPTWPHRGLSTFPGSEHCLRASPETTLTGGFFIAVFERAEVVPGPAPQDKAVAPEPLSKAPKRKRRRKAAAGASVEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LRD7</accession>
    <name>A0A8C2LRD7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 20">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="4 20">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Mcm3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 20"/>
    <dbReference type="RefSeq" id="XP_027248582.1">
        <property type="nucleotide sequence ID" value="XM_027392781.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LRD7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011345.1">
        <property type="protein sequence ID" value="ENSCGRP00001007319.1"/>
        <property type="gene ID" value="ENSCGRG00001009748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774903"/>
    <dbReference type="KEGG" id="cge:100774903"/>
    <dbReference type="CTD" id="4172"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000006">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000234">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF106">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="22">
        <location>
            <begin position="295"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="662"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027248582.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="90876" checksum="28C38630D334BF7E" modified="2022-01-19" version="1">MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLIVSVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDLQPAFSADDIAKIKKFSKTRSKDVFDQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFAQDDQQDTRIYEKHDSLLHGSKKKKEKMVSAAFMKKYIHVAKIIKPVLIPESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVELQDAEEAVELVQYAYFKKVLEKEKKRKKPSEDESDLEDEEEKSQEDPEQKRKRRKTDATDGESFDPYNFSEAEKETPQVHTPKTDEDDSQETRESQKVELSESRLKAFKAALLDVFQEAHAQSVSMRHLTESINRDKEEPFSEEEIQASLSRMQDDNQVMVSEGIIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LSA4</accession>
    <name>A0A8C2LSA4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 14A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15 16" type="primary">Tmem14a</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16">17A/GY</strain>
            <tissue evidence="15 16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003513560.1">
        <property type="nucleotide sequence ID" value="XM_003513512.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651980.1">
        <property type="nucleotide sequence ID" value="XM_007653790.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248593.1">
        <property type="nucleotide sequence ID" value="XM_027392792.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248594.1">
        <property type="nucleotide sequence ID" value="XM_027392793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LSA4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011528.1">
        <property type="protein sequence ID" value="ENSCGRP00001007485.1"/>
        <property type="gene ID" value="ENSCGRG00001009902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752872"/>
    <dbReference type="KEGG" id="cge:100752872"/>
    <dbReference type="CTD" id="28978"/>
    <dbReference type="GeneTree" id="ENSGT00940000158206"/>
    <dbReference type="OMA" id="MGTRYKK"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="9 10">17A/GY</strain>
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        </source>
    </reference>
    <reference evidence="6" key="4">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_003501160.4"/>
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        <property type="nucleotide sequence ID" value="XM_027435690.2"/>
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        <location>
            <begin position="2125"/>
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        </location>
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        <location>
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    </feature>
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        <location>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1613"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2086"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1279"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2056"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2069"/>
            <end position="2079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027277149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027277150.1"/>
        </source>
    </evidence>
    <sequence length="2425" mass="278681" checksum="18FA7CA9F9D2417E" modified="2022-01-19" version="1">METGSPGLNMKPKSLQLVLEEQVLALQHQMAENQAASWQKLKNSQEAQKRQATLVRKLQAKVLQYRSWCQELEKRLEATGGLIPQRWEGVEEPNLEQLLVRLEEEQQRCESLVEVNTELRLHMEKADVVNKALREDVEKLTVDWSRARDELIRKESQWRLEQEFFKGYLKGEHDRLLNLWREVVTFRRHFLKMKSATDRDLTELKAEHAKLSGSLLTCCLRLTVRAQSRESSGSGRTENEPAQLLLLVAKTQALEKEAHEKSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRETMETLETNHAELMEHEVSLSRNAQEEMLSLQHVIKDIAQVLASVEEEDTVTHSSDHESSLQLDCSGFSPFDPQNPDKALTLVRSVLTRRQQAVQDLRQQLSGCQEAMSFLQQQHRQWEEEGEALRERLHKLTGERDALAGQTVDLQGEVDSLSKERELLQKARGELQEQLEVLEQEAWRLRRVNMELQLQGDSAQGEKQEQQEELHMAVRERELLQEMLVSLEAKQSESLSELMTLREALESSRLEGELLRQEQVEVTAAWARAEQSIAELSASENSLKAEVADLRAAAVKLGALNEALALDKVGLNQQLLQLEQENQSVCSRAEAAEHLRSALQVDLAEAERHREALWEKNTQLQTQLQKAEESGAELQAELKSIREEKEELKEKLSEAHHQQEAATAQLEQLHQDTERQQETLARAVQEKETLVRERATLEVRLQAVERDRQDLTEQVLGLRSAKEQLESNLFETQQQNSVIEVTKGQLEIQVQTITQAKEVIQGEVKCLKLELDAERSRAEQERDAVARQLAQAEQEGQAALEQQKVAHEEELNRLQEKWEKERSLLQQELEKALETLERERTELEVRLREQQTETEALRAQREEERTHADSTLYQMQLETEKERVSLLETLLQTQKELADATQQLERLRKDMKIQKLQEQETTDMLQTQLQGAQQELKEATQQHSEEHAAFRKDREDLQKQVEDLKSQLVTQDDSHRLVKQEIQEKMKEVQEYSRIQKELEKEKASLALSLVEKEGRLLILQEADSVRQQELNSLRQDIQEAQEGQRELSVQVELLRQEVKEKEADFVAREAQLLEELEASRITEQQLRASLWTQEAKTTQLQLQLRSTESQLEVLAAEQQPENQAQAQLASLYSVLQQALGSACESRPELRGGGDSAPSLWGPEPDQNGARRPFKRGSLLTALSAEAVALALQKLHQDLWKAQQARDDLRDQIQKLKQHLTDTEAQKSQVHSDLQDLQRQLSQSQEEKSKWEGKQNSLESELRDLHETVASLQSRLRQAELQKMEAQNEQELLQASKEKLTAQVERLQAFVAEAHAQASAASVLEEDLRTARSALKLKNEEVESERERAQALQEQSELKVAQGKALQENLALLAQTLSNREREVETLQTEIQELEKQREMQKAALELLSLDLKQRSQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQQLSVQQDQIRELEKDRETQRSVLEHQLLELEKKAQVIESQRGQIQDLKKQLVTLECLALELEESHHKVEGQQQVIAELESQREMQRVALTHLTLDLEERSQDLQAQSSQLHELESHGTHLARELQERDQEVKAQRQQIEELQKQKEQLTQDLERKGQELMLQKERIQVLEDQRTLQTKILEEDLEQIKHSLRERGQEMASQRQLMLERADNGQSPGKAQRGSLEHLKLILREKEKEVECQHERIQELEEHVGQVEQQLQGLHRKMGETSLLLTHREQEVATLQRHLQEAKDQGELKEQALQGQLEEAQRALAQRDQELEALQQEQQQTLAQEESMKQKTGALQAALEQAQVTLKERQGELEEHRERAQRLQEELVLEGRQVRALEEVLADLRSEIREHEKAVLALQQQCAEQAQEHEAEARTLQDSWLRAQATLSEQEQELAALRAENQYSRHQEEAAWGQAEALQEALSKAQAALQDKEQSLLEQAELSCTLEASTTALQASLDNCQSRARQLEEALKIREGEIQAQGLQHQEVTQQLQQALSQKEEKLRQQEEQRQLLEKALTQSSQENGIQEKQSLEQERKEDTGGLVASLRELQRTLAQKEEEILMLREAQQRQSLEASSPSHRAFPAEKPAPQLCQELERLQNALRQTEAREIEWREKAQDLARSLAQSKASNNSLQEIAMLLQASVLERESEQQRLQEELVLSRQALEEQQSHGSHSTSRADRGPKAGQDVHPGKVVVAEPSPGVEEKEQWTQRLERLQQAVAQLEFDRSKLQHHNAQLRITLELVERERRKLKRDSMRASRAGSLEMKEAMASSPAQQDGRAAQRGSSDSMRVVELQREVALLRAQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLTVAQAPEATVLEAETRKLDESLSQSLASPEPVLLHPSLDTAQTTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M3K6</accession>
    <name>A0A8C2M3K6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Odontogenesis associated phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Odaph</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_016835743.1">
        <property type="nucleotide sequence ID" value="XM_016980254.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244159.1">
        <property type="nucleotide sequence ID" value="XM_027388358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M3K6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016281.1">
        <property type="protein sequence ID" value="ENSCGRP00001012048.1"/>
        <property type="gene ID" value="ENSCGRG00001013555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755317"/>
    <dbReference type="KEGG" id="cge:100755317"/>
    <dbReference type="CTD" id="152816"/>
    <dbReference type="GeneTree" id="ENSGT00390000005348"/>
    <dbReference type="OrthoDB" id="9450558at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070175">
        <property type="term" value="P:positive regulation of enamel mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031706">
        <property type="entry name" value="ODAPH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40376">
        <property type="entry name" value="ODONTOGENESIS ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40376:SF1">
        <property type="entry name" value="ODONTOGENESIS ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15848">
        <property type="entry name" value="ODAPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678719" evidence="1">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027244159.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14903" checksum="C1A93A92768233E9" modified="2022-01-19" version="1">MAPGFLFWVLVGWSVLTMAEGQDVVTPPGGSQDNVTPTDCQIFTLTPPPPTRKPAVTRAQPNTRIFPWTWFHFLPRRPGFYWPPNRPLLLPNYNPGFQFHPFYLPQGRLSGRYFLRGQLQGGSSSEESIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M7R2</accession>
    <name>A0A8C2M7R2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Atp6v0a2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269696.1">
        <property type="nucleotide sequence ID" value="XM_027413895.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M7R2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017974.1">
        <property type="protein sequence ID" value="ENSCGRP00001013737.1"/>
        <property type="gene ID" value="ENSCGRG00001014794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766909"/>
    <dbReference type="KEGG" id="cge:100766909"/>
    <dbReference type="CTD" id="23545"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036295">
        <property type="term" value="P:cellular response to increased oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF22">
        <property type="entry name" value="V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027269696.1"/>
        </source>
    </evidence>
    <sequence length="855" mass="97973" checksum="BF35C9D4D28D1779" modified="2022-01-19" version="1">MGSLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERILVYLVQEITRADIPLPEGEASPPAPPLKHVLEMQEQLQKLEVELREVTKNKEKLRKNLLELVEYTHMLRITKTFLKRNVEFEPTYEEFPALENDSLLDYSCMQRLGAKLGFVSGLIQQGKVEAFERMLWRACKGYTIVTYAELDESLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHIYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVVQVRKMKAIYHMLNMCSFDVTNKCLIAEVWCPEVDLPGLRRALEEGSRESGATIPSFMNTIPTKETPPTLIRTNKFTEGFQNIVDAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPKLSQSQEILRMFFNGRYILLLMGLFSVYTGLIYNDCFSKSVNIFGSGWNVSAMYSSSHSEEEHKMVLWNDSTIRHSRTLQLDPNIPGVFRGPYPFGIDPIWNLATNRLTFLNSFKMKMSVILGIIHMTFGVTLGIFNHLHFRKKFNIYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSREAPSILIEFINMFLFPSSETHGLYPGQAHVQRVLLALTVLSVPVLFLGKPLFLLWLHNGRSCFGMSRSGYTLVRKDSEEEVSLLGSQDIEEGSNRMEEGCREVTCEEFNFGEILMTQTIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFAVLTIFILLVMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFSNDDNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MAY1</accession>
    <name>A0A8C2MAY1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Ap2s1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with CCDC32; the interaction is direct and mediates association of CCDC32 with adaptor protein complex 2 (AP-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027287148.1">
        <property type="nucleotide sequence ID" value="XM_027431347.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317139.1">
        <property type="nucleotide sequence ID" value="XM_035461248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MAY1"/>
    <dbReference type="SMR" id="A0A8C2MAY1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019525.1">
        <property type="protein sequence ID" value="ENSCGRP00001015285.1"/>
        <property type="gene ID" value="ENSCGRG00001015937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764194"/>
    <dbReference type="KEGG" id="cge:100764194"/>
    <dbReference type="CTD" id="1175"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000004">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="12">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027287148.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="17018" checksum="CA3FD868C65AEDF6" modified="2022-01-19" version="1">MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MBA4</accession>
    <name>A0A8C2MBA4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional adapter 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ADA3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptional adapter 3-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16 17" type="primary">Tada3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16 17">17A/GY</strain>
            <tissue evidence="16 17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007651923.1">
        <property type="nucleotide sequence ID" value="XM_007653733.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651927.1">
        <property type="nucleotide sequence ID" value="XM_007653737.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284881.1">
        <property type="nucleotide sequence ID" value="XM_027429080.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035293634.1">
        <property type="nucleotide sequence ID" value="XM_035437743.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035448808.1"/>
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    <dbReference type="Ensembl" id="ENSCGRT00001020753.1">
        <property type="protein sequence ID" value="ENSCGRP00001016509.1"/>
        <property type="gene ID" value="ENSCGRG00001016793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755727"/>
    <dbReference type="KEGG" id="cge:100755727"/>
    <dbReference type="CTD" id="10474"/>
    <dbReference type="GeneTree" id="ENSGT00390000008947"/>
    <dbReference type="OMA" id="TPNKFWA"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018537"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033410"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027284881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035304699.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48888" checksum="686EB80C93560C0A" modified="2022-01-19" version="1">MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNVQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MDU6</accession>
    <name>A0A8C2MDU6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein FCF1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Fcf1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511577.1">
        <property type="nucleotide sequence ID" value="XM_003511529.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274330.1">
        <property type="nucleotide sequence ID" value="XM_027418529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MDU6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022112.1">
        <property type="protein sequence ID" value="ENSCGRP00001017868.1"/>
        <property type="gene ID" value="ENSCGRG00001017796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771331"/>
    <dbReference type="KEGG" id="cge:100771331"/>
    <dbReference type="CTD" id="51077"/>
    <dbReference type="GeneTree" id="ENSGT00940000153117"/>
    <dbReference type="OMA" id="GMMDCLL"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="10">
        <location>
            <begin position="67"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027274330.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23357" checksum="FBFA5000CCD87DD9" modified="2022-01-19" version="1">MGKQKKTRKYATMKRMLSLRDERLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFDRLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJC0</accession>
    <name>A0A8C2MJC0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Phactr1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035298825.1">
        <property type="nucleotide sequence ID" value="XM_035442934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MJC0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023818.1">
        <property type="protein sequence ID" value="ENSCGRP00001019574.1"/>
        <property type="gene ID" value="ENSCGRG00001018954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768215"/>
    <dbReference type="KEGG" id="cge:100768215"/>
    <dbReference type="CTD" id="221692"/>
    <dbReference type="GeneTree" id="ENSGT00940000155842"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140059">
        <property type="term" value="P:dendrite arborization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001222">
        <property type="term" value="P:regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043149">
        <property type="term" value="P:stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF6">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU301113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035298825.1"/>
        </source>
    </evidence>
    <sequence length="645" mass="73174" checksum="7E54F22E5C37BB64" modified="2022-01-19" version="1">MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSFEVLQASDIMDGPVSQESPSASESGVLLSQDPSAKPVLFLPPKKPAAFSGDHEETPVKQLSLLKQPPALPPKPTARIANHLTDPGAPVKLPCLPVKLSPPLPPKKVLICMPVGGPELSLASYAAQKSSQQHHHTVLPPQMQHQLQYGSHGQHLPPSTGTLPMHPSSCRVIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSSDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDYEDSSCLYAREEEEEEDDEEDDTSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJS6</accession>
    <name>A0A8C2MJS6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDKN2A interacting protein N-terminal like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">CDKN2AIP N-terminal-like protein isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Cdkn2aipnl</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CARF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283385.1">
        <property type="nucleotide sequence ID" value="XM_027427584.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MJS6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024462.1">
        <property type="protein sequence ID" value="ENSCGRP00001020218.1"/>
        <property type="gene ID" value="ENSCGRG00001019440.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103159798"/>
    <dbReference type="KEGG" id="cge:103159798"/>
    <dbReference type="CTD" id="91368"/>
    <dbReference type="OrthoDB" id="2359216at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021859">
        <property type="entry name" value="XTBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11952">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51827">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRN2-binding (XTBD)" evidence="2">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027283385.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13252" checksum="4532F32C69C14C88" modified="2022-01-19" version="1">MVGGEASVSVEELVSGVRQAADFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MKP7</accession>
    <name>A0A8C2MKP7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tenascin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Hexabrachion</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tenascin-C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Tnc</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tenascin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295735.1">
        <property type="nucleotide sequence ID" value="XM_035439844.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314252.1">
        <property type="nucleotide sequence ID" value="XM_035458361.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001023582.1">
        <property type="protein sequence ID" value="ENSCGRP00001019338.1"/>
        <property type="gene ID" value="ENSCGRG00001018791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754133"/>
    <dbReference type="KEGG" id="cge:100754133"/>
    <dbReference type="CTD" id="3371"/>
    <dbReference type="GeneTree" id="ENSGT00940000155188"/>
    <dbReference type="OMA" id="HHNGRCE"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQU4</accession>
    <name>A0A8C2MQU4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vacuolar protein sorting-associated protein 33A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Vps33a</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Lysosome membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269786.1">
        <property type="nucleotide sequence ID" value="XM_027413985.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MQU4"/>
    <dbReference type="SMR" id="A0A8C2MQU4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026693.1">
        <property type="protein sequence ID" value="ENSCGRP00001022448.1"/>
        <property type="gene ID" value="ENSCGRG00001020988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769368"/>
    <dbReference type="KEGG" id="cge:100769368"/>
    <dbReference type="CTD" id="65082"/>
    <dbReference type="GeneTree" id="ENSGT00940000155165"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032400">
        <property type="term" value="P:melanosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030220">
        <property type="term" value="P:platelet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048070">
        <property type="term" value="P:regulation of developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035751">
        <property type="term" value="P:regulation of lysosomal lumen pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.850:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1910:FF:000005">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1910:FF:000008">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000004">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027269786.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67510" checksum="64B303F7E1A2459A" modified="2022-01-19" version="1">MAAHLSYGRVNLNVLREALRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTLKGNRLPAADVKNIIFLVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMESEGAFKECYLDGDQTSLYHAAKGLMTLQALYGTIPHIFGKGECARQVANMMVRMKREFTGSQNSVFPVFDNLLLLDRNVDLLTPLATQLTYEGLIDEIYGIQNSYVKLPPEKFAPKKQGGSGGKDLPTEAKKLQLNSAEELYAEIRDKNFNAVGSVLSKKAKIISAAFEERHNAKTVGEIKQFVSQLPHMQAARGSLANHTSIAELIKDVTTSEDFFDKLTVEQEFMSGIDTDKVNNYIEDCIAQKHPLIKVLRLVCLQSVCNSGLKQKVLDYYKREILQTYGYEHILTLNNLEKAGLLKAQTGGRNNYPTIRKTLRLWMDDVNEQNPTDISYVYSGYAPLSVRLAQLLSRPGWRSIEEVLRILPGPHFEERQSLPTGLQKKRQPGENRVTLIFFLGGVTFAEIAALRFLSQLEDGGTEYVIATTKLMNGSSWVEALMEKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MRD3</accession>
    <name>A0A8C2MRD3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Proprotein convertase subtilisin/kexin type 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Paired basic amino acid cleaving enzyme 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Subtilisin-like proprotein convertase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Subtilisin/kexin-like protease PACE4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Pcsk6</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 18 19">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263897.1">
        <property type="nucleotide sequence ID" value="XM_027408096.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MRD3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023603.1">
        <property type="protein sequence ID" value="ENSCGRP00001019359.1"/>
        <property type="gene ID" value="ENSCGRG00001018811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771371"/>
    <dbReference type="KEGG" id="cge:100771371"/>
    <dbReference type="CTD" id="5046"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048406">
        <property type="term" value="F:nerve growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032902">
        <property type="term" value="P:nerve growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032940">
        <property type="term" value="P:secretion by cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007354">
        <property type="term" value="P:zygotic determination of anterior/posterior axis, embryo"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.850:FF:000001">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000002">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000015">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000019">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000021">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF8">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 18 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 18 19" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18 19" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="22">
        <location>
            <begin position="485"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="21">
        <location>
            <begin position="921"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="645"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="17 18">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="17 18">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="17 18">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027263897.1"/>
        </source>
    </evidence>
    <sequence length="959" mass="106130" checksum="3EDCCE3BC0BB8FC2" modified="2022-01-19" version="1">MPPRAPPAPGPRPPPRATDVARGAGDAGRHGLPPLALRPWRWLFLLALPAACSAPPPPRPVYTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWYMHCADKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHMCVATADKRPRSIPIVQVLRTTALTNACADHSDQRVVYLEHVVARISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHCWGEKAEGEWTLEIQDIPSQVRNPEKQGKLKEWSLILYGTAEHPYRTFSSHQSRSRMLELSVPELEPPKAVGPPPQAETPEDEEEYTAPSTQGSPNTLQTSACHPECGDKGCDGPNADQCLNCVHFSLGNAKISRKCVSECPLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHYQETNTCVTLCPAGLYADESERHCLKCHPSCQKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIKCGECHHTCRTCVGPSREECIHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCEGSSRNCSRCKAGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MWC2</accession>
    <name>A0A8C2MWC2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein SGT1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Suppressor of G2 allele of SKP1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Sugt1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SGT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007650031.1">
        <property type="nucleotide sequence ID" value="XM_007651841.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249839.1">
        <property type="nucleotide sequence ID" value="XM_027394038.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MWC2"/>
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    <sequence length="336" mass="38214" checksum="68FFDC0657E47B3A" modified="2022-01-19" version="1">MAAPAAGSATSQRFSQSFSDALIDEDPQAALEELTKALEHNPKDAQYYCQRAYCHMLLGKHLDGIADVKKSLELNPNNPTAILRKGMCEYHQKDYASALDTFIAGQKLDSADANFAIWIKRCQETQPASESEVSASQRTQSKIKYDWYQTESQVIITLMIKNIQKNDVNMEFSEKELSALVKLPSGEDYHMKLRLLHPIVPEQSTFKVLSTKIEIKMKKPEAVRWEKLEGQGDEPTPKQFTSDVKNLYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
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            <taxon>Muroidea</taxon>
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            <taxon>Cricetulus</taxon>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
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    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
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    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_027392825.2"/>
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        <property type="nucleotide sequence ID" value="XM_035457535.1"/>
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        <property type="entry name" value="ZF_PHD_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="753"/>
        </location>
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            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1341"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1511"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1560"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1577"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1614"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1643"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1695"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1736"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1759"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1864"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1888"/>
            <end position="2005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027248626.1"/>
        </source>
    </evidence>
    <sequence length="2005" mass="224418" checksum="F7B5C45B9EF240B7" modified="2022-01-19" version="1">MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSTSQNVLEDSLKNMLSDKDPMLGSASNQFCLPVLDSNDPNFQMPCSTVVGLDDIMDEGVVKESGNDTIDEEELILPNRSLRDRVEDNSVRSPRKSPRLMAQEQVRSLRQSTIAKRSNAAPLSTKKPPGKTVSSPKVGVKPSERCQSKEDLYTALKSEYPKENRRSSRHAEPIDVVPEVSASSVDSSVSPCVEMKDEAELDSKHACNNNQGELNVPSHELNCPLLSESCASVEEKKNETLMECKSKTDCSPLFKFSDKEEEQNDVVSGEMDDTIEERSAVGKLEQEAEEIKLPCEGDQMTEEPGPSDVFSDSACTDKNRTEKNEAAECHLELKSTVALGDKAENSLQRNQMETSLGYCEDMASNDVQLQSTEFHKSNLEDVDTCAFEPESTTLENTICDVPDQNSKQLNITQSIKVDSHETADLQDDRSSLEPKSIKSKHIKSNAKQSMTTETPRKTVAVKHEVVHSKTKSNVKSVKRNADEPEPQHDLQRPVKVRKGQLEKDLKNQSCNSGVKSVKSQAHSVLKKTSQDQNVMQVSKPLTHSLSDKLHGHSGSSKEPHPVAQSGHSLHSSQKLSHKPQQQAPVVKATSHGKDEHEHPGSEHLKEEDKLKLKKPEKNLQPRQRRSSRSFSLDEPPLFIPDNIATVKREGSDHTSSVESKYMWTPSKQCGFCKKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCVRCCAEEDKKTDISDTDILEDQTTVEAHSEEKTMECEKLGSSKHMVANDKNKYMDDAVKHKVKILKRESGEGKTSSDSRDNDIKKWQLAPLRKLGQPALPRRSSEEKGEKTHKESTANTCTVEKASKSGTHEKQEMKKKKIEKGGPHVHPPAAASKPSADQIRQSVRHSLKDILMRRLTDSNLKVPEEKAAKVATKIEKELFSFFRDTDSKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTPDHLIRMSPEELASKELAAWRRRENRHTIEMIEKEQREVERRPITKITHKGEIEIESDAPMKEQEATMEMQEPSANKSLEKTEGSEKQKEEVDSTSKDTTSQHRQHLFDLNCKICIGRMAPPVDDLSPKNVKVVVGGARKHSDNEAESIADALSSTTNILASEFFEEEKQESPKSTFSPAPRPEMPGTVEVESTFLARLNFIWKGFINMPSVAKFVTKAYPVSGSPEYLTEDLPDSIQVGGRISPQTVWDYVEKIKASGTKEICVVRFTPVTEEDQISYTLLFAYFSSRKRYGVAANNMKQVKDMYLIPLGAADKIPHPLVPFDGPGLELHRPNLLLGLIIRQKLKRPHSASAGPSHTTETPETAPVALPPDKKGKMESSMEETAEEENDFFNSFTTVLHKQRNKPLQSLQEDLPTTAEPLMEVSRQEPPKPLRFLPGVLIGWENQPSTLELANKPLPVDDILQSLLGTTGQVFEQAQPVGEQSTLKEIPFISDQTSPKLEKIDKVEVTEGEAKEIKVKVDNSSESTGKNSGVEETSLVGSSSISPGPLTSLSLRGKPPDVSTEAFLTNLSKQEETVENKERTLKRQLLQEQESTLQDNRTSNNSPCRPSTGKGNIDGSAGCSESLIANTRSPQFINLKRDPRQAAGRSQQTTSESKEAESCRNGDKNALPGPSHSKEPLAEPVSGEGKLSSVEKNSCVEQNDDSEAAQNPSSVENLNSSQTEQANPLQEDILTQNIETVNPFRRGSATASSHFEAGSTCQSEFPSKSINFTSRSTSPRASASFSSMRPQQPSVQHLKSSPPGFPFPAPPNFPPQSVFGFPPHLPPPLLPPPGFGFPQNPMVPWPPVHLPGQPQRMMGPLSQASRYMGPQNFYQVKDIRRPERRHSDPWGRQDQQQLDRPFNRGKGDRQRFYSDSHHLKRERHDKEWEQESERHRHRDRSQDRDRKSKEEGHKERARVSHSDGTTDGKAGRESKNADKKPDHEKEKEREKNKHREGDKDRERYRKDRDHTDRAKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MYU6</accession>
    <name>A0A8C2MYU6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Fkbp3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="RefSeq" id="XP_003512321.2">
        <property type="nucleotide sequence ID" value="XM_003512273.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272306.1">
        <property type="nucleotide sequence ID" value="XM_027416505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MYU6"/>
    <dbReference type="SMR" id="A0A8C2MYU6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026688.1">
        <property type="protein sequence ID" value="ENSCGRP00001022443.1"/>
        <property type="gene ID" value="ENSCGRG00001020987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757543"/>
    <dbReference type="KEGG" id="cge:100757543"/>
    <dbReference type="CTD" id="2287"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21063">
        <property type="entry name" value="BTHB_FKBP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.80:FF:000002">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000023">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043368">
        <property type="entry name" value="FKBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041200">
        <property type="entry name" value="FKBP3_BTHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46493">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46493:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18410">
        <property type="entry name" value="BTHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 10 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027272306.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25204" checksum="1BE304340B96347E" modified="2022-01-19" version="1">MAAAVPQRAWTVEQLRSEQLPKKDIIKFLQDHGSDSFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFETKRFKGTETVSKVSEQVKNVKLNDDKPKETKSEETLDEGPPKYTKSILKKGDKTNFPKKGDIVHCWYTGTLPDGTVFDTNIQTSSKKKKNAKPLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNTKLIFEVELVDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N3V5</accession>
    <name>A0A8C2N3V5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AFG2 interacting ribosome maturation factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein C1orf109 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Airim</name>
        <name evidence="4 5 6 7" type="synonym">CUNH1orf109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4 5 6">17A/GY</strain>
            <tissue evidence="4 5 6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="1" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007641050.1">
        <property type="nucleotide sequence ID" value="XM_007642860.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641051.1">
        <property type="nucleotide sequence ID" value="XM_007642861.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641052.1">
        <property type="nucleotide sequence ID" value="XM_007642862.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016830988.1">
        <property type="nucleotide sequence ID" value="XM_016975499.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255033.1">
        <property type="nucleotide sequence ID" value="XM_027399232.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255034.1">
        <property type="nucleotide sequence ID" value="XM_027399233.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255035.1">
        <property type="nucleotide sequence ID" value="XM_027399234.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255036.1">
        <property type="nucleotide sequence ID" value="XM_027399235.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N3V5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032340.1">
        <property type="protein sequence ID" value="ENSCGRP00001028092.1"/>
        <property type="gene ID" value="ENSCGRG00001024913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753330"/>
    <dbReference type="KEGG" id="cge:100753330"/>
    <dbReference type="CTD" id="54955"/>
    <dbReference type="OMA" id="SHVEQVF"/>
    <dbReference type="OrthoDB" id="6605214at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029159">
        <property type="entry name" value="CA109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16234:SF5">
        <property type="entry name" value="AFG2-INTERACTING RIBOSOME MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16234">
        <property type="entry name" value="SIMILAR TO HYPOTHETICAL PROTEIN FLJ20508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15011">
        <property type="entry name" value="CA109-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001028092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027255033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027255034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027255035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027255036.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24613" checksum="85F62C1250245481" modified="2022-01-19" version="1">MAQDQPLLAVQEVLRKCFPVVQEQQDLWQSTLQGCSSLLSSLSNLAEQLQASQNLRFEDVPALRPFPDLQERLRRKQLEAGDIVLDKLAERLATLLKVRDTISSHVERVFQTYEQHSAALDMDAVLQPSVVSPSVADMLEWLQDIDRHYRSSYLKRKYLLSSIHWGDLASIQALPKAWNQISEDECQTLVPDILVSVSFFLEEPGCCTVSGDQESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QIT6</accession>
    <name>A0A8C2QIT6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ethanolamine kinase</fullName>
            <ecNumber evidence="12">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Etnk1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="12"/>
    <dbReference type="RefSeq" id="XP_027285957.1">
        <property type="nucleotide sequence ID" value="XM_027430156.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QIT6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019061.1">
        <property type="protein sequence ID" value="ENSCGRP00001014823.1"/>
        <property type="gene ID" value="ENSCGRG00001015598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765795"/>
    <dbReference type="CTD" id="55500"/>
    <dbReference type="GeneTree" id="ENSGT00950000182939"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000002">
        <property type="entry name" value="Ethanolamine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF91">
        <property type="entry name" value="ETHANOLAMINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027285957.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41999" checksum="EC1E2136D80B6ACF" modified="2022-01-19" version="1">MANYIHVPPGSPEVPKLDVTVQDQEEQRCRDGALSLLRHLRPHWDPREVTLQLFTDGITNKLIACYVGDTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPQHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDVPSPQLLQEEMTWMKEILSSLGSPVVLCHNDLLCKNIIYNEKQGEVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPDRELQGQWLRSYLEAYKEYKGFGSEVTEKEVETLFIQVNQFALASHFFWGLWALIQAKYSTIEFDFLGYAIVRFNQYFKMKPEVTALKMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QKT0</accession>
    <name>A0A8C2QKT0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Kv channel-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">LOC100755926</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027242776.2">
        <property type="nucleotide sequence ID" value="XM_027386975.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QKT0"/>
    <dbReference type="SMR" id="A0A8C2QKT0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023804.1">
        <property type="protein sequence ID" value="ENSCGRP00001019560.1"/>
        <property type="gene ID" value="ENSCGRG00001018947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755926"/>
    <dbReference type="KEGG" id="cge:100755926"/>
    <dbReference type="GeneTree" id="ENSGT00940000158985"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000043">
        <property type="entry name" value="Kv channel-interacting protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF30">
        <property type="entry name" value="KV CHANNEL-INTERACTING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="8" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027242776.2"/>
        </source>
    </evidence>
    <sequence length="233" mass="26929" checksum="0B17F98AC9211B7E" modified="2022-01-19" version="1">MLTLEWESEGLQTVGIVVIICASLKLLHLLGLIDFSEDSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QLE2</accession>
    <name>A0A8C2QLE2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 25 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Digestive organ expansion factor homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UTP25 small subunit processor component</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Utp25</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing. Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver. Also involved in the sympathetic neuronal development. Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with CAPN3; the interaction is required for CAPN3 translocation to the nucleolus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272352.1">
        <property type="nucleotide sequence ID" value="XM_027416551.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QLE2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025103.1">
        <property type="protein sequence ID" value="ENSCGRP00001020859.1"/>
        <property type="gene ID" value="ENSCGRG00001019879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765405"/>
    <dbReference type="CTD" id="27042"/>
    <dbReference type="GeneTree" id="ENSGT00390000000709"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000962">
        <property type="entry name" value="digestive organ expansion factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="287"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="565"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027272352.1"/>
        </source>
    </evidence>
    <sequence length="754" mass="86967" checksum="FABDD1045F0E57AF" modified="2022-01-19" version="1">MGKRRNRGRSQLLSTMTKKQKKHLRDFGEEHPFYDRVSKKEATPQICQLSESSDSSHSESDSESEQEHISGYHRLLSTLKNVSEEEDEEEEEEEDDSAVGDEEMNDEDGDEDVIVEEETVETAETQECMSLADVSKEKDGEEPADASQKSSEEFTDAKHESLFSLETNFLEEDSGGSSSSQRTSQDPFQQHVNKELKEKEVQAATSSPPTTQQLKWPVLGQLVFSSKFQKMETFKPPKDVDMKSLHLQKPLESTWKKTNSQFLSGPQQSNSPFTPLQKELFLIMNSYRDLFYPERTALKNGEEVRHVYCLHAINHVLKANAQVLANNSRRRSQKLGVGEDDDFRDQGLTRPKVLIVVPFREAALRVVQLFISLLEGDSKKKVIVSNKKRFQGEYGSNPEERPPNLKRPEDYEAVFVGNIDDHFRIGVAILQRSIRLYAPFYSSDILIASPLGLRTIIGGEGEKKRDFDFLSSIELLIIDQADIYLMQNWEHVLHLVNHMNLLPLESHGVDFSRVRMWSLNNWSRYYRQTLLFGALQDAQINSVFNKHCVNAQGQVAVRNVPMTGSISHVLVQLPHVFQRMEAQDVTSVIDARFHFFINKILPQYRDAVMSHTLIYVPSYFDFVRLRNYFKKEELNFTHICEYTQKSGVSRARHFFLKGEKQFLLLTERFHFYKRYTIKGIRNLIFYELPTYPHFYSEVCNMLSAARRGEEATWTCTVLYSKYDAQRLASVVGVERAAQMLQSPKNVHLFITGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QLE7</accession>
    <name>A0A8C2QLE7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase Mer</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Proto-oncogene c-Mer</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Receptor tyrosine kinase MerTK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31 34" type="primary">Mertk</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="33" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
            <tissue evidence="34">Liver</tissue>
        </source>
    </reference>
    <reference evidence="31" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner. Interacts with TIMD4; this interaction enhances TIMD4-mediated efferocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035299011.1">
        <property type="nucleotide sequence ID" value="XM_035443120.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302219.1">
        <property type="nucleotide sequence ID" value="XM_035446328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QLE7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024551.1">
        <property type="protein sequence ID" value="ENSCGRP00001020307.1"/>
        <property type="gene ID" value="ENSCGRG00001019494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755929"/>
    <dbReference type="CTD" id="10461"/>
    <dbReference type="GeneTree" id="ENSGT00940000155669"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001779">
        <property type="term" value="P:natural killer cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001818">
        <property type="term" value="P:negative regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000107">
        <property type="term" value="P:negative regulation of leukocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051250">
        <property type="term" value="P:negative regulation of lymphocyte activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097350">
        <property type="term" value="P:neutrophil clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050766">
        <property type="term" value="P:positive regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032940">
        <property type="term" value="P:secretion by cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060068">
        <property type="term" value="P:vagina development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05749">
        <property type="entry name" value="IgI_2_Axl_Tyro3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14204">
        <property type="entry name" value="PTKc_Mer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000902">
        <property type="entry name" value="MER proto-oncogene, tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001050">
        <property type="entry name" value="MER proto-oncogene, tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000834">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase MER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000089">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000296">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000111">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF257">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE MER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 34" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="29">
        <location>
            <begin position="102"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="29">
        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="30">
        <location>
            <begin position="297"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="30">
        <location>
            <begin position="397"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="599"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00070212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="RefSeq" id="XP_035302219.1"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111913" checksum="58A4E98BDF17F904" modified="2022-01-19" version="1">MQARSGGHRRVQDVSGSVHLSGENFQIRGSAMVLASLLLGLLLLPAPWRATAEKAEETKPDDHRPFSPHSSGYQLSPSQTGRSLPIHTAVPQMTSAASKLLPPVAFNHTIGHIILSEHKNVKFNCSINIPNMYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSITSVQRSDNGSYICKMKVNDKEIVSDPIYVEVQGLPYFIRQPESMNVSRNTAFNLTCHAVGPPEPINIFWVQNSSRVNEKPERSPSVLTVPGLTETAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVHILSRTAHSIQLSWVPGFDGYSPFQDCSIQVKEADLLSNGSVMTFNTSASTHLYEIQQLQALANYSIGVSCRNEIGWSAVSPWILASTTEGAPSVAPLNITVFLNESTNSVEIRWMKPPIKRQDGELVGYRISHMWESSETSQRELSEEVGQNGSWAQIPVQIHNATCTVRIAAITKGGVGPFSEPVKISIPEHSRVDYAPSSTPAPGNTESMLIILGCFCGFVLIGLILYISLAIRRRVQETKFGGAFSEEDSQLVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGSLKQDDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTFLLYSRIETRPKYIPLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRLKLEKLSESLPDAQDKESIIYINTQLLESCEGLADGPSLAGLDMNIDPDSIIASCTPSTATSVVTAEVHENNLHEERYILDGVSEEWEDVASTPFAAATSGKDGVLPEDKLTKNGISWSHCSTLPLGSPSADELLFADDSSEDSEVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EVN3</accession>
    <name>A0A9J7EVN3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100754361</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="12"/>
    <dbReference type="RefSeq" id="XP_027244303.1">
        <property type="nucleotide sequence ID" value="XM_027388502.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EVN3"/>
    <dbReference type="GeneID" id="100754361"/>
    <dbReference type="KEGG" id="cge:100754361"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004705">
        <property type="term" value="F:JUN kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07850">
        <property type="entry name" value="STKc_JNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="73"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="414"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027244303.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="53586" checksum="05F5FDD4A068E9D4" modified="2023-06-28" version="1">MAVVKDTVFMSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EXX7</accession>
    <name>A0A9J7EXX7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette sub-family G member 3 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100759972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027244273.1">
        <property type="nucleotide sequence ID" value="XM_027388472.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EXX7"/>
    <dbReference type="GeneID" id="100759972"/>
    <dbReference type="KEGG" id="cge:100759972"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042887">
        <property type="term" value="F:amide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000622">
        <property type="entry name" value="ATP-binding cassette sub-family G member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF70">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="37"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027244273.1"/>
        </source>
    </evidence>
    <sequence length="651" mass="74203" checksum="0B8DD643572A92F3" modified="2023-06-28" version="1">MSSNDDPVAIPMIERKPNDLPGMDTSDLNTFTGEAVLSFHNISYRETVQSGFPFRKKTCVIERLSNINGIMKPGLNAIMGPQDGSRTLLLDVLAARKDPRGLLGDVLINGKPRPANFKCTSGYVPQNDMVMHTMTVRENVEFSAALRLPMSITRDEKRRRINEVLELLHLDEESNVKPRSKELRKRTSIAMELITGHPVLFLEDPTTDLDLSTTTDVFSVLRRMSKRGQTIIFSITQPPYSIFRFFDTLTLVASGKVMFHGPAQKALEYFTSAGYNYDSLNNPVDFFLDIISGGSSAILDTEEDCYEADKYKELPERQHQVTEKLANMFAQSSLYSEMRTELDPLLGEQKVGRSSALEEITCVTPFWHQLWWITCRSFKKFQCFSWVTVIQAIIEVIMAVVIGTIFYFLQDDCTEVQRRTAVLYLLTGFECFTSLSARELFMNDRDHFLHEHTSGYYSVSSYFLGKLLAELVPRRLLQSIILTVIIFIISGIRRDVKGFFTMIFTATMLVYSASSVSLSLGAGENAAAIPTYLIINYIMFMLFTSGLSLYHINFMYDLSWIQYFSIPHYGFSALQHNEFLGQNFCPEHKTAEISRCQGYVICTTEEYLANQGIDISSWGFWKNYVALGCIMIIFLSITYVQLLSLKKKRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZQ1</accession>
    <name>A0A9J7EZQ1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100757574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007625718.1">
        <property type="nucleotide sequence ID" value="XM_007627528.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247437.2">
        <property type="nucleotide sequence ID" value="XM_027391636.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100757574"/>
    <dbReference type="KEGG" id="cge:100757574"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027247437.2"/>
        </source>
    </evidence>
    <sequence length="142" mass="15197" checksum="3AEB0AB7AA5D35CC" modified="2023-06-28" version="1">MGMFGVYNGQKSKFDDTHFWHEPCPQQPTSLCYVASYLLAALGGNSSPTAKDIKKILDSVGIKGDYDQLSKVISRQSXMGKRDDVITQSIGKLVSVPAGGAVAAILGSAAPAASSLPSSREEKQKKEESEESDGDVRFVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F3T2</accession>
    <name>A0A9J7F3T2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Importin-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Importin subunit beta-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Karyopherin beta-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ran-binding protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Ipo5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the importin beta family. Importin beta-3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027249711.1">
        <property type="nucleotide sequence ID" value="XM_027393910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F3T2"/>
    <dbReference type="GeneID" id="100764714"/>
    <dbReference type="KEGG" id="cge:100764714"/>
    <dbReference type="CTD" id="3843"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000074">
        <property type="entry name" value="importin-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="15">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027249711.1"/>
        </source>
    </evidence>
    <sequence length="1069" mass="120574" checksum="496D39EB2E9AF206" modified="2023-06-28" version="1">MQETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKICDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNMGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLRPHLEATLQLSLKLCGDTTLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLSSEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDIIEHCSPSSFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFSYLCDLIESNNPIVLGPNNTNLPKIFGIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F8T9</accession>
    <name>A0A9J7F8T9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="35 36">Serine/threonine-protein kinase mTOR</fullName>
            <ecNumber evidence="36">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="42" type="primary">Mtor</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="41">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="41" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="41">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="42" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="42">17A/GY</strain>
            <tissue evidence="42">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="33 43">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32 43">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:10597"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Lysosome membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Microsome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion outer membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 36">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="36"/>
    <dbReference type="RefSeq" id="XP_027254008.1">
        <property type="nucleotide sequence ID" value="XM_027398207.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100755421"/>
    <dbReference type="KEGG" id="cge:100755421"/>
    <dbReference type="CTD" id="2475"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
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        </source>
    </evidence>
    <sequence length="2549" mass="288724" checksum="D1AC8EF1C947C9CF" modified="2023-06-28" version="1">MLGTGPAVATASSATSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNSTRIGRFANYLRNLLPSSDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGASPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRSSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKTVQVDATVFTCVSMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVASITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLSFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSQGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGFTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGATPAILESLISINNKLQQPEAASGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTAHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAASAAAATSTEGSNSESETESNENSPTPSPVQKKVTEDLSKTLLLYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F9S2</accession>
    <name>A0A9J7F9S2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA 3'-terminal phosphate cyclase</fullName>
            <ecNumber evidence="2">6.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA terminal phosphate cyclase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100760159</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="2"/>
    <dbReference type="RefSeq" id="XP_027241629.1">
        <property type="nucleotide sequence ID" value="XM_027385828.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251385.1">
        <property type="nucleotide sequence ID" value="XM_027395584.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F9S2"/>
    <dbReference type="GeneID" id="100760159"/>
    <dbReference type="KEGG" id="cge:100760159"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00874">
        <property type="entry name" value="RNA_Cyclase_Class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000002">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, RPTC, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="12">
        <location>
            <begin position="184"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027251385.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39434" checksum="2C0EDB5C7F2959F6" modified="2023-06-28" version="1">MEGQRVEVDGGIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMVRDLCDGHLEGAEIGSTEITFIPEKIRGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELRLKGGTNAEMAPQIDYTMMVFKPIVEKFGFKFDCDIKMRGYYPKGGGEVIVRMSPVKQLDPINLTDRGSVTKIYGRAFVAGVLPLKVAKDMAAAAVRCIRKEIRDLYVNIQPLQESRDQAFGNGSGIIIVAETSTGCLFAGSSLGKRGVNADKVGIEAAEVLLANLRHGGTVDEYLQDQLIIFMALANGISRIKTGPVTLHTQTAIHFAEQLAKAKFTVKKSEEEEDASKDAYIIECEGIGMANPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FCQ6</accession>
    <name>A0A9J7FCQ6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear body protein SP140-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100751314</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027253227.1">
        <property type="nucleotide sequence ID" value="XM_027397426.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FCQ6"/>
    <dbReference type="GeneID" id="100751314"/>
    <dbReference type="KEGG" id="cge:100751314"/>
    <dbReference type="OrthoDB" id="1870062at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15626">
        <property type="entry name" value="PHD_SP110_140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000028">
        <property type="entry name" value="Nuclear autoantigen Sp-100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000294">
        <property type="entry name" value="Nuclear autoantigen Sp-100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004865">
        <property type="entry name" value="HSR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043563">
        <property type="entry name" value="Sp110/Sp140/Sp140L-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46386">
        <property type="entry name" value="NUCLEAR BODY PROTEIN SP140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46386:SF1">
        <property type="entry name" value="NUCLEAR BODY PROTEIN SP140-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03172">
        <property type="entry name" value="HSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51414">
        <property type="entry name" value="HSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HSR" evidence="13">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SAND" evidence="12">
        <location>
            <begin position="314"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="424"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027253227.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="68640" checksum="3D12029BA873E42A" modified="2023-06-28" version="1">MARENDGSRSRSTPEGSVFEEESADYQLMFKRFKENKVEIASAITKPFPFLMSLRDRGFLSEQKFQNFKGSCQNLIPVERVVYDILSDLQNNFSLALLEVIFSPTHLKAYPDLQEILRVILNVSNNHRALQRINGRHAEDRPRLPAVVREASCSVGNSPMNGEQAEEVPNLPQCNGGEGSSSYEQMLDEQEPQGDLSSSPQRCEPGAEQSTSENEMCPCVMCSPAYKPEDREARMGNNQTDTLETRNNTKAGKSKGKRRKKRGHNWSKAKQRTALAKNYRGAGGQAAVRRRQRRSNPEGSARTVRRRGPRKPRTQNADFSAALLPVTCGTVKGVLHKEKFKQGISVKSIQSEDGDWYTPIEFEILGGFGRSKNWKLSLRCYNWPLKSLIQKDFLPNCPRKYGKRKKKNTQNLYSSPANACMQNSDECEVCQDVGILFCCDTCSRAFHEECHIPTVEAEITPWSCIFCRIQSLESQQSLPESEVLQRQMVAQEQLKCEFVLLSIYCCSESSFFSKIPYYYYFRETPMGVKKPMWLDLIKKKLRERDYSHVEGFVQDMRLIFHNHRTTFKEPKFGQMGLRLESEFEKNFKKVFAIQDSNGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FD23</accession>
    <name>A0A9J7FD23_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maestro heat-like repeat-containing protein family member 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Mroh2b</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003503337.1">
        <property type="nucleotide sequence ID" value="XM_003503289.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257175.1">
        <property type="nucleotide sequence ID" value="XM_027401374.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100767277"/>
    <dbReference type="KEGG" id="cge:100767277"/>
    <dbReference type="CTD" id="133558"/>
    <dbReference type="OMA" id="HREDFCE"/>
    <dbReference type="OrthoDB" id="1884734at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000841">
        <property type="entry name" value="Maestro heat like repeat family member 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF22">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="4">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="3">
        <location>
            <begin position="217"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="2">
        <location>
            <begin position="899"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="5">
        <location>
            <begin position="1302"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027257175.1"/>
        </source>
    </evidence>
    <sequence length="1581" mass="180911" checksum="5CF3B142BDE6F6FB" modified="2023-06-28" version="1">MEEYTDMFGDINLTIGMLSKEDNISKEDIYSHLASFIQNTDILDDAIVQKLIYYTSKDMRDEDIPREIRMLAGEVLVSLAAHDFNSVMYEVQSNFRILELPNEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLVEDENMKQTFCIALEKFSKAIYKYVNHWKEFPYPKLDAHRLSDKIFMLFRYIMEKWAPQASPMNTLTIVKVHGPTVSLLLHREDFHEYALSQVPWLLTQYKDKESDFYITQSLKQILTAAVLYDIVLPKNLRRSTLTSLLHQVCRLPEPPIKENKIEASSCFLILAHANPADLLEFLDEHIRSNNEAVRTGILTLLRSTIYVEEPRFRNHTTSIENMVKVVMSDLNVKVRKSTLLLIQTMCERGYIEAREGWPLIDYIFSQFAMSNRNLEKAMKSNSQDEEKEEKFVQETSLEVLKSLDPLMIGMPQVLWPRILTFVVPEEYTGTLGYLFNIIRILVMAEEKKKRDIQESTALVISTGAVKLPSPQQLLARLLVIAVLASLGQLCGASAIGLLKIVPEIIHPKLVDLWKTRLPELLKPLEGNNSSIVLWETMLLQLLKESLWKISDEAWTSQLSRDFIRQMDSYSNSSIEKKFLWKALGTTLASCQDTDFVSSQIREFLVSPSQLGDQRQGTTSILGYCSEKHLDTVLKVLKTFQEKEKFFINRCKGIFSGKKSLSKIDLILIYGALALHAPKQELLARLDEDIMSQILLLYNQCSQVLGVSVVNKDMDLQMSFTRSITEVGIAIQDAEDFKFQFTYKEMLIGFMLDSIKEEPLNSLASPVRWKALIAIRYLSKLKPQLSLNDHLNILEENIRRLLPLPPLEKLKSGGETDKDKERIEFLHERSMDALGKLLRSMIWDDTDAQNCEEMFNLLRMWLVSQKEWERERAFQITSKILTNDIEAPKNFRIGSLLGLLAPHSCDTLPTIRQAATSSTIGLFCAKGICLEVDRLQGLQEGLESNDEQVQIKISSKIAKIVCKFIPNEEIQAFLEETLDGLETLNPMCTKACGIWMIAALKEHGAVLEDQLLEILNTTYHHMPVLRQKEESFQFILEAISQIASFHMDSVVVNLLQKPLPFDRDTKTLWKSLAENPASRGKLMRALIKKLDARLEDDIAGIDAISVACAMYEVILTGTHVTHLYPELFTLLLKLVSCSLGQKMPTSTLSQRRRVMQLGERQQTPDPCRLSTAALKCLQAQAMKEGLAKESDEGDNLWNLLSNPDTHHIGVCALARSMAVWQHGVILDIMQHLFSSLTSSSENYRITGTAFFSELMKEPILWKHGNLRDVLVFMDQSAWDSNAVLRQMAIRGLGNTAHGAPHKVKKHKQIMLESIIRGLYHLARTEVVCESLKALKKILELLTERDISFYFKEIVLQTRTFFEDEQDDVRLTAISLFEDLASLTGRRWKVFFAEEVKKSMISFLLHLWDPNPKIGAACRDVLVICIPFLGLQELYGILEHLLEQDLPRARDFYRQFCMKLAKKNQEILWILHTHSFTFFTSSWEMIRSAAVKLTDAIILHLTSQYVELLDREQLTMRLQALRQDPCISVQRASEAALQTLLRRCKETSIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FDV1</accession>
    <name>A0A9J7FDV1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 7</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cell division protein kinase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">TFIIH basal transcription factor complex kinase subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 28" type="primary">Cdk7</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27 28">17A/GY</strain>
            <tissue evidence="27 28">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI. Interacts with HINT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027257403.1">
        <property type="nucleotide sequence ID" value="XM_027401602.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257404.1">
        <property type="nucleotide sequence ID" value="XM_027401603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FDV1"/>
    <dbReference type="GeneID" id="100769780"/>
    <dbReference type="KEGG" id="cge:100769780"/>
    <dbReference type="CTD" id="1022"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000190">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 22 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 27 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 22 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 24" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="12"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027257403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027257404.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40143" checksum="7EF5C32CE4CA9B3C" modified="2023-06-28" version="1">MAVDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLQHIFIAAGDDLLDLIQGLFLFNPCTRITASQALKTKYFSNRPGPTPGCQLPRPNCPAEALKEQSNPAMATKRKRTEALEQASRIVRVTGMFHHSELLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FE17</accession>
    <name>A0A9J7FE17_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Amine oxidase</fullName>
            <ecNumber evidence="16">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC100753207</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an L-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="1.4.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family. FIG1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_003502731.1">
        <property type="nucleotide sequence ID" value="XM_003502683.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254811.1">
        <property type="nucleotide sequence ID" value="XM_027399010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FE17"/>
    <dbReference type="GeneID" id="100753207"/>
    <dbReference type="KEGG" id="cge:100753207"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:toxin activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:defense response to bacterium"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF355">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039919161" description="Amine oxidase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="18">
        <location>
            <begin position="62"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047637"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027254811.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="57939" checksum="93403A18FDBD5378" modified="2023-06-28" version="1">MAKRSGIFILGILLSMPSCLAFYEDLDKCFQDPDYNTFLLTAQNGLHTSPLPKRVVVVGAGIAGLVAAKTLQDAGHKVTILEASDYIGGRILTVRNKKEGWYIDLGPMRIPESHKLIHTYVKKLGLKLNKFIQYDNNTWYLLNGRRYRAWEVKANPGILGYPTSPTEKSKTAQYLFQQAITKIKQRMKTLNCSQLMSICDSYSTKAYLTKEGMLSKGAIEMIGDMMNENAGYYKSLLESLRMASIFSRNDEFSEIVGGFDQLPHGISASLKPGTIHLRSRVETVVRHGPKVEVLYRTDGPTSPLHKLTADFIINSASAKATRLISFQPPLSSDKTHALRSVHYTSATKVALVCNKRFWEQDGIQGGHSITDRPSRYIYYPSHRLPGGKGVLLASYTVDDDSLFFAAMKPSQVVNIILDDLAAVHHIPKEELKHMCPKSVVKRWSLDPLVIGAFTEFTPYQFVDYSKKLFQPEGRIHFAGEHTSLPHGWIDTAIKSGIRAAKNIQAMVDKEVTQGQRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FE79</accession>
    <name>A0A9J7FE79_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription factor 3C polypeptide 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transcription factor IIIC 35 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Transcription factor IIIC subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Gtf3c6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with GTF3C4 and GTF3C5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TFIIIC subunit 6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007643595.1">
        <property type="nucleotide sequence ID" value="XM_007645405.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257979.1">
        <property type="nucleotide sequence ID" value="XM_027402178.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FE79"/>
    <dbReference type="GeneID" id="100770634"/>
    <dbReference type="KEGG" id="cge:100770634"/>
    <dbReference type="CTD" id="112495"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4370:FF:000001">
        <property type="entry name" value="general transcription factor 3C polypeptide 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="12">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027257979.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26050" checksum="212CDC1E59ECC695" modified="2023-06-28" version="1">MASPSVRAMASAMDPSWEEEEEDEDEEEEIEEVEQFVLVELSGIIDSDFLSKCENKCKILGIDTEKPILQVDSYVFAGEYEDTLGTCVIFEEGVERVDPEGTDKTVLKYKCHTMKKLSMTRTLLTEKKEGEENIDGVEWLQMKDNDFSYRPNMICSFLHENEDEAVAPAPEKAVELEDQEAQMKGSTEQTHEQERVQYLEAGDPGPLGDVPAEMGSSVSMGIQGGDISQNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FM64</accession>
    <name>A0A9J7FM64_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC1 domain family member 12 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Tbc1d12</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027263227.1">
        <property type="nucleotide sequence ID" value="XM_027407426.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FM64"/>
    <dbReference type="GeneID" id="100756724"/>
    <dbReference type="KEGG" id="cge:100756724"/>
    <dbReference type="CTD" id="23232"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000008">
        <property type="entry name" value="Putative TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000005">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000006">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="393"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027263227.1"/>
        </source>
    </evidence>
    <sequence length="684" mass="75691" checksum="0F43164330830D90" modified="2023-06-28" version="1">MMGPEDAGACSGRNAELLPVPGPMGQDGKTVLAAGGFGGGAVAAESPGEAGEEEAPRPRQLLQRYLAAAAGPLQPGLGGAESAAVPEACHSGMTNGDSGFLLRQGRRRRSCGHPRLPEPADLGVDGAGGPDDWAAPLEDPLRSCCLAAGDTDDPEPTAATSAARVGGSAEPSPGLPDARLSSRNTFEVSRRQSASDLLPSAGSPAPPPAAEQGPGGSTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKVPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMRERFKQEESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRARERWKSFSETSSDNDIEGISVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVTKDIKEGERNSSPPLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FP03</accession>
    <name>A0A9J7FP03_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 431 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100770581</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262642.2">
        <property type="nucleotide sequence ID" value="XM_027406841.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FP03"/>
    <dbReference type="GeneID" id="100770581"/>
    <dbReference type="KEGG" id="cge:100770581"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001530">
        <property type="entry name" value="Zinc finger protein 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000522">
        <property type="entry name" value="zinc finger protein 285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000187">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001442">
        <property type="entry name" value="zinc finger protein 696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000787">
        <property type="entry name" value="Zinc finger protein 784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FZV6</accession>
    <name>A0A9J7FZV6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Creatine kinase B-type</fullName>
            <ecNumber evidence="2">2.7.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Creatine kinase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Ckb</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>creatine + ATP = N-phosphocreatine + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57947"/>
            <dbReference type="ChEBI" id="CHEBI:58092"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17158"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. Interacts with SLC12A6 (via C-terminus); the interaction may be required for SLC12A6 potassium-chloride cotransport activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 14">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-guanido_PTrfase"/>
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        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
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        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
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        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
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        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
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        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF23">
        <property type="entry name" value="CREATINE KINASE B-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="16">
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            <begin position="11"/>
            <end position="98"/>
        </location>
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            <end position="367"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="96"/>
            <end position="122"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
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            <end position="110"/>
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    </feature>
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            <begin position="128"/>
            <end position="132"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <position position="191"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <position position="236"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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        <location>
            <begin position="320"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012231"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040306"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041818"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045554"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048857"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027272538.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42756" checksum="1E4BC32BE2756EB6" modified="2023-06-28" version="1">MPFSNSHNTQKLRFPAEDEFPDLSSHNNHMAKVLTPELYAELRAKCTPSGFTLDDAIQTGVDNPGHPYIMTVGAVAGDEETYDVFKDLFDPIIEDRHGGYQPSDEHKTDLNPENLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLSGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIENLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNSDRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G0M1</accession>
    <name>A0A9J7G0M1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptor 161</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">Gpr161</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21">17A/GY</strain>
            <tissue evidence="20 21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272940.1">
        <property type="nucleotide sequence ID" value="XM_027417139.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272941.1">
        <property type="nucleotide sequence ID" value="XM_027417140.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311644.1">
        <property type="nucleotide sequence ID" value="XM_035455753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G0M1"/>
    <dbReference type="GeneID" id="113830667"/>
    <dbReference type="KEGG" id="cge:113830667"/>
    <dbReference type="CTD" id="23432"/>
    <dbReference type="OrthoDB" id="5980076at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15214">
        <property type="entry name" value="7tmA_GPR161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000091">
        <property type="entry name" value="G-protein coupled receptor 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="43"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027272940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027272941.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="58742" checksum="F52FB772BD391B53" modified="2023-06-28" version="1">MSLNSSPHYRKELSNLTATEGGEGGVVTEFIAIIIITVFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSCIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSLEFDEFKWMCVAAWHREPGYTVFWQIWCALFPFLIMLVCYGFIFRVARVKARKVHCGSVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVIGAFMVTWGPYMVVITSEALWGKNYVSPTLETWATWLSFTSAICHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQSLGHSSSTGDTGFSYSQDSGTDVMLLEDCTSDDNPPPHCTCPPRRRSSVTFEDEVEQSKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLLTARTVPGASFGGRRGSRTLLNQRLPLQSIEEGDILAAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G1M2</accession>
    <name>A0A9J7G1M2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Interferon alpha-inducible protein 27-like protein 2B isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100763130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272241.1">
        <property type="nucleotide sequence ID" value="XM_027416440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G1M2"/>
    <dbReference type="GeneID" id="100763130"/>
    <dbReference type="KEGG" id="cge:100763130"/>
    <dbReference type="OrthoDB" id="9948818at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF30">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027272241.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="24819" checksum="CE14453A5B8BD29F" modified="2023-06-28" version="1">MKPISLAAFHHPVFFKQNGFFRIGENRKKQNLSHWLPWITGCVLNKSGFFRPGETREEGNQLIGCLASLGVGCVWNLSMALFGTGVRMASLVSRITASVAIVKAGGTVSGTILAGSRGLNLLAQTALGSGASALGSSLGALKVGTILSVCPASVLAVGPTAAKAAAAVLGGAITVAAVPPVLSAVGFTGAGIAASSLAAKMMSLSAIANGGGVAAGGLVATLQSVGAAGLSMSSKLLLGSAGSTLMARVMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G3A3</accession>
    <name>A0A9J7G3A3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CUGBP Elav-like family member 5 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Celf5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027275026.1">
        <property type="nucleotide sequence ID" value="XM_027419225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G3A3"/>
    <dbReference type="GeneID" id="100770452"/>
    <dbReference type="KEGG" id="cge:100770452"/>
    <dbReference type="CTD" id="60680"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12632">
        <property type="entry name" value="RRM1_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12635">
        <property type="entry name" value="RRM2_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12639">
        <property type="entry name" value="RRM3_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000007">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000010">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000069">
        <property type="entry name" value="CUGBP Elav-like family member 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034648">
        <property type="entry name" value="CELF3/4/5/6_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="361"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027275026.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="48279" checksum="4D329A133088E895" modified="2023-06-28" version="1">MKDLDAIKLFVGQIPRHLHEQDLKPLFEQFGRIYELTVLKDPHTGVHKGCAFLTYCARDSAIKAQTALHEQKTLPGMARPIQVKPADSESRGGRDRKLFVGMLNKQQSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAFVKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDRERTLRRMQQMVGQLGILTPSLTLPFSPYSAYAQALMQQQTTVLSTSGSYLSPGVAFPPCHIQQIGAVSLNGLPATPITPASGLHSPPLLGTAAVPGLVAPIPNAFPGVLPFPGSHPALETAYANGLVPYPAQSPTVAESLHPAFSGVQQYTAMYPTAAIAPVAHCVPQPPHLLQQQREGPEGCNLFIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDHPASAQAAIQAMNGFQIGMKRLKVQLKRPKDPGHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G462</accession>
    <name>A0A9J7G462_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histamine H3 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Hrh3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027275679.1">
        <property type="nucleotide sequence ID" value="XM_027419878.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G462"/>
    <dbReference type="GeneID" id="100764853"/>
    <dbReference type="KEGG" id="cge:100764853"/>
    <dbReference type="CTD" id="11255"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004969">
        <property type="term" value="F:histamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15296">
        <property type="entry name" value="7tmA_Histamine_H3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000138">
        <property type="entry name" value="histamine H3 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041998">
        <property type="entry name" value="7tmA_HRH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003980">
        <property type="entry name" value="Histamine_H3_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF194">
        <property type="entry name" value="HISTAMINE H3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01471">
        <property type="entry name" value="HISTAMINEH3R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 14 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="51"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="286"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027275679.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="48507" checksum="5968CE2FEA2CDC37" modified="2023-06-28" version="1">MERAPPDGLLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGAEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GH82</accession>
    <name>A0A9J7GH82_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Retinoic acid-induced protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Gprc5a</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027285694.1">
        <property type="nucleotide sequence ID" value="XM_027429893.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GH82"/>
    <dbReference type="GeneID" id="100751438"/>
    <dbReference type="KEGG" id="cge:100751438"/>
    <dbReference type="CTD" id="9052"/>
    <dbReference type="OrthoDB" id="8701926at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15279">
        <property type="entry name" value="7tmC_RAIG1_4_GPRC5A_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051753">
        <property type="entry name" value="RA-inducible_GPCR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14511">
        <property type="entry name" value="G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14511:SF7">
        <property type="entry name" value="RETINOIC ACID-INDUCED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="52"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027285694.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43375" checksum="099534216704C426" modified="2023-06-28" version="1">MPLRNLEIEAQTSHWLPLQRQPHCVTHAPGPTKMSAPRGCRSDLDPRYYRLCDLAEGWGIALETLAAVGAVATVAFMFALLVLISKVQDSNRRKVLPTQFLFLLGVLGIFGLTFAFIIKLDGDTGPTRFFLFGVLFAVCFSCLLAHAFDLIKLVRGRKPLSWLVILSLAVGFSLVQDVTAVEYLVLTMNRTNVDVFSELPAPRRNEDFVMLLIYVLLLMALTFLASLFVFCGSFPGWKRHGAHICFTSFLSIAIWVAWIVLLLIPDIGPEWDDTILCTALVANGWAFLAFYVFPEFLLLPKQRSPTDYPVEDAFCKPQLMKQSYGVENRAYSQEEITQGLEAGDTLYAPYSTHFQLQNRSPPKDFSIPRAQAPASPYNDYEGRKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GIG0</accession>
    <name>A0A9J7GIG0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial</fullName>
            <ecNumber evidence="11">3.1.3.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pyruvate dehydrogenase phosphatase catalytic subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100752399</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.43" evidence="11"/>
    <dbReference type="RefSeq" id="XP_027286530.2">
        <property type="nucleotide sequence ID" value="XM_027430729.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100752399"/>
    <dbReference type="KEGG" id="cge:100752399"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000006">
        <property type="entry name" value="Pyruvate dehyrogenase phosphatase catalytic subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF343">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="117"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027286530.2"/>
        </source>
    </evidence>
    <sequence length="514" mass="57506" checksum="3F4AD1FCAC7175A2" modified="2023-06-28" version="1">MXSTVSCQIFNSARNRIAVLQGGRRLYSRGASNRNQLKWRHFPHTSSTLKNRSPCGGFALQNAFRHTSTEEVDFHLQLSPEQVNDLLRAGKSSHKIFDFNNGVPNSVLRFENDRLAANSPAEDPQGVVASCMQINGLKFGIFDGHGGHACAQAVSERLFYYMAVSLMSQQTLGQMEEAMEENMKPLLPILQWLKHPGDSIYKDVTSVHLDHLRVYWXELLDLLMEMGLSIXEALMYSFQRPDSDISLEIQAPRKDEVTKNLSLQVAFAGGTACMAHVNGVHLHVANAGDCWAILGAQEDNSVWSCLPLTGXHNAWNEAELSQLKRKHPESEDRIFIMDDRLLGVLIPSRAFEDAEALNIYQFTPPHYYPPPYLTAKPEVTYHKLGPQDKFLVLVSDGLGDMLGNVDVVRLVVGHLSKVGCHKLDLDQRPANLGLMQSLPLQRKASGLRAAAQNAATXLITHAIGSNEYRDMDPERLDAILKLPEDVARMYQDDITVMVVFFFNSESIDTYYKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GL56</accession>
    <name>A0A9J7GL56_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligophrenin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100765371</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with HOMER1. Interacts with AMPA receptor complexes. Interacts with SH3GL2 (endophilin-A1). Interacts (via C-terminus) with NR1D1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Presynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027287512.1">
        <property type="nucleotide sequence ID" value="XM_027431711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GL56"/>
    <dbReference type="GeneID" id="100765371"/>
    <dbReference type="KEGG" id="cge:100765371"/>
    <dbReference type="OrthoDB" id="3183924at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901799">
        <property type="term" value="P:negative regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051966">
        <property type="term" value="P:regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01249">
        <property type="entry name" value="BAR-PH_GRAF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07633">
        <property type="entry name" value="BAR_OPHN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04374">
        <property type="entry name" value="RhoGAP_Graf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000183">
        <property type="entry name" value="Oligophrenin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000001">
        <property type="entry name" value="Rho GTPase-activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000008">
        <property type="entry name" value="Rho GTPase-activating protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047267">
        <property type="entry name" value="OPHN1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047225">
        <property type="entry name" value="PH_GRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF2">
        <property type="entry name" value="OLIGOPHRENIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="265"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="15">
        <location>
            <begin position="380"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="616"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="690"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027287512.1"/>
        </source>
    </evidence>
    <sequence length="812" mass="92593" checksum="F3A9713223BD5D35" modified="2023-06-28" version="1">MGHPPLEFSDCYLDSPDFRDRLKYYEQELERTNKFIKDVIKDGSALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVQNASDLLIKPLETFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLLEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETRTLTMTPTEQKPGAKQGPMDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQAPSEANRRLWMEAMDGKEPIYHSPITKQEEMELNEVGFKFVRKCINFIETKGIKTEGLYRTVGSNIQVQKLLNAFFVCAEGVSSSPDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYKLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEDSQVPPVPPPRVTARRHKPITISKRLLREKTVFYTSSLDENEDEAQRQTPNGTITSNLDTPKLPQHLKLPIQKSGETDLGRKSPNRPVSDSQPESCPEVDVGKLVFRLQDGGTKATPKATNGPVPGSGPTKTPPFPIKRQAPRPVAPHKEGDTDCFSKVRPPGEKQTIIRPPVRPPDPPCRASTSQKPEPKPDTVAGNAGEIPSSVVASRTRFFETASRKTGSSQGKLPGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GPQ8</accession>
    <name>A0A9J7GPQ8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZK1-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Pdzk1ip1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer (via N-terminal transmembrane helix) with SLC5A2/SGLT2 (via TM13); this interaction enhances SLC5A2 transporter activity. Interacts with PDZK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Apical cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PDZK1-interacting protein 1/SMIM24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294552.1">
        <property type="nucleotide sequence ID" value="XM_035438661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296330.1">
        <property type="nucleotide sequence ID" value="XM_035440439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759293"/>
    <dbReference type="KEGG" id="cge:100759293"/>
    <dbReference type="CTD" id="10158"/>
    <dbReference type="OrthoDB" id="9900654at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031627">
        <property type="entry name" value="PDZK1IP1/SMIM24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15296">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN MAP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15296:SF0">
        <property type="entry name" value="PDZK1-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15807">
        <property type="entry name" value="MAP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035294552.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21167" checksum="D060925798EF7EE0" modified="2023-06-28" version="1">MPICWAGHQPGLAAHFHEEGQFLFTSLPALPPRPLSLSVXPNRVSPSGPDCSPADLRQTPQTSSSSRSXKHQQWTKALQLPAAMLALSLLILGLLSSVAPASCQQGLGNLQPWMQGLIAVAVFLVLVAIAFAVNHFWCQDKPEPGSMVMIVGNKTDGVLAGMDGRYSSMAAGFRSTEHKNAFENVLEEEGRVRSTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GS70</accession>
    <name>A0A9J7GS70_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 40-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113834161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035295021.1">
        <property type="nucleotide sequence ID" value="XM_035439130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GS70"/>
    <dbReference type="GeneID" id="113834161"/>
    <dbReference type="KEGG" id="cge:113834161"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039195">
        <property type="entry name" value="ANKRD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192:SF1">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035295021.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36861" checksum="00AACAFD97AF1B60" modified="2023-06-28" version="1">MNALREQKEKQERMREAAALGDIREVQKLVESGVNVNSQNEINGWTCLHWACKCNHGQVVSYLLKSGADREILTAKGEMPVQLTSRREIRKLMGVEDDDDDDELPQLKESELPFVPNYLANPAFPFIHSPAAEDSTQLQNRGSSTPPASPPTDGSPPLLPPTEPPQLGAFPRAHTSLALVQNSDISAPSSILRTPENTKPSPVGQPPVSQNRSSVPPKPPVSLEPQNGTLAGPAPAFQPFFFTGALPFNTKELVLKVRIQNPSLQENDFIEIELDRQELTYQELLRMSCCELGVNPDQVKKIRKLPNTLLRKDKDVARLQDFQELELVLNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H215</accession>
    <name>A0A9J7H215_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC113831730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC113831730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035301789.1">
        <property type="nucleotide sequence ID" value="XM_035445898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H215"/>
    <dbReference type="GeneID" id="113831730"/>
    <dbReference type="KEGG" id="cge:113831730"/>
    <dbReference type="OrthoDB" id="9590488at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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                <person name="Samoudi M."/>
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                <person name="Lee K.H."/>
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                <person name="Dhiman H."/>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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                <person name="Samoudi M."/>
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            <strain evidence="14">17A/GY</strain>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035304618.1">
        <property type="nucleotide sequence ID" value="XM_035448727.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317152.1">
        <property type="nucleotide sequence ID" value="XM_035461261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H8J0"/>
    <dbReference type="GeneID" id="100750511"/>
    <dbReference type="KEGG" id="cge:100750511"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013600">
        <property type="entry name" value="Ly49_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052013">
        <property type="entry name" value="Mouse_KLRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46329">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46329:SF1">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08391">
        <property type="entry name" value="Ly49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="13">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035304618.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="27028" checksum="C05278B13B1843B6" modified="2023-06-28" version="1">MSDEEITYTTVRFHKSSSGLQSRRRPDETQGPREYAQGESSVPWLHTVIPLGILCFILLVTVAVLGTFIFQCRQEKHELQKNLTNINQTYSVMQNNRGLNEMLRNNTTECDDFKYQEEQISGRINLNREQNRFCRETKVDIDCKEHTGKRVEAQWFCCGIKCYYFIMDNKHWNGCKQTCEDCSLSLLKIHDYDELKFLKPRLTTNSYWIGLSYNKSKRKWQWVGGGPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H8V0</accession>
    <name>A0A9J7H8V0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 585A isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Znf585a</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305377.1">
        <property type="nucleotide sequence ID" value="XM_035449486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H8V0"/>
    <dbReference type="GeneID" id="103161320"/>
    <dbReference type="KEGG" id="cge:103161320"/>
    <dbReference type="CTD" id="199704"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000622">
        <property type="entry name" value="zinc finger protein 26 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000128">
        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000268">
        <property type="entry name" value="zinc finger protein 484 isoform X2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000754">
        <property type="entry name" value="Zinc finger protein 585A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001377">
        <property type="entry name" value="Zinc finger protein 585A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001396">
        <property type="entry name" value="Zinc finger protein 585A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001475">
        <property type="entry name" value="Zinc finger protein 585A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF139">
        <property type="entry name" value="ZINC FINGER PROTEIN 615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035305377.1"/>
        </source>
    </evidence>
    <sequence length="880" mass="100143" checksum="899E0EBB5EAE1B82" modified="2023-06-28" version="1">MLSARDWPPGRPEVALVLEGGFLPALPLLSLYAMNSMNNETSSGWTRLVSSVESAARVDGSVSFMDVTVNFSREEWQHLGPDQRSLYRDVMQETYSPLCSVEELQQIGDQKETYRQLENISGSDVIFIKKTLNTKNRYGCKTIRKIIHVNPYIVLPSTRPHQCDSFGNDLKHNLDLQSHNENNGPKRIKKIAEYGKILSYTNTEHTAAREKLWNKNQCGKVLNYEQVPCQYQNIYVDRKAYECAESGRSFTQKSQLKVHMKSQTGDKLYVCGECGKAFSQKPELIVHQKTHTREKPYKCSDCEKSFFQVSSLFRHQRIHTGEKLYECRECGKGFSYNSDLSIHQKIHTGERHHECIDCGKAFTQKSTLKMHQKIHTGERSYVCIECGQAFIQKTHLVAHQRVHTGEKPYGCNNCGKSFISRSQLQAHQRIHTRVRPSISAEYGETLSSSSNLLTRKKVQVREKSSICTDCGKAFTYKSELIIHQRSHTGEKPYQCGDCGKAFTQKSALTVHQRIHTGEKSHVCMKCGLAFIQKAHLVAHQIIHTGEKPYKCGHCGKHFTSKPQLHVHKRIHTGEKPYTCSQCGKAFTNRSNLSTHQKTHTGEKAYVCSNCEKAFTQRSDLIIHQRTHTGEKPYSCNTCGKAFTQKSHLNIHQKIHTGERQYKCHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGKAFSGRSNLSKHQKTHTGEKPYVCSECGKTFRQKSELITHHRIHTGEKPYECSECGKSFTKKSQLQVHRRIHTGEKPYVCVECGKAFTDRSNLNKHQTTHTGDKPYKCPVCGKGFVQKSVLSVHQSIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HA09</accession>
    <name>A0A9J7HA09_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Achaete-scute homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ascl1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035306619.1">
        <property type="nucleotide sequence ID" value="XM_035450728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HA09"/>
    <dbReference type="GeneID" id="100772145"/>
    <dbReference type="KEGG" id="cge:100772145"/>
    <dbReference type="CTD" id="429"/>
    <dbReference type="OrthoDB" id="5976910at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19742">
        <property type="entry name" value="bHLH_TS_ASCL1_Mash1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000029">
        <property type="entry name" value="Achaete-scute family bHLH transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF153">
        <property type="entry name" value="ACHAETE-SCUTE FAMILY BHLH TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035306619.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25479" checksum="F977F504AAC3B97E" modified="2023-06-28" version="1">MEGSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAQSAQQQQQQQQQQQPPPQPQQAPQLSPVADGQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDMNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HBK2</accession>
    <name>A0A9J7HBK2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein of 68 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">Cep68</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11 12">17A/GY</strain>
            <tissue evidence="11 12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with CNTLN; the interaction recruits CEP68 to the centrosome. Interacts with the SCF(FBXW11) complex which contains SKP1, CUL1 and FBXW11; the interaction is probably mediated by FBXW11 and the complex also contains CDK5RAP2 and PCNT. Also interacts with F-box protein BTRC. Interacts with serine/threonine-protein kinase PLK1; the interaction leads to phosphorylation of CEP68 and its subsequent degradation. Interacts with NEK2; the interaction leads to phosphorylation of CEP68.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027243865.1">
        <property type="nucleotide sequence ID" value="XM_027388064.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309115.1">
        <property type="nucleotide sequence ID" value="XM_035453224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HBK2"/>
    <dbReference type="GeneID" id="100754661"/>
    <dbReference type="KEGG" id="cge:100754661"/>
    <dbReference type="CTD" id="23177"/>
    <dbReference type="OrthoDB" id="9448174at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000296">
        <property type="entry name" value="centrosomal protein of 68 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027243865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035309115.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="78802" checksum="B76BE66F3D968DD4" modified="2023-06-28" version="1">MALGEDVAEANTSVNTKVQSCGRWNSVEQELLPPGLDPQQPPHLEVKRGPRCRAEADPGCISRVFESQAHTASGEPVADGSKSTLSGPLPSVSMGTGDLHSVGNHMEEKKLPASHDLCQRVKVIGTVTVCSGHDAASEDNQSPVDCHQVLGLSQQPHISGFPLLSQWKSTVSPGAPQLSSASSMGSSLQDHQEKAEPQSSSFAKVSSQELIVPQGAPSVVGTGPQPLWSSQPVAPGSDATSLGKRQLSFQAEYWACVLPNSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKQFESLVLTDPVMQDSGVDLDSFSVSPASTLKSPTNVSHNCLAAEVPTLPFSGAREPCLKNWPLGVSQKQDGISLPSWNQLTSTPRTLGTEDASCKNREAALRDTKNYLPIGKNLSVGSPQLRMKERAPPFPRLEKEKRAYQTVGHPACVKPAWTSEEEMESDDEYLALPTRLTPVSSLMSYLGVIPTFVNLPTGAAEECSSLIVSDSDGPVSSTLDSSQRQHPSGAAFQGPVVQNSCFVDSIHPKDSTGKSSKVSSQALGVSSGLLHAHPSLQAASDRWPFSEPVAGENLPRNRGQEKASLVQCVQTFCCQLEELICWLYNVTDVADLSTPPRSTLTGLKSSLQLYRQFKKDIDKHQSLTENVLEKGEILLQCLMDNTPVLKDVLGKIAKQSGELESHADHLYDSILASLDMLAGCTLIPDNRPAAAKEHPREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCU7</accession>
    <name>A0A9J7HCU7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein 2A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Sh2d2a</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035307802.1">
        <property type="nucleotide sequence ID" value="XM_035451911.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312071.1">
        <property type="nucleotide sequence ID" value="XM_035456180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCU7"/>
    <dbReference type="GeneID" id="100751565"/>
    <dbReference type="KEGG" id="cge:100751565"/>
    <dbReference type="CTD" id="9047"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10416">
        <property type="entry name" value="SH2_SH2D2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000144">
        <property type="entry name" value="SH2 domain protein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035884">
        <property type="entry name" value="SH2D2A_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF9">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035307802.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41086" checksum="008F30B26051A859" modified="2023-06-28" version="1">MEFCLAQTCPQGNHEAPSPTFSTFQPMNLTQGRCQELGWGSKPSMQAPKEEKAQLSPRATHTMVSKSMEGNAWVLGNADKEEEVPGKGGLSLQAETREWVQKTQAHWLLLKTAPVWFHGFITRREAERLLQPQPQGCYLVRFSESAVTFVLSYRSRTCCRHFLLAQLGDGRHVVLGEDSAHAQLQDLLQHYTECPLSPYGEMLTQPLARQTAEPAGLFMRTESVSGSKRQEDPDSQHSLLIQQGQAQAPAHKEKVWASQPKGTSPRPRPPIPAKPLLPLEVYTSPASRSRRAPPTNPIYQEPDEPIAFYAMGRGSPGEAPSNIYAEVEGPSGMAPTGHPILQKCWSRPISGGQVKGAQGKKNSRRPAERGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J2F9</accession>
    <name>A0A9J7J2F9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100774112</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003507467.1">
        <property type="nucleotide sequence ID" value="XM_003507419.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244474.1">
        <property type="nucleotide sequence ID" value="XM_027388673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J2F9"/>
    <dbReference type="GeneID" id="100774112"/>
    <dbReference type="KEGG" id="cge:100774112"/>
    <dbReference type="OrthoDB" id="6145535at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15915">
        <property type="entry name" value="7tmA_OR12D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="39"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027244474.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35932" checksum="3166AF4231A4B314" modified="2023-06-28" version="1">MENATSVDGFLLLGLTSVQELQPVFFVMFLIIYLLNLVGNGLILVIITLERRLHSPMYFFLGNLSCLDICYSSVTLPKVLINLLFRHRTISFLGCITQLHFFHFLGSTEAILLAVMAFDRFVAICNPLRYTAIMNPQLCLLLAAMAWTTSFFYALMHSVMTAQLNFCHSHKLSHFFCDVKPLLEVACDNQWLLSVVTGSISMGAFLLTLLSYFYIIAFLLFKNLSFRMLRRALSTCTSHFMVVCLFYGPVGFTYIRPTAASASSMSEDRMVAIIYSAVTPVLNPLIYTLRNKEVMLALKKLFGKLFKDHQLHGGDQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J6N1</accession>
    <name>A0A9J7J6N1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Maestro heat-like repeat-containing protein family member 2A isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Mroh2a</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007651791.2">
        <property type="nucleotide sequence ID" value="XM_007653601.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251790.1">
        <property type="nucleotide sequence ID" value="XM_027395989.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100756011"/>
    <dbReference type="KEGG" id="cge:100756011"/>
    <dbReference type="CTD" id="339766"/>
    <dbReference type="OMA" id="HHNPEVK"/>
    <dbReference type="OrthoDB" id="1884734at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF14">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="5">
        <location>
            <begin position="66"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="4">
        <location>
            <begin position="286"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="3">
        <location>
            <begin position="959"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="6">
        <location>
            <begin position="1387"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027251790.1"/>
        </source>
    </evidence>
    <sequence length="1671" mass="189018" checksum="75C0C9828125BADD" modified="2023-06-28" version="1">MEKAATKLNEDMEETEHHGPLEPEDDGTFFQVTNLLNIMDSESTKTDTTGPGLDMRKTLASVIITEKATTDPCVVMNALIRCLQMPETSTQRKMIIYNILQEIIQQEGELEEHCVQRLVAIASKEMRDTTEMEGFETAEVASETLVALSRNHFSLVMYELQHHLKPLNLTDEFVIVTLAKLANGNVFEFMPYMGITLATIFTMLRLANEAKMRQVICSAMETFCETVQFYLRHLEDSLYPVMTEDQFAVKLFPMYRYFVTVWLRHQDLEVKLGVIKSLRPMLSLLLPNDDLREQVYDYIPLLLAEFQGGLEALFITQVLRQILEASVTTSTPIPPMLLHPIFTELHVQVCTKAPAQQQFSSQNLMEIVHCFIALARSYPKELMKFFFSQVEMSKEAIRVGTLALIRAVVSADDPKMNIKTIYLAIRVVKNTLSDTRSKVRMAILRIIGQLVLSGFQEKIKGWGLKYVSVQLTLSTYKLTNRRECFYQRDLEEKMVHKVTMDTVKIITSSISGMTNEFWVRLLCYIMETDYTEALTPICISLTNLAENQIHGKDTEAGMAGKSKHVDLPAPQKLLARLLVLMSSPYKGEGRGIAMLNLLRTLSQSIAPSMADMWEQEIPLLVQYLEEHTEFTWNQKVWEDKLIQFLRNSLKKTRGTSWSLRLSKELNNQIETFDSPSLEKGFLYRALGFTLGMGLEADRVEVLLLELLYKTDYSNDFDREGVILCFGLCARGQVKTVLNVLHDFEERIQESEQSWQIGAWRKDHPWRRETVKCALMVMYSCVSSYCHPQMLLTHVDNPITAKIVHHYSSSCQDISLKMAFMKSVVEVTNAIKSIKDLEEFQFTHKSALTSLIVAIIKAEPPDHLASPVRSMAMDALSKLSTLKPFYSSEESIELMDISIHTVISLQPPGEDNDSIKTLYANALNSLKQLMEGLLQRQLDPKGLQETVHLLEKWILSEKEWEREKAMSLHLHLMQIYVQSIGVCIPLKLGQFGILVGLIAPCTCDVHRRTRLASTNVLSSLLDLHVSQTCSLWGASKEQELERCKEDLQETDMDKISSASSRIAKVVCPEFNCDEVVSLIQKLCENIGAMDLQHDRAAVTWIGIFLQMRVKELEDKVAEILGAILVHLPVVDHPEVRRHLIEGILLLAHYHQETVLTSLLRQPLPMESHLTEVWLAVAENVPFARTMLHGLLGRLQSRFTARINATSKADIWRLAAVDPLMTLCTIRLLMEKMDQDDKFPDLFPDLLYTFLLQLGSSHGPEAASPVLKTWRLVHTGPLPQEMTLQRITIKSMQLLVKRINREPLEQALEEQSVWSLLENGGTFLEGLSLMARLCLQNAESYTQRLAELVLTGMGSEVLSCCISSTAICVEFMSDPVLHQEKLLRPVVLMLEKGAGQDKDEILQVLSLRALGNMALGAPRKVKQYRKLLLEKCLGSLQGQVSCSVMAEGMEALTKILAELREGDIGSSFEPISQQCRAFFDNESELIRLKAFILFGKLAKVVGISKKHFFKGEVKRGWVSLMLHCQDPCPSVAQACLATMFQCVHFWGWKSLESSFGHSNDSINDQMTVFQTNMCSVLAQKKPIVLCGFLVETTIFMKSNLSSIRISACALAGIIMKQLSAHFLKKMDLVGLRNSLQDLQLDSDAGVRRAALETLKVLDSCNQHWLLASPRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J727</accession>
    <name>A0A9J7J727_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Sec62</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027247846.1">
        <property type="nucleotide sequence ID" value="XM_027392045.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293147.1">
        <property type="nucleotide sequence ID" value="XM_027437346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J727"/>
    <dbReference type="GeneID" id="100769200"/>
    <dbReference type="CTD" id="7095"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027247846.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48928" checksum="18FFDFFE5F65F153" modified="2023-06-28" version="1">MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKGEEALFTTRESVVEYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKSESGKEDDKKSKKETVKEEKTKKEKEKKKDGEKEESKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHIKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAIARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDERSETKKQHKSDSEEKSDSEKKEDEEEKASGNHGTDGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCDEEDDDKDGELRKSKLNCTFNTEKGGHLQQKVKSTDCEDSSFIPISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JEG9</accession>
    <name>A0A9J7JEG9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H1.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100774468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027265300.1">
        <property type="nucleotide sequence ID" value="XM_027409499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JEG9"/>
    <dbReference type="GeneID" id="100774468"/>
    <dbReference type="KEGG" id="cge:100774468"/>
    <dbReference type="OrthoDB" id="9634976at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000075">
        <property type="entry name" value="Histone H1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0164">Citrullination</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027265300.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="22038" checksum="55A96CFAF471F996" modified="2023-06-28" version="1">MSETAPAAPAAPAPVEKTPVKKKAKKTGAAAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAKKPKKATGSATPKKAAKKTPKKAKKPAAAAGAKKVAKSPKKVKAAKPKKTAKSPAKAKSPKPKAAKPKATKPKAAKAKKAAPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JJP5</accession>
    <name>A0A9J7JJP5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100765771</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263820.1">
        <property type="nucleotide sequence ID" value="XM_027408019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JJP5"/>
    <dbReference type="GeneID" id="100765771"/>
    <dbReference type="KEGG" id="cge:100765771"/>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF54">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027263820.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35834" checksum="C8C59B5FD5B2330E" modified="2023-06-28" version="1">MAMFNGSVFMPSVLTLVGIPGLELVQCWIGIPFCIMYIIALIGNSLILVIIKSEKSLHIPMYIFLAILAVTDIALSTCILPKMLGIFWFHMPQISFDTCLLQMELIHSFQATESGILLAMALDRYVAICNPLRHATIFSTQLMTCLGASVLLRSLILTFPMILLIKCRVKYYRTTIVSHSYCEHMAIVKLAAEDVRINKVCGLLVAFAILGFDIVFITFSYVRIFITVFQLPQKEARLKAFNTCIAHICVFLQFYLLGFFSFFTHRFGAHIPSYVHILQSDLYLLVPPFLNPIVYGVKTKQIREQVLKTLFSKKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JLC1</accession>
    <name>A0A9J7JLC1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100751946</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027277004.1">
        <property type="nucleotide sequence ID" value="XM_027421203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JLC1"/>
    <dbReference type="GeneID" id="100751946"/>
    <dbReference type="KEGG" id="cge:100751946"/>
    <dbReference type="OrthoDB" id="9011197at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15413">
        <property type="entry name" value="7tmA_OR8K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027277004.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35692" checksum="358FBD55EA7AA3F9" modified="2023-06-28" version="1">MAHINCTEVTEFILVGLTNRQELKMPLFVVFLAIYLFTTVGNLGLILVIRTDARLNTPMYFFLSNLAFVDFCYSSVITPKMLGNFLYQKNVISFNSCAAQLGCFLAFMTAECLLLASMAYDRYVAICNPLLYMVLMSPGICLQLVAAPYCYSFLVALFHAILTFRLCYCHSNIINHYYCDDMPLLRLTCSDTHSKQLWIFVCAGIMFISSLLIVFISYTFIISAILRMRSAEGRRKAFSTCGSHMLAVTIFYGTLIFMYLQPSSNHSLDTDKMASVFYTVIIPMLNPLIYSLRNKEVKDALKKLIISRNQTFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JNT2</accession>
    <name>A0A9J7JNT2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113835854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_027272773.1">
        <property type="nucleotide sequence ID" value="XM_027416972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JNT2"/>
    <dbReference type="GeneID" id="113835854"/>
    <dbReference type="KEGG" id="cge:113835854"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF85">
        <property type="entry name" value="RIKEN CDNA 1810024B03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="530"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027272773.1"/>
        </source>
    </evidence>
    <sequence length="739" mass="82649" checksum="10C7E8675FA41D17" modified="2023-06-28" version="1">MDITNKFTNKSSEKVQIQLDLKASASEEETLSDHYVILRSLGKGNFAEVKLAYHLHTEVQVAVKVLQNGTKNDFSIKTEIDMYKTLDHPNIIKLFHIINIKEYTYIVLEHAARGDLVSYIGRVGRLQEEQAQHIFTQLVCAVHYCHDSGIAHRDIKLDNILLDDKGNIKLCDFGLATRVTPGQGTKGFCGTLEYCAPELFSGKEYDAKAVDIWSMGVVLYIMVTASFPFKANTYSEMKEEMLDPKYHLPSTLCKNIANIIVQLFTLKPEQRPKIVDIRQQQWLKTKQEFGKITPSLEALWNNLNPSIVVPMGRMGYHPKDITACLREKKFNNIMATYLILNHKSPCDQYKYAAKFLPGRDPMSPADALTSFPTQRGLSELALSILLEEHQVHDDNGSRKKRMRSLSMPASLCCQQKGNKHPPPAPKIAPKHTYLKSRCLALDSMICKSSSSRSVSSESSSSASFCSCETPQEVNTPNNGSDTQRSGSYREVPHIVNTTATYDIQRGSLQTTSKDSFGDVPPEGIPEIQTYSLQATSKESFEDVPPEGKAEMRRSSGWENSKNSFEDVPSEATTEIQISSIQETSKNSFHDQSSRKSFDNVLLEGIPEIQSCNSLEDVLSKDLCEIPRPFLQETSNNIFEDVPPEEIPEIRKPSLPVTSKTSCEDAPPRGVTAASESRLSRGWKRVKKTIGHCLRRLCCCVPASRRSQGSQKKVEPVEVGSSAVPHMQLRGVPKMHSCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JTT1</accession>
    <name>A0A9J7JTT1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC113834342</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC113834342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035294614.1">
        <property type="nucleotide sequence ID" value="XM_035438723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JTT1"/>
    <dbReference type="GeneID" id="113834342"/>
    <dbReference type="KEGG" id="cge:113834342"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035294614.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="29961" checksum="5A24A54D40DB3965" modified="2023-06-28" version="1">MKVKNNSSGRWAVPKLQTKGDGSPCSTGQQKLQPQEPHSGGWAVRLRGVSLVGGTYPEEFARGGSGRDSGKEKVEARARARIPGAGGAPAPRPRPATHGAESPKLLSLFLRVALRGREGRVEYRRFAHRLGQRLPRAPGVGPREARGRQQGHERLRGTGALVAAATAQHGSPGRPVPAALAAHRKRPARVIACDPRASATDRSSVGTDWRLGGWMGAGDPLKRTDSFRPNFPEPEASAEVAKQGAQPAQGRNLGQSGNRGGALPSSASPFRTFWLLQVEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JWD0</accession>
    <name>A0A9J7JWD0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Prostaglandin E synthase</fullName>
            <ecNumber evidence="7">2.5.1.18</ecNumber>
            <ecNumber evidence="6">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Glutathione peroxidase PTGES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Glutathione transferase PTGES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Microsomal prostaglandin E synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">Ptges</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
            <tissue evidence="32">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="29">Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:48620"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57450"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:90632"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:53324"/>
            <dbReference type="ChEBI" id="CHEBI:85166"/>
            <dbReference type="ChEBI" id="CHEBI:137172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:53325"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:64364"/>
            <dbReference type="ChEBI" id="CHEBI:82629"/>
            <dbReference type="ChEBI" id="CHEBI:152564"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:64365"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MAPEG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="7"/>
    <dbReference type="EC" id="5.3.99.3" evidence="6"/>
    <dbReference type="RefSeq" id="XP_007652387.1">
        <property type="nucleotide sequence ID" value="XM_007654197.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279020.1">
        <property type="nucleotide sequence ID" value="XM_027423219.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JWD0"/>
    <dbReference type="GeneID" id="100770965"/>
    <dbReference type="KEGG" id="cge:100770965"/>
    <dbReference type="CTD" id="9536"/>
    <dbReference type="OrthoDB" id="193139at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF9">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 30" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00039926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00041613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00042011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00042173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00054772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027279020.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26728" checksum="1E8ADCD2BA3CA6EE" modified="2023-06-28" version="1">MGEVITDELRRGTWEHGPSLFGLLIWTEDHLLSRSPPGLQHKPQGWNFFSSSWSTQSMLCSLWDSLTLSHRVRSWISGHLAKTPSMGLVMENGQVLPAFLLCSTLLVIKMYVVGVITGYTRLRKKAFANPEDALRHGGLQYYRSDPNVERCLRAHRNDMETIYPFLFLGFVYSFLGPEPLIAWIHFLVVLTSRVVHTVAYLGKMNPRVRSGAYVLAQFACVSMALQILWEVAHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JXG8</accession>
    <name>A0A9J7JXG8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pentraxin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ptx4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003501528.1">
        <property type="nucleotide sequence ID" value="XM_003501480.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280832.1">
        <property type="nucleotide sequence ID" value="XM_027425031.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JXG8"/>
    <dbReference type="GeneID" id="100774180"/>
    <dbReference type="KEGG" id="cge:100774180"/>
    <dbReference type="CTD" id="390667"/>
    <dbReference type="OrthoDB" id="8793160at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF122">
        <property type="entry name" value="PENTRAXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039916886" evidence="8">
        <location>
            <begin position="23"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="9">
        <location>
            <begin position="269"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027280832.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53169" checksum="D85F3220DCBCC058" modified="2023-06-28" version="1">MDCLKKKTLSFLLIFVSIYARGTLLQEAGPARQRKPFFERLRRLEEQFQRFQQVTLTHLQDIASNYNVYYNVDARFQSLVEESQAIALAANRSQVAIQKDVAHLKTWLRKIQRRSQKVDAQLQALNLSLSTKSRQWVEEEKEQKAKREVTASLALSIRALQDALASLTQQVHSQDARLAALEGQIQRASPGTAVLGLTTAPMPTQLAQRGPGSLQLWRNSQTSRPSLQNRSSPQDFTVHVQKTQKFQAPSRHQAALPRTHQEPGNICSSGPVLIFPNASTENVIFLSPSFLTPLRALSFCSWIRMASGHLGTLLSYATKDNDNKLVLHGRDSLDPGSIHFVIGDPVFRELSLKPLLDGQWHHICIIWTSMEGKYWLHIDRRIVATGTHFREGYEIPPGGSLVLGQEQDTMGGEFDSSEAFVGSISGLAIWDRALVPKEVANLATGKELPTGAILTLTNATSVGGFVKRAKCTCLEQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JZH4</accession>
    <name>A0A9J7JZH4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Regulator of G-protein signaling 19 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9 10 11" type="primary">Rgs19</name>
    </gene>
    <organism evidence="4 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5 6 7">17A/GY</strain>
            <tissue evidence="5 6 7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003512402.1">
        <property type="nucleotide sequence ID" value="XM_003512354.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651039.1">
        <property type="nucleotide sequence ID" value="XM_007652849.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651040.1">
        <property type="nucleotide sequence ID" value="XM_007652850.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651042.1">
        <property type="nucleotide sequence ID" value="XM_007652852.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016836096.1">
        <property type="nucleotide sequence ID" value="XM_016980607.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016836098.1">
        <property type="nucleotide sequence ID" value="XM_016980609.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275818.1">
        <property type="nucleotide sequence ID" value="XM_027420017.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275819.1">
        <property type="nucleotide sequence ID" value="XM_027420018.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275820.1">
        <property type="nucleotide sequence ID" value="XM_027420019.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275822.1">
        <property type="nucleotide sequence ID" value="XM_027420021.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275823.1">
        <property type="nucleotide sequence ID" value="XM_027420022.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275830.1">
        <property type="nucleotide sequence ID" value="XM_027420029.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292713.1">
        <property type="nucleotide sequence ID" value="XM_035436822.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302241.1">
        <property type="nucleotide sequence ID" value="XM_035446350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JZH4"/>
    <dbReference type="GeneID" id="100766929"/>
    <dbReference type="KEGG" id="cge:100766929"/>
    <dbReference type="CTD" id="10287"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.196.10:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF145">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="90"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027275818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027275819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027275820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027275822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027275823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027275830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035302241.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24680" checksum="AD42802A983C6B17" modified="2023-06-28" version="1">MPTPHEAEKQHTGPEEADRPPSMSSHDAAPSGPPSRNPCCLCWCCCCSCSWNQERQRAWQASRESKLQPLPSCEACTPPSPEEVQSWAQSFDKLMHSPTGRSVFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINRKMQEPSPHTFDDAQLQIYTLMHRDSYPRFLTSPAYRSLLLQGAPQSSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K6T5</accession>
    <name>A0A9J7K6T5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Protein PRRC2B isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">Prrc2b</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5 6 7">17A/GY</strain>
            <tissue evidence="5 6 7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027279646.1">
        <property type="nucleotide sequence ID" value="XM_027423845.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279647.1">
        <property type="nucleotide sequence ID" value="XM_027423846.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302134.1">
        <property type="nucleotide sequence ID" value="XM_035446243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755319"/>
    <dbReference type="KEGG" id="cge:100755319"/>
    <dbReference type="CTD" id="84726"/>
    <dbReference type="OrthoDB" id="1939715at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009738">
        <property type="entry name" value="BAT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033184">
        <property type="entry name" value="PRRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038">
        <property type="entry name" value="BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038:SF4">
        <property type="entry name" value="PROTEIN PRRC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07001">
        <property type="entry name" value="BAT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAT2 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1590"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1648"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1873"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2105"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2151"/>
            <end position="2240"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
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        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
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        <location>
            <begin position="1034"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1194"/>
        </location>
    </feature>
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        <location>
            <begin position="1243"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1665"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1696"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1723"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1758"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1877"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2105"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2153"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2171"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2214"/>
            <end position="2223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027279646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027279647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035302134.1"/>
        </source>
    </evidence>
    <sequence length="2240" mass="244482" checksum="FF0BD99BEBCA320D" modified="2023-06-28" version="1">MSDRLGQITQGKDGKSKYSTLSLFDKYKGRSVGAVRSSVIPRHGLQSLGKVATARRMPPPANLPSLKSENKGNDPNIVIVPKDGTGWANKQDQQDPKSSSVTASQPPESQPQPGLQKSVSNLQKPTQSISQENTNSVPGGPKSWAQLSGKPVGHEGGLRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKGALDLSYGPGPSLRPQNVTSWREGGGRNIISTTSLNASPTELGSRNSSAGDGAPSSACASESKDPSLRPAQPIRKGASQFMGHTYQPPTYHDMLPAFMCSPQSSENQGMVERSSFPLPQLRLEPRVPFRQFQMNDQEGKERPVLARPVRPLRQLVERAPRPTIINAENLKGLDDLDTDADDGWAGLHEEVDYSEKLKFSDDEEEEEAVKDGRSKWNTWDPRRQRELSLSSADSADAKRTQEEGKDWGEAASVSRGVRKVPEPPPPSRKLHSWPAGPDYQKPSMGSIFRQHSVEDKEDKPPPRQKFIQSEMSEAVERARKRREEEERRAREERLAACAAKLKQLDQKCKQAQKASEAPKPVEKEVPRSPGIEKVSPQENGPVVRKGSPEFPVQEAPTMFLEETPAASPAVAQSSSSSSSSAGEEEVREAGSPAQEFSKYQKSLPPRFQRQQQQQQQQQQQQQQQQQQQQQQEQLYKMQHWQPVYPPPSHPQRTFYPHHPQMLGFDPRWMMMPSYMDPRITPTRTPVDFYPSALHPSGLMKPMMPQESLSGTGCHSEDQNCVPSLQERKVTTIDPAPVWSPEGYMALQSKGYSLAHPKSADTLAMDMHVRNERSYSASPGRSGGISAQRDLFEERGEEYLSAFDKKAQADFDSCISSQRIGQELLFPPQENVQEVGAPGGRTPNLRCSPLEPDFVPAEKKPEYGSWDVGHQPKAADTANSVELEAPREEPSFHVPSWEKEGSPKKQPNPEPDWTPEPRSQHQEHPGRTRRSGPIKKPVLKALKIEEKEKALERVRQGLGEESSQLAVDKEPMCRAEEDEDEENNPALANASSSALEDKAAVRPGFGHEANKLDEDAKSDKTWESRPSREASDIPPTKRNNWIFIDEEQAFGGRGQARSRGRGFREFTFRGSRPAGSNTSGLGGAGVLGARSMYSSGHRSSRGRGLRDFPLPEDCPRAKPRRRIASETHSEGSEYEELPKRRRQRGSEPGHEGMLLERDEGALKKDSWRSNRTYTEDQGGPDARSRGARPCGRALPPRLSNCSYGRRSFVAKEPPHWQSRSPGSSWQEYGPSDPCGPRRATDRDYIPESYRHTDTFGSRVFEDSRMEDKRSFFQDDHGADSENAENRPFRRRRPPRQDKPPRFRRLRQERESLGLWGPEEESHLLASQWPGRSKLCPGDKNGPGDHRSPELSYQNSSDHANEEWETASESSDFSERRERREGLTAEPEAQGDGGLSGASLGEKKELAKRSFSSQRPLADRQSRKLEPGGFGEKPVRPGGGETSPRCESQQSGTPLKVKRSPDEALPGGLGCSNGSHSSYALERTPHASSDSPETASKKAEKEAALAAQRAGEQQEEARKQFDLGYGNAIIDNCGSSPGEESEVGAMGGEGFIEVLTKKQRRLLEEERRKKEQAAQVPVKGRGLSSRIPPRFAKKQNSLCLEQGDMAVPGSSLGTEIWESGSQALPVQGAASDSWRKAVTAFSSTEPGTSEQGFKSSQGDSGVDLSAESRESSATSSQRSSPYGTLKPEEMSGPGLVEPKADSHKDQKQSEHKDPDQSPGQSKEHRPGPIGNERSLKNRKGSEGGERLQGAGVPPVNGVEIHVDSVLPVPPIEFGVNPKDSDFSLPPGSASGPVGNPVAKLQDVLASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLTLKMESARKAWENSPSLPEQSSPGGAGSGIQPPSSVGASNGVNYSSFGGVSMPPMPVASVAPSASMPGNHLPPLYLDGHVFASQPRLVPQTIPQQQSYQQAATAQQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMILSGGTALKPPYSAFPGIQPLEMVKPQSGSPYQPMSGSQALVYEGQLGQAAGLGTSQMLDSQLPQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRIPPPGSQPPVLNTSRESAQMELKGFHFADSKQNVPTGGSAPSPQAYRPSSASPSGKPSGSAVNMGSVQGHYVQQAKRMDEKPSLGTVKLQEASSATSQMKRTGAIKPRAVKVEESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KBI6</accession>
    <name>A0A9J7KBI6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Otoferlin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Fer-1-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">Otof</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="21">Interacts with SNAP25; the interaction is direct. Interacts with STX1; the interaction is direct. Interacts with RAB8B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Basolateral cell membrane</location>
            <topology evidence="18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cytoplasmic vesicle</location>
            <location evidence="19">Secretory vesicle</location>
            <location evidence="19">Synaptic vesicle membrane</location>
            <topology evidence="19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Presynaptic cell membrane</location>
            <topology evidence="20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferlin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303518.1">
        <property type="nucleotide sequence ID" value="XM_035447627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759573"/>
    <dbReference type="KEGG" id="cge:100759573"/>
    <dbReference type="CTD" id="9381"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08373">
        <property type="entry name" value="C2A_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000009">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000081">
        <property type="entry name" value="otoferlin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000089">
        <property type="entry name" value="otoferlin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000034">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000054">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037726">
        <property type="entry name" value="C2A_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF32">
        <property type="entry name" value="OTOFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1925"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="26">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="26">
        <location>
            <begin position="216"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="26">
        <location>
            <begin position="380"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="26">
        <location>
            <begin position="924"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="26">
        <location>
            <begin position="1096"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="26">
        <location>
            <begin position="1437"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="26">
        <location>
            <begin position="1675"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="622"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1259"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1309"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="1275"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="1313"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1331"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00067393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_035303518.1"/>
        </source>
    </evidence>
    <sequence length="1958" mass="222349" checksum="6B0FB7F3CE27069F" modified="2023-06-28" version="1">MSGSGQGQSFYSRVLENCEDVADFDETFRWPVASNIDRNEILEIQIFNYSKVFSNKLIGTFRMVLQKVVEENRVEVTDTLIDDNNAIIKTSLNMEVRYQAADSTMGSWDDGDFLGDEALQEEEKDSQETDGLLPGSRPSTRTPGEKSFRRAGRSVFSAMKLGKTRSHKEEPQRQDEPAVLEMEDLDHLAIRLGNGMDPDSVSLASVTALTSNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTGRMEEFFLFGAFLEASMIDRKNGDKPITFEVTIGNYGNEVDGMSRPQRPRPRKEPGDEEEVDLIQNSSDDEGDEGGDLASVSSTPPMRPQITDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMIKTEKSYPERRLRGVLEELSCGCHRFLSLSDKDQGHSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDVFIWMMSNNKRVAYARVPSKDLLFSIVEEELGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKLELYLWLGLSKQRKDFLSGLPCGFEEVKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDTMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPSGKADLPPINGPVDMDRGPIMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRTAPNWNTTGEVVVSMEPEVPVKKLETMVKLDATSDAVVKVDVAEEEKERKKKKKKGTSDEAEEEEPDESTLDWWSKYFSSIDTMKEQLRQHEASGIDLEEKEEMDTTEGLKGPIKNKDKSRAAKEEKKKKNPGSGPGQGPEAPEKKKAKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPDDVSREAGYDPTYGMFQGIPSNDPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRASCGIAQTYSIHGYNIWRDPMKPSQILTRLCKEGKVDGPHFGPHGRVKVANRVFTGPSEIEDENGQKKPTDEHVALSALRHWEDIPRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLALFLYSLPGYMVKKLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KEC4</accession>
    <name>A0A9J7KEC4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: speckle-type POZ protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113832658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035307210.1">
        <property type="nucleotide sequence ID" value="XM_035451319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113832658"/>
    <dbReference type="KEGG" id="cge:113832658"/>
    <dbReference type="OrthoDB" id="9620671at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="143"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035307210.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33737" checksum="F7E3BF558AC06476" modified="2023-06-28" version="1">MWESPLKKWKKESHLRQATCMLDQVRQQQVPNTQGQPSLHLPAQVVQELFPATVRHSCSESSDTSDLRARRSSAAGSHTPRPDFLLDHGQWLLPESELTVFCKVTVFQDSFSISDRIRKPXYKVTRCRMADELREQWENSPFTDCCLVVSGQEFLVYNGILAAQSPVFRAMFEHDMKERRTNQVEINDLEPQGFKGMMDFIYTGKVPDLQSIADAILTAADKYGLEHLKVMCEDALCRDLSVEIAAHTLFLADFHNAGLLKTRALDFITAHFSEVSETSSWKAMVASYPHLVVEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3GTN1</accession>
    <name>G3GTN1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mago homolog, exon junction complex core component</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Protein mago nashi homolog</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Protein mago nashi-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Magoh</name>
        <name evidence="8" type="ORF">I79_001016</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000020">
        <property type="protein sequence ID" value="EGV91744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003495778.1">
        <property type="nucleotide sequence ID" value="XM_003495730.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258202.1">
        <property type="nucleotide sequence ID" value="XM_027402401.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GTN1"/>
    <dbReference type="SMR" id="G3GTN1"/>
    <dbReference type="STRING" id="10029.G3GTN1"/>
    <dbReference type="PaxDb" id="10029-XP_007611062.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025884.1">
        <property type="protein sequence ID" value="ENSCGRP00001021640.1"/>
        <property type="gene ID" value="ENSCGRG00001020438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766467"/>
    <dbReference type="KEGG" id="cge:100766467"/>
    <dbReference type="CTD" id="4116"/>
    <dbReference type="eggNOG" id="KOG3392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003156"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="9547621at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990501">
        <property type="term" value="C:exon-exon junction subcomplex mago-y14"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000622">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF2">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV91744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027258202.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17164" checksum="FFAD0B075E045875" modified="2011-11-16" version="1">MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G3H300</accession>
    <name>G3H300_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylinositol 4-kinase beta</fullName>
            <ecNumber evidence="5">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Pi4kb</name>
        <name evidence="23" type="ORF">I79_004605</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. May play an important role in the inner ear development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19878"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6. Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding. Interacts with ACBD3. Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN. Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane. Interacts with ATG9A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Rough endoplasmic reticulum membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="5"/>
    <dbReference type="EMBL" id="JH000120">
        <property type="protein sequence ID" value="EGV94837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498718.1">
        <property type="nucleotide sequence ID" value="XM_003498670.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249363.1">
        <property type="nucleotide sequence ID" value="XM_027393562.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H300"/>
    <dbReference type="STRING" id="10029.G3H300"/>
    <dbReference type="PaxDb" id="10029-XP_007624140.1"/>
    <dbReference type="GeneID" id="100770133"/>
    <dbReference type="CTD" id="5298"/>
    <dbReference type="eggNOG" id="KOG0903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H300"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22246">
        <property type="entry name" value="PI4KB_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000031">
        <property type="entry name" value="Phosphatidylinositol 4-kinase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000004">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="22">
        <location>
            <begin position="52"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="21">
        <location>
            <begin position="520"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="248"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV94837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027249363.1"/>
        </source>
    </evidence>
    <sequence length="801" mass="89870" checksum="ABE391BA147E6923" modified="2011-11-16" version="1">MGDMVVEPATLKPTSDPTASPSGNNGGTLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGATVAPGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3H4L3</accession>
    <name>G3H4L3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leucine rich repeat containing 3B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12 16">Leucine-rich repeat-containing protein 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Lrrc3b</name>
        <name evidence="12" type="ORF">I79_005218</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the LRRC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000141">
        <property type="protein sequence ID" value="EGV92263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307679.1">
        <property type="nucleotide sequence ID" value="XM_035451788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308294.1">
        <property type="nucleotide sequence ID" value="XM_035452403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H4L3"/>
    <dbReference type="STRING" id="10029.G3H4L3"/>
    <dbReference type="PaxDb" id="10029-XP_007626220.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012076.1">
        <property type="protein sequence ID" value="ENSCGRP00001007983.1"/>
        <property type="gene ID" value="ENSCGRG00001010343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769466"/>
    <dbReference type="KEGG" id="cge:100769466"/>
    <dbReference type="CTD" id="116135"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157780"/>
    <dbReference type="OMA" id="PKGCACQ"/>
    <dbReference type="OrthoDB" id="10068119at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000069">
        <property type="entry name" value="leucine-rich repeat-containing protein 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732093" evidence="10">
        <location>
            <begin position="33"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="11">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV92263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035308294.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29247" checksum="21BEF3D77A9A9914" modified="2011-11-16" version="1">MNLVDLWLSRSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAANDADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKKADEPDDVSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3HCF1</accession>
    <name>G3HCF1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">Yju2</name>
        <name evidence="8" type="synonym">YJU2</name>
        <name evidence="12" type="ORF">H671_5g15157</name>
        <name evidence="11" type="ORF">I79_008161</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000282">
        <property type="protein sequence ID" value="EGV93688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE680550">
        <property type="protein sequence ID" value="ERE72222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272702.1">
        <property type="nucleotide sequence ID" value="XM_027416901.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311308.1">
        <property type="nucleotide sequence ID" value="XM_035455417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HCF1"/>
    <dbReference type="STRING" id="10029.G3HCF1"/>
    <dbReference type="PaxDb" id="10029-XP_007616171.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001004636.1">
        <property type="protein sequence ID" value="ENSCGRP00001003246.1"/>
        <property type="gene ID" value="ENSCGRG00001003899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755173"/>
    <dbReference type="KEGG" id="cge:100755173"/>
    <dbReference type="CTD" id="55702"/>
    <dbReference type="eggNOG" id="KOG2989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENCDYQN"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV93688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ERE72222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027272702.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35943" checksum="68E9A6A26F46C9AF" modified="2011-11-16" version="1">MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLLQHRLSQEQRRQQQEEEDERETAALLEEARHRRLLEDSDSEDEAPPSRPRAAARPNPTAILDEAPKTKRKAEAVGSRAQLAGLVVPKKVKMEANGGSEQVWMHSSGAPESRKATSLAPQKPGASSLSQLGAYGDSEDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G3HFA8</accession>
    <name>G3HFA8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">AP-3 complex subunit delta-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">AP-3 complex subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Adaptor-related protein complex 3 subunit delta-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Delta-adaptin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Ap3d1</name>
        <name evidence="20" type="ORF">I79_009264</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000325">
        <property type="protein sequence ID" value="EGV99532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502629.1">
        <property type="nucleotide sequence ID" value="XM_003502581.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275118.1">
        <property type="nucleotide sequence ID" value="XM_027419317.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HFA8"/>
    <dbReference type="STRING" id="10029.G3HFA8"/>
    <dbReference type="PaxDb" id="10029-XP_007614914.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027756.1">
        <property type="protein sequence ID" value="ENSCGRP00001023510.1"/>
        <property type="gene ID" value="ENSCGRG00001021701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770344"/>
    <dbReference type="KEGG" id="cge:100770344"/>
    <dbReference type="CTD" id="8943"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICITNIG"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5 6 7">17A/GY</strain>
            <tissue evidence="5 6 7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000457">
        <property type="protein sequence ID" value="EGW12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007644669.4"/>
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        <property type="nucleotide sequence ID" value="XM_016976499.3"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027437793.2"/>
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    <dbReference type="KEGG" id="cge:100754804"/>
    <dbReference type="eggNOG" id="ENOG502S81N">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="entry name" value="DUF4534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34928">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34928:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15049">
        <property type="entry name" value="DUF4534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027250226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027250227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027250228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027250229.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21669" checksum="DE13B4D371C13CA9" modified="2011-11-16" version="1">MKQQNWFGLTAKMGTVLSGVFSIMATHMHLIFERKHLENSNCTDNLQSQFTNVVSHFIICWSFKIVLLLSLVTMAVSCFLLYSVYAQIYGGLMSYTIWIFTYESINLAVQIFTNEFSVALVRAMRWFGWVSRASLHSLCLYFVVTHAQIIYQSKKQGNIISYHRRISLGAGDAPRRKSKIITFIHHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3HLE6</accession>
    <name>G3HLE6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8 11">Homeobox protein PKNOX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Pknox1</name>
        <name evidence="8" type="ORF">I79_011534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000489">
        <property type="protein sequence ID" value="EGW02918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643191.1">
        <property type="nucleotide sequence ID" value="XM_007645001.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306643.1">
        <property type="nucleotide sequence ID" value="XM_035450752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HLE6"/>
    <dbReference type="STRING" id="10029.G3HLE6"/>
    <dbReference type="PaxDb" id="10029-XP_007628407.1"/>
    <dbReference type="GeneID" id="100761855"/>
    <dbReference type="CTD" id="5316"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HLE6"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000004">
        <property type="entry name" value="Meis2 homeobox isoform 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="258"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW02918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035306643.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="47402" checksum="6BD76D3C47EB06FD" modified="2011-11-16" version="1">MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSDPDAEGVSPPPIESQTPMDADKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKDGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQIQSAITGTLSPQGIVVPASALQQGNVTMATVAGGTVYQPVTVVTPQGQVVTQALSPGTIRIQNSQLQLQLNQDLSILHQEDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKPAQNRPVQRFWPDSLASGVAQATSSELAMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEDDGGTLGPTHISGLVLENSDSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3HP24</accession>
    <name>G3HP24_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25 26 27" type="primary">Iars1</name>
        <name evidence="21" type="ORF">I79_012527</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25 26 27" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25 26 27">17A/GY</strain>
            <tissue evidence="25 26 27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="JH000564">
        <property type="protein sequence ID" value="EGV99798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505383.1">
        <property type="nucleotide sequence ID" value="XM_003505335.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007644042.2">
        <property type="nucleotide sequence ID" value="XM_007645852.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007644043.1">
        <property type="nucleotide sequence ID" value="XM_007645853.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265726.1">
        <property type="nucleotide sequence ID" value="XM_027409925.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265727.1">
        <property type="nucleotide sequence ID" value="XM_027409926.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265728.1">
        <property type="nucleotide sequence ID" value="XM_027409927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HP24"/>
    <dbReference type="SMR" id="G3HP24"/>
    <dbReference type="STRING" id="10029.G3HP24"/>
    <dbReference type="PaxDb" id="10029-XP_007617411.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031046.1">
        <property type="protein sequence ID" value="ENSCGRP00001026800.1"/>
        <property type="gene ID" value="ENSCGRG00001023981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754316"/>
    <dbReference type="KEGG" id="cge:100754316"/>
    <dbReference type="CTD" id="3376"/>
    <dbReference type="eggNOG" id="KOG0434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074921"/>
    <dbReference type="OMA" id="EIIVIHK"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000056">
        <property type="entry name" value="Isoleucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000414">
        <property type="entry name" value="Isoleucine--tRNA ligase, cytoplasmic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057033">
        <property type="entry name" value="Ubiquitin_IARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23567">
        <property type="entry name" value="Ubiquitin_IARS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17 21" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17 25" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="18">
        <location>
            <begin position="18"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="19">
        <location>
            <begin position="693"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Isoleucine--tRNA ligase cytoplasmic ubiquitin-like" evidence="20">
        <location>
            <begin position="1077"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="Isoleucine--tRNA ligase cytoplasmic ubiquitin-like" evidence="20">
        <location>
            <begin position="1169"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV99798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027265726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027265727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027265728.1"/>
        </source>
    </evidence>
    <sequence length="1262" mass="144046" checksum="E75335766256B86B" modified="2011-11-16" version="1">MVQQVPENISFPAEEEKTLQFWSKYNCFQECLKQSKNRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQCRAIVMRYSTEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSSACGTPLSNFESNQNYKDVQDPSVFVTFPLEEDENTSLVAWTTTPWTLPSNLALCVNPEIQYVKIKDVARGKLFILMEARLSALYKLESDYEILERFPGASLKGKKYKPLFDYFIKCKENGAFTVLVDHYVKDEEGTGVVHQAPYFGADDHRVCMDFNIIQKDSTPVCPVDASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLLVASTFTHSYPFCWRSDTPLIYKSVPSWFVRVEHMVDQLLKNNDLCYWVPEFVREKRFGNWLKEARDWAISRNRYWGTPIPLWVSEDFEEVVCIGSVAELEELSGTKISDLHRESIDHLTIPSRCGKGLLRRVSEVFDCWFESGSMPYAQVHYPFESKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIINKYGSDALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFFVQNVFRLHKEDGVEFLYNEHTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGESGTEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKTLIDPASVRDKDTLSIHYLMLPRVREELIDKKTEDAVSRMQSVIELGRVIRDRKTVPIKYPLKEIVVIHQDPEALEDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMMAIKQLSSEELEQFQKSGSIVVEGHELHEEDIRLMYSFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYNAKSEGRYLNNVIESHTDFIFATVKAPLKAYPVPTSDNILIQEQTQLKGSELELTLTRGSCVPGPACAYVNLNICANGIEQGGVLLLENPKGDNKLNLVKLKSVVTSIFGVKNAELSVFHGETEIQSQTDLLSLSGRTLCVTAGAAPSAVNSPSALLCQYINLQLLNAGPQECLTGTVGTLLLENPLGQNGLSHQGLVYEAAKVFGLRSRRLKLFLNKTQTEEITEDIPMKTLNMKTVYVSVLPTTADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3HST8</accession>
    <name>G3HST8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">p21-activated protein kinase-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAK1-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">Pak1ip1</name>
        <name evidence="14" type="ORF">H671_3g9564</name>
        <name evidence="13" type="ORF">I79_013933</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
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        </source>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <text evidence="7">Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.</text>
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                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
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                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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                <person name="Borth N."/>
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    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000676">
        <property type="protein sequence ID" value="EGV92096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288216.1">
        <property type="nucleotide sequence ID" value="XM_027432415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HSW9"/>
    <dbReference type="STRING" id="10029.G3HSW9"/>
    <dbReference type="PaxDb" id="10029-XP_007626315.1"/>
    <dbReference type="GeneID" id="100751753"/>
    <dbReference type="CTD" id="3421"/>
    <dbReference type="eggNOG" id="KOG0784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HSW9"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000011">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF78">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 15" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV92096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027288216.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="36741" checksum="BF4BE7C6FFBC612F" modified="2011-11-16" version="1">MIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKNIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFDSMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSQAIQDIIRHIRIINGRAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3HVR3</accession>
    <name>G3HVR3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">PR domain zinc finger protein 1</fullName>
            <ecNumber evidence="21">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27 30" type="primary">Prdm1</name>
        <name evidence="26" type="ORF">I79_015054</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="27" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11. Interacts with multiple nuclear sumoylation E3 ligases, including CBX4, PIAS1, PIAS2, PIAS3, PIAS4, PML and RNF4, but not RANBP2. Interacts with LDB1, SMARCD3 and SMARCC1. Interacts with EEIG1; following TNFSF11/RANKL stimulation in bone marrow-derived macrophages, the interaction promotes the binding of PRDM1/BLIMP1 to the gene promoter of IRF8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the class V-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="21"/>
    <dbReference type="EMBL" id="JH000792">
        <property type="protein sequence ID" value="EGW00265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003507429.1">
        <property type="nucleotide sequence ID" value="XM_003507381.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257699.1">
        <property type="nucleotide sequence ID" value="XM_027401898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HVR3"/>
    <dbReference type="STRING" id="10029.G3HVR3"/>
    <dbReference type="GlyGen" id="G3HVR3">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007624556.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030050.1">
        <property type="protein sequence ID" value="ENSCGRP00001025804.1"/>
        <property type="gene ID" value="ENSCGRG00001023291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759446"/>
    <dbReference type="KEGG" id="cge:100759446"/>
    <dbReference type="CTD" id="639"/>
    <dbReference type="eggNOG" id="KOG2461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154798"/>
    <dbReference type="OMA" id="LIMKMDM"/>
    <dbReference type="OrthoDB" id="9345291at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033082">
        <property type="term" value="P:regulation of extrathymic T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032823">
        <property type="term" value="P:regulation of natural killer cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051136">
        <property type="term" value="P:regulation of NK T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19187">
        <property type="entry name" value="PR-SET_PRDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000748">
        <property type="entry name" value="PR domain zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000019">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000132">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000211">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000262">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016608">
        <property type="entry name" value="PRDM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044413">
        <property type="entry name" value="PRDM1_PR-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF59">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013212">
        <property type="entry name" value="PRDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="25">
        <location>
            <begin position="84"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="324"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGW00265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027257699.1"/>
        </source>
    </evidence>
    <sequence length="825" mass="91850" checksum="2A38CD9AFA2865E0" modified="2011-11-16" version="1">MLDLLLEKRVGTTLAAPKSSSSSVKFQGLVDTRGIMKMDMEDADMTLWTEAEFEEKCTYIVNDYSWDSSAADGGTCVQAEASLPRNLLFKYATNNSKEVIGVVSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMVTPTQTESYPKQYSSGKNELYPKTVPKREYSVKEILKLDSNPSKRKDFYCPDISSLTSEKDMDGFRKNGSPDMPFYPRVVYPIRAPLPEDFLKASLAYGLERPTYITNSPLPSSTTPSPPASSSPEQSLKSSSPQSSPGNTVSPLAPGPLEPRDSYSYLNASYGSEGLGSYPGYAPAPHLPPAFIPSYNAHYPKFLLPPYGISSNGLSTMNNINGINNFSLFPRLYPVYSNLLSGGNLPHPMLSPASLPSSLPSDGARRLLPPEHPREVLVPAPHSAFSLTGTAASMKDESSPPSGSPTAGTAATSEHVVQPKATSAVMAAPSTDGAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCAQCHKSYIHLSSLKVHLKGNCPVAPAAGLPLEDLTRINDEIEKFDISDNADRLEDMEDNMDVTSMVEKEILAVVRKEKEETGLKVSLQRNLGNGLLSSGCGLYESSDLPLMKLPHSNPLPLVPVKVKQETVEPMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3I4W1</accession>
    <name>G3I4W1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Actin-associated protein FAM107A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Fam107a</name>
        <name evidence="21" type="ORF">I79_018500</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH001270">
        <property type="protein sequence ID" value="EGW11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510276.2">
        <property type="nucleotide sequence ID" value="XM_003510228.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244261.1">
        <property type="nucleotide sequence ID" value="XM_027388460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I4W1"/>
    <dbReference type="STRING" id="10029.G3I4W1"/>
    <dbReference type="PaxDb" id="10029-XP_007636745.1"/>
    <dbReference type="GeneID" id="100763708"/>
    <dbReference type="KEGG" id="cge:100763708"/>
    <dbReference type="CTD" id="11170"/>
    <dbReference type="eggNOG" id="ENOG502RZJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I4W1"/>
    <dbReference type="OrthoDB" id="5963205at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009533">
        <property type="entry name" value="FAM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768:SF3">
        <property type="entry name" value="ACTIN-ASSOCIATED PROTEIN FAM107A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768">
        <property type="entry name" value="DOWN REGULATED IN RENAL CARCINOMA 1/TU3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06625">
        <property type="entry name" value="DUF1151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGW11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027244261.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20026" checksum="E2C36A3AE315FD9B" modified="2011-11-16" version="1">MAQKLGEWGKAPAEATGLYRAMLLRSASMYSEIQRERADIGGLMARPEYKEWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKEEELEAKRLQCPFKQELLRRQQRLNQLENPPQREEAHAPEFIKVRENLRRIATEERAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3I5D2</accession>
    <name>G3I5D2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 subunit C2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Ndufc2</name>
        <name evidence="13" type="ORF">I79_018676</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFC2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001295">
        <property type="protein sequence ID" value="EGW00449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510438.1">
        <property type="nucleotide sequence ID" value="XM_003510390.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263482.1">
        <property type="nucleotide sequence ID" value="XM_027407681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I5D2"/>
    <dbReference type="STRING" id="10029.G3I5D2"/>
    <dbReference type="PaxDb" id="10029-XP_007612825.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021184.1">
        <property type="protein sequence ID" value="ENSCGRP00001016940.1"/>
        <property type="gene ID" value="ENSCGRG00001017125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766442"/>
    <dbReference type="KEGG" id="cge:100766442"/>
    <dbReference type="CTD" id="4718"/>
    <dbReference type="eggNOG" id="KOG4516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010352"/>
    <dbReference type="OMA" id="WFIGYHI"/>
    <dbReference type="OrthoDB" id="6329847at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009423">
        <property type="entry name" value="NDUC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13099:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13099">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06374">
        <property type="entry name" value="NDUF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017834">
        <property type="entry name" value="NADH-UbQ_OxRdtase_b14.5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW00449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027263482.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14136" checksum="02DEAE4434475768" modified="2011-11-16" version="1">MMSGRPGREPFKFLPDESRGLPPPKLNDPRLVYTGFLGYCAGLLNNALKGRPVLKAGLHRQLLYVTSFYFVGYFFLKRQEYWYAVRDHDMFGYMKLHPEDFPEKEKKTYGEILEVFHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3IGM0</accession>
    <name>G3IGM0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4 7">Speckle-type POZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100774822</name>
        <name evidence="4" type="ORF">I79_022938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002595">
        <property type="protein sequence ID" value="EGW04286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513907.1">
        <property type="nucleotide sequence ID" value="XM_003513859.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245818.1">
        <property type="nucleotide sequence ID" value="XM_027390017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IGM0"/>
    <dbReference type="STRING" id="10029.G3IGM0"/>
    <dbReference type="PaxDb" id="10029-XP_007607683.1"/>
    <dbReference type="GeneID" id="100774822"/>
    <dbReference type="KEGG" id="cge:100774822"/>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3IGM0"/>
    <dbReference type="OrthoDB" id="9620072at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000003">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="189"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGW04286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027245818.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34845" checksum="8E35EF99B5578706" modified="2011-11-16" version="1">MTEDRAAERWGYTEISVQKFSYIWTIRKFRFLLQERGDAIKSPTFSSGASDNDKWCLEILTNGFDEESKDYLSILLTLLSCPKSPVWARFQFSIMSVDGEKTKGMISPRFFKSTPNQQCGFKKFIHRDLFLSLESWLLPDNELTVLCDVDLAIQDSFINSEESTVPGIQGPRCTTADELGQLWENSLFTDCSLVVAGQEFGAHKAILAARSPVFRAMFEHDMEERRKNCAEIHDLEPQVFKAMMDFIYTGKVTVFHSMADSIPAAADKYGLERLKVMCEDPHLLAEAFSTWHLLTPLYWNPFPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3IHI1</accession>
    <name>G3IHI1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Integrin beta-1-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 28 29" type="primary">Itgb1bp1</name>
        <name evidence="24" type="ORF">I79_023271</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28 29" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28 29">17A/GY</strain>
            <tissue evidence="28 29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH002781">
        <property type="protein sequence ID" value="EGW13809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514174.1">
        <property type="nucleotide sequence ID" value="XM_003514126.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016818909.1">
        <property type="nucleotide sequence ID" value="XM_016963420.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280499.1">
        <property type="nucleotide sequence ID" value="XM_027424698.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280500.1">
        <property type="nucleotide sequence ID" value="XM_027424699.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IHI1"/>
    <dbReference type="STRING" id="10029.G3IHI1"/>
    <dbReference type="PaxDb" id="10029-XP_007633523.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000874.1">
        <property type="protein sequence ID" value="ENSCGRP00001000850.1"/>
        <property type="gene ID" value="ENSCGRG00001000664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759099"/>
    <dbReference type="KEGG" id="cge:100759099"/>
    <dbReference type="CTD" id="9270"/>
    <dbReference type="eggNOG" id="ENOG502QS6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003990"/>
    <dbReference type="OMA" id="QCSIWVY"/>
    <dbReference type="OrthoDB" id="10060702at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell adhesion mediated by integrin"/>
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        <property type="term" value="P:tube formation"/>
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    <dbReference type="CDD" id="cd13163">
        <property type="entry name" value="PTB_ICAP1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Integrin beta-1-binding protein 1"/>
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        <property type="entry name" value="Integrin-bd_ICAP-1"/>
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        <property type="entry name" value="PTB/PI_dom"/>
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        <property type="entry name" value="INTEGRIN BETA-1-BINDING PROTEIN 1"/>
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        <property type="entry name" value="INTEGRIN BETA-1-BINDING PROTEIN 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="9" id="KW-0091">Biomineralization</keyword>
    <keyword evidence="12" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="24 28 29" id="KW-0401">Integrin</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0497">Mitogen</keyword>
    <keyword evidence="13" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PID" evidence="23">
        <location>
            <begin position="57"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00073517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGW13809.1"/>
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    <evidence type="ECO:0000313" key="25">
        <source>
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    <evidence type="ECO:0000313" key="26">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027280499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027280500.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21599" checksum="B7BD0240582D1ED7" modified="2011-11-16" version="1">MFRKGKKRHSSSSSQSSEVSTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNNLDTCAEFRIKYVGAIEKLDLSQGKSLQGPLDLINYIDVAQQDGKLPFVPLEEEFILGVSKYGIKVSTTDQHGVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSDKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>P28681</accession>
    <name>OPSD_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RHO</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Mol. Biol." volume="224" first="343" last="358">
            <title>Localization and DNA sequence of a replication origin in the rhodopsin gene locus of Chinese hamster cells.</title>
            <authorList>
                <person name="Gale J.M."/>
                <person name="Tobey R.A."/>
                <person name="D'Anna A."/>
            </authorList>
            <dbReference type="PubMed" id="1560457"/>
            <dbReference type="DOI" id="10.1016/0022-2836(92)90999-Z"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <tissue>Ovary</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 3">Homodimer (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG. Interacts with GNAT1. Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability. Forms a complex with ASAP1 and ARF4. Forms a complex with ASAP1, RAB11A, Rabin8/RAB3IP, ARF4 and RAB11FIP3; the complex regulates Golgi-to-cilia rhodopsin/RHO transport in photoreceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Photoreceptor outer segment</location>
        </subcellularLocation>
        <text evidence="3">Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="X61084">
        <property type="protein sequence ID" value="CAA43398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S23398">
        <property type="entry name" value="S23398"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001231336.1">
        <property type="nucleotide sequence ID" value="NM_001244407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P28681"/>
    <dbReference type="SMR" id="P28681"/>
    <dbReference type="GlyCosmos" id="P28681">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-NP_001231336.1"/>
    <dbReference type="GeneID" id="100689279"/>
    <dbReference type="KEGG" id="cge:100689279"/>
    <dbReference type="CTD" id="6010"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962323at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097381">
        <property type="term" value="C:photoreceptor disc membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060342">
        <property type="term" value="C:photoreceptor inner segment membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042622">
        <property type="term" value="C:photoreceptor outer segment membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005502">
        <property type="term" value="F:11-cis retinal binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016038">
        <property type="term" value="P:absorption of visible light"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AgBase"/>
    </dbReference>
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        <property type="term" value="P:G protein-coupled opsin signaling pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="7tmA_MWS_opsin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
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        <property type="entry name" value="Retinal_BS"/>
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        <property type="entry name" value="Rhodopsin"/>
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        <property type="entry name" value="Rhodopsin_N"/>
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    <dbReference type="PANTHER" id="PTHR24240">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10413">
        <property type="entry name" value="Rhodopsin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
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        <property type="entry name" value="RHODOPSIN"/>
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    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0966">Cell projection</keyword>
    <keyword id="KW-0157">Chromophore</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0297">G-protein coupled receptor</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
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    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0844">Vision</keyword>
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        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="62"/>
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            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="6">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
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    <feature type="topological domain" description="Cytoplasmic" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="1">
        <location>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="6">
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    <feature type="transmembrane region" description="Helical; Name=5" evidence="1">
        <location>
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            <end position="224"/>
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    </feature>
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            <begin position="225"/>
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        <location>
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        </location>
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    <feature type="short sequence motif" description="'Ionic lock' involved in activated form stabilization" evidence="1">
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            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
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    <feature type="site" description="Plays an important role in the conformation switch to the active conformation" evidence="1">
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        <location>
            <position position="1"/>
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    <feature type="modified residue" description="N6-(retinylidene)lysine" evidence="1">
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            <position position="296"/>
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            <position position="334"/>
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            <position position="2"/>
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        <location>
            <position position="15"/>
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            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
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            <dbReference type="UniProtKB" id="P02700"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00521"/>
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    <sequence length="348" mass="39097" checksum="A5CDF27804F30AA1" modified="1992-12-01" version="1">MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVICKPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVILMVVFFLICWFPYAGVAFYIFTHQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGKNILGDDEASATASKTETSQVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-08-16" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6E6J8</accession>
    <name>Q6E6J8_CRIGR</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2004" name="Chromosome Res." volume="12" first="483" last="493">
            <title>Cloning, characterization and localization of Chinese hamster HP1 isoforms.</title>
            <authorList>
                <person name="Szakal B."/>
                <person name="Cserpan I."/>
                <person name="Csonka E."/>
                <person name="Monostori E."/>
                <person name="Udvardy A."/>
                <person name="Hadlaczky G."/>
            </authorList>
            <dbReference type="PubMed" id="15252244"/>
            <dbReference type="DOI" id="10.1023/B:CHRO.0000034750.34633.3c"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
            <authorList>
                <person name="Becker J."/>
                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
            </authorList>
            <dbReference type="PubMed" id="21945585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="NM_001246702.1"/>
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        <property type="nucleotide sequence ID" value="XM_027433439.1"/>
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        <property type="evidence" value="ECO:0000250"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB"/>
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        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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        <property type="project" value="UniProtKB"/>
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        <property type="project" value="UniProtKB"/>
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        <property type="project" value="UniProtKB"/>
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        <property type="project" value="UniProtKB"/>
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        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CBX3_chromo_domain"/>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
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        <property type="entry name" value="Chromo_dom_subgr"/>
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        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAT40863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="NP_001233631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027289240.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20811" checksum="5928C63E0C93A76A" modified="2004-08-16" version="1">MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I238</accession>
    <name>A0A061I238_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hematopoietic lineage cell-specific protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hematopoietic cell-specific LYN substrate 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">LckBP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Hcls1</name>
        <name evidence="14" type="ORF">H671_4g12845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE675543">
        <property type="protein sequence ID" value="ERE75198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300606.1">
        <property type="nucleotide sequence ID" value="XM_035444715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I238"/>
    <dbReference type="GeneID" id="100764646"/>
    <dbReference type="KEGG" id="cge:100764646"/>
    <dbReference type="CTD" id="3059"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030854">
        <property type="term" value="P:positive regulation of granulocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11959">
        <property type="entry name" value="SH3_Cortactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000139">
        <property type="entry name" value="Hematopoietic cell-specific Lyn substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035716">
        <property type="entry name" value="Cortactin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003134">
        <property type="entry name" value="Hs1_Cortactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF5">
        <property type="entry name" value="HEMATOPOIETIC LINEAGE CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02218">
        <property type="entry name" value="HS1_rep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51090">
        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="417"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE75198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035300606.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52940" checksum="E6BC3AE7A4E52C40" modified="2014-09-03" version="1">MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRSKVSEEHDILKKKELESGPKASHGYGGRFGVERDRMDKSAVGHEYVADVEKHSSQTDAARGFGGKYGVERDRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYTKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESMAEEKRKREEEEKAQQMARQQQERKAVVKMSREAQQPSEPVEKPAVPAPLPKKISSEVWPPAENHPPPEPEPVRSREEHPVPSLPMMQTQPQNSLEDNEEPPALPPRTPEGLQVVEEPVYEAEPEHEPENDYEDVMDLGRQEEEAEGDYEDVLEPEGTTSLSYQAGSSARAGGPGTSAVALYDYQGEGSDELSFDPDDIITDIEMVDEGWWRGRCHGHFGLFPANYVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
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                <person name="Galosy S."/>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">17A/GY</strain>
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    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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            <strain evidence="18">17A/GY</strain>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
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        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
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                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
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                <person name="Galosy S."/>
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                <person name="Wienberg J."/>
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                <person name="Grillari J."/>
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                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
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    <reference evidence="17" key="5">
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
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    <comment type="subcellular location">
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    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE673191">
        <property type="protein sequence ID" value="ERE78078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514032.1">
        <property type="nucleotide sequence ID" value="XM_003513984.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260823.1">
        <property type="nucleotide sequence ID" value="XM_027405022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I7T9"/>
    <dbReference type="GeneID" id="100775016"/>
    <dbReference type="KEGG" id="cge:100775016"/>
    <dbReference type="OMA" id="NYSADQV"/>
    <dbReference type="OrthoDB" id="9873506at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15416">
        <property type="entry name" value="7tmA_OR5P-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE78078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027260823.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34358" checksum="D88B23624B429C70" modified="2014-09-03" version="1">METGNDTMVTEFIILGLTDSPTLRAILFVFFLPVYIVTVFGNVSIILLIRSSPQLHTPMYLFLSHLAFVDIGYSTSVTPIMLISFLREKTTIPLSGCAAQLGSDVAFGTTECFLLATMAYDRYVAICSPLLYSTQMSPAVCLFLLGASYLGGCMNASSFTGCFVNLNFCGPNKINHFFCDLFPLVKLSCGHAYIAEISPSISSASVLVSTLSTIIVSYIYILLSIIRMRSTEGRNKAFSTCTSHLTAVTLFYGTVLFVYVMPKSSYSADQVKVASVIYTVVIPMLNPLIYSLRNKEVKEAMKKLMARTNWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IN25</accession>
    <name>A0A061IN25_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Achaete-scute family bHLH transcription factor 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Achaete-scute homolog 4-like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Putative achaete-scute-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">LOC113832927</name>
        <name evidence="7" type="ORF">H671_1g2845</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="KE665483">
        <property type="protein sequence ID" value="ERE88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247676.1">
        <property type="nucleotide sequence ID" value="XM_027391875.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IN25"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010077.1">
        <property type="protein sequence ID" value="ENSCGRP00001006418.1"/>
        <property type="gene ID" value="ENSCGRG00001008661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113832927"/>
    <dbReference type="KEGG" id="cge:113832927"/>
    <dbReference type="GeneTree" id="ENSGT00940000162902"/>
    <dbReference type="OrthoDB" id="5976910at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000038">
        <property type="entry name" value="achaete-scute homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ERE88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027247676.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16084" checksum="A5DCE21AB1701646" modified="2014-09-03" version="1">MEKRKPAGLLALPSPLRTPPLGALSRREPGRSSARQDAEDSARRRPCPSLSLGGVGEPASLRQRNERERQRVRCVNEGYARLRQHLPRELAGQRLSKVETLRAAISYIRHLQELLERHRRDCNSDGESKASSGASPCSEPEERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HGA3</accession>
    <name>A0A3L7HGA3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Acetylcholine receptor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Chrna1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">One of the alpha chains that assemble within the acetylcholine receptor, a pentamer of two alpha chains, a beta, a delta, and a gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003498376.1">
        <property type="nucleotide sequence ID" value="XM_003498328.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275854.1">
        <property type="nucleotide sequence ID" value="XM_027420053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HGA3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025699.1">
        <property type="protein sequence ID" value="ENSCGRP00001021455.1"/>
        <property type="gene ID" value="ENSCGRG00001020291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755935"/>
    <dbReference type="KEGG" id="cge:100755935"/>
    <dbReference type="CTD" id="1134"/>
    <dbReference type="GeneTree" id="ENSGT00940000156851"/>
    <dbReference type="OMA" id="GHITWNP"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19014">
        <property type="entry name" value="LGIC_ECD_nAChR_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000013">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000016">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000019">
        <property type="entry name" value="Putative acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 28" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 22" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044515799" description="Acetylcholine receptor subunit alpha" evidence="22">
        <location>
            <begin position="21"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="23">
        <location>
            <begin position="24"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="24">
        <location>
            <begin position="238"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027275854.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51924" checksum="8D79DECA4885C4F1" modified="2019-02-13" version="1">MELPTFLLLLGLCSAGLVLGSEHETRLVAELFKDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVNQIVTTNIRLKQQWVDCNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGHITWTPPAIYKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKEARGWKHWVFYSCCPNTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHTMPEWVRKVFIDTIPNIMFFSTMKRPSRDKQEKKIFTEDIDISDISGKPGPPPVGFHSPLIKHPEVKSAIEGVKYIAETMKSDQESNNASEEWKYVAMVMDHILLGVFMLVCLIGTLAVFAGRLIELHQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HI87</accession>
    <name>A0A3L7HI87_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">26S proteasome regulatory subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">26S proteasome AAA-ATPase subunit RPT2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proteasome 26S subunit ATPase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Psmc1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC1 and few additional components. Interacts with SCA7. Interacts with NGLY1. Interacts with PAAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003501438.1">
        <property type="nucleotide sequence ID" value="XM_003501390.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274900.1">
        <property type="nucleotide sequence ID" value="XM_027419099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HI87"/>
    <dbReference type="SMR" id="A0A3L7HI87"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031261.1">
        <property type="protein sequence ID" value="ENSCGRP00001027014.1"/>
        <property type="gene ID" value="ENSCGRG00001024151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770051"/>
    <dbReference type="KEGG" id="cge:100770051"/>
    <dbReference type="CTD" id="5700"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 20" id="KW-0647">Proteasome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027274900.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49185" checksum="ACA80782F4F96F49" modified="2019-02-13" version="1">MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HVL0</accession>
    <name>A0A3L7HVL0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein-coupled receptor 137B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Integral membrane protein GPR137B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Gpr137b</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027265244.1">
        <property type="nucleotide sequence ID" value="XM_027409443.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HVL0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019492.1">
        <property type="protein sequence ID" value="ENSCGRP00001015252.1"/>
        <property type="gene ID" value="ENSCGRG00001015900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764875"/>
    <dbReference type="KEGG" id="cge:100764875"/>
    <dbReference type="CTD" id="7107"/>
    <dbReference type="GeneTree" id="ENSGT00940000153986"/>
    <dbReference type="OrthoDB" id="192544at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045779">
        <property type="term" value="P:negative regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045671">
        <property type="term" value="P:negative regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150032">
        <property type="term" value="P:positive regulation of protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21476">
        <property type="entry name" value="7tm_GPR137B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029723">
        <property type="entry name" value="GPR137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146:SF0">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027265244.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44007" checksum="F2C964E9E23FE54F" modified="2019-02-13" version="1">MEAPPWEPVRNDSLPPTLSPAVPPYVKLGLTAVYTAFYALLFVFIYAQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFRDFVAANSFSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLTCAVLVKTGTWERKVIVSVRVAINDTLFVLCAISLSICLYKISKMSLANIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQMKNVHSFDYDWYNVSDQADLKSQLGDAGYVVFGVVLFVWELLPTTLVVYFFRVRNPTKDLSNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGSFAPDYYDWGQQSNSSLAQAGLLQQDSTLDPDKASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HZQ4</accession>
    <name>A0A3L7HZQ4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NEDD4-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">N4bp1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the N4BP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027261318.1">
        <property type="nucleotide sequence ID" value="XM_027405517.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HZQ4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017012.1">
        <property type="protein sequence ID" value="ENSCGRP00001012777.1"/>
        <property type="gene ID" value="ENSCGRG00001014095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750417"/>
    <dbReference type="KEGG" id="cge:100750417"/>
    <dbReference type="CTD" id="9683"/>
    <dbReference type="GeneTree" id="ENSGT00940000158682"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001818">
        <property type="term" value="P:negative regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045088">
        <property type="term" value="P:regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22476">
        <property type="entry name" value="KH-I_N4BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09032">
        <property type="entry name" value="KH-I_N4BP1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18728">
        <property type="entry name" value="PIN_N4BP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056629">
        <property type="entry name" value="KH_N4BP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056630">
        <property type="entry name" value="KH_N4BP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056631">
        <property type="entry name" value="UBA_N4BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056578">
        <property type="entry name" value="UBA_N4BP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF26">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23050">
        <property type="entry name" value="KH_N4BP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23052">
        <property type="entry name" value="KH_N4BP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23053">
        <property type="entry name" value="UBA_N4BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23054">
        <property type="entry name" value="UBA_N4BP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="N4BP1 first type I KH-domain" evidence="13">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="N4BP1 second type I KH-domain" evidence="14">
        <location>
            <begin position="75"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="N4BP1 UBA-like" evidence="15">
        <location>
            <begin position="346"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="RNase NYN" evidence="12">
        <location>
            <begin position="618"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="N4BP1 C-terminal UBA" evidence="16">
        <location>
            <begin position="849"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="491"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="800"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23050"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF23052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
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            <dbReference type="Pfam" id="PF23053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
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            <dbReference type="Pfam" id="PF23054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027261318.1"/>
        </source>
    </evidence>
    <sequence length="897" mass="99773" checksum="7A6E8E6D31574506" modified="2019-02-13" version="1">MAARVVLDEFTAPAEKAALLERSRGRIEALFGVGLAVLGVLGAEEPLPARIWLQLRGAQEAVHSAKEYIKGICEPELEEKECYPKAMHCIFVGAQSLFLKSLIQDTCADLCILDTGLLGIRGSAEAVVMARSHIQQFVKLFENNENLPSSQKESEIKREFRQFVEAHADNYTMDLLILPTSLKKELLSLTQGEESLFETGDDDVIKIGDVRPSELTQNAATGPSIARDEVVSQEDSRSKARTPVSELTKQMDEVFSSSADVLFVPVNGLSPDEDALSKDRVCHKRRSSDTEERHTKKQFSLENVPEGELVHDGKASAGNEVIDLSDDASNSTNLSPDGKDTTEEMEYNILVNFFKTMGYSQEIVEKVIREYGPSTEPLLLLEEIEKENKRLQEDRALPPGSVYPDAAQSRSMGAGSSTNELTTDSTPKKTQSHTEQNMVEKFSQLPFKDSKPCTSNCRINSFRTVPVGQKHEMWGSPQNYSCNVDLETDGLSPSVASSSPKEVSFISRGPAGHQQRSPAFPENGFQQQAEPPLPNNTKPACEKRSGCCNSPQPKPNYPPLSPPMPRPQPHLLPSVTDTRLAGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRADLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNVTEQHFLTQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKRLLQYTFVGDIFMVPDDPLGRNGPRLEEFLRKEVFLRDMQPILNVLPNVGTFDPGFRSPNTQIANTSHQPPSRNQGASSGSWLPQQPHFTPLATLPSIQQNLPMPAQRSSAETSELREALLKIFPDSEQKLKIDQILVAHPYMKDLNALSALVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I9A5</accession>
    <name>A0A3L7I9A5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 43, member B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Protein FAM43B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">LOC113833873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035295006.1">
        <property type="nucleotide sequence ID" value="XM_035439115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I9A5"/>
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        <property type="protein sequence ID" value="ENSCGRP00001005060.1"/>
        <property type="gene ID" value="ENSCGRG00001006594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113833873"/>
    <dbReference type="KEGG" id="cge:113833873"/>
    <dbReference type="GeneTree" id="ENSGT00940000162826"/>
    <dbReference type="OrthoDB" id="5962185at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01214">
        <property type="entry name" value="PTB_FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033930">
        <property type="entry name" value="FAM43A/B_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF34">
        <property type="entry name" value="PROTEIN FAM43B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="67"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035295006.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36948" checksum="6935C67231101B69" modified="2019-02-13" version="1">MLPWRRNKFVLVEDEAKRKAKSLSPGLAYTSLLSSFLRSCPDLLPDWPLERLGRVFRSRRQKVELNKEDPTYTVWYLGNAVTLHAKGDGCTDDAVGRIWARCGPGGGTKMKLTLGPHGIRMQPSERGAGGSGGRRPAHAYLLPRITYCAADGRHPRVFAWVYRHQARHKAVVLRCHAVLLARAHKARSLARLLRQTALAAFSDFKRLQRQSDARHVRQQHLRAGGAAASVPRAPLRRLLNAKCAYRPPPGERGRGAPRLSSIQEEDEEEEGAEEEDSRDSEGGALQHERPEVLSLTRELRTCSLRSAAAPPPPAQPRRWKASSRERAGQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7ID00</accession>
    <name>A0A3L7ID00_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase 17B</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">DAP kinase-related apoptosis-inducing protein kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 29 30 31" type="primary">Stk17b</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29 30 31" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29 30 31">17A/GY</strain>
            <tissue evidence="29 30 31">Liver</tissue>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027252678.1">
        <property type="nucleotide sequence ID" value="XM_027396877.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252679.1">
        <property type="nucleotide sequence ID" value="XM_027396878.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252680.1">
        <property type="nucleotide sequence ID" value="XM_027396879.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7ID00"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020503.1">
        <property type="protein sequence ID" value="ENSCGRP00001016259.1"/>
        <property type="gene ID" value="ENSCGRG00001016645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753074"/>
    <dbReference type="KEGG" id="cge:100753074"/>
    <dbReference type="CTD" id="9262"/>
    <dbReference type="GeneTree" id="ENSGT00940000154014"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000271">
        <property type="term" value="P:positive regulation of fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14198">
        <property type="entry name" value="STKc_DRAK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000422">
        <property type="entry name" value="serine/threonine-protein kinase 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000175">
        <property type="entry name" value="Serine/threonine-protein kinase 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042763">
        <property type="entry name" value="ST17B_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12 22 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 29 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 22 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 23" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="33"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="305"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027252678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027252679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027252680.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42115" checksum="330AFB4DB1818DDB" modified="2019-02-13" version="1">MSRRRFDCRSSSGLLTTTPQTPMKTENFNNFYTLTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELARACPHVINLHEVYENATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGNACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSDETFSSVSQLATDFIQSLLVKNPEKRLTAESCLSHSWLQQWDFGSLFHPEETSGSSQIQDHTLRSSEDKTPKSSCNGSCGDREDKENIPEDSSMVSKRFRFDDSLPSPHELVPDLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2L6T4</accession>
    <name>A0A8C2L6T4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine-rich glycoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Histidine-proline-rich glycoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Hrg</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027268788.1">
        <property type="nucleotide sequence ID" value="XM_027412987.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2L6T4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000373.1">
        <property type="protein sequence ID" value="ENSCGRP00001000349.1"/>
        <property type="gene ID" value="ENSCGRG00001000289.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764582"/>
    <dbReference type="KEGG" id="cge:100764582"/>
    <dbReference type="CTD" id="3273"/>
    <dbReference type="GeneTree" id="ENSGT00950000182930"/>
    <dbReference type="OrthoDB" id="9941887at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043395">
        <property type="term" value="F:heparan sulfate proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019865">
        <property type="term" value="F:immunoglobulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051838">
        <property type="term" value="P:cytolysis by host of symbiont cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033629">
        <property type="term" value="P:negative regulation of cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001027">
        <property type="term" value="P:negative regulation of endothelial cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051918">
        <property type="term" value="P:negative regulation of fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010593">
        <property type="term" value="P:negative regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900747">
        <property type="term" value="P:negative regulation of vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000504">
        <property type="term" value="P:positive regulation of blood vessel remodeling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051894">
        <property type="term" value="P:positive regulation of focal adhesion assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002839">
        <property type="term" value="P:positive regulation of immune response to tumor cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010543">
        <property type="term" value="P:regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000015">
        <property type="entry name" value="Histidine-rich glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050735">
        <property type="entry name" value="Kininogen_Fetuin_HRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814">
        <property type="entry name" value="FETUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814:SF3">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0280">Fibrinolysis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="3" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678416" description="Histidine-rich glycoprotein" evidence="16">
        <location>
            <begin position="30"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="17">
        <location>
            <begin position="23"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="17">
        <location>
            <begin position="148"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="285"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="349"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027268788.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="60437" checksum="E544099AB1BF4D17" modified="2022-01-19" version="1">MGDHSLGWFSTMNVLTTALLLVTLQYCHALSPTNCDASEPSAERVLDLINKGRRNGYAFELLRVADAHLDRVGNATVYYLVLDVKESDCWVLSTKSRDACLLDVSRRPSEIVIGQCKVIATRYSDESQDFRVNNYNCTTSSVSSALSNTKDSPVLLDFFEDSEPYREQANTALDKYKWENSDFGSFRVERIERVIRARGGKRTNYYLDFSMRNCSTQHFPRHPPVFGFCRAVLSYDVEASNLETPKDTDINCEVFNFEDRNMSDIKPHWGHEHSCGKHLCKFSGSRGHHHTHKMYEHGYPPPPEGEEDSDRPPPQDRSLPQPPPRHSSPFGTNRAHRPPHNHSCNEHVSHRHPPHGHHRHGHPPHGHHPHGHPPHGHHPHGHPPHGHHPHGHPPHGHPPHGHPPHGHHPHGHPPHGHDFHDYGPCDPPSNSQKLKGQYHGDHGPPHGHSRKRGSGKGFSPFHHQEIGNVYRLPPLSTGEVLDVPEANFPSISPPNCNNPLQPEIQSFPEAASKSCPGKFRSEFPQIHKFFANMPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LCG5</accession>
    <name>A0A8C2LCG5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5 8">Serine protease 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Prss33</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_003513457.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280629.1">
        <property type="nucleotide sequence ID" value="XM_027424828.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LCG5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001777.1">
        <property type="protein sequence ID" value="ENSCGRP00001001592.1"/>
        <property type="gene ID" value="ENSCGRG00001001379.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772402"/>
    <dbReference type="KEGG" id="cge:100772402"/>
    <dbReference type="CTD" id="260429"/>
    <dbReference type="GeneTree" id="ENSGT00940000162519"/>
    <dbReference type="OMA" id="DARTCDR"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brain-specific serine protease 4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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        <property type="entry name" value="Peptidase_S1A"/>
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    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
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        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF58">
        <property type="entry name" value="SERINE PROTEASE 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
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        <location>
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            <end position="277"/>
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        <location>
            <begin position="34"/>
            <end position="276"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027280629.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="29597" checksum="AA95893D460A0655" modified="2022-01-19" version="1">MRGASHLQILFLLVLGARMQRCAACGQPRMSSRIVGGRDAGDGEWPWQTSIQHRGVHVCGGSLVAPQWVLTAAHCFPRRVVPSEYSVLLGALSLGVTSSHELLVPVLRVLLPPDYSEDEARGDLALLQLRHPVSLSARIQPVCLPAPGSHPPPGSPCWVTGWGSLSPGVPLPEGRPLQGVRVPLLDSGACDRLYHVGANVPQGERIVLPGNLCAGYRRGHKDACQGDSGGPLTCLQSGRWVLVGVVSWGKGCALPNRPGVYTNVAKYSPWIQAHLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LGM6</accession>
    <name>A0A8C2LGM6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Complement C1q subcomponent subunit C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Complement component 1, q subcomponent, C chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">C1qc</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035295036.1">
        <property type="nucleotide sequence ID" value="XM_035439145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312560.1">
        <property type="nucleotide sequence ID" value="XM_035456669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LGM6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001004852.1">
        <property type="protein sequence ID" value="ENSCGRP00001003377.1"/>
        <property type="gene ID" value="ENSCGRG00001004076.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769576"/>
    <dbReference type="KEGG" id="cge:100769576"/>
    <dbReference type="CTD" id="714"/>
    <dbReference type="GeneTree" id="ENSGT00940000161227"/>
    <dbReference type="OMA" id="RGTNEYP"/>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005602">
        <property type="term" value="C:complement component C1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062167">
        <property type="term" value="C:complement component C1q complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098890">
        <property type="term" value="C:extrinsic component of postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098888">
        <property type="term" value="C:extrinsic component of presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106139">
        <property type="term" value="C:symbiont cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019864">
        <property type="term" value="F:IgG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001791">
        <property type="term" value="F:IgM binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030853">
        <property type="term" value="P:negative regulation of granulocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045650">
        <property type="term" value="P:negative regulation of macrophage differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098883">
        <property type="term" value="P:synapse pruning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000001">
        <property type="entry name" value="Complement C1q B chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF29">
        <property type="entry name" value="COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678521" evidence="6">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="115"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035295036.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="25837" checksum="9ED8D76403D1BC18" modified="2022-01-19" version="1">MDVGPSCQPQRGLYLTLLLLALTLRSQANTNCYGIPGMPGLPGAPGKDGHDGLPGPKGERGIPAIPGTRGPKGQKGEPGMPGYRGKNGPMGPSGLPGDPGPRGPPGEPGEEGRYKQKHQSVFTVTRQTAQYPAANGLVKFNSVVTNPQGDYDTSTGKFTCKVPGLYYFVYHASQTANLCVQLLHNSAKVTTFCDHMSNSKQVSSGGVLLRLQKGDEVWLAVNDYNGMVGTEGSDSVFSGFLLFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LKX7</accession>
    <name>A0A8C2LKX7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heterogeneous nuclear ribonucleoprotein A/B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Hnrnpab</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027283406.1">
        <property type="nucleotide sequence ID" value="XM_027427605.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LKX7"/>
    <dbReference type="SMR" id="A0A8C2LKX7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005974.1">
        <property type="protein sequence ID" value="ENSCGRP00001004035.1"/>
        <property type="gene ID" value="ENSCGRG00001005044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767538"/>
    <dbReference type="KEGG" id="cge:100767538"/>
    <dbReference type="CTD" id="3182"/>
    <dbReference type="GeneTree" id="ENSGT00940000154735"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000623">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12757">
        <property type="entry name" value="RRM1_hnRNPAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12584">
        <property type="entry name" value="RRM2_hnRNPAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000186">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein A/B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000030">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein d0 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012956">
        <property type="entry name" value="CARG-binding_factor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034846">
        <property type="entry name" value="hnRNPAB_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF1">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08143">
        <property type="entry name" value="CBFNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="20" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="75"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="159"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027283406.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36347" checksum="3585087C8D68755C" modified="2022-01-19" version="1">MSDAAEEQPMETTGATENGHEAAPEGEAPVEPGAGAPAPAAPAASGGGTTATPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDSSSVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPKLNKRRGFVFITYKEEDPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGQSQSWNQGYGNYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LPX1</accession>
    <name>A0A8C2LPX1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="14">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 14">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Cct7</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the chaperonin-containing T-complex (TRiC), a hexadecamer composed of two identical back-to-back stacked rings enclosing a protein folding chamber. Each ring is made up of eight different subunits: TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A/CCT6, CCT7, CCT8. Interacts with PACRG. Interacts with DLEC1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027284552.1">
        <property type="nucleotide sequence ID" value="XM_027428751.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LPX1"/>
    <dbReference type="SMR" id="A0A8C2LPX1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012006.1">
        <property type="protein sequence ID" value="ENSCGRP00001007918.1"/>
        <property type="gene ID" value="ENSCGRG00001010276.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770561"/>
    <dbReference type="KEGG" id="cge:100770561"/>
    <dbReference type="CTD" id="10574"/>
    <dbReference type="GeneTree" id="ENSGT00550000074832"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002199">
        <property type="term" value="C:zona pellucida receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027284552.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="59469" checksum="7E2CE69BA0E03E7F" modified="2022-01-19" version="1">MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVDKIKEIAVTVKKQDKVEQRKMLEKCAMTALSSKLISQQKTFFAKMVVDAVMMLDELLQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHQSGAKVILSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALIPDVLGHCQLFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDVNNEDIADNFQAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPAGAGRGRGQGRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LR41</accession>
    <name>A0A8C2LR41_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Kif20a</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035296094.1">
        <property type="nucleotide sequence ID" value="XM_035440203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LR41"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012065.1">
        <property type="protein sequence ID" value="ENSCGRP00001007973.1"/>
        <property type="gene ID" value="ENSCGRG00001010312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773707"/>
    <dbReference type="KEGG" id="cge:100773707"/>
    <dbReference type="CTD" id="10112"/>
    <dbReference type="GeneTree" id="ENSGT00940000156931"/>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01368">
        <property type="entry name" value="KISc_KIF23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21787">
        <property type="entry name" value="RBD_KIF20A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000094">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000095">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF29">
        <property type="entry name" value="KINESIN FAMILY MEMBER 20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 17" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13 16 17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="20">
        <location>
            <begin position="63"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="821"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="609"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035296094.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="100478" checksum="0744010273738EC3" modified="2022-01-19" version="1">MDHGILSPPADLLSDEDVLVSPMFESTAADLRSVIRKDLLSECSVISTSLEDKQAPFEDTAERVKVYLRIRPFLTSELDRQEDQGCVRIENTETLMLQAPKDSFALKSNERGIGQATHKFTFSQIFGPEVGQAPFFNLAVKEMVKDVLKGQNWLIYTYGVTNSGKTYTVQGTIKDGGILPRSLALIFNSLQGQLHTTPDLKPLLSNEVIWLDSKQVRQEELKKLSLLTGGLQEELSTSLKKRVHIDSRLGTSTSFDSGIAGLSSTSQFTSSSQLDETSQSWAQPDTAPVSVPADIRFSVWISFFEIYNELLYDLLESPSHQHKRQTLRLCEDQNGNPYVKDLNWIHVRDVEEAWKLLKVGRKNQSFANTHLNQNSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKDQRSGERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLIPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFSALASQLVHAPPVHLGIPSLHSFIKEHSLQVSPGLKKGDHTDSGLDDHPENEADISMYGKEELLQVVEAMKTLILKERQEKLQLEMQLREEICNEMVEQMQQREQWCSEHLDHQKELLEELYEEKLKILKESLTSFYQEEIQERDEKIEELETLLQEAKQQQPVAQQSGSELSLRRSQRLAASASTQQLQEVTAKLEQCKAELNSTTEELQKYQQMLEPPPTAKPFTIDVDKKLEEGQKNIRMLRTELQKLGQSLQSAERACCHSTGAGKLRQALTNCDDILIKQNQTLAELQNNMMLVKLDLRKKAACIAEQYHTVLKLQNQASSSKKRLGTNQENQQPNHQPPGKKPFLRNLLPRTPTCQSSTDSGPYTRILRSRHSPLLRSPFGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LRG3</accession>
    <name>A0A8C2LRG3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">hypoxia-inducible factor-proline dioxygenase</fullName>
            <ecNumber evidence="11">1.14.11.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Egln1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:48400"/>
            <dbReference type="Rhea" id="RHEA-COMP:12093"/>
            <dbReference type="Rhea" id="RHEA-COMP:12094"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="11"/>
    <dbReference type="RefSeq" id="XP_007651724.2">
        <property type="nucleotide sequence ID" value="XM_007653534.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260614.1">
        <property type="nucleotide sequence ID" value="XM_027404813.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LRG3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011371.1">
        <property type="protein sequence ID" value="ENSCGRP00001007343.1"/>
        <property type="gene ID" value="ENSCGRG00001009766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772704"/>
    <dbReference type="KEGG" id="cge:100772704"/>
    <dbReference type="CTD" id="54583"/>
    <dbReference type="GeneTree" id="ENSGT00940000155704"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160082">
        <property type="term" value="F:hypoxia-inducible factor-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055008">
        <property type="term" value="P:cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060347">
        <property type="term" value="P:heart trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032364">
        <property type="term" value="P:intracellular oxygen homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060711">
        <property type="term" value="P:labyrinthine layer development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902072">
        <property type="term" value="P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045765">
        <property type="term" value="P:regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099159">
        <property type="term" value="P:regulation of modification of postsynaptic structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140252">
        <property type="term" value="P:regulation protein catabolic process at postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071731">
        <property type="term" value="P:response to nitric oxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060412">
        <property type="term" value="P:ventricular septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000005">
        <property type="entry name" value="Egl nine homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF4">
        <property type="entry name" value="EGL NINE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0847">Vitamin C</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="15">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="271"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027260614.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43326" checksum="1D27CC0FD48087EF" modified="2022-01-19" version="1">MASDSGGPGVLSASERDRQYCELCGKMENLLRCGRCRNSFYCCKEHQRQDWKKHKLVCQGGEVPRVQPAPAQPRVAPPPSGAPGAARVGGAARRGDSAAASRAPGPEDAAQARSGPGPAEPGSEDPPASRSPGPERASLCPAGGGPGEALSPSGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGRETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDQITWIEGKEPGCETIGLLMSSMDDLIRHCSGKLGNYRINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPNSVSKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LS15</accession>
    <name>A0A8C2LS15_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Tmem147</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TMEM147 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003505623.2">
        <property type="nucleotide sequence ID" value="XM_003505575.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286885.1">
        <property type="nucleotide sequence ID" value="XM_027431084.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LS15"/>
    <dbReference type="SMR" id="A0A8C2LS15"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011624.1">
        <property type="protein sequence ID" value="ENSCGRP00001007573.1"/>
        <property type="gene ID" value="ENSCGRG00001009966.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751744"/>
    <dbReference type="KEGG" id="cge:100751744"/>
    <dbReference type="CTD" id="10430"/>
    <dbReference type="GeneTree" id="ENSGT00390000013276"/>
    <dbReference type="OrthoDB" id="9993532at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160064">
        <property type="term" value="C:multi-pass translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160063">
        <property type="term" value="P:multi-pass transmembrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027286885.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25291" checksum="90122F32D71E53AE" modified="2022-01-19" version="1">MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLCSLGSWTALLARAVVTGLLALSTLALYVAVVNVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LSW0</accession>
    <name>A0A8C2LSW0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17 20">Cytochrome c, somatic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">LOC100773626</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 15">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="15">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003506659.1">
        <property type="nucleotide sequence ID" value="XM_003506611.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256326.1">
        <property type="nucleotide sequence ID" value="XM_027400525.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LSW0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012515.1">
        <property type="protein sequence ID" value="ENSCGRP00001008387.1"/>
        <property type="gene ID" value="ENSCGRG00001010686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773626"/>
    <dbReference type="KEGG" id="cge:100773626"/>
    <dbReference type="GeneTree" id="ENSGT00390000009405"/>
    <dbReference type="OMA" id="ARCKACH"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000008">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="16">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027256326.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11474" checksum="C46E470C070BF4D3" modified="2022-01-19" version="1">MGDAEKGKKISVQKCAQCHTVKKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGESTLMEYLDNPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M0J5</accession>
    <name>A0A8C2M0J5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine-rich protein 2-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ADA2A-containing complex subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CRP2-binding partner</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysine acetyltransferase 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Kat14</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003496515.2">
        <property type="nucleotide sequence ID" value="XM_003496467.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277426.1">
        <property type="nucleotide sequence ID" value="XM_027421625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M0J5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015674.1">
        <property type="protein sequence ID" value="ENSCGRP00001011442.1"/>
        <property type="gene ID" value="ENSCGRG00001013086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767721"/>
    <dbReference type="KEGG" id="cge:100767721"/>
    <dbReference type="CTD" id="57325"/>
    <dbReference type="GeneTree" id="ENSGT00390000001146"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000013">
        <property type="entry name" value="cysteine-rich protein 2-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.980.20:FF:000004">
        <property type="entry name" value="Cysteine-rich protein 2-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="637"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027277426.1"/>
        </source>
    </evidence>
    <sequence length="781" mass="88578" checksum="1B06C730936BD758" modified="2022-01-19" version="1">MMESNIHLSGLLSRHDDEATRTSTSEGLEEGEVEGETLLIVESEDQASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFFRFTCSDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHWTFLLGNRKKTSTWWSTVAGCLSVGSPVYFRSGAQEFGEPGWWKLVHNRPPTMRPEGEKLSASTLKVKASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGLLDRSTSSTPVKFISRARRPDMVLEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFSAPGTPASHSATPSLLSEADLIPDVMPPQALFHDDDELEGDGVIDPGMEYIPPPAGSAASGLVGSRKKVRAPEQIKQEEDSDEEKPDRMDGDSEDTDSNTSLHTRAREKRKPPLEKDVKPKGPRYAPVSIYEEKLLLKRLEACPSAVAMTPEARRLKRKLIIRQAKRDRGLPLFDLDEVVNAALLLVDGIYGAKDGGASRLPAGQATYRTTCQDFRILDRYQTALPTRKGFRHQTTRFLYRLVGSEDLAVDQSIVSPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSDPHWTPEPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKVIVAFGFMVPDVKYNEAYISFLLVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M8N8</accession>
    <name>A0A8C2M8N8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBC1 domain family member 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Tbc1d20</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003511539.1">
        <property type="nucleotide sequence ID" value="XM_003511491.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277316.1">
        <property type="nucleotide sequence ID" value="XM_027421515.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSCGRT00001019503.1">
        <property type="protein sequence ID" value="ENSCGRP00001015263.1"/>
        <property type="gene ID" value="ENSCGRG00001015910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759085"/>
    <dbReference type="KEGG" id="cge:100759085"/>
    <dbReference type="CTD" id="128637"/>
    <dbReference type="OMA" id="VYMFAQI"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:lens fiber cell morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:lipid droplet organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation by virus of viral protein levels in host cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000024">
        <property type="entry name" value="TBC1 domain family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
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        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF10">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
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    <feature type="domain" description="Rab-GAP TBC" evidence="8">
        <location>
            <begin position="59"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00067516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027277316.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45795" checksum="B0CE806BF4D55E0F" modified="2022-01-19" version="1">MALRPSQGDGSAGRWNCGLGKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRCQVWPKLLNVNTCEPPPVSRKDLRQLSKDYQQVLLDVRRSLRRFPPGMPDEQREGLQEELIDIILLILDRNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPETRTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MBU8</accession>
    <name>A0A8C2MBU8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Meiosis-specific protein MEI4 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Meiotic double-stranded break formation protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Mei4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MEI4L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300393.1">
        <property type="nucleotide sequence ID" value="XM_035444502.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317353.1">
        <property type="nucleotide sequence ID" value="XM_035461462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MBU8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019698.1">
        <property type="protein sequence ID" value="ENSCGRP00001015456.1"/>
        <property type="gene ID" value="ENSCGRG00001016059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765662"/>
    <dbReference type="KEGG" id="cge:100765662"/>
    <dbReference type="CTD" id="101928601"/>
    <dbReference type="OMA" id="MYDITQY"/>
    <dbReference type="OrthoDB" id="6351423at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025888">
        <property type="entry name" value="MEI4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28575">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN MEI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28575:SF1">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN MEI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13971">
        <property type="entry name" value="Mei4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035300393.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44259" checksum="A478BDADCF294164" modified="2022-01-19" version="1">MDVQTWYLKTSKLALALAIIHSKPADRSSREYTEHLATLVAQKEPKCQSKVEALEAEVLQLRQQLFLSRISSGLFKNGHDVFPAVLPDQEPTSSENTLALMDDSGCVLSNEQRSEPAELSQHWLESCSPPSLLPLPLENKPYPALDNPPSSHMQFLQHLLELKKLTESSSLKIYLAHFEKDSSIVSESVLKLLDGLITFYRNPKLPSSSFWTQAVGTLARLASDFNLSNHILKKCSKKLEEFEKTLLQAIIGNSSINRFQVQHYVSQSLVTLGSCSVLRKSIILLLLSEVNSFVDHLGAINQDQGSYDVTRYENIFSLFWILEQLLQQEIQGDPALHIDHSSPEIQTFLQKHDETIFRLSDAFPLFTFYLWRLGILLNSAEMETVEKESFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MET4</accession>
    <name>A0A8C2MET4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ETS-related transcription factor Elf-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E74-like factor 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Elf5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035296828.1">
        <property type="nucleotide sequence ID" value="XM_035440937.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302351.1">
        <property type="nucleotide sequence ID" value="XM_035446460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MET4"/>
    <dbReference type="SMR" id="A0A8C2MET4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021990.1">
        <property type="protein sequence ID" value="ENSCGRP00001017746.1"/>
        <property type="gene ID" value="ENSCGRG00001017703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774069"/>
    <dbReference type="KEGG" id="cge:100774069"/>
    <dbReference type="CTD" id="2001"/>
    <dbReference type="GeneTree" id="ENSGT00940000160980"/>
    <dbReference type="OMA" id="MSWTELF"/>
    <dbReference type="OrthoDB" id="5961210at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001712">
        <property type="term" value="P:ectodermal cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060644">
        <property type="term" value="P:mammary gland epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060806">
        <property type="term" value="P:negative regulation of cell differentiation involved in embryonic placenta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060707">
        <property type="term" value="P:trophoblast giant cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000026">
        <property type="entry name" value="ETS homologous factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000244">
        <property type="entry name" value="ETS-related transcription factor Elf-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF15">
        <property type="entry name" value="ETS-RELATED TRANSCRIPTION FACTOR ELF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PNT" evidence="12">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="11">
        <location>
            <begin position="161"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035302351.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29967" checksum="8E631DED7DAB22FA" modified="2022-01-19" version="1">MLDSVTHSTFLPNTSFCDPLMSWTDLFSNEEYYPTFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAEETKTTIKDYADSSCLKTSGIKSQDCHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MEZ4</accession>
    <name>A0A8C2MEZ4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="20">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Galnt9</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Golgi apparatus membrane</location>
            <topology evidence="2 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="20"/>
    <dbReference type="RefSeq" id="XP_027271684.1">
        <property type="nucleotide sequence ID" value="XM_027415883.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MEZ4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021195.1">
        <property type="protein sequence ID" value="ENSCGRP00001016951.1"/>
        <property type="gene ID" value="ENSCGRG00001017127.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773797"/>
    <dbReference type="KEGG" id="cge:100773797"/>
    <dbReference type="CTD" id="50614"/>
    <dbReference type="OrthoDB" id="9924649at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23473">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000025">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000192">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000203">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF28">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 20" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="21">
        <location>
            <begin position="466"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027271684.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68632" checksum="13F16911DF492E5A" modified="2022-01-19" version="1">MAVARKIKTLLTVNILVFVGIILFSVYCRLQDRSEALVQVVRGADRRMRNRLSKASALADREAILQRLDHLEEVVYNQLNGLAKPIGLVEGPGGLGQGGVAATLQDDSQETEGKFEEFGYNAQLSDRISLDRTIPDYRPKRCKQITHPEDLPQISVVFIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKFNLDQYVHKRYPGLVKVVRNSRREGLIRARLQGWKVATAPVVGFFDAHVEFNTGWAEPALARIREDRRRIILPAIDNIKFSTFEVQQYASAAHGYNWGLWCMYIIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGAENIELGMRVWQCGGSMEVLPCSRVAHIERTKKPYNNDIDYYAKRNALRAAEVWMDDFKSHVYMAWNIPMTNPGVDFGDVSERLALRQKLKCRSFKWYLENVYPEMRIYNNTLTYGEVRNSKASGYCLDQGAEDDDRAILYPCHGMSSQLVRYSADGLLQLGPLGSTAFLPDSKCLVDDGRGRMPTLKKCEDVARPTQRLWDFTQSGPIVSRDTGRCLEVEMSKDANFGLRLVVQRCSGQKWMIRNWIKHTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MLR6</accession>
    <name>A0A8C2MLR6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Akirin 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Akirin-1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Akirin1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007643741.2">
        <property type="nucleotide sequence ID" value="XM_007645551.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255012.1">
        <property type="nucleotide sequence ID" value="XM_027399211.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MLR6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024889.1">
        <property type="protein sequence ID" value="ENSCGRP00001020645.1"/>
        <property type="gene ID" value="ENSCGRG00001019740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751284"/>
    <dbReference type="KEGG" id="cge:100751284"/>
    <dbReference type="CTD" id="79647"/>
    <dbReference type="GeneTree" id="ENSGT00940000158787"/>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014839">
        <property type="term" value="P:myoblast migration involved in skeletal muscle regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902725">
        <property type="term" value="P:negative regulation of satellite cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902723">
        <property type="term" value="P:negative regulation of skeletal muscle satellite cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010592">
        <property type="term" value="P:positive regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010759">
        <property type="term" value="P:positive regulation of macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22243">
        <property type="entry name" value="akirin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF9">
        <property type="entry name" value="AKIRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027255012.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21745" checksum="CF39ACFA358DDF68" modified="2022-01-19" version="1">MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPFQMQMPSTSLQQPALPSSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLSQSEACTSESQPPSSALTAPSSPGASWMKKDQPTFTLRQVGIICERLLKDYEDKVREEYEQILSTKLAEQYESFVKFTHDQIMRRYGTRPTSYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MM23</accession>
    <name>A0A8C2MM23_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">1-acylglycerol-3-phosphate O-acyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Agpat5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027245455.1">
        <property type="nucleotide sequence ID" value="XM_027389654.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MM23"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:nuclear envelope"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
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    </dbReference>
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        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="LPLAT_LCLAT1-like"/>
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    </dbReference>
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        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
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        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="8">
        <location>
            <begin position="87"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027245455.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="42091" checksum="B64586BA6908719A" modified="2022-01-19" version="1">MLLSLVLHTYSMRYLLPSVLLLGSAPTYLLAWTLWRVLSALLPARLYQRVDDRLYCVYQNMVLFFFENYTGVQILLYGDLPKNKENVIYLANHQSTVDWIIADMLAARQDALGHVRYVLKDGLKWLPLYGFYFAQHGGIYVKRSAKFNEKEMRNKLQSYVNAGTPMYLVIFPEGTRYNKTHTKLLSASQAFAAQRGLPVLKHVLTPRVKATHVAFDSMKSHLDAIYDVTVVYEGNEKGSGKYSNSPSMTDFLCKQCPKLHIHFDRIDKNEVPEEQEQMKIWLHERFEIKDKLLIEFYDSPDPERRNKFPGKSVHSRLSVKKTLPSVLILGSLTAVMLMTDSGRKLYVGTWLYGTLLGCLWFVIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQ24</accession>
    <name>A0A8C2MQ24_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Natd1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283068.1">
        <property type="nucleotide sequence ID" value="XM_027427267.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316207.1">
        <property type="nucleotide sequence ID" value="XM_035460316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MQ24"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025343.1">
        <property type="protein sequence ID" value="ENSCGRP00001021099.1"/>
        <property type="gene ID" value="ENSCGRG00001020036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756496"/>
    <dbReference type="KEGG" id="cge:100756496"/>
    <dbReference type="CTD" id="256302"/>
    <dbReference type="GeneTree" id="ENSGT00390000014840"/>
    <dbReference type="OrthoDB" id="74247at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000030">
        <property type="entry name" value="NATD1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027283068.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12731" checksum="07318CF74DFCC88A" modified="2022-01-19" version="1">MAHAAPPSALEQSGPIRVEHDRQRRQFSVRLNGCHDRAVLLYEYVGKRIVDLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLKAHLTCWYIQKYVKENPLPQYLERLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQN4</accession>
    <name>A0A8C2MQN4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor SOX-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Sox10</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027259784.1">
        <property type="nucleotide sequence ID" value="XM_027403983.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MQN4"/>
    <dbReference type="SMR" id="A0A8C2MQN4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026620.1">
        <property type="protein sequence ID" value="ENSCGRP00001022375.1"/>
        <property type="gene ID" value="ENSCGRG00001020938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754443"/>
    <dbReference type="KEGG" id="cge:100754443"/>
    <dbReference type="CTD" id="6663"/>
    <dbReference type="GeneTree" id="ENSGT00940000158046"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0022010">
        <property type="term" value="P:central nervous system myelination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048546">
        <property type="term" value="P:digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032808">
        <property type="term" value="P:lacrimal gland development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:morphogenesis of a branching epithelium"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:neural crest cell migration"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007422">
        <property type="term" value="P:peripheral nervous system development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0014015">
        <property type="term" value="P:positive regulation of gliogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF6">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="11">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="271"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00040805"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022375.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027259784.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="49949" checksum="84862547F039E71F" modified="2022-01-19" version="1">MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRASPGPGELGKVKKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGEAEQGGAAAIQAHYKSAHLDHRHPEEGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNVDIGEISHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLGSALAVASGHSAWISKPPGVALPTVSPPGVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MRA6</accession>
    <name>A0A8C2MRA6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box only protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Fbxo3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of a SCF (SKP1-cullin-F-box) protein ligase complex SCF(FBXO3) consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027278148.1">
        <property type="nucleotide sequence ID" value="XM_027422347.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296878.1">
        <property type="nucleotide sequence ID" value="XM_035440987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MRA6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025278.1">
        <property type="protein sequence ID" value="ENSCGRP00001021034.1"/>
        <property type="gene ID" value="ENSCGRG00001019997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755440"/>
    <dbReference type="KEGG" id="cge:100755440"/>
    <dbReference type="CTD" id="26273"/>
    <dbReference type="GeneTree" id="ENSGT00940000153571"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22084">
        <property type="entry name" value="F-box_FBXO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1470:FF:000002">
        <property type="entry name" value="F-box only protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003967">
        <property type="entry name" value="PRK05461.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF6">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="ApaG" evidence="9">
        <location>
            <begin position="278"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027278148.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="55026" checksum="B5D248229129865B" modified="2022-01-19" version="1">MAAVEAETAPLTLESLPTDPLLLILSFVDYRDLISCGYVSRRLSQLSTHDPLWRRHCKKYWLISEEEKSRKNQCWKSLFITTYSDVGRYIDHYAAIKKAWDDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEENDDSADMDESDESDEDENESDEGQGEERQRRVFDVPIRRRRCSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MXF7</accession>
    <name>A0A8C2MXF7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Eif2b1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269703.1">
        <property type="nucleotide sequence ID" value="XM_027413902.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MXF7"/>
    <dbReference type="SMR" id="A0A8C2MXF7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028346.1">
        <property type="protein sequence ID" value="ENSCGRP00001024100.1"/>
        <property type="gene ID" value="ENSCGRG00001022107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770460"/>
    <dbReference type="KEGG" id="cge:100770460"/>
    <dbReference type="CTD" id="1967"/>
    <dbReference type="GeneTree" id="ENSGT00550000074853"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000001">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027269703.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33910" checksum="30396B9947354ECD" modified="2022-01-19" version="1">MEDHELIEYFKSQMKGDPNMASAVAAIRTLLEFLKRDKGETLQGLRANLTSAIETLCSVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGARILTHAYSRVVLRVLEEAVAAKKRFSVYITESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSKQTGQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N2V4</accession>
    <name>A0A8C2N2V4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">2-hydroxyacylsphingosine 1-beta-galactosyltransferase</fullName>
            <ecNumber evidence="21">2.4.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Ceramide UDP-galactosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Cerebroside synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">UDP-galactose-ceramide galactosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 31" type="primary">LOC100772408</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:83244"/>
            <dbReference type="ChEBI" id="CHEBI:83246"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:43401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43404"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:83248"/>
            <dbReference type="ChEBI" id="CHEBI:83257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:43405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D-galactosylceramide + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36498"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.4.1.47"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13094"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="20">Sphingolipid metabolism; galactosylceramide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 26">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.47" evidence="21"/>
    <dbReference type="RefSeq" id="XP_035306251.1">
        <property type="nucleotide sequence ID" value="XM_035450360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N2V4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028388.1">
        <property type="protein sequence ID" value="ENSCGRP00001024142.1"/>
        <property type="gene ID" value="ENSCGRG00001022137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772408"/>
    <dbReference type="KEGG" id="cge:100772408"/>
    <dbReference type="GeneTree" id="ENSGT00940000156545"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003851">
        <property type="term" value="F:N-acylsphingosine galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006682">
        <property type="term" value="P:galactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030913">
        <property type="term" value="P:paranodal junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002175">
        <property type="term" value="P:protein localization to paranode region of axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000033">
        <property type="entry name" value="2-hydroxyacylsphingosine 1-beta-galactosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000001">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF54">
        <property type="entry name" value="2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 26" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 26" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00067345"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00076860"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00081606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_035306251.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61105" checksum="F72BB5CC2464F395" modified="2022-01-19" version="1">MKSYTTYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGQLTAVELVDILDHYTKNCDMIVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRIGVSFLVLPKYERIMQKYNLLPSKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLLSWVNGAQEHGFVLVSFGAGVKYLSEDIATKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFFQYFLLDIAFVLLLGAALFYFILSCLIKFIYRKIKSLWSRNKHSTVNGHYQNGIPNGKYKGNGHIKHEKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QEU0</accession>
    <name>A0A8C2QEU0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T cell leukemia, homeobox 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">T-cell leukemia homeobox protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">LOC113837067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027285240.1">
        <property type="nucleotide sequence ID" value="XM_027429439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QEU0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010032.1">
        <property type="protein sequence ID" value="ENSCGRP00001006392.1"/>
        <property type="gene ID" value="ENSCGRG00001008627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113837067"/>
    <dbReference type="KEGG" id="cge:113837067"/>
    <dbReference type="GeneTree" id="ENSGT00940000162452"/>
    <dbReference type="OrthoDB" id="9451579at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050774">
        <property type="term" value="P:negative regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000040">
        <property type="entry name" value="T-cell leukemia homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042247">
        <property type="entry name" value="TLX1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921">
        <property type="entry name" value="IP01054P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921:SF3">
        <property type="entry name" value="T-CELL LEUKEMIA HOMEOBOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027285240.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="30382" checksum="FABB9269C7BE7092" modified="2022-01-19" version="1">MEPAVLAPHHLPHHEPISFGIDQILSGPEPPGGGLGQGQAGQSHGESAAFSGGFHGASGYAPAGSLAPLPRGSGVGPGGVIRVPAHRPLPVPPPSGAAPAVPGPSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QF35</accession>
    <name>A0A8C2QF35_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Progranulin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Acrogranin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Proepithelin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Grn</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the granulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003504550.1">
        <property type="nucleotide sequence ID" value="XM_003504502.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283782.1">
        <property type="nucleotide sequence ID" value="XM_027427981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QF35"/>
    <dbReference type="SMR" id="A0A8C2QF35"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010965.1">
        <property type="protein sequence ID" value="ENSCGRP00001006971.1"/>
        <property type="gene ID" value="ENSCGRG00001009446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756647"/>
    <dbReference type="KEGG" id="cge:100756647"/>
    <dbReference type="CTD" id="2896"/>
    <dbReference type="GeneTree" id="ENSGT00470000042293"/>
    <dbReference type="OrthoDB" id="5854875at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150053">
        <property type="term" value="C:cerebellar climbing fiber to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002265">
        <property type="term" value="P:astrocyte activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001835">
        <property type="term" value="P:blastocyst hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035641">
        <property type="term" value="P:locomotory exploration behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905146">
        <property type="term" value="P:lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099558">
        <property type="term" value="P:maintenance of synapse structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002282">
        <property type="term" value="P:microglial cell activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903979">
        <property type="term" value="P:negative regulation of microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902564">
        <property type="term" value="P:negative regulation of neutrophil activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060266">
        <property type="term" value="P:negative regulation of respiratory burst involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900426">
        <property type="term" value="P:positive regulation of defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106016">
        <property type="term" value="P:positive regulation of inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905673">
        <property type="term" value="P:positive regulation of lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903334">
        <property type="term" value="P:positive regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904075">
        <property type="term" value="P:positive regulation of trophectodermal cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001834">
        <property type="term" value="P:trophectodermal cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.160:FF:000001">
        <property type="entry name" value="Granulin precursor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.160:FF:000004">
        <property type="entry name" value="Granulin precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274:SF3">
        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57277">
        <property type="entry name" value="Granulin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00799">
        <property type="entry name" value="GRANULINS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679239" description="Progranulin" evidence="18">
        <location>
            <begin position="31"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="19">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="19">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="19">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="19">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="19">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="19">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="19">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR639036-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027283782.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="65421" checksum="916E5711B0DF9E93" modified="2022-01-19" version="1">MPPRECGPRSRQTMWTLVSWLAFMAGLVAGTQCPDGQSCPIVCCLDPGGASYSCCNPILDTLPMVMSDRLSGICQVHDHCPGSYSCLLTVSGTSSCCPFPKGISCGDGYHCCPRGFHCSSDGTTCFRHSDSLLRAVQCPGSQFECPESSTCCVMLDGSWGCCPMPQASCCEDKIHCCPHGAFCDMIHTECISPRGTHPLLKKFPAQRKSRAVALHFSVVCPDAQTQCPDDSTCCELPSGKYGCCPMPNAVCCSDHLHCCPQDTVCDLIQSKCLSKKSTTYLLSRLFGNPVPILKEVECDSEVSCPDGYTCCYLTIGSWGCCPFSKAVCCEDHIHCCPEGFHCHTETGTCEMGGLRVPWMKKVKAPLSLLDAEIFQSDVPCDDFTVCPPDNTCCRLSSGGWGCCPIPEAVCCADHQHCCPKGFTCTAEGYCQGGNRMVAVLEKIHPHETFLSQIGDNNCDQHTSCPVGQTCCPSLKGDWACCQLPHAVCCEDRQHCCPTGYICNVKARTCEKAVNSIQIPVHLTLGPQVGEVECGTGHYCHDGQTCCRNSQGGWACCPYLEGTCCADGHHCCPIGFHCSVKGTKCFRRKIPHWDTSLTNPAPRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QIA9</accession>
    <name>A0A8C2QIA9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair and recombination protein RAD54-like</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RAD54 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18 19" type="primary">Rad54l</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19">17A/GY</strain>
            <tissue evidence="18 19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer. Interacts (via N-terminus) with RAD51. Interacts with NAP1L1. Interacts with BRD9; this interaction orchestrates RAD51-RAD54 complex formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_007609240.1">
        <property type="nucleotide sequence ID" value="XM_007611050.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258331.1">
        <property type="nucleotide sequence ID" value="XM_027402530.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295588.1">
        <property type="nucleotide sequence ID" value="XM_035439697.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296482.1">
        <property type="nucleotide sequence ID" value="XM_035440591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QIA9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018001.1">
        <property type="protein sequence ID" value="ENSCGRP00001013764.1"/>
        <property type="gene ID" value="ENSCGRG00001014807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771751"/>
    <dbReference type="KEGG" id="cge:100771751"/>
    <dbReference type="CTD" id="8438"/>
    <dbReference type="GeneTree" id="ENSGT00940000156897"/>
    <dbReference type="OMA" id="YTEHERM"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036310">
        <property type="term" value="F:ATP-dependent DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18067">
        <property type="entry name" value="DEXHc_RAD54A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.850:FF:000002">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="167"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="497"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027258331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035295588.1"/>
        </source>
    </evidence>
    <sequence length="744" mass="84343" checksum="54981F2D468C95E4" modified="2022-01-19" version="1">MRRSLAPSQLARRKPEGRSSDDEDWQPGTVTPKKQKSSNETQCFLSPFRKPLTQLINRPPCLDSSQHEAFIRSILSKPFKVPIPNYQGPLGCRALGLKKAGIRRALHDPLEEGALVLYEPPPLSVHDQLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPECKPEIEKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDRKLEGFMNQRGARVPSPILIISYETFRLHVGVLKKGNVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAQEFKKHFELPILRSRDAAASEADRQLGEERLRELISIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPEEELREGKMSVSSLSSITSLKKLCNHPALIYDKCVSGEDGFEDTLDIFPPGYTSKAVEPQLSGKMLVLDYILAMTRSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFTLDEASLSDTHDRLHCRRCVNRRQVWPPPDGSDCTSDLAQWNHSTDKRGLQDEVLQAAWDASPTAITFVFHHRSHEEQRGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QP51</accession>
    <name>A0A8C2QP51_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UAP56-interacting factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Forty-two-three domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Fyttd1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UIF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007638906.1">
        <property type="nucleotide sequence ID" value="XM_007640716.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268630.1">
        <property type="nucleotide sequence ID" value="XM_027412829.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QP51"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030968.1">
        <property type="protein sequence ID" value="ENSCGRP00001026722.1"/>
        <property type="gene ID" value="ENSCGRG00001023957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763912"/>
    <dbReference type="KEGG" id="cge:100763912"/>
    <dbReference type="CTD" id="84248"/>
    <dbReference type="GeneTree" id="ENSGT00390000012807"/>
    <dbReference type="OrthoDB" id="9938627at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009782">
        <property type="entry name" value="FYTTD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21038">
        <property type="entry name" value="40-2-3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21038:SF2">
        <property type="entry name" value="UAP56-INTERACTING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07078">
        <property type="entry name" value="FYTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027268630.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35765" checksum="5998981AD65AB34D" modified="2022-01-19" version="1">MNRFGTRLVGATATPPPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLQQSGTRQFRMRVRWGIQQNSGFGKTSVSRRGRVLPGKRRPYGVITGLAARKATGIRKGISPMNRPPLSDKNIERYFPALKRKTSLLRQNEVQRKPVAVLKRPNQLNRKNNIPANFTRSGNKLSHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVPQKPRLARTAVPSFLTKREQSDVKKVPKGVPLQFDINSVGKQTGMTLNERFGILKEQRATLTFNKGGSRFVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZP2</accession>
    <name>A0A9J7EZP2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleophosmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100760757</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoplasmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027247424.1">
        <property type="nucleotide sequence ID" value="XM_027391623.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EZP2"/>
    <dbReference type="GeneID" id="100760757"/>
    <dbReference type="KEGG" id="cge:100760757"/>
    <dbReference type="OrthoDB" id="9946910at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2100:FF:000001">
        <property type="entry name" value="Nucleophosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032569">
        <property type="entry name" value="NPM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004301">
        <property type="entry name" value="Nucleoplasmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024057">
        <property type="entry name" value="Nucleoplasmin_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747:SF28">
        <property type="entry name" value="NUCLEOPHOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747">
        <property type="entry name" value="NUCLEOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16276">
        <property type="entry name" value="NPM1-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03066">
        <property type="entry name" value="Nucleoplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nucleoplasmin core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleophosmin C-terminal" evidence="13">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027247424.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25700" checksum="3390BC31331FEA3A" modified="2023-06-28" version="1">MVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLWLRGGSGPVHISGQHLVPVEEDAESEDEDEEGVKLLSMSGKRSAPGGSSKVPQKKVKIDEDEDDDDFDDEETEEKVPVKKFVRDTPAKNAQKSNQNGKDLKLSTPRSKGQESFKKQEKTPKTTKGPSSVEDIKAKMQASIGKGSSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZR6</accession>
    <name>A0A9J7EZR6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TNFAIP3-interacting protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">A20-binding inhibitor of NF-kappa-B activation 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">Tnip2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23">17A/GY</strain>
            <tissue evidence="22 23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027242972.1">
        <property type="nucleotide sequence ID" value="XM_027387171.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309167.1">
        <property type="nucleotide sequence ID" value="XM_035453276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EZR6"/>
    <dbReference type="GeneID" id="100769313"/>
    <dbReference type="KEGG" id="cge:100769313"/>
    <dbReference type="CTD" id="79155"/>
    <dbReference type="OrthoDB" id="6066489at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034134">
        <property type="term" value="P:toll-like receptor 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034138">
        <property type="term" value="P:toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.990:FF:000005">
        <property type="entry name" value="TNFAIP3 interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022008">
        <property type="entry name" value="EABR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034735">
        <property type="entry name" value="NEMO_ZF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882:SF6">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12180">
        <property type="entry name" value="EABR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51801">
        <property type="entry name" value="ZF_CCHC_NOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC NOA-type" evidence="20">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="259"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027242972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035309167.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49372" checksum="B4E99B71688CAB04" modified="2023-06-28" version="1">MSSGDARTGRQDGAPRAAAALCSLYHEAGQQLQRLQDQLAARDALIASLRTRLEALEGDTAPSLVDALLDQVERFREQLRRQEEGATETQLRQEVERLTERLEEKEREMQQLMSQPQHEREKEVVLLRRSVAEKEQARAASDILCRSLADETHQLRRTLAATAHMCQHLARCLDERQHAQGDVGEGSPNELRHTSRNASGKSVIEKLQEENRLLKQKVTHVEDLNAKWQRYDASRDEYVKGLHAQLKRRQVPHEPELMKKEISRLNRQLEEKINDCAEAKQELATVKMARDTALERVQMLEQQILAYKDDFKSERADRERAHSRIQELEEKVFSLMSQASQRQQDFQEPGPCWIHSAKKTAKYLEMDALEHVAPGSWRTALGSQQVELPAEGGHVHTAHRGQGDLQCPHCLRCFSDEQGEAFLRHLSECCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F261</accession>
    <name>A0A9J7F261_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: sentan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Sntn</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the S-100 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027245155.2">
        <property type="nucleotide sequence ID" value="XM_027389354.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293255.2">
        <property type="nucleotide sequence ID" value="XM_027437454.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100754229"/>
    <dbReference type="KEGG" id="cge:100754229"/>
    <dbReference type="CTD" id="132203"/>
    <dbReference type="OrthoDB" id="9362863at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00213">
        <property type="entry name" value="S-100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="S-100_dom"/>
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        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF134">
        <property type="entry name" value="PROTEIN S100-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S100/CaBP-9k-type calcium binding subdomain" evidence="3">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027245155.2"/>
        </source>
    </evidence>
    <sequence length="148" mass="16310" checksum="DC08DA3CD5C6C2D7" modified="2023-06-28" version="1">MKSTAGCMHSTQDHTIHXGGEPRLSEAPASTXTPSKMPKSVSISKQLASIKALKKGSDLEKAIATIALIFRNSSDPDGKLGKTTAKNLLQTQFRNFTEREETKPKCQDILSELDEHTENKLDFEDFMILLLSLAIVSDMLQDILSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F3P4</accession>
    <name>A0A9J7F3P4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Membrane-associated guanylate kinase inverted 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Magi3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003505872.3">
        <property type="nucleotide sequence ID" value="XM_003505824.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249647.1">
        <property type="nucleotide sequence ID" value="XM_027393846.2"/>
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    <dbReference type="GeneID" id="100763218"/>
    <dbReference type="KEGG" id="cge:100763218"/>
    <dbReference type="CTD" id="260425"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PDZ0_MAGI-1_3-like"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="CDD" id="cd06733">
        <property type="entry name" value="PDZ3_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ4_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06735">
        <property type="entry name" value="PDZ5_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000005">
        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="FunFam" id="2.20.70.10:FF:000002">
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        <property type="entry name" value="membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
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        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF10">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0796">Tight junction</keyword>
    <keyword evidence="22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="19">
        <location>
            <begin position="116"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="413"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="581"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="729"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="851"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="1021"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1165"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1193"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1231"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1284"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1319"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1343"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1356"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1392"/>
            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027249647.1"/>
        </source>
    </evidence>
    <sequence length="1462" mass="160203" checksum="676160ABE949DD09" modified="2023-06-28" version="1">MSKTLKKKKHWLSKVQECAVSWAGPPGDLGAEIRGGAERGEFPYLGRLRDEPGGGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGNTETREMHSESSDCWMKTVPSYNQTNSSMDFRNYMMRDENLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQIGQAEIHSAKPDVERSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNTQDFKPGAMALDQNGKPSQILASDRLNGPSDSSEQRASLASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPRSPTKTAKMKTDAKENSGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSPQTFTQNGSPRLNRAELPARPAQEAYDVILQRKENEGFGFVILTSKSKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQAQANHIPGDRIALEGEIGKEICSSYRHSWSDHKHVAQSDTAVISVVGSRHNQGLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINSPSSSNVIYDEQPPLLPSSHSASVFEESHMPVTEDSLIRVQICEKAEELKDTVPEKKSTFSGSQPEMKHQTVLQKNVSKKDPPSSQRHGEKNLLKGENGVTRRERSASPKKSANQHSEEHLEKIPRPLKSDPKGKSRDRSLSPRKGETKGQITTKAGSGQDPCRKGRGRSSSPKNQQKIVGTGPSNTESQRAAGHTSDSTEQLPDGKEKSGVVRKDLKQSQLGKTRTRSPEKKSNKVDETSLPSKKISNTASRAVSEKEKGKKPTTGENVQISAKKLKQEPEEKMTLGKAEDHKGKEPEATDRCKERAGGIPENSSPVKKAPITPGPWRVPRANKIIGPAGMADKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F631</accession>
    <name>A0A9J7F631_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ataxin-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Atxn10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027251977.1">
        <property type="nucleotide sequence ID" value="XM_027396176.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F631"/>
    <dbReference type="GeneID" id="100756095"/>
    <dbReference type="KEGG" id="cge:100756095"/>
    <dbReference type="CTD" id="25814"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="370"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="459"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027251977.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59225" checksum="76598C81041BF76A" modified="2023-06-28" version="1">MAAPRMPPSRLSGVMVPAPIQDLEALRALTALFKEYRNRETAPRTIFQRVLDILKKSTHAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFMSCLNHPDKKIVAYCSMILFTSLNPERMKDLEENLNIAINVIEAHQKHPESEWPFLIITDHFLKSPELVEAMYSKLSNQERVTLLDIMIAKLVGDEQLTKDDISIFLRHAELIANSFVDQCRNVLKLTSEPHTEDKEALATIRLLDVLCEMTSNTELLGYLQVFPGLMERVIDVLRVIHVTGKDTSNIFSPSDSLKAEGDIEHMAEGFKSHLIRLIGNLCYKNKENQDKVNELDGIPLILDSSNIDDNNPCILEYDPQPENLISLWLKTQFFILFAGGHSCELQKWGSMLLNSFTLAPVMMQWVVYAVRNLTEDNSQNQDFIAKMEEQGLADASLLKKMGFEVEKSGEKLILKSNNDIPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FBE9</accession>
    <name>A0A9J7FBE9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Zinc finger protein Helios isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Ikzf2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027252941.1">
        <property type="nucleotide sequence ID" value="XM_027397140.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027291280.1">
        <property type="nucleotide sequence ID" value="XM_027435479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FBE9"/>
    <dbReference type="GeneID" id="100760184"/>
    <dbReference type="KEGG" id="cge:100760184"/>
    <dbReference type="CTD" id="22807"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000073">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000525">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000124">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000372">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000168">
        <property type="entry name" value="zinc finger protein Eos isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF33">
        <property type="entry name" value="ZINC FINGER PROTEIN HELIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
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        <location>
            <begin position="156"/>
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            <begin position="212"/>
            <end position="240"/>
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            <begin position="44"/>
            <end position="105"/>
        </location>
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            <begin position="384"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027252941.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61269" checksum="0092B5312F6B20B1" modified="2023-06-28" version="1">MFFNQRTISFHCTLTMETEAIDGYLTSGDNELSPEGEHANMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQDLQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTANMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHAPSTIAEVAPVISSAYSQVYHPNRIERPISRETSDSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGNPALNPKRKQSPAYMKEDVKALDATKATKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FG95</accession>
    <name>A0A9J7FG95_CRIGR</name>
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        <submittedName>
            <fullName evidence="18">LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 38-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC113833884</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027399976.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FG95"/>
    <dbReference type="GeneID" id="113833884"/>
    <dbReference type="KEGG" id="cge:113833884"/>
    <dbReference type="OrthoDB" id="5954366at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Leucine rich repeat containing 38"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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    </dbReference>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR000372">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF213">
        <property type="entry name" value="INSULIN LIKE GROWTH FACTOR BINDING PROTEIN ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="16">
        <location>
            <begin position="353"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027255777.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="49031" checksum="6112F4FDA51A8EF8" modified="2023-06-28" version="1">MGLDSLGHCPGVGAKVTRVLLADMRVALRAHAPDTPYANRSRDRSPNLVLSTAGQVRATGPTSPPEWGRAGLAPRSLPMPWNVPEGQFPVPVNSAPSASPLPPPSLLPGHPRSLCPRHTLIAPARPGAASLPRAAALGRPEPGSQGPAAPTAPRAVSARVPGAMSLCAVPRRPTGAAAALGLGSLLMLLGPGRACPEGCACTDPHTVDCSDRGLPSVPDPFPLDVRKLLVAGNRIQQIPEDFFIFHGDLVYLDFRNNSLRSLEEGTFSGSAKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSLNVATLDALPALRTVRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDAIQCSLPMEDRRVALRELSEASFSECKFSLSLTDLFIIIFSGVAVSIAAIISSFFLATVVQCFQRCAPNKDTEDEDDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FHG1</accession>
    <name>A0A9J7FHG1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Interleukin-20 receptor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Il20ra</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type II cytokine receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007649376.1">
        <property type="nucleotide sequence ID" value="XM_007651186.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257684.1">
        <property type="nucleotide sequence ID" value="XM_027401883.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FHG1"/>
    <dbReference type="GeneID" id="100751800"/>
    <dbReference type="KEGG" id="cge:100751800"/>
    <dbReference type="CTD" id="53832"/>
    <dbReference type="OrthoDB" id="9909056at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042015">
        <property type="term" value="F:interleukin-20 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000348">
        <property type="entry name" value="Interleukin 20 receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF86">
        <property type="entry name" value="INTERLEUKIN-20 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon/interleukin receptor" evidence="7">
        <location>
            <begin position="86"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027257684.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56069" checksum="9DCA450B98DC8E4A" modified="2023-06-28" version="1">MKNVLHWNPPEGLRGVEVTYTVQYFIYGQKQWLGASECRSISRTYCDLSAETSDYEHQYYAKVKAMQETKCSEWAETRRFYPFLETQVGPPEVALTPGEKSISIDLTAPKKWQRNPKDDTVSMQQIYSNLKYNVFVYNTKSRRMWSKCITNSTLELRWLEPSTLYCVHVESFVPGLPRLTLPSQKQCISTLEDEMSALKVKVIFWYVLPTSVIVFLFSVMGYSVYRYIHVGKEKHPSNLILIYGNEIKRFFEPTETITLNFITLNMMDDSKISQKDMSLLEQSSDSSCLNDPELSGSWHPHLEEVEGPCLGYSLPLMDTVSDAEQSNSNVCLSQHEWLIVPTGVSDNDPEYTVPADLYGEAEDHQLCGQEEASTTETLSEPQAALANLGPSLVGLYHLGERHPASEEGPEEEPSATLVDWDPQTGRLCIPSFPSFGQDPVDYGHYERDQLSEDGLLSRLYKNEAADKSEDENENYLVQFMQEWRLHVQIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FHX9</accession>
    <name>A0A9J7FHX9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuronal pentraxin receptor isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Nptxr</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027259572.1">
        <property type="nucleotide sequence ID" value="XM_027403771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FHX9"/>
    <dbReference type="GeneID" id="100750799"/>
    <dbReference type="KEGG" id="cge:100750799"/>
    <dbReference type="CTD" id="23467"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00152">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000012">
        <property type="entry name" value="neuronal pentraxin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF94">
        <property type="entry name" value="NEURONAL PENTRAXIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="9">
        <location>
            <begin position="419"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027259572.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="66586" checksum="EDC7CEFFB507F063" modified="2023-06-28" version="1">MSDFASKDLKLGLQLGMLPVSHDAWAGFQVTNSYPLIRLWVFMMSRPCIDEVLGVAHAPGLPARNGCGVGPRPAPGERVGRGRRARLLLLPPPGLRAAAAAAAATSPVLAPAPALPGPAPRPRRRSCRGPSAPPPRFTLKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGTDNASAAGAPGPQRSLSALHGAGGSAGPSALPGEPAASVFPPPPGPLLSRFLCTPLAAACPSGTEQGDAAGERAELLLLQSTAEQLRQTALQQEARIRADRDTIRELTGKLGRCESGLPRGLQDAGPRRDTMADGAWDSPALLLELEDAVRALRDRIERIEQELPVRGNLSAPAPAVPTALHTKMDELEGQLLAKVLALEKERAALSHGSHQQRQEVEKELDALQGRVAELEHGSSAYSPPDAFRVSIPIRNNYMYARVRKALPELYAFTACMWLRSRSGGSGQGTPFSYSVPGQANEIVLLEAGLEPMELLINDKVAQLPLSLKDNNWHHICIVWTTRDGLWSAYQDGELRGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHVLTPAQVLGMANCTGPLMGNVLPWEDKLVETFGGAKKSTFDVCKGRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FK20</accession>
    <name>A0A9J7FK20_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain-containing protein KCTD17 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Kctd17</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_016818940.1">
        <property type="nucleotide sequence ID" value="XM_016963451.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259736.1">
        <property type="nucleotide sequence ID" value="XM_027403935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FK20"/>
    <dbReference type="GeneID" id="100763063"/>
    <dbReference type="KEGG" id="cge:100763063"/>
    <dbReference type="CTD" id="79734"/>
    <dbReference type="OrthoDB" id="1244179at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18391">
        <property type="entry name" value="BTB_POZ_KCTD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2000:FF:000001">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000005">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958:SF24">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027259736.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40679" checksum="F6D2E7D7115DC0B4" modified="2023-06-28" version="1">MQTPQLAMRMEAGEAAPPAGAGGRAGGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEFLCVVSKELHSSPHGLSSESSRKTKSTDEQLEEQRRQEVEEVEVAQVQVEADAQEKAITSQRHPDVSPQITSRDLGFRSEILYFCTTGWAPGPRRKTCPLPYHCCLHLLGWDSTLPPGPGLGPSGTLEGLRWALVCPGRVICPWPKCGTAHPYLPGPFVPSPGPPCCMADPLPPSPVIAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FK97</accession>
    <name>A0A9J7FK97_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Beta-1,3-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.222</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Mfng</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70511"/>
            <dbReference type="Rhea" id="RHEA-COMP:17919"/>
            <dbReference type="Rhea" id="RHEA-COMP:17920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="ChEBI" id="CHEBI:189633"/>
            <dbReference type="EC" id="2.4.1.222"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70531"/>
            <dbReference type="Rhea" id="RHEA-COMP:17922"/>
            <dbReference type="Rhea" id="RHEA-COMP:17923"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="ChEBI" id="CHEBI:189634"/>
            <dbReference type="EC" id="2.4.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 21">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.222" evidence="18"/>
    <dbReference type="RefSeq" id="XP_027259760.1">
        <property type="nucleotide sequence ID" value="XM_027403959.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FK97"/>
    <dbReference type="GeneID" id="100762875"/>
    <dbReference type="KEGG" id="cge:100762875"/>
    <dbReference type="CTD" id="4242"/>
    <dbReference type="OrthoDB" id="8959630at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033829">
        <property type="term" value="F:O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000003">
        <property type="entry name" value="Beta-1,3-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017374">
        <property type="entry name" value="Fringe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038073">
        <property type="entry name" value="B-acetylgalactosaminyltfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18 21" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="22">
        <location>
            <begin position="51"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038073-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038073-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038073-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027259760.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36163" checksum="F545371DFFA46167" modified="2023-06-28" version="1">MHCRAFRSLAGALFTLLCVGLLSLRYHSSLSLWMAQDSFRLNQPNPGSLELQLGDIFIAVKTTWAFHRSRLDLLLDTWVSRTRQQTFIFTDSPDENLQERLGSHLVVTNCSAEHSHPALSCKMAAEFDAFLASGLRWFCHVDDDNYVNPRALLQLLKTFPQDRDVYVGKPSLNRPIHASELQSKNRTRLVQFWFATGGAGFCISRQLALKMVPWASGSHFVDTSALIRLPDDCTVGYIIECKLGGHLQPSPLFHSHLETLQLLGAAQLLEQVTLSYGVFEGKLNIIKLQGPFSHEEDPSRFRSLHCLLYPDTPWCPLVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FL63</accession>
    <name>A0A9J7FL63_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100764719</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007642939.1">
        <property type="nucleotide sequence ID" value="XM_007644749.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259404.1">
        <property type="nucleotide sequence ID" value="XM_027403603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FL63"/>
    <dbReference type="GeneID" id="100764719"/>
    <dbReference type="KEGG" id="cge:100764719"/>
    <dbReference type="OrthoDB" id="6144223at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15430">
        <property type="entry name" value="7tmA_OR13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000501">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027259404.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35421" checksum="EC2148FF4180EE85" modified="2023-06-28" version="1">MDENNQTFVSGFLLWGLSGYPKTEIIYFALILAMYLVILTGNGVLIIASIFDARLHTPMYFFLGNLSFLDICYTTSSVPSTLVSLISKKRNISFSGCTVQMFFGLAMGSTECFLLGMMAFDRYVAIYNPLRYSVIMSKGVYVSMASVSWFSGGINSVVQTSLTMRLPFCGNKVINGFTCEVLPVLKLACADISLNIITMMISNMAFLVLPLLVIFFSYMFILHTILRMNSATGRRKAFSTCSAHLTVVVIFYGTVFSMYAKPKSQDLTGEDNFQTSDKIISLFYGVVTPMLNPIIYSLRNKDVKAAVKYILKQKYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FN06</accession>
    <name>A0A9J7FN06_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Chst6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_027261857.1">
        <property type="nucleotide sequence ID" value="XM_027406056.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FN06"/>
    <dbReference type="GeneID" id="100770004"/>
    <dbReference type="KEGG" id="cge:100770004"/>
    <dbReference type="CTD" id="4166"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018146">
        <property type="term" value="P:keratan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000703">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF4">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039928502" description="Sulfotransferase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="13">
        <location>
            <begin position="43"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027261857.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44802" checksum="E61E42ED6B11482C" modified="2023-06-28" version="1">MRLPRFSSAFVLSLLIVQTCILVFLVSRQTPSSPTAGNRERVHVLVLSSWRSGSSFLGQVFSQHPDVFYLMEPAWHVWDALSQGSAPTLHMAVRDLVRSVFLCDMDVFDAYLPWRRNISDLFQWAVSRALCSPPACNAYARRSISSEEVCKSLCATRPFSLARESCSSYSHVVLKEVRFFNLQVLYPLLSDPALNLHIVHLVRDPRAVLRSREQAAKALARDNGIILGTNGTWVEADPRLRVVSEVCRSHVRIAEAALHKPPPFLQDRYRLVRYEDLVRDPLTQIRELYAFTGLNLTQKLQTWIHNITHGSGPGSHREAFKTSSRDALSVSQAWRLTLPFDKIQQVQELCAGALQLLGYRPVHSELEQRDLSLDLLLPRGMDKFKWASSTDAQPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FPD5</accession>
    <name>A0A9J7FPD5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Sphingomyelin phosphodiesterase 3</fullName>
            <ecNumber evidence="6">3.1.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Neutral sphingomyelinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Neutral sphingomyelinase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">Smpd3</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
            <tissue evidence="36">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74001"/>
            <dbReference type="ChEBI" id="CHEBI:75216"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:39924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:75542"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine + H2O = N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74450"/>
            <dbReference type="ChEBI" id="CHEBI:74535"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:45321"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine + H2O = N-hexadecanoylsphing-4-enine + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
            <dbReference type="ChEBI" id="CHEBI:78646"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:45645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine + H2O = N-tetracosanoyl-sphing-4-enine + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72965"/>
            <dbReference type="ChEBI" id="CHEBI:83360"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:45325"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a sphingosylphosphocholine + H2O = a sphingoid base + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:84410"/>
            <dbReference type="ChEBI" id="CHEBI:85171"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:45297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45300"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64583"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:45301"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Golgi apparatus membrane</location>
            <topology evidence="20">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_027261718.1">
        <property type="nucleotide sequence ID" value="XM_027405917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FPD5"/>
    <dbReference type="GeneID" id="100755276"/>
    <dbReference type="KEGG" id="cge:100755276"/>
    <dbReference type="CTD" id="55512"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006684">
        <property type="term" value="P:sphingomyelin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09078">
        <property type="entry name" value="nSMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000015">
        <property type="entry name" value="sphingomyelin phosphodiesterase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017766">
        <property type="entry name" value="Sphingomyelinase/PLipase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF8">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="33" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="34">
        <location>
            <begin position="336"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="209"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00050994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00068544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00076605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00081703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_027261718.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="71198" checksum="3AEB8235FFFD9DA1" modified="2023-06-28" version="1">MVLYTTPFPNSCLSALHAVSWALIFPCYWLVDRLVASFIPTTYEKRQRADDPCCLQLFCTVLFTPVYLALFVAALPFAFLGFIFWSPLQSARRPYSYSRLEDKSPAGGAALLSEWKGTGAGKSFCFATANVCLLPDSLARLNNVFNTQARAKEIGQRIRNGAARPQIKIYIDSPTNTSISAASFSSLVSPQGSDGARAVPGSIKRTASVEYKGDGGRHPSEEAANGPASGDPADGSLEDSCIVRIGGDEGGRPPEADDPATGSQARNGAGGVPKGQTPNHNQRDGDSGSLGSPSASRESLVKARAGQDGGGSGEPGVNSKLLYKTSVVKKTAARRRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAAAKLKEQLHGYFEYILYDVGVYGCHGCCNFKCLNSGLFFASRYPVMDVAYHCYPNGCSFDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPPEDSAIRCEQLDLLQDWLADFRKSTSSSSTANPEELVVFDIICGDLNFDNCSSDDKLEQQHSLFTRYKDPCRLGPGEEKPWAIGTLLDTNGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSPGAGQKGRKDLLKGNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSAGEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FPZ6</accession>
    <name>A0A9J7FPZ6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cathepsin 7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100753281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027265827.1">
        <property type="nucleotide sequence ID" value="XM_027410026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FPZ6"/>
    <dbReference type="GeneID" id="100753281"/>
    <dbReference type="KEGG" id="cge:100753281"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039949722" evidence="8">
        <location>
            <begin position="18"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="10">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="114"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027265827.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37740" checksum="3C71DE5C1BFDB594" modified="2023-06-28" version="1">MILAVLLGFLYLGVASAAPTPDYSLDAEWEEWKRSYDKTYSQEEERQKRAVWEENVKMIKLLSMETGLGMNNFTVEMNEFGDLTGEEMRKMMTDSSVLTLRNGKHIQKRGDVKIPKTLDWRTQGYVGPVRRQNGCGACWAFALAGSIEGQMFKKTGKMTQLSVQNLIDCSRTYGTNGCKGGRLYNAFQYVKNNGGLEAEATYPYEAKVRRCRYRAERSVVKITRFLVVPRNEEALMNALVTHGPIAVGIDAGHESFTNYAGGMYHEPNCRRDSPTHSVLLVGFGYEGRESEGRKYWLIKNSHGENWGENGYMKIPRDQNNYCGIASYAMYPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FUZ2</accession>
    <name>A0A9J7FUZ2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Keratin-associated protein 20-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100754931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts with hair keratins.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269083.1">
        <property type="nucleotide sequence ID" value="XM_027413282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FUZ2"/>
    <dbReference type="GeneID" id="100754931"/>
    <dbReference type="KEGG" id="cge:100754931"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052878">
        <property type="entry name" value="KRTAP_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021743">
        <property type="entry name" value="KRTAP_type8/19/20/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39653">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 20-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39653:SF6">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 20-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11759">
        <property type="entry name" value="KRTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0416">Keratin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027269083.1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6327" checksum="AEC8F0DA1B87B024" modified="2023-06-28" version="1">MCYYSSYYGGLGYGYGGLGYGYGCGYGGYGCGYGGYGGYGYGCCRPLCCRRYWSYGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FVH7</accession>
    <name>A0A9J7FVH7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Cleavage and polyadenylation specificity factor subunit 4</fullName>
            <shortName evidence="15">CPSF 30 kDa subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Cleavage and polyadenylation specificity factor 30 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Cpsf4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 15">Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007648507.1">
        <property type="nucleotide sequence ID" value="XM_007650317.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269423.1">
        <property type="nucleotide sequence ID" value="XM_027413622.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FVH7"/>
    <dbReference type="SMR" id="A0A9J7FVH7"/>
    <dbReference type="GeneID" id="100773929"/>
    <dbReference type="KEGG" id="cge:100773929"/>
    <dbReference type="CTD" id="10898"/>
    <dbReference type="OMA" id="EEVTCFK"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000005">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4 isoform X2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
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    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF18">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057634"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00064473"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00075609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027269423.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30255" checksum="525EFF8F12F1ECFA" modified="2023-06-28" version="1">MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPTKQSNNPPLQRSSSLIQLTSQNSSPNQQRAPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FW36</accession>
    <name>A0A9J7FW36_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Mannan-binding lectin serine protease 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Complement factor MASP-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Complement-activating component of Ra-reactive factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Mannose-binding lectin-associated serine protease 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Mannose-binding protein-associated serine protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Ra-reactive factor serine protease p100</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Serine protease 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="primary">Masp1</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="39" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="40" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="40">17A/GY</strain>
            <tissue evidence="40">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1. Interacts with COLEC11; probably triggers the lectin pathway of complement.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="30">The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003495652.1">
        <property type="nucleotide sequence ID" value="XM_003495604.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268771.1">
        <property type="nucleotide sequence ID" value="XM_027412970.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FW36"/>
    <dbReference type="GeneID" id="100774526"/>
    <dbReference type="KEGG" id="cge:100774526"/>
    <dbReference type="CTD" id="5648"/>
    <dbReference type="OrthoDB" id="9985152at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000015">
        <property type="entry name" value="Atrial natriuretic peptide-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000059">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000016">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000006">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000012">
        <property type="entry name" value="mannan-binding lectin serine protease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000028">
        <property type="entry name" value="mannan-binding lectin serine protease 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024175">
        <property type="entry name" value="Pept_S1A_C1r/C1S/mannan-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF13">
        <property type="entry name" value="MANNAN-BINDING LECTIN SERINE PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
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<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">17A/GY</strain>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">17A/GY</strain>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
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    </reference>
    <comment type="function">
        <text evidence="6">Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA.</text>
    </comment>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276836.1">
        <property type="nucleotide sequence ID" value="XM_027421035.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G7I5"/>
    <dbReference type="GeneID" id="100765781"/>
    <dbReference type="KEGG" id="cge:100765781"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027276836.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19213" checksum="8280117846202B19" modified="2023-06-28" version="1">MFYHISLEHEILLHPCYFGPNLLNTVKQKLFTEVEGTCKGKYDFVIAVTTIDNIGAGEIQPGQGFDLHTVKFKAIVFQPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMGEDIVIHQDDEIRLKIVGTRVDKNDIFAIGSPMDDYLGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GDA9</accession>
    <name>A0A9J7GDA9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Suppressor of cytokine signaling 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Socs7</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Substrate-recognition component of the ECS(SOCS7) complex, composed of SOCS7, CUL5, ELOB, ELOC and RNF7/RBX2. Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6. Interacts with phosphorylated IRS4 and PIK3R1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027279969.2">
        <property type="nucleotide sequence ID" value="XM_027424168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GDA9"/>
    <dbReference type="GeneID" id="100763757"/>
    <dbReference type="KEGG" id="cge:100763757"/>
    <dbReference type="CTD" id="30837"/>
    <dbReference type="OrthoDB" id="5979828at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10388">
        <property type="entry name" value="SH2_SOCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03741">
        <property type="entry name" value="SOCS_SOCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000029">
        <property type="entry name" value="Suppressor of cytokine signaling 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035866">
        <property type="entry name" value="SOCS7_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037346">
        <property type="entry name" value="SOCS7_SOCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF5">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="8" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="440"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="19">
        <location>
            <begin position="544"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="125"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027279969.2"/>
        </source>
    </evidence>
    <sequence length="621" mass="67161" checksum="F1717FE0061A2744" modified="2023-06-28" version="1">MERRPPSQARRRRAAAAPGHGPSPPPFLARPGPRGARPPQLMVFRNVGRPPEEEDAEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPVSGLEAQLAALGLGQPAGPGVKTAGGGCCPCPCPCPPQPPPPQPPPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPPGRLSRGEYQPQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGDLAASAASLTDMGGSAGRELDAGRKPRLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRASESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GEI5</accession>
    <name>A0A9J7GEI5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: mastermind-like protein 1 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100768930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mastermind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283446.2">
        <property type="nucleotide sequence ID" value="XM_027427645.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GEI5"/>
    <dbReference type="GeneID" id="100768930"/>
    <dbReference type="KEGG" id="cge:100768930"/>
    <dbReference type="OrthoDB" id="5982619at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007221">
        <property type="term" value="P:positive regulation of transcription of Notch receptor target"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046369">
        <property type="entry name" value="MAML1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048455">
        <property type="entry name" value="MAML1_3_TAD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046370">
        <property type="entry name" value="MAML_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019082">
        <property type="entry name" value="Mastermind-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15692">
        <property type="entry name" value="MASTERMIND-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15692:SF19">
        <property type="entry name" value="MASTERMIND-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09596">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20801">
        <property type="entry name" value="MAML1_3_TAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01275">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Neurogenic mastermind-like N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="770"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="889"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027283446.2"/>
        </source>
    </evidence>
    <sequence length="1022" mass="108265" checksum="E5DEA9D0384F2C0B" modified="2023-06-28" version="1">MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAAAAPRPRSAPAPAPAPAAARLEAADGPEHGRPVAHLHDTVKRNLDSAASPQNGDQQNGYGDLFPGHKKTRREAPLGISVSANGLPPASPLGQPDKPPGGDALQSGGKHSLGLDPINKKCMADSSIHLNGSSNPNEPFPLSLSKELKQEPVDDLPCMIAGAGGSVSQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFTEDFEEKKDPEPPGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVGTDSPSLGSSQTLFHTTGQPGADNPSPNLMPASAQAQNAQRALASVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQAASAPAPGQLSTWQQAGPSHSPLDVPYPMEKPASPPGYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHSNLLSHQSPSNLNQSSVNNQGAVLDYGNTKPLSHYKADCGQGGPGSGQSKPALMAYLPQQLPHLSNEQNSLFLMKQKAANMPFRSLVPPGQEQNPSNVSVPAQTANVGTQPPSVSVASTHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQLQQQQQQFLQRQHLLAEQEKQQFQRHLTRPPPQYQDPTQSTFPQQVGQFPGPSAAVPGMNNLGPSNSSCPRVFPQPGTLMSMGPGHAPVSSLPSSSGPQDRGVAQFTGSQSLPQSSLYGITSGLPQIVAQPPPQAASAHAHIPRQTSVGQNASAPAAYGQNSLGSAGLSQQHNKGTLPPGLTKSQVPRVSAAMGGQNASWQHQGMPNLSSQTPGNSSVSPFAAPSSFHMQQAHLKIPGQQFSQAMPSRPMAPMSSAGAAGSMLPPVSTQQRNSAPAPAPPQAAPQQGLPGLSPAGPELGAFSQSSTSQMNSRAGLHCTQAYPVRTMGQELPFAFSGQPGSSGLSSVAGHTDLIDSLLKNRTSEEWINELDDLLGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GIM2</accession>
    <name>A0A9J7GIM2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch-like protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Klhl11</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283957.1">
        <property type="nucleotide sequence ID" value="XM_027428156.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GIM2"/>
    <dbReference type="GeneID" id="100750471"/>
    <dbReference type="KEGG" id="cge:100750471"/>
    <dbReference type="CTD" id="55175"/>
    <dbReference type="OrthoDB" id="9978265at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd18451">
        <property type="entry name" value="BACK_KLHL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18241">
        <property type="entry name" value="BTB_POZ_KLHL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000019">
        <property type="entry name" value="Kelch-like 11 (Drosophila) (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000153">
        <property type="entry name" value="Kelch-like 11 (Drosophila), isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KELCH-LIKE PROTEIN 11"/>
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    <dbReference type="Pfam" id="PF13964">
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
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        <property type="entry name" value="BTB"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055311"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00069978"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="708" mass="80163" checksum="7121B12AB1ABAF1C" modified="2023-06-28" version="1">MAAAVAAGGAAAAAAASLQVLEMESMETAAAGSAGLAAEVRGSGTVDFGPGPGISAMEASGGDPGPEAEDFECRTHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFYKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVADAVERHALRAENLQSGTLQHPASHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWKDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYSLENEEAVRKIAGQVSDEILESLPPEVLSIEGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVRIPYRYLHGTQRYPMPQNLMWQKDRIRQMQEIHRHALNMRRVPSSQIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GLU4</accession>
    <name>A0A9J7GLU4_CRIGR</name>
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        <submittedName>
            <fullName evidence="8">A-kinase anchor protein 9-like</fullName>
        </submittedName>
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        <name evidence="8" type="primary">LOC113838191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027289814.2">
        <property type="nucleotide sequence ID" value="XM_027434013.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GLU4"/>
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    <dbReference type="KEGG" id="cge:113838191"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:synaptic membrane"/>
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    </dbReference>
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        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027289814.2"/>
        </source>
    </evidence>
    <sequence length="279" mass="31082" checksum="94475BC237320E26" modified="2023-06-28" version="1">MAAAMAGPVGKAGAAGERLARPGRPRSSVCWPLNRSFCSPSPRLAGRRDGGGGEMEEDRVWQGQGKRISLDSSHSEQAAHCSLTHVEMTENDLAGKQHEIEELTQWLEGMRATCGTEVLQRLPLPPGALSYEFVAAIKKQDSIITCLAAHMQQSRKETDQILEEFFQLTERSEKVQFQDQHASETLQSSTHRSAAAELVLLKQQVPDQKQVLEQQYHLLNDYQKKEEELTNEVTSLQEKLKVCEMGTEFPTAMECLQKADKRSVLPLNALNNGREEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GM02</accession>
    <name>A0A9J7GM02_CRIGR</name>
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        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: RCC1 and BTB domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100753934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035294974.1">
        <property type="nucleotide sequence ID" value="XM_035439083.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312911.1">
        <property type="nucleotide sequence ID" value="XM_035457020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753934"/>
    <dbReference type="KEGG" id="cge:100753934"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
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        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF4">
        <property type="entry name" value="RCC1 AND BTB DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
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    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="369"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035294974.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="57455" checksum="37AA65990A6A48B1" modified="2023-06-28" version="1">MVDVGKWPILTLLSPQETASIRKACVFGTSANEAIYVTDNDKVFMFGLNYSNCLGTGDNQSTLVPKKLEALCGXKDQNLSYGRGPHVLLSTEDGVFYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTAIQPTPRKVTSCLHAKRVVSIACGQTSSMAVLDSGEVYGWGCNGNGQLGFGNNGNQLTPVRVAALQSVCVNQIVCGYAHTLALTDQGLLYACGANTYGQLGTGSKNNLLSPTSIMVEKERVVEISACHSTHTSAAKTKGGHVYMWVQCRGQSVVLPHLTHFCTDDVFACFATPAASWRLLSVEHEDFLTVAESLKKEFDSPETADLRFRIDGKYNYVHKAVLKIRFEHFRSMFQSYWNEDMKEVIEIDQFSSPVYCAFLQYLSTDTVALQPEDAIGLLDLGTSYCENRLKRLCQHIIKRGITVENTFSLFSAAVRYDAEDLKEFCFKFCINHLTEVTQTTAFWQMDGPXAKASKCGAFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMA8</accession>
    <name>A0A9J7GMA8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100762870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289912.1">
        <property type="nucleotide sequence ID" value="XM_027434111.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100762870"/>
    <dbReference type="KEGG" id="cge:100762870"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15682">
        <property type="entry name" value="PHD_ING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000021">
        <property type="entry name" value="Inhibitor of growth 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF85">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027289912.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28405" checksum="3E01C61CA523E8C1" modified="2023-06-28" version="1">MREIDAQYQEILKELDDFSEKFKHEMHSTRKWRVLHRIQRALIRSQELGDEKIQIVSQMVELVENRTMQVDSHVELFEAHQDISDSTSSSRKPGKDKSRSDVITQADKQNNKRSMRQRNDENRENASNNHDHDDITSGTPKEKKAKTSKRKKRSKAKADREASLTDLPMDPKEPTYCVCNQVSYGEMIGCDNHECPIEWFHFSCVGLNHTPRGKWYCPKCRGEXEXTLDKALEKSKKERAYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMK5</accession>
    <name>A0A9J7GMK5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Sbk3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_027286468.1">
        <property type="nucleotide sequence ID" value="XM_027430667.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GMK5"/>
    <dbReference type="GeneID" id="100768358"/>
    <dbReference type="KEGG" id="cge:100768358"/>
    <dbReference type="CTD" id="100130827"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000577">
        <property type="entry name" value="SH3 domain binding kinase family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF39">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027286468.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="40633" checksum="AE7143E2A9B87C0C" modified="2023-06-28" version="1">MELRALETLEDGDTEEDTAMALQRLVELTASRVTSVRSLRVQYRLIRKLGSGSYGRVLLAQPRQGGKTVALKLLRRDSVLRTTFLREFCVGRCVSSHPGLLQTLGRPLQTPQHFAFAQEYAPYGDLSGMLQEKGLPELMAKRVLAQLAGALDFLHGRGLVHADVKPDNVLVFDPDCNRVALGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLPPNTLPLRPAVDSWALGVLLFCVATACFPWDVALAPDPEFEAFAGWMTTKPQPPRPPAPWDQFAPPALTLLQGLLDLDPETRSPPLAVLDVLGDGWGLRGSAEGSGNLAGVSYEDGEEEEGGSSLEEWTEEEQEEEEEEEEEEEEDEIKDGGRTGSDNRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GN19</accession>
    <name>A0A9J7GN19_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase ERas-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC113838900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027290207.1">
        <property type="nucleotide sequence ID" value="XM_027434406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GN19"/>
    <dbReference type="GeneID" id="113838900"/>
    <dbReference type="KEGG" id="cge:113838900"/>
    <dbReference type="OrthoDB" id="9835289at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027290207.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="24950" checksum="B558E8FD63505291" modified="2023-06-28" version="1">MALPTMSSILDLSLNTQSTRSPEESHEAWEQCKDAGRKLPEYKVVVLGASGVGKSALTIQMTHHCFVKEHDPTVQDSDWKEVALDNSGYILNVLDTSGQDILRALRDQCLAAGDGVLGVFALDDPSSLDQLQQIWSSCSQHQKQRLPLVLVGNKCDLVTTSGDADTAAAILAHKWGVPFVKTSAKTRQGVEEAFALIVHEIQRAQEAVTETSRKKTHQHKAVCSCGCSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GN38</accession>
    <name>A0A9J7GN38_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ly6/PLAUR domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Lypd3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Supports cell migration. May be involved in tumor progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027286932.1">
        <property type="nucleotide sequence ID" value="XM_027431131.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GN38"/>
    <dbReference type="GeneID" id="100770368"/>
    <dbReference type="KEGG" id="cge:100770368"/>
    <dbReference type="CTD" id="27076"/>
    <dbReference type="OrthoDB" id="9834667at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23562">
        <property type="entry name" value="TFP_LU_ECD_LYPD3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23563">
        <property type="entry name" value="TFP_LU_ECD_LYPD3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000016">
        <property type="entry name" value="LY6/PLAUR domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000017">
        <property type="entry name" value="Ly6/PLAUR domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10624:SF8">
        <property type="entry name" value="LY6_PLAUR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10624">
        <property type="entry name" value="UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039928912" description="Ly6/PLAUR domain-containing protein 3" evidence="12">
        <location>
            <begin position="33"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="13">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027286932.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="36549" checksum="7D146127FEA5B612" modified="2023-06-28" version="1">MDAAKRGDAQTVVWTTGWLLLLPLLLCEGAQALECYSCIQKADDGCSPHKMKTVKCGPGADVCTEAVGAVETIHGQFSVAVRGCGSGLQGKNDRGLDLHGILAFIQLQQCTEDRCNNKLNLTLQGLNPAGNESAYEPNGAQCYSCLGKSREECQGTMPPVVNCYNASGRVYKGCFDGNVTLTAANVTVSLPVRGCVQDESCTRDGVTGPGFTLSGSCCQGPRCNSDLRNKTYFSPRIPPLVLLPPPTTLAPSTSTQTSSTSTSKGAATTTNSTTRPTSAPASHTSPHAAEHETVLQEEESRLTGGGAAGHQDRSNTGKTPPKGGAQIPANQGSVVLGSGLPALLLTVVAGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQ40</accession>
    <name>A0A9J7GQ40_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Iduronate 2-sulfatase</fullName>
            <ecNumber evidence="15">3.1.6.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha-L-iduronate sulfate sulfatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Ids</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.</text>
            <dbReference type="EC" id="3.1.6.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer. The 58-kDa mature form is composed of two chains resulting from proteolitic processing, the 42-kDa chain and the 14-kDa chain that remain stably associated and form the 58-kDa intermediate form which is enzymatically active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.13" evidence="15"/>
    <dbReference type="RefSeq" id="XP_027289211.1">
        <property type="nucleotide sequence ID" value="XM_027433410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GQ40"/>
    <dbReference type="GeneID" id="100763345"/>
    <dbReference type="KEGG" id="cge:100763345"/>
    <dbReference type="CTD" id="3423"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000027">
        <property type="entry name" value="iduronate 2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039916724" description="Iduronate 2-sulfatase" evidence="18">
        <location>
            <begin position="29"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="19">
        <location>
            <begin position="45"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027289211.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62503" checksum="D8626A5BF41234EB" modified="2023-06-28" version="1">MSQMPPPPPPPPLGWCLLAFSLLLGSFCFSLESAALDSSATDSLNVLLIIVDDLRPSLGCYGDNLVRSPNIDQLASHSVLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDSPYSWSFPPYHPSSEKYENTKTCRGQDGKLHANLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPQVPDGLPPVAYNPWMDIREREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTEVGHLLSALDDLHLTSNTIIAFTSDHGWALGEHGEWAKYSNFDVATRVPLMFYVPGKTAPLPGAGEKLFPYQDPFDSTSELMDSGRHVMDLVELVSLFPTLAGLSGLQVPPRCPIPSFHVELCREGQSLQKHLQLHDFEEDSYFLGNPRESIAYSQYPRPADFPQWNSDKPSLKDIMIMGYSIRTIDYRYTVWVGFNPAEFLANFSDIHAGELYFVDSDPLQDHNVYNDSQHGGLPHSLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GXU8</accession>
    <name>A0A9J7GXU8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin light chain 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Myosin light chain 1, slow-twitch muscle B/ventricular isoform</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Myl3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulatory light chain of myosin. Does not bind calcium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Myosin is a hexamer of 2 heavy chains and 4 light chains.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035299899.1">
        <property type="nucleotide sequence ID" value="XM_035444008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GXU8"/>
    <dbReference type="GeneID" id="100766026"/>
    <dbReference type="CTD" id="4634"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000056">
        <property type="entry name" value="Myosin light chain 1 skeletal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF2">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035299899.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22222" checksum="4FE46E6044EC524B" modified="2023-06-28" version="1">MAPKKPEPKKDDAKAAAPKAAPAPAAAPAAAPEPERPKEAEFDASKIKIEFTPEQIEEFKEAFLLFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPKQEDLNSKLMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEGSLLLYSSPSLGYPGGKLLCHLLLGPCLIQEIETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GY53</accession>
    <name>A0A9J7GY53_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100772022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300201.1">
        <property type="nucleotide sequence ID" value="XM_035444310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GY53"/>
    <dbReference type="GeneID" id="100772022"/>
    <dbReference type="KEGG" id="cge:100772022"/>
    <dbReference type="OrthoDB" id="9579297at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15234">
        <property type="entry name" value="7tmA_OR7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035300201.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36013" checksum="DA04344852FCFD40" modified="2023-06-28" version="1">MGPKNDTQISQFLLLGISEDPRLQPVLFGLFLAMYLVTVLGNLLIIMITISDSHLHTPMYFFLSNLSFVDICFTSTTVPKMLVNLQSHCKFIVYKDCITQMLSFIFFSGLDIFLLTIMAYDRYVAICHPLHYTVIMNPRLCVLMVLVSWIANALHVSSEGFMVLQLSFCTELKIYHFFCELNQVLQLTCSENFVTVLAMYLLPVLMAAGSLIAILYSYYKIISCIHAISSAQGKYKAFSTCASHLSVVSLFYCTGIGLYLSSVVTENSQSTARASVLYSVVTPMLNPFIYCLRNKDIKKAVKKVFVIESILYLLGLKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H1J7</accession>
    <name>A0A9J7H1J7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">Pih1d1</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7 8 9">17A/GY</strain>
            <tissue evidence="7 8 9">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035302288.1">
        <property type="nucleotide sequence ID" value="XM_035446397.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302290.1">
        <property type="nucleotide sequence ID" value="XM_035446399.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302291.1">
        <property type="nucleotide sequence ID" value="XM_035446400.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315875.1">
        <property type="nucleotide sequence ID" value="XM_035459984.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315876.1">
        <property type="nucleotide sequence ID" value="XM_035459985.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315877.1">
        <property type="nucleotide sequence ID" value="XM_035459986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H1J7"/>
    <dbReference type="GeneID" id="100772372"/>
    <dbReference type="KEGG" id="cge:100772372"/>
    <dbReference type="CTD" id="55011"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="5">
        <location>
            <begin position="242"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035302288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035302290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035302291.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35260" checksum="F923F75A530D47FF" modified="2023-06-28" version="1">MADSKLLVPELSDAESMGDETVRFQELLLQASKELQQAQTDRPESTQIQPQPGFCIKTNSSEGKVFINVCHSPSIPPPVDVTEDELLQMLQEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSNFYLRMQNSDFLRELVVTIAREGLEDKYGLQLNPESKLKWSEGKVAQPLPREAPSEGTLSLRSLVLQPSEWRMLKYRPFLGSISQQNIRSRQRPRIQELGTLQGPERPHLNLWLEAPDLLLAEIDLPRLDGAQGLTLEIGESHLVMGGSQQLYHLNASIPLRINPEASRAAFHHRRKQLMVSMPLLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H1X0</accession>
    <name>A0A9J7H1X0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein crumbs homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Crb1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of a complex composed of PALS1, CRB1 and EPB41L5. Within the complex, interacts (via intracellular domain) with PALS1 and EPB41L5 (via FERM domain). Forms a complex with MPP4 and PALS1. Interacts with MPDZ/MUPP1 and MPP4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the Crumbs protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301718.1">
        <property type="nucleotide sequence ID" value="XM_035445827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765149"/>
    <dbReference type="KEGG" id="cge:100765149"/>
    <dbReference type="CTD" id="23418"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090596">
        <property type="term" value="P:sensory organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000348">
        <property type="entry name" value="Crumbs 1, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000484">
        <property type="entry name" value="Crumbs 1, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000517">
        <property type="entry name" value="Crumbs 1, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000081">
        <property type="entry name" value="Crumbs 1, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000208">
        <property type="entry name" value="Crumbs 2, cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000039">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000274">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000400">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000413">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000055">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000090">
        <property type="entry name" value="Crumbs cell polarity complex component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000252">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 21" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1358"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="319"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="357"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="415"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="459"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="23">
        <location>
            <begin position="501"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="690"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="23">
        <location>
            <begin position="732"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="905"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="23">
        <location>
            <begin position="969"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="1157"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="1195"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="1232"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="1278"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="1315"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1183"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1258"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1303"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="1341"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_035301718.1"/>
        </source>
    </evidence>
    <sequence length="1424" mass="155867" checksum="4E62B21C6B19354E" modified="2023-06-28" version="1">MQCAWLAQVTFFTKIRGKVGVAMILRFLEQRRFLEDEVCIPGFNSFCNINNTRCLSNSCQNNSVCKGFPQDNCCSNIDNILGKGCEDVKDPCLSSPCQGNGTCVTTPGERSFLCQCPLGYSGLTCETAINSCGENSCQHGGTCHKDPEHPVCICPAGYAGRFCETDHNECASSPCHNGAVCQDGINGYSCFCVPGYQGRHCDLEVDECASDPCMNEAVCLNEIGRYICVCPQEYSGVNCELEIDECGSQPCLHGATCQDALGAYFCDCAPGFLGDHCEFNFDECASQPCLHGGLCVDRGGSYHCDCTDSGFTGTHCETLMPLCWSKPCHNNASCEDTVNSYICHCWPGYTGALCETDINECSSNPCQFEGECAELSSEDLYGHIAGLPSSFSYLGASGYICICQPGFTGIHCEEDIDECLQNPCQNGGTCENLPGNYSCHCPFDDISGTFYGGEDCSEVLLGCTHHQCLNNGKCIPHFENGQHGFTCQCPSGYAGSLCQTDTTLSFESNGFLWVTSGSHTTLQSECNVSLRFQTVQPNSLLLFRGNRDMSMKLELLNGCVHLSIQVKNQSNVLLYISHNTSNGEWHLVEVIFAETIMLTLIGSSCKGKCTTKTSFPVENQPSLCAFQNTFLGGLPVGTTNNSVSVLSVYNVPSTPSFVGCLQDIQFDLNHITLENLSSTLSLNVKAGCMRKDWCESEPCQNRGRCINLWQGYQCDCDRPHTGSNCLEEYEAGRFGQDDSAGYAIFNLDDDYGQNFSLSMFVRTRQPSGLLLALENSTYQYVSVWLEHGSLALQSPGLPKLVLNFFLSDGNAHLISLKIKPNEIELYQASQNLGFISVPAWTIQRGDVIFIGGLPDRQKTEVYGGFFKGCIQDIRLNNKNLDFFSNSKNNGHDDPVLVNVTQGCPGDNFCKSNPCHNGGVCYSLWDDFSCSCPTNTAGKACEEVQWCHLSPCPPRAQCQLVPQGFECIANAVFSGLRREILFRSNGNITRELTNITFGFRTRDSNIMILHAEKEPEFLNISIQDSRLLFQLQSGNSFYMLHLMSLQLVNDGIWHQVTFSMIDPLAQTSRWQMGVDNQTPLVTSTIATGSLNFLKDNTDIYVGDQAIDNTKGFQGCLSTIEIGGIYLSYFENLHSFMNKPQEEQFLKVSTNVVLTGCLPLNACHSSPCLHGGNCEDSYSSYQCSCLLGWSGTHCEINIDECFSNPCIHGNCSDGVAAYHCRCEPGYTGVNCEVDIDNCKNHRCANGATCVSGTHGYSCLCFGNFTGRFCRHSRLPSTACGNEETNLTCYNGGNCTEVQEERKCMCWPGFTGEWCEANIDECASDPCLHGGLCRDLVNRFQCICDAAFAGERCELDLADDWLVGIFTAVGSGTLVLLFILLLAAVASLVASKKRATQGTYSPSGQEKAGPRVEMWSRMPPPALERLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2J6</accession>
    <name>A0A9J7H2J6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100760192</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035302921.1">
        <property type="nucleotide sequence ID" value="XM_035447030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760192"/>
    <dbReference type="KEGG" id="cge:100760192"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051718">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.50">
        <property type="entry name" value="PWWP, helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040552">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049554">
        <property type="entry name" value="DNMT3_ADD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF55">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17980">
        <property type="entry name" value="ADD_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21255">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="330"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035302921.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="79209" checksum="CAD985677B5F12FE" modified="2023-06-28" version="1">MKRNGRHLSDEEGVSGCEDCVIITGTCSDQSSDAKDVTLTQVLEAFCPVENSGCRASSRRFKRRVSNTVTYFQSLSWQATTSASTPWLFPTSPYPTIDLTDEEVILQSISTPLVDLSQDSHQESMDTTQVDVGSRDEDTTKYQDEKEFGIGDLVLEKAEGFCWWPVMEVFWKATFQLQAMLHMQWGQWFGDGKFSEVSADKLVTFGXLFSQHYNLYPFNKLFSMVSYRKVTYHTRRARVRAGKTFPSSPGDSLEDKLKPMLEWAHGGFKPIGIEGLKPNKQPENKSRRGTTNNDSAASESYPPPKHLKTNSYGGKDRGQDDESREQMASDVTNNKGNLEDRCLSCGRKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCKGRELLLCSNTSCCRCFCVECLEVLVGTGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTSDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYVASEVCTESIAVGTVKHEGQIKYVDDVRNITKGNIDEWGPFDLVIGGSPCNDLSCVNPGRKGLFEGTGRLFFEFYRLLNYARPEECDNRPFFWMFENVVAMEVGDKRDISLFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRIFGFPSHYTDVSNMGRGARQKLLGKSWSVPVIRHLFAPLKDYFACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2T0</accession>
    <name>A0A9J7H2T0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118237738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035302655.1">
        <property type="nucleotide sequence ID" value="XM_035446764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H2T0"/>
    <dbReference type="GeneID" id="118237738"/>
    <dbReference type="KEGG" id="cge:118237738"/>
    <dbReference type="OrthoDB" id="9870582at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035302655.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="37191" checksum="6A74B82A088B7799" modified="2023-06-28" version="1">MLKSSSLMPSWDRPVLPEAPGCELAGGVARAHPIKHGVVVDWDAMEGLWERLMVGGLQVHPEQWPVLVSDSPSAPPEGREKAAELLFEALTVPACHMASTALLALCSTGAFSGLAVEAGAGVCHATPIYAGHSWQKATFRLNVAGSSLSRYFRDLLMATSPDLQPQALPRKTVTHLKKRCCYVSLDFQGDICNPARHRRACFCLSNGCCVHLGSERFRCPEPLFQPSLLDHPEPGLPTLAFQALQKIPITLRARLANTVVLAGGSTLFPGFVERMNLELEALCQRLGHPALKLCLVAQPGRGTAVWTGGSMMASLQSFQCRWMTRAMYEEYGPFLVRKVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H750</accession>
    <name>A0A9J7H750_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="13">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Inactive ubiquitin carboxyl-terminal hydrolase 52</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="13">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">Pan2</name>
        <name evidence="13" type="synonym">PAN2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18">17A/GY</strain>
            <tissue evidence="17 18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="13">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with PAN3 isoform 1/Pan3L and isoform 3/Pan3S. Interacts with ZFP36.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <text evidence="13">Shuttles between nucleus and cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="13"/>
    <dbReference type="RefSeq" id="XP_035306309.1">
        <property type="nucleotide sequence ID" value="XM_035450418.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306310.1">
        <property type="nucleotide sequence ID" value="XM_035450419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H750"/>
    <dbReference type="GeneID" id="100765354"/>
    <dbReference type="CTD" id="9924"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02672">
        <property type="entry name" value="Peptidase_C19P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000059">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000011">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000017">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="523"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1183"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="983"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="985"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1092"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1144"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035306309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035306310.1"/>
        </source>
    </evidence>
    <sequence length="1208" mass="136396" checksum="117EE3C76ECC8A09" modified="2023-06-28" version="1">MNFEGLDPGLAEFSPAMHSTLDPVLDAHLNPSLLQNVELDPEGVALEALPVQESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQVNGSDDIRQIQSLENGILFLTKNNLKYMARGGLIIFDYLLDECEDMHSLLLTDNSTLLIGGLQNHVLEIDLNTVQETQKYAVEIPGVTIMRQTNRFFFCGHTSGKISLRDLRSFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANPADIFHVNPVGPLLMTFDVSASKQALAFGDSEGCVHLWTDSPEPSFNPYSRETEFALPCLVDSLPPLDWSQDLLPLSLIPVPLTTDTLLSDWPAANSAPAPRTILAYRRAPPVDAEILRTMKKVGFIGYAPNPRTRLRNQIPYRLKESDSEFDNFSQVTESPIGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASALGLILADSDEASGKGSLARLIQRWNRFILTQLHQDMQELEGPQAYRGAGGSSFCSSGDSVIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPEGSICDKTGKNYDFAHVLKRSICLEQNTQAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWRLQAEVAFKIAVKKYGGEIKNKEFTLADRKEPRSAEGLLYCSSIEEMKNVWLPFSIRMKMTKNKGLDVCNWTDGDEMQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKYEAVQFDMNWKVPAILYYVKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQVGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPESQTSPKSKAGLRQGDWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H752</accession>
    <name>A0A9J7H752_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC103159270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035304931.1">
        <property type="nucleotide sequence ID" value="XM_035449040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103159270"/>
    <dbReference type="KEGG" id="cge:103159270"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000126">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000021">
        <property type="entry name" value="glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF12">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="323"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="439"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035304931.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="68393" checksum="47D244C133E817C8" modified="2023-06-28" version="1">MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMEIQQIMKGLKDHITEIQRCQLLILIAVAQVTTLTRQGLEELTELLVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGAVTVGITNTVSSSISRETDCGVHINAGPEIGVASTKSMDDEIQKLXQQKSFLIKGRGYHYATWLEGALKIKEITYMHSEGILAGELKHGSLALLDKLMPVIMIIMRYHTYAKCQNALQQVVAQQGCPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVSDHLCRTMGWLLTRVDFPWNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HAQ9</accession>
    <name>A0A9J7HAQ9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Krueppel-like factor 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC107979239</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4">17A/GY</strain>
            <tissue evidence="3 4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035307983.1">
        <property type="nucleotide sequence ID" value="XM_035452092.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307984.1">
        <property type="nucleotide sequence ID" value="XM_035452093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HAQ9"/>
    <dbReference type="GeneID" id="107979239"/>
    <dbReference type="KEGG" id="cge:107979239"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035307983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035307984.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="8981" checksum="6FBB1B6548B7EE05" modified="2023-06-28" version="1">MVSSPGGRGLRRRGGAAAAAAARMCLLAPAPAPAPSSAPPPAAPPPQLLRAPPPTPATTGCAFWEMDICHCWGSRDKKMTVNLIQPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCU0</accession>
    <name>A0A9J7HCU0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: hereditary hemochromatosis protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118239794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309635.1">
        <property type="nucleotide sequence ID" value="XM_035453744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCU0"/>
    <dbReference type="GeneID" id="118239794"/>
    <dbReference type="KEGG" id="cge:118239794"/>
    <dbReference type="OrthoDB" id="9449998at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000003">
        <property type="entry name" value="IgG receptor FcRn large subunit p51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000204">
        <property type="entry name" value="Major histocompatibility complex, class I-related protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF139">
        <property type="entry name" value="MHC CLASS I-LIKE PROTEIN MILL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="364"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035309635.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="54735" checksum="DC9289D7CBE364C6" modified="2023-06-28" version="1">MAAVALDRDMTLASSSGPDITMALGGKQATYVITLLTAFISWICLSPQKEELLAADSRDNKTSHYQSPPKVKVTNKKYPKGRISLSCWAFNLYPPVAILVWLQGGKPVQQQTFGPGTILPGGDETYQTWVSIWVLPGQEPEFTCHLRPLVSLDIKPGKLVGPPALLQLWWLLLLAELTVGTHELISTGPHTLRFDLMTTSLDVPDKILALGYFDDKPFLRYKGDNRTAEALTPGLRGHAGAETQARETEGLWKKQLRAMVAEVARQIDQDRGNHTIQVTFGCELHRNGSTRGFWRLGYDGQDSITFDQKTLTWTMAVPSTQQTRNFREIYAPKAAQVFLKDTCPAQLQECLDSSKNILLNTGAPKVKVTSRRYPVGRITLTCWAFNLYPPVATLVWLQGGKPVQQQNFGPGTILPSGDGTYQTWVSIWVLPGQEPEFTCCLRNCSKNIVDPVFLGEKMGQPFTSGVGGKVRESLWSTITKVFLLASRTSRQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JCV0</accession>
    <name>A0A9J7JCV0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Sortilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Neurotensin receptor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="primary">Sort1</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="37" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
            <tissue evidence="38">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="27">Cell membrane</location>
            <topology evidence="27">Single-pass type I membrane protein</topology>
            <orientation evidence="27">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Golgi apparatus</location>
            <location evidence="29">Golgi stack membrane</location>
            <topology evidence="29">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Nucleus membrane</location>
            <topology evidence="28">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="30">Belongs to the VPS10-related sortilin family. SORT1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027251292.1">
        <property type="nucleotide sequence ID" value="XM_027395491.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JCV0"/>
    <dbReference type="GeneID" id="100750717"/>
    <dbReference type="KEGG" id="cge:100750717"/>
    <dbReference type="CTD" id="6272"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000003">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000802">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000004">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF23">
        <property type="entry name" value="SORTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-0221">Differentiation</keyword>
    <keyword evidence="21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="26" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="24" id="KW-0458">Lysosome</keyword>
    <keyword evidence="19 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="20" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0675">Receptor</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 35" id="KW-0732">Signal</keyword>
    <keyword evidence="10 34" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 34" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="35">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039928581" description="Sortilin" evidence="35">
        <location>
            <begin position="32"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="36">
        <location>
            <begin position="131"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="742"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00046292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00060431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00061605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00068731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00080429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="RefSeq" id="XP_027251292.1"/>
        </source>
    </evidence>
    <sequence length="858" mass="94767" checksum="5AC2E3B0E694844E" modified="2023-06-28" version="1">MERPRGAADGLSRWPLGLLLLLQLLPPAAVGQDRLDAPPPPAPPPLRWAGPVGVSWGLRAAAPGGPVPRAGRWRRAAPAEDQGCGRLPDFVAKLANNTHQHVFDDLSGSVSLSWVGDSTGVILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFARNFVQTDLPFHPLTQMLYSPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWGSDNIIFFTTYVNGSCKADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSMLSEDNSIQSMITFDQGGRWEHLQKPENSKCDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFTQEPIYFTGLASEPGARSMNISIWGFTESFITRQWVSYTVDFKDILERNCEEDDYTTWLAHSTDPGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVAAKQPSFCPCSLEDFLCDFGYFRPENASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDRCQGGMNPAREVKDLKKKCTSNFLNPKKQDSRPQGHSLSQNPAPPPHGYTENTHFLSPTQKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEADGVDALDTASHAKSGYHDDSDEDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JDG0</accession>
    <name>A0A9J7JDG0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Hairy/enhancer-of-split related with YRPW motif protein 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Hey2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HEY family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027254231.1">
        <property type="nucleotide sequence ID" value="XM_027398430.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JDG0"/>
    <dbReference type="GeneID" id="100755611"/>
    <dbReference type="KEGG" id="cge:100755611"/>
    <dbReference type="CTD" id="23493"/>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003181">
        <property type="term" value="P:atrioventricular valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060317">
        <property type="term" value="P:cardiac epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003208">
        <property type="term" value="P:cardiac ventricle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014031">
        <property type="term" value="P:mesenchymal cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003151">
        <property type="term" value="P:outflow tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003184">
        <property type="term" value="P:pulmonary valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014706">
        <property type="term" value="P:striated muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048729">
        <property type="term" value="P:tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060412">
        <property type="term" value="P:ventricular septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18920">
        <property type="entry name" value="bHLH-O_HEY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000012">
        <property type="entry name" value="hairy/enhancer-of-split related with YRPW motif protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="12">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027254231.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="35815" checksum="BAB7DFC49D969122" modified="2023-06-28" version="1">MKRPCEETTSESDMDETIDVGSENNYSGQSAGSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCASQREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEVPPAHGSALLTATFAHADSALRMPTTGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSNAAAAVAAATAISPPLSVSAASSPQQTSNGTNNKPYRPWGTEVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JDU3</accession>
    <name>A0A9J7JDU3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 4A10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC113832988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027248405.2">
        <property type="nucleotide sequence ID" value="XM_027392604.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258086.2">
        <property type="nucleotide sequence ID" value="XM_027402285.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JDU3"/>
    <dbReference type="GeneID" id="113832988"/>
    <dbReference type="KEGG" id="cge:113832988"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008391">
        <property type="term" value="F:arachidonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046456">
        <property type="term" value="P:icosanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048252">
        <property type="term" value="P:lauric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF165">
        <property type="entry name" value="CYTOCHROME P450 4A10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027258086.2"/>
        </source>
    </evidence>
    <sequence length="137" mass="15368" checksum="0239B6F468F4D1F8" modified="2023-06-28" version="1">MKAYVRGVHPFLFNTQASKVLPLREARAQFGALSGVSVTLSIYALHHNPKVWPNPEVFDPSRFASDSPRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPLPRLVFKSKNGIYLHLEKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JV50</accession>
    <name>A0A9J7JV50_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low-density lipoprotein receptor class A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC113834157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035296405.1">
        <property type="nucleotide sequence ID" value="XM_035440514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JV50"/>
    <dbReference type="GeneID" id="113834157"/>
    <dbReference type="KEGG" id="cge:113834157"/>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057430">
        <property type="entry name" value="LDLRAD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25241">
        <property type="entry name" value="LDLRAD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDLRAD1-like C-terminal" evidence="3">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035296405.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11117" checksum="B043DD4A46D75F66" modified="2023-06-28" version="1">MDCGYGGDESATYCGQMPNSLPPNLIFKCPNQKTWIYVDRVCDTKNDCGDCSDESVSQCPACSGWRCDTVFFADCACIPRSRCRNGIQDCTDWSDENLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JVW0</accession>
    <name>A0A9J7JVW0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100759404</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283212.1">
        <property type="nucleotide sequence ID" value="XM_027427411.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JVW0"/>
    <dbReference type="GeneID" id="100759404"/>
    <dbReference type="KEGG" id="cge:100759404"/>
    <dbReference type="OrthoDB" id="9898717at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15421">
        <property type="entry name" value="7tmA_OR2T-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="45"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027283212.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36146" checksum="6CFD2ADD094DDDAF" modified="2023-06-28" version="1">MNFTNWISNYTRQSDFTLMGFFSQSKHPALLAVVIFVVFLMALSGNGLLILLIHSDTRLHTPMYFFISQLSLMDMIYISVTVPKMLMDQVLGSHKISAAACGMQMFLYATLGGSEFFLLAAMSYDRYVAICHPLRYPVLMNQRVRLLLMSVCWFLGSLDGFILTPVTMTFPFCGSREIHHFFCEVPAVTKLSCSDTWLYETLMYLCCVLMLLIPVTVISSSYSSILLTVIRMNSAEGRKKALATCSSHMTVVILFYGAAVYTYMLPASFHTPEKDMVVSAFYTILTPLLNPLIYSLRNKNVTEALKKLLGVRTLFQETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JVW3</accession>
    <name>A0A9J7JVW3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Deoxyribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC107980331</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the DNase I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027280717.1">
        <property type="nucleotide sequence ID" value="XM_027424916.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JVW3"/>
    <dbReference type="GeneID" id="107980331"/>
    <dbReference type="KEGG" id="cge:107980331"/>
    <dbReference type="OrthoDB" id="10061407at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10282">
        <property type="entry name" value="DNase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000047">
        <property type="entry name" value="Deoxyribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018057">
        <property type="entry name" value="Deoxyribonuclease-1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
        <property type="entry name" value="DNase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033125">
        <property type="entry name" value="DNASE_I_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371">
        <property type="entry name" value="DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371:SF29">
        <property type="entry name" value="DEOXYRIBONUCLEASE-1-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000988">
        <property type="entry name" value="DNase_I_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00130">
        <property type="entry name" value="DNASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00476">
        <property type="entry name" value="DNaseIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00919">
        <property type="entry name" value="DNASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00918">
        <property type="entry name" value="DNASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039941866" description="Deoxyribonuclease" evidence="16">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="17">
        <location>
            <begin position="26"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Essential for enzymatic activity" evidence="15">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000988-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000988-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027280717.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31055" checksum="181F306648B3AEB3" modified="2023-06-28" version="1">MGWPRSLLAALWALWAMEATALRLGAFNIQSFGDNKVSDPDCGSVIAQILAGYDIVLVQEVRDPDLSALSLLMEQINRESKHEYSFVSSKPLGRDQYKEMYLFVYRKDAVSVISTYQYPDPEDAFSREPFVVKFSAPSSAAKELVLIPLHAAPHQAVAEIDALYDVYLDVIDKCNTDDMVFLGDFNADCKYVKAQDWVSIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVVSGAHLPKSLKAQSASVHNFQEEFGLDQTQALAISDHFPVEVTFKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JWD4</accession>
    <name>A0A9J7JWD4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein WFDC9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Wfdc9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003504631.1">
        <property type="nucleotide sequence ID" value="XM_003504583.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279045.1">
        <property type="nucleotide sequence ID" value="XM_027423244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JWD4"/>
    <dbReference type="GeneID" id="100760594"/>
    <dbReference type="KEGG" id="cge:100760594"/>
    <dbReference type="CTD" id="259240"/>
    <dbReference type="OrthoDB" id="9699870at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039946945" evidence="1">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027279045.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9958" checksum="39A4EA9394777BF9" modified="2023-06-28" version="1">MRLQILFLMVSIHEMVVFLYVLGSFNKHDQTEEIDQCWVQPPKSFCGKRCTRMNECMSANHTCCWTYCGNICLDNGEPFKTLMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K1X3</accession>
    <name>A0A9J7K1X3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Septin6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Filament-forming cytoskeletal GTPase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Septins polymerize into heterooligomeric protein complexes that form filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027287726.1">
        <property type="nucleotide sequence ID" value="XM_027431925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K1X3"/>
    <dbReference type="GeneID" id="100768230"/>
    <dbReference type="KEGG" id="cge:100768230"/>
    <dbReference type="CTD" id="23157"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000036">
        <property type="entry name" value="septin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="11">
        <location>
            <begin position="39"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="321"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027287726.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49618" checksum="F747091C463A0294" modified="2023-06-28" version="1">MAAADIARQVGEGCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLFNTKFEGEPATHTQPGVQLRSNTYDLQESNVGLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKSDAISKSELTKFKIKITSELVSNGVQIYQFPTDDESVAEINGTMNAHLPFAVVGSTEEVKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQEEKKKLEDKKKSLDDEVNAFKQRKTAAELLQSQGSQAGGSQTLKRDKEKKNNPWLCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K861</accession>
    <name>A0A9J7K861_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neuron navigator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Pore membrane and/or filament-interacting-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Nav1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May be involved in neuronal migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nav/unc-53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301435.1">
        <property type="nucleotide sequence ID" value="XM_035445544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763751"/>
    <dbReference type="KEGG" id="cge:100763751"/>
    <dbReference type="CTD" id="89796"/>
    <dbReference type="OrthoDB" id="2161974at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043194">
        <property type="term" value="C:axon initial segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000409">
        <property type="entry name" value="Neuron navigator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057126">
        <property type="entry name" value="NAV1-like_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF3">
        <property type="entry name" value="NEURON NAVIGATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23092">
        <property type="entry name" value="Ubiquitin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1823"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
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    <sequence length="2150" mass="231515" checksum="447CCD83035197FD" modified="2023-06-28" version="1">MNGMANVNSASRPHYASSIPVPRASSQTRIHTPGASPQLRPRQADLALSPQRAASPRRGKAAVSSRNSSPKAYRGRGTPRASGPARELSENVESLPSSPWSSPRVTPKRSLSSQTGSRRAGETQSTQRKKNQEGISVRQTRGRSPPQTSCHGETQIPGPSEGRMLPSCQEKDQRDKNYKPPRSLEPDEGAASGTSCPVYSPMQSKRPSPTPGAISFSSAHQQNQPITATVAPFQYRLQTDQEPGPGPQENWALDGYTSLPGRTEDTFSCMDARIVHALLAGRMLGSSVKSVQPEVELSGGSGSGGDEGADEPRGASRKAAAADGRGMLPKRAKAAGGGGSMAKASAAELKVFKSGSVDSRVPGGPPTSNLRKQKSLTNLSFLTDSEKKLQLYEPEWSDDMAKAPKGLGKLGPKGRETPLMSKTLSKSEHSLFQPKGGPTGGAKTPLAPLAPSLGKPSRIPRGPYAEVKPLSKAPEAAVSDDGKSDDELLSSKAKAQKGSGTVPSAKGQEERAFLKVDPELVVTVLGDLEQLLFSQMLDPESQRKRTVQNVLDLRQNLEETMSSLRGSQVTHSSLEMTCYDSDDANPRSVSSLSNRSSPLSWRYGQSSPRLQAGDAPSVGGSCRSEGPPAWYMHGERAHYSHTMPMRSPSKLSHISRLELVESLDSDEVDLKSGYMSDSDLMGKTMTEDDDITTGWDESSSISSGLSDASDNLSSEEFNASSSLNSLPTTPTASRRSSTIVLRTDSEKRSLAESGLNWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLTVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPSKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPPATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTHASKVPDLHATSSSTGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSSPVPTPPAAPAAPSEEETEELPWSGSPRAGQLDSSQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQAELPSPPALSMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAERSKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASEATPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTEVTEAPAHSVPHTRLFQASEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALSHPFSPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSLSHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTDGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLCHLPPPSVGPHSIASPPEDRTVKDSTPSSLDSDPLMAMLLKLQEAANYIESPDRETILDPNLQATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K8S3</accession>
    <name>A0A9J7K8S3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial glutamate carrier 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glutamate/H(+) symporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Solute carrier family 25 member 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Slc25a18</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamate(in) + H(+)(in) = L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304472.1">
        <property type="nucleotide sequence ID" value="XM_035448581.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035457911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K8S3"/>
    <dbReference type="GeneID" id="100756941"/>
    <dbReference type="KEGG" id="cge:100756941"/>
    <dbReference type="CTD" id="83733"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000026">
        <property type="entry name" value="Putative mitochondrial glutamate carrier 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF11">
        <property type="entry name" value="MITOCHONDRIAL GLUTAMATE CARRIER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="100"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035304472.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="33390" checksum="19292393C46C5F67" modified="2023-06-28" version="1">MSSQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQQGKDVYKGMTDCLMKTARAEGFLGMYRGAAVNLTLVTPEKAIKLAANDFLRQLLMQDGTQRNLKMEMLAGCGAGICQVVVTCPMEMLKIQLQDAGRLAVSHQGSASAAPTSRPYSTGSASTHRRPSATLIARELLRTQGLWGLYRGLGATLLRDIPFSIIYFPLFANLNQLGVSEVTGKAPFAHSFVAGCAAGSVAAVAVTPLDVLKTRIQTLKKGLGEASYSGVTDCARKLWTQEGAAAFMKGAGCRALVIAPLFGIAQGIYFIGIGERILKCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K9T9</accession>
    <name>A0A9J7K9T9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein C1orf105 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CUNH1orf105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035298270.1">
        <property type="nucleotide sequence ID" value="XM_035442379.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301710.1">
        <property type="nucleotide sequence ID" value="XM_035445819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K9T9"/>
    <dbReference type="GeneID" id="103160216"/>
    <dbReference type="KEGG" id="cge:103160216"/>
    <dbReference type="CTD" id="101642985"/>
    <dbReference type="OrthoDB" id="9832160at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027845">
        <property type="entry name" value="DUF4548"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39410">
        <property type="entry name" value="RIKEN CDNA 4930558K02 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39410:SF1">
        <property type="entry name" value="RIKEN CDNA 4930558K02 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15081">
        <property type="entry name" value="DUF4548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035301710.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41653" checksum="16313CC01906392A" modified="2023-06-28" version="1">MTSLTQNAKYLTQHYKLVPVPLYLPVNFGVLTPKVRVSGQGRVRSCAVTHPAGLPRPPPPPVSHPALAQRYQPDRKDAGTHLHRALRGARLRRAAAQRFLHPGRGVGGYRCEGALPALHHSAAKAALTETAHREVAAALYWLLLSRRSAQSAISAPGRKGSSSRVQREEKAFVPKFDKVPWLSEASLVNKPLVLSLPGRYPASATILTLPRKDMDLQNFLQVPDAMSKARKNGHENLLPRNKQLYSTYREVKTVQPKNFTIPDYEEKSSSQNSVNHRVMFIHHPHVQQFNQCYHKTESIGYRLPIMGPRTAIFHGLLSSAYHTPQETQHLSFPRNKRMMKTMKQGVVKDNYPQMFREETTSPSSSDTSSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KBU9</accession>
    <name>A0A9J7KBU9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="26">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">Itk</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
            <tissue evidence="33">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 26">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homooligomerizes; this association negatively regulates kinase activity. Interacts with PPIA/CYPA; this interaction regulates TCR signal strength via a proline-directed conformational switch in ITK. Interacts with THEMIS. Interacts with FASLG. Interacts with VAV1; this interaction is important for VAV1 localization and TCR-induced actin polarization. Interacts with TBX21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="26">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="26"/>
    <dbReference type="RefSeq" id="XP_035303863.1">
        <property type="nucleotide sequence ID" value="XM_035447972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KBU9"/>
    <dbReference type="GeneID" id="100770087"/>
    <dbReference type="CTD" id="3702"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01238">
        <property type="entry name" value="PH_Btk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05112">
        <property type="entry name" value="PTKc_Itk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10396">
        <property type="entry name" value="SH2_Tec_Itk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11908">
        <property type="entry name" value="SH3_ITK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000244">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000176">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000061">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042785">
        <property type="entry name" value="ITK_PTKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035583">
        <property type="entry name" value="ITK_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00402">
        <property type="entry name" value="TECBTKDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="13 25 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0391">Immunity</keyword>
    <keyword evidence="11 26 33" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 25 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 22" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4 23" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7 26" id="KW-0808">Transferase</keyword>
    <keyword evidence="18 26" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="30">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="29">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="28">
        <location>
            <begin position="242"/>
            <end position="340"/>
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    </feature>
    <feature type="domain" description="Protein kinase" evidence="31">
        <location>
            <begin position="365"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065420"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_035303863.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="71896" checksum="F579DD2CE2A91536" modified="2023-06-28" version="1">MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVMHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHPNFWMDGRWRCCSQLEKLAVGCAPYDPTKNASKKPLPPTPEDNRVSERSLQEPEETLVIALYDYQTNDPQELALQCDEEYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNSLETYEWYNKNISRDKAEKLLLDTGKEGAFLVRDSRIPGTYTVSVFTKAIISENPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLIKYHQYNGGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIHPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASSNVYQIMNHCWKEKPEDRPPFSQLLSQLAEIAESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3GXD8</accession>
    <name>G3GXD8_CRIGR</name>
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        <submittedName>
            <fullName evidence="3 6">Coiled-coil domain-containing protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ccdc57</name>
        <name evidence="3" type="ORF">I79_002428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000058">
        <property type="protein sequence ID" value="EGW06287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007652445.1">
        <property type="nucleotide sequence ID" value="XM_007654255.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281137.1">
        <property type="nucleotide sequence ID" value="XM_027425336.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GXD8"/>
    <dbReference type="STRING" id="10029.G3GXD8"/>
    <dbReference type="PaxDb" id="10029-XP_007652445.1"/>
    <dbReference type="GeneID" id="100771842"/>
    <dbReference type="KEGG" id="cge:100771842"/>
    <dbReference type="CTD" id="284001"/>
    <dbReference type="eggNOG" id="ENOG502QSW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3GXD8"/>
    <dbReference type="OMA" id="RNLKHKF"/>
    <dbReference type="OrthoDB" id="568502at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045931">
        <property type="term" value="P:positive regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042481">
        <property type="entry name" value="CCDC57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="740"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGW06287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027281137.1"/>
        </source>
    </evidence>
    <sequence length="1007" mass="115355" checksum="A6EB5E4D2F275860" modified="2011-11-16" version="1">MLPLCSEKELGELLARKEEEWRALQAHRAQLQETTLQTTRKHLEETQGKLQRLQEDFVYNLQVLEERDRELERYDVEFTQARRREEAHQAEASELKIEVAKLKQALTRETRHVEELQHRHQLMLQEHHLELERIHSDKKSEVDHHQGQYESLKWTLERKLRELDGELALQRQELLQEFESEIQRKDHEFQLRADDMSNVVLTHELKVKLLNKELQALREAGAQATESLQKAKAEHIQLQRKLQDHALELQSLEAVKDARIKDLEKKLQSVQLARKRAEETFRRKNEELDRQAREKDTLLAAVKGSHAKQLHELEAKMLELQAHCETLEGQLRKAEWIRADDAKEKNALIDKLHEDAAALKAAWDAQITQMSKEAVSKDLQVQKLQEEEAKLKAQVAGFQKDIDRYKQQLSLAVEREQSLERDHVQLGLDWQRRCDDVERDHIQRSEALIRGLTRARDQVSAKLEETEKALHRQETLLKAVSLERDQAMETLRRHGLLPGQEAQVPPQQRDRETRKDFPSSEIQRLQEQNAGLRNAVAQMRREMELLSGHLPSAHPEECPDANPGAKAAGGPALPDHFLALEAEIQNLKHKLEVLEEQRQGVREPVKTSLPTDDPHPGAAVTDQACIALALRKLGDRVHLLNLLVTQLKKKLWQKPLEPVTVQHELPGEVDQVHLEVVELQKQVAELRKHVKVAGPRGEPAYTEQLQREGLTDWRPMVTMDQTEFTSLPQEGAQPPQTLSVPHLQKKLKDAARKIRSLSLEREQLLEMGNRLRAELGHPKGKLTPCTLPPTSESRDPRERPETPLDPGLPLKQLQPHSTTQDPRHTTRKCVSEYLGENQPHSVQVGSKCNIPRGYTAGVASRPAQKQHRVPTETLKSVCQKENRSPKLPPQAQEVPEESDHHTHRSSSLTSSSLQDTWKLLDLGSSLSGVTSQDDSAAERLAPPGASCLQKVHQSPVTTQSTFAVKGLKMEAQPKVTHPRPRKAHPAEPTNCWQRQRHPRIRNYNLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3GXU2</accession>
    <name>G3GXU2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17 18" type="primary">Nrbp1</name>
        <name evidence="13" type="ORF">I79_002585</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18">17A/GY</strain>
            <tissue evidence="17 18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm. Interacts with ELOC/TCEB1, ELOB/TCEB2, TSC22D2 and TSC22D4. Interacts with the Elongin BC E3 ubiquitin ligase complex via its interaction with ELOB/TCEB2 and ELOC/TCEB1. Interacts with SALL4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000061">
        <property type="protein sequence ID" value="EGV95881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280249.1">
        <property type="nucleotide sequence ID" value="XM_027424448.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280250.1">
        <property type="nucleotide sequence ID" value="XM_027424449.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035294523.1">
        <property type="nucleotide sequence ID" value="XM_035438632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GXU2"/>
    <dbReference type="SMR" id="G3GXU2"/>
    <dbReference type="STRING" id="10029.G3GXU2"/>
    <dbReference type="PaxDb" id="10029-XP_007613698.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000270.1">
        <property type="protein sequence ID" value="ENSCGRP00001000246.1"/>
        <property type="gene ID" value="ENSCGRG00001000214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768309"/>
    <dbReference type="KEGG" id="cge:100768309"/>
    <dbReference type="CTD" id="29959"/>
    <dbReference type="eggNOG" id="KOG1266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1034557at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14034">
        <property type="entry name" value="PK_NRBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000181">
        <property type="entry name" value="Nuclear receptor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000098">
        <property type="entry name" value="Nuclear receptor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 17 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="68"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV95881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027280249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027280250.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="59793" checksum="99A79F7919390AB2" modified="2011-11-16" version="1">MSEGESQTVVSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDSLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPDLAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYB2</accession>
    <name>G3GYB2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Med11</name>
        <name evidence="10" type="synonym">MED11</name>
        <name evidence="11" type="ORF">I79_002786</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGV93927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497246.1">
        <property type="nucleotide sequence ID" value="XM_003497198.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282732.1">
        <property type="nucleotide sequence ID" value="XM_027426931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYB2"/>
    <dbReference type="STRING" id="10029.G3GYB2"/>
    <dbReference type="PaxDb" id="10029-XP_007625140.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011716.1">
        <property type="protein sequence ID" value="ENSCGRP00001007656.1"/>
        <property type="gene ID" value="ENSCGRG00001010051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768888"/>
    <dbReference type="KEGG" id="cge:100768888"/>
    <dbReference type="CTD" id="400569"/>
    <dbReference type="eggNOG" id="KOG4057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3490:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV93927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027282732.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3H7E4</accession>
    <name>G3H7E4_CRIGR</name>
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        <submittedName>
            <fullName evidence="11">Jerky protein homolog-like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Jerky protein-like-like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Jrk-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Jrkl</name>
        <name evidence="7" type="ORF">I79_006275</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000193">
        <property type="protein sequence ID" value="EGW00893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003500130.1">
        <property type="nucleotide sequence ID" value="XM_003500082.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270944.1">
        <property type="nucleotide sequence ID" value="XM_027415143.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H7E4"/>
    <dbReference type="STRING" id="10029.G3H7E4"/>
    <dbReference type="PaxDb" id="10029-XP_007631633.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012747.1">
        <property type="protein sequence ID" value="ENSCGRP00001008618.1"/>
        <property type="gene ID" value="ENSCGRG00001010876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763189"/>
    <dbReference type="KEGG" id="cge:100763189"/>
    <dbReference type="CTD" id="8690"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161513"/>
    <dbReference type="OMA" id="SRAWKQI"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF16">
        <property type="entry name" value="JERKY PROTEIN HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGW00893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027270944.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59828" checksum="8516D6DC4B18009C" modified="2011-11-16" version="1">MSGKRKRVVLTIKDKLDIIKKLEDGGSSKQLAVIYGIGETTVRDIRKNKEKIITYASSSDSTSLLAKRKSMKPSMYEELDRAMLEWFNQQRAKGNPVSGSICAKRAEFFFYALGMDGDFNPSAGWLTRFKQRHSIREINIRNERLSGDDRAVEDFCKNFRDFIERENLQPEQIYNADETGLFWKCLPSRTSVIKGKRTVPGHNSFEERVTVMCCTNATGLHKLKLCVVGKAKKPRSFKSTDTLNLPVSYFSQKGAWMDLSIFRQWFDKIFVPQVREYLRSKGLQEKAVLLLDNSPAHPNENVLRSDDGQIFAKCLPPNIASSIQPLDQGVIATMKRNYRAGLLQNNLEEGNDLKSFWKKLTLLDALYEIAMAWNLVKPVTISRAWKQILPSIEEKEGLDFDEEDISGATVATILQHTKGLENVTPENMEKWLEIDSTEPGYEVLTDSEIIRRAQGQTDESSENDEEGIELIPEKHINHAAALQWTENLLDYLEQQGDMILPDRLVVRKLRATIRNKQKMTNPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3HCS2</accession>
    <name>G3HCS2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable helicase with zinc finger domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Helz</name>
        <name evidence="16" type="ORF">I79_008287</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000285">
        <property type="protein sequence ID" value="EGV99146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016830799.1">
        <property type="nucleotide sequence ID" value="XM_016975310.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281648.1">
        <property type="nucleotide sequence ID" value="XM_027425847.2"/>
    </dbReference>
    <dbReference type="STRING" id="10029.G3HCS2"/>
    <dbReference type="PaxDb" id="10029-XP_007640682.1"/>
    <dbReference type="GeneID" id="100766882"/>
    <dbReference type="CTD" id="9931"/>
    <dbReference type="eggNOG" id="KOG1804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HCS2"/>
    <dbReference type="OMA" id="GQEPFHS"/>
    <dbReference type="OrthoDB" id="5988104at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18077">
        <property type="entry name" value="DEXXQc_HELZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000419">
        <property type="entry name" value="Probable helicase with zinc finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000453">
        <property type="entry name" value="Probable helicase with zinc finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000009">
        <property type="entry name" value="probable helicase with zinc finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049569">
        <property type="entry name" value="HELZ_DEAD-box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF365">
        <property type="entry name" value="HELICASE WITH ZINC FINGER DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1115"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1159"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1247"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1386"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1452"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1595"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1742"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1881"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1115"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1170"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1267"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1291"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1386"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1595"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1636"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1744"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1817"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1888"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1940"/>
            <end position="1955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV99146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027281648.1"/>
        </source>
    </evidence>
    <sequence length="1955" mass="218985" checksum="2B8C7A7F517E6BD7" modified="2011-11-16" version="1">MEDRRAEKSCEEACESLKRQDYDMALQHCTEALLSLGQHSMADAAGPCPSETERIKIESLLYRIASFLQLKNYGQADEDCRHVLGEGLAKGEGAFRAVLCCMQLQGKLQLVSSILAKSLSGESLNGMVTKDLTRLKTLLTETETASNVLPGCHVEDLDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMSSLSPEKVLSECIEGVQVEHNPDLSVTVNTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKANYQSRLHDLLYIEEIAQYKEVSKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKEKLVQTQGTKEKVYEATIEEKTKDYIFLRISRECCEELNLRPDCDAQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDTSMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISGAHSTFQMPQKEDVLKHRVVVVTLNTSQYLCQLDLDPGFFTHILLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSVGRCRKFWERFIALCHENHSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGNSSRQQQSPPKGKGLHHPQSDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPSLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHPAAMAYNMNLLHTHGRGSPIPYGLGHHPPVNIGQPQNQHTEKDQQEQNRNSKTDTNNPGPEINKIRTPEKRPTEPKQVDLESNPQNRSPESRPSIVYSNSKFPRKDNLNPRHINLPLPAPHAQYAIPSRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQVAPQPNQVAPQPNHVAPQPNQVVQQQSQVPPQAPQPSPQLSPAFQAGPTNALFNNAVAHRPQSPAAEAVVPEQQPTPVLPDGHSPLRAITQPAPILASPLNNFVDESSPGLPVGEALDGVHGGVALETLRQQQARLQHWSEHRAYLSQGSIPYPHHHHPHLPHLPQPAMGLPQPPGRAEWKLASRVDDDAETTFSRFQDLLRELSHRDQGDTRELAEMPPPQSRLLQYRQVQTRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVANSPAFPQRLPPQLFGSPFSLPSEHLAPPPLKYLAPDGAWNFANLQQNHLIGPGFPYGLPPLPPRPPQNPFLHIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSAQPCVEEASTPQGSLAQGKELQDHSRPPAFSYPAPESWANTTSSAPYQNIPCNGPSRTAQPRELIAPPKTVKPAEDQLKPDSSEVSSSFNYTVLQHLGQFPPLMPNKQIAESANSSSQQSPAGSKPAMSYASALRAPPKPRPPPEQAKKGSDPLSLFQELSLGSSPGSNGFYSYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3HD29</accession>
    <name>G3HD29_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclosome subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17 18 19 20 21" type="primary">Anapc13</name>
        <name evidence="13" type="ORF">I79_008403</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000287">
        <property type="protein sequence ID" value="EGW05616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003501994.1">
        <property type="nucleotide sequence ID" value="XM_003501946.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640764.1">
        <property type="nucleotide sequence ID" value="XM_007642574.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640765.1">
        <property type="nucleotide sequence ID" value="XM_007642575.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640766.1">
        <property type="nucleotide sequence ID" value="XM_007642576.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270116.1">
        <property type="nucleotide sequence ID" value="XM_027414315.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270117.1">
        <property type="nucleotide sequence ID" value="XM_027414316.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270118.1">
        <property type="nucleotide sequence ID" value="XM_027414317.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270119.1">
        <property type="nucleotide sequence ID" value="XM_027414318.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270120.1">
        <property type="nucleotide sequence ID" value="XM_027414319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HD29"/>
    <dbReference type="STRING" id="10029.G3HD29"/>
    <dbReference type="PaxDb" id="10029-XP_007616562.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009367.1">
        <property type="protein sequence ID" value="ENSCGRP00001006020.1"/>
        <property type="gene ID" value="ENSCGRG00001008030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770713"/>
    <dbReference type="KEGG" id="cge:100770713"/>
    <dbReference type="CTD" id="25847"/>
    <dbReference type="eggNOG" id="ENOG502S4J1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008673"/>
    <dbReference type="OMA" id="PHDDIAV"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141198">
        <property type="term" value="P:protein branched polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW05616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027270116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027270117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027270118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027270119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027270120.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8392" checksum="E84F13B53821CB3B" modified="2011-11-16" version="1">MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLSELPEPEQDNGGTTESVKEQEMKWTDLALQCLHENVPPAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3HHT5</accession>
    <name>G3HHT5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytohesin-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Cytip</name>
        <name evidence="11" type="ORF">I79_010195</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with CYTH1 and SNX27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGV98571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="PDZ_tamalin_CYTIP-like"/>
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    </dbReference>
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        <property type="entry name" value="Cytohesin-interacting protein isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
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    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963:SF1">
        <property type="entry name" value="CYTOHESIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963">
        <property type="entry name" value="GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="166"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <dbReference type="ARBA" id="ARBA00023054"/>
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            <dbReference type="EMBL" id="EGV98571.1"/>
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    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000592">
        <property type="protein sequence ID" value="EGV96129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505651.1">
        <property type="nucleotide sequence ID" value="XM_003505603.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265287.1">
        <property type="nucleotide sequence ID" value="XM_027409486.1"/>
    </dbReference>
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    <dbReference type="STRING" id="10029.G3HPW5"/>
    <dbReference type="PaxDb" id="10029-XP_007620825.1"/>
    <dbReference type="GeneID" id="100763311"/>
    <dbReference type="KEGG" id="cge:100763311"/>
    <dbReference type="eggNOG" id="ENOG502SI2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HPW5"/>
    <dbReference type="OMA" id="QMLVNLC"/>
    <dbReference type="OrthoDB" id="5950740at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tmA_OR2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000005">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
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        <source>
            <dbReference type="RuleBase" id="RU363047"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV96129.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027265287.1"/>
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    <sequence length="313" mass="35565" checksum="BE244ADB92E065BB" modified="2011-11-16" version="1">MSWANESIIEEFVLLGFSDQPWLEFPLFVVFLTSYIVTIFGNFNIILVSRLDPKLHTPMYFFLTNLSVIDLCYITCTVPQLLVNLRSMRKVISYGGCIVQLYMFLALGATECVLLPVMSLDRFVAICRPLHYSVIMHQRFCLQLAAVSWIIGFGNSVWLSILTLQLPRCGHYVIDHFLCEVPAMLKLSCVDTTINDTELFFVSVIFHLVPLTLILISYAFIAQAILKIQSAEGRQKAFGTCGSHLIVVSLFYGTAISMYLIPPSPYSKDPKKMVSLVYGIIAPMMNPLIYTLRNKEVKEAFKRLVKRVFLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3HR58</accession>
    <name>G3HR58_CRIGR</name>
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        <recommendedName>
            <fullName evidence="13">Peripherin-2</fullName>
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        <alternativeName>
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    </protein>
    <gene>
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        <name evidence="18" type="ORF">H671_1g1502</name>
        <name evidence="17" type="ORF">I79_013321</name>
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    <organism evidence="17 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PRPH2/ROM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000627">
        <property type="protein sequence ID" value="EGW06822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE663889">
        <property type="protein sequence ID" value="ERE90619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506098.1">
        <property type="nucleotide sequence ID" value="XM_003506050.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244908.1">
        <property type="nucleotide sequence ID" value="XM_027389107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HR58"/>
    <dbReference type="STRING" id="10029.G3HR58"/>
    <dbReference type="PaxDb" id="10029-XP_007617788.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021798.1">
        <property type="protein sequence ID" value="ENSCGRP00001017554.1"/>
        <property type="gene ID" value="ENSCGRG00001017570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768436"/>
    <dbReference type="KEGG" id="cge:100768436"/>
    <dbReference type="CTD" id="5961"/>
    <dbReference type="eggNOG" id="KOG3882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157303"/>
    <dbReference type="OMA" id="LCCFLMR"/>
    <dbReference type="OrthoDB" id="9836210at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035845">
        <property type="term" value="P:photoreceptor cell outer segment organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051291">
        <property type="term" value="P:protein heterooligomerization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051260">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03162">
        <property type="entry name" value="peripherin_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000002">
        <property type="entry name" value="Retinal outer segment membrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000830">
        <property type="entry name" value="Peripherin/rom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018498">
        <property type="entry name" value="Peripherin/rom-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042026">
        <property type="entry name" value="Peripherin_LEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF202">
        <property type="entry name" value="PERIPHERIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00218">
        <property type="entry name" value="PERIPHERNRDS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00930">
        <property type="entry name" value="RDS_ROM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW06822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ERE90619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027244908.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39251" checksum="12BA878A9989C152" modified="2011-11-16" version="1">MALLKVKFDQKKRVKLAQGLWLMNWLSVLAGIVLFSLGLFLKIELRKRSEVMNNSESHFIPNSLIVVGVLSCVFNSLAGKICYDALDPAKYAKWKPWLKPYLAVCVLFNAVLFLVALCCFLLRGSLESTLAYGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSCCNPSSPRPCIQYQLTNNSAHYSYDHQTEELNLWLRGCRAALLSYYSSLMNSMGVVTLLVWLFEVSITAGLRYLHTALESVSNPEDPAECESEGWLLEKSVPETWKAFLESIKKLGKGNQVEAEGAEAGQAPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3HRH7</accession>
    <name>G3HRH7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Palmitoyltransferase</fullName>
            <ecNumber evidence="14">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Zdhhc5</name>
        <name evidence="17" type="ORF">I79_013448</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="14"/>
    <dbReference type="EMBL" id="JH000637">
        <property type="protein sequence ID" value="EGW09617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506200.1">
        <property type="nucleotide sequence ID" value="XM_003506152.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278478.1">
        <property type="nucleotide sequence ID" value="XM_027422677.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HRH7"/>
    <dbReference type="STRING" id="10029.G3HRH7"/>
    <dbReference type="GlyGen" id="G3HRH7">
        <property type="glycosylation" value="3 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007626164.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008471.1">
        <property type="protein sequence ID" value="ENSCGRP00001005498.1"/>
        <property type="gene ID" value="ENSCGRG00001007216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755578"/>
    <dbReference type="KEGG" id="cge:100755578"/>
    <dbReference type="CTD" id="25921"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156001"/>
    <dbReference type="OMA" id="KMTRGES"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015908">
        <property type="term" value="P:fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044546">
        <property type="term" value="P:NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160075">
        <property type="term" value="P:non-canonical inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070427">
        <property type="term" value="P:nucleotide-binding oligomerization domain containing 1 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070431">
        <property type="term" value="P:nucleotide-binding oligomerization domain containing 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900227">
        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905171">
        <property type="term" value="P:positive regulation of protein localization to phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140639">
        <property type="term" value="P:positive regulation of pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141201">
        <property type="term" value="P:pyroptotic cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032495">
        <property type="term" value="P:response to muramyl dipeptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF3">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="16">
        <location>
            <begin position="102"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027278478.1"/>
        </source>
    </evidence>
    <sequence length="715" mass="77568" checksum="F9B6E759BD37DB93" modified="2011-11-16" version="1">MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPELSLDVSPAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPRKEKTIVIRPPFIRPDVSDGQITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLSLATNEDSSLLGKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIADSSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQQREAERHPRLVPTGPPHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLAGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLSKTPLGRPAVPRFGKPDGLRGRGLGSPEPGPTAPYLGRSMSYSSQKAPPGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSIGSASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV</sequence>
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        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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            <end position="130"/>
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            <end position="29"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10260"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001946">
        <property type="protein sequence ID" value="EGW13578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE673552">
        <property type="protein sequence ID" value="ERE77208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512697.1">
        <property type="nucleotide sequence ID" value="XM_003512649.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260811.1">
        <property type="nucleotide sequence ID" value="XM_027405010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ICR3"/>
    <dbReference type="STRING" id="10029.G3ICR3"/>
    <dbReference type="PaxDb" id="10029-XP_007635539.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009261.1">
        <property type="protein sequence ID" value="ENSCGRP00001005960.1"/>
        <property type="gene ID" value="ENSCGRG00001007940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755416"/>
    <dbReference type="KEGG" id="cge:100755416"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MMWENWT"/>
    <dbReference type="OrthoDB" id="9975554at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="42"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW13578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE77208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027260811.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35623" checksum="E0256406AC65D08E" modified="2011-11-16" version="1">MTWGNWTTVREFILVSFSTLSYELQALLFLLFLIIYLVTLMGNVLIILVTTTDSALQSPMYFFLRNLAFLEIGFNLVIVPKMLATLILQDKSISFLGCATQMYFFFFFGAAECCLLATMAYDRYIAICDPLRYPVIMSRKSCAQLAAASWFAGFPVATVQTTWIFSFPFCGPNRVNHFFCDSPPVIALVCADTSLFELEALTATVLFILFPFLLILGSYVRILSTIFRMPSAEGKHKAFSTCSSHLLVVSLFYTTAILMYFRPRSNTSPEHKKMVSLSYTVVTPMLNPIIYSLRNNEVKAALRRVIGRTLSPRKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-11-01" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>P23174</accession>
    <name>MDR3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylcholine translocator ABCB4</fullName>
            <ecNumber evidence="3">7.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATP-binding cassette sub-family B member 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Multidrug resistance protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">P-glycoprotein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ABCB4</name>
        <name evidence="4" type="synonym">PGP3</name>
        <name type="synonym">PGY3</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="DNA Seq." volume="2" first="89" last="101">
            <title>Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family.</title>
            <authorList>
                <person name="Endicott J.A."/>
                <person name="Sarangi F."/>
                <person name="Ling V."/>
            </authorList>
            <dbReference type="PubMed" id="1685679"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66272"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66273"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:36440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38903"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:38904"/>
        </physiologicalReaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">Translocation activity is inhibited by the ATPase inhibitor vanadate and the calcium channel blocker verapamil. Translocation activity is enhanced by the addition of the bile salt taurocholate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Interacts with HAX1. May interact with RACK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <text evidence="2 3">Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules. Localized preferentially in lipid nonraft domains of canalicular plasma membranes. Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner. Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Phosphorylated. Phosphorylation is required for PC efflux activity. Phosphorylation occurs on serine and threonine residues in a protein kinase A- or C-dependent manner. May be phosphorylated on Thr-44 and Ser-49.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="M60042">
        <property type="protein sequence ID" value="AAA68885.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="I48120">
        <property type="entry name" value="I48120"/>
    </dbReference>
    <dbReference type="PIR" id="I48123">
        <property type="entry name" value="I48123"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001230916.1">
        <property type="nucleotide sequence ID" value="NM_001243987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P23174"/>
    <dbReference type="SMR" id="P23174"/>
    <dbReference type="GlyCosmos" id="P23174">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-NP_001230916.1"/>
    <dbReference type="GeneID" id="100682535"/>
    <dbReference type="KEGG" id="cge:100682535"/>
    <dbReference type="CTD" id="5244"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032782">
        <property type="term" value="P:bile acid secretion"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903413">
        <property type="term" value="P:cellular response to bile acid"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032376">
        <property type="term" value="P:positive regulation of cholesterol transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061092">
        <property type="term" value="P:positive regulation of phospholipid translocation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001140">
        <property type="term" value="P:positive regulation of phospholipid transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901557">
        <property type="term" value="P:response to fenofibrate"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000043">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000083">
        <property type="entry name" value="phosphatidylcholine translocator ABCB4 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF28">
        <property type="entry name" value="ATP-BINDING CASSETTE SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000093341" description="Phosphatidylcholine translocator ABCB4">
        <location>
            <begin position="1"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
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            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
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            <begin position="211"/>
            <end position="217"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
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            <begin position="239"/>
            <end position="296"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
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            <begin position="355"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="758"/>
            <end position="778"/>
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    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
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            <begin position="779"/>
            <end position="833"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="834"/>
            <end position="854"/>
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    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <position position="855"/>
        </location>
    </feature>
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            <begin position="856"/>
            <end position="875"/>
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    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
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            <end position="937"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="959"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="975"/>
            <end position="996"/>
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    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 1" evidence="7">
        <location>
            <begin position="57"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="6">
        <location>
            <begin position="394"/>
            <end position="630"/>
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    </feature>
    <feature type="domain" description="ABC transmembrane type-1 2" evidence="7">
        <location>
            <begin position="713"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with HAX1" evidence="1">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 6">
        <location>
            <begin position="432"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        </ligand>
    </feature>
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        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <position position="536"/>
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        <ligand>
            <name>ATP</name>
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            <position position="1048"/>
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            <name>ATP</name>
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            <end position="1079"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="1119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 6">
        <location>
            <begin position="1179"/>
            <end position="1181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="3">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P21439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P21440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q08201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5"/>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <sequence length="1281" mass="140866" checksum="2203EF61EBB29602" modified="1991-11-01" version="1">MDLEAARNGTARRPGTVEGDFELGSISNQGRNKKKKVNLIGPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVNNAGNFSLPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQKEGVYFKLVNMQTSGSQILSQEFEVELSEEKAADGMTPNGWKSHIFRNSTKKSLKSSRAHHHRLDVDADELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPGDDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQAGAQNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-31" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q9R1F8</accession>
    <name>TLR2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Toll-like receptor 2</fullName>
        </recommendedName>
        <cdAntigenName>CD282</cdAntigenName>
    </protein>
    <gene>
        <name type="primary">TLR2</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="J. Immunol." volume="162" first="6971" last="6975">
            <title>Cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin.</title>
            <authorList>
                <person name="Heine H."/>
                <person name="Kirschning C.J."/>
                <person name="Lien E."/>
                <person name="Monks B.G."/>
                <person name="Rothe M."/>
                <person name="Golenbock D.T."/>
            </authorList>
            <dbReference type="PubMed" id="10358136"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Ovarian carcinoma</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Phagosome membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane raft</location>
        </subcellularLocation>
        <text evidence="3">Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The ATG16L1-binding motif mediates interaction with ATG16L1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2 7">In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAD46477" version="1"/>
        </conflict>
        <text>A natural deletion may however lead to truncated protein which lacks transmembrane or intracellular domain.</text>
    </comment>
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        <property type="protein sequence ID" value="AAD46477.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="mRNA"/>
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    <dbReference type="AlphaFoldDB" id="Q9R1F8"/>
    <dbReference type="SMR" id="Q9R1F8"/>
    <dbReference type="GlyCosmos" id="Q9R1F8">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007635375.1"/>
    <dbReference type="eggNOG" id="KOG4641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042497">
        <property type="term" value="F:triacyl lipopeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071726">
        <property type="term" value="P:cellular response to diacyl bacterial lipopeptide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
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        <property type="term" value="P:cellular response to triacyl bacterial lipopeptide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032680">
        <property type="term" value="P:regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000046">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF17">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0391">Immunity</keyword>
    <keyword id="KW-0395">Inflammatory response</keyword>
    <keyword id="KW-0399">Innate immunity</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0433">Leucine-rich repeat</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0675">Receptor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000034709" description="Toll-like receptor 2">
        <location>
            <begin position="25"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="5">
        <location>
            <begin position="25"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="610"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 3">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 4">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 8">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 9">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 10">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 11">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 12">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 13">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 14">
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            <begin position="389"/>
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        </location>
    </feature>
    <feature type="repeat" description="LRR 15">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 16">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 17">
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            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 18">
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            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 19">
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            <begin position="501"/>
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        </location>
    </feature>
    <feature type="domain" description="LRRCT">
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            <begin position="525"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="6">
        <location>
            <begin position="639"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="ATG16L1-binding motif">
        <location>
            <begin position="761"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with bacterial lipopeptide" evidence="1">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
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            <position position="147"/>
        </location>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
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            <position position="414"/>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
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            <position position="442"/>
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            <begin position="30"/>
            <end position="36"/>
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            <begin position="353"/>
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    <feature type="disulfide bond" evidence="1">
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            <begin position="432"/>
            <end position="454"/>
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    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="3">
        <location>
            <position position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O00206"/>
        </source>
    </evidence>
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            <dbReference type="UniProtKB" id="O60603"/>
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    <evidence type="ECO:0000255" key="5"/>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00204"/>
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    </evidence>
    <evidence type="ECO:0000305" key="7"/>
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</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I6B9</accession>
    <name>A0A061I6B9_CRIGR</name>
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        <recommendedName>
            <fullName evidence="3 11">Tuftelin-interacting protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name evidence="14" type="ORF">H671_4g11555</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE673946">
        <property type="protein sequence ID" value="ERE76805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271723.1">
        <property type="nucleotide sequence ID" value="XM_027415922.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271724.1">
        <property type="nucleotide sequence ID" value="XM_027415923.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271725.1">
        <property type="nucleotide sequence ID" value="XM_027415924.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271726.1">
        <property type="nucleotide sequence ID" value="XM_027415925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I6B9"/>
    <dbReference type="GeneID" id="100774688"/>
    <dbReference type="KEGG" id="cge:100774688"/>
    <dbReference type="CTD" id="24144"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024933">
        <property type="entry name" value="TFP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017706">
        <property type="entry name" value="TFIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0091">Biomineralization</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="13">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE76805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027271723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027271724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027271725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027271726.1"/>
        </source>
    </evidence>
    <sequence length="837" mass="96094" checksum="F322DF057CC847C1" modified="2014-09-03" version="1">MSLSHLYRDGEGHLDDDDDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAEHDSDEERPSFGGKRARDYSAPVNFISAGLKKGAAEEADSDDSDDDEKPAKQEDFPKDLGPKKLKTGGNFKPSQKGFAGGTKSFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSLQDFPVADSEEEAEEEFQKELSQWRKDPSGSKKKPKYSYKTVEELKAKGRVSKKLTAPQKELSQVKVIDMTGREQKVYYSYSQISHKHSVPDEGLPLLAQLPPTAGKEAKVPGFALPELEHNLQLLIERTEQEIIQSDRQLQYERDMVVSLSHELEKTAEVLAHEERVISNLSKVLALVEECERRMQPHGTDPLTLDECAHIFETLQDKYYEEYRLADRADLAVAIVYPLVKDYFKDWHPLEDGSYGTQIISKWKSLLENDQLLSHSSQDLSSDAFHRLMWEVWMPFVRNVVAQWQPRNCDPMVDFLDSWAHIIPVWILDNILDQLIFPKLQKEVDNWNPLTDTVPIHSWIHPWLPLMQARLEPLYSPVRSKLSSALQKWHPSDASAKLILQPWKEVLTPGSWEAFMLRNIVPKLGMCLGELVINPHQQHMDAFYWVMDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQRGIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEGKQLYTFGRIVIYIDRGVVFVQGEKTWVPTSLQSLIDMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IRE0</accession>
    <name>A0A061IRE0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8 12">GAS2-like protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Growth arrest-specific 2 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Gas2l1</name>
        <name evidence="8" type="ORF">H671_1g1183</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Stress fiber</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE663652">
        <property type="protein sequence ID" value="ERE91110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016832567.1">
        <property type="nucleotide sequence ID" value="XM_016977078.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243158.2">
        <property type="nucleotide sequence ID" value="XM_027387357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IRE0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000582.1">
        <property type="protein sequence ID" value="ENSCGRP00001000558.1"/>
        <property type="gene ID" value="ENSCGRG00001000451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773328"/>
    <dbReference type="KEGG" id="cge:100773328"/>
    <dbReference type="CTD" id="10634"/>
    <dbReference type="OrthoDB" id="206130at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904825">
        <property type="term" value="P:protein localization to microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21268">
        <property type="entry name" value="CH_GAS2L1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.20:FF:000004">
        <property type="entry name" value="GAS2-like protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000047">
        <property type="entry name" value="Growth arrest specific 2 like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF16">
        <property type="entry name" value="GAS2-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="203"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ERE91110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027243158.2"/>
        </source>
    </evidence>
    <sequence length="678" mass="72146" checksum="FA0E76D2AA5DADE0" modified="2014-09-03" version="1">MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLADWLNALYGLGLPGSGDGFLTGLATGTALCQHANAVTEAARALAAVRPTRGVAFQAHSVAPGSFMARDNVATFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIEQELRDTPQVSSVPAAEEDATEIVTVSGAPTRTPRMTPNDLRNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSSTAHRLPPQRAGTFSPQRGSPTPSPRPGSPVPGSERRGSRPEVTPISLRSTKEGPEVPLSLRPRDQLPPLPRSRRYSGDSDSSASSAQSGPPGARSDDAATGSRRERPSHRLTSGLPASPRRPPTPRSQSRDRLDRERSRLAPGGRGAQLSASSPVRRARSQSREEQAVLMVRRDRDGQHACVARGRGGGGSGGSGRSTPQTPRARSPAAPRPSRGPSPSLELATTPASLFRTPLQLDPQQEQQLYQRLEEEFLANARALKAAASHTSMGPAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGESGRTANGLPAPRSQALSSSSDEGSPCLAIGGPLDATKSSLTGPEPSLTLARGRMDTQPDRKPSRIPTPRGPRRPSGPMELGAWHALQSGTPRTQPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7GPA7</accession>
    <name>A0A3L7GPA7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly factor IBA57, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Iba57</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial protein involved in the maturation of mitochondrial [4Fe-4S]-proteins in the late stage of the iron-sulfur cluster assembly pathway. Operates in cooperation with ISCA2 in the maturation of [4Fe-4S] proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283160.1">
        <property type="nucleotide sequence ID" value="XM_027427359.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7GPA7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008749.1">
        <property type="protein sequence ID" value="ENSCGRP00001005662.1"/>
        <property type="gene ID" value="ENSCGRG00001007484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763588"/>
    <dbReference type="KEGG" id="cge:100763588"/>
    <dbReference type="CTD" id="200205"/>
    <dbReference type="GeneTree" id="ENSGT00390000006465"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000015">
        <property type="entry name" value="IBA57, iron-sulfur cluster assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="9">
        <location>
            <begin position="277"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027283160.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="38708" checksum="1ADC6982226661C4" modified="2019-02-13" version="1">MAVAALLRGAAAGRGSPAWSWRQSWIPKCCSVRGSGLLGGNPKDGAAWTCFRLDERALVRVRGPDAAPFLLGLLTNELPLSGPPTGAAQPSARAAYAHFLNVQGRTLYDVILYGLPESTKEAPGFLLECDSSALDTLQKHLAMYKIRRKVTVEPHPELHVWAVLPCDPQTPEAAPLEERVETTTILTRDPRTVRMGWRLLIQDDGPALVPRGQLGDIQDYHMHRYQQGIPEGICDLPPGMALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVRLEGPLPASGISPGTLVMVTATGQAAGKFRAGQGCVGLALLRSETIKGPLHIKTSESQQVAVTALVPDWWPTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HT91</accession>
    <name>A0A3L7HT91_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secretogranin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Secretogranin III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Scg3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003495059.1">
        <property type="nucleotide sequence ID" value="XM_003495011.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266934.1">
        <property type="nucleotide sequence ID" value="XM_027411133.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HT91"/>
    <dbReference type="Ensembl" id="ENSCGRT00001004376.1">
        <property type="protein sequence ID" value="ENSCGRP00001003104.1"/>
        <property type="gene ID" value="ENSCGRG00001003651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763721"/>
    <dbReference type="KEGG" id="cge:100763721"/>
    <dbReference type="CTD" id="29106"/>
    <dbReference type="GeneTree" id="ENSGT00390000005488"/>
    <dbReference type="OMA" id="TDKAIHN"/>
    <dbReference type="OrthoDB" id="9941750at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033366">
        <property type="term" value="P:protein localization to secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026197">
        <property type="entry name" value="SCG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17388">
        <property type="entry name" value="SECRETOGRANIN III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17388:SF2">
        <property type="entry name" value="SECRETOGRANIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15467">
        <property type="entry name" value="SGIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594416" description="Secretogranin-3" evidence="12">
        <location>
            <begin position="23"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027266934.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53429" checksum="03977896DCE7A661" modified="2019-02-13" version="1">MEFLWTGSWILVLVLNSVPIQAFPKPEVSQDKSLHNRELSAERPLNEQIAEAEADKIKKTYPPESKSSESNYSSIDNLNLLRAITEKEKLEKEKQSIRSSPFGNKLNAEDVDSTKNRKLIDEYDSTKSSLDHKFQDDPDGLHQLDGTPLTAEDIVHKIATRIYEENDRGVFDKIVSKLLNLGLITESQAHTLEDEVAEALQKLISKEANNYEEALDKPTSRTEYQAGKIPEKVTPVAAIQDGFTNRENDETVSNTLTLSNGLERRTKPHSEDDFEELQYFPNFYALLTSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEAIALQTKNKLEKNSTDSKSKLSPVPSEKSHEETDSTKEEAAKMEKEYGTLKDSTKDDNSNLGGKTDQAKGKTEAYLEAIRKNIEWLKKHNKKGNKEDYDLSKMRDFINQQADAYVEKGILDKEEAKAIKRIYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I473</accession>
    <name>A0A3L7I473_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Forkhead box D2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Forkhead box protein D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">LOC113834312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027258283.1">
        <property type="nucleotide sequence ID" value="XM_027402482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I473"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012263.1">
        <property type="protein sequence ID" value="ENSCGRP00001008153.1"/>
        <property type="gene ID" value="ENSCGRG00001010484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113834312"/>
    <dbReference type="KEGG" id="cge:113834312"/>
    <dbReference type="GeneTree" id="ENSGT00940000157140"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20046">
        <property type="entry name" value="FH_FOXD1_D2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF373">
        <property type="entry name" value="FORKHEAD BOX PROTEIN D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="129"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="129"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027258283.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="48896" checksum="7862075EBB3DC2C1" modified="2019-02-13" version="1">MTLGSCCCEIMSSESSPAALSEPDADIDVVGGGSGGGELTVRSGPRAPRDVLPHGHEPPPEEAEADVAEDEEESGGCSDCEPRALAPRGAAAAAGSPGPGVQAARGTAGPGPGPGPPSGGAATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYGAPPPGPAPHPHPHPHAFAFAATAPCQLSVPPGRAAAPPPGPPTASVFASAASAPAPAPAPGSGPGPAGLPAFLGAELGCAKAFYPASLSPPAAGTAASLSTALLRQGLKTDAGGGAGGGGAGAGQRPSFSIDHIMGHGGGGGAAPPGSGDGSPGSPFAAAAGPGGQAQVLAMLTAPALAPVAGHIRLSHPGDALLSSGPSFASKVAGLSGCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I800</accession>
    <name>A0A3L7I800_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myotilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Myofibrillar titin-like Ig domains protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Titin immunoglobulin domain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Myot</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the myotilin/palladin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294932.1">
        <property type="nucleotide sequence ID" value="XM_035439041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I800"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022674.1">
        <property type="protein sequence ID" value="ENSCGRP00001018430.1"/>
        <property type="gene ID" value="ENSCGRG00001018181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772758"/>
    <dbReference type="KEGG" id="cge:100772758"/>
    <dbReference type="CTD" id="9499"/>
    <dbReference type="OrthoDB" id="6612025at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05892">
        <property type="entry name" value="IgI_Myotilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000694">
        <property type="entry name" value="Myotilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000702">
        <property type="entry name" value="Myotilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF23">
        <property type="entry name" value="MYOTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="248"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="347"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035294932.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55281" checksum="FE97472FA95A28BE" modified="2019-02-13" version="1">MFNYERPKHFIQSQNPCGSRLQPPGPETSSFPSQTKQSSIVIQPRQCTEQRFSASSTVSSHITVSSSAYPASQQLAGPNPAQKVTASYNQSPASFLSSILPSQPDYISSKIPSTVDSNYQQSSVNQPVNAMPSPTANAKTTPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQNSDAQDSPQHNPEHARLQVPTSQVRSRSSSRAEANDQDAIQEKFYPPRFIQVPENMSIEEGRFCRMDFKVSGLPAPDVSWYLNGRAVQSDELHKMIVSEKGFHSLIFEVVRTSDAGSYACVARNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVFEGESVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYHDNSGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLDVKQAFNPEGEFQRLAAQSGLYESEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IE67</accession>
    <name>A0A3L7IE67_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cofactor required for Sp1 transcriptional activation subunit 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Med26</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027250670.1">
        <property type="nucleotide sequence ID" value="XM_027394869.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IE67"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006523.1">
        <property type="protein sequence ID" value="ENSCGRP00001004359.1"/>
        <property type="gene ID" value="ENSCGRG00001005532.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755356"/>
    <dbReference type="KEGG" id="cge:100755356"/>
    <dbReference type="CTD" id="9441"/>
    <dbReference type="GeneTree" id="ENSGT00390000000259"/>
    <dbReference type="OrthoDB" id="550309at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mediator of RNA polymerase II transcription subunit 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MED26"/>
    </dbReference>
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        <property type="entry name" value="Med26_C"/>
    </dbReference>
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        <property type="entry name" value="Med26_Mid"/>
    </dbReference>
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        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
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    <dbReference type="PANTHER" id="PTHR15201">
        <property type="entry name" value="CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
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    </dbReference>
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        <property type="entry name" value="Med26_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15694">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="14">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="102"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="409"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030125"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00031968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057523"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00062177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027250670.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="64205" checksum="729C34349A2F5855" modified="2019-02-13" version="1">MTAAPASPQQMRDRLLQAIDSQSNIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLIEPVHQNEVALRALAGAAGSANGGAHNCRSEVGVASTPKSIHDLKNRNDIQRLPGERLDRLGSRKRRGDQRDLGHPGPPHKVPKATPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDSSRLEPSDNEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLDRADEPPGPPHPRGTSRCSFSPRNSRHEGSFARQRSSYIAKGSVSSPSPRPQPLDTTQVPSPLPLAQPSTPPVRRMELLSSAESPVHWPEQPEGHPRLTGPACRVGLSPDSSKVDSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVPTEQPPRTEQDQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEESSRRGARQPHVLLPLPTPTDLPGLTREITQDDLDRIQAQKWPGVNGCEDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IHB9</accession>
    <name>A0A3L7IHB9_CRIGR</name>
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        <submittedName>
            <fullName evidence="2">Leucine rich repeat containing 34</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Lrrc34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035306628.1">
        <property type="nucleotide sequence ID" value="XM_035450737.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312467.1">
        <property type="nucleotide sequence ID" value="XM_035456576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IHB9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013397.1">
        <property type="protein sequence ID" value="ENSCGRP00001009210.1"/>
        <property type="gene ID" value="ENSCGRG00001011347.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767765"/>
    <dbReference type="KEGG" id="cge:100767765"/>
    <dbReference type="CTD" id="151827"/>
    <dbReference type="OMA" id="IKNCGMK"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035306628.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46888" checksum="D871ED924AFB5969" modified="2019-02-13" version="1">MDKLQVQYCHFCSENLRETNPFVLNILKDLDEEITEKPEKEIILNIAGNNRLRKVQRLTGEDFWLLSKVLRNRSLIIGLDVRYNLISDVGAYYAAKLLQKQPHLTYLNLMFNDIGPDGGELIAKALHKNRTLKYLRMTGNKIENTGGMVFAAMLQINSSLEKLDLGDCDLGLQSVIAFSTVLTQNQAIKGINLNRPILYGEQEESTVHMGHMLKENHFLVELHLCKHDMKNFGMQQLCNALYLNSSLRYLDVSCNKITRDGMVYLADVLKSNTTLEVIDLSFNRIENAGAKYLSETLTSHNRSLKALSVVSNKIEGEGLVALSQSMKTNLILSNIYIWGNKFDEATCVAYSDLMKSGRLNPDNTDVEPYEVDGHVYLAEVSNGLKRHYYWTPTYGNPYDYSSSAGFALVPVGQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IJ87</accession>
    <name>A0A3L7IJ87_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Glutathione reductase</fullName>
            <ecNumber evidence="21">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Gsr</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16 21">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 21">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="21"/>
    <dbReference type="RefSeq" id="XP_027247076.1">
        <property type="nucleotide sequence ID" value="XM_027391275.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309902.1">
        <property type="nucleotide sequence ID" value="XM_035454011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IJ87"/>
    <dbReference type="SMR" id="A0A3L7IJ87"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030657.1">
        <property type="protein sequence ID" value="ENSCGRP00001026411.1"/>
        <property type="gene ID" value="ENSCGRG00001023740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757970"/>
    <dbReference type="KEGG" id="cge:100757970"/>
    <dbReference type="CTD" id="2936"/>
    <dbReference type="GeneTree" id="ENSGT00940000156986"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000484">
        <property type="entry name" value="Glutathione reductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000671">
        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF5">
        <property type="entry name" value="GLUTATHIONE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 21" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="8 21" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14 20" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="23">
        <location>
            <begin position="41"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="22">
        <location>
            <begin position="387"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="214"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="19">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027247076.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="53738" checksum="4ADFBEE14F3B05B3" modified="2019-02-13" version="1">MALLPRALSVGAAPSLRRVVRALTCAMASTDEVQTPAAVSFDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHMDYGFQNCESKFNWHVIKEKRDAYVSRLNTIYQNNLTKSHIEIIHGYAAFADGPQPTVEVNGKKYTAPHILIATGGVPTVPQESQIPGASLGITSDGFFQLEDLPSRSVIVGAGYIAVEIAGILSALGSKTSLMIRHDKVLRNFDSLISSNCTEELENAGVEVLKFSQVKEVKKTPSGLELLMVTAVPGRKPTTTMIPDVDCLLWAIGRDPNSRGLNLNKLGIQTDEKGHIIVDEFQNTNVKGVYAVGDVCGRALLTPVAIAAGRKLAHRLFECKEDSKLDYDNIPTVVFSHPPIGTVGLTEDEAVHKYGKESVKIYSTTFTPMYHAVTTRKTKCVMKMVCANKEEKVVGIHMQGIGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IP80</accession>
    <name>A0A3L7IP80_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 16">Olfactory receptor 7E24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113832181</name>
        <name evidence="16" type="synonym">LOC113832175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027242310.1">
        <property type="nucleotide sequence ID" value="XM_027386509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IP80"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018773.1">
        <property type="protein sequence ID" value="ENSCGRP00001014536.1"/>
        <property type="gene ID" value="ENSCGRG00001015400.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cge:113832175"/>
    <dbReference type="GeneTree" id="ENSGT00940000156425"/>
    <dbReference type="OrthoDB" id="9523733at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15234">
        <property type="entry name" value="7tmA_OR7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027242310.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34571" checksum="A327D18C997ADB90" modified="2019-02-13" version="1">MRNTTSVPEFHFIQLSEDPDLQPVLFGLFLSMYILALLGNLLIILTVSSDSHLHTPMYFFLSNLSMVDIGFISTTVPRVIVDIQTHCPVISYVGCLTQMSLFIIFACMDDMLLSVMAYDRFVAICHPLYYQVIMNPSRCGVLLIGCFLLSLLELLLHYVAVIKFSNCKDYIEISNFFCDLSEVLKLADFDTFTQNIVRYCVGALFGLLPISGIIFSYYKIVFSIMRSSSSSGKQKTFSTCGSHLSIVCLFYGTGLGVYFSSSLSHSPRSNAVASVMYTVVTPMLNPFIYSLRNKDIKTALRKILSRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LFA4</accession>
    <name>A0A8C2LFA4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-defensin 33</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Defensin beta 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">LOC100766932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003512726.1">
        <property type="nucleotide sequence ID" value="XM_003512678.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245825.1">
        <property type="nucleotide sequence ID" value="XM_027390024.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LFA4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002808.1">
        <property type="protein sequence ID" value="ENSCGRP00001002192.1"/>
        <property type="gene ID" value="ENSCGRG00001002303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766932"/>
    <dbReference type="KEGG" id="cge:100766932"/>
    <dbReference type="GeneTree" id="ENSGT00400000023630"/>
    <dbReference type="OMA" id="FLECEKM"/>
    <dbReference type="OrthoDB" id="9603145at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031731">
        <property type="term" value="F:CCR6 chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20515">
        <property type="entry name" value="BETA-DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20515:SF4">
        <property type="entry name" value="BETA-DEFENSIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678513" evidence="3">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027245825.1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7311" checksum="41611E902732F11C" modified="2022-01-19" version="1">MKLLFLLFLLLICLIQTASGRRRDMRFRQCEKMGGLCKYQKTHGCSILPAECKSRYKHCCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LGS6</accession>
    <name>A0A8C2LGS6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Arylsulfatase G</fullName>
            <ecNumber evidence="11">3.1.6.1</ecNumber>
            <ecNumber evidence="15">3.1.6.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">N-sulfoglucosamine-3-sulfatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22 23" type="primary">Arsg</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23">17A/GY</strain>
            <tissue evidence="22 23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Displays arylsulfatase activity at acidic pH towards the artificial substrate p-nitrocatechol sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.</text>
            <dbReference type="EC" id="3.1.6.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="11"/>
    <dbReference type="EC" id="3.1.6.15" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003500368.1">
        <property type="nucleotide sequence ID" value="XM_003500320.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281612.1">
        <property type="nucleotide sequence ID" value="XM_027425811.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281613.1">
        <property type="nucleotide sequence ID" value="XM_027425812.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LGS6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001877.1">
        <property type="protein sequence ID" value="ENSCGRP00001001645.1"/>
        <property type="gene ID" value="ENSCGRG00001001475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751256"/>
    <dbReference type="KEGG" id="cge:100751256"/>
    <dbReference type="CTD" id="22901"/>
    <dbReference type="GeneTree" id="ENSGT00940000159093"/>
    <dbReference type="OMA" id="HVACRCQ"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033889">
        <property type="term" value="F:N-sulfoglucosamine-3-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048872">
        <property type="term" value="P:homeostasis of number of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16161">
        <property type="entry name" value="ARSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000006">
        <property type="entry name" value="Arylsulfatase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000031">
        <property type="entry name" value="arylsulfatase G isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF42">
        <property type="entry name" value="ARYLSULFATASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="18">
        <location>
            <begin position="36"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027281612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027281613.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="56803" checksum="5D1FBEDE9419E72A" modified="2022-01-19" version="1">MGWLFLKVLLAGMTFSGLLYPLLDLSISGKTRAPKPNIVIILADDMGWGDLGANWAETKDTTNLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGGLPLNETTLAEVLQQAGYVTAMIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNYPPCPACPQSDGLWRNPERDCYTDVALPLYENLNIVEQPVNLSGLARKYLEKAVAFIEQASTSGRPFLLYMGLAHMHVPLSVTPPLENPGSQRPYRASLQEMDSLVGQIKDKVDHMAKENTLLWITGDNGPWAQKCELAGSVGPFFGLWQTHQGGSSAKQTTWEGGHRVPALAYWPGRVPANATSTALLSMLDIFPTAIALAGASLPPNRNFDGLDVSEVLFGRSQVGHRVLFHPNSGAAGEYGGLQTVRLDHHKAFYITGGAKACDGSTGPEQLHASPLIFNLEDDAAEAAPLQRGSPEYQAVLPKVTRVLADVLQDIADDNSSRADYSQDPSVTPCCSPSQIACRCQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LMG0</accession>
    <name>A0A8C2LMG0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rab GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GAP and centrosome-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Rab6 GTPase-activating protein GAPCenA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21 22 23 24 25 26 27" type="primary">Rabgap1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with RAB6A and tubulin gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003504520.1">
        <property type="nucleotide sequence ID" value="XM_003504472.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643202.1">
        <property type="nucleotide sequence ID" value="XM_007645012.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643205.1">
        <property type="nucleotide sequence ID" value="XM_007645015.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016832159.1">
        <property type="nucleotide sequence ID" value="XM_016976670.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016832160.1">
        <property type="nucleotide sequence ID" value="XM_016976671.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279363.1">
        <property type="nucleotide sequence ID" value="XM_027423562.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279364.1">
        <property type="nucleotide sequence ID" value="XM_027423563.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279365.1">
        <property type="nucleotide sequence ID" value="XM_027423564.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279366.1">
        <property type="nucleotide sequence ID" value="XM_027423565.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279367.1">
        <property type="nucleotide sequence ID" value="XM_027423566.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279368.1">
        <property type="nucleotide sequence ID" value="XM_027423567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302891.1">
        <property type="nucleotide sequence ID" value="XM_035447000.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313024.1">
        <property type="nucleotide sequence ID" value="XM_035457133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LMG0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010038.1">
        <property type="protein sequence ID" value="ENSCGRP00001006394.1"/>
        <property type="gene ID" value="ENSCGRG00001008620.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769979"/>
    <dbReference type="KEGG" id="cge:100769979"/>
    <dbReference type="CTD" id="23637"/>
    <dbReference type="GeneTree" id="ENSGT00940000157216"/>
    <dbReference type="OMA" id="AVHQCHV"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01211">
        <property type="entry name" value="PTB_Rab6GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000004">
        <property type="entry name" value="Putative rab gtpase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000125">
        <property type="entry name" value="Putative rab gtpase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000007">
        <property type="entry name" value="Rab GTPase-activating protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF6">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="16">
        <location>
            <begin position="147"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="17">
        <location>
            <begin position="561"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="478"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="795"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="984"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027279363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027279364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027279365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027279366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027279367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027279368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_035302891.1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="120982" checksum="3B5F80C962BA1530" modified="2022-01-19" version="1">MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGERSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEVSSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQISLDVTLSVPNVSEGTVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRTAKQTLLSATASPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVICVQQTANKELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQKERKNNVDTLYEVVCLESESERERRKTTASPSARLPQSGSQSSMIPSPPEDDEEEDNDEPLLSGFGDVSKECAEKILETWGELLSKWHLNLSVRPKQLSSLVRSGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKRLMELACNTKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEDEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCDRCRDFFNKEGRVKGTSSAKEVSDEDMDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALSEVQAAKKTWFNRTLSSIKTATGVQGKETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LNB1</accession>
    <name>A0A8C2LNB1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Signal recognition particle 9 kDa protein</fullName>
            <shortName evidence="10">SRP9</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Srp9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with SRP14; binds RNA as heterodimer. Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SRP9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007639027.1">
        <property type="nucleotide sequence ID" value="XM_007640837.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274601.1">
        <property type="nucleotide sequence ID" value="XM_027418800.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LNB1"/>
    <dbReference type="SMR" id="A0A8C2LNB1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010347.1">
        <property type="protein sequence ID" value="ENSCGRP00001006569.1"/>
        <property type="gene ID" value="ENSCGRG00001008910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103160754"/>
    <dbReference type="KEGG" id="cge:103160754"/>
    <dbReference type="CTD" id="6726"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000001">
        <property type="entry name" value="Signal recognition particle 9 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008832">
        <property type="entry name" value="SRP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017029">
        <property type="entry name" value="Signal_recog_particle_SRP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP9" evidence="11">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027274601.1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10167" checksum="655860497522B8CC" modified="2022-01-19" version="1">MPQFQTWEEFSRAAEKLYLADPMKVRVVLKYRHVDGNLCIKVTDDLVCLVYRTDQAQDVKKIEKFHSQLMRLMVAKESRTVSMETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LTS2</accession>
    <name>A0A8C2LTS2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDK2-associated and cullin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Cacul1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with CDK2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007639085.2">
        <property type="nucleotide sequence ID" value="XM_007640895.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262654.1">
        <property type="nucleotide sequence ID" value="XM_027406853.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LTS2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012218.1">
        <property type="protein sequence ID" value="ENSCGRP00001008112.1"/>
        <property type="gene ID" value="ENSCGRG00001010443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751838"/>
    <dbReference type="KEGG" id="cge:100751838"/>
    <dbReference type="CTD" id="143384"/>
    <dbReference type="OrthoDB" id="8172509at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000028">
        <property type="entry name" value="CDK2-associated and cullin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042652">
        <property type="entry name" value="CACUL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46636">
        <property type="entry name" value="CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46636:SF1">
        <property type="entry name" value="CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="7">
        <location>
            <begin position="128"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027262654.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40286" checksum="9BF89E0B69001F66" modified="2022-01-19" version="1">MEECMEEEEMLTYEAMMDDQNHNNWEAAADNFRQPPPPPPSSSVPDPGRDPPGGSADRKGPKEGLPMGPPPLPEPNGVIMMLKSCDAAAAVTKAAPAPTPSSTININTSTSKFLMNVITVEDYKSTYWPKLDGAIDQLLTQSPGDYIPISYEQIYSCVYKCVCQQHSEQMYSDLIKKITSHLERVSKELQASPPDLYIERFNIALGQYMGALQSIVPLFIYMNKFYIETKLNRDLKDDLIKLFTEHVADKHIYSLMPLLLEAQSTPFQVTPSTMANIVKGLYTLRPEWVQMAPTLFSKFIPNILPPAVESELSEYAAQDQKLQRDLIQNGFTRGDQSRKRAGDELAYNSPSACASSRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LYI4</accession>
    <name>A0A8C2LYI4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15">PHD finger protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Phf23</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PHF23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282765.1">
        <property type="nucleotide sequence ID" value="XM_027426964.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295576.1">
        <property type="nucleotide sequence ID" value="XM_035439685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LYI4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014256.1">
        <property type="protein sequence ID" value="ENSCGRP00001010036.1"/>
        <property type="gene ID" value="ENSCGRG00001012022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762291"/>
    <dbReference type="KEGG" id="cge:100762291"/>
    <dbReference type="CTD" id="79142"/>
    <dbReference type="GeneTree" id="ENSGT00530000063882"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902902">
        <property type="term" value="P:negative regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901097">
        <property type="term" value="P:negative regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15631">
        <property type="entry name" value="PHD_PHF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14571">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14571:SF8">
        <property type="entry name" value="PHD FINGER PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="11">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027282765.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="43780" checksum="203090425ECC549B" modified="2022-01-19" version="1">MLEAMTEPSPEDPPPTLKPETQPPEKRRRTIEDFNKFCSFVLAYAGYIPPSKEESDWPASGSSSPLRGESAADSDGWDSAPSDLRTIQTFVKKAKSSKRRAAQAGPTQPGPPRSTFSRLQAPDSATLLEKMKLKDSLFDLDGPKVASPLSPTSLTHTSRSPAALTPVPLSQGDLSQPRKKDRKNRKLGPGGGTGFGVLRRPRPAPGDGEKRSRIKKSKKRKLKKADRGDRLPPPGPPRAPPSDTDSEEEEEEEEEEDEEEMTAVVGGEVPVSVLPTPPEAPRPPVTVHPEGVPPTDSEGKEVGSTETSQDGDASSSEGEMRVMDEDIMVESGDDSWDLITCYCRKPFAGRPMIECSLCGTWIHLSCAKIKKTNVPDFFYCQKCKELRPEARRLGGLPKSGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M9I3</accession>
    <name>A0A8C2M9I3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Leucine rich repeat containing 52</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">Leucine-rich repeat-containing protein 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Lrrc52</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003505595.1">
        <property type="nucleotide sequence ID" value="XM_003505547.3"/>
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        <property type="nucleotide sequence ID" value="XM_027417100.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C2M9I3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018125.1">
        <property type="protein sequence ID" value="ENSCGRP00001013888.1"/>
        <property type="gene ID" value="ENSCGRG00001014921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761858"/>
    <dbReference type="KEGG" id="cge:100761858"/>
    <dbReference type="CTD" id="440699"/>
    <dbReference type="GeneTree" id="ENSGT00940000156906"/>
    <dbReference type="OMA" id="QDYIFLC"/>
    <dbReference type="OrthoDB" id="4691307at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:transmembrane transporter binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Leucine rich repeat containing 38"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051432">
        <property type="entry name" value="KCNMA1_auxiliary"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473:SF6">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678791" evidence="14">
        <location>
            <begin position="24"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013888.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027272901.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35045" checksum="ED69EF742D22663C" modified="2022-01-19" version="1">MSLASGPGPQLLLFSLGMGLVSGSKCPNNCLCQDQEVFCTNMQLMEYPLDIPLNTRRLFLSNNKITSLPALQLGLLSDLVYLDCQNNRIRELMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVRLNISNNPHLLYLNKYIFANTSSLRHLDLRNTGLQTIDHNALHHLMVLQTLYLSGNPWKCNCSFLDFTIHLLVSEIDQPDGQNATCMEPTELSGWPVAQVGNPLQYMCLTHLDHQDYIFLLLIGFCIFAAGTVAAWLTGVGAVLYQNARRKSGGDDTEDESGNRVTNQIFRSKANFSQGRFPHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MF10</accession>
    <name>A0A8C2MF10_CRIGR</name>
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        <submittedName>
            <fullName evidence="10 13 14">Integrator complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13 14" type="primary">Ints13</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14">17A/GY</strain>
            <tissue evidence="13 14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003508997.1">
        <property type="nucleotide sequence ID" value="XM_003508949.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285907.1">
        <property type="nucleotide sequence ID" value="XM_027430106.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285908.1">
        <property type="nucleotide sequence ID" value="XM_027430107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MF10"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021719.1">
        <property type="protein sequence ID" value="ENSCGRP00001017475.1"/>
        <property type="gene ID" value="ENSCGRG00001017512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757147"/>
    <dbReference type="KEGG" id="cge:100757147"/>
    <dbReference type="CTD" id="55726"/>
    <dbReference type="GeneTree" id="ENSGT00390000002793"/>
    <dbReference type="OrthoDB" id="5844105at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160232">
        <property type="term" value="C:INTAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
        <property type="term" value="P:RNA polymerase II transcription initiation surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027285907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027285908.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="82910" checksum="1918490038078709" modified="2022-01-19" version="1">MRIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTPGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALATVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRPKKELSPVLTSEVHSVRAGRHLATKLNVLVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLRSGDTHSGGSSREGPFKETVTLKWCTPRTNSIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKMDASLEIPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVPLASVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHVSNSEKHQRVLECLMACRSKPPEEEERKKRGRKREDREDKSEQAAKEHGPEKPRPDSDRLKGILERGKEELAEAEVIKDSPDSPEPPNKKPLVEMDETPHMEKSKGPMSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEENGEEVGLTGGPRTSIPFLKCSHSPVVNRMETTENGKASRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MFB6</accession>
    <name>A0A8C2MFB6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyadenylate-binding protein</fullName>
            <shortName evidence="11">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Pabpc4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007643752.2">
        <property type="nucleotide sequence ID" value="XM_007645562.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254985.1">
        <property type="nucleotide sequence ID" value="XM_027399184.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MFB6"/>
    <dbReference type="SMR" id="A0A8C2MFB6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022692.1">
        <property type="protein sequence ID" value="ENSCGRP00001018448.1"/>
        <property type="gene ID" value="ENSCGRG00001018166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751578"/>
    <dbReference type="KEGG" id="cge:100751578"/>
    <dbReference type="CTD" id="8761"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061515">
        <property type="term" value="P:myeloid cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000001">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000021">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000042">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000154">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="294"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="14">
        <location>
            <begin position="566"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027254985.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="72479" checksum="58A48F7EC4CCA95A" modified="2022-01-19" version="1">MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDDNLKELFSQFGKTLSVKVMRDPSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKAIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILSQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPALRHLAPTGNAPASRGLPTTTQRVGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPAAVPSLAPRATVAAAPRAVAPYKYAASVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGVGTVAAAAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MIG0</accession>
    <name>A0A8C2MIG0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">28S ribosomal protein S28, mitochondrial isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Mrps28</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027254579.1">
        <property type="nucleotide sequence ID" value="XM_027398778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MIG0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023481.1">
        <property type="protein sequence ID" value="ENSCGRP00001019237.1"/>
        <property type="gene ID" value="ENSCGRG00001018741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103161031"/>
    <dbReference type="KEGG" id="cge:103161031"/>
    <dbReference type="CTD" id="28957"/>
    <dbReference type="GeneTree" id="ENSGT00390000001057"/>
    <dbReference type="OrthoDB" id="6020229at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019375">
        <property type="entry name" value="Ribosomal_bS1m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10246">
        <property type="entry name" value="MRP-S35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027254579.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20557" checksum="19F49C8F457E70C0" modified="2022-01-19" version="1">MAALCGSHAGAPGSRFLRALLFFKPFRNASTESGSESTTPDSSAPRERSAGFASALERLSELRRKAELGRESPKNVESFASMLRHSPLTQMGPAKDKLVIGRIFHIVEDDLYIDFGGKFHCVCKRPEVDGGKYQRGTRVRLRLLDLELTSRFLGATTDTTLLEADAVLLGLQESRDSKSREEQLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJ88</accession>
    <name>A0A8C2MJ88_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polycystin-2-like protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Polycystic kidney disease 2-like 2 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Polycystin-L2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Pkd2l2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Exhibits a lower single conductance but no spontaneous channel activity. May function as a regulator of calcium channels or a channel component involving Ca2(+) homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with TRPC1 and TRPC5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003502581.1">
        <property type="nucleotide sequence ID" value="XM_003502533.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256507.1">
        <property type="nucleotide sequence ID" value="XM_027400706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MJ88"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024157.1">
        <property type="protein sequence ID" value="ENSCGRP00001019913.1"/>
        <property type="gene ID" value="ENSCGRG00001019213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753206"/>
    <dbReference type="KEGG" id="cge:100753206"/>
    <dbReference type="CTD" id="27039"/>
    <dbReference type="GeneTree" id="ENSGT00940000161122"/>
    <dbReference type="OMA" id="MVDFWKF"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000096">
        <property type="entry name" value="polycystic kidney disease 2-like 2 protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF47">
        <property type="entry name" value="POLYCYSTIN-2-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="19">
        <location>
            <begin position="78"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="18">
        <location>
            <begin position="273"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027256507.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="73690" checksum="4EA8B31146D3C3CD" modified="2022-01-19" version="1">MAEASWWYRGGTSKHDLHYRREAEVNTTFEELLLYFIFLITLCILTFGMVNPHMYYLNKVMSSLFVDTALPDDEKSSFRSIRSITDFWKFVEGPLLEGLYWDSWYNNQKLYNLKNSSRIYYENVLLGVPRVRQLRVRNNTCKVYSAFKSLISDCYGKYTTENEEVSDFGLKNDTEWKYSTSPANAPWHWGFVGVYRDGGYMFTLSKSKSHTQTKLIDLRLNSWITRGTRVVFIDFSLYNANINLFCIVRLVAEFPATGGLLTSWQFYSVKLLRYVTHYDYFIASCEIIFCIFLFVFITQELRKLNELKSAYFKSIWNWLEMLLLALCFLAVSFYAYCHMQNFLLLERLLKNTENYPNFYFLAYWHIYYNNIIAITIFFAWIKIFKFISFNETMSQLSSTLSRCMKDIVGFAIMFFIIFSAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANWILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYAIGRRPDFELGKIIKKSYFNVLEKLGLKKAQDNEDKKMKTTGDLAQQARKEGFNESEIQQAEHMKTWKERLEKKYYSTEIQDDYQPVTQQEFRELFLYAVELEKELHYISLKLNQVMRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MTB8</accession>
    <name>A0A8C2MTB8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox protein Hox-B7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Hoxb7</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003499599.1">
        <property type="nucleotide sequence ID" value="XM_003499551.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280027.1">
        <property type="nucleotide sequence ID" value="XM_027424226.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MTB8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027564.1">
        <property type="protein sequence ID" value="ENSCGRP00001023318.1"/>
        <property type="gene ID" value="ENSCGRG00001021590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774273"/>
    <dbReference type="KEGG" id="cge:100774273"/>
    <dbReference type="CTD" id="3217"/>
    <dbReference type="GeneTree" id="ENSGT00940000161230"/>
    <dbReference type="OMA" id="QNCNKTD"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030099">
        <property type="term" value="P:myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090190">
        <property type="term" value="P:positive regulation of branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000017">
        <property type="entry name" value="Homeobox protein antennapedia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF11">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027280027.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24036" checksum="AA3779443FDD95B4" modified="2022-01-19" version="1">MSSLYYANALFSKYPAASSVFAPGAFPEQTSCAFASNPQRPGYGAGPGAPFSASVQTLYPGGGGMAGQSAPGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDPAKAAGAKEQRDSDLAAESNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTSGQGVTGQDKAEAEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MX65</accession>
    <name>A0A8C2MX65_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17 20">Zinc finger protein 189</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Znf189</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003504066.1">
        <property type="nucleotide sequence ID" value="XM_003504018.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258903.1">
        <property type="nucleotide sequence ID" value="XM_027403102.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MX65"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029445.1">
        <property type="protein sequence ID" value="ENSCGRP00001025199.1"/>
        <property type="gene ID" value="ENSCGRG00001022874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755468"/>
    <dbReference type="KEGG" id="cge:100755468"/>
    <dbReference type="CTD" id="7743"/>
    <dbReference type="GeneTree" id="ENSGT00940000161823"/>
    <dbReference type="OMA" id="CHISLIQ"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009891">
        <property type="term" value="P:positive regulation of biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001394">
        <property type="entry name" value="Zinc finger protein 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000631">
        <property type="entry name" value="zinc finger protein 189 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001697">
        <property type="entry name" value="zinc finger protein 623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000953">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000330">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027258903.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="70752" checksum="9BF44229AB2EA9EB" modified="2022-01-19" version="1">MASPSPLLEPKEEWDYLDPTRRSLYKDVMMDSYGNMVSLDVLSKNKDEEPTVKEEIEEDIEPPGVIVTRIKSEIDQDPIATETFELVGRLDKQRGIFLWEIPRESLTQEQKMFRGHANVRKRPNSEEKCHKCEECGKGFARKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHIREKTSLYNETKESFDPNCSLVVQQEVCPKEKSYKCDECGKTFSVSAHLVQHQRTHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCEECGKAFSRNSGLIQHQRIHTGEKPYRCEKCDKSFSQQRSLVNHQKIHTEVKKQEIYECDACGEAFNCQISLIQHQKLHIMWMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MXE6</accession>
    <name>A0A8C2MXE6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Neutral amino acid transporter 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Solute carrier family 38 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26 27" type="primary">Slc38a9</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26 27">17A/GY</strain>
            <tissue evidence="26 27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-asparagine(out) = L-asparagine(in)</text>
            <dbReference type="Rhea" id="RHEA:73423"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamine(out) = L-glutamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73419"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-leucine(in) = L-leucine(out)</text>
            <dbReference type="Rhea" id="RHEA:73011"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosine(in) = L-tyrosine(out)</text>
            <dbReference type="Rhea" id="RHEA:68572"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003503482.1">
        <property type="nucleotide sequence ID" value="XM_003503434.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007642236.1">
        <property type="nucleotide sequence ID" value="XM_007644046.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257266.1">
        <property type="nucleotide sequence ID" value="XM_027401465.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257267.1">
        <property type="nucleotide sequence ID" value="XM_027401466.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MXE6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029550.1">
        <property type="protein sequence ID" value="ENSCGRP00001025304.1"/>
        <property type="gene ID" value="ENSCGRG00001022941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767955"/>
    <dbReference type="KEGG" id="cge:100767955"/>
    <dbReference type="CTD" id="153129"/>
    <dbReference type="GeneTree" id="ENSGT00390000005646"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990877">
        <property type="term" value="C:FNIP-folliculin RagC/D GAP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015182">
        <property type="term" value="F:L-asparagine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032935">
        <property type="term" value="F:sterol sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF244">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="22">
        <location>
            <begin position="118"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="22">
        <location>
            <begin position="294"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027257266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027257267.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="63509" checksum="9A735A227A57FA90" modified="2022-01-19" version="1">MASVDSDSRHLIPEVDLEVNPGPMNIQFDSSDLRSKRPFYIEPTNIVNVNGVIQRVSDHASALNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLQSYTEGYGKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIVLMGLLTLYCCYRVVKSRSMICTSDTTTWEYPDVCKHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNVIHHINDTDTILRTNNSNPVICPSAGSGGHPDNSSVIFYNDTQVQQFEKWWNKSKTVPFYLIGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFLVTWKAFRLGFHLEFHWFVQTEFFVPEIRFEFPQLTGVLTLAFFIHNCIITLLKNNKNQENNVRDLCIAYMLVTLTYLYIGFLVFASFPSPPLSKDCIEQNFLDNFPSSDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNVIIVGAGVTMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISLHQEERLTWPKLVFHVFIIILGLANLIAQFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MXT5</accession>
    <name>A0A8C2MXT5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">LOC100766959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in an early step of the mitochondrial complex IV assembly process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003498334.3">
        <property type="nucleotide sequence ID" value="XM_003498286.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242637.1">
        <property type="nucleotide sequence ID" value="XM_027386836.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MXT5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026230.1">
        <property type="protein sequence ID" value="ENSCGRP00001021986.1"/>
        <property type="gene ID" value="ENSCGRG00001020671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766959"/>
    <dbReference type="KEGG" id="cge:100766959"/>
    <dbReference type="OMA" id="KKTPKEC"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002521">
        <property type="term" value="P:leukocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027242637.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8440" checksum="3B71625B9398B01F" modified="2022-01-19" version="1">MPRYYEDKVEGGACAGVKEDLGACLLQSACVLQEGKSPRQCLKEGYCRALQYSFFECKRSMLDTRSRFRGRKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MZS4</accession>
    <name>A0A8C2MZS4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox protein HB9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Mnx1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027284433.1">
        <property type="nucleotide sequence ID" value="XM_027428632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MZS4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030364.1">
        <property type="protein sequence ID" value="ENSCGRP00001026118.1"/>
        <property type="gene ID" value="ENSCGRG00001023539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751599"/>
    <dbReference type="KEGG" id="cge:100751599"/>
    <dbReference type="CTD" id="3110"/>
    <dbReference type="GeneTree" id="ENSGT00940000160059"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031018">
        <property type="term" value="P:endocrine pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021520">
        <property type="term" value="P:spinal cord motor neuron cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000243">
        <property type="entry name" value="Motor neuron and pancreas homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042768">
        <property type="entry name" value="MNX1/Ceh-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335:SF3">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="241"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="302"/>
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            <begin position="343"/>
            <end position="354"/>
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        <location>
            <begin position="355"/>
            <end position="365"/>
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        <location>
            <begin position="390"/>
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        <source>
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    <sequence length="403" mass="41115" checksum="40F5F3A8BF31AFE0" modified="2022-01-19" version="1">MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLAATASGPGRGGNGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYGYSAAAAAAALAGQHPALSYSYPQVQGAHPSHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFSSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGSGKGCAEEKAEEELLGPPVSGDKASGRRLRDLRDSDPDEEDEDEDDHFPYSNGAGTHAASSDCSSEDDSPPPRPGGPGHQPLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N8Q8</accession>
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        <recommendedName>
            <fullName evidence="10">Multiple epidermal growth factor-like domains protein 9</fullName>
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        <name evidence="17 20" type="primary">Megf9</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
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    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">17A/GY</strain>
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    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="nucleotide sequence ID" value="XM_027400254.2"/>
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        <property type="protein sequence ID" value="ENSCGRP00001026593.1"/>
        <property type="gene ID" value="ENSCGRG00001023864.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:animal organ morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Laminin subunit gamma 2"/>
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        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EGF_Lam"/>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="5"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679148" description="Multiple epidermal growth factor-like domains protein 9" evidence="15">
        <location>
            <begin position="35"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="200"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
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        </location>
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        <location>
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            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="396"/>
            <end position="447"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
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            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
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            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
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            <end position="279"/>
        </location>
    </feature>
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            <end position="325"/>
        </location>
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        </location>
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    </feature>
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            <end position="430"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070404"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00078818"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027256055.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="62890" checksum="CED9079E544C2D0E" modified="2022-01-19" version="1">MNGGADRAMRSLPSLGGLALLCCAAAAAASAASAGNVTGGGGTEGQVVASPTPGLRDQASHPFPKAAAPTTQAPRSGPPRTTVRRAGTATQSAGSPETTPLRITARPPATTFPGLDPSPATPSEEGRTPATEPPPSRPAPSTLESTAGQAPTTPIVTTAQAPSTPGTPTTESRDSSISNSIPPTAPATEAPAPSPPEYICNCSEIGSLNVKLCNQTSGQCECHPGYQGLHCETCKEGFYLNHTVGLCLPCNCSPHGSLSILCNSSGNCQCRVGITGSMCDQCQDGYYGFNMTGCLPCQCNNRSSSCDVLTGACLNCQENSKGDHCEECKEGFYQSPDATKECRRCPCSAVTSTGNCTIESGELEPTCVQCKDGYTGQNCNKCENGYYNSDSICTRCECHGHVDPTTTPKICKPESGECINCLHNTTGFWCENCLEGYIRDLQRNCIKQEVIVPTPEGSTILVSNASLTTSVSTPVINSTFAPTTLQTIFSVSSSENSTSALADVSWTQFNIIILTVIIIVVVLLMGFVGAVYMYREYQNRKLNAPFWTIELKEDNISFSSYHDSIPNADVSGLLEDDGNEVAPNGQLTLTTPIHNYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QER1</accession>
    <name>A0A8C2QER1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Med23</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003513138.1">
        <property type="nucleotide sequence ID" value="XM_003513090.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258711.1">
        <property type="nucleotide sequence ID" value="XM_027402910.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001009749.1">
        <property type="protein sequence ID" value="ENSCGRP00001006223.1"/>
        <property type="gene ID" value="ENSCGRG00001008295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100775007"/>
    <dbReference type="KEGG" id="cge:100775007"/>
    <dbReference type="CTD" id="9439"/>
    <dbReference type="GeneTree" id="ENSGT00390000010380"/>
    <dbReference type="OMA" id="QKHQKQR"/>
    <dbReference type="OrthoDB" id="9982951at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000409">
        <property type="term" value="P:positive regulation of T cell extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1352"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1355"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027258711.1"/>
        </source>
    </evidence>
    <sequence length="1376" mass="157240" checksum="32CB88D6B3EB9DDD" modified="2022-01-19" version="1">MVTMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWNGLSQDSHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWSLTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDDSNLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSNAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNFMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAVPPQALNSGSPAPQSTQVPASLPVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QES1</accession>
    <name>A0A8C2QES1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9 12">Histone H3.3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">LOC100759664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027270992.1">
        <property type="nucleotide sequence ID" value="XM_027415191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QES1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010877.1">
        <property type="protein sequence ID" value="ENSCGRP00001006897.1"/>
        <property type="gene ID" value="ENSCGRG00001009381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759664"/>
    <dbReference type="KEGG" id="cge:100759664"/>
    <dbReference type="OrthoDB" id="9609993at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="43"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027270992.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15052" checksum="563336D6E5851AD4" modified="2022-01-19" version="1">MACIKQTARKSRGKAPWKQLATKAARKSAPPTGGVKKPPRYRPGTVALGEIRCYQKSTELLIRKLPFQCLVQEIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QLB3</accession>
    <name>A0A8C2QLB3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Dync1li1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027271106.1">
        <property type="nucleotide sequence ID" value="XM_027415305.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QLB3"/>
    <dbReference type="SMR" id="A0A8C2QLB3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024359.1">
        <property type="protein sequence ID" value="ENSCGRP00001020115.1"/>
        <property type="gene ID" value="ENSCGRG00001019361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768032"/>
    <dbReference type="KEGG" id="cge:100768032"/>
    <dbReference type="CTD" id="51143"/>
    <dbReference type="GeneTree" id="ENSGT00390000008295"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030666">
        <property type="term" value="C:endocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061502">
        <property type="term" value="P:early endosome to recycling endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090267">
        <property type="term" value="P:positive regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF2">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="387"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="457"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027271106.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="56595" checksum="11AF81A5823626AB" modified="2022-01-19" version="1">MAAVGRVGSFGSSPPGLASTYASGPLANELASGSGGPAPGDDEDGQNLWSCILSEVSTRSRSKLPTGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDALSLKDTLVILVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKEMEHKLIRDFQEYVEPGEDFPASPQRRATATQEDRDDSVVLPLGADTLTHNLGLPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKTPAVVVEKDAVFIPAGWDNDKKIGILHENFQTLKIEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASPRVPGGSPRTPNRSVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNSLLSKKTGSPGGPGVGGSPGGGAAGGSSGLPPSAKKSGQKPVLSDVHAELDRITRKPASVSPTTPTSPTEGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QM13</accession>
    <name>A0A8C2QM13_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8 11">Musculin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">LOC113833761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027254502.2">
        <property type="nucleotide sequence ID" value="XM_027398701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QM13"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025791.1">
        <property type="protein sequence ID" value="ENSCGRP00001021547.1"/>
        <property type="gene ID" value="ENSCGRG00001020363.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113833761"/>
    <dbReference type="KEGG" id="cge:113833761"/>
    <dbReference type="OrthoDB" id="6233288at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014707">
        <property type="term" value="P:branchiomeric skeletal muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060539">
        <property type="term" value="P:diaphragm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19703">
        <property type="entry name" value="bHLH_TS_musculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF62">
        <property type="entry name" value="MUSCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027254502.2"/>
        </source>
    </evidence>
    <sequence length="211" mass="22064" checksum="72C7B610AFCFCCCA" modified="2022-01-19" version="1">MSTGSVSDPEDMETRGLQRVHPAPASKRPPLHSTERGYGSPSDNSSAEEEDPDGEEGSCSLGAVGIPGGCKRKRPRVAGAGGAGGGGAGGGAGGGGKKPLPPKGSAAECKQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYENSYVHPVNLTWPFVVSGRPDSDTKDVSAASRLCGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F134</accession>
    <name>A0A9J7F134_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100768575</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003513189.1">
        <property type="nucleotide sequence ID" value="XM_003513141.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247664.1">
        <property type="nucleotide sequence ID" value="XM_027391863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F134"/>
    <dbReference type="GeneID" id="100768575"/>
    <dbReference type="KEGG" id="cge:100768575"/>
    <dbReference type="OrthoDB" id="9528504at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15912">
        <property type="entry name" value="7tmA_OR6C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000013">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF50">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="38"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027247664.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35748" checksum="5B356831E695D959" modified="2023-06-28" version="1">MKNNTITTFILLGLTDDPQLQIPIFVLLFFAYMLSITGNLAIISLTTLDSHLKTPMYFFLQNFSILEIAFTSACIPRYLYNIATGDRSITYNICVIQVFFTDVFGVTEFFLLAVMSYDRYVAICKPLHYVTIMSSKVCHKLVLCCWIAALLIILPPLTLFLNLRFCDSNVIDCFFCDASPILKISCSDTWLIEQLVIVCAVLTFILTLVCVALSYVQVIKTILRFPSAQQRKKAFSTCSSHMIVVSITYGSCIFIYIKPSAKESVAINKGVAVLMTSIAPMLNPFIYTLRNKQVRQAFSDSFKKFAMISVKKGKDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F197</accession>
    <name>A0A9J7F197_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100763252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003512339.1">
        <property type="nucleotide sequence ID" value="XM_003512291.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245069.1">
        <property type="nucleotide sequence ID" value="XM_027389268.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F197"/>
    <dbReference type="GeneID" id="100763252"/>
    <dbReference type="KEGG" id="cge:100763252"/>
    <dbReference type="OMA" id="IAEEWSQ"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027245069.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="35109" checksum="52C2406936A8BA7E" modified="2023-06-28" version="1">MDKKLDIFRRELVDVHGIPLFWSIAEQWSQVESFEARPDDLLISTYPKSGTTWISEILDLIYNNGDAEKCKRDAIYKRVPFMELIIPGLSNGVELLKNMHSPRLVKTHLPVQLLPSSFWKNDCKMVYVARNAKDVAVSYYYFYQMAKIHPEPGTWEEFLDKFMAGQVGFGSWYDHVKGWWEKRNDYRILYLFYEDMKEDPKYEIQKLLKFLEKDMPEEIVNKILYHSSFNVMKENPNANYTTMKKEEMDHAVSPFMRKGISGDWKNQFTVAQYEKFEDDYVKKMKESTLKFRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F1L5</accession>
    <name>A0A9J7F1L5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 8 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">Glt8d1</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13 14">17A/GY</strain>
            <tissue evidence="12 13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007630096.1">
        <property type="nucleotide sequence ID" value="XM_007631906.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016828281.1">
        <property type="nucleotide sequence ID" value="XM_016972792.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245358.1">
        <property type="nucleotide sequence ID" value="XM_027389557.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245359.1">
        <property type="nucleotide sequence ID" value="XM_027389558.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245360.1">
        <property type="nucleotide sequence ID" value="XM_027389559.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279419.1">
        <property type="nucleotide sequence ID" value="XM_027423618.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F1L5"/>
    <dbReference type="GeneID" id="100762757"/>
    <dbReference type="KEGG" id="cge:100762757"/>
    <dbReference type="CTD" id="55830"/>
    <dbReference type="OMA" id="YKQHSNI"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000069">
        <property type="entry name" value="Glycosyltransferase 8 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027245358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027245359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027245360.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42117" checksum="6C1AB20DBC0E1133" modified="2023-06-28" version="1">MSFRKVSIIIWVLAIVLFLLVLHHNFLSLSSLLRNEVSDSGILGLQPIDFVADIHQHPVNGRQEEIPVVIAASEDRLGGTIAAINSIHHNTRSNVIFYIVTLNSTEDHLRSWLNSVSLKSIRYKIVNFDTKLLEGKVKEDPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSTSTKVIIRGAGNQYNYIGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRAASYADVWEKWYIPDPTGKFSLIRRHMDTSNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F6L0</accession>
    <name>A0A9J7F6L0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trichohyalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Tchh</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027249195.1">
        <property type="nucleotide sequence ID" value="XM_027393394.2"/>
    </dbReference>
    <dbReference type="GeneID" id="118237655"/>
    <dbReference type="KEGG" id="cge:118237655"/>
    <dbReference type="CTD" id="7062"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="S-100"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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        <property type="entry name" value="S-100_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033200">
        <property type="entry name" value="TCHH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34855">
        <property type="entry name" value="TRICHOHYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34855:SF1">
        <property type="entry name" value="TRICHOHYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="885"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1383"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1439"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="831"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="861"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1154"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1400"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027249195.1"/>
        </source>
    </evidence>
    <sequence length="1476" mass="190616" checksum="74D0EEAA4D7F566C" modified="2023-06-28" version="1">MSPLLRSVIDIAEIFDHYASHSCDGASLSKKDLKNLLERELGTVLQRPQDPETVDLTLALLDRDSNGRVDFNEFLLFLFKIAQACYYALDQTSGLDEKRNVSQDRRQEDQRRFEPQDVQRDEERGHQSRQKRHEQEERTDEQRKRQERLEQEEQRRELQELEERLAEKEPLSWSQGPDAEEFSEEENLRERQELKSKDQTEERRLQKRRREEVSDPQLRRDAQLRRDPQLRREQELVAEEEEQTRLQEPDDSFTRRWQQQLESEAEARQNKVYSRPRRQEAEERQLREQGQRRDLRRQRLAEEERLEQEQRFREPQRQRSQRRDGEEQSFREEELQRAELQDSLLEERQRRRRDASRSRQLQEESQRCHTRYAEPSQRQQSGEELREERLLQEEAQRRQQRDRKYLREEERLQQQEEERLQQEEERLQQQEERLQLEEERLQRREEQLQREKRHLQRERQYQEEDLQQEEERLQQEEELLQQEEERLQQERRRLQRGRQYQEEDLQRLRDVDQRRDLKWQWQPEKENEARRHRLFSKRRQDEERTRQLEDSLEQERRLRQDRRPLREEAGEKRELEQETRRRLQRDRQLLEEEQLQREHQREARRRDENIQEEEQLLRDSRRRPQERDAKFLEEEKQLRKRREEHRRRQEQERQFQEEEELRHQEREKELRQERGRNSCEEQELRQQLEADQRRQELREEEQRRQQRDRRVRQEEELRQELREEEQRRQQRDRRVRQEEELRQELREEEQRRQQRDRRVRQEEELRQELREEEQRRQQRDRRVRQEEELRQELREEEQRRQQRDRRVRQEEELRQELREEEQRRQQRDRRVRQEEELRQELREEEQRRQQRDRRFRQEEELRQELREEEQRRQQRDRRFRQEEELRQELREEEQRRQQRDRRFRQEEELRQELREEEQLRHQERDRKSRGERELRQELEEEQFQGRKFLREQELRRDRKFREAERRQELEEEQLRHQKCDRKFREAERRQELEEEQLRHQERDRKFREAERRQELEEEQLRHQKCDRKFREAERRQELEEEQLRHQERDRKLREAERRQELEEEQLRHQERDRKLREAERRQELEEEQLRHQERDRKLREAERRQELEEEQLRDRKLRAEEQLRGEREEERRRGQECDRKFRREQEFSQELEEEQPRDRKFRREQELRRDRKFHEEEERRQQLEEEQLRHQERDRKFREAQRRQERDRKFHEEERLQELEEEQLRDRKLRVEEQLRREQEEERRRGQECDRKFRREKEFRQELEEEQPRDRKFRREQELRRDRKFHEEERLQELEEEQLRRQERGRKFLEEEERRQERDRRFRGEPELRKEREGQQRRLQELEEEQLRFEEQKRRHQELEQQLRQERDRKFREEKQLRQEREELQLRRQKRDGQYPAEEQFARDKIRRQEQEQRQEEEQKRRQELERKFQEEQIRRQAEQRRRQILESGTRQFANVPVRSSPLYEYIQEQRSQYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F942</accession>
    <name>A0A9J7F942_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase-activating protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100757375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027250818.1">
        <property type="nucleotide sequence ID" value="XM_027395017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F942"/>
    <dbReference type="GeneID" id="100757375"/>
    <dbReference type="KEGG" id="cge:100757375"/>
    <dbReference type="OrthoDB" id="9558881at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13319">
        <property type="entry name" value="PH_RARhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04402">
        <property type="entry name" value="RhoGAP_ARHGAP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047886">
        <property type="entry name" value="ARHGAP20-like_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047887">
        <property type="entry name" value="ARHGAP20_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF37">
        <property type="entry name" value="1700006A11RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22286">
        <property type="entry name" value="RHG20_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="305"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027250818.1"/>
        </source>
    </evidence>
    <sequence length="788" mass="88724" checksum="FDE5A7D2E7D1DAB1" modified="2023-06-28" version="1">METLDENATGVIHRTLLCQGPVELRRGWRRKQQHLSLFSDVLVVSNNLCKRKFNIKYVIPLSFLWMGDYVDILGTDSSSADKSILLFWPMGNFVATFRSTEQKDRWYSFLQRSINEATKGYRKHFKLPIFTEDIPSCASPLYVTTTDLETVNDVIQKLLPLIGMPSAQDYQLWFCHDREKAPGLLQEHEHLYDIIMRNIKNPFSQWASRNHTAFPALPGLYVEQPDIQGRFILKPREPARIQKQNSCTNETTLYNDLISSLDTEEPRIKKQWPFISWLFQRSSVPYQNQMCTAPPVAKTGKLFGHDLTAICEDGNLPTAILDILSFISEKGPITEGIFRTSGDIRAFRALKERLDSGIEVNLNNESVPVVASILKEFLQNIEGSVLTSRLYDEWLAVLDQVCEEEKAAAVQRLLEQLPQPNVILLKQLFGILYKIERNSEVNHMTSSNLAVCIALSILCLPSSCNSGFPDVSKKICLVSFLIENYPKIFGEDSPFHDESSFVCSDGEKSYNSLNTVTDNVEMEVKEHEDNTCPSGSTCPTGNDAVSRSPSAPLHNEGIIDSEEDVKTSFINPTITQDPDTSQDNMCLTPPEPNEEHPIENTHTPPAANEANLSNSDTPPAAKSKIVFGNTHTPPAPNKENLEISTPLAPIALTTPVKAFSQLQIFSVIIVILCCILHILYCYNKSHSIIDCLDFFMIPHSLWRMLTILFTKHLQLPYDFIKELKTTNCGCVMAMKKPQAYSKFISGALYNLLLEAPRKPDPLLKSALGSPPQTATWRKQKGPHTRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FF94</accession>
    <name>A0A9J7FF94_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">A-kinase anchor protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Akap7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027258701.1">
        <property type="nucleotide sequence ID" value="XM_027402900.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316322.1">
        <property type="nucleotide sequence ID" value="XM_035460431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FF94"/>
    <dbReference type="GeneID" id="100757731"/>
    <dbReference type="KEGG" id="cge:100757731"/>
    <dbReference type="CTD" id="9465"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1140.10:FF:000004">
        <property type="entry name" value="A-kinase anchoring protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019511">
        <property type="entry name" value="AKAP7_RI-RII-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF6">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7 ISOFORM GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10470">
        <property type="entry name" value="AKAP7_RIRII_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039896422" description="A-kinase anchor protein 18" evidence="8">
        <location>
            <begin position="17"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="9">
        <location>
            <begin position="121"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="A-kinase anchor protein 7 RI-RII subunit-binding" evidence="10">
        <location>
            <begin position="384"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038702"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027258701.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49334" checksum="46184C0DDAC3C320" modified="2023-06-28" version="1">MLRLAGLRASAGLAAAASAPATPRPPGLRLLLRPATMERPAAGEINSNQCESVLREETVSGELEISTENSLTDMPFATVDIQDDCGITDVPQMNSKRSKEKEGIKNDHIKKRKKATKNYQPNYFLSVPITNKKITAGIKVLQNTILQQDKRLAKAMVGDGSLHITLLVMQLLNEDEVNIGTDALLELKPFIEEILQGKHLTLPFQGIDTFQSQVGFVKLADGDHINTLTEIAETAKRTFQEKGILAGESRSFKPHLTFMKLSKAPMLRKKWCARQRRAVDQQRQTSKTAGEIYSHLLLTRGDAVIEGVKKIEPELYEQFINHRFGEEILYQIDLCSMLKKKQSNGYYHCEASIVIGELESPSSAVLQRYSKERPNGPSGEKDRGEPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSSKAEEANQNGKGSDNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FJG7</accession>
    <name>A0A9J7FJG7_CRIGR</name>
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        <submittedName>
            <fullName evidence="5">Protein FAM219A isoform X2</fullName>
        </submittedName>
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    <gene>
        <name evidence="5" type="primary">Fam219a</name>
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    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM219 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027259124.1">
        <property type="nucleotide sequence ID" value="XM_027403323.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FJG7"/>
    <dbReference type="GeneID" id="100770378"/>
    <dbReference type="KEGG" id="cge:100770378"/>
    <dbReference type="CTD" id="203259"/>
    <dbReference type="OrthoDB" id="6119141at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029339">
        <property type="entry name" value="FAM219"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281:SF0">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15260">
        <property type="entry name" value="FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027259124.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32369" checksum="ED28A130D967154A" modified="2023-06-28" version="1">MMEEIDRFQVPTAHSEMQPLTPMRASAVTILWYFGIPVPLMITTPVGFFGSEERLWIPCSVYSCAPDRKSKCTTFSMGQLSRKHRAESCCLQTLAYLHKSNPTELLGGAGSLRGVRGQGLIMRARRHQDPAAASISDGDCDAREGESVAMNYKPSPLQVKLEKQRELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDSDDDFDMSRYSSSGYSSAEQINQDLNIQLLKDGYRLDEIPDDEDLDLIPPKSVNPTCMCCQATSSTACHIQ</sequence>
</entry>
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    <accession>A0A9J7FM82</accession>
    <name>A0A9J7FM82_CRIGR</name>
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        <submittedName>
            <fullName evidence="5 6 7">Protein Lines homolog 1</fullName>
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        <name evidence="5 6 7" type="primary">Lins1</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5 6 7">17A/GY</strain>
            <tissue evidence="5 6 7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027263904.1">
        <property type="nucleotide sequence ID" value="XM_027408103.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263905.1">
        <property type="nucleotide sequence ID" value="XM_027408104.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263906.1">
        <property type="nucleotide sequence ID" value="XM_027408105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FM82"/>
    <dbReference type="GeneID" id="100767653"/>
    <dbReference type="KEGG" id="cge:100767653"/>
    <dbReference type="CTD" id="55180"/>
    <dbReference type="OrthoDB" id="8251209at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029415">
        <property type="entry name" value="Lines_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032794">
        <property type="entry name" value="LINES_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024875">
        <property type="entry name" value="Protein_Lines"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16057:SF1">
        <property type="entry name" value="PROTEIN LINES HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16057">
        <property type="entry name" value="WINS1, 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14695">
        <property type="entry name" value="LINES_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14694">
        <property type="entry name" value="LINES_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Lines N-terminal" evidence="2">
        <location>
            <begin position="180"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Protein Lines C-terminal" evidence="3">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027263904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027263905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027263906.1"/>
        </source>
    </evidence>
    <sequence length="754" mass="84564" checksum="D10D68103E891D78" modified="2023-06-28" version="1">MEGVEEILDQLYKKVLLGGTLEDDVHGYIFYLNPNLSEQADCTTPSLTRSNVSGTLGGVPGAKSPFEMSRAREVKLLQLTVMDVMLSRVLSAETEALAKEGYRKLTEGLLQSAEVDSKLIWMLQNSDKLMSHLAAKCLSSLLYFQLRAKMALSNPWITFCQKHLSESPESREAVHCLWILTVVIKEIFKDTHCQQAEMLKQLLAPFDITFEVFYNSLFSQHFGNFQNPSNVVNSLVCFLELLELLTASRIHLKLHFKSQRMLFLKPCALDILAWPIPAFVKRKLVIVIKKCLLGKMGEDLCRGSVPALMSPDHFLDGDVLALADALLHAVRLGLWKDLSVSGKPSRFGGDEVQPGCQPRIGPDYVTLRAASLITVKSLEIKFQNCTSAAEMRADLQKFMSELLTFLKSHLRRPLRLYNPCEWLFRVFIEQDDDMVEAAKASLSIYLQLTRGQDDTSGRLTQENEAWIHYTHRNGCNPHCIFLFLLKNIVFDSTVLLDFLISSETCFLEYFVKYLKLLQRDWGHFLAICKFFDAAKLQCGVHTHGAVTPSLVQDSRASHTIQRALASPVGHTVPHALASPVGHRNACPQVSWASNASSEPQSQVVMARQAHTVPAHGPPSQTPLSLVDYESSEDSDEEATNQHLANYRQTSSHQEMSRETQGLPRTSQNRKERSRSREHQQRLLLPLQSNPPNCATGEVAPNGAVQEVGLFLRTVKCLQELQDAIERLQEKNLFPYNPAALLKLLKVVGAKCGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FN96</accession>
    <name>A0A9J7FN96_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MHC class II regulatory factor RFX1 isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Rfx1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027261996.1">
        <property type="nucleotide sequence ID" value="XM_027406195.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FN96"/>
    <dbReference type="GeneID" id="100767562"/>
    <dbReference type="KEGG" id="cge:100767562"/>
    <dbReference type="CTD" id="5989"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007668">
        <property type="entry name" value="RFX1_trans_act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF23">
        <property type="entry name" value="MHC CLASS II REGULATORY FACTOR RFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04589">
        <property type="entry name" value="RFX1_trans_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="536"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1011"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027261996.1"/>
        </source>
    </evidence>
    <sequence length="1076" mass="115851" checksum="A8977C878F7E6F14" modified="2023-06-28" version="1">MATQSYVTELQAAPQASQPPQAPPQALPQPPPPTAPQPPAAATPQPQYVTELQSPQPQPQPPGSQKQYVAELPAAPAPSQPATPAPSPVAQQYIVVTVSEGAMRASETVSETSPSSTASQTGVPTQVVQQVQGSQQRLLVQASVQAKPGHVSPLQLTNIQVPQQALPTQHLVVQSTAQGTKGGQVSLTVHSAQQVHSAPERSPVQANNSTSKTAGAPAGTVQQLQVHSVQQSVPVSQERSVVQATPQTKAGPVQQLTVQGLQPVHVTQESSGSKFPARKAEQREPRPTPPPEPPPRLPGPGPACCGQASQLGSPEQPPPHYEPGVEQWVELVGVLPPHLLLPQQRVVFEPLPGLSARASPDLRVRIHRMPQVLVFGTALKVQQLQQVPVSHVYSSQVQYVEGGDASYTASAIRSSTYPYPETPIYTQPAGTSYYEASGTAAQVSTPATSQTVASSGSVPMYVSGSPIVASSSSSEAGASNSSVGAGGSGGGGSSGSSSGGGGGSGSGAGTYVIQGGYMLGNASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGVANGVAVGQQSTGLSDISAQVQQYQQFLDASRSLPDFVELDLQGKVLPEGVGPGDVKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPNEAAPLAVHDEGEKRLPRASLVLLSKFQPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSSGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLTTSLNPLDPDKDEEEEEEEESEDDLPQDISLAAGSESPALGPEALEPPAKLARSDTRGLFVQALPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FW85</accession>
    <name>A0A9J7FW85_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Lamp3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer. Interacts with FURIN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Lysosome membrane</location>
            <topology evidence="3 19">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027268893.1">
        <property type="nucleotide sequence ID" value="XM_027413092.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FW85"/>
    <dbReference type="GeneID" id="100757631"/>
    <dbReference type="KEGG" id="cge:100757631"/>
    <dbReference type="CTD" id="27074"/>
    <dbReference type="OrthoDB" id="9428839at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097233">
        <property type="term" value="C:alveolar lamellar body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.110:FF:000006">
        <property type="entry name" value="Lysosome-associated membrane glycoprotein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF30">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="14 19" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039905800" description="Lysosome-associated membrane glycoprotein 3" evidence="21">
        <location>
            <begin position="22"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="22">
        <location>
            <begin position="219"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027268893.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="44633" checksum="5AA1318D2E866E12" modified="2023-06-28" version="1">MPGQLSAAAVLFLSLAVILHGRQMREKEFPKSRDYLQYTSTVTGQTTAKPLLQLTNQTHHETLAARPRDGDIQMSAEDNTSENAAHTTTKTIIPVTTKSLLPSSPANYTIVTPNSSHVTTLSTEGTIGPSSVAHLPIHTTGASLSTVDHITSRTTQLGGQTTLHQTFFTASHKSTTNQKSTLPTNVPGASVPTHNVSFATSPAPIVPGPTLATQSSPAKTGTYEVLNGSRLCIKAEMGLELIVQEKDLDFATQRHFNIDPSLTHASGKCGSQKSNLFLDFQGGSVNITFIKEENSYYVSKVGAYLTVSNTERTYQGMTHRMVMFETVVGHSFKCVSEQRIQLSAQLQMKTTNIRLQAFDFEGDCFGNVDECLSDYTVVLPVVGAIVVVLCIVGLAVYKIRQRHQSLGYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FZW4</accession>
    <name>A0A9J7FZW4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Disintegrin and metalloproteinase domain-containing protein 20-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC107977719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272559.1">
        <property type="nucleotide sequence ID" value="XM_027416758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FZW4"/>
    <dbReference type="GeneID" id="107977719"/>
    <dbReference type="KEGG" id="cge:107977719"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990913">
        <property type="term" value="C:sperm head plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF140">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="238"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="10">
        <location>
            <begin position="440"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027272559.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="87459" checksum="601D6745CA985C09" modified="2023-06-28" version="1">MGFLKIQSFKAVATAERFSLVSSIVLSLNWGMRLVGKSVTLRAPLLLAALWVLLLVPSQCFQGRPTWRYVSSEVVTPRKVTYHGKGFQAPGRLSYSLRFRGQRHIIHMRRKTLIWPRHLLLTTQDDQGALQMDFPFFPVDCYYVGFLEEIPQSTVTLDTCSGGLNGVVMFDDLAYEIKPLSDSHRFEHVISQVVADSGAVGPMNKGKHTEHNLDPVFSGTNSSEAPRISSRDYASHPAAIKGHFQAGFSVYVKADRNQSRTCHYLFSLASLMDTYFNSIHVRYYVILLTVYTAESNYLKDLRMPGGLASQYYKNNFYNTYKPDSSNLVNEFEPLDEFYPVYHSVCGPDALNCVGQNNRYYVYVSVVVTHRVGWTLGLNKDDEEYCVCQRRSTCVMFQNPQLTDVFSNCSIAHLNHIFNTHSNLTCLFYDFHTYYNRSATYSVCGNAVINEGEQCDCGSNKACYVNPCCENNCTYSRDSICDKELCCTNCTYSPPGTLCRSVQNVCDLPEYCSGTAVTCPNDFYLQDGTPCSEEGYCYAGNCTDRNVHCKEIFGAGARAGNPMCYEINKEKFRFGHCRRAKESLVFTLCSDQDKMCGRLQCTNVTYLPHLQDHVSFHQSVISGFSCFGLDEHRGTGATDVGHVRYGTQCSKSNFCDRGSCNGSLTGLNYDCTPAKCNFRGVCNNLRHCHCHLGWEPPHCVGAGFGGSLDGGHLLPNMRTIRQSKEPVVYLRLVFGRIYLFIASLLFGVAFRVGFTKIIKYEVWKASALLHPQHHRPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G326</accession>
    <name>A0A9J7G326_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand calcium-binding domain-containing protein 11 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Efcab11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027274892.1">
        <property type="nucleotide sequence ID" value="XM_027419091.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G326"/>
    <dbReference type="GeneID" id="100769192"/>
    <dbReference type="KEGG" id="cge:100769192"/>
    <dbReference type="CTD" id="90141"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027274892.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20775" checksum="8E00EBD03AB1BB3E" modified="2023-06-28" version="1">MFPSVAGTRPRACEASASERRKWVEVFKACDEDNKGHLSREDFKVAIVMLFGYKPSKIEADSVMSSVNPNSSGISLEGFLDVVKRKKDAQLYRNEIRHLFTAFDVHYRGFLTLEDFKRAFSRVAPKLPERTVLEVFRQTNSRREAGFRGSSGHCETCRVEWPDLDVGGKAFQVEASRTALLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G3H6</accession>
    <name>A0A9J7G3H6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC103159225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC103159225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027271866.1">
        <property type="nucleotide sequence ID" value="XM_027416065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G3H6"/>
    <dbReference type="GeneID" id="103159225"/>
    <dbReference type="KEGG" id="cge:103159225"/>
    <dbReference type="OrthoDB" id="8887570at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053368">
        <property type="entry name" value="Viral_Envelope_Glycoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37874:SF1">
        <property type="entry name" value="RIKEN CDNA 1500011B03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37874">
        <property type="entry name" value="RIKEN CDNA 1500011B03 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027271866.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="12954" checksum="4850858AF66BCFBF" modified="2023-06-28" version="1">MESVLYNQAVSRVTTRAQWAGRGKGASRGGACGGSGVPTIGAGRAPEMLRARWLRLCTALCSLLLGQAQAQAPSPGVPPERSRPYAVLRGQNLVLMGTIFSILLVTVILMAFCVYKPIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G541</accession>
    <name>A0A9J7G541_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Palmitoyl thioesterase CPT1C</fullName>
            <ecNumber evidence="5">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Carnitine O-palmitoyltransferase 1, brain isoform</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Carnitine palmitoyltransferase 1C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Carnitine palmitoyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">Cpt1c</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027276512.1">
        <property type="nucleotide sequence ID" value="XM_027420711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G541"/>
    <dbReference type="GeneID" id="100767138"/>
    <dbReference type="KEGG" id="cge:100767138"/>
    <dbReference type="CTD" id="126129"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000008">
        <property type="entry name" value="carnitine O-palmitoyltransferase 1, brain isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000002">
        <property type="entry name" value="carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032476">
        <property type="entry name" value="CPT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF55">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 1, BRAIN ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16484">
        <property type="entry name" value="CPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 23" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Carnitine O-palmitoyltransferase N-terminal" evidence="27">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="26">
        <location>
            <begin position="175"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="22">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00077710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00083939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027276512.1"/>
        </source>
    </evidence>
    <sequence length="802" mass="90284" checksum="98CAD4A911A5E71A" modified="2023-06-28" version="1">MAEALQASSVLSSLSSDGAEVELTSPVWQEIYLSGLRSWKRHLWRVWNDFLTGMVPASPLSWLFLFSAIQLACFLQLDPSLGLMEKIKELLPDWGGQHYQLRGLLAAALFASCLWGALIFTLHVALRLLLSHHGWLLEPHGSMSSPTKTWLALVRIFSGRHPRLFSFQRALPRQPVPTAQESVRKYLESVRPVLGDDAFDHAAALASDFLKLQAPRLQLYLRLKSWCASNYVSDWWEEFVYLRSRGSLMVNSTYYMMQDFLYVTPTPLQSARAGNAVHALLLYRHLLNQQEIPPTLLMGMRPLCSAQFEKIFNTTRVPGVEKDYLRHLQDSRHVAVFHRGRFFRLQTHSSNGLLSPRALEQQFQEILDDPSPACPLEEHLAALTAAPRSMWAQVRESVKTHAATALEAVEGAAFFVSLDSEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPVSGHMWEFTLATECFQLGYAADGHCKGQPDPALPRPQRLQWDLPEQIHPSISLALRGAETLSGNIDCHVFPFSHFGKSFIKCCHVSSDSFIQLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRCCTREACQFVRAMEDKKTDQQCLALFRVAVDKHQALLKAAMSGQGIDRHLFALYVTSRFLHMPSPFLTQVQSQQWPLSTSQIPVQQMHLFDVHNYPDYVSAGGGFGPANDHGYGISYIFMGENMITFHISSKKSSTKTDSRRLGQHIEDALLDIASLFQAGQHLKCQFRRLGEKSGYRRGSLSSKTVDPKVPTTSTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G9N8</accession>
    <name>A0A9J7G9N8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luc7-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Luc7l3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds cAMP regulatory element DNA sequence. Plays a role in RNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May interact with SFRS1 and form homodimers. Interacts with JMJD6. Interacts with RBM25. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with RRP1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027280133.1">
        <property type="nucleotide sequence ID" value="XM_027424332.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G9N8"/>
    <dbReference type="GeneID" id="100767266"/>
    <dbReference type="KEGG" id="cge:100767266"/>
    <dbReference type="CTD" id="51747"/>
    <dbReference type="OrthoDB" id="10266921at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027280133.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="57826" checksum="BFAF0BBC014E7EAB" modified="2023-06-28" version="1">MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRSRDHKRSRSRDRRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSSSREKQSEDTNPESKESDTKNEVNGTSEDIKSEVQRKYAQMKTDLSRVRRHTKASSEGKDSVVLQNILRYIVLSQLFCSRLVPPLVCLFGNYCPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GBK0</accession>
    <name>A0A9J7GBK0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">F-box only protein 47 isoform X5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">Fbxo47</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4">17A/GY</strain>
            <tissue evidence="3 4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027279865.1">
        <property type="nucleotide sequence ID" value="XM_027424064.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279866.1">
        <property type="nucleotide sequence ID" value="XM_027424065.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GBK0"/>
    <dbReference type="GeneID" id="100757104"/>
    <dbReference type="KEGG" id="cge:100757104"/>
    <dbReference type="CTD" id="494188"/>
    <dbReference type="OrthoDB" id="9858120at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd22112">
        <property type="entry name" value="F-box_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056622">
        <property type="entry name" value="ARM_FBXO47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24467">
        <property type="entry name" value="ARM_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027279865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027279866.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51495" checksum="D280CB073B823648" modified="2023-06-28" version="1">MASKVNTSYTLIPNQKCKRTNHQSSYFCNTLDLDPQLLSTLGNFKVLPLEIFHIILRYLSVKDIGMLSMVSKTVSQHIINYISTSSGSRRLLIQNFHDLDLSGTKEESHLLEHYRALGLLFKRCTLLLPTKDRLKYIHKILSEVSCFKFSSCSAPLQCLGLPCYGMFLQTLTAGWDELECHRVYNFLCELTNLSRKMQTVVCNKPGSARKLELRIRLFCRNVLLDHWTQRSDSAFWLTRILKPWPMVNQARLLYIIFGPTSPQDGQVIWQEMVEGPTDESSLKGLANAIKLLYDTGTKEWTADDVISLVDELSVVPREWLLENNARLLILSGNNICFTFMASKAVNGRAIELARLIVFLALVCEKELYCMDWTVRMMQKVCKVFSAAAERKSFLQSVANAFACVTMEMLQPIMSGERDDDDRGFLNLFHLLHAQANFHKEVLYLTMNASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GEK4</accession>
    <name>A0A9J7GEK4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Retroviral-like aspartic protease 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Skin-specific retroviral-like aspartic protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">TPA-inducible aspartic proteinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Asprv1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007646785.2">
        <property type="nucleotide sequence ID" value="XM_007648595.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284336.2">
        <property type="nucleotide sequence ID" value="XM_027428535.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GEK4"/>
    <dbReference type="GeneID" id="100773346"/>
    <dbReference type="KEGG" id="cge:100773346"/>
    <dbReference type="CTD" id="151516"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000043">
        <property type="entry name" value="retroviral-like aspartic protease 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033539">
        <property type="entry name" value="Asprv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37006">
        <property type="entry name" value="RETROVIRAL-LIKE ASPARTIC PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37006:SF1">
        <property type="entry name" value="RETROVIRAL-LIKE ASPARTIC PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027284336.2"/>
        </source>
    </evidence>
    <sequence length="354" mass="38762" checksum="7FFB3FE8EBE303B0" modified="2023-06-28" version="1">MLAGGRDQGVELLEQRRMRSPGGPGWASKRPCAESRTQTACLCVQQPARHPVPAPFNLPRLGKYTALSTEALLSSVIAPTLLCAFLYLACAAAELPETTRGMATSRARSQEGHREHAFIPEPFNGANVAPSLWLHRFEVIDDLNHWDHATKLRFLKESLRGDALDVYNGLNSQAQGDYSTVKEALLRAFGGSGTAHSQKPREILFANSMGKGYYLKGKIGPVPVRFLVDSGAQVSVVHPSLWEEVTDGDLDTLRPFENVVKVANGAEMKILGVWDTEVTLGKLKLSAQFLVANASAEEAIIGTDVLQDHNAVLDFQHRTCTLKGKKFRMLPVGGPLEEEFDLELIEEEPLEGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GI77</accession>
    <name>A0A9J7GI77_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor HES-7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hairy and enhancer of split 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">bHLH factor Hes7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC113836790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027282853.1">
        <property type="nucleotide sequence ID" value="XM_027427052.2"/>
    </dbReference>
    <dbReference type="GeneID" id="113836790"/>
    <dbReference type="KEGG" id="cge:113836790"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000063">
        <property type="entry name" value="transcription factor HES-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="14">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="15">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027282853.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25009" checksum="2312FD8B497AB018" modified="2023-06-28" version="1">MVTRDRAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVEPPGAPRSPGQDAEALASCYLSGFRECLLRLAAFAHDASPAARSQLFSALHGHRRPKPPRPEAVDPGLPAPRPPLDPASPILGPAALHQRPQVHQGPPSPRCAWSPSRCSPRAGDSGAPAPLTGLLPPPPLPYRQDGAPKXPPLPPPAFWRPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GPK9</accession>
    <name>A0A9J7GPK9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Segment polarity protein dishevelled homolog DVL-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Dvl1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295209.1">
        <property type="nucleotide sequence ID" value="XM_035439318.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316718.1">
        <property type="nucleotide sequence ID" value="XM_035460827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GPK9"/>
    <dbReference type="GeneID" id="100770288"/>
    <dbReference type="CTD" id="1855"/>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000005">
        <property type="entry name" value="Segment polarity protein dishevelled DVL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000001">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000040">
        <property type="entry name" value="segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000014">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024580">
        <property type="entry name" value="Dishevelled_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008339">
        <property type="entry name" value="Dishevelled_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF5">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02377">
        <property type="entry name" value="Dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12316">
        <property type="entry name" value="Dsh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01760">
        <property type="entry name" value="DISHEVELLED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01761">
        <property type="entry name" value="DISHEVELLED1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DIX" evidence="11">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="289"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="10">
        <location>
            <begin position="463"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035295209.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="79889" checksum="04A8E57C0EBDFF47" modified="2023-06-28" version="1">MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGLWLFSPWLDLQCLVAGLLCFWWALCKCLMFHLVTMAAEVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNRDEASRTNGHPRGDRRRDLGLPPDSASTVLSSELESSSFIDSDEEDNTSRLSSSTEQSTSSRLIRKHKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAITRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFRERREARKYASSMLKRGFLRHTVNKITFSEQCYYVFGDLCTNLASLNLNSGSSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSAGSQQSEGSKSSGSTRSSHRTPGREERRAAGAGGSGSESDHTAPSGSGSTGWWERPVSQLSHGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQP7</accession>
    <name>A0A9J7GQP7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 345 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100756278</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289756.1">
        <property type="nucleotide sequence ID" value="XM_027433955.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GQP7"/>
    <dbReference type="GeneID" id="100756278"/>
    <dbReference type="KEGG" id="cge:100756278"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000003">
        <property type="entry name" value="Zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000475">
        <property type="entry name" value="zinc finger protein 32 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000992">
        <property type="entry name" value="Zinc finger protein 320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GR84</accession>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">17A/GY</strain>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">17A/GY</strain>
        </source>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="10">17A/GY</strain>
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        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GRI5</accession>
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        <submittedName>
            <fullName evidence="13">Sorting nexin-9 isoform X2</fullName>
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    <gene>
        <name evidence="13" type="primary">Snx9</name>
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    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Chordata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035296316.1">
        <property type="nucleotide sequence ID" value="XM_035440425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GRI5"/>
    <dbReference type="GeneID" id="100773889"/>
    <dbReference type="CTD" id="51429"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07668">
        <property type="entry name" value="BAR_SNX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07285">
        <property type="entry name" value="PX_SNX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11898">
        <property type="entry name" value="SH3_SNX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000032">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037425">
        <property type="entry name" value="SNX9_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014536">
        <property type="entry name" value="Snx9_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037426">
        <property type="entry name" value="SNX9_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035558">
        <property type="entry name" value="SNX9_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF2">
        <property type="entry name" value="SORTING NEXIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027744">
        <property type="entry name" value="Snx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="313"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR027744-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035296316.1"/>
        </source>
    </evidence>
    <sequence length="658" mass="73322" checksum="B0214BB581CBC620" modified="2023-06-28" version="1">MESLSVQAKKPRPDLSLGETPCRRQDLPAREQEAIARPGLAVYVALAVVSPQAPRPLRSSPAEARGSQARVMYDFAAEPGNNELTVSEGEIITITNPNVGGGWLEGRNNKGEQGLVPTDYVEILPSDGKDQFSCGNSVADQAFLDSLSASTAQANSSSANSNNQVGGGNDPWSAWNAPKSGNWDSTDAWGTRTDGAGAQRNSANNWDTAFGHPQAYQGPATGDDDEWDEDWDDPKSSSSYFKDSESTEAGGIQRGNSRPGASSMKLPLNKFPGFAKPGMEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVVSESEVFQQFLNFRDEKEWKTGKRKAEKDELVGVMIFSTMEPEAPDLDLIEIEQKCDAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGAHKGAIEKVKESDKLVATSKITPQDKQTMVKRVGTMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALGRFPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUI7</accession>
    <name>A0A9J7GUI7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Supervillin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Archvillin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">p205/p250</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">Svil</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function.</text>
    </comment>
    <comment type="function">
        <text evidence="20">May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Associates with F-actin. Interacts with NEB. Interacts with MYH9. Interacts with MYLK. Interacts with TASOR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with TRIP6. Interacts with DYNLT1. Interacts with KIF14; at midbody during cytokinesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Invadopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035298668.1">
        <property type="nucleotide sequence ID" value="XM_035442777.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313404.1">
        <property type="nucleotide sequence ID" value="XM_035457513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762636"/>
    <dbReference type="CTD" id="6840"/>
    <dbReference type="OrthoDB" id="28894at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043034">
        <property type="term" value="C:costamere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11280">
        <property type="entry name" value="gelsolin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000017">
        <property type="entry name" value="Supervillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000013">
        <property type="entry name" value="supervillin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.950.10:FF:000003">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000015">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000016">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000022">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF45">
        <property type="entry name" value="SUPERVILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="27">
        <location>
            <begin position="2149"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="182"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="486"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="586"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="643"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="743"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="895"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00063352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00069763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00078566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00082677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_035298668.1"/>
        </source>
    </evidence>
    <sequence length="2212" mass="248456" checksum="9D430586D485F80B" modified="2023-06-28" version="1">MKGHQKRPDFNKKNLGFIGFPHQRRSESFQKEFCLDDKEEPANHRRGLDAKCLAALPKVAELRKIFEPKRKDFLEMKRKERIARRLEGIENDPQPILLQSCTGLVTHRLLEEDTPRYMRATDPASPHTGRSNEEEDTPGSSLEKQTPSKYCTETSGIHSSSSMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYAKSRKDPDTGERRGKGDKQEEPSKDIGSLHSRAEPGPRTSLIESQDRTSLGSNMSDQELLLNLENQRRVQEPPVTEDGSPAFFSERGTSFPEVPRSPKQMSSSPLQQPTSPSHPSDSPVPAEARASTGKATHEWFLQKDAEGDTPSLINWPSRVKVREKLVKEESAPSSPELTSESLTQRRQQPGPAHFLSIQSESSAFNRVTSKVVSSLRPSRSCVLPADPVHAIKLVTVDTPESTSECSWVESTTPNVIKSTTLKILEGGSRNAPGLRICESKAKDVLAPETPERSPKSLLTSEDDSLVRGHEDPSGNEDLDESTIHSIAVEPERERRIQQQPTQRTDRSAMVLYVQSGPVSQDATLTSHTKEASPKKRKVLARSLSDYTGPPQLQAPRHKDVAPNQELELRSSRAEGPGAEASMLDTRVSVAQLRNVFLESARASKKPELQSRVERSAEGIGLPTERERGSRKPRRYLSPGESRKTSERFRTQPITSAERKESDRYPSGSEVPMVEDEEKVDERAKLSVAAKRLLFREMEKSFDEHNVPKRRSRNAAVEQRLRRLQDRSHTQPITTEEVVIAATLQAHQKALARGQANEGRESAEPGEPDSSTLSLAEKLALFNKLSQPVSKTISTRKRIDVRQRRMNARYQTQPVTLGEVEQVQSGKLISFSPTVNTSVSTMTSAVAPTYAGDLRTKPSVDDGTSTTDYKFPSPVENSDSPVRSILKPQAWRPLAEPSGSKGILGESGETESKSALTEVDSGVQSYRAFEEEAEPSYPILGRAREGDGQKEPKHAILRRGSLELGNPSVSHLGDEVKEFSTAKSGLQENLDLKDKQTSEEDVDVENGMRKFSLKAAEFEEPASEQTEPAAGKASMQTATPVSWKQQDSSEQLAEKLFKNPCAMFAEGEVKVPVGETFLDSPSKTMSIKERLALLKKSGEEDWKNRLMRKQEYGKATSGLHIQEMEQSLRKRVTESRESQMTIEERKHLITVREEAWKTKGRGAANDSTQFTVAGRMVKKGLASPTAITPVSSPLCSKSRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVAGMQETVLTVTGKSVKEVMKLDDDETFAKFYRSMDHNIPRSPVELEEDFDVIFDPYAPKLTSSVAEHKRSVRPKRRVQASKNPLKLLAARDDLLQEYTEQRLNVAFMESKRMKVEKMASNSNFSEVTLAGLASRENFSSVSLRSVNLMEQNSNNSAVPYKKLMLLQIKGRRHVQTRLVEPRASSLNSGDCFLLLSPQYCFLWVGEFSNVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYETAIIETNCVYRLTDDKLVPDDDYWGKIPKCSLLQSKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRVTEHNETILFKEKFLDWTELKRPTEKNSGEAVQQKDYSRADIKPYDVTRMVATPQMTASTILDGVNVGRGYGLVEGDDRRQIEIATVSVDVWHILEFDYSRLPRQSIGQFHEGDAYVVKWKYMASTAVGSRQKGEHPVRVAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPMEGNLLEVACHCSSLRSRTSMVVLNINKALIYLWHGCKAQGHTKEVGRTAANKIKEQCPLEAGLHSSSNVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFSATEFVYPARAPSAVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPTENKITGSARIRWASDRKSAMETVLQYCRGKNLKRPPPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEFNALPTWKQVNLKKAKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUJ4</accession>
    <name>A0A9J7GUJ4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fibronectin type 3 and ankyrin repeat domains 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Fank1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with COPS5; regulates the phosphorylation of JUN and the transcriptional activity of AP-1. Interacts with RYBP; may prevent the ubiquitin-mediated proteasomal degradation of FANK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035298041.1">
        <property type="nucleotide sequence ID" value="XM_035442150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GUJ4"/>
    <dbReference type="GeneID" id="100760059"/>
    <dbReference type="CTD" id="92565"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000598">
        <property type="entry name" value="Fibronectin type 3 and ankyrin repeat domains protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035298041.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39792" checksum="C2EE34C6D1B57708" modified="2023-06-28" version="1">MEPHRLRTEPRALRLLEIVPSIKPHPPVVGKVTHHSIELYWDLEKKDKRQGPQEQWLRFSIEEEDPRMHNYGVIYTGYSTKHVIEGLEPRTLYKFRLKVTSPSGEYEYSPVVSVATTREPISSEHFHRAVNVNDEDLLLRILEGGTIKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWDARDLGGCSALHWAADGGHCPVIDWMIKDGCEVDVVDTGSGWTPLMRVSAMTGSQKVASLLIEAGADVNVKDKDGKTPLMVAVLNNHEQLVQLLLEKGADASVKNEFGKGVLEMARVFDRQNVISLLEERKKKLPRKSSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H3U2</accession>
    <name>A0A9J7H3U2_CRIGR</name>
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        <recommendedName>
            <fullName evidence="2">Tumor protein p53-inducible protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">p53-induced gene 11 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tp53i11</name>
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    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035295843.1">
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    </dbReference>
    <dbReference type="RefSeq" id="XP_035302869.1">
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    </dbReference>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028266">
        <property type="entry name" value="TP53I11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31584">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31584:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14936">
        <property type="entry name" value="p53-inducible11"/>
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    </dbReference>
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        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00019449"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035302869.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22438" checksum="DF2313FF1A78A0D9" modified="2023-06-28" version="1">MAEASVSPCPSAEDNMAAKQPPPLMKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFAVREPLGLRVWQFLSAMLFSSVAIMALALPDQLYDAVFDGAEVTSKTPIRLYGGALLSISLIMWNALYTAEKVIIRWTLLTEACYFGVQSLVVTATLAETGLMPLGTLLLLASRLLFVIVSIYYYYQVGRKPKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4P7</accession>
    <name>A0A9J7H4P7_CRIGR</name>
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        <submittedName>
            <fullName evidence="14">Zinc finger protein 39-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC118239142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035303447.1">
        <property type="nucleotide sequence ID" value="XM_035447556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4P7"/>
    <dbReference type="GeneID" id="118239142"/>
    <dbReference type="KEGG" id="cge:118239142"/>
    <dbReference type="OrthoDB" id="9558250at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002175">
        <property type="entry name" value="Zinc finger protein 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002004">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="12">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035303447.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="61954" checksum="B5619558461D346F" modified="2023-06-28" version="1">MNTVVGLVTFEDVCVDFTWDEWQDLDDAQRKLYREVMLETYRSLLSLNQCDAKPELILKLEQGAGPWKEEDAPNQRLPAMENGKSLNDTSWDNQKRYLNYLVITGNSSTEERVKFGELFNMSSNHVLRLAIKNRNSSKMRSEVLDIWESVYLPSEHSEMQPIEELDPTTTRMSCGPPEPLSLDHRVESGQQHFQCSHHDEAFSMNSVWTHKVFPLGDNSSKLKECKLALSAQEGTHITEEIFDCNFCKKSFSDKCSHTQHLKTCIKNKCDKRTDCEPAFHTKPGLVNLQSNLHAWEKACVCNDNEKCVCQMPKQRVNQSVFSSKESHCVKKISVHQRPHTGRKPHECNTSAKISKQPRRRHRCGRSYQCKVCGKAFKHTQNLYLHYRTHTGEKPYECKECKKLFSVKSNLSVHQKTHTGEKPYECNICGNAFKRRCDLTIHQRVHTGEKPYECKECRKTFSIKSGLIVHQRIHTGEKPYECNVCGKRFNQKSNLSTHEKIHTGEKPFECKECRKSFSVKSYLTIHQKTHLGEKAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4R4</accession>
    <name>A0A9J7H4R4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Complexin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Cplx1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complexin/synaphin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303487.1">
        <property type="nucleotide sequence ID" value="XM_035447596.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311698.1">
        <property type="nucleotide sequence ID" value="XM_035455807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4R4"/>
    <dbReference type="GeneID" id="100771100"/>
    <dbReference type="KEGG" id="cge:100771100"/>
    <dbReference type="CTD" id="10815"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22740">
        <property type="entry name" value="Complexin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.580:FF:000001">
        <property type="entry name" value="Complexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF6">
        <property type="entry name" value="COMPLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035303487.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14896" checksum="90570713D2D0BBC5" modified="2023-06-28" version="1">MEIAAYVMGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREVMRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEPEEEDESILDTVIKYLPGPLQDMFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4U8</accession>
    <name>A0A9J7H4U8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100755740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035305051.1">
        <property type="nucleotide sequence ID" value="XM_035449160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755740"/>
    <dbReference type="KEGG" id="cge:100755740"/>
    <dbReference type="OrthoDB" id="9427497at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032396">
        <property type="term" value="F:inhibitory MHC class I receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002764">
        <property type="term" value="P:immune response-regulating signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16843">
        <property type="entry name" value="IgC2_D1_D2_LILR_KIR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000049">
        <property type="entry name" value="Leukocyte immunoglobulin-like receptor subfamily B member 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050412">
        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738:SF179">
        <property type="entry name" value="LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738">
        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039918807" evidence="11">
        <location>
            <begin position="19"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="521"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035305051.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="73078" checksum="C2ECC45E42B3D3E3" modified="2023-06-28" version="1">MTVSFTALLCLGLTLGHGTPVLAGTLPKPILRVQPESVVSVQTTVTFLCEGTKGAQXIRLYNNTNQYLTYRETIPNTKNRAEFSISKIAPLDAGRYHCQYWTRDGRSEHSDTLELVVTGAYSKPSLSAHPSPVVTEGGSVTLKCVSRQPYHKFFQTKAGPQKVFWTRNSEFNYSTWQYQAQLRVDALTSSQRWTFRCYSCDSNRPLVWSEPSDPLELLFSGTLHKPTIKAEPGPVIALESAVTIWCQGTLDAEMYVLHKEGSQKPWGTQSPEEPGKRAKFSIPYVTQKHAGQYRCYCYSSAGWTERSDTLEIVVTGMYNSKPSLSALPSPVVTSGGNMTLQCVSRVRYDKLILTKEDEKFSSSLDSQYINNRGHYKATFSMGPVTPVHRGTFRCYGYLKDTPQLWSAPSEPLKIYISGLSKKPSLLTHQGHILDPGKSLTLQCCSDYDRFALYKVGGADFTQHYGQRTQGNFSSATFTLGYVSSSTAGQYRCYGAHNQSSEWSSSSDPLDIMISGQLPDSPSLSVKPNSTVQSGDNVTLLCQSTYTTDTFILSKEGAAHQPQRMKSKSQDGEFQAEFSMTAVTSALSGTYRCYSSRGSYPYLLSHASGPVELSVSASEIKDYTVENLIRMGLAVLVLKVLGILVLESWRSQKQSHHVAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H725</accession>
    <name>A0A9J7H725_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">StAR-related lipid transfer protein 8 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Stard8</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035306133.1">
        <property type="nucleotide sequence ID" value="XM_035450242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H725"/>
    <dbReference type="GeneID" id="100755250"/>
    <dbReference type="KEGG" id="cge:100755250"/>
    <dbReference type="CTD" id="9754"/>
    <dbReference type="OrthoDB" id="10003330at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000007">
        <property type="entry name" value="rho GTPase-activating protein 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000009">
        <property type="entry name" value="StAR related lipid transfer domain containing 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659">
        <property type="entry name" value="RHO-TYPE GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659:SF3">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="582"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="831"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035306133.1"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114612" checksum="13A3B515E1D8A1AF" modified="2023-06-28" version="1">MTLNNCASMKLEVHFQCKQDEDSEEEEQCTISSHWAFEQESKCGSPMGSSGLLAPPTSSLLGTSSCESVLTEISAASLPAISVSRSPESADLSLIDRVPSPSNRSFLRPSQGQEGSQDKVKKHYSRSFLKHLESLRKKEKGDSQQTEPEKRLTTSEKATKASSFRSCRGFLSAGFYRAKNRATTSSRGRDGETQKAWEAWPIATLRHPQPVRRRDYLVHVPGDHKPGTFPRSLSIESLCPDDEHHLADWQPGRCWGYEGRRGSCGSTGSHASTYDNLPELYPAEPIQAEAEAEAEAEAEAEAEDEEGECSYAHLDDILEHVWGLQQRVELWSQTMYPELRPADKDEEEEEEEEEEASSSVEIATAEVEGQDEDLGQAESQAHKEFPPQAKDEVPLTTLAQTPTVVKQLVQAETEAKAPAPAQAQDHEQEANSATEPTSVSSLSVEEGQSISDTAVSSSELDSSGNSMNEAEGAEALVGLQASVPRERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTGFMEKYTVPHKQAWVWSMPKFMKRNKTPDYRGHHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQSLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKEQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLVGRPGPRDLSENMAATQGLSHMISDCKKLFQVPQDMVVQLCGSYSAAELSPPGPALAELRQAQAAGVSLSLYMEESVQELLRDAAERFKGWTNVPGPQHTELACRKAPDGHPLRMWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H913</accession>
    <name>A0A9J7H913_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Double-stranded RNA-specific editase 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">Adarb1</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
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    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
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    <reference evidence="14 15" key="3">
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            <authorList>
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                <person name="Dhiman H."/>
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                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
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                <consortium name="RefSeq"/>
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            <strain evidence="9">17A/GY</strain>
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    </dbReference>
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            <begin position="103"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035306298.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18595" checksum="B4EC97D3A229D94C" modified="2023-06-28" version="1">MAPPVSFTAQTAFDSQQSSCLSFLSARKTCGNHHYNRRGTWFSLKCWEVLAPGRETSGSLAGHTAPGRDPKHRPSRCCTRCSRQGPWAVRGNYKGHPRQLPLATMRALLLLLLLLLLPTLELALRSRQSPEARDKLCGHHLVRALVRVCGGPRWSSEASQPADARDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HBD0</accession>
    <name>A0A9J7HBD0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAC-alpha domain-containing protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Nacad</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035309083.1">
        <property type="nucleotide sequence ID" value="XM_035453192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769774"/>
    <dbReference type="CTD" id="23148"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:myoblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14416">
        <property type="entry name" value="UBA_NACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGD2/NACA0like"/>
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        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041907">
        <property type="entry name" value="NACAD_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="1364"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="967"/>
        </location>
    </feature>
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            <begin position="989"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1120"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
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        <location>
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            <end position="706"/>
        </location>
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            <end position="888"/>
        </location>
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            <end position="1237"/>
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            <end position="1286"/>
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        <location>
            <begin position="1320"/>
            <end position="1329"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035309083.1"/>
        </source>
    </evidence>
    <sequence length="1514" mass="158033" checksum="AD2F3ACF91692B57" modified="2023-06-28" version="1">MPGEAARAELPLPEAGGPGSRTDLSCDAAIATILKGDQQEPLPLTPGPSPLALAFLSSKPGARPQPEGASWDAGPSGAASTWVDPAEGSPSPGVLPEGLPLQPLPAEVPLPTTLEPRIVMGEETCQVTPLPRAAWPVLRDREGGHMALHPPPELCSQGDPPVPSPPPDLDSYFTPPSTPTKTTYALLPDHGPHRDTWDLEAELLDELLDSTPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSDWGLSPSGSVVDELEPQPTEAPEPPSSESSLSTDSSSSWSQEGHFFDPTFLANDPMIPAALLPFRGSLIFQVEAVEVTPLPQEEEEEEVVAGAATPDGDLAGEGEDDSTSASFLQSLSDLSIIEGMDEAFAFRDDTSAASSDSDSASYAGADDDRLYSGEPHAQPSAQNTEQEHRSRATFQGTEFMPQISEQETCLTNSQESIADIAEEAPTLGIESEATVTLPDLQEAPGPQMEGATTVTPRVGNKEVDSVAQQAPRALPEPCRKGMGTSSGCKPVTVESILDLQEEASPTLCPILPANLKEGGQGLPSTLEYVTVASVRPQKAEGGITIPQDHPMTLPPFLQCVDPTSGPESVAVVTLRLQQDKGCVIALQEAPVASPLPLQSTDPTSGPESRAVATCGPQQAKEGTTAPQDSPMASSPPPQGSEPTSDPEPEAVVTLGSQQAKEGTTAPQDSPMASSPPPQGSEPTSDPEPEAVVTLGSQQAKEDTTAPQDSPMASSPPPQGSEPTSDPEPEAVVTLGYQQDKGTTAPHGSPMACLSLQGSDPTPDPESELAAILEPQQAKEGVTIPQLAPVASPSPLRSLDSILDLQPVATATLESQQAKGSTTVPQDTFVVAPPSLQGTDSTSEPELIVQDTSPALQRETCYTPEIKPSASEAHQELGVALGPKPVPEEQDSEPTLDSALTTSNQAQQNGSQPAVKADNAGAPEESCPTLSTKVSEPISCMGEKVAESIPALRQGAHLEAHGGVKTCSPQREAPGAKNKRGRCPKPLGQGNGSKSASQGAGKTSKAQSASCTEVSQTQLMSLAREGRGLNSKDTLGPKLPVALSVQARLGSCPDSPARATCTLSGVHSEETARSAQSFEQLEPVLGLGSRDQPQTTPGALNPSPANSVSDLPTTPQDRSLDPDPPASNDLNRASQTSPGPPASCLCPTPQKASVEEEEPSASHGLMPRAGAQGTAAITTSGSTMPLGARHRVSLSPHSTLNPKVTPTDAKDLACIISSPCQVPPPSGTQNPSGPRGFPAHQQEDEDSLEEDSSQGDTTGWDWRNLGNSKRPSYLTPFPDSQRAPGSGQHSDSQGESSAELDEQEIPSQKAQCPAQGPTGSNEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSESSALVPELAPGPRVRPQCEEQEEEDEEVEEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCG6</accession>
    <name>A0A9J7HCG6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ephrin-B2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118239749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309421.1">
        <property type="nucleotide sequence ID" value="XM_035453530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCG6"/>
    <dbReference type="GeneID" id="118239749"/>
    <dbReference type="KEGG" id="cge:118239749"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048514">
        <property type="term" value="P:blood vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF18">
        <property type="entry name" value="EPHRIN-B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039942598" evidence="8">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="9">
        <location>
            <begin position="31"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035309421.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17414" checksum="86C1DC2D196A7DD6" modified="2023-06-28" version="1">MSMSRLRRDSAWKYCWGFLMVFCRTAISSPTVLEPIYWNSSNSRFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKLYMVDKDQADRCTIKKKNTPLLNCSIPQQDVKFTIKFQEFSPNICGLEFQENKDYYIIWANLPGFLWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCM7</accession>
    <name>A0A9J7HCM7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113838914</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035309799.1">
        <property type="nucleotide sequence ID" value="XM_035453908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCM7"/>
    <dbReference type="GeneID" id="113838914"/>
    <dbReference type="KEGG" id="cge:113838914"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035309799.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21619" checksum="AD5E7171FFBE812A" modified="2023-06-28" version="1">MSEYKLVVVGADGVGKSALTIQLIQNHFVDVYDPTIEDFYRRQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFSMNNTKSFEAIPHYREQIKRAKDSEDVPMVLVGNKCDLPSRTVDTNQAQDLAGSYGIPFIETSAKTRQRVEDAFYILVREIRQYRLKKISKEEKTPGRVKNKKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCR8</accession>
    <name>A0A9J7HCR8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein C6orf132 homolog isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CUNH6orf132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035307884.1">
        <property type="nucleotide sequence ID" value="XM_035451993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772166"/>
    <dbReference type="KEGG" id="cge:100772166"/>
    <dbReference type="CTD" id="113417010"/>
    <dbReference type="OrthoDB" id="9945848at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35077">
        <property type="entry name" value="SIMILAR TO AI661453 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35077:SF2">
        <property type="entry name" value="SIMILAR TO AI661453 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035307884.1"/>
        </source>
    </evidence>
    <sequence length="1180" mass="125076" checksum="D20E75375DEC5CD5" modified="2023-06-28" version="1">MKKSQTMQGTFSKLFGKKHTNSAATSLYATNPPWIFTQEAQEEGTRDFDGIYYGDSRFNTVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPEDFADKEVGGTSSLVNGNLRLYSSVGDLRPVHYDLESSIPPPPPGPAPGPPQDSPQSPAESPPPPPPSIPPPPPPLLXEPPPHPAQPPPPTPVLDTSSTLSPPSTPTPPDFIPPAPPSTFLNPPIPSLPVPGPPSPVSPHTAGMCLLPSGGIIKWKSEVALNGRQPEDPRTSPPKSPAELKGSPLGPTPESHLTFPRSFKVPPPTPVRTSSIPVLEAPGASPEEEEASLPLPSSFSIRPASQVYPDRALEPEHQREPRLETPGSPRLKQSEPQTNGQAGVPPPAPPLPPPAPPLPPPAPSLPPAAPPLPSTEQAVPPSSGFTNIPKSSSPTPNSKPDPPTLEDTDSSEPVDWRDPRQMEKLRSELSAYLCGSRKEDRSLGHRPVSMVALKDKESKKGSSLSEAAAPPSLPEKIHPCGSEKSPSSNHLSERKTTSSPTLPPVDYIPQGTTAPSVKQIRNELEARFASSAEKEAKPSIASLPPKPRLEGGRIFENGTDNGRLHKPVTKNPPQLPATPLSATPLQSKITPGPAAPPKATPRPATPPKDPPGQTTPPKHTLGKATPPKDLPGQTTSTKHPPGQDTSTKDTPELSIPSSQLMAEKDLVPVRQREKPESQENAVATQLSTNGTLSPPALPPKMSTGGEEVPFLYKPHRSHNTHSRGVAVVIPTRARGEATDSGGLVDEKEPQRHPAKPLTQVQPADQLLRHPVTGEVVERGSPMALLLAARQRAQKGRPGGTAMGLGRSSLPGSLRNHSNQTEASSDSIFYRGSRPNSFLVVPKAPSETEDSHRTSARPAGPSQWKPQQGRDIQGPEPSHRHGWTKAESPAVASVARERQAPSSLPQGGALPKSFSSPPSPSYKREEEEEEFCFDIIPPPPEFSNDPEPPALELQHRSRQGSPPTNNFSDLGQSLDAGPGANPARSFSRFSGAQYSGFGGLDRLSGSGRSLIKKRLYVGEPHHNPGTPRGATGRSMSSPNCFGPQPGGPETRRVNSAGRAAPGGLNARRLSLEGSRGTAEVKYKLPSGGGGNGSKPGDYGFVPAKGTRSLHGTTHYGSPINTFTVRPGTRHPISYNYSGTHRKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HFQ5</accession>
    <name>A0A9J7HFQ5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC113839062</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC113839062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035309631.1">
        <property type="nucleotide sequence ID" value="XM_035453740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HFQ5"/>
    <dbReference type="GeneID" id="113839062"/>
    <dbReference type="KEGG" id="cge:113839062"/>
    <dbReference type="OrthoDB" id="9634693at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09273">
        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039464">
        <property type="entry name" value="Gag-pol_Znf-H3C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16721">
        <property type="entry name" value="zf-H3C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="53"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="321"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035309631.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44269" checksum="42A9520A5AF33361" modified="2023-06-28" version="1">MLLDKDRVHFGPLVTLNPATLLPLPGEPEAHDCLQVLAEAHGARPDLTDQPLPSPDHIWFTDGSSFLHQGERRAGAAVTTENQVVWAQALPPGTSAQRAELIALTQALKLAEGKRLTVYTDSRNAFATAHIHGEIYRRRGLLTSEGKDIKNKEEILALLRALHLPAALSIIHCPGHQKGDSFEARGNRRADLAAREAALTTDTTNLLALEPTNDHPSPSWDYEQRDIQTLEKLGATKEPNGDWTYEGKTVIPYRVTKYLVTFLHKMTHLSSKKMRELLEREEEFNFLLGKNDILKQVTEQCDACARVNASRLKLPPGNRVRGYRPGTHWEIDFTEIKPGKYGYKYLLVFVDTFSGWVEAFPTKHETAKIVTKKLLEEIFPRYGMPQLIYRPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J860</accession>
    <name>A0A9J7J860_CRIGR</name>
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        <submittedName>
            <fullName evidence="13">Zinc finger protein 704 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Znf704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027254574.1">
        <property type="nucleotide sequence ID" value="XM_027398773.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J860"/>
    <dbReference type="GeneID" id="100770107"/>
    <dbReference type="KEGG" id="cge:100770107"/>
    <dbReference type="CTD" id="619279"/>
    <dbReference type="OrthoDB" id="5950721at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052253">
        <property type="entry name" value="CR1/CR2-DNA-binding_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006">
        <property type="entry name" value="PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006:SF7">
        <property type="entry name" value="ZINC FINGER PROTEIN 704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="501"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027254574.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="61515" checksum="8568ED8B2B8F7BF4" modified="2023-06-28" version="1">MQARRLAKRPSLGSRRGGAAPAPTPEAAALGLPPPGPSPGAAPGSWRPPLPPPRGTGPPRAAAASSPVLLLLGEEDEDEEGAGRRRRARGRLAEKPRGGAEEDDDDEEEDEEVVVEVVDGDEDEEDAEERFVPLGPGRALLRGPARGAVKVGGFKREMTFTFQSEDLKHDSSKKPSHHMFPLAMEEDMKTVDTKKANRILDQEKENTRSICLLEQKRKVVSSNIDVPPARKSSEELDMDKVTAAMVLTSLSTSPLVRSPPVRPNEGLSGSWKEGAPSSSSSSGYWSWSAPSDQSNPSTPSPPLSADSFKPFRSPAPPDDGIDEAEASNLLFDEPIPRKRKNSMKVMFKCLWKNCGKVLNTAAGIQKHIRAIHLGRVGESDYSDGEEDFYYTEIKLNTDSVAEGLSSMAPLSPSQSLASPPTFPVPDSSRTETPCAKTDTKLMTPLSRSAPTTLYLVHTDHAYQATPPVTIPGSAKFTPNGSSFSISWQSPPVTFTGIPVSPTHHHPVGSGEQRQHAHTVLSSPPRGTVSLRKPRGEGKKCRKVYGMENRDMWCTACRWKKACQRFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J9V6</accession>
    <name>A0A9J7J9V6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LOW QUALITY PROTEIN: sorting nexin-25 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Snx25</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027246904.2">
        <property type="nucleotide sequence ID" value="XM_027391103.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100769737"/>
    <dbReference type="KEGG" id="cge:100769737"/>
    <dbReference type="CTD" id="83891"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06878">
        <property type="entry name" value="PX_SNX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000033">
        <property type="entry name" value="Sorting nexin 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037899">
        <property type="entry name" value="SNX25_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF48">
        <property type="entry name" value="SORTING NEXIN-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="149"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="438"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="658"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027246904.2"/>
        </source>
    </evidence>
    <sequence length="990" mass="112837" checksum="5FD324EC793EDE5B" modified="2023-06-28" version="1">MSLSPSGPGSSMHRDATDSSGVRRGPTPAADAGRAAPGSADXPGRGWRGPAAVAALAALALCCLVPGWGPAAGAGPGALLLRLSLYLSGAAAAWLLGTLIALVYWSPRARPPDFASSWSRLAVAVRCPLRSPVCGNPQETSQGRKVVISHNMDRALKDVFDYTYRDYILSWYGNLSRDEGQLYHLLLEDFWEIVKQIRHRLSHMDVVKIVCNDVVKALLTHFCDLKAANARHEEQPRPFVLHACLKDSRDEVRFLQTCSRVLVFCLLPSKDIQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLLAQLEYREQMNEHHKRAYTYAPSYEEFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKGKESAAMKTDLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYEQQEDGTLDEGEGLQSQKILQFEEIMTNPFYRERFGTYMERMDKGTLIGFWESVEHLKSANKNEIPQLVGEIYQNFFVESKEIPVEKSLYKDIQQCLVGNKGIEVFSRIQADVYEALRDRYYPSFIVSDLYERLMMKEEEKQDAQQTSDKDELGSGSEAGEEAIEGTSGICDQASFAVNKLRELSEKLEYKRQALSSIQNAPKPDKKIISKLKDEILLIEKECTDLQLHMARTDWWCENLGLWKAAITSAEVTEENGEQMPCYFVKVNLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDHKFLEKSKNQLNKFLQNLLSDERLCQSEALYAFLSPSPDYLKVIDVQGKKPSFSLSSFLEKLPRDFFSHQEEEMEEDSDLSDYGDDVDGKKDALAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVNWIFSEQMLVYYINTFRDAFWPNGKLAPSTRIRSEAQSQETKQRAQQKLLENIPDTLQSLVGQQNARHGIIKIFKALQETRANKHLLYVLMELLLIELCPELRTHLDQFKAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JD22</accession>
    <name>A0A9J7JD22_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">PLAC8-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Plac8l1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027253797.1">
        <property type="nucleotide sequence ID" value="XM_027397996.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293012.1">
        <property type="nucleotide sequence ID" value="XM_027437211.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JD22"/>
    <dbReference type="GeneID" id="100762432"/>
    <dbReference type="KEGG" id="cge:100762432"/>
    <dbReference type="CTD" id="153770"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027253797.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24861" checksum="28F8406EF2557D49" modified="2023-06-28" version="1">MTSGSRISRQHSFKGMLHFGLNPNSEPVSLLFKGKDNQTRRHLVMIWPGHYFSRCPEDVSLFGTHMPLFSLMSSGDEHLLSNLRSQVPARAVVKQPIRGASGRTTVTAIVQTGGDWSTGLFSVCRDRKICFCGLFCPICLECDIARHYGECLCWPLLPGSTFALRIGTRERHKIQGTLCEDWMVVHCCWPFSVCQVARELKIRTSQLYEICAVQAPKDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JFS6</accession>
    <name>A0A9J7JFS6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear factor related to kappa-B-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-binding protein R kappa-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Nfrkb</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFRKB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007642739.1">
        <property type="nucleotide sequence ID" value="XM_007644549.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267554.1">
        <property type="nucleotide sequence ID" value="XM_027411753.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100756883"/>
    <dbReference type="KEGG" id="cge:100756883"/>
    <dbReference type="CTD" id="4798"/>
    <dbReference type="OrthoDB" id="70874at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033044">
        <property type="term" value="P:regulation of chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051052">
        <property type="term" value="P:regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21865">
        <property type="entry name" value="DEUBAD_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2430:FF:000001">
        <property type="entry name" value="Nuclear factor related to kappaB binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2430">
        <property type="entry name" value="NFRKB winged helix-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024867">
        <property type="entry name" value="NFRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025220">
        <property type="entry name" value="NFRKB_WH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057748">
        <property type="entry name" value="NFRKB_WH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038106">
        <property type="entry name" value="NFRKB_winged_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052">
        <property type="entry name" value="NFRKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052:SF3">
        <property type="entry name" value="NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14465">
        <property type="entry name" value="WHD_1st_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25793">
        <property type="entry name" value="WHD_2nd_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEUBAD" evidence="10">
        <location>
            <begin position="39"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="675"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027267554.1"/>
        </source>
    </evidence>
    <sequence length="1306" mass="140385" checksum="788251FAB4CB8704" modified="2023-06-28" version="1">MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPTDNVEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRHKRHSPSRSPEEREWRTQQRYLKVLREVKEECGDTALSSDEEATLDLQEKFSFEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLSDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEKKKKIKLIKSEAEDLAEPLSNSEGVPTLSQAPSPLAISSIKEEPLEDIKPCLGINELFPSFFSLLLEILLESQASLPMLEDRVLDWQASPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQYQDNEKELAALFHLWLETKDQTFCKQENEDSSDAMTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSNKESSLKGLSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPTTPISPPPVSAVNKSGSTTVSEPAKSSSGVLLVSSPTMPQLGTMLSPTSIQTPPSSQATARVVSHSSSAGLPQVRVVAQPSLPAVSQQSVGPTQTLPQMPAGPQIRVPVTATQTKVVPQAVVATVPVKGQTAAASVQRPAPGQTGLTVNLPAAVSPVSKPAMSSPGNSAPSASTTAVIQNVTGQNIIKQVSITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGSGTAGKGISATLHVTSNPVHATDSPAKAPSASVPSSAPAGTTVVKVTPDLKPTEASNSAFRLMPALGVSVADQKGKNTVASSEAKPAATIRIVQGLGVMPPKAGQTITVAAHAKQGASVAGGSGTVHSSTVSLPSISATVSKTVAVASGATSTPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JGB5</accession>
    <name>A0A9J7JGB5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein KIAA1958 homolog isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Kiaa1958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007644200.1">
        <property type="nucleotide sequence ID" value="XM_007646010.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258800.1">
        <property type="nucleotide sequence ID" value="XM_027402999.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JGB5"/>
    <dbReference type="GeneID" id="100769984"/>
    <dbReference type="CTD" id="158405"/>
    <dbReference type="OrthoDB" id="5957988at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF1">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="560"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027258800.1"/>
        </source>
    </evidence>
    <sequence length="744" mass="82568" checksum="5E3A47FEA9E15A39" modified="2023-06-28" version="1">MEDCLHTSSENLSKLVSWAHSHGTICSLIPNLKHLLSEGSHGNLTAMWGCSAGHAYHWPLTATCRAGSQERVCFQDNRSFNSDSPSIIGVPSETQTSPVERYPGRPVKAKLDCNRTRDSCDFSYCSEPSELDEAVEEYEDENTLFDMVCESSVTDEDSDFEPQTQRPQSIARKRPGIVPSSIHSGSQGQMVDECSNDVIIKKIKQEIPEDYYIVANAELTGGVDGPALSLTQMAKPKLQTHAGPSCVGSAKLIPHVTSAISAELDPHIMSASPSVISRPIIPKTARVSLASPNRGPPGAHGTAHQVTMQMPVSTSHPNKQISIPLSALQLPGQDEQVVSEEFLPHLPSQVSSCEVALSPSVNTEPEVSSSQQQPPIAPTITTEATAQCIPDQDERAAELSREQNEKTIRSTQTALRNFPYSTKLNKFPVFNINDDLNDLCTSAVSPNTTKATRYALNVWRYWCMTNGLKDHTDITKIPAVKLNELLENFYVTVKKSDGSDFLATSLHAIRRGLDRILKNAGVGFSITSSTFSSSTKKLKEKLWVLSKAGMSGARSRNIVYFSLSDEEEMWQAGCLGDDSPITLLSTVVKYNSQYLNMRTLQEHADLMYGDIELLKDPQNQPYFARTDSVKRESRSGSTRVCHGKIYHEHSRGHKQCPYCLLYKYMYIHRPPTQMDAKSPFYLTARKEATDMGNVWYEEQRMGLRSLRGIVPNLARKVKLDNCENFTFVSFTQVSRRLSSHSCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JNC9</accession>
    <name>A0A9J7JNC9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100757681</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003515937.1">
        <property type="nucleotide sequence ID" value="XM_003515889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268050.1">
        <property type="nucleotide sequence ID" value="XM_027412249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JNC9"/>
    <dbReference type="GeneID" id="100757681"/>
    <dbReference type="KEGG" id="cge:100757681"/>
    <dbReference type="OrthoDB" id="9602702at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15405">
        <property type="entry name" value="7tmA_OR8B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000646">
        <property type="entry name" value="Olfactory receptor 887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:001035">
        <property type="entry name" value="Putative olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027268050.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34701" checksum="EC5BA5DEEF07B0B5" modified="2023-06-28" version="1">MVPENGSSVTEFILVGLTKQPNLQCPLFILFLVMYVVTVLGNLGLIILIGLNSHLHTPMYFFLCNLSFVDLCYSSVFSPKMLMSFISEKNIISYRGCMTQLFFFSFFGISECYVLTAMAYDRYVAICNPLMYNIVMSPKLCLNLMLGSYMIAFFGALAHTGCMLRLTFCDANTINHYFCDILPLLQLSCTSTYVNELEVFVVVGINIIVPSITIFISYGFILSSIFHISSAEGRSKAFNTCSSHIIALSLFFGSGAFMYLKPSDAMSMDEGKISSVFYTNTVPLLNPLIYSLRNKDVKVALRKTLSNRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JZ96</accession>
    <name>A0A9J7JZ96_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DENN domain-containing protein 5B isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Dennd5b</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAB6IP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027285844.1">
        <property type="nucleotide sequence ID" value="XM_027430043.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100762143"/>
    <dbReference type="KEGG" id="cge:100762143"/>
    <dbReference type="CTD" id="160518"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01757">
        <property type="entry name" value="PLAT_RAB6IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17691">
        <property type="entry name" value="RUN1_DENND5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17693">
        <property type="entry name" value="RUN2_DENND5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000003">
        <property type="entry name" value="DENN domain containing 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000008">
        <property type="entry name" value="DENN domain containing 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000001">
        <property type="entry name" value="DENN domain containing 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000007">
        <property type="entry name" value="DENN domain-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047278">
        <property type="entry name" value="DEN5A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047277">
        <property type="entry name" value="PLAT_RAB6IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047293">
        <property type="entry name" value="RUN1_DENND5B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047292">
        <property type="entry name" value="RUN2_DENND5B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070:SF3">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="UDENN" evidence="10">
        <location>
            <begin position="59"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="11">
        <location>
            <begin position="794"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="9">
        <location>
            <begin position="958"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="11">
        <location>
            <begin position="1140"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027285844.1"/>
        </source>
    </evidence>
    <sequence length="1296" mass="147796" checksum="378DA3B0C601174D" modified="2023-06-28" version="1">MSGSGARRPGRARPAACRFAHYFVLCGIDADSGLEPDELAVLYQWLEADRHGKSQDTANTTSGENFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQADNKEPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEQYSSVYASSSCSMDSLASSIDEGDATSLLKLQRYNSYDINRDTLYVSKSICLITPLPFMQACKKFLLQLHKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPNELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLLQFGIPPEGSLHCSESATKLKNMVLKDLVNDEKNGNTPTNNISVYEFMKGNETIARLQALADRTGVTVGKIDLSASLNEKEKDFKLQCEEAELRDYQLNVQLREVFACRFIQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDSRIEKIRLYNVRAPTPTLRTSVYQKCSSLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPANNNRWVSRSATAQRRKERLRQHSEHIGLDNDIREKYMQEARSLGKNMRQPKLSDLSPAVIAQTNWKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLTDSPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQLLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLGKQCRTPPQQKSPTTTRRLSITSLTGKTSKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFKSARIFHKNVFIWDFVEKAVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRSIGKDGKFQILVCLGTRDHLLPQWIPLLAECPAITRMYEESALLRDHMTVNSLIRILQTIQDFTIVLEGSLIKGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K0X4</accession>
    <name>A0A9J7K0X4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretogranin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Secretogranin II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Scg2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with Secretogranin III/SCG3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the chromogranin/secretogranin protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035292821.1">
        <property type="nucleotide sequence ID" value="XM_035436930.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295143.1">
        <property type="nucleotide sequence ID" value="XM_035439252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K0X4"/>
    <dbReference type="GeneID" id="100763908"/>
    <dbReference type="KEGG" id="cge:100763908"/>
    <dbReference type="CTD" id="7857"/>
    <dbReference type="OMA" id="RNAAYDD"/>
    <dbReference type="OrthoDB" id="8894600at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048245">
        <property type="term" value="P:eosinophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001990">
        <property type="entry name" value="Granin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038858">
        <property type="entry name" value="ScgII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15119">
        <property type="entry name" value="SECRETOGRANIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15119:SF0">
        <property type="entry name" value="SECRETOGRANIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01271">
        <property type="entry name" value="Granin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039906763" description="Secretogranin-2" evidence="11">
        <location>
            <begin position="24"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035295143.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="70604" checksum="07C8F43ED84C7513" modified="2023-06-28" version="1">MAEAKTHQFGALLLLVLISGAEAASFQRNQLVQKEPDLRLENVQKFPSPEMIRALEYIEKLRQQAHREESSPDYNPYQGISVPLQLKENIEESHLAESSRDALSEDEWMRIILEALRQAENEPQSTPKENKLFALNLEKNFPVDMVDDYETQQWPERKLKHMRFPLMYEENSRENPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRERVDEEQKLYTDDEDDVYKNNNIAYEDVVGGEDWSPVEEKIETQTQEEVRDSKENTEANEQINEEMKRSGQLGLQDEDNRKESKDQLSEDASKVITYLRRLVNAVGSGRSQNGQNGDRAARLLEKPLDAQSIYQLIEISRNLQIPPEDLIEMLRAGEKPNALVEPEQDLELPVDLDDIPEADIDHPDMFQSKLLSKGGYSKVPGHGMIEALPEGLSVEDILNLLGMENEANQKPPYFPNQYSRDKALLRLPYGPGKARTNKIPKAAWMPEVESRQAPYENLINDKDQELGDYLARLLVKYPELLNSNQLKRVPSPGSSEDDLQEEEQLEQAIKEQLGQGSSQETEKLATVSKRLPAGSLKNDDALNRQYLDEDMLMKVLEYLTQEKAEQGKEHLAKRAMENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K1K8</accession>
    <name>A0A9J7K1K8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Mid2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 24">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027289399.1">
        <property type="nucleotide sequence ID" value="XM_027433598.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K1K8"/>
    <dbReference type="GeneID" id="100759244"/>
    <dbReference type="KEGG" id="cge:100759244"/>
    <dbReference type="CTD" id="11043"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19837">
        <property type="entry name" value="Bbox1_MID2_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19823">
        <property type="entry name" value="Bbox2_MID2_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16754">
        <property type="entry name" value="RING-HC_MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13739">
        <property type="entry name" value="SPRY_PRY_TRIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase Midline-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000014">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.40:FF:000002">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047064">
        <property type="entry name" value="MID2_Bbox1_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047063">
        <property type="entry name" value="MID2_Bbox2_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033491">
        <property type="entry name" value="MID2_HC-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040859">
        <property type="entry name" value="Midline-1_COS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035752">
        <property type="entry name" value="SPRY/PRY_TRIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF12">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MID2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18568">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="19">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="21">
        <location>
            <begin position="340"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="20">
        <location>
            <begin position="516"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027289399.1"/>
        </source>
    </evidence>
    <sequence length="735" mass="83172" checksum="D58B63CA4FD5BF6C" modified="2023-06-28" version="1">MGESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPIESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVSDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLHSARNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAIGIAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMIMSGLPAPDFIDYPEQQECNCRPKESPYVSGMKACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K212</accession>
    <name>A0A9J7K212_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Usp26</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="RefSeq" id="XP_003506154.1">
        <property type="nucleotide sequence ID" value="XM_003506106.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287910.1">
        <property type="nucleotide sequence ID" value="XM_027432109.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K212"/>
    <dbReference type="GeneID" id="100763595"/>
    <dbReference type="KEGG" id="cge:100763595"/>
    <dbReference type="CTD" id="83844"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13312">
        <property type="entry name" value="PH_USP37_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.180:FF:000001">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.180">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 26/29/37, pleckstrin homology-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032069">
        <property type="entry name" value="USP37-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038093">
        <property type="entry name" value="USP37-like_PH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF918">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16674">
        <property type="entry name" value="UCH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="285"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027287910.1"/>
        </source>
    </evidence>
    <sequence length="842" mass="95588" checksum="537996DD4C8B0A33" modified="2023-06-28" version="1">MDPILIHAQVQMWSAKAGMSKTKSVCIESTVGKREVKLLLYFSTGKIKALQLNNNIKSVILRTYGDNQNYLHLTFKNNDFLFVEKLNTTDARQLKRFLDKVYQKNLRASKRNDEETSGGPSTSTEELGGSSSLEVHSEAGSKCLESAKESEVPLPSSSPATLSSMELFGKQLIKRKRSLPDSEKKGKENIPKDSSRECEAKSVVPVHDDKGKERDLGEAEMSKPGFGFSFETNYSEESDSDIHNLHDLIRKFFSPFLLEPHCVQKGVEWHECMKTLLLYPEKAWQGLPNVGNTCYINVVLQSLCSVPLFVNDLFNQGFPWIKPPTDDFNMRLMQLLVLKDIYNTKTRENLLISITKALPELADAFIADTQNDAHEFLSLCLVQLKETVQKLTVLWQSESESGGNSLLRRIFAGHAIVNKIPVCPVANNFEFELLRSIFCKGCGLAVFNKEQSSYLSINIPQGLKGQNLSIQSSFDLFFKAEELEHRCERCMHNRSIALHKFGSLPRVIILHLKRYSFKSQVMKKDEQHIIISKYLKLSFHCNRNTKLPQPLSQNAHVKDLDLLKPLQELGSEILEFSFNSLRASRFKDFTTGDTRSDNESEAQNVKIVSKVLSGKGQQEDQRYGDTANVIGSELTNETGNLKKHKKVDLLRKLDSGRISEATEESDIRIPERSPKYQQAQKCSEERRDKQTSGEAVAQKHPKPRSREQIESTRKPAEAHTQNGKLKSQGSLDSSRNPGNKDGLGKKRKSKVKVSDKEENAYRLFNIISHIGSSPQGGHYINDAFDFRKQDWFTYSDPQVTSTQEDLVCKARLSTGYVFFYMHNEIFEELLARETRSRKMSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4M2</accession>
    <name>A0A9J7K4M2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 171 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100756343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035295714.1">
        <property type="nucleotide sequence ID" value="XM_035439823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756343"/>
    <dbReference type="KEGG" id="cge:100756343"/>
    <dbReference type="OrthoDB" id="287623at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038820">
        <property type="entry name" value="CCDC171"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47899">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47899:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035295714.1"/>
        </source>
    </evidence>
    <sequence length="1333" mass="153879" checksum="A1E97F99B3536389" modified="2023-06-28" version="1">MSLNTSSNATTGDTQRLKNVSLDAKQMLKNEMESDITADLRKKLHRAKKEKLEMTTKHNAELSSYESQIARLRSEVEKGEALRQRLEYDLAVVRKESGMGRRMVEERLDEALRTQEKLCAQNLELQEKASEIEKTFQTSQEKWKEECRRFEHDLEERDNIIQNCNREYESLMQEKNKLQKTLQEALEKRQQEKNEMESHVRETALEEFRLQAEQWEAERRELQLIVQEQDSAVQNMQKKVEQLEAEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKINAQESFTKLNLLEREYFSKNKKVNEEIEEQKKVITDLSKRLQYNEKSFSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSAQWTSGIHKDKDKLPSFSVVLETLRRTLTDYQNKLEDASNELSNINDAKEKTSNELDSTKQKIESHVKRIKELQDKLTEVHKEVSHLRTKCADREALIGTLKVELQNVLHCWEKEKARAAQCESELQNLSQAFHKDSEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKMSHLEYICKNKSDTMRELQQTQEDTLSKVAEQIKAQESCWHKQKKELEFQYSELLLEVQRRAQKFQEIAEKNMEKLNRIENSHEQLVLENSHFKSALAKTQREQTCLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNGLELFKLEIRTLAQALAAVDEKKQEEAKPKKKAFKGLIRVFRKGAIAILAANRLKILGQSCASLFTWIESCKEGIGMLVCTGEPKDKHKFPKHQREQLRCVQALTWFTSSDLLAAIISSMTELQEVISKTDPNSRICGHLLIGATKSSFAKLMDKISLAMESIPLHSSRSITYVEKDSLVQRLARGLHKVNTLALKYGLRSHMPIMKSTASLQKQIFGFTQRLHAAEVERRSLRLEVTEYKRTLNEMKKELDKSQSLQMQLSEFKHSKLITHEKFESACEELNNALLREQQAQMLLNEQAQQLQELNYRLEVHSCEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRTVENMLHKVRDQISLSRTAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASARISTLEKEMTSHRNHIETLKSELHTACLRENESLQSTGSRDHSNLSIPSRAALPGDTVVDFLPIQAELDTTYRFLKETFITTAPHSLMSSQSSPVVPASVKRPSQIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K8I5</accession>
    <name>A0A9J7K8I5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Vomeronasal type-2 receptor 116-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113835672</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300050.1">
        <property type="nucleotide sequence ID" value="XM_035444159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K8I5"/>
    <dbReference type="GeneID" id="113835672"/>
    <dbReference type="KEGG" id="cge:113835672"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000125">
        <property type="entry name" value="Vomeronasal 2, receptor 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF545">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 118-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="885"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="659"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035300050.1"/>
        </source>
    </evidence>
    <sequence length="932" mass="106173" checksum="49139C1D172D1CA0" modified="2023-06-28" version="1">MIDEMCSNNWNPTTYMNADIILGAFIPIYITQDLQDQFLIPFKKKPNLFDAMIGQGFKSSNIPNLLRVDDDNTLTVLIILPLLFRGKWKNYQYLLTLYFAIEEINKDAHLLPNVTLGFHLYNAFHSHRRTLEGLLMWLCDRSEIIPNYKCKTQHKALGIIAGIRPEFSAAIGTLLELYKIPQVTYGIFYSVLSDKDTFPSVYQISPQEKALTQGVILLLLHFGWKWVGIIVADDLKGKEFLSDMTAELASKDICVAFTEKIPTYMKLELLFGGGLVNLSQHTKVNVHVFYGDIDDVLFFYILNEIRSNRKKMWIMAKPHFVYLQSVFYKWIGLMSFFEGSFSFSKKRNIPGFKHFIQALTPSQYPGDIYFHKFWLDNFHCSPSPLLCGVQELCPLNISLKNKQEIQVVMITSEPSVSIWNAVYAVAHALHEMLLSKTKIDSHKDINQDRLLPWQVSLPHRERRHWELILLVGTSLSSNTQHTFMFLRIIPLANHSCLHAKYVEYIHELHPFLRKIQFTNAAGDQICFDEKENPMEKYDIQNFVGYTNHDSFVVKVGEFVSKSPQDKGLFINEVLIKWPSNFNQNPQSVCTQSCGPGFWKLTEEGRPACCFSCVFCPERHISNQTDQQECIPCPIQQYPNPERNNCLQKSMTFLSLEDSLGLALVCAALCFSVSTAVVLGIFLKHQDSPIVKANNQTLSFILLISLLLCFMCTFLFIGQPSTASCILQQITFALVFTLVLSTVLAKTITVVLAFRAVKLGRTMRRLFVSGIYNSVIPICFLMQLILLGVWMGTSPPYIQADAHSEHSYIIILCNKGSVTAFYCVLAYLGILALGSFTVAFLARNLPDTFNESKFLTFSMLVFCSVWVTFLPVYHSTKNKAMVAVEVFSILASSAGLLGCIFIPKCYIILLRPDKNSLKCFKNKTKYIQNRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K8Q1</accession>
    <name>A0A9J7K8Q1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Opioid-binding protein/cell adhesion molecule isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Opcml</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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            <strain evidence="15">17A/GY</strain>
        </source>
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</entry>
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        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">17A/GY</strain>
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    <reference evidence="5" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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        </source>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043114">
        <property type="term" value="P:regulation of vascular permeability"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PV-1"/>
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        <property type="entry name" value="PLASMALEMMA VESICLE-ASSOCIATED PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21687:SF5">
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            <end position="48"/>
        </location>
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            <begin position="430"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035307347.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G3GR60</accession>
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        <alternativeName>
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        <alternativeName>
            <fullName evidence="11">TBP-associated factor 3</fullName>
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        <alternativeName>
            <fullName evidence="12">Transcription initiation factor TFIID 140 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Taf3</name>
        <name evidence="17" type="ORF">I79_000003</name>
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    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
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    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="21">17A/GY</strain>
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        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="8">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF3 forms the TFIID-A module together with TAF5 and TBP. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="9">Belongs to the TAF3 family.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3GXA6</accession>
    <name>G3GXA6_CRIGR</name>
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            <fullName evidence="2">Dysferlin-interacting protein 1</fullName>
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        <submittedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 27</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1, regulatory subunit 27</fullName>
        </submittedName>
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        <name evidence="3 6" type="primary">Ppp1r27</name>
        <name evidence="2" type="ORF">I79_002396</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH000058">
        <property type="protein sequence ID" value="EGW06255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003496940.1">
        <property type="nucleotide sequence ID" value="XM_003496892.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281203.1">
        <property type="nucleotide sequence ID" value="XM_027425402.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GXA6"/>
    <dbReference type="STRING" id="10029.G3GXA6"/>
    <dbReference type="PaxDb" id="10029-XP_007634118.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021618.1">
        <property type="protein sequence ID" value="ENSCGRP00001017374.1"/>
        <property type="gene ID" value="ENSCGRG00001017436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766770"/>
    <dbReference type="KEGG" id="cge:100766770"/>
    <dbReference type="CTD" id="116729"/>
    <dbReference type="eggNOG" id="KOG0505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159603"/>
    <dbReference type="OMA" id="QRDATND"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053080">
        <property type="entry name" value="PP1_regulatory_subunit_27"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW06255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027281203.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17247" checksum="76B7CE6A9AD1539B" modified="2011-11-16" version="1">MPSRTARYARYSPRQRRRRLLADRSVRFPNDVLFLDHIRQGDLEQVGRFIRARKVSLDTIHPSGLAALHEAVLSGNLECVKLLVKHGADIQQRDETGWTPLHMACSDGYPDIARYLISLGADRDATNDDGDLPSDLIDPDLPGLAELFRGTSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYH3</accession>
    <name>G3GYH3_CRIGR</name>
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        <recommendedName>
            <fullName evidence="9">Synaptotagmin-13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Synaptotagmin XIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Syt13</name>
        <name evidence="13" type="ORF">I79_002851</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in transport vesicle docking to the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with NRXN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000067">
        <property type="protein sequence ID" value="EGW03913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497327.1">
        <property type="nucleotide sequence ID" value="XM_003497279.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278248.1">
        <property type="nucleotide sequence ID" value="XM_027422447.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYH3"/>
    <dbReference type="STRING" id="10029.G3GYH3"/>
    <dbReference type="PaxDb" id="10029-XP_007630944.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022049.1">
        <property type="protein sequence ID" value="ENSCGRP00001017805.1"/>
        <property type="gene ID" value="ENSCGRG00001017740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773481"/>
    <dbReference type="KEGG" id="cge:100773481"/>
    <dbReference type="CTD" id="57586"/>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160226"/>
    <dbReference type="OMA" id="DEEGQSC"/>
    <dbReference type="OrthoDB" id="9997431at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000145">
        <property type="entry name" value="Synaptotagmin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028692">
        <property type="entry name" value="Syt13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF250">
        <property type="entry name" value="SYNAPTOTAGMIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="158"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="287"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW03913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027278248.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46790" checksum="BA6AAC3335316C6D" modified="2011-11-16" version="1">MVLSVPVIALGATLGTATSILALCGVTCLCRHMHPKKGLLPRDREPDPEKAKPGVLPSAQQFNVKKSTEPVQPRPLLKFPDIYGPRPAVTAPEVINYADYTLGTTEESAAPASPQAQSDSRLKRQVTEELFILPQNGVVEDVCVMETWNPEKAASWNQAPKLHFRLDYDQKKAELFVTSLEAVTSDHEGGCDCYIQGSVTIKTGSVEAQTALKKRQLHTTWEEGLALPLGEDELPTATLTLTLRTCDRFSRHSVVGELRLGLDGASVPLGAAQWGDLKTTAKEPSAGTGEVLLSISYLPAANRLLVVLIKAKNLHSNQSKELLGKDVSVKVTLKHQAQKLKKKQTKRAKHKINPVWNEMIMFELPDDLLRASSVELEVLGQGEEGPSCELGHCSLGLHASGSERSHWEEMLKNPRRQIAMWHQLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>G3H8V1</accession>
    <name>G3H8V1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Matrix metalloproteinase-9</fullName>
            <ecNumber evidence="4">3.4.24.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">92 kDa gelatinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">92 kDa type IV collagenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Gelatinase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32 35 36" type="primary">Mmp9</name>
        <name evidence="31" type="ORF">I79_006812</name>
    </gene>
    <organism evidence="31 33">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35 36" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="35 36">17A/GY</strain>
            <tissue evidence="35 36">Liver</tissue>
        </source>
    </reference>
    <reference evidence="32" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of gelatin types I and V and collagen types IV and V.</text>
            <dbReference type="EC" id="3.4.24.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="25">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="25">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Exists as monomer or homodimer; disulfide-linked. Also exists as heterodimer with LCN2. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.35" evidence="4"/>
    <dbReference type="EMBL" id="JH000219">
        <property type="protein sequence ID" value="EGV97682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639490.1">
        <property type="nucleotide sequence ID" value="XM_007641300.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639491.1">
        <property type="nucleotide sequence ID" value="XM_007641301.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279236.1">
        <property type="nucleotide sequence ID" value="XM_027423435.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279237.1">
        <property type="nucleotide sequence ID" value="XM_027423436.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H8V1"/>
    <dbReference type="SMR" id="G3H8V1"/>
    <dbReference type="STRING" id="10029.G3H8V1"/>
    <dbReference type="MEROPS" id="M10.004"/>
    <dbReference type="GlyGen" id="G3H8V1">
        <property type="glycosylation" value="2 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007608539.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018948.1">
        <property type="protein sequence ID" value="ENSCGRP00001014710.1"/>
        <property type="gene ID" value="ENSCGRG00001015519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770707"/>
    <dbReference type="KEGG" id="cge:100770707"/>
    <dbReference type="CTD" id="4318"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157415"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071492">
        <property type="term" value="P:cellular response to UV-A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904063">
        <property type="term" value="P:negative regulation of cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000697">
        <property type="term" value="P:negative regulation of epithelial cell differentiation involved in kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051549">
        <property type="term" value="P:positive regulation of keratinocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090200">
        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904707">
        <property type="term" value="P:positive regulation of vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904645">
        <property type="term" value="P:response to amyloid-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000010">
        <property type="entry name" value="72 kDa type IV collagenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000011">
        <property type="entry name" value="Matrix metalloproteinase-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
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    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
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    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
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        <property type="entry name" value="M10A_MMP"/>
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    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF30">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
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    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
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        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
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    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
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        <property type="entry name" value="CYSTEINE_SWITCH"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="3"/>
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    <dbReference type="PROSITE" id="PS00024">
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 25" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0177">Collagen degradation</keyword>
    <keyword evidence="18 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 35 36" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 29" id="KW-0732">Signal</keyword>
    <keyword evidence="13 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732120" description="Matrix metalloproteinase-9" evidence="29">
        <location>
            <begin position="20"/>
            <end position="710"/>
        </location>
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    <feature type="domain" description="Fibronectin type-II" evidence="30">
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            <begin position="226"/>
            <end position="274"/>
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    <feature type="domain" description="Fibronectin type-II" evidence="30">
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            <begin position="284"/>
            <end position="332"/>
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    <feature type="domain" description="Fibronectin type-II" evidence="30">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="27">
        <location>
            <begin position="521"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="27">
        <location>
            <begin position="567"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="27">
        <location>
            <begin position="661"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="439"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="25">
        <location>
            <position position="100"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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        <location>
            <position position="132"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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            <position position="166"/>
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        <location>
            <position position="176"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="178"/>
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        <ligand>
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            <position position="183"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EGV97682.1"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014710.1"/>
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    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="RefSeq" id="XP_027279236.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_027279237.1"/>
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    </evidence>
    <sequence length="710" mass="78894" checksum="520A54C0AFF5AD66" modified="2011-11-16" version="1">MRPWPSLVLALLVLGCSSAAPHQRQPTVVVFPRDLRTNNLTDTQLAQEYLYRYGYTRVAEMQGEKLSLRPALLLLQKQLSLPQTGELDSKTLEAIRAPRCGVPDLGKFQTFEGDLKWHHHNITYWIQNYSEDLPRDVIDDAFARAFAVWSAVTPLTFTRVYGLEADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDEELWSLGKGVVVPTYFGNANGAPCHFPFTFEGRSYLACTTDGRTDGAPWCSTTADYDTDRKFGFCPSETLYTEHGNGDGKPCVFPFIFEGRSYSACTTEGRSDGYRWCATTANYDQDKLYGFCPTRADATVVGGNSAGELCVFPFVFLGKEYSTCTSEGRRDGRLWCATTSSFDTDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFLEGSPLHEDDVRGIQHLYGPGPKPDPGLPATTTTAPQPTAPPTMCPTVPPTAYPTKSPQAGPTGPPAADPTGPPTAGPSEAITVSLSPADNACNVDIFDAIAEIQGSLYFFKDGRYWKFLNRRGSRLQGPFLIARTWPALPAKLDSAFEDPQSKKIFFFSGRKVWVYTGQSVLGPRRLDKLGLGSEVTQISGLLPRGGGKALLLSRERVWRFDLKTQRVDPQSVTRLDRMFPGVPWNSHDIFQYQDKAYFCQDRFYWRVSFRDEVNQVDQVGYVTYDFLQCPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3HN30</accession>
    <name>G3HN30_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 9">60S ribosomal protein L36a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">LOC100758569</name>
        <name evidence="5" type="ORF">I79_012161</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
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                <person name="Koh W."/>
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                <person name="Wang J."/>
                <person name="Gui Y."/>
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                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        </source>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
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    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
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        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000543">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027433235.2"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="476"/>
        </location>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027289036.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3HRD1</accession>
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        <recommendedName>
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        <lineage>
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    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CHO K1 cell line</strain>
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    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <location evidence="14">Coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH000634">
        <property type="protein sequence ID" value="EGV98704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506169.1">
        <property type="nucleotide sequence ID" value="XM_003506121.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246448.1">
        <property type="nucleotide sequence ID" value="XM_027390647.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HRD1"/>
    <dbReference type="STRING" id="10029.G3HRD1"/>
    <dbReference type="GlyGen" id="G3HRD1">
        <property type="glycosylation" value="4 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007609306.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010467.1">
        <property type="protein sequence ID" value="ENSCGRP00001006642.1"/>
        <property type="gene ID" value="ENSCGRG00001009012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768541"/>
    <dbReference type="KEGG" id="cge:100768541"/>
    <dbReference type="CTD" id="26020"/>
    <dbReference type="eggNOG" id="KOG1215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPADRCN"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000039">
        <property type="entry name" value="LDL receptor related protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000091">
        <property type="entry name" value="Low-density lipoprotein receptor (Ldl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000050">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000055">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF17">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="22 26" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 22 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732245" description="Low-density lipoprotein receptor-related protein 10" evidence="20">
        <location>
            <begin position="20"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="21">
        <location>
            <begin position="195"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="567"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV98704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027246448.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="76709" checksum="824D6940A048157C" modified="2011-11-16" version="1">MLPALPLLLLLLLLGGALARPDRVTFPNPACESPPAVLLEVQGTLQRPLGRDSRSSPANCTWVILGSKEQTVTVRFQKLHLACGSEHLLLRSPLQPPVSLCEAPASPLQLPGGNATITYSYAGARAPMGQGFLLSYSQDWLLCLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGCSSDPFPNLNPAPVPTPPCNLTLEDFYGVFSSPGYSHLASVSHPQSCLWLLDPHDGRRLAVRFTALDLGYGDAVHVYDGAGPPDTPRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSSGRGFNATYHVRGYCLPWDRPCGLGSGLGAGENLGERCYSEAQRCDGSWDCADGTDEEGCPGCPPGHYPCGAAGTPGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDCSYALPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGHSGGRRRQRGRSVRRLVRRLRRWGLLPRTNTPARTPETRSQVTASAAPSEALDDSTGQSCEGGAVGGQDGEQAPPLPVKPPIPTPSTLPALATVSEPPGPLPSVPLEPSLLSGVVQVLRGRLLPSLWPPGPTWTPAGHHTTVLAPEDEDDVLLMPLAEPEVWVVEAEDEPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3HWW6</accession>
    <name>G3HWW6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">XPA-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Xab2</name>
        <name evidence="23" type="ORF">I79_015479</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA. Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000841">
        <property type="protein sequence ID" value="EGW00203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003507792.1">
        <property type="nucleotide sequence ID" value="XM_003507744.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271587.1">
        <property type="nucleotide sequence ID" value="XM_027415786.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HWW6"/>
    <dbReference type="STRING" id="10029.G3HWW6"/>
    <dbReference type="PaxDb" id="10029-XP_007633490.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005053.1">
        <property type="protein sequence ID" value="ENSCGRP00001003493.1"/>
        <property type="gene ID" value="ENSCGRG00001004232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767687"/>
    <dbReference type="KEGG" id="cge:100767687"/>
    <dbReference type="CTD" id="56949"/>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075140"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001824">
        <property type="term" value="P:blastocyst development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000411">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000519">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001071">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="18" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="22">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="20">
        <location>
            <begin position="181"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="21">
        <location>
            <begin position="387"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="808"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGW00203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027271587.1"/>
        </source>
    </evidence>
    <sequence length="855" mass="100009" checksum="36929ECD8C875FCA" modified="2011-11-16" version="1">MVVMARVPRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAVRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALKLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFIARYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYDRATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIREMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPPRAQNKIFFVRSDASREELAELAQQANPEEIQLGEEEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3HZ73</accession>
    <name>G3HZ73_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nesprin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">KASH domain-containing protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nuclear envelope spectrin repeat protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22 23 24" type="primary">Syne3</name>
        <name evidence="18" type="ORF">I79_016368</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Lee K.H."/>
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                <consortium name="RefSeq"/>
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        <text evidence="11">As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.</text>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
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                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
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                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001089">
        <property type="protein sequence ID" value="EGW13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003509246.1">
        <property type="nucleotide sequence ID" value="XM_003509198.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242285.1">
        <property type="nucleotide sequence ID" value="XM_027386484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I1P8"/>
    <dbReference type="STRING" id="10029.G3I1P8"/>
    <dbReference type="PaxDb" id="10029-XP_007612276.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014603.1">
        <property type="protein sequence ID" value="ENSCGRP00001010382.1"/>
        <property type="gene ID" value="ENSCGRG00001012285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751879"/>
    <dbReference type="KEGG" id="cge:100751879"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163232"/>
    <dbReference type="OMA" id="EHKAGMQ"/>
    <dbReference type="OrthoDB" id="9445499at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15913">
        <property type="entry name" value="7tmA_OR11G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050939">
        <property type="entry name" value="Olfactory_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242:SF363">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="45"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027242285.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35020" checksum="8CBF8997AEA70034" modified="2011-11-16" version="1">MKILSKPSNSSTITGFILLGFSCPREGQILLFMLFFIVYLLTLMGNASIICAVRWDQKLHTPMYLLLANFSFLEIWYVTSTVPNMLANFLSDTKVISFSGCFLQFYFFFSLGSTECFFLAVMAFDRYLAICRPLHYPSLMTGRLCNILVISCWVLGFLWFPVPIIIISQMSFCGSRIIDHFLCDPGPLLALSCVRNSLIELTSSTLSSLLLFIPFFFIMGSYTLVMRAVLRVPSAAGRRKAFSTCGSHLAVVSLFYGSVMVMYVSPTSEHSAGIQKLVTLFYSVVTPLINPVIYSLRNKDMKHAMKKLLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3I4X7</accession>
    <name>G3I4X7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">N-lysine methyltransferase KMT5A</fullName>
            <ecNumber evidence="3">2.1.1.361</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">H4-K20-HMTase KMT5A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Histone-lysine N-methyltransferase KMT5A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Lysine-specific methylase 5A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">PR/SET domain-containing protein 07</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">SET domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30 31" type="primary">Kmt5a</name>
        <name evidence="27" type="ORF">I79_018518</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30 31" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30 31">17A/GY</strain>
            <tissue evidence="30 31">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60344"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.361"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.361" evidence="3"/>
    <dbReference type="EMBL" id="JH001273">
        <property type="protein sequence ID" value="EGW14948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269721.1">
        <property type="nucleotide sequence ID" value="XM_027413920.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269722.1">
        <property type="nucleotide sequence ID" value="XM_027413921.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I4X7"/>
    <dbReference type="STRING" id="10029.G3I4X7"/>
    <dbReference type="PaxDb" id="10029-XP_007623156.1"/>
    <dbReference type="GeneID" id="100774411"/>
    <dbReference type="CTD" id="387893"/>
    <dbReference type="eggNOG" id="KOG1085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I4X7"/>
    <dbReference type="OMA" id="NIFTCQS"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140944">
        <property type="term" value="F:histone H4K20 monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043516">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="SET_SETD8"/>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KMT5A"/>
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        <property type="entry name" value="KMT5A-like"/>
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        <property type="entry name" value="KMT5A-like_SET"/>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
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    </dbReference>
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        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
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    </dbReference>
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        <property type="entry name" value="Histone_H4-K20_mtfrase"/>
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    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 27" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="159"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="52"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
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            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="99"/>
            <end position="115"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022618"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048985"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00074863"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00080706"/>
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    <evidence type="ECO:0000256" key="22">
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    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EGW14948.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027269721.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027269722.1"/>
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    <sequence length="295" mass="33213" checksum="898A3C9F9CD2A94B" modified="2011-11-16" version="1">MSPNKCSGMRSPLQEENSVAHHEVKCQGKPLAGIYKKREEKRNGGSTIRSSVKSDEQKIKDARRGPLAPFPNQKSEAAEPPKTPPQSCDPTNTVVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3I6N8</accession>
    <name>G3I6N8_CRIGR</name>
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        <recommendedName>
            <fullName evidence="3">Neuropeptide Y receptor type 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">NPY-Y5 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 25" type="primary">Npy5r</name>
        <name evidence="20" type="ORF">H671_1g3479</name>
        <name evidence="19" type="ORF">I79_019165</name>
    </gene>
    <organism evidence="19 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001384">
        <property type="protein sequence ID" value="EGW11766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE666659">
        <property type="protein sequence ID" value="ERE87850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510824.1">
        <property type="nucleotide sequence ID" value="XM_003510776.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244661.1">
        <property type="nucleotide sequence ID" value="XM_027388860.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I6N8"/>
    <dbReference type="STRING" id="10029.G3I6N8"/>
    <dbReference type="PaxDb" id="10029-XP_007613212.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002136.1">
        <property type="protein sequence ID" value="ENSCGRP00001001800.1"/>
        <property type="gene ID" value="ENSCGRG00001001699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756867"/>
    <dbReference type="KEGG" id="cge:100756867"/>
    <dbReference type="CTD" id="4889"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161766"/>
    <dbReference type="OMA" id="RHHQDTH"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001602">
        <property type="term" value="F:pancreatic polypeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001601">
        <property type="term" value="F:peptide YY receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:cardiac left ventricle morphogenesis"/>
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        <property type="term" value="P:synaptic signaling via neuropeptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="7tmA_NPY5R"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="NPY5_rcpt"/>
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        <property type="entry name" value="NPY_rcpt"/>
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        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
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    </dbReference>
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        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR TYPE 5"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11 19 25" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="63"/>
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    <evidence type="ECO:0000313" key="25">
        <source>
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    <sequence length="466" mass="52681" checksum="211D4DE42F9BAD04" modified="2011-11-16" version="1">MDFELEEHVNKTIVAENNTAATRNAAYPVWDDYRSTENNTAAARNAAFPVWDDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPSTLTSVLLDQWMFGKAMCHVMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSGNQANPQSRQKWTYSFIRKHRRRYSKKTACVLPAPAGPSKEIHPTVPEKLGSVRSQFSSSSKVIPGVPTCFEVKPEGNSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
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        <name evidence="13 16 17 18 19" type="primary">Zbed4</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16 17 18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16 17 18">17A/GY</strain>
            <tissue evidence="16 17 18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH001879">
        <property type="protein sequence ID" value="EGW09354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003512430.5"/>
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        <property type="nucleotide sequence ID" value="XM_007652921.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651112.1">
        <property type="nucleotide sequence ID" value="XM_007652922.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651113.1">
        <property type="nucleotide sequence ID" value="XM_007652923.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252015.1">
        <property type="nucleotide sequence ID" value="XM_027396214.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252018.1">
        <property type="nucleotide sequence ID" value="XM_027396217.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296702.1">
        <property type="nucleotide sequence ID" value="XM_035440811.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296703.1">
        <property type="nucleotide sequence ID" value="XM_035440812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IC19"/>
    <dbReference type="STRING" id="10029.G3IC19"/>
    <dbReference type="PaxDb" id="10029-XP_007651111.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011730.1">
        <property type="protein sequence ID" value="ENSCGRP00001007669.1"/>
        <property type="gene ID" value="ENSCGRG00001010059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770580"/>
    <dbReference type="KEGG" id="cge:100770580"/>
    <dbReference type="CTD" id="9889"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161365"/>
    <dbReference type="OMA" id="NEMSVEC"/>
    <dbReference type="OrthoDB" id="10057873at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF4">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="285"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="457"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="558"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGW09354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027252015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027252018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035296702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035296703.1"/>
        </source>
    </evidence>
    <sequence length="1170" mass="130563" checksum="488DCC20A1187453" modified="2011-11-16" version="1">MEDKQETCPKGDSDFVPDKVNFKVEEEDDDQIPCHSLERVDFKSEPEDMRQTDSGDEQAELRAASCACQPPGKFLPAESEDDYGTLFSQYSSTLYNVAMEAVTQSLLSGRHISSRKKSPAWKHFFISPRDSTKAICTYCMKEFSRGKNEKDLSTSCLMRHVRRAHPTKLIQENGSLSVGSSFPSPSLLLPPQPADVGDLNTVLSPVRLVQKMAPKIPSPDQIMEESVTVVCSEEVSSDVSLTEKYSREEALAGSSPNFSMLHYDDTSESMAERNLSLPKSTSGSRRRSAVWKHFYLSPLDSSKAVCVHCMNEFSRGKNGKDLGTSCLIRHMWRAHRSIVLQENGGSTGIPPLYPMPPTLLPALLPPEGDLNSASLSPGKQVKECPSASSSPDRLPEDLSSHTNPGDVSREDVSMLSSSDDLGEASVVSSPEKQPADIASPRFESGTVFQQNKKVMRRLKSEVWHHFSLAPMDSLKAVCRYCSCVISRGKKGDVGTSCLMRHLYRRHPEVVGNQKDFLGASLANSPYATLASAESSSKLTDLPAVVRKNHKGVFPGNSKKTSKLWNHFSICSADSTKVVCLHCGRTISRGKKPTNLGTSCLLRHLQRFHGHVLKNDVSEATLPHSSGIRRPLGMELSGASSFRDSTEKLYDSHPVAKKITSLIAEMIALDLQPYSLVDNIGFNRLLEYLKPQYSLPSPSYFSRTAIPGMYDNVKQIIMSHLKEAESGVVHFTSGIWMSSQTREYLTLTAHWVTFASAVRPHCEDHHCSALLDVSQIDCDYSGNSIQKQLECWWEAWVTSIGLQIGITVTDNPSIGKMLSEGEHSSVQCFSHTVNLIVSEAIKSQRMVQNLLSIARKLCERVHRSPRAREKLAELQKEYELPQHQLIQDVPSKWSTSFHMLERLIEQKRAVNEVSIECNFRELISCDQWEVMQSVCHVLRPFDAASREMSAHMSTLSQVIPMIHILSRKVEMLFGETMGIDTMLKSLKEAMASRLSATLHDPRYIFATLLDPRYKASLFTEEEAEQYRQDLIRELEILNSTSEDTATSNGCDSGSPLKDTGTGESLWSLVAPIKRDKREKLPEAMVLAYLEEEVLEHSCDPLTYWNLKRSSWPGLSTLAVRFLGCPPSTVPSEKLFSTPMEAGSFGQPRLAMEHFEKLIFLKVNLPLICFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3ICV7</accession>
    <name>G3ICV7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS35 endosomal protein-sorting factor-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Vps35l</name>
        <name evidence="8" type="ORF">I79_021511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001966">
        <property type="protein sequence ID" value="EGW09415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512749.4">
        <property type="nucleotide sequence ID" value="XM_003512701.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265970.2">
        <property type="nucleotide sequence ID" value="XM_027410169.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ICV7"/>
    <dbReference type="STRING" id="10029.G3ICV7"/>
    <dbReference type="PaxDb" id="10029-XP_007632837.1"/>
    <dbReference type="GeneID" id="100774713"/>
    <dbReference type="KEGG" id="cge:100774713"/>
    <dbReference type="CTD" id="57020"/>
    <dbReference type="eggNOG" id="KOG3682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3ICV7"/>
    <dbReference type="OMA" id="RVEVCKN"/>
    <dbReference type="OrthoDB" id="1734063at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW09415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027265970.2"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113725" checksum="1DB1E0CD72F51736" modified="2011-11-16" version="1">MTQARIFRAETALHNHGGRGGAELPGHGKRGGPPRTSGHVTEKMAVFPWHSRNRNYKAELASCRLETVPLECGDYHPLKPITVTESKTKKVNRKGSTSSTSSSSSSSVVDPLSSVLDGTDPLSMFAATSDPAASGTVTDSSRKKRDKDDSSFVGPDFEPWANKRGEILARYTTTEKLSINLFMGSEKGKAGAMTSAMSEKVRTRLEELDDFEEGSQKELLNLTQQDYVSRIEELNQSLKDAWASDQKVKALKIVIQCSKLLSDTSVIQFYPSKFVLITDILDTFGKLVYERIYSMCADSRSALPDHFSPENVNDTAKETCLNWFFKIASIRELIPRFYVEASILKCNKFLSKTGISECLPRLTCMIRGIGDPLVSVYARAYLCRVGMEVAPHLKESLNKNFFDFLLTFKQIHGDTVQNQLVAQGVELLSYLPLYSPAMGWIFQCVSYHAPEALLTEMMERCKKLGNNALLLNSVMSAFRAEFVATRSMDFIGMIKECDESGFPKHLLFRSLGLNLALADPPENDRLQILNEAWKVITKLKNPQDYINCAEVWVEYTCRHFTKREVNTVLADVIKHMTPDRAFEDSYPQLQSIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMEAFIKHQQEPTKDPVILNALMHICKTMHDSVNALTLEDEKRMLAHLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAYCFITIPSLVGIFTRLNLYLHSGQVALANQCLSQADAFFKAAIGLIPEVPKTISIDGKLRPSEPFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDDKIRIYTSVLHLLSAMSQDTYLYHIDKVDSNDSLYGGDSKFLAENSKLCEAVMAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLDYIKKRSKQPDMNHLTELALRLPLQTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3IE34</accession>
    <name>G3IE34_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100762388</name>
        <name evidence="13" type="ORF">I79_021976</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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        </citation>
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            <strain evidence="16">17A/GY</strain>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502RF9W">
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        <property type="component" value="Unplaced"/>
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    </dbReference>
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        <property type="entry name" value="OLFACTORYR"/>
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    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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                <person name="Borth N."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
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    <reference evidence="3" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="Ensembl" id="ENSCGRT00001017051.1">
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    <dbReference type="GeneTree" id="ENSGT00390000004746"/>
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    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
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    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047658">
        <property type="term" value="F:alpha-amino-acid esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000181">
        <property type="entry name" value="valacyclovir hydrolase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331:SF2">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW15139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027265077.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32635" checksum="81AEE49989FD0D7D" modified="2011-11-16" version="1">MAPAAAHPAALRLRLLLSPLRSRIPAPQTKPAAAFGTAVTSAKVAVNGVHLHYQRTGEGEHAVLLLPGMLGSGSTDFAPQLQSLNKKRFTVVAWDPRGYGQSRPPDRDFPQDFFERDAKDAVDLMKVLQFKQVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTEEDSRIYQGIRDVSKWSEKARKPLEALYGYDYFAKTCEKWVDGINQFKHLPDGNICRHLLPLVQCPTLIVHGEKDPLVPRFHADFLHKHVKGSRLHLMPEGKHNLHLRFANEFNKLAEDFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3IF12</accession>
    <name>G3IF12_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC100761696</name>
        <name evidence="17" type="ORF">H671_4g12685</name>
        <name evidence="16" type="ORF">I79_022324</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002305">
        <property type="protein sequence ID" value="EGW06514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE675473">
        <property type="protein sequence ID" value="ERE75387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651862.1">
        <property type="nucleotide sequence ID" value="XM_007653672.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268037.1">
        <property type="nucleotide sequence ID" value="XM_027412236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IF12"/>
    <dbReference type="STRING" id="10029.G3IF12"/>
    <dbReference type="PaxDb" id="10029-XP_007623523.1"/>
    <dbReference type="GeneID" id="100761696"/>
    <dbReference type="KEGG" id="cge:100761696"/>
    <dbReference type="eggNOG" id="ENOG502RTZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9829559at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15405">
        <property type="entry name" value="7tmA_OR8B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000646">
        <property type="entry name" value="Olfactory receptor 887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:001035">
        <property type="entry name" value="Putative olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW06514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ERE75387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027268037.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35088" checksum="336A13F4DF9E4749" modified="2011-11-16" version="1">MLAENGSLVTEFVLAGLTDHPELQLPLFFLFLMIYIVTVVGNFGLVTLIGLNPHLHTPMYYFLFNLSFIDLCYSSVFSPKMLMNFICEKNTISYVGCMTQLFLFLFFVISECYMLTSMAYDRYVAICNPLLYKVTMSPQVCSVISFAAYGMGFAGASAHTGCMLRLTFCNANVINHYLCDILPLLQLSCTSTYVNEVVVLIVVGINITVPSFTILISYVFILANILNIKSTQGRAKAFSTCSSHIMAISLFFGSAAFMYLKYSSGSMEQGKISSVFYTNIGPMLNPLIYSLRNKDVKVALRKSLIKFQRKDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6RUG6</accession>
    <name>Q6RUG6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CDC6</name>
        <name evidence="22 25" type="synonym">Cdc6</name>
        <name evidence="21" type="ORF">I79_018784</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 25" key="1">
        <citation type="journal article" date="2004" name="Mol. Cell. Biol." volume="24" first="1614" last="1627">
            <title>Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.</title>
            <authorList>
                <person name="Alexandrow M.G."/>
                <person name="Hamlin J.L."/>
            </authorList>
            <dbReference type="PubMed" id="14749377"/>
            <dbReference type="DOI" id="10.1128/MCB.24.4.1614-1627.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
            <authorList>
                <person name="Becker J."/>
                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
            </authorList>
            <dbReference type="PubMed" id="21945585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14 16">Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA, ORC1, cyclin-CDK. Interacts with HUWE1. Interacts with ANKRD17. Interacts with GRWD1; origin binding of GRWD1 is dependent on CDC6. Interacts with CDT1; are mutually dependent on one another for loading MCM complexes onto chromatin. Interacts with TTC4. Interacts (via Cy motif) with CCNF; the interaction takes place during G2 and M phase. Interacts with CDH1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY491989">
        <property type="protein sequence ID" value="AAR83016.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH001313">
        <property type="protein sequence ID" value="EGW13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001231207.1">
        <property type="nucleotide sequence ID" value="NM_001244278.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649300.1">
        <property type="nucleotide sequence ID" value="XM_007651110.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649301.1">
        <property type="nucleotide sequence ID" value="XM_007651111.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6RUG6"/>
    <dbReference type="STRING" id="10029.Q6RUG6"/>
    <dbReference type="PaxDb" id="10029-NP_001231207.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029858.1">
        <property type="protein sequence ID" value="ENSCGRP00001025612.1"/>
        <property type="gene ID" value="ENSCGRG00001023158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100689243"/>
    <dbReference type="KEGG" id="cge:100689243"/>
    <dbReference type="CTD" id="990"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063498"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000265">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000058">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 20 25" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="195"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="19">
        <location>
            <begin position="466"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AAR83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGW13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="NP_001231207.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62266" checksum="340ECA9438D7001C" modified="2004-07-05" version="1">MPQTRSQAQATISFPKKKLTKTASKTSSSISKVQLKKAQAVPSAPCVDTKLLPLSPRKRLGDDNLCNTPHLSPCSPPKLGKKENGPPHSHTRKGCRLVFDDELTVKSSNQKEQDQVPQNQILSSAQEGQERKADSEQKCPPEKEPARVRLFKQEGTCYQQAKLVLNTAVPDRLPARDKEMDVIRAFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDLKKEVKGFKTIMLNCMSLRSAQAVFPAIAQEIGHEEMCRPAGKDLMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEARENCKPQLLNFPPYTRNQIATILQDRLNQVSREQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEIVEADVKSQTVLKPLSEGQSPSEAPVPKRVGLAHISQVISEVDGNRLILSQEKTQDSFPLQQKILVCSLLLLTRRLKIKEVTLGKLYEAYSSVCRKQRVAAVDQSECLSLSGLLESRGILGLKKNKESRLTKVSLKIEEKEIEHVLKGKAFIGNILADGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q80WL0</accession>
    <name>Q80WL0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4</fullName>
            <ecNumber evidence="15">2.4.3.2</ecNumber>
            <ecNumber evidence="16">2.4.3.4</ecNumber>
            <ecNumber evidence="22">2.4.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Alpha 2,3-sialyltransferase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">N-acetyllactosaminide alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">ST3Gal IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Sialyltransferase 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35 37" type="primary">St3gal4</name>
    </gene>
    <organism evidence="34">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2003-04" db="EMBL/GenBank/DDBJ databases">
            <title>Cricetulus griseus mRNA for Gal beta-1,3/4-GlcNAc alpha-2,3-sialyltransferase St3Gal IV.</title>
            <authorList>
                <person name="Clark K.J.R."/>
                <person name="Bailey K.M."/>
                <person name="Harcum S.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="34 37" key="2">
        <citation type="journal article" date="2005" name="Biotechnol. Bioeng." volume="90" first="568" last="577">
            <title>Gene-expression profiles for five key glycosylation genes for galactose-fed CHO cells expressing recombinant IL-4/13 cytokine trap.</title>
            <authorList>
                <person name="Clark K.J."/>
                <person name="Griffiths J."/>
                <person name="Bailey K.M."/>
                <person name="Harcum S.W."/>
            </authorList>
            <dbReference type="PubMed" id="15818560"/>
            <dbReference type="DOI" id="10.1002/bit.20439"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
            <authorList>
                <person name="Becker J."/>
                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
            </authorList>
            <dbReference type="PubMed" id="21945585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="36" key="4">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="36" key="5">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="37" key="6">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="7">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:139596"/>
            <dbReference type="EC" id="2.4.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21617"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:136588"/>
            <dbReference type="ChEBI" id="CHEBI:136589"/>
            <dbReference type="EC" id="2.4.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:52381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52316"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:136545"/>
            <dbReference type="EC" id="2.4.3.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:52317"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27938"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:47561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:77709"/>
            <dbReference type="ChEBI" id="CHEBI:78445"/>
            <dbReference type="EC" id="2.4.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:18022"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87789"/>
            <dbReference type="ChEBI" id="CHEBI:87791"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:47589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:90376"/>
            <dbReference type="ChEBI" id="CHEBI:90390"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:65433"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17006"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:58665"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.4.3.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:18914"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.2" evidence="15"/>
    <dbReference type="EC" id="2.4.3.4" evidence="16"/>
    <dbReference type="EC" id="2.4.3.6" evidence="22"/>
    <dbReference type="EMBL" id="AY266675">
        <property type="protein sequence ID" value="AAP22942.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233628.1">
        <property type="nucleotide sequence ID" value="NM_001246699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q80WL0"/>
    <dbReference type="SMR" id="Q80WL0"/>
    <dbReference type="CAZy" id="GT29">
        <property type="family name" value="Glycosyltransferase Family 29"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001007317.1">
        <property type="protein sequence ID" value="ENSCGRP00001004831.1"/>
        <property type="gene ID" value="ENSCGRG00001006222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100689440"/>
    <dbReference type="KEGG" id="cge:100689440"/>
    <dbReference type="CTD" id="6484"/>
    <dbReference type="OMA" id="WEPCYLL"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="BRENDA" id="2.4.99.9">
        <property type="organism ID" value="1309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047288">
        <property type="term" value="F:beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003836">
        <property type="term" value="F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008118">
        <property type="term" value="F:N-acetyllactosaminide alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009101">
        <property type="term" value="P:glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030194">
        <property type="term" value="P:positive regulation of blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903238">
        <property type="term" value="P:positive regulation of leukocyte tethering or rolling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23982">
        <property type="entry name" value="GT29_ST3GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000005">
        <property type="entry name" value="ST3 beta-galactoside alpha-2,3-sialyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF57">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 34" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 34" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 33" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="32">
        <location>
            <begin position="121"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00072813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00075868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00076295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00076532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00081234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00082801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="AAP22942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="NP_001233628.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38326" checksum="B3B397B1360C4A3D" modified="2003-06-01" version="1">MTSKSRCKFLAMLALVFVVVMVWYSISREDRYFELFYFPISEKKEPCFQGEAERQASKIFGNHSREQPIFLQLKDYFWVKTPSTYELPFGTKGSEDLLLRVLAITSYSIPESIQSLQCRRCVVVGNGHRLRNSSLGSIINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAAEKLLSLPIQQSRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPEAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRMLEMGAVKNLTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HTV3</accession>
    <name>A0A061HTV3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein phosphatase 1 regulatory subunit 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Ppp1r14a</name>
        <name evidence="9" type="ORF">H671_21475</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="KE689200">
        <property type="protein sequence ID" value="ERE50157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286368.1">
        <property type="nucleotide sequence ID" value="XM_027430567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HTV3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007977.1">
        <property type="protein sequence ID" value="ENSCGRP00001005217.1"/>
        <property type="gene ID" value="ENSCGRG00001006805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763398"/>
    <dbReference type="KEGG" id="cge:100763398"/>
    <dbReference type="CTD" id="94274"/>
    <dbReference type="GeneTree" id="ENSGT00950000182985"/>
    <dbReference type="OrthoDB" id="8193882at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.220:FF:000002">
        <property type="entry name" value="protein phosphatase 1 regulatory subunit 14A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="entry name" value="CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008025">
        <property type="entry name" value="CPI-17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05361">
        <property type="entry name" value="PP1_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 7" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ERE50157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027286368.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16884" checksum="220BF502DFB38933" modified="2014-09-03" version="1">MAAQRLGKRVLSKLQSPSRARGPGGSPSGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGRESDMPDEVNIDELLELDSEEERSRKIQGLLESCRNPTEDFIQELLAKLRGLHKQPGFPQPSRADDRSLSPHQDRAHTAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IBV1</accession>
    <name>A0A061IBV1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BBSome complex member BBS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Bbs1</name>
        <name evidence="20" type="ORF">H671_3g10130</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with the C-terminus of RAB3IP. Interacts with CCDC28B and ALDOB. Interacts with PKD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE673007">
        <property type="protein sequence ID" value="ERE78739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648980.3">
        <property type="nucleotide sequence ID" value="XM_007650790.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264455.1">
        <property type="nucleotide sequence ID" value="XM_027408654.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IBV1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017366.1">
        <property type="protein sequence ID" value="ENSCGRP00001013129.1"/>
        <property type="gene ID" value="ENSCGRG00001014350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767595"/>
    <dbReference type="KEGG" id="cge:100767595"/>
    <dbReference type="CTD" id="582"/>
    <dbReference type="OrthoDB" id="10259809at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030534">
        <property type="term" value="P:adult behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048854">
        <property type="term" value="P:brain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021766">
        <property type="term" value="P:hippocampus development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:hormone metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:neural precursor cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060296">
        <property type="term" value="P:regulation of cilium beat frequency involved in ciliary motility"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:striatum development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0021591">
        <property type="term" value="P:ventricular system development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Bardet-Biedl syndrome 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028784">
        <property type="entry name" value="BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032728">
        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056419">
        <property type="entry name" value="GAE_BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14779">
        <property type="entry name" value="BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23304">
        <property type="entry name" value="GAE_BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="domain" description="Bardet-Biedl syndrome 1 N-terminal" evidence="18">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Bardet-Biedl syndrome 1 protein GAE" evidence="19">
        <location>
            <begin position="486"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013129.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027264455.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="65353" checksum="39DD8CBE04C4FFC6" modified="2014-09-03" version="1">MAATSSADSDSGRTESSEANSKWLDAHYDPMANIHTFSPCLALADLHGDGEYKLVVGDLGPDGQQPRLKVLKGPTVLTESPLPALPASAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLEDIREKAEVPLSVQSLRFLQLELSEMEAFVNQHKAKVIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLTAACRNGSIYILRRDSKHPKYCIELSAQPVGLVRVYKTLVVGSTQESLHGFTHKGKKLWTVQMPAAILTMNLLEQRSRGLQAVMAALANGEVRIYRDKALLNVIHAPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGTGETGPPLAQTTKLNVPRKTRLYVDQTLREREAGTAMHRTFQTDLYLLRLRAARAYVQALESSLSPMSSTAREPLKLHAVVQGLGPTFKLTLHLQNTSTARPALGLQVCFLYNEALYALPRAFFKVPLLVPGLSYPLETFVESLNSKGISDMIKVLVLREGQSAPLLSAHINMPVSEGMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IEY3</accession>
    <name>A0A061IEY3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100750846</name>
        <name evidence="14" type="ORF">H671_3g9828</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE672598">
        <property type="protein sequence ID" value="ERE79152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263813.1">
        <property type="nucleotide sequence ID" value="XM_027408012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IEY3"/>
    <dbReference type="GeneID" id="100750846"/>
    <dbReference type="KEGG" id="cge:100750846"/>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF430">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE79152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027263813.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36177" checksum="DACA49C516EE26F8" modified="2014-09-03" version="1">MAMSSNHTNLRDIWYTMVGIPGLEYAHIWLSIPICSMYIVALAGNTLLIFLIFTDHSLHEPMYLFLSILALADIILSTVTTPKVLAIFWFRAGGISFASCVSQMFFLHFMFVTESAILLAMAFDRYVAICFPLRYTTILTPLVIARMGIASVTRSFLICFPLVFLVYRLTYCGRNIIHHSYCEHMGIARLACDNIKVNIYYGMTVPLFSIGLDIVLIIISYILILHSVFRIPSRDARLKALGTCGSHVCVILLFYTPSLFTFFAHRFGGHSIPRHMHILFANLYVVVPPTLNPIIYGVKTKQIQDRIFQMFSFHKACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7GNI5</accession>
    <name>A0A3L7GNI5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Pfn1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with VASP. Interacts with HTT. Interacts with SH3BGRL. Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Interacts with ACTMAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282708.1">
        <property type="nucleotide sequence ID" value="XM_027426907.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7GNI5"/>
    <dbReference type="SMR" id="A0A3L7GNI5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015758.1">
        <property type="protein sequence ID" value="ENSCGRP00001011526.1"/>
        <property type="gene ID" value="ENSCGRG00001013146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753478"/>
    <dbReference type="KEGG" id="cge:100753478"/>
    <dbReference type="CTD" id="5216"/>
    <dbReference type="GeneTree" id="ENSGT00940000153664"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000008">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005454">
        <property type="entry name" value="Profilin1/2/3_vertebrate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13936">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13936:SF14">
        <property type="entry name" value="PROFILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01639">
        <property type="entry name" value="PROFILINMAML"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027282708.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14957" checksum="1DC8B60D545FF70E" modified="2019-02-13" version="1">MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSITPAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVTVTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HXX7</accession>
    <name>A0A3L7HXX7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Talin rod domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mesoderm development candidate 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Tlnrd1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May homodimerize. Interacts with F-actin.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263363.1">
        <property type="nucleotide sequence ID" value="XM_027407562.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HXX7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011569.1">
        <property type="protein sequence ID" value="ENSCGRP00001007523.1"/>
        <property type="gene ID" value="ENSCGRG00001009930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760136"/>
    <dbReference type="KEGG" id="cge:100760136"/>
    <dbReference type="CTD" id="59274"/>
    <dbReference type="GeneTree" id="ENSGT00910000144335"/>
    <dbReference type="OrthoDB" id="10009851at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000018">
        <property type="entry name" value="Mesoderm development candidate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054082">
        <property type="entry name" value="Talin_IBS2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042799">
        <property type="entry name" value="TLNRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47133">
        <property type="entry name" value="TALIN ROD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47133:SF1">
        <property type="entry name" value="TALIN ROD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21896">
        <property type="entry name" value="Talin_IBS2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Talin IBS2B" evidence="7">
        <location>
            <begin position="149"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027263363.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="37726" checksum="70DA7BE7130AC7FE" modified="2019-02-13" version="1">MASGSAGKPTGEAASPAPGSAVGGASSQPRKRLVSICDHCKGKMQLVADLLLLSSEARPVLFEGPASPGAGAESFEQCRDTIIARTKGLSILTHDVQSQLNMGRFGEAGDSLVELGDLVVSLTECSAHAAYLAAVATPGAQPAQPGLVDRYRVTRCRHEVEQGCAVLRATPLADMTPQLLLEVSQGLSRNLKFLTDACALASDKSRDRFSREQFKLGVKCMSTSASALLACVREVKAAPSELARSRCALFSGPLVQAVSALVGFATEPQFLGRAAAVSAEGKAVQTAILGGAMSVVSACVLLTQCLRDLAQHPDGGAKMSDHRERLRNSACAVSEGCTLLSQALRERSSPRTLPPVNSNSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HYV5</accession>
    <name>A0A3L7HYV5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PH and SEC7 domain-containing protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Pleckstrin and Sec7 domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Psd</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027262935.1">
        <property type="nucleotide sequence ID" value="XM_027407134.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027296306.1">
        <property type="nucleotide sequence ID" value="XM_027440505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HYV5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000482.1">
        <property type="protein sequence ID" value="ENSCGRP00001000458.1"/>
        <property type="gene ID" value="ENSCGRG00001000373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774898"/>
    <dbReference type="KEGG" id="cge:100774898"/>
    <dbReference type="CTD" id="5662"/>
    <dbReference type="OMA" id="IPNELCI"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099092">
        <property type="term" value="C:postsynaptic density, intracellular component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13295">
        <property type="entry name" value="PH_EFA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000004">
        <property type="entry name" value="PH and SEC7 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000054">
        <property type="entry name" value="PH and SEC7 domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF334">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="9">
        <location>
            <begin position="542"/>
            <end position="707"/>
        </location>
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            <begin position="757"/>
            <end position="870"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
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        </location>
    </feature>
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        </location>
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            <end position="1011"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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            <dbReference type="PROSITE" id="PS50190"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000458.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027262935.1"/>
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    <sequence length="1025" mass="109837" checksum="98178F0FBEBEE66F" modified="2019-02-13" version="1">MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLIRRVAGPGPRGRDLGRVTAPCTPLRGPPSPRMAPSRWGPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPASGGLSRSWDLGGVSPSRPSPVLGPGCNRKLRLEASTSDPLPAGGGFALPGSRDPSRGPLVPPQIGVDGLYSSLPNGLGGTPEHLAMHFRGPSDTGFLTQGDTWSSTREVSSHAQRIARAKWEFFYGSLDAPSSGAKPPEQVLPSHGVGSKQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEQEEAADSAIESQPSSEGPAGTGRPPASRPSPCPGPPSSLGSGNEDDEAGGDEDVEDEVFEASEGPRPGDHMPLSGPLKSPVPFLPGTSPSVDGPDSFSCVFEAILESHRAKGTSYSSLASLEALASPGPTKSPFFTFEMPPQPPVPRPDPPAPAPLAPLQPDSGTSSAADGLWTQRREVEESDAGAKLVPRRELPSPSHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTFGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRVSGGSGSSSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKTFHGILKGMILYLQKEEYQPGKALSEAELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKMKAMASELREHRAAHLGKKARGKEADEQRQKEAYLEFEKSRYGTYAALLRVKMKAASEELDAIEAALAQAGSTEDGCPPPHSSPSLQPNPTSQTRAQRSGSEARAGAGSTRPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I7F4</accession>
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        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <source>
            <strain evidence="6">17A/GY</strain>
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        </source>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027255515.1">
        <property type="nucleotide sequence ID" value="XM_027399714.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I8J4"/>
    <dbReference type="SMR" id="A0A3L7I8J4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032413.1">
        <property type="protein sequence ID" value="ENSCGRP00001028165.1"/>
        <property type="gene ID" value="ENSCGRG00001024962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759021"/>
    <dbReference type="KEGG" id="cge:100759021"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905344">
        <property type="term" value="P:prostaglandin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF13">
        <property type="entry name" value="ACYL-PROTEIN THIOESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001028165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027255515.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="24778" checksum="17163A12B237354E" modified="2019-02-13" version="1">MCGNAMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEVGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LA78</accession>
    <name>A0A8C2LA78_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor IIIB 90 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">B-related factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Brf1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1. Interacts with MAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272472.1">
        <property type="nucleotide sequence ID" value="XM_027416671.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LA78"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000287.1">
        <property type="protein sequence ID" value="ENSCGRP00001000263.1"/>
        <property type="gene ID" value="ENSCGRG00001000222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753600"/>
    <dbReference type="KEGG" id="cge:100753600"/>
    <dbReference type="CTD" id="2972"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000012">
        <property type="entry name" value="Putative transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.650:FF:000001">
        <property type="entry name" value="transcription factor IIIB 90 kDa subunit isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="18">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="544"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="617"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027272472.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="73746" checksum="6FE186C23BFD791F" modified="2022-01-19" version="1">MTGRVCRGCGGTDIELDAARGDAVCTGCGSVLEDNIIVSEVQFVENSGGGSSAVGQFVSLDGAGKTPTLGGGFHVNLGKESRAQTLQNGRRHIHHLGSQLQLNQHCLDTAFNFFKMAVSKHLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFGEKNHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTLRKRLTEFEDTPTSQLTIDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISSYQDAIEIELENSRPKAKGALANLSKDGSGEDSTPSPFCEEDTEDEELEAAASHMNKDFYRELLGDGGGSEGTGDPDGGSRPLALESLLGPLPTAASLGISDSIRECISSPSGDPKDTSGDGELDLSGIDDLEIDRYILNESEARVKAELWMRENAEYLREQKEKEARIAKEKELGIYKEHKPKKSCKRREPILASTAGEAIEKMLEQKKISSKINYSVLRDLNSKGGSSPPREDSQPPEQASTKKLSRRKRAASRSSADPGTSIGKRLRPLVSTHPAKKAAVGEALLLSSPTLGAEPIKPSAVLVESGPVSYHPDEDADEEDAEEEDGEPCVSALQMMGGNDYGCDGDEDDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LAI4</accession>
    <name>A0A8C2LAI4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transforming growth factor, beta receptor associated protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10 11 12">Transforming growth factor-beta receptor-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10 11 12" type="primary">Tgfbrap1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10 11 12">17A/GY</strain>
            <tissue evidence="10 11 12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003499564.1">
        <property type="nucleotide sequence ID" value="XM_003499516.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242538.1">
        <property type="nucleotide sequence ID" value="XM_027386737.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242539.1">
        <property type="nucleotide sequence ID" value="XM_027386738.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242540.1">
        <property type="nucleotide sequence ID" value="XM_027386739.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LAI4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001423.1">
        <property type="protein sequence ID" value="ENSCGRP00001001356.1"/>
        <property type="gene ID" value="ENSCGRG00001001074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762020"/>
    <dbReference type="KEGG" id="cge:100762020"/>
    <dbReference type="CTD" id="9392"/>
    <dbReference type="GeneTree" id="ENSGT00530000063596"/>
    <dbReference type="OMA" id="MFVTSEG"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005160">
        <property type="term" value="F:transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="564"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027242538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027242539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027242540.1"/>
        </source>
    </evidence>
    <sequence length="860" mass="97258" checksum="B1D53C8FB3C6E18B" modified="2022-01-19" version="1">MMNIKAFTLVSAVERELLTGDKEHISIECVECCGRNLYVGTSDCFIYHFLLEEKALPTGTASFIATKQLHRHLGFKKPVNELCAASALNRLLVLCDNSITLVNMLNLEPVPSGARIKGATTFAVNENPVNGDPFCVEVCIISVKRRTVQMFLVYEDRVQIVKEVSTPEQPLAVAVDGYFLCLALTTQYIILNYSTGLSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELFRSSQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRFLMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIVNGDIQDSTRSDLYEYIVDFLTYCLDKELVWTHADWLLQKSEEIGVQVFTKRPLDEQQQTSFNPDDIIRCLKKYPKALVKYLEHLVIDRRLQKEEYHTHLATLYLEEVLRQRVATGSKDMEATETQVKLRRLLQKSDSYHVHLLKEKIQGAGLPMESAILHGKLGEHEKALHILVHEMGDFSAAEDYCLWGSEGQDAACRQRLFHTLLAMYLRAGPSAHELTVAAVDLLNHHSREFDATQVLQLLPDTWSVQLLCPFLTGAMRDSIHARRTTQVALGLAKSENLIYTYDKMKLKGSAVQLSEKKLCQLCQNPFSEPVFVRYPNGGLVHTHCAASRHTTPSSPSPGTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LE20</accession>
    <name>A0A8C2LE20_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Gastric inhibitory polypeptide receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glucose-dependent insulinotropic polypeptide receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">LOC113837293</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">May form homodimers and heterodimers with GLP1R.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304991.1">
        <property type="nucleotide sequence ID" value="XM_035449100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LE20"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000563.1">
        <property type="protein sequence ID" value="ENSCGRP00001000539.1"/>
        <property type="gene ID" value="ENSCGRG00001000434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113837293"/>
    <dbReference type="KEGG" id="cge:113837293"/>
    <dbReference type="GeneTree" id="ENSGT00940000161988"/>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016519">
        <property type="term" value="F:gastric inhibitory peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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    <sequence length="459" mass="52403" checksum="ABC29BDBB46C0000" modified="2022-01-19" version="1">MPLWLLLLCLWGLPLQKAETDSEGQTTGELYQRWERYGRECEETLEAADAPSGVVCNGSFDMYVCWDYTAANTTARASCPWYLPWYRHVAAGYVFRQCGSDGQWGPWRDHTQCENPEKNGAFQDQRLILERLQVVYTVGYSLSLGTLLLALLILSLFRRLHCTRSYIHMNLFSSFMLRAAAILTRDRLLPTLGPYPGDRTPTPWNQALAACRAAQIVTQYCVGANYTWLLVEGVHLHHLLVIVGGSDKGHFRCYLLLGWGAPALFVIPWVIVRYLLENTQCWERNEVKAIWWIIRTPILVTILINFFIFIRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQAEGTLRFAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIRRSWRHLILHLSLRDERPRPHMELGPPAMPSCSAPREVPIGSTLPSGSLHGPGDEVLESYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LQG6</accession>
    <name>A0A8C2LQG6_CRIGR</name>
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        </submittedName>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_035438643.1"/>
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        <property type="gene ID" value="ENSCGRG00001006536.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47077">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="67"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035294534.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51393" checksum="8F0AD8815AE479D9" modified="2022-01-19" version="1">MSENQNWWHQPEIGTAQHSNTTKNTYEFMGRREEQVLINRRDITDKKDAWDIEEFITTMYVKQLLRHPAFQMLLALLLVTNAITIALRTNSYLGQKHYELFSIIDDIVLTILICEVLLGWINGFWIFWKDGWNILNFLIVFMLFLGLFIKQLDVVAVTYPLRALRLVHVCMAVEPLANIIRVILQSVPDLANVVALILFFMLVFSVFGVTLFGAFVPKHFQNMGVALYTLFICITQDGWLDIYSDFQMENREIAMEVGGAIYFATFITIGAFIGLNLFVVVVTTNLEQMMKIGEQGQQRQITFTEIGADEDDFVDDLPLVHCTEARKETSGHPQEPLVGGPLCNLTEKTCDNFCLVLEAIQENLREYKQIREELDKIVEEVRSIRYNQEQEKELLLRHASKSLSSQTDSSLDIREVATQQDLISALVSREKVHDSSTNMLSKHKFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LR96</accession>
    <name>A0A8C2LR96_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tigger transposable element derived 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Tigd5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tigger transposable element derived protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027259665.1">
        <property type="nucleotide sequence ID" value="XM_027403864.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LR96"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012623.1">
        <property type="protein sequence ID" value="ENSCGRP00001008494.1"/>
        <property type="gene ID" value="ENSCGRG00001010766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755601"/>
    <dbReference type="KEGG" id="cge:100755601"/>
    <dbReference type="CTD" id="84948"/>
    <dbReference type="GeneTree" id="ENSGT00940000154420"/>
    <dbReference type="OrthoDB" id="5919228at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007379">
        <property type="term" value="P:segment specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000293">
        <property type="entry name" value="Tigger transposable element-derived protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF56">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="8">
        <location>
            <begin position="56"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027259665.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="70486" checksum="ACDBAF8BDB9D426A" modified="2022-01-19" version="1">MYPTSPPAGPALHPVPHRARLPSPRRLAEPPLSPAPGQGPTARPPPIAPGPRPRVAVKMTFRKAYSIKDKLQAIERVKGGERQASVCRDFGVPGGTLRGWLKDEPKLRWFLDQLGGEVGTQRKKMRLANEEEIDRAVYSWFLTLRQHGVPLSGPVIQAQAEAFARQIYGPECTFKASHGWFWRWQKRHGISSQRIYGEAEPPVAGPAPVKEEPAQTPGAVLLPDRALTILPHSEGGYDDEQIYNANVTGLYWRLLPEQAATQGAGNSSGPSGCTQRWPGDRVTVLLAANLTGSHKLKPLVIGRLPDPPSLRHHNQDKFPASYRYSPDAWLSRPLLRGWFFEEFVPGVKRFLRRSCLQQKAVLLVAHPPCPSWGARMPALEESEETPRQCQPDLFGSPEELQTPDGAVRVLFLSKGNSRAHIPAPLEHGVVAAFKHLYKRELLRLAVSCASGSPLDFMRSFMLKDMLYLAGLSWDLVQAGSIERCWLLGLRAAFEPGQLPAHQVEEAAEHSRVLSDLTHLATLVYKRLAPEEVAEWLHLDDDGGLPEGCREEVVPATPPSPASLPSSMGAGEEEEEATEQGAMLVPTAGEAVWGLETALRWLESQDPREVAPLRLVQLRSLITMARRLGGIGPSPAAPHDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LYY8</accession>
    <name>A0A8C2LYY8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Gk</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="RefSeq" id="XP_007646699.1">
        <property type="nucleotide sequence ID" value="XM_007648509.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288539.1">
        <property type="nucleotide sequence ID" value="XM_027432738.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LYY8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015488.1">
        <property type="protein sequence ID" value="ENSCGRP00001011259.1"/>
        <property type="gene ID" value="ENSCGRG00001012921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753140"/>
    <dbReference type="KEGG" id="cge:100753140"/>
    <dbReference type="CTD" id="2710"/>
    <dbReference type="GeneTree" id="ENSGT01000000214434"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019217">
        <property type="term" value="P:regulation of fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000043">
        <property type="entry name" value="glycerol kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000033">
        <property type="entry name" value="glycerol kinase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF56">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="9 15 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="16">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="17">
        <location>
            <begin position="282"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027288539.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="61313" checksum="DDE71CAFC5888F59" modified="2022-01-19" version="1">MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQSTVENLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQKAVEENRALFGTIDSWLIWSLTGGIHGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMEILPNVRSSSEIYGLMKISHSLKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M2F0</accession>
    <name>A0A8C2M2F0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4 7">Late cornified envelope protein 3D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">LOC100757432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307593.1">
        <property type="nucleotide sequence ID" value="XM_035451702.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314778.1">
        <property type="nucleotide sequence ID" value="XM_035458887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M2F0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013996.1">
        <property type="protein sequence ID" value="ENSCGRP00001009777.1"/>
        <property type="gene ID" value="ENSCGRG00001011825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757432"/>
    <dbReference type="KEGG" id="cge:100757432"/>
    <dbReference type="OMA" id="GCCLGHH"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LCE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14672">
        <property type="entry name" value="LCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0417">Keratinization</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035307593.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="9771" checksum="B43128B902F011B1" modified="2022-01-19" version="1">MSCQQNQKQCQPPPKCPSPKCPPKSTAQCLPAASSCCATSSGGCSVPSSEGGCFLSHHRRRSHRCRHRSSSRSCDRGSGQQSGGSGCGHSSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M819</accession>
    <name>A0A8C2M819_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphodiesterase</fullName>
            <ecNumber evidence="16">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Pde4a</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="16">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_027267295.1">
        <property type="nucleotide sequence ID" value="XM_027411494.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309959.1">
        <property type="nucleotide sequence ID" value="XM_035454068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M819"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017498.1">
        <property type="protein sequence ID" value="ENSCGRP00001013261.1"/>
        <property type="gene ID" value="ENSCGRG00001014442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759696"/>
    <dbReference type="CTD" id="5141"/>
    <dbReference type="GeneTree" id="ENSGT00940000159788"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MC70</accession>
    <name>A0A8C2MC70_CRIGR</name>
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    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027401718.2"/>
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        <property type="gene ID" value="ENSCGRG00001015736.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
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        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline phosphatase-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678834" evidence="7">
        <location>
            <begin position="36"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027257519.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59365" checksum="DD868C959605E092" modified="2022-01-19" version="1">MGEPKGCTGRQARGPGLQLLLLLSLLLRQPPPGLASGAARPPHVVFVLADDLGWNDVGFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHTGLQHLLIRVCQPSCVPLDEKLLPQLLKEAGYATHMVGKWHLGMCQKECLPTRRGFDTYFGYLLGSENYYTHEVCALIEPLNVTRCALDFRDGEEPATKYNNTYSTHIFSQRATTLIANHPPEKPLFLYLALQSVHDPLQVPEEYMKPYDFIQDKHRRIYAGMVSLMDEAVGNVTAALKSHGLWNNTVFVFSTDNGGQTLSGGNNWPLRGRKWTLWEGGIRGVGFVASPLLKQKGVKSRELIHISDWLPTLVNLAGGSTYGTKPLDGFDVWRTISEGTPSPRVELLHNIDQDFFDSSPCPGKSMAEAKNDSFPLKYSAFNTSIHAGIRYKNWKLLTGHPGCGFWFPPPSQSNISEIRSLDSSSKTLWLFDINQDPEERHDLSEKHPHIVLKLLSRLQYYHEHSVPSYFPPMDPRCDPKDTGVWSPWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MDV2</accession>
    <name>A0A8C2MDV2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6 7 8">Transmembrane protein 164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6 7 8" type="primary">Tmem164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6 7 8">17A/GY</strain>
            <tissue evidence="6 7 8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027289388.1">
        <property type="nucleotide sequence ID" value="XM_027433587.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289389.1">
        <property type="nucleotide sequence ID" value="XM_027433588.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289390.1">
        <property type="nucleotide sequence ID" value="XM_027433589.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315920.1">
        <property type="nucleotide sequence ID" value="XM_035460029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MDV2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020577.1">
        <property type="protein sequence ID" value="ENSCGRP00001016333.1"/>
        <property type="gene ID" value="ENSCGRG00001016700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759923"/>
    <dbReference type="KEGG" id="cge:100759923"/>
    <dbReference type="CTD" id="84187"/>
    <dbReference type="GeneTree" id="ENSGT00390000007430"/>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
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        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027289388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027289389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027289390.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33444" checksum="43E74BD90FC4D5FF" modified="2022-01-19" version="1">MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQTEDGRGGRGRQPQQVTQRPEEGKESLSKNLLLVALCLIFGVEVGFKFATKTVIYLLNPCHLVTMMHIFLLACPPCPGAIVIFKLQMHMLNGALLALLFPVVNTRLLPFELEIYYIQHVMLYVVPIYLLWKGGAYTPEPLSSFRWALLSTGLMFFYHFSVLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MEQ0</accession>
    <name>A0A8C2MEQ0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor ETV6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ETS translocation variant 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">ETS-related protein Tel1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Etv6</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027285668.1">
        <property type="nucleotide sequence ID" value="XM_027429867.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MEQ0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021573.1">
        <property type="protein sequence ID" value="ENSCGRP00001017329.1"/>
        <property type="gene ID" value="ENSCGRG00001017397.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771873"/>
    <dbReference type="KEGG" id="cge:100771873"/>
    <dbReference type="CTD" id="2120"/>
    <dbReference type="GeneTree" id="ENSGT00940000159508"/>
    <dbReference type="OrthoDB" id="6408625at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071425">
        <property type="term" value="P:hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097152">
        <property type="term" value="P:mesenchymal cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007296">
        <property type="term" value="P:vitellogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08535">
        <property type="entry name" value="SAM_PNT-Tel_Yan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000030">
        <property type="entry name" value="transcription factor ETV6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000176">
        <property type="entry name" value="transcription factor ETV6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR ETV6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PNT" evidence="20">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="19">
        <location>
            <begin position="339"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="154"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027285668.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="52909" checksum="9085A09D25B6ABF0" modified="2022-01-19" version="1">MSETPAQCSIKQERVSYTPPESPVASYGSSTPLHVPVPHALRMEEDSIHLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIESNSFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTKPEVLLHQNHEEDNCVQRTSRPPAESVHHNPPTIELLHRPRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRLQQENNHQESYPLSVSPMENNHCPPSSESNPKPSSPWQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGMHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQSYQEDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MFM1</accession>
    <name>A0A8C2MFM1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Vps4b</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027273667.1">
        <property type="nucleotide sequence ID" value="XM_027417866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MFM1"/>
    <dbReference type="SMR" id="A0A8C2MFM1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021995.1">
        <property type="protein sequence ID" value="ENSCGRP00001017751.1"/>
        <property type="gene ID" value="ENSCGRG00001017700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752222"/>
    <dbReference type="KEGG" id="cge:100752222"/>
    <dbReference type="CTD" id="9525"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF72">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="17">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="166"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027273667.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49454" checksum="A53C5763034F3703" modified="2022-01-19" version="1">MASTSNNLQKAIDLASKASQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAEKLKEYLKKKEKKPQKPVKEEQSSAVDEKGNDSDGEAESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARAAMFKLHLGSTQNSLTEADFQELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRSDPNCIVNDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVSMWDMLRSLTSTKPTVNEHDLLKLKKFTEDFGQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MLA8</accession>
    <name>A0A8C2MLA8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Complement C4-A isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">C4a</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Non-enzymatic component of C3 and C5 convertases. Generated following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway), it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal. It then recruits the serine protease complement C2b to form the C3 and C5 convertases, which cleave and activate C3 and C5, respectively, the next components of the complement pathways. Complement C4b-A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while complement C4b-B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Complement C4b is composed of complement C4b-A, complement C4 beta and complement C4 gamma chains that are associated via disulfide bonds. Non-enzymatic component of the C3 convertase, also named C4bC2b, composed of the serine protease complement C2b (C2), as well as complement C4b. Non-enzymatic component of the C5 convertase, also named C4bC2bC3b, composed of the serine protease complement C2b (C2), complement C3b, as well as complement C4b.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">In absence of complement activation, circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027244586.1">
        <property type="nucleotide sequence ID" value="XM_027388785.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001024797.1">
        <property type="protein sequence ID" value="ENSCGRP00001020553.1"/>
        <property type="gene ID" value="ENSCGRG00001019658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767983"/>
    <dbReference type="KEGG" id="cge:100767983"/>
    <dbReference type="CTD" id="720"/>
    <dbReference type="GeneTree" id="ENSGT00940000155739"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00017">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02896">
        <property type="entry name" value="complement_C3_C4_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000155">
        <property type="entry name" value="complement C3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.690:FF:000002">
        <property type="entry name" value="Complement C4 isoform-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000010">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.130.20:FF:000002">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000009">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1540:FF:000001">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000803">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000004">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000007">
        <property type="entry name" value="Complement C4-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000005">
        <property type="entry name" value="complement C4-A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.20.50.160:FF:000001">
        <property type="entry name" value="Complement component 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1940:FF:000001">
        <property type="entry name" value="Complement component C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1540:FF:000006">
        <property type="entry name" value="MHC-linked complement C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.91.20">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018081">
        <property type="entry name" value="Anaphylatoxin_comp_syst"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001840">
        <property type="entry name" value="Anaphylatoxn_comp_syst_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048847">
        <property type="entry name" value="C4_MG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054587">
        <property type="entry name" value="CO4A-B_CUB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF86">
        <property type="entry name" value="COMPLEMENT C4-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01821">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21145">
        <property type="entry name" value="C4_MG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22661">
        <property type="entry name" value="CO4A-B_CUB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00004">
        <property type="entry name" value="ANAPHYLATOXN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00104">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47686">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01177">
        <property type="entry name" value="ANAPHYLATOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01178">
        <property type="entry name" value="ANAPHYLATOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="14" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0765">Sulfation</keyword>
    <keyword evidence="11" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678936" evidence="20">
        <location>
            <begin position="16"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphylatoxin-like" evidence="21">
        <location>
            <begin position="697"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="22">
        <location>
            <begin position="1586"/>
            <end position="1733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00093590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027244586.1"/>
        </source>
    </evidence>
    <sequence length="1735" mass="191853" checksum="B53B559F958671C2" modified="2022-01-19" version="1">MRLLWGLLWMFSVFALSLQKPRLLLFSPSVVNLGVPLSVGLQLQDAPPEQQVKGSVLLRNPNGGPCSPKTDFTLSSGNDFVLLNLKVPLENVRDCGLFNLRRAPHVQLVVQSPWLKNVMSKATDTQGVNLLFSARRGHIFVQTDQPIYNPGQRVRYRVFALDHKMRPSTDTLTVTVENSDGLRVRKKEVFVPTSIFQDSFIIPDISEPGTWKISGRFSDSPQSNSSTHFEVKKYVLPNFEVKITPWKPYILTVPSSLDEIQLDIQARYVYGKPVQGVAYTRFALMDEHGERTFLRGLETQTKLVEGQCQVSISKDKFQAALDKVNMGVGDLEGLHLYAAAAVIESPGGEMEEAELTSWRFVSSPFSLDLSNTKQHLVPGAPFLLQAVVREMAGSLASDVPVKVSATLSSDSKVLDFQQNTNGIGQVSISIYVPPATTELRLSVSAGSPYPAKAQLTVRAPPPRSSGFLSIEPLDHRPPRVGDTLTLNLRTVPQGVTFSHYYYMIVSRGQIVTMNREARRTLTSISVLVEHHLAPSFYVVAYYSHQGLLVANSLLINVQPGDCEGKLELNVDGAKEYRTGDNMRLQIQTDSQALVALGAVDTALYAVGGKSHRPLDMSKVFEVMNSYNLGCGPGGGDNALQVFQAAGLAFSDGDQLSQVRGGLSCPKEKKSRQKRNVNFQKAVSEKLGQYASPEARRCCQDGLTRLPMARTCAQRAARVRQQACREPFLSCCLFAEELRKNHTRSQAGLARAQEVLQEEDLIEEDRILVRSFFPENWLWKVEPVDRFKLLTPWLPDSLTTWEIHGVSLSKSKGLCVAKPIRVRVFREFHMHLRLPASVRRFEQLELRPVLYNYLNTEQTVSVHVSPVEGLCLAGGGGLAQQVTVPAGSARPVAFSVVPTAAAAVSLKVVARGLFDVGDAVSKILQIEKEGAIHREEMVYELNPLDDRARTLEIPGSSDPNIIPEGDFSSFVRVTASEPLDTLGSEGALSPGGVASLLRLPRGCAEQTMIYLAPTLTASQYLDKTEQWSKLPPETKDHAMDLIQKGHMRIQQFRKKDGSFGAWLHRDSSTWLTAFVLKILSLAQEQVGDSPEKLQQTADWLLSQQLGDGSFHDPCPVIHRGMQGGLVGNDETVALTAFVVIALHHGLAVFQDGSAQQLKSRVEASISKANDFLGQKASAGLLGAHAAAITAYALTLTQASEDLRNVAHNSLMSMAEETDENLYWGLVVGSQNNVVSPTPAPRSPSEPVPQAPALWIETTAYGLLHLLLREGKGEMADKAASWLTHQGSFAGAFRSTQDTVVTLEALAEYWIASHTAEEKVLNVTLSSLGRNGFKSHALQLNNHQVKGLEEELKFSLGSKITVKVGGNSKGTLKVLRTYNVLNLENTTCQDLQMDVTVTGYVEYTREANEDYEDYEYEMPAVDDPSAHAKPVTPLQLFEGRRNRRRREAPKVAEEQESRVQYTVCIWRNGKEGLSGMAIADITLLSGFHALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGALQEVAVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSKLLSTLCSADVCQCAEGKCPKQRRSLERGEQDKDGYRMKFACYYPRVEYGFQVKVLREDGRAAFRLFETKITRVLHFTKDAKALVGQTRNFLVRASCRLHLEPNKEYLIMGMDGVTSDLKGDPQYLLDSSSWIEEMPSERLCRSTRQRAACAQLSDFIREYSSQGCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MN40</accession>
    <name>A0A8C2MN40_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cell division cycle and apoptosis regulator protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell cycle and apoptosis regulatory protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21 22 23 24" type="primary">Ccar1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_016829888.1">
        <property type="nucleotide sequence ID" value="XM_016974399.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244037.1">
        <property type="nucleotide sequence ID" value="XM_027388236.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244038.1">
        <property type="nucleotide sequence ID" value="XM_027388237.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244039.1">
        <property type="nucleotide sequence ID" value="XM_027388238.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244040.1">
        <property type="nucleotide sequence ID" value="XM_027388239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MN40"/>
    <dbReference type="SMR" id="A0A8C2MN40"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024524.1">
        <property type="protein sequence ID" value="ENSCGRP00001020280.1"/>
        <property type="gene ID" value="ENSCGRG00001019471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767167"/>
    <dbReference type="KEGG" id="cge:100767167"/>
    <dbReference type="CTD" id="55749"/>
    <dbReference type="GeneTree" id="ENSGT00530000063672"/>
    <dbReference type="OrthoDB" id="21006at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000216">
        <property type="entry name" value="Cell division cycle and apoptosis regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000006">
        <property type="entry name" value="Cell division cycle and apoptosis regulator protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025224">
        <property type="entry name" value="CCAR1/CCAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025954">
        <property type="entry name" value="DBC1/CARP1_inactive_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045353">
        <property type="entry name" value="LAIKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025223">
        <property type="entry name" value="S1-like_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304:SF14">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14443">
        <property type="entry name" value="DBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19256">
        <property type="entry name" value="LAIKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14444">
        <property type="entry name" value="S1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01122">
        <property type="entry name" value="DBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="21 22 23" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SAP" evidence="17">
        <location>
            <begin position="636"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="285"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="602"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="673"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="796"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1034"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="832"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="856"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="890"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027244037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027244038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027244039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027244040.1"/>
        </source>
    </evidence>
    <sequence length="1150" mass="132575" checksum="8F53DE9AB2DBDDE9" modified="2022-01-19" version="1">MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQQYSQPQQALYSVQQQLQQPQQTILTQPAVALPTSLSLSTPQPAAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLGAVKGKTPQVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERDRERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAVLDPPDADHLYSAKVMLMASPSMEDLYHKSCALAEDPQELRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEETHKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKKADGEQDEEEKDDGEVKEISTPTHWSKLDPKAMKVNDLRKELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEEDEDDRKSEDDKEEEERKRQEEMERQRQERRYILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKEKKSKKDERKDKKEERDDDTDDPKPKRRKSGDDKDKKEDRDERKKEEKRKEDSKDDDETEEDNNQDEYDPMEAEDAEDEEDDREEEEMNKRDDKRDVNRYCKERPSKDKEKEKTQMVTVNRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLRESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDGEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREVKKDLGQLQENLKVSENMNLQFENQLTKTLRNLSTVMDDIHTVLKKDNIKNEDRDQKSKENGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MST6</accession>
    <name>A0A8C2MST6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger protein 271</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC118238184</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294633.1">
        <property type="nucleotide sequence ID" value="XM_035438742.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310716.1">
        <property type="nucleotide sequence ID" value="XM_035454825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MST6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027525.1">
        <property type="protein sequence ID" value="ENSCGRP00001023279.1"/>
        <property type="gene ID" value="ENSCGRG00001021560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118238184"/>
    <dbReference type="KEGG" id="cge:118238184"/>
    <dbReference type="GeneTree" id="ENSGT00940000162441"/>
    <dbReference type="OMA" id="YGQSFVW"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002437">
        <property type="term" value="P:inflammatory response to antigenic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045629">
        <property type="term" value="P:negative regulation of T-helper 2 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003583">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000136">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000824">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001534">
        <property type="entry name" value="zinc finger protein 227 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002259">
        <property type="entry name" value="zinc finger protein 271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001697">
        <property type="entry name" value="zinc finger protein 623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000431">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000953">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000862">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035294633.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="67108" checksum="59FB9C5C5D2E0709" modified="2022-01-19" version="1">MEIQFSCESQEHHLLSDGETKIKIGEPASEEEMTGNIETLAEESGSLTEDVLQNSKSKEFRESGDELNDQNLLERRQYACDECGQSFAWNTGLIRHQRTHWEKPYECDECGKAFRMSSALVLHQRIHTGEKPYPCNWCIKSFSRSSDLIKHQRVHTGEKPYKCDECGKAFSQSSDLIIHQRIHTGEKPYQCSHCRKSFSQRSDMVKHQRIHTGEKPYMCNQCNKHFSQSSDLIKHQRIHTGEKPYKCDVCGKAFSQSSDLILHQRIHTGEKPYPCAQCNKSFSQNSDLIKHRRIHTGEKPYKCSECGKAFNQSSVLILHQRIHTGEKPYPCNQCTKTFSRLSDLINHQRIHTGEKPFPCSQCSKMFSRRSDLVKHYRIHTGEKPYECDECGKTFSQSSNLILHQRIHTGEKPYPCSGCSKSFSRRSDLIKHQRIHTGEKPYTCNLCNKSFSQSSDLTKHQRIHSGEKPYHCDRCDKAFSQSSDLILHHRVHTGEKPYACSQCTRSFSQNSDLIKHQRIHTGEKPYKCNVCGRAFSQCSALTLHQRIHTGEKPYPCAQCGKNFSRRSDLTNHQRIHIGEKLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MVH2</accession>
    <name>A0A8C2MVH2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="21">LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase-like N isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">Protein tyrosine phosphatase receptor type N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">LOC100768982</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027397292.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MVH2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027933.1">
        <property type="protein sequence ID" value="ENSCGRP00001023687.1"/>
        <property type="gene ID" value="ENSCGRG00001021829.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768982"/>
    <dbReference type="KEGG" id="cge:100768982"/>
    <dbReference type="GeneTree" id="ENSGT00940000154095"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:secretory granule"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990502">
        <property type="term" value="P:dense core granule maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904692">
        <property type="term" value="P:positive regulation of type B pancreatic cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to reactive oxygen species"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14609">
        <property type="entry name" value="R-PTP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2470:FF:000001">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase-like N isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000017">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase-like N isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2470">
        <property type="entry name" value="Protein-tyrosine phosphatase receptor IA-2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021613">
        <property type="entry name" value="Receptor_IA-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038112">
        <property type="entry name" value="Receptor_IA-2_ectodomain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029403">
        <property type="entry name" value="RESP18_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF1">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11548">
        <property type="entry name" value="Receptor_IA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14948">
        <property type="entry name" value="RESP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01305">
        <property type="entry name" value="RESP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679025" evidence="15">
        <location>
            <begin position="41"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="714"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="893"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="391"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="648"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00034103"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MXU6</accession>
    <name>A0A8C2MXU6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 1 regulatory subunit 3F isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Protein phosphatase 1, regulatory subunit 3F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">Ppp1r3f</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027289035.1">
        <property type="nucleotide sequence ID" value="XM_027433234.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313471.1">
        <property type="nucleotide sequence ID" value="XM_035457580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MXU6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028945.1">
        <property type="protein sequence ID" value="ENSCGRP00001024699.1"/>
        <property type="gene ID" value="ENSCGRG00001022530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767964"/>
    <dbReference type="KEGG" id="cge:100767964"/>
    <dbReference type="CTD" id="89801"/>
    <dbReference type="GeneTree" id="ENSGT00390000013859"/>
    <dbReference type="OrthoDB" id="8942186at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF40">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="3">
        <location>
            <begin position="127"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024699.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027289035.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="84140" checksum="1E01134D96211CC4" modified="2022-01-19" version="1">MARTAPVEPPLRHPAPPSPAAGEPRASVEAAVAPRRVLFADEALGLPLAQLRRYRPWGGPGAGKMAAETGQDGGGGGADEDDDGEDGDEGEEEEEAFPDPSPLCPVPAGGGFYLVPTFSLPPALGRLERLGRVMVELEALLPPPGAVPGGSGVWVPGGRPPVVRGLVRVLNRSFEKAVHVRASHDGWASFCDHPARYVPRSLPGAGVGGTGAGDPLLDPGLGLGPGQMSASSPDDGGRTDRFAFQLPFAEGAGDGARLDFVVRYETPEGTFWANNHGRNYTVLLRIAPAPTPTDAEGLIQQQQLQQLEPQPECQGPVEAEARQLKSCMKPVRRRPLEEELRMKSTDDNALSEHPDVHGSLGPLVAPTPLRPWPQMTLRVSEATVTNNPWEEGDIPRSNPPVAFTEVLQTPAIRILPSTRGLRGPPKDQASGPDASDRATGPFLEPSQHQVEATWESGVGRKAPTVGAMTDEPARGLEIVSGLEELLGEDTIDQELEQLYLSHLSRLRAVASGAGGEGSTDGGMSPSHPLGILTDRDLILKWPGPERALNSALAEEITLHYARLGCGVELIKDTEDPDDEGEGEEGLSITPSSPEGDTPKESPPEIVSGARSVVAMGDVWLPWAEGSGCDSPVVVGTQGQFTENPEKGMDKDINSLHMNRPIDGVARSPGEAGTEAPMEVPTEWAGSLIPISDKEPPAPVLPEQSPSLLSPPGTEVCLSSVANPHVTSQDEEGGSLNLESPERSPMPAAPAECVCGLSPQLRGPLTQTLGVLAGLIVVPVALNSGMSLLVLVLCLSLAWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N5J5</accession>
    <name>A0A8C2N5J5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">EH domain-containing protein 4 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">EH-domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Ehd4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027277936.1">
        <property type="nucleotide sequence ID" value="XM_027422135.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N5J5"/>
    <dbReference type="SMR" id="A0A8C2N5J5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032269.1">
        <property type="protein sequence ID" value="ENSCGRP00001028021.1"/>
        <property type="gene ID" value="ENSCGRG00001024863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771177"/>
    <dbReference type="KEGG" id="cge:100771177"/>
    <dbReference type="CTD" id="30844"/>
    <dbReference type="GeneTree" id="ENSGT00940000158601"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002042">
        <property type="term" value="P:cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF57">
        <property type="entry name" value="EH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="58"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="447"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="479"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001028021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027277936.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61433" checksum="7969393FEB8552D9" modified="2022-01-19" version="1">MFSWMGRQAGGRERSGGMDAVQTVTGGLRSLYQRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISIIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPNVFGKENKKRELIFRLPEIYVQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLSNKIASLMSLISQEEMNMPTQMVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYELPNSLPPHLVPPSHRKSLPKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QE95</accession>
    <name>A0A8C2QE95_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Arpc5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003502916.3">
        <property type="nucleotide sequence ID" value="XM_003502868.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273179.1">
        <property type="nucleotide sequence ID" value="XM_027417378.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QE95"/>
    <dbReference type="SMR" id="A0A8C2QE95"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009062.1">
        <property type="protein sequence ID" value="ENSCGRP00001005849.1"/>
        <property type="gene ID" value="ENSCGRG00001007754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766799"/>
    <dbReference type="KEGG" id="cge:100766799"/>
    <dbReference type="CTD" id="10092"/>
    <dbReference type="GeneTree" id="ENSGT00940000154654"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027273179.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16320" checksum="F050B11774EA6E66" modified="2022-01-19" version="1">MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QHW0</accession>
    <name>A0A8C2QHW0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 22">Exonuclease 1</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26 29" type="primary">Exo1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="22">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'-&gt;3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'-&gt;5' exonuclease activity and suppress the 5'-&gt;3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'-&gt;3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="RefSeq" id="XP_007638781.1">
        <property type="nucleotide sequence ID" value="XM_007640591.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274691.1">
        <property type="nucleotide sequence ID" value="XM_027418890.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QHW0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017650.1">
        <property type="protein sequence ID" value="ENSCGRP00001013413.1"/>
        <property type="gene ID" value="ENSCGRG00001014562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772338"/>
    <dbReference type="KEGG" id="cge:100772338"/>
    <dbReference type="CTD" id="9156"/>
    <dbReference type="GeneTree" id="ENSGT00510000047676"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110025">
        <property type="term" value="P:DNA strand resection involved in replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002455">
        <property type="term" value="P:humoral immune response mediated by circulating immunoglobulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016446">
        <property type="term" value="P:somatic hypermutation of immunoglobulin genes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 22" id="KW-0228">DNA excision</keyword>
    <keyword evidence="17 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14 22" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11 22 29" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="12 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="25">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="24">
        <location>
            <begin position="150"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="526"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="732"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    <evidence type="ECO:0000259" key="25">
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            <dbReference type="SMART" id="SM00485"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
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        </source>
    </evidence>
    <sequence length="890" mass="97617" checksum="6B4995E9F16BF41C" modified="2022-01-19" version="1">MLLEYSLHSLGTMGIQGLLQFIKEASEPINVKKYKGQAVAVDTYCWLHKGAISCAEKLAKGEPTDKYVGFCMKFVNMLLSHGVKPILVFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARECFTRSVNITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLLAFGCKKVILKMDQFGNGLEVDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLKLANNPDIVKVIKKIGQYLKMNITVPEDYITGFIRANNTFLYQLVFDPIQRKLVPLNAYGNDVDPETLSYAGQYVDDSEALQRALGNRDINTFEQIDDYSPDTMPVHSRSHSWNDKSCQKSPVANSIWHRNYCPRREVNGVSHAPPLTENSSTVGLKQVISTKGLNLPRKSSMVKRPRNEALSEDDLLSQYSSFTKKTKKNSCGDNAAFSSSEMSAPILDDGTAHKTDAYTPSRTRNKFAVFLRRKNEKSGAVVVPGTRSRFFCSSPDFDDFEPKKASSQPLNETAVPGKATTSLRAPDCPGTDGLGAPDCPGTDGLRAPDSPGTDGLREPDSPGTDGLGALDCPDTDGQKLVGISGTQDPSAQIPGSVTVSPDEAQSSKTSKFVDTVSPFSLGTLRSCFNWSRTLRDFSRTPSPSSSTVLQQFRRKSESPSCLPENCALTDTCHSKSEMSNAKAPPLHEVGWSTPSRESIDSLCSLNASNLSQPSSKDSDSEESDCNSKSLDNQGNQNFEQLLPPFSKTDTLARNKVPGLCRSSSTDSLSTTKIKPLVPARVSGLSKKPGSVQKRKHHDAENKPGLQIKISELWKNFGFKKDSEKLPSCKKPLSPVKDNIQLTPESEDELFNKPECARAQRAIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QIL4</accession>
    <name>A0A8C2QIL4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box and leucine-rich repeat protein 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 8 9">F-box/LRR-repeat protein 4 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7 8 9 10" type="primary">Fbxl4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7 8 9">17A/GY</strain>
            <tissue evidence="7 8 9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027259249.1">
        <property type="nucleotide sequence ID" value="XM_027403448.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259250.1">
        <property type="nucleotide sequence ID" value="XM_027403449.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259251.1">
        <property type="nucleotide sequence ID" value="XM_027403450.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295839.1">
        <property type="nucleotide sequence ID" value="XM_035439948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QIL4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019193.1">
        <property type="protein sequence ID" value="ENSCGRP00001014954.1"/>
        <property type="gene ID" value="ENSCGRG00001015697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764957"/>
    <dbReference type="KEGG" id="cge:100764957"/>
    <dbReference type="CTD" id="26235"/>
    <dbReference type="GeneTree" id="ENSGT00940000155184"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22117">
        <property type="entry name" value="F-box_FBXL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000050">
        <property type="entry name" value="F-box and leucine-rich repeat protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000628">
        <property type="entry name" value="F-box and leucine-rich repeat protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000152">
        <property type="entry name" value="F-box/LRR-repeat protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF152">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="277"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027259249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027259250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027259251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035295839.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="70102" checksum="777D64AAF8D621A7" modified="2022-01-19" version="1">MSPVFPMLTVLTMFYYMCLRRRARTATRGDMMNSHRTIVSNSRTSPHNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGIPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFRRTPSSFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERPTKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLDYYTELDAVVLHGTKDKPLLSLKTSLVDMNDLEGDDYEEKDGCGIDGLNKKFSSAALGDGPNNGYFDKLPYELIQLILNHLSLPDLCRLAQTCRLLHQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQARCALVQWLNLSWTGNRGSISVPGFSRFLNVCGSELVRLELSCSHFLNETCLEVISEMCPNLQDLNLSSCDKLPPQAFGHIAKLCSLRRLILYRTKVEQTALLSILNFCAELRHLSLGSCVMIEDYDVIASMIGAKCKNLRTLDLWRCKNITENGIAELASGCVLLEELDLGWCPTLQSSTGCFTRLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFPKVFIKKSFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QKW6</accession>
    <name>A0A8C2QKW6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Gamma-aminobutyric acid receptor subunit gamma-1 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="24">Gamma-aminobutyric acid type A receptor subunit gamma 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Gabrg1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027246636.1">
        <property type="nucleotide sequence ID" value="XM_027390835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QKW6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023468.1">
        <property type="protein sequence ID" value="ENSCGRP00001019224.1"/>
        <property type="gene ID" value="ENSCGRG00001018724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756681"/>
    <dbReference type="KEGG" id="cge:100756681"/>
    <dbReference type="CTD" id="2565"/>
    <dbReference type="GeneTree" id="ENSGT00940000160193"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19000">
        <property type="entry name" value="LGIC_ECD_GABAAR_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19054">
        <property type="entry name" value="LGIC_TM_GABAAR_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000003">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit gamma-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005438">
        <property type="entry name" value="GABBAg1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005437">
        <property type="entry name" value="GABRG-1/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01620">
        <property type="entry name" value="GABAARGAMMA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01621">
        <property type="entry name" value="GABAARGAMMA1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="27" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044520818" evidence="20">
        <location>
            <begin position="20"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="64"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="276"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="389"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR605437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027246636.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53615" checksum="65E4BE1DD2F7540B" modified="2022-01-19" version="1">MGSRKAFLFSPFLWSQTRGVRLMFLLLTLHLGNCVDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRHRKHKNRTSVSPGLHAGSTLIPMNSISLPQGEDDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7CH59</accession>
    <name>A0A9J7CH59_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Selenoprotein T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Selenot</name>
        <name evidence="14" type="synonym">Selt</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
            <authorList>
                <person name="Becker J."/>
                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
            </authorList>
            <dbReference type="PubMed" id="21945585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Selenoprotein with thioredoxin reductase-like oxidoreductase activity. Protects dopaminergic neurons against oxidative stress and cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion. Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation. In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SelWTH family. Selenoprotein T subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001243780.1">
        <property type="nucleotide sequence ID" value="NM_001256851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768242"/>
    <dbReference type="KEGG" id="cge:100768242"/>
    <dbReference type="CTD" id="51714"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000085">
        <property type="entry name" value="Selenoprotein T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0711">Selenium</keyword>
    <keyword evidence="6 12 14" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 12 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12 14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038206372" description="Selenoprotein T" evidence="12 14">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="14">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="NP_001243780.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22340" checksum="D25B6E986ADC6F0B" modified="2023-06-28" version="1" precursor="true">MRFLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSIFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EWW0</accession>
    <name>A0A9J7EWW0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Class I histocompatibility antigen, Gogo-A*0101 alpha chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113832472</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the presentation of foreign antigens to the immune system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027244481.1">
        <property type="nucleotide sequence ID" value="XM_027388680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EWW0"/>
    <dbReference type="GeneID" id="113832472"/>
    <dbReference type="KEGG" id="cge:113832472"/>
    <dbReference type="OrthoDB" id="9581542at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002486">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002476">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07698">
        <property type="entry name" value="IgC1_MHC_I_alpha3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000014">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF169">
        <property type="entry name" value="HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
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        <location>
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            <end position="175"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027244481.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26897" checksum="7466F8B5ADDAF1A7" modified="2023-06-28" version="1">MSCDVLPGSNYIHGQYEIIINGLDYIALNEDLSTWTAVGKAAEILTQQWEKIGHTKTLRPFLEGECVQRLHSHLDYGKEILLRRDTPKLHVTHKVRADGTITLRCWALDFYPTEITLTWQKDGSNQNLDMEVIETRPAGDGTFQKWAAVVVPPGEEQSYTCHVNHEGLPEPLTLRWEPPQPSVPIMPIVIGLILGAVLMGAVVTFLIRKWRNKGKKRAGPEFVSLWEYQAQLKMCPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EYI5</accession>
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    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Rodentia</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the ST7 family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF8">
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="534"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="578" mass="66180" checksum="32D6203D1DD13BE3" modified="2023-06-28" version="1">MAEAAAAGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLRINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZ30</accession>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027242588.2">
        <property type="nucleotide sequence ID" value="XM_027386787.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027434820.2"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10056949at2759"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="TreeGrafter"/>
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        <location>
            <begin position="86"/>
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            <dbReference type="Pfam" id="PF25340"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027242588.2"/>
        </source>
    </evidence>
    <sequence length="508" mass="57466" checksum="CAF0B1C60B974FCB" modified="2023-06-28" version="1">MAPCFEGREPHTLSGDVVAFGKSTDYNNVIQQEEIRNDRCVNDLQCENHSPIKTDLIGSPVSPFRRCPFWEQELANKYSCKMVVFLADEYCNYCRDILQNVRNQELEKVEELITSFWKSLQQDTVMLMSLPDVRQLFGCYDMQLFKGLEDALLPDFLEDVSIQYLKSVRLFSKRFKLWLLSALEGFPAILQISKLKEVTGFVKRLRRKTYLSNMAKTMKMVLKNSRRVGLLKSDLRAIISEGTLDISKKVLAGDSGHEEDLESHTEMKCLGCLISLLETSTDLAELLNCVSSNLQVLVFQPSKTKEEFVKLAASFQLRWNFLLTAVSKAMTLSHRDSFGAWHLFHLLLLEYVIHILESCVEEEEEEEDLGSLQDLLSDDQFLTQPDQALFHPLDTLPTSECASRSVESPQVTLKHMSQSCSSMGVSSMVLQVLGFLVDTATGNKLIQVLLEDKATESTVKLSLPVGQEALITLSNGQRFVIHISDVPQSSENTYCRKINSNMQGGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZH7</accession>
    <name>A0A9J7EZH7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Friend virus susceptibility protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC107978680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4 5 6">17A/GY</strain>
            <tissue evidence="4 5 6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027243225.1">
        <property type="nucleotide sequence ID" value="XM_027387424.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243226.1">
        <property type="nucleotide sequence ID" value="XM_027387425.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308111.1">
        <property type="nucleotide sequence ID" value="XM_035452220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EZH7"/>
    <dbReference type="GeneID" id="107978680"/>
    <dbReference type="KEGG" id="cge:107978680"/>
    <dbReference type="OrthoDB" id="9909099at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053270">
        <property type="entry name" value="Fv1_restriction_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48195">
        <property type="entry name" value="FRIEND VIRUS SUSCEPTIBILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48195:SF2">
        <property type="entry name" value="FRIEND VIRUS SUSCEPTIBILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027243225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027243226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035308111.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57034" checksum="86286DD741177F4C" modified="2023-06-28" version="1">MNLLSIWNRLFYSPALSTTEASPVRENAESPWCELYYKLKEMDAFDYPDSPIVNGSEFGNSVYETFDSLGENKENDAAGWLLLGSLGRLIKDRNELREKINQLQKMVKGNEELSDKVDQLQMQINSLEVSKCVLEENLLASSHRAQVAENQTKALVIRLAELQQKFRSQPWRVSAVKIRALVGEEWDPITWSGDVWEDPVDNENFEPSDAPEFISPDEAVPSAPPLETSPFSPLTEKINPPLSAKPAVTFSEGDASQDNTDVPRGSRPETRPKAKQASSRKVERVVRGKVHYTTKELNEFAVSFKQKSGEHVWGWVLRVWDNGGRNIKLDQTEFIDMGPLSRDSRFNMEARTVRKGVKSLLEWLTEAFIKRWPTEKELEMPDLPWLSVDEGILRLREIAMLEWIYCVQPNPPQWESPEDMPFTNPIRRKMVRGAPAHLKSFVVALFLVPNLRVGDAAAQLDELNAMGLIEPPGGRGQVAALNHQRQGDHSYHIGSTDKTVSIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F371</accession>
    <name>A0A9J7F371_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Storkhead-box protein 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Stox2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027246876.1">
        <property type="nucleotide sequence ID" value="XM_027391075.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F371"/>
    <dbReference type="GeneID" id="100756787"/>
    <dbReference type="KEGG" id="cge:100756787"/>
    <dbReference type="CTD" id="56977"/>
    <dbReference type="OrthoDB" id="10020110at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019391">
        <property type="entry name" value="Storkhead-box_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040126">
        <property type="entry name" value="STOX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437:SF2">
        <property type="entry name" value="STORKHEAD-BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437">
        <property type="entry name" value="WINGED HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10264">
        <property type="entry name" value="WHD_Storkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix Storkhead-box1" evidence="2">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027246876.1"/>
        </source>
    </evidence>
    <sequence length="926" mass="102869" checksum="808C2EEBBBC22027" modified="2023-06-28" version="1">MKKTRSTTLRRAWPSSDFSDRASDRMRSRSEKDYRLHKRFPAAFAPQASRGYMTSGDVSPISMSPISQSQFIPLGEILCLAISTMNSARKPVTQEALMEHLTTCFPGVPTPSQEILRHTLNTLVRERKIYPTPDGYFIVTPQTYFITPSLIRTNSKWYHLDERVPDRSQCTSPQPGTITPSASGCVRERTLPRKHCDSCHCCREDVHSMHASTLQRKPAKDCKDPYCPPPLCQVPPTEKSKSTINFSYKTETLSKPKDGEKQSKKFGLKLFRLSFKKDKTKQLANFSAQFPPEEWPLRDEDTPTTIPREVEMEIIRRINPDLTVENVMRHTALMKKLEEEKAHRSKAGSSAHHSGRSKKSRTHRKSHGKSRSHSKTRVSKGDPSDGSHLDIPGEREYEFCDPLTRAPREGCFIIEHKGDNFIMHSNTNVIESHFPMTPEWDVSGELAKRRTEMPFPEPSRGSSHSKVHRSHSHTQDRRSRNERSNKAKERSRSMDNSKGPLGASSLGTPEDLAEGCSQDDQTPSQSYIDDSTLRPAQTIGHQRAHISPASYKEVCIPEIVGGSKEPSSACSILEPGKTPESMPSYGELSPCPAKTAVDDYFQCNTSSETVLTAPSPLGKNKEDHDTLTLVEGVKKLSPSERQTPHSSREPVGHKEESPKGPGGGPAASGGVSEGMANGRLVQHHSAEPSSLDKRKEIFSKDTLFKPLHSTLSVNSYHKSSLSLLKSHPKSPADTLPGRCEKLEPSLGTSVAQAMPTSQRQQESGGNQEASFDYYNVSDDDDSEEGANKNTEEEKNRDDVGTMQWLLEREKERDLQRKFEKNLTLLTPKETDSSSNQRATHSARLDSMDSSSITVDSGFNSPRTRESLASNTSSIVESNRRQNPALSPAHGGAGPNFNFRASTDAPTNEAEKLQKPSNCLQASVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F408</accession>
    <name>A0A9J7F408_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho guanine nucleotide exchange factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Arhgef11</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027248832.2">
        <property type="nucleotide sequence ID" value="XM_027393031.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100760875"/>
    <dbReference type="KEGG" id="cge:100760875"/>
    <dbReference type="CTD" id="9826"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23069">
        <property type="entry name" value="PDZ_ARHGEF11-12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08753">
        <property type="entry name" value="RGS_PDZRhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000010">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000006">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000033">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000072">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037889">
        <property type="entry name" value="PDZRhoGEF_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF1">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="786"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1017"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="625"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1132"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1174"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1336"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1425"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1529"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="653"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1427"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1544"/>
            <end position="1553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027248832.2"/>
        </source>
    </evidence>
    <sequence length="1576" mass="174331" checksum="F23C5B4C34F28F80" modified="2023-06-28" version="1">MSIRLPHSIDRSASKKQSHLSRLSSLSSLGDSTPERTSPSHHRQPSDTSETTGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSSIGVSGLQQTPSLAGIPRVNPMIPPPPPPPPLPPPQHITGPKPLQDPEVQKHATQILRSMLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGLKDLNALCGESSKRREDGRLSLDSQEADSGLDSGTERFPSISESLMNRNSVLSDPGLDSPQTSPVILARVAQHHRRQGSDASVLPPNDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSHPAHLAVFLRYIFSQADPGPLLFYLCSEVYQQTNPKDSRSLGKDIWTIFLEKNAPLRVKIPEMLQAEIDLRLRNGEDPRSVLCEAQETVMLEIQEQINDYRSKRTLGLGSLYGENDLLDLDGDPVRERQMAEKQLAALVDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSSTAEKAQSAPDKDKWLPFFPKTKKQSSNSKKEKDALEDKKRNPILRYIGKPKSSSQSTFHIPLSSVEVKPGNVRNIIQHFENSHQYDVPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSASSLSTRSLENPTPPFTPKTGRRSIESPNLGFCSDVVLPHLLEDDLGQLSDLEPEPDVQNWQHTVGKDVMAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIRDIGDLMLARFDGPAREELQQVAAQFCSYQSVALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLENIIKHTEGGTPEHEKLCRARDQCREILKFVNEAVKQTENRHRLESYQKRLDATALERAINPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLQVLLLEDLLVLLQRQEERLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSELGPPQIYELVALTSSDKNIWMELLEEAVQNATKHPGSAPTPIHPSPPGSQELAYQGSTPNRVEINDSEVYHNEPEPKELSGGPGPQQRDQEKQLVAQEEPEQEEDAEELRALPHPPPSLDGGIRTRDPVLLALTGPLLMEGLADAALEDVENLRHLILCGLLPGHTVKTQAAGEPEDDLTPTPSVISITSHPWDPGSPGQAPTVGDNTQLLRPEGSQPEGEDLALYSLAHLPPRTRNSGIWDSPELDRNPAEEASSTEPTGSYKVVRKVSLLPGGGVGAAKVAGSKIIPALPESGQSESEISEVEGGAQATGNCFYVSMPAGPLDSNTEPTGTPLSPSQPHSLPTWPTEPRYQRGGIEDQICSTCSPPNLVLRDVGIIFHTIEQLTIKLHRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDHSLSPPAKEALASDSQNSQEQGSCPEGSDTPMEDSATDTAASPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F542</accession>
    <name>A0A9J7F542_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Nmd3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007642054.3">
        <property type="nucleotide sequence ID" value="XM_007643864.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247582.1">
        <property type="nucleotide sequence ID" value="XM_027391781.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F542"/>
    <dbReference type="GeneID" id="100759050"/>
    <dbReference type="KEGG" id="cge:100759050"/>
    <dbReference type="CTD" id="51068"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="249"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="313"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027247582.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57604" checksum="629479D482775DA5" modified="2023-06-28" version="1">MEYMTESVDRSPGHILCCECGVPISPNPANVCVACLRSKVDISQGVPKQVSISFCKQCQRYFQPPASWVQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMCGDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQGTVPCRYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMSQICICIRVTSAIHLIDPNTLQVADIDGNTFWSHPFNSLCHPKQLEEFIVMECSIVRDLKRSAGAGIISKKHTLGEVWIQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARDREDMDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSTVPVESDTDDEGAPRISLAEMLEDLHISQDATGEEGASMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FDF9</accession>
    <name>A0A9J7FDF9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-methylmethionine--homocysteine S-methyltransferase BHMT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Bhmt2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the regulation of homocysteine metabolism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Homotetramer.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027257521.1">
        <property type="nucleotide sequence ID" value="XM_027401720.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FDF9"/>
    <dbReference type="GeneID" id="100754773"/>
    <dbReference type="KEGG" id="cge:100754773"/>
    <dbReference type="CTD" id="23743"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061627">
        <property type="term" value="F:S-methylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071267">
        <property type="term" value="P:L-methionine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000003">
        <property type="entry name" value="Betaine--homocysteine S-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051524">
        <property type="entry name" value="BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120:SF3">
        <property type="entry name" value="S-METHYLMETHIONINE--HOMOCYSTEINE S-METHYLTRANSFERASE BHMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027257521.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40441" checksum="A4BC1CDBE0284F5D" modified="2023-06-28" version="1">MEPVGRPRAKKGILERLDSREVVVGDGGFLFTLEKRGFVKAGLWTPEAVVEHPSAVRQLHTEFLRAGADVLQTFTFSATEDNMESKWENVNAVACDLAREVADGGNALVAGGLCQTSLYKYHKDETRIKTLFRQQLEVFARKNVDFLIAEYFEHVEEAVWAVDVLREVGKPVAVTMCIGPEGDMHDVTPGECAVRLAQAGANIIGVNCRFGPQTSLQTMRLMKEGLRDSGLQAHLMVQCLGFHTPDCGKGGFVDLPEYPFGLEPRVATRWDIQKYTREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPLASEKHGSWGSTLDMHTKPWIRARARREYWENLLPASGRPFCPSLSKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FE85</accession>
    <name>A0A9J7FE85_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="9">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113833845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:24565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:25480"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25481"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="9"/>
    <dbReference type="RefSeq" id="XP_027254979.1">
        <property type="nucleotide sequence ID" value="XM_027399178.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FE85"/>
    <dbReference type="GeneID" id="113833845"/>
    <dbReference type="KEGG" id="cge:113833845"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000002">
        <property type="entry name" value="Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF28">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID COENZYME A TRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039924172" description="Succinyl-CoA:3-ketoacid-coenzyme A transferase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="10">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027254979.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="57190" checksum="F215BD45E05FB477" modified="2023-06-28" version="1">MAALRLLAWALPRRVSARSPRPALPHYLALRFASDRCSHRSGRVYFYTDPVKALEGVKDGSTVMLGGFGLCGIPENLIAALKTKGVKDLKIVSSNVGVDDFGLGILLASKQVKRVVCSYLGENQLCEQLYLAGELDLEMTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGAPIRYSPNGHLVTLSQPREVREFQGRHYLLEHAIRADFALIKGWKADRSGNVIFRGSAFNFNVPMCKAADISVVEVEEIVDVGSFRPEDIHVPNIYVDRVIKGPKFEKRIERLTTRDSTPATMSKQQESSRTRIIKRAALEFEDGMYANLGIGIPLLASNFISPKMKVYLHSENGILGLGPFPSKNEVDADIINAGKQTVTVIPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMVPGQKVKGMGGAMDLVSGDKTKVVVTMEHCTKKKQPKILEKCTMPLTGKRCVNLIITEKAVFDVDPKKGLTLVELWEGSSLDEVKATTGCAFKVSPDLKPMQQIKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FQM1</accession>
    <name>A0A9J7FQM1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CREB-regulated transcription coactivator 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Crtc3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TORC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027264063.1">
        <property type="nucleotide sequence ID" value="XM_027408262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FQM1"/>
    <dbReference type="GeneID" id="100751622"/>
    <dbReference type="KEGG" id="cge:100751622"/>
    <dbReference type="CTD" id="64784"/>
    <dbReference type="OrthoDB" id="8947034at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024786">
        <property type="entry name" value="TORC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024785">
        <property type="entry name" value="TORC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024784">
        <property type="entry name" value="TORC_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024783">
        <property type="entry name" value="TORC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589:SF4">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12886">
        <property type="entry name" value="TORC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12885">
        <property type="entry name" value="TORC_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12884">
        <property type="entry name" value="TORC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transducer of regulated CREB activity N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity middle" evidence="12">
        <location>
            <begin position="159"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity C-terminal" evidence="13">
        <location>
            <begin position="539"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027264063.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="66460" checksum="227CE1503F23275A" modified="2023-06-28" version="1">MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSTSEFQPSFHQADNVRGTRHHGLVERPARNRFHPLHRRSGEKPGRQFDGNTFAANYSSQPLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGSQSPWPAPYMGFCDGENDGHGEVASFPGLLKEESLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNMGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTSMSVGNSVGNLPAAMTHLGIRNSSGLQSSRSNPSIQATLNKTGLSSSFNSHPQTSVANASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQVFSRQLSSTSPLNPYPASQVVSSEQNPLSFLPTEAQAQVSPPPPYPTPQELPQPLLQQSHAQEAPAHPPQAAPSLPQSDFQLLTAQGSSLTNFFPDVGFDQQPMRPSPAFPQQVPLVQQSHREPQDSFHLRPNPYSNCGNFPNTILTEDPSTSLFKGLSGGLSGMPEVGLDMDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FXI2</accession>
    <name>A0A9J7FXI2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Ddx10</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression.</text>
    </comment>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with AIM2; this interaction promotes AIM2 stability. Interacts with SCNA; this interaction causes DDX10 mislocalization to the nucleoplasm and cytoplasmic inclusions.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="RefSeq" id="XP_027270900.1">
        <property type="nucleotide sequence ID" value="XM_027415099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FXI2"/>
    <dbReference type="GeneID" id="100752733"/>
    <dbReference type="KEGG" id="cge:100752733"/>
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    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="100"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="300"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="571"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="702"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="775"/>
            <end position="789"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="797"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053775"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00062067"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
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            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027270900.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="101309" checksum="CAED9B2B06044E55" modified="2023-06-28" version="1">MGKTVDSLGQGTRPDPVRSFNRWKKKHSHRQNQKKERRKQLKKPEWQVEREGISRLMQNYEKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLIPVLEALYRLQWTSADGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETICFHATNLQMLVLDEADRILDMGFADTMNAIIENLPKKRQTLLFSATQTKSVKDLARLSLKDPEYIWVHEKAKYSTPATLEQNYIVCELHQKISVLFSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGISILALHGRQQQMRRMEVYNEFLRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEEQGMVQQLLQKKVPVKEIKINPEKLIDVQKKLESFLAQDQDLKERAQRCFVSYIRSVYLMKDKEVFNVSKLPITEYALSLGLAVAPRIRFLQKMENQPTKGLVRNQATEAIQPRAPSLTNDEVEEFRAYFSEKMSILHKSGKRLEETECTLASGDSEEQDEDTEDEEMEKQLRKAGAPRTEPVLNIEEAQKEAKEVPVQFFDRDDDDEDGPDTDFLTVKRRDVFGLDLKENEALSKKEPSKSSVKKKLTKVAEAKKIVKRNFKVNKKITFTDEGELVQQWPQIQKSATNDVEEEDDTGGINLDKAKERLQEEDKFDKEEYRKKIKAKHRERRLKEKEARREDNKRQTKARDEEEAFLDWSDEEDGGFDPSTLPDPDKYRSSEESESEDIKQNMSDTKKKQGMRKRNNTEEDLDDVQPRSRHGKKAKWETLEPLDTGLSLAEDEELVLHLLKSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G8R4</accession>
    <name>A0A9J7G8R4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Metalloendopeptidase</fullName>
            <ecNumber evidence="19">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Astl</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts (via N-terminal domain) with SPACA3; the interaction occurs during fertilization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Cortical granule</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_027277702.1">
        <property type="nucleotide sequence ID" value="XM_027421901.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G8R4"/>
    <dbReference type="GeneID" id="100750643"/>
    <dbReference type="KEGG" id="cge:100750643"/>
    <dbReference type="CTD" id="431705"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060473">
        <property type="term" value="C:cortical granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000036">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF855">
        <property type="entry name" value="ASTACIN-LIKE METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7 18 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 18 19" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039962235" description="Metalloendopeptidase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="21">
        <location>
            <begin position="86"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027277702.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="47873" checksum="538FA1348500D6E2" modified="2023-06-28" version="1">MGSVGDLRPWMLVLLSLLGLILAAPLAPRCSDGVCSTSVPEGFTSEGSQVSQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNKWPKSVGGIVEIPFLLSSKYDESSRRVIMEAFAEFERFTCIRFVAYQGHRDFISILPMSGCFSGVGRSGGMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHSRADRDRYIRVNWNEILPGFEINFIKSRSSNMLVPYDYSSVMHYGRFAFSWRGQPTIIPLWTSSVAIGQRWNLSTSDITRVCRLYNCSQSVPDSHRRGFEAHNDGRSLSPASLSHLQRLLEALSEESRNSAPSGSRTGGQGIIPRLVDSQQRWEHLAQSKFSVEASATPPQRLAASPRSGPGAGADGISLGQFQAAQVPTALPTPFPETRDQPAPIQDALESLALLPGGCAPGSHFKEVPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GA44</accession>
    <name>A0A9J7GA44_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Surfeit locus protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Surf6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027278792.1">
        <property type="nucleotide sequence ID" value="XM_027422991.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GA44"/>
    <dbReference type="GeneID" id="100771435"/>
    <dbReference type="KEGG" id="cge:100771435"/>
    <dbReference type="CTD" id="6838"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027278792.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="41287" checksum="CC4D7E41D91C0B64" modified="2023-06-28" version="1">MASLQAKDAYLQDLAKKICAQPGPERQRSEWAVKTKRLEAAELPKKKRKKAQKKSQEQKATEHKTKPLVKTAPPSSRAKKPMESKQEKNSSSLESPEDSQVTAPDSVFALDFLRQRLHEKIQLARGQGSTKELSAATLEKRQRRKQERERKKRKRKELRAKEKAAKTEKKEEPAEAPPEVPCKEPQASGLMFNKVEVTEEEPASKAQRRKEKRQKVKGNLTPLTGRNYRQLLERLQARQDRLEELRDQDAGKAQELEAKMKWTNLLYKAEGVKIRDNERLLQEALKRKEKRKAQRQRRWEKRSEHVVEKMQQRQDKRRQNLRKKKAARAERRLQKARKKGRVLPQDLERAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GHQ5</accession>
    <name>A0A9J7GHQ5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Gem-associated protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Gemin5</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Gem</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the WD repeat gemin-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283223.1">
        <property type="nucleotide sequence ID" value="XM_027427422.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100766595"/>
    <dbReference type="KEGG" id="cge:100766595"/>
    <dbReference type="CTD" id="25929"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097504">
        <property type="term" value="C:Gemini of Cajal bodies"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000213">
        <property type="entry name" value="gem-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000221">
        <property type="entry name" value="gem-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056432">
        <property type="entry name" value="Beta-prop_GEMI5_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056424">
        <property type="entry name" value="Beta-prop_GEMI5_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056420">
        <property type="entry name" value="GEMI5_RBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052640">
        <property type="entry name" value="Gemin-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23770">
        <property type="entry name" value="Beta-prop_RIG_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23775">
        <property type="entry name" value="Beta-prop_RIG_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23777">
        <property type="entry name" value="GEMI5_RBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 19" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 first beta-propeller" evidence="21">
        <location>
            <begin position="80"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 second beta-propeller" evidence="23">
        <location>
            <begin position="389"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="22">
        <location>
            <begin position="892"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 RBS" evidence="24">
        <location>
            <begin position="1157"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="729"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1304"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1389"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1406"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF23770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF23775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF23777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027283223.1"/>
        </source>
    </evidence>
    <sequence length="1505" mass="167119" checksum="3CEBC7B60142C91D" modified="2023-06-28" version="1">MKPEPRTLPPSPNWYCARCSDAAPGGIFGFAARTSVFLVHVGPGAGASPGAPPFRVVGELVGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKAVVTEHSLHQHTISALHWSPTVKDLIVSGDEKGVVFCYWLNRNDSQHIFTEPRTIFCLTCSPHHEDLVAIGYKDGIVVIIDISKKGEVIHRLRGHDDEIHSIAWCPLFGEDCLSINQEENSEEPDIPNGKLIAETPITKGCYLATGSKDQTIRIWSCSRGRGIMVLKLPFLKRRGGGVDPTVKERLWLTLHWPKNQPTQLVSSCFGGELLLWDLTQSWRRKYTLFSTSAEGQNHSRIVFNLCPLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPVDVGCLAIGVGDGMIRVWNTLSIKNNYDVKNFWQGVKSKVTALCWHPNKEGCLAFGTDDGKVGLYDTCSNKPPQISSTYHKKTVYRLAWGPPVPPMSLGGEGDRPSLTLYSCGGEGIVLQHNPWKLSGEAFDINKLVRDTNSIRYKLPVHTEISWKGDGKVMALGNEDGSIEIFQVPNLKLLCTIQQHHKLVNAIVWHHEHGSRPELSCLIASGSNNAVIYVHNLRTVLESNSESPVTITEPFRTLSGHTAKVTSLAWSPHHDGRLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVVWSPVDPECIYSGADDFCVYRWLTSMQDHSRPPQGKKCIELEKKRLSQPKPKLKKKKKPTLRLPVKQDSSIGNEEESIRENSGPIENGVSDQDGEEEAQEPELPPSPVVAGEAVSCTAVSMGFEKSKVTVSNKATSLKKEPPKEKPDALLKKRKARSMLPLSTSLDHRSKEELHRDCLILATATHAKAELNEDVSADLEERFHLGLFTDRATLYRMMEAEGKGHLESGHPELFHQLMLWKGDLKGVLEAAAERGELTDSLVAVAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHKVYEAVELLKSNHFYREAIAVAKARLRPDDPVLKDLYLSWGSILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELASIAGESELAASLALRCAQELLLVKNWVGAQEALGLHESLQGQRLVFCLLELLCRHLEEKQPPEVRSPSSVYHQWATGSEGTLVQRVTDVWRSTLSVDTPEQCRAALQKLQDVKYPSATSNTPFRQLLLHVCHDLTLAMLSQQAASWEEAVPALLQAVLRSYTSGNFTLMQEIYSAFLPDGCDHLRDKLGDLSLATAAFKSLEAFFIYGQLYEVWWALCGPVPESSIWVKSTASEEQGEPEDSTSAKDTEPGATAQPQSSQPPDPGLKLSAETEHLLSACRELFSERHASLQTFQRTVAEIQETLAEMIRQHQKSQLCKAMADGPNRDDPSQETEQLPSQPQSPSREERKTPVSLPELTRRLTEANERIAEFPESIKAWPFPDVLECCLVLLHIGSQCPGAVNPEMQQQAQELLQKYGHTRAYRRHCQTLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GLE1</accession>
    <name>A0A9J7GLE1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 120-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113838779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027290106.2">
        <property type="nucleotide sequence ID" value="XM_027434305.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GLE1"/>
    <dbReference type="GeneID" id="113838779"/>
    <dbReference type="KEGG" id="cge:113838779"/>
    <dbReference type="OrthoDB" id="9622403at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001254">
        <property type="entry name" value="Zinc finger protein 564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027290106.2"/>
        </source>
    </evidence>
    <sequence length="182" mass="21758" checksum="0CE1244878C15051" modified="2023-06-28" version="1">MTYDDVHIDFTWQEWTLLDTSQKNLYKDVMLETYKNLNDIGYSWEDNNIEEHSTSSTRHERHERSQTGLKPSVYTRCLNAFEYNSHLQRHKRRHNGEKPYECNQCGKAFGRYSHLQTHKRTHTGEKPYECDRCGKAFSQHSHLQTHKRRHTGEKPYECNQCGKAFGRYSHLQTHKRTHTGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GN24</accession>
    <name>A0A9J7GN24_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laminin A chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Lama1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294751.1">
        <property type="nucleotide sequence ID" value="XM_035438860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765555"/>
    <dbReference type="KEGG" id="cge:100765555"/>
    <dbReference type="CTD" id="284217"/>
    <dbReference type="OrthoDB" id="10011303at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043256">
        <property type="term" value="C:laminin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120036">
        <property type="term" value="P:plasma membrane bounded cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000242">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000454">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000512">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000098">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000116">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000119">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000127">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000161">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000189">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000250">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000008">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000017">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000034">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000094">
        <property type="entry name" value="Laminin subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000128">
        <property type="entry name" value="laminin subunit alpha-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000026">
        <property type="entry name" value="laminin subunit alpha-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009254">
        <property type="entry name" value="Laminin_aI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010307">
        <property type="entry name" value="Laminin_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF409">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06008">
        <property type="entry name" value="Laminin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06009">
        <property type="entry name" value="Laminin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin N-terminal" evidence="20">
        <location>
            <begin position="44"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="423"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="480"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="19">
        <location>
            <begin position="549"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="768"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="875"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="928"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="977"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="1024"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="1070"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="1116"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="19">
        <location>
            <begin position="1203"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="1429"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="1535"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="2144"/>
            <end position="2324"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="2332"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="2513"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="2741"/>
            <end position="2913"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="2918"/>
            <end position="3098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1742"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="977"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1070"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1072"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1116"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1535"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1537"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1556"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2672"/>
            <end position="2699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035294751.1"/>
        </source>
    </evidence>
    <sequence length="3103" mass="340021" checksum="D9F625FEAE5C2675" modified="2023-06-28" version="1">MATVPSVSAVVIMDTVPNVSTVTLPTVPSVSSVFTLPTVPNVNCHTGLFPAILNLATNAHISANATCGEMGPEMFCKLVEHVPGRPVRHSQCRVCDGNSTNPRERHPISHAIDGTNNWWQSPSIQNGREYHWVTITLDLRQVFQVAYIIIKAANAPRPGNWILERSVDGIKFKPWQYYAVSDTECLTRYKITPRRGPPTYRADNEVICTSYYSKLVPLEHGEIHTSLINGRPSADDPSPMLLEFTSARYIRLRLQRIRTLNADLMTLSHRDLRDLDPIVTRRYYYSIKDISVGGMCICYGHASSCPWDEETKQLQCQCAHNTCGESCDRCCPGYHQQPWRPGTIASGNECEECNCHNKAKDCYYDENVAKEKRSLNTAGQYLGGGVCINCLQNTTGINCETCLDQYYRPHTVSPYEDQPCRPCDCDPVGSLSAVCIKDDLHSDLANGKRPGQCPCKEGYAGVKCDRCQFGYRGFPNCIPCDCYTVGSVNDDPCSEPCVCKENVEGKNCDHCKSGFYNLQERNPQGCSECFCFGVSDVCDSLTWSVSQVTNMSGWLVTDLISPNMIQSQQDALGGRHQISINNTAVMQRLRATYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETVDSGLMSHADVIIKGNGLTLSTQAEGLSLQPYEEYFNMVRLVPENFRDFKTKREIDRDQLMTVLANVTHLLIRANYNSARMALYRLDSVSLDIASPNAIDLAVATDVEHCECPQGYTGTSCESCLPGYYRVDGILFGGICQPCECHGHASECDIHGICSACTHNTTGNHCEQCLPGFYGTPLHGTPGDCQPCACPLSIDSNNFSPTCHLADGENVVCDQCAPGYSGSWCERCADGYYGNPTVPGGTCVPCNCSGNVDPLEAGHCDSVTGECLKCLWNTDGAHCERCADGFYGDAVTAKNCQACNCHENGSLSGMCHLETGLCDCKPQVTGQQCDQCLPGYYGLDTGHGCVPCNCSMEGSMSDNCTEDGQCHCVPGVSGKKCDRCSHGFYGYQDGGCTPCDCAHTQNNCDPNSGECLCPPHTQGLKCEECEETYWNLDPEQGCQACNCSVAGSTGPQCDVLSGQCHCKEGFGGQSCDQCALGYRRFPDCVPCDCDLRGTLADTCDLEQGLCSCTEDSGTCSCKENVLGHQCSECRAGTFALQTDNPLGCSPCFCFGLSQLCSELEGYVRVPITLASDQPLLPVVSQSNLKGTVEGVHFQAPDTLLDAEAVRQHVHGEPFYWRLPKQFEGDQLLAYGGKLQYSVAFYSTHGTGTSNYEPQVLVKGGRARKHVIYMDAPAPENGARQDYQVQMKEEFWKYFNSVSEEHVTHSDFMSVLSNIEYILIKASYGQGLQQSRIANISMEVGRKAGELPAGGEAASPLEHCVCPPGTTGLSCQDCAPGYHRGKLPESSGRGPRPLLAPCVPCSCNNHSDVCDPETGQCLNCRDHTAGDHCEICAPGYYGMVTGLPGDCTPCTCPHRPPFSFSPTCVLEGDGGFRCNACIPGYEGQYCERCSVGYHGNPRAAGGSCQKCDCNPQGSVHSDCDRASGQCVCKPGATGLRCEECLPRHILIDSDCVSCDDECVGTLLSDLDTVGDAIQSLNLSGVSPAPYGILSSLENTTKYFQRYLLKENAKKIRVEIQLEGVAEQTENLQKELTRVLTKSQQVNKATQRTVNGTQALATFIKLLHTNITEIMERLATLNQTTREDFQPPTSALQSLHHNISSLLELIKKRNFTDLHQNATLELKAAKDLLSRIQKRFQKPQERLQSLKAASSDLLSNHSKDLQAAEELLREAETKTQESNLLLLLGKANLKEFREKTLKVQEERNLSSELITKGREWVDSATTHVDNVQDTLTHLERHRDELLLWTGKLRTHVDELVMQMSKRRARDLVHSAEQHASELQSLAGVLDRDLENVRNVSLNATSAAQVHANIQLMMEEAERLAAGAHRTSNKTGLVSESLVSQGKAVLQRTSRFLKESINARRKQQGITLKLDELKNLTSQLLESVDNITSQTNSSLYILREIPGGMREKERKARELAAAANENAMRTLENVLGLSLRVVNTSADLSRVNATVQETNDLLRNSTMTTLLAGRKMKDMETQANLLFDRLKPLKTLEENLSRNLSEIKLLISRARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTSSDFLAVEMRRGKVAFLWDLGSGSTRLEFPDVSINDNRWHSIYITRFGNVGSLSVKEISSAENPPVKTSKSPGMANVLDINNSTLMFVGGLGGQIKKSPAVKITHFKGCMGEAFLNGKSIGLWNYIEREGKCNGCFGSSQNEDSSFHFDGSGYAVVEKTLRTTVTQIIILFSTFSPNGLLFYLASNGTKDFLSIELVRGRVKVMVDLGSGPLTLMTDRRYNNGTWYKIAFQRNRKQGLLAVFDAYDTSDKETKQGETPGASSDLNRLDKDLIYVGGLPHSVSVRKGVSSRSYVGCIKNLEISRSTFDLLRNSYGVKKGCALEPIQSVSFLRGGYVEVPPKSLSPESSLLATFTTKNSSGIILAALGKDSERAGWSQAHVPFFSIMLMEGHIEVHVSSGDGLSLRKALLHSPAGSYSDGQEHSISLVRNRRVITIQMDESSPVEMKLGPLAEGKTINISNLYIGGLPGDKGAPMLRMRTSFHGCIKNLVFDTELLDFTHAIGSEQVELDICLLAEEPTQDLHGEHGELPPDPPTLPQPELCTVDAAPGYVPGAHQFGLSQNSHLVLPFNHSDIRKRLQVQLSIRTFASSGLIYYVAHQNQMDYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTEYIKRKGFMTVDGQESPTVTVVGNATTLDVDGKLYLGGLPVNYRARNIGNTTHSIPACIKEVTVNGKQLDKDSPMSAFAVDRCYAVAQEGTFFEGSGYAALVKEGYRVRLDLNITLEFRTSSKNGVLLGISSAKVDAIGLEIVDGKVLFHVNNGAGRITATYEPRASRNLCDGKWHTVQAQKIKHRIVLTVDGNAVRAESPHTHSTSADTNDPIYVGGYPAHVKQNCLTSKTSFRGCVRSLKLTRGPQVQSLDLSRAFDLQGVFPHSCPGPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQM7</accession>
    <name>A0A9J7GQM7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100757460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007651380.1">
        <property type="nucleotide sequence ID" value="XM_007653190.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289705.1">
        <property type="nucleotide sequence ID" value="XM_027433904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GQM7"/>
    <dbReference type="GeneID" id="100757460"/>
    <dbReference type="KEGG" id="cge:100757460"/>
    <dbReference type="OrthoDB" id="9564575at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003092">
        <property type="entry name" value="Si:dkey-14o6.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000992">
        <property type="entry name" value="Zinc finger protein 320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001239">
        <property type="entry name" value="Zinc finger protein 615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000466">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
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        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
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        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
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        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
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        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
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        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
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        </source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    <evidence type="ECO:0000313" key="17">
        <source>
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    <sequence length="720" mass="84040" checksum="C78594E1F75D1FA9" modified="2023-06-28" version="1">MTDSPVNMSQGVLTFRDVTVDFPQEEWECLDSAQRALYIDVMLENYSNLVSVENYCKCDPVHHHVKTEKESCQCNELGKVLHDPATCALYRTSETTENSSNYTCSNPRDASGDSSNPDRRESRHTGEEPCSSKDCEKSVNLCSNMTQDQRVYTAEKEHRQGEYEDYFMSTYSLLQLPIYIGEKPHQCEKCRKCFRTASSLSVHRRIHSGKKPYKCNICGKSYNQFANLRIHHRLHTGEKPYKCKECGKSFRQSSALKSHLKIHTGEKPYKCKECGKSFAHCSSFRTHQKIHSDEEHCSCQECGKVFHQLSHFRRHYRLHSGEKPYKCTECDRAFAHYSSLRWHQKTHSLETFYKCEECGKSFLELSHLKRHYRIHTGEKPYKCEVCDKSFTVNSTLKTHQKIHTGEKPYKCRECDKSFTKCSHLRRHQSVHTAEKLYSCKECGKSFPECSALREHQKIHTGEKPYKCAECDKSFFQQSNLRTHQRVHTGERPYRCKDCGKSLTTLSTLRAHQKTHTAEKPYKCVECDKSFTHNSHLRTHQRVHTGERPYSCQECGKSFTTCSYLRAHQKTHTGEKPYKCKDCDMSFLRISSLKIHQKIHTGEKPFKCKDCDLSFNQISNLKRHQKLHTGEKPYKCLECDKSFAHLSNLRTHQRVHTGERPYKCKDCDKSFTRCSYLRAHEKIHTGETLHKCKDCDMSYIHLSNLRRHQRVHTTEKSICGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GSM1</accession>
    <name>A0A9J7GSM1_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">Endogenous retrovirus group K member 19 Env polyprotein-like</fullName>
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        <name evidence="3" type="primary">LOC118238492</name>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Myomorpha</taxon>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">17A/GY</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
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            <begin position="1"/>
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            <begin position="1"/>
            <end position="15"/>
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            <begin position="19"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035297538.1"/>
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    <sequence length="221" mass="24794" checksum="5A65187E6E42656B" modified="2023-06-28" version="1">MPTPPSGSQIGSSGPQRDKQRRKRKWQKQQKQLVTQKKKIKLPSSQTRRITWTKIKHLMKEAKTLLKQQGKLLTASMNFLAILALISTPPSVEGVAYWAYIPNPPILQPVGWLDQEPIRVLTNDTVRMGGARDSDARASSSSLITFEGRADSLPICITLQGKVPEGCLSTGYRTFLTDGPDKESAALWPKYSKKSLSCNLKIKNGELLRPRRSRLCSRRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <name evidence="18" type="primary">Sptbn2</name>
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        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
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    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probably plays an important role in neuronal membrane skeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297936.1">
        <property type="nucleotide sequence ID" value="XM_035442045.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100758389"/>
    <dbReference type="CTD" id="6712"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CH_SPTB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21321">
        <property type="entry name" value="CH_SPTBN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000003">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000028">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000049">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000059">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000106">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000130">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000179">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000373">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 12" id="KW-0117">Actin capping</keyword>
    <keyword evidence="9 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="69"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="188"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="2230"/>
            <end position="2340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2092"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2345"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1112"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1437"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2092"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2136"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2380"/>
            <end position="2393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035297936.1"/>
        </source>
    </evidence>
    <sequence length="2400" mass="272470" checksum="2CB9142AC6A9474A" modified="2023-06-28" version="1">MSSCRNRKPPTTMSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAEHLVEKYESLASELLQWIEQMIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAEQYHDIKRISARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADITVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVASLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQAAARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEEEIRAHRPTLDALREQAAALPPALSHTPEVQGRVPSLEQHYEELQTRAGERARALEAALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALGARVTAVNDIAEQLLKANPPGKDRIIGTQQQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRTLGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADVAIKKLEDFMSTMDANGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQSAGEVERTSRAVEEKFRALCQPMKERCQRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLKDRQRALGAAAAGPELAELQEMWKHLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHDHPESTRLTIRQAQVDKLYASLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLISGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGQELLARSHYAAEEISEKLSQLQSRRQETADKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEEREKERKRKREEEERRKQPSTPEPMASRPDGSLIDGQKAPDTAWDGSQSQLPPSTQAPSINGVCTDTESSQPLFEQQRLEQSSVPEGPGSGTGDESNGPRGERQTRPRGPAPSPMPQSRSSESAHVATLPTRGPELSAQEQMEGMLCRKQEMEAFNKKAANRSWQNVYCVLRRGSLGFYKDARAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSASRGLTRAMTMPPVSQPEGSIVLRSKDGREREREKRFSFFKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2T6</accession>
    <name>A0A9J7H2T6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Titin</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Connectin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">Ttn</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
            <tissue evidence="32">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035302231.1">
        <property type="nucleotide sequence ID" value="XM_035446340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767264"/>
    <dbReference type="KEGG" id="cge:100767264"/>
    <dbReference type="CTD" id="7273"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055008">
        <property type="term" value="P:cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055003">
        <property type="term" value="P:cardiac myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
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    <sequence length="26855" mass="2983879" checksum="F6D37A4798E9EEBD" modified="2023-06-28" version="1">[encoded data, 26855 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4J2</accession>
    <name>A0A9J7H4J2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein 28 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100772906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035305408.1">
        <property type="nucleotide sequence ID" value="XM_035449517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4J2"/>
    <dbReference type="GeneID" id="100772906"/>
    <dbReference type="KEGG" id="cge:100772906"/>
    <dbReference type="OrthoDB" id="9836105at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF158">
        <property type="entry name" value="KRAB DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="2">
        <location>
            <begin position="113"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035305408.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20674" checksum="D132F214689A2AF3" modified="2023-06-28" version="1">VQWAGPGGAAPRNWLKGPEISPFPVGLGEPRAADPGAEDTAGPRGPETSGSAVSALAGRPGKVSSQQRSGGNRSRAALKAPRFTDHPDLLTCAAEQRGLEGERRQKLKMQGLVTFSDVTVTFSKEEWECMDSAQWNLYTDVMLANYNNLVFVVASTQSQSGVSVQSGPENNPMRKVKNTAVYGAQTVEDRNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4X0</accession>
    <name>A0A9J7H4X0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: opioid growth factor receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC113837352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305082.1">
        <property type="nucleotide sequence ID" value="XM_035449191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113837352"/>
    <dbReference type="KEGG" id="cge:113837352"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF1">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="87"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035305082.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="55242" checksum="6717F33A896A76CB" modified="2023-06-28" version="1">MESRSCLLRMDDPDYDSTWEDESKEGCEDGQADEKGHEDKGSKHSNAKEPRPGVFQSRKTWYRNWRAMQDMRRYRHHYPDLADQDCNGDMTNLRFYKNEICFQPNGLYIEEILHNWKDNYFVLEENHSYIQWLFPLREPGVNQHAKPLTLKEVEAFKSSQEVKERLVRAYELMLGFYGIQLEDRDTGAVCRAQNFQPRFQNLNSHRHNNLRITRILKSLGELGLEHYQAPLVRFFLEETLVQHQLPSVRQSVLDYFMFAIRCRHQRRELVYFAWEHFRPRCQFVWGPRDKLQRFRPHGKPRPLMVLGQADKDEGSGKPFQEAGTQGQTYGSGRDLSGSSGKAEDPSLLSTKPQESGALDEAQGDETESLSSKESKKRKXEEKRQEQVPGASDVKNTALNLEVCALSCVSQKPREADQACPVTHGARVADETRKQRKMEKRAEGDXVASNYHTDMQAHAPLPTTSESPLLPRLAWNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H892</accession>
    <name>A0A9J7H892_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 775</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Znf775</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304455.1">
        <property type="nucleotide sequence ID" value="XM_035448564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H892"/>
    <dbReference type="GeneID" id="100773995"/>
    <dbReference type="CTD" id="285971"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000191">
        <property type="entry name" value="zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000530">
        <property type="entry name" value="zinc finger protein 775"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000979">
        <property type="entry name" value="Zinc finger protein 775"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035304455.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="67428" checksum="20505CFA11B6FAC6" modified="2023-06-28" version="1">MAGAGDQGAGLRPHQHSGRPSGMESGLTGNGSGDGLVGIKQEKPEWQLQAVVSQASLPEKDKENIFLQPGGLPPCQTMGRPWALGSQEEVGGAWWAPPPEQDAGLEARVPGTAPGPLSPALSGGGGHFVCMDCGKRFSWWSSLKIHQRTHTGEKPYLCSKCGKSFSQKPNLERHQRHHTGERPFCCLECPRRFSQKQHLLKHQKTHTRPTTHPCPECERCFRHQVGLRIHLRVHARDRLGVHVSLHEMLPYAARRRRACRLRPGSPRGRPEWVWLGLYQGWWGQHKVRTAAHSRLCPSEQRQFICNECGKSFTWWSSLNIHQRIHTGERPYGCPECGRRFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQKQHLLKHLRTHLPGGQAARCTSCGQNCPSRAALRAHQRMHAATELLRSRSAVQGGVPGSESQAETVQSVAVKPHGSQGAKKVPCGQGCETLAASSEQRQFICNECGKSFSWWSALTIHQRIHTGERPYACPDCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQKQHLLKHQRVHRGAQAPHPGPEEEEEPYMSDLRTPWRGPSFYSHWAQAQSAKPQLPAPSVWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HB87</accession>
    <name>A0A9J7HB87_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Platelet-derived growth factor receptor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Pdgfrl</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a complex composed of PDGFRL, TNK2 and GRB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035297723.1">
        <property type="nucleotide sequence ID" value="XM_035441832.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308894.1">
        <property type="nucleotide sequence ID" value="XM_035453003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HB87"/>
    <dbReference type="GeneID" id="100774739"/>
    <dbReference type="KEGG" id="cge:100774739"/>
    <dbReference type="CTD" id="5157"/>
    <dbReference type="OrthoDB" id="9864753at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005017">
        <property type="term" value="F:platelet-derived growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000223">
        <property type="entry name" value="Platelet-derived growth factor receptor beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000907">
        <property type="entry name" value="Platelet-derived growth factor receptor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001395">
        <property type="entry name" value="Platelet-derived growth factor receptor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042495">
        <property type="entry name" value="PDGFRL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360:SF1">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21339">
        <property type="entry name" value="VEGFR-1-like_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="68"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="278"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035308894.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42334" checksum="26A9F761242204B5" modified="2023-06-28" version="1">MSLHMRAIVSSPSLESGMCKSDVQVAGQQPPKSKRPKEQGDNRIKPTNKKAKPKIPKIKDRDSADTPPKSQSIMVQAMDGGRFQKPAATMSLMAGQTVELRCKGSKVEWSYPTYLDTFKDSRLSVKQNERYGQLTLVNSSSADTGEFSCWGQLCNGYICRRDESRTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPVNGTDIIYDMKRGFVYLQPHSDHQGVVYCKAEAGGKSQISVKYQLLYVEVPSGPPSTTILASSNKVNGGDDISVLCTVLGEPDVEVEFRWIFPGQKDERPVAIQDTWRLINRGLGHTTRISQSVITIEDFETIDAGYYICTAQNLRGQTTVATTVEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HC91</accession>
    <name>A0A9J7HC91_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113838738</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative pheromone receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309574.1">
        <property type="nucleotide sequence ID" value="XM_035453683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HC91"/>
    <dbReference type="GeneID" id="113838738"/>
    <dbReference type="KEGG" id="cge:113838738"/>
    <dbReference type="OrthoDB" id="9606139at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016503">
        <property type="term" value="F:pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000033">
        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035309574.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38801" checksum="390119DD9FC23A49" modified="2023-06-28" version="1">MYLWNLTIKIIVLSLTTIGILGNISVFYYYLICYGDSKLKTVDLIHMHLMAANTLIILSTGVPHTMAAFGLKQFLNDFGCRLILYIVRVGRSMSIGTTCLLSVFQAVTISQKESCCKDQKVKAAKYIGCTLSLVWASYILIHFIFFVYPIIKSYSNNVTSKRDFGHCSTAGRDGINDSLYAALVVCPEICFSLLMAWSSGSMIVILYRHKQRVQHIRSTCVSIRNFPESRATHNILVLVSTFLAFYTLSAILQGCIALLHNHSCWLVNNTRLTSLCFPSFAPLVLMNHYSRLPRLILVQHKEYKSLILILIPVKGATCKLQCLFAKLESPDMMITTKFHNHSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HFW9</accession>
    <name>A0A9J7HFW9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC113837597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309743.1">
        <property type="nucleotide sequence ID" value="XM_035453852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113837597"/>
    <dbReference type="KEGG" id="cge:113837597"/>
    <dbReference type="OrthoDB" id="10251209at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000538">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035309743.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44762" checksum="8F455D6E5DBBEE56" modified="2023-06-28" version="1">MDSQSRKLVVCNNGTRFVKCGYAGSNFPEHIFPYLVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPIENDIVKNWDDMKHLWDYTFGQEKLNIDSRNCKVLLTEPPMKPTKNREKIVEVMFETYQFSCVYVAIQAVLSLYAQGLLTGVVIDSGDGVTHICPVYEGFLLPLLKRRLNIAGRDISRYLXKLLQLSGHAFNHSADFEXVRMIKEKLCYVDYIIELEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLISVEGVGVAELLFNTIQAADIDTRFEFYKHIVLSGGSTMYHGLPSRLEREVKQLYLEQVLKGDVENLSKFKIRIEDPPCRNHMVFLGGAVLADILKDKDNSGRTLQEYQEKGVLVLEKLSLPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J902</accession>
    <name>A0A9J7J902_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipid scramblase CLPTM1L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cisplatin resistance-related protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cleft lip and palate transmembrane protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Clptm1l</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)</text>
            <dbReference type="Rhea" id="RHEA:71495"/>
            <dbReference type="ChEBI" id="CHEBI:190691"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)</text>
            <dbReference type="Rhea" id="RHEA:71491"/>
            <dbReference type="ChEBI" id="CHEBI:57997"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255934.1">
        <property type="nucleotide sequence ID" value="XM_027400133.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J902"/>
    <dbReference type="GeneID" id="100773964"/>
    <dbReference type="KEGG" id="cge:100773964"/>
    <dbReference type="CTD" id="81037"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027255934.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="63081" checksum="17DC1D95FEA28AC5" modified="2023-06-28" version="1">MWSGRSSFTSLVVGVFVVYVVHTCWVMYGIVYTRPCSGDANCIQPYLARRPKLQLSVYTTTRSSLGAENNVDLVLNVEDFDVESKFERTVNVSVPKKTRNNGTLYAYIFLHHAGILPWHDGKQVHLISPLTTYMIPKPEEINLLTGESAAQQQIEAEKKPSNALDEPVSHWRPRLTLNVMVDDFVFDGSSLPADVHRYMKMIQLGKTVHYLPILFIDQLSNRVKDLMVINRSTTELPLTVSYDKISLGRLRFWIHMQDAVYSLQQFGFSEKDADEVKGIFVDTNLYLLALTFFVAAFHLLFDFLAFKNDISFWKKKKSMIGMSTKAVLWRCFSTVVIFLFLLDEQTSLLVLIPAGIGAAIELWKVKKALKMTVTWRGLRPVFQFGTHSESERKTEKYDAQAMKYLSYLLYPLCVGGAVYSLLNIKYKSWYSWLINSFVNGVYAFGFLFMLPQLFVNYKMKSVAHLPWKAFTYKAFNTFIDDVFAFIITMPTSHRLACFRDDVVFLVYLYQRWAVLLEWEVAELKSITTTDRVLRARNRLELVCVTVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J946</accession>
    <name>A0A9J7J946_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-related GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Rraga</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003514182.2">
        <property type="nucleotide sequence ID" value="XM_003514134.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256178.1">
        <property type="nucleotide sequence ID" value="XM_027400377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J946"/>
    <dbReference type="SMR" id="A0A9J7J946"/>
    <dbReference type="GeneID" id="100761704"/>
    <dbReference type="KEGG" id="cge:100761704"/>
    <dbReference type="CTD" id="10670"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000276">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF7">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027256178.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36566" checksum="B0DA1FC8FA6B766A" modified="2023-06-28" version="1">MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J9A5</accession>
    <name>A0A9J7J9A5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pleckstrin homology-like domain family A member 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100761451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027248220.1">
        <property type="nucleotide sequence ID" value="XM_027392419.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J9A5"/>
    <dbReference type="GeneID" id="100761451"/>
    <dbReference type="KEGG" id="cge:100761451"/>
    <dbReference type="OrthoDB" id="9630709at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042832">
        <property type="entry name" value="PHLA1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478:SF4">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="159"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027248220.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46391" checksum="23F260F556C05A6F" modified="2023-06-28" version="1">MRRTPAAERLSELGFPPRCGRQEPPFPLGVTRGWGGWPIEKRREGARPVPFSERSREDGREQPARGSGILWRVRTRLSLCRDPEQPPPPPPPPPPPPLCLLRVSFLCALRAGGRGSRWSEDGARLLLLPPARASGSRKAERSSSTPYAGRMLESSGCKALKEGVLEKRSDGLLQLWKKKCCILTEEGLLLIPPKQLQQQQQQQQQQPGQGTAEPSQPSGPTVAGLEPPVKLKELHFSNMKTVDCVERKGKYMYFTVVMAEGKEIDFRCPQDQGWNAEITLQMVQYKNRQAILAVKSTRQKQQHLVQQQPPQTQQIQPQPPQPQPQPQPQPQSQPQIQPQPQIQPQPQIQPQPQPKPQPQQLHSYPHPHPHAHPHPHPHPHPHPHPHQLQHAHQPPHSLPHGHRLLRSTSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JIF9</accession>
    <name>A0A9J7JIF9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING finger protein 150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Rnf150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027261934.2">
        <property type="nucleotide sequence ID" value="XM_027406133.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JIF9"/>
    <dbReference type="GeneID" id="100774190"/>
    <dbReference type="KEGG" id="cge:100774190"/>
    <dbReference type="CTD" id="57484"/>
    <dbReference type="OrthoDB" id="5357315at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02122">
        <property type="entry name" value="PA_GRAIL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16805">
        <property type="entry name" value="RING-H2_RNF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000016">
        <property type="entry name" value="Ring finger protein 150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF27">
        <property type="entry name" value="RING FINGER PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="371"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027261934.2"/>
        </source>
    </evidence>
    <sequence length="531" mass="57688" checksum="D547D9B98041B3F4" modified="2023-06-28" version="1">MREGDAEPRSRTPGSPTPPQARGARSVSPPLSPGKPDASAARRLRGDRAGFARSPGIRSPQRLRVPAGAPPAREKDGAGGGRRGRGGDPGERREVAMSLIQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYAEPEPGAAVAGGGGGAELHTEKTECGRYGEHSPKQDARGEVVMASSAHDRLACDPNTKFAAPAHGKHWIALIPKGNCTYRDKIRNAFLQNASAVVIFNVGSNTNETITMPHAGVEDIVAIMIPEPKGKEIVSLLERNITVTMHITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRNQRRLGDAAKKAISKLQVRTIRKGDKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALGIPPNADCMDDLPIDFEGSLGGPPTNQITGASDTTVNESSVTLDPAVRTVGALQVVQDPDPVPQEGEAIFTTNSDQEPAVSSGSDISLIMALDVGLSDVELSTDQDYEEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JIY2</accession>
    <name>A0A9J7JIY2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Max dimerization protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Max-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Mxd3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027265615.1">
        <property type="nucleotide sequence ID" value="XM_027409814.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301240.1">
        <property type="nucleotide sequence ID" value="XM_035445349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JIY2"/>
    <dbReference type="GeneID" id="100764445"/>
    <dbReference type="KEGG" id="cge:100764445"/>
    <dbReference type="CTD" id="83463"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF6">
        <property type="entry name" value="MAX DIMERIZATION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027265615.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27111" checksum="1799A2D80C07629D" modified="2023-06-28" version="1">MEPVASNIQVLLQAAEFLERREREAEHGYASLCPHHGPGAVYRRRKRPLQAPGALNSGRSAHNELEKRRRAQLKRCLEQLRQQMPLGVDCPRYTTLSLLRRARVHIQVDEMCYLEVVDGKWQDAGSIPSGLAPARLLSTLHKLEEQEQQAQRLKEKLRSEQQSLQQQLEQLQGLPGAGERDRPRADSLDSSVLSSERSDSDQEDVEVDVESLVFGTETELLPRLSTSQGLGYSHSTSTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JKS7</accession>
    <name>A0A9J7JKS7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Prolyl endopeptidase FAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Fap</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Invadopodium membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027276119.1">
        <property type="nucleotide sequence ID" value="XM_027420318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JKS7"/>
    <dbReference type="GeneID" id="100767303"/>
    <dbReference type="KEGG" id="cge:100767303"/>
    <dbReference type="CTD" id="2191"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031258">
        <property type="term" value="C:lamellipodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.140.10.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF136">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE FAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="12">
        <location>
            <begin position="106"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="555"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276119.1"/>
        </source>
    </evidence>
    <sequence length="761" mass="87857" checksum="6B083E33A083D221" modified="2023-06-28" version="1">MKTWMKTVVGVATLAGLALLVICIVLRPSKVHIPERNTRRALNLKDILNGTFSYKTFFPNWISAQEYLHQSADDNIVFYNIETRESYVILSNSTMKSVNASDYGLSPDRQFAYLESDYSKLWRYSYTATYYIYDLRNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENKIFNGIPDWVYEEEMLAAKYALWWSPNGKFLAYAEFNDSEIPIIAYSYYGDGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPIEVPVPEMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWHAWSCPKTQEHIEESRTGWAGGFFVSTPAFSHDATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYDAKYYALICYGPGLPISTLHDGRTDQEIQILEENKELENALRNIQLPTEEIKKLEDSEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKPVFAVHWITYLASKEGIVVALVDGRGTAFQGDKFLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYTERFMGLPTKEDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSRGSTKHLYIHMTHFLKQCFSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JPN2</accession>
    <name>A0A9J7JPN2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase-activating protein 20 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC103163260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027268878.1">
        <property type="nucleotide sequence ID" value="XM_027413077.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JPN2"/>
    <dbReference type="GeneID" id="103163260"/>
    <dbReference type="KEGG" id="cge:103163260"/>
    <dbReference type="OrthoDB" id="9558881at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13319">
        <property type="entry name" value="PH_RARhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04402">
        <property type="entry name" value="RhoGAP_ARHGAP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047886">
        <property type="entry name" value="ARHGAP20-like_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047887">
        <property type="entry name" value="ARHGAP20_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF37">
        <property type="entry name" value="1700006A11RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22286">
        <property type="entry name" value="RHG20_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="321"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027268878.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="66691" checksum="0B99F723F935FC5F" modified="2023-06-28" version="1">MDKVASHPLHEEGTQCLTCHRRSLFTEMEILNGKVTDSEIKNQTLRLHGAVELRRGCISKKCHLYLYRDFLVVTNSWYKITFKIKYIIPLTSLWIGDGVVTDYVGPNQAKKSIFLGWPMENFIATFRSVGQKRDWCCFLGRSIKQTKEKYHGMSTALEIFTDGILSSNSAFTVTATHLDTVNDIIRKLQPLLGIPNAEEDYQLWFSSGQEETPCPLLGHENPYAIKMNELRNDAFMALGPSNYSAYLNIQNVIQELQDPHVPGKFIIKPKEPPRDNQQSNSEKTVRRFSLLSRIFHRGASTCQDCACYHTAAPTHGRLFNNPLGAICQDGNLPTSILDMLSLLEEIGPAVEGIFRKAGSITECQDVKEKLDLGEEVNLREESILVVSSVLKDFLRNIPGGVFSSSLYDKWMAVTDQDNEKERISSIQSLLEQLPTPNVVLLRQLFQVLHSIERHSSTNYMTSYNLSVCIAPSVLCLPNSSMLEFRKEIEKQISLVQFFIDNFEKIFEDNTNTHLGESSVIPSNGEETLDTFIGLCETDAAQDDERSCDSEQTHPKDGAEPQCPSAAPHEAVSVEQPLDPRPLNAQCSTEGTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JS70</accession>
    <name>A0A9J7JS70_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein 844-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC103160503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027272706.2">
        <property type="nucleotide sequence ID" value="XM_027416905.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027291956.2">
        <property type="nucleotide sequence ID" value="XM_027436155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JS70"/>
    <dbReference type="GeneID" id="103160503"/>
    <dbReference type="KEGG" id="cge:103160503"/>
    <dbReference type="OrthoDB" id="9623390at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039938">
        <property type="entry name" value="Sp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14947:SF26">
        <property type="entry name" value="RIKEN CDNA D130040H23 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14947">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_027272706.2"/>
        </source>
    </evidence>
    <sequence length="246" mass="28836" checksum="F000B2B1352706D0" modified="2023-06-28" version="1">MKRILMNAINEIKPLYVPVIFKYKKEVILERNPMDVINVVKPLPIKAFFKYIKEFILERNSVAVITVVKPLHIKVIFNYMKELILERNPMDVITVVKPLYAKVIFKDMQEFILERNLMNVINVVKPLHRTVIFKNMKEVTVERNLMNVVNVVKPLHITVIFTGMKEFILERNPMNVVNVVKLLHVTVIFTGMKEVILERNPMNVINVVKSLHTNVIFRGMKEVILDRHPVDIINVVETFHVTITFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JU19</accession>
    <name>A0A9J7JU19_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxygen-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC113833778</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via the doublecortin domains) with microtubules. Interacts with RP1L1. Interacts with MAK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035294907.1">
        <property type="nucleotide sequence ID" value="XM_035439016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113833778"/>
    <dbReference type="KEGG" id="cge:113833778"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042461">
        <property type="term" value="P:photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17147">
        <property type="entry name" value="DCX2_RP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000006">
        <property type="entry name" value="Oxygen-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000007">
        <property type="entry name" value="Oxygen-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23005:SF4">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23005">
        <property type="entry name" value="RETINITIS PIGMENTOSA 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0844">Vision</keyword>
    <feature type="domain" description="Doublecortin" evidence="15">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="15">
        <location>
            <begin position="157"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1412"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1570"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1424"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1570"/>
            <end position="1583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035294907.1"/>
        </source>
    </evidence>
    <sequence length="2123" mass="238507" checksum="3A0180E5FBDAE54C" modified="2023-06-28" version="1">MSETPSTRFSMIHLTSSEGQVPSPRANITHPVVAKRISFYKSGDPQFGGVKVVVNPRSFKTFDALLDNLSRKVPLPFGVRNISTPRGRHSITRLEELEDGESYLCSHNRKVLPVDLDKARRRPRPWLSSRSISTHVHLSSAAASVPTTAPGMLRAPRRLVVFRNGDPKTRRVVLLNRRVTQTFETFLQYLTQVMQCPVAKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPARLPGISHRVYRKGKPVLEKRKMSTHMPSVLSPQIESLASEKTYDCYSECSVAPENYLALEKHDSHNLSTYPDDGVEKSIIFNQDGTMTVVMKVRFKIKEEETVKWTTTVNRAGLSNNDEKNKKSSYPARSDDRPSSLKLTSCSLSEDITDTTQQGSLTEEENTQATAQQAESCSSAVWGNASVDTDIIQGCQKQVKHFYRPPTPGPKRRRQKKSVIGTVTVVSETEVQEKQFSYSEERESGEKSEYHMFTHSCSKMSSVSNKLVQIHSNDELESTLERTKETGLLKSNAINAGAIEITSQKVLKLCHNNGLPSSVSENSVVEEGIVESVVSDKDSIKHFRTYSNTNDKFSSVSADRTLSSGDNWGTDNSISEVPSVESSTVTTRVDRLLNEFSHCGLRELRENRKHGLSSFPSKKKKKSLQQMINSRYKKKVIETKGTSNKVGKINREGMITQGTLSQAPDSPLKGGKPCEECLDTNNFPPQSSLNIKISKNFHKNKLNAFQNPKTQKLLVKRKSRPVKVVSLEGLRKQEIGQGDKVFLHSESNIYKGNLENQSLLNVFNILKENQKVFHRPQSEVEVVTGNLRGVTKKSLVPKRNDLHVTLKNQKKQKVDKLKSGAIVSEQHDTTRADLLASLKKPDFSEGIPHYSVKNYVQRWLQNINQYQDFEHRKSAPLSKNGSNVVNYNSNGFPGSNLHTTSSKRNSFVMESNKHKTKNDTKNQETDKSFIAKDNGMLNKHVCESQDGSLHDSYLVSLRDHCTLSPATINDHSTKSHLSTEKSKSEVSLIYQEMNLATKGQSIEAAIQVDTIGENVPKNCLPALLLQHLEAFVPSNHKNQNGIAQIPGSLADVAFPSTVYNSSTNLLLAWLLVLNLKGNINSFCQSDAHKITSRSAETVALLEVLKHIAITEKADDLKAAVANLVESTKNCGEPSKREQDTVSANCTAASIQSVVKCNESERTQKMLLDEGYSTREDCGSELCVSEMIDKVHNSPHEMCTVNMANSPEDTGNPSNGFFTSNSYTISQPFTNGSILGGTCLLTDGVYSHNACSQKGNIYEAACSSDETYIPTRVCKSTDFVNSKENKCSDNLELTEELKTVNEVPKDLNSLADPMYKNDSNVSMSSQNVSNLSSHSLFLNKTDPEFDKDYSSLEEFKKCSLKKIVDKKKYISFDKEESRTSEEPGSITNSMTSSERNNISELESFEELESQDTDIFKIKVGAKEQPKEESMQKELEARMSLKSLHPSRRNIMEEEKRNTVILETIGRGQVTPPSLDFCYDSYKNTEKKISVGETKVRVKMMVESMENINHTESKKYLRSPVTLDWSGCRPDDKSGHPCKISNDDHNENDDTSQEKEYNRGIVKRAIEKLYGKAEIIKPPFFHGSIHRSQVCPYNPVELQCVKKTNFYDSECQSLVSSEQVSRSSLMFQESQEEGDGDVNGVRDSLGDNTIEHVTKPVEHDKDLMEKEKGELIDNGKWLLRENHLCRVSPDNPGMYGNADTTSVDTLIDKNSTGVPYSHFGDLAPGPTMAELSSSELEEMTQPLEVKCNYFNFPHGSDSEPFCEDFLDVQNKAHPKERIPNHHKEEKGNCPSERVCTSVTQAFVPAGNKVHPVGNDAIKTQPLPRSNITHGALQEGDSLDKLYALCGQHCPILTVIFQPVNEEDRGFAYRKDSDIENSLGFHLWMKTYPFLLQSNKNMLKGESNNVSVSRRLTDNVIGDPFDQLYFKNMVELMAKRMKHKHINSLELEEEINLKEFQLYLKKRFSDSMHTSLLVVEDMNSITLNPRNWTNNLKNVDENNNLINRFQNSRTNPNQVVTENTSYQFPFELFGLAYLLDIWQVEKSLNIRNRNKLEIHYILDGEILFIWEEESLLNVVDIESINEQDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JY51</accession>
    <name>A0A9J7JY51_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: putative transmembrane protein INAFM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113837328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027286849.1">
        <property type="nucleotide sequence ID" value="XM_027431048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JY51"/>
    <dbReference type="GeneID" id="113837328"/>
    <dbReference type="KEGG" id="cge:113837328"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029162">
        <property type="entry name" value="InaF-motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN INAFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34929">
        <property type="entry name" value="ZGC:153157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15018">
        <property type="entry name" value="InaF-motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027286849.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="19546" checksum="3D8FA6ABF4FF0A0B" modified="2023-06-28" version="1">MRGSSCVGGGGESPGGGGGGPRGRWLRLAPVCAYFLCVSLAAVLLAVYYGLIWVPTRPPAGPADPLPSAPAAPCARAAPPAPPPAASCLPGASGGPRPQPGLPRSRRSRSRSRSRSSRPAPGATAETARRAPGSRLAPPRPIVACTGSPLCSTRPPLPRPRSRACRPPGAHPAPPGTHRASRVRGPWSRAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K218</accession>
    <name>A0A9J7K218_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100759978</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative pheromone receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027290283.1">
        <property type="nucleotide sequence ID" value="XM_027434482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K218"/>
    <dbReference type="GeneID" id="100759978"/>
    <dbReference type="KEGG" id="cge:100759978"/>
    <dbReference type="OrthoDB" id="9576884at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016503">
        <property type="term" value="F:pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000033">
        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027290283.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32685" checksum="0CDAA79351736103" modified="2023-06-28" version="1">MDFWNLAIGFIYLSQTTAGILGNFSLIFYYVILYWRENTLKPTDWILIHILTANALIILSTGVPQTMAVWGFKHFLNDFGCQLLLYIQGLGRSVSIGTTCLLSVFQALTISPRKSCWKHHKVKVEKITGYHVSLIWILFILIFPYSFVNSGSKNVTIKRDLGYYSIVVWDGIGPSLYAALVVCPEVFISVLLVWSSGSMIFILYRHKQRLQHIRSTHGSSRKSPESRVTQNILILGSTFLAFHTLSSILRGYIIFLYNHNWWLVNTNRIASLCFPSFLPFVLIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4L7</accession>
    <name>A0A9J7K4L7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 431-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC107978924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035295698.1">
        <property type="nucleotide sequence ID" value="XM_035439807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K4L7"/>
    <dbReference type="GeneID" id="107978924"/>
    <dbReference type="KEGG" id="cge:107978924"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="6">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035295698.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11191" checksum="12ADBE529B0FAE1C" modified="2023-06-28" version="1">MGAETYDDVHINFSQEEWALLGPFKKSVYKDVLLDTDGNLIDIGYSWEDHNIEENCQTSRRHRRGRYPTCTYWKKRWEDDSLRTHPSRERLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K761</accession>
    <name>A0A9J7K761_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cadherin-8 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Cdh8</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035298498.1">
        <property type="nucleotide sequence ID" value="XM_035442607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K761"/>
    <dbReference type="GeneID" id="100758353"/>
    <dbReference type="KEGG" id="cge:100758353"/>
    <dbReference type="CTD" id="1006"/>
    <dbReference type="OrthoDB" id="8188793at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000008">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000012">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000017">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000014">
        <property type="entry name" value="Cadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF273">
        <property type="entry name" value="CADHERIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="613"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="87"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="168"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="277"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="392"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="496"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035298498.1"/>
        </source>
    </evidence>
    <sequence length="799" mass="88199" checksum="058D12DC981CE0EF" modified="2023-06-28" version="1">MPERLAETIVALWTPLIILWITLPTCVYMAPMNQAYTLSTGSPLELGRQSEELRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFAAEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K7X6</accession>
    <name>A0A9J7K7X6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC113835286</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC113835286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035299514.1">
        <property type="nucleotide sequence ID" value="XM_035443623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K7X6"/>
    <dbReference type="GeneID" id="113835286"/>
    <dbReference type="KEGG" id="cge:113835286"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035299514.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="32906" checksum="BF7D95698FE37F5F" modified="2023-06-28" version="1">MLPHPGLLGPPPRGEVASQVPAALAWAEASAAPGHPRAGRPHPAACPRFPVPGEPDDGARPLWGNSTPHLDPDRGGGARVCGSVIPGRPWRLPGPSKTQGSWRSAQETLVVEPLPDSHASEGGLHIFESIQEAGPGTRVETPRGSPFLRSFWCGEGPCGMLQTSTRAYPTRDCKCGTLAVGVPTGESRSRKARGSLRRVPGPPLAVALATTLEGKSKSFSESGPQSPFRRRTHLAWPLFNLSTQLAGPELISSGPGTFTFCRPSYIRRVEPQGVLGRGALTLWGVNGGTPVPLPGWAAAASGWRGHCCFSTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KBS3</accession>
    <name>A0A9J7KBS3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear RNA export factor 5 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100770077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305605.1">
        <property type="nucleotide sequence ID" value="XM_035449714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KBS3"/>
    <dbReference type="GeneID" id="100770077"/>
    <dbReference type="KEGG" id="cge:100770077"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000004">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000384">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015245">
        <property type="entry name" value="Tap_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF45">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09162">
        <property type="entry name" value="Tap-RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="10">
        <location>
            <begin position="428"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035305605.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="76268" checksum="DD4F06143FA59961" modified="2023-06-28" version="1">MNSCVYYQLKGQDWNKPGQPPRSQASPRPRPSFCDWIDDHDAMTMSHPQASLIEQLYPGFYLEQNYEKIPFQEHEKDMGTSQESSSKESLYDGYYGDNLLLSQLQDNDGNIQIKYGYDYPQVLDSSTFPVQEDDGTCYAACQYINFSEDEWNDSIEDEAFEGWFKITIPNGRKYNKMWIINLLQSHCSVAFTPVDFQYIRNRIQFFVQNAQSAFELMNINFQIRDEENRKISICVCSSTGPASVQYKLTPGQMEILKRSMMKRYDVSRKSLSLKKLRFDPDLMDHGLDIFLNRRSCMAAMLQIIQVDFPELLSLNLSNNKICWLDGLSELIEKAPQVKILNLSKNVLRTAWELEKMKGLKLKELWLEGNPMCSTFADNSAYVSAVLNCFPELLCLDGFKLFPTVDTYTLAIIKPRQETYRGSESLKDLIVQFMLQYYLIYDYGDRRNLLTAYHAEACFSLTITSNSDKPNMRTLEEYFKDSRNMKKIKDSFLRMQLLKHKKCNIVTCLHELPKTQHDLTSCVVDICAQTEKMICFSVNGVFKEMEGTSKGCIRAFTRTFILTAGRHFSVNNRELGLRFNEAGRQSFKGYSYDRGNGYQLMKYGNRGGVCSSRLCIVNDEMILRNATAQETKKAFSTTMPTIVYAKGHQQMKDFPTWTDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KEI2</accession>
    <name>A0A9J7KEI2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Mindy4b</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035307473.1">
        <property type="nucleotide sequence ID" value="XM_035451582.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312044.1">
        <property type="nucleotide sequence ID" value="XM_035456153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KEI2"/>
    <dbReference type="GeneID" id="107977034"/>
    <dbReference type="KEGG" id="cge:107977034"/>
    <dbReference type="CTD" id="646951"/>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF18">
        <property type="entry name" value="INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="3">
        <location>
            <begin position="101"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035307473.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51960" checksum="6107286550705D2A" modified="2023-06-28" version="1">MDTEISVQEQSPLELDLNEITEKILFLDKWRGIFRYYRLGTNNTNPQDRDGSHVSAEETRDRSGMLWSKGSSSFCSIPKVSIISSKLNGFPISPAMATVLQRSLFGNTTHVLGSDWRKAHFKFHSPFSDLAFALQVEKGGAQSIQMAVQGTLIKYLLFSREEKDCNLHSLCNLSQREQEQALAAVLAGILWTAGATQKAVICFVNKDIHSTSILDYSSDNFIERLQLFEFSDKEATEKFIYDHLQCFKGEGSHGVILFLYSLVFSRTFERLQKDLDITTTHLLQARAGNILCRQAVINMILTGRASPNVFNGYEKGSSEETLHGVLTRSDIGYLQWGKDSSEHDRLSQVGSMLRTPTFPIWLCNINGNYSILFCTNRQLLSDWKMERVFDLHFYSGQPSQKKLVHLTIDTHSHHWERERHEDKYGSGRRFSPVEMAIRTKWREATVNWNGTSPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YIF5</accession>
    <name>B0YIF5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GLAST</name>
        <name evidence="20" type="synonym">Glast</name>
        <name evidence="20" type="synonym">Slc1a3</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2006-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji X.H."/>
                <person name="Chen Y.Y."/>
                <person name="Guo L.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2007" name="Acta Biochim. Biophys. Sin." volume="39" first="851" last="856">
            <title>Existence of an endogenous glutamate and aspartate transporter in Chinese hamster ovary cells.</title>
            <authorList>
                <person name="Ji X."/>
                <person name="Jin Y."/>
                <person name="Chen Y."/>
                <person name="Li C."/>
                <person name="Guo L."/>
            </authorList>
            <dbReference type="PubMed" id="17989876"/>
            <dbReference type="DOI" id="10.1111/j.1745-7270.2007.00354.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
            <authorList>
                <person name="Becker J."/>
                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
            </authorList>
            <dbReference type="PubMed" id="21945585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29990"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) + L-glutamate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-glutamate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="EF155647">
        <property type="protein sequence ID" value="ABO69571.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233651.1">
        <property type="nucleotide sequence ID" value="NM_001246722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YIF5"/>
    <dbReference type="GeneID" id="100689464"/>
    <dbReference type="KEGG" id="cge:100689464"/>
    <dbReference type="CTD" id="6507"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070779">
        <property type="term" value="P:D-aspartate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140009">
        <property type="term" value="P:L-aspartate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098712">
        <property type="term" value="P:L-glutamate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3860.10:FF:000002">
        <property type="entry name" value="Amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF24">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 17" id="KW-0769">Symport</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABO69571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="NP_001233651.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="59689" checksum="186E1EAF730D1974" modified="2008-04-08" version="1">MTKSNGEEPRMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIAGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLDTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIVIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNMFPPNLVEACFKQFKTSYEKRSFRVPIQTNETLLGAVINNVSEAMETLTRIREEMVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALRDFFDSLNEAIMRLVAVIMWYAPLGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNEPEKTVADSETKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3GTX1</accession>
    <name>G3GTX1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger and BTB domain-containing protein 44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">BTB/POZ domain-containing protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Zbtb44</name>
        <name evidence="16" type="ORF">I79_001111</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000023">
        <property type="protein sequence ID" value="EGV92963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003495889.1">
        <property type="nucleotide sequence ID" value="XM_003495841.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267537.1">
        <property type="nucleotide sequence ID" value="XM_027411736.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GTX1"/>
    <dbReference type="STRING" id="10029.G3GTX1"/>
    <dbReference type="PaxDb" id="10029-XP_007632811.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024969.1">
        <property type="protein sequence ID" value="ENSCGRP00001020725.1"/>
        <property type="gene ID" value="ENSCGRG00001019782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754935"/>
    <dbReference type="KEGG" id="cge:100754935"/>
    <dbReference type="CTD" id="29068"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153306"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18228">
        <property type="entry name" value="BTB_POZ_ZBTB44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000266">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000278">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24383:SF10">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24383">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="455"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV92963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027267537.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="68613" checksum="3747B68D8E94B6D7" modified="2011-11-16" version="1">MGVKTFTHSSSSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILWNTPNSQPEKGLDAGQENSSNCNFTSRDGSISPVSSECSVVDRTIPVCRESRRKRKSYIVMSPESPVKCSTQTSSPQVLNSSASYAENRNQPVDSSLAFPWTFPFGIDRRIQPEKSKQAENTRTLELPGPSEAGRRMADYVTCESTKTTLPLGTEEDVQVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPGSEPVQEDLLISPQSSSIGSVDEGVTEGLPTLQSTSSTNAHADDDDRLENVQYPYQLYIAPSTSSTERPSPNGPDRPFQCPTCGVRFTRVQNLKQHMLIHSGIKPFQCDRCGKKFTRAYSLKMHRLKHEGKRCFRCQICSATFTSFGEYKHHMRVSRHIIRKPRIYECKTCGAMFTNSGNLIVHLRSLNHEASELANYFQSSDFLVPDYLNQEQEETLVQYDLGEHTFESNSSVQMPVISQVSSTQNCESSFPLGSLGGLAEKEEEVQEQPKTSVHAEATQDDPPKSELSSITIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3GU84</accession>
    <name>G3GU84_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase/reductase 9</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5 9">Dehydrogenase/reductase SDR family member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Dhrs9</name>
        <name evidence="5" type="ORF">I79_001237</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
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            </authorList>
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    <reference evidence="6" key="6">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732038" evidence="4">
        <location>
            <begin position="24"/>
            <end position="322"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV95641.1"/>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSCGRP00001016450.1"/>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">CHO K1 cell line</strain>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="15" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <source>
            <strain evidence="15">17A/GY</strain>
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    <reference evidence="12" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
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    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
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    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000097">
        <property type="protein sequence ID" value="EGV92002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ERE80248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498056.1">
        <property type="nucleotide sequence ID" value="XM_003498008.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261903.1">
        <property type="nucleotide sequence ID" value="XM_027406102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H0Q5"/>
    <dbReference type="STRING" id="10029.G3H0Q5"/>
    <dbReference type="PaxDb" id="10029-XP_007635045.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012246.1">
        <property type="protein sequence ID" value="ENSCGRP00001008138.1"/>
        <property type="gene ID" value="ENSCGRG00001010471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769650"/>
    <dbReference type="KEGG" id="cge:100769650"/>
    <dbReference type="eggNOG" id="KOG4119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNTACIA"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV92002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ERE80248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027261903.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7891" checksum="E353F154EFD7A37A" modified="2011-11-16" version="1">MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKKDPLLIPVPASENPFWEKKFFCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3H131</accession>
    <name>G3H131_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase pellino homolog</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Peli1</name>
        <name evidence="6" type="ORF">I79_003854</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pellino family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JH000100">
        <property type="protein sequence ID" value="EGW01245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498153.1">
        <property type="nucleotide sequence ID" value="XM_003498105.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243858.1">
        <property type="nucleotide sequence ID" value="XM_027388057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H131"/>
    <dbReference type="SMR" id="G3H131"/>
    <dbReference type="STRING" id="10029.G3H131"/>
    <dbReference type="PaxDb" id="10029-XP_007632138.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028096.1">
        <property type="protein sequence ID" value="ENSCGRP00001023850.1"/>
        <property type="gene ID" value="ENSCGRG00001021958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754085"/>
    <dbReference type="KEGG" id="cge:100754085"/>
    <dbReference type="CTD" id="57162"/>
    <dbReference type="eggNOG" id="KOG3842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183050"/>
    <dbReference type="OMA" id="QIGRMPC"/>
    <dbReference type="OrthoDB" id="8801906at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060546">
        <property type="term" value="P:negative regulation of necroptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034141">
        <property type="term" value="P:positive regulation of toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034145">
        <property type="term" value="P:positive regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043331">
        <property type="term" value="P:response to dsRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042098">
        <property type="term" value="P:T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038886">
        <property type="entry name" value="Pellino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Pellino FHA" evidence="4">
        <location>
            <begin position="10"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="5">
        <location>
            <begin position="275"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGW01245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027243858.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46286" checksum="233318A45E7546F7" modified="2011-11-16" version="1">MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3H3I0</accession>
    <name>G3H3I0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Timm17a</name>
        <name evidence="14" type="ORF">I79_004827</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Mitochondrion inner membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000127">
        <property type="protein sequence ID" value="EGW02176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498907.1">
        <property type="nucleotide sequence ID" value="XM_003498859.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273324.1">
        <property type="nucleotide sequence ID" value="XM_027417523.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H3I0"/>
    <dbReference type="STRING" id="10029.G3H3I0"/>
    <dbReference type="PaxDb" id="10029-XP_007633932.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017328.1">
        <property type="protein sequence ID" value="ENSCGRP00001013091.1"/>
        <property type="gene ID" value="ENSCGRG00001014322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755745"/>
    <dbReference type="KEGG" id="cge:100755745"/>
    <dbReference type="CTD" id="10440"/>
    <dbReference type="eggNOG" id="KOG1652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017780"/>
    <dbReference type="OMA" id="IMFTRIS"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005678">
        <property type="entry name" value="Tim17"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00980">
        <property type="entry name" value="3a0801so1tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM17-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW02176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027273324.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18098" checksum="2FFBF6AA5B5628BD" modified="2011-11-16" version="1">MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAFKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQIRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFPNGPQFAEDHSQLPSSQLPSSPFGDYRQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3H691</accession>
    <name>G3H691_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 11">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21 22 23" type="primary">Acp5</name>
        <name evidence="17" type="ORF">I79_005845</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="9">May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007640443.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007640444.3"/>
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        <property type="nucleotide sequence ID" value="XM_007640445.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027411611.2"/>
    </dbReference>
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        <property type="glycosylation" value="1 site"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSCGRP00001021425.1"/>
        <property type="gene ID" value="ENSCGRG00001020275.1"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="411211at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ferric iron binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:superoxide anion generation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
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    <dbReference type="PANTHER" id="PTHR10161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732104" description="Tartrate-resistant acid phosphatase type 5" evidence="15">
        <location>
            <begin position="25"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
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    </feature>
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        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
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        <ligand>
            <name>Fe cation</name>
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    <feature type="binding site" evidence="12">
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        <ligand>
            <name>Fe cation</name>
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        <ligand>
            <name>Fe cation</name>
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        </location>
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            <end position="221"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027267412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027267414.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37076" checksum="180315BA47F66043" modified="2011-11-16" version="1">MDARTVLLGLQIMSLPLLAHCAAATPTLRFVAVGDWGGVPNAPFHTAREVANAKEIARTVQIMGADFIMSLGDNFYFTGVHDAKDKRFQETFEDVFSDRALRNIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLHFKIPRTNTTVAIFMLDTVMLCGNSDDFVSQQPKMPRDMGVARSQLSWLKKQLAAAKEDYILVAGHYPIWSIAEHGPTRCLVKHLQPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKVPNGYLRFHYGSEDSLGGFTYVEISSKEMSITYVEAAGKSLFKTSLPRRLRPLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G3H6C2</accession>
    <name>G3H6C2_CRIGR</name>
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        <recommendedName>
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        <alternativeName>
            <fullName evidence="13">Cytosolic inhibitor of Nrf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19 20 21 22 23 24 25" type="primary">Keap1</name>
        <name evidence="15" type="ORF">I79_005877</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19 20 21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19 20 21">17A/GY</strain>
            <tissue evidence="19 20 21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of CUL3, 2 molecules of KEAP1, and RBX1. Interacts with NFE2L2/NRF2; the interaction is direct. Forms a ternary complex with NFE2L2/NRF2 and PGAM5. Interacts with (phosphorylated) SQSTM1/p62; the interaction is direct and inactivates the BCR(KEAP1) complex by sequestering it in inclusion bodies, promoting its degradation. Interacts with NFE2L1. Interacts with BPTF and PTMA. Interacts with MAP1LC3B. Interacts indirectly with ENC1. Interacts with SESN1 and SESN2. Interacts with HSP90AA1 and HSP90AB1. Interacts with PGCKA1; this interaction prevents the ubiquitination of KEAP1 by TRIM25, thus protecting KEAP1 from degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KEAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000173">
        <property type="protein sequence ID" value="EGV96193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007638680.1">
        <property type="nucleotide sequence ID" value="XM_007640490.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267300.1">
        <property type="nucleotide sequence ID" value="XM_027411499.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267301.1">
        <property type="nucleotide sequence ID" value="XM_027411500.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267302.1">
        <property type="nucleotide sequence ID" value="XM_027411501.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267303.1">
        <property type="nucleotide sequence ID" value="XM_027411502.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267304.1">
        <property type="nucleotide sequence ID" value="XM_027411503.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267306.1">
        <property type="nucleotide sequence ID" value="XM_027411505.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299395.1">
        <property type="nucleotide sequence ID" value="XM_035443504.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309958.1">
        <property type="nucleotide sequence ID" value="XM_035454067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H6C2"/>
    <dbReference type="STRING" id="10029.G3H6C2"/>
    <dbReference type="PaxDb" id="10029-XP_007624291.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020386.1">
        <property type="protein sequence ID" value="ENSCGRP00001016142.1"/>
        <property type="gene ID" value="ENSCGRG00001016562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759410"/>
    <dbReference type="KEGG" id="cge:100759410"/>
    <dbReference type="CTD" id="9817"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159543"/>
    <dbReference type="OMA" id="TECLTEY"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016234">
        <property type="term" value="C:inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071353">
        <property type="term" value="P:cellular response to interleukin-4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902883">
        <property type="term" value="P:negative regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045604">
        <property type="term" value="P:regulation of epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18458">
        <property type="entry name" value="BACK_KLHL19_KEAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18248">
        <property type="entry name" value="BTB_POZ_KLHL19_KEAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000024">
        <property type="entry name" value="Kelch-like ECH-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047098">
        <property type="entry name" value="KEAP1_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030563">
        <property type="entry name" value="KEAP1_BTB_POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF162">
        <property type="entry name" value="KELCH-LIKE ECH-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0883">Thioether bond</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV96193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027267300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027267301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027267302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027267303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027267304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027267306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035299395.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="69557" checksum="EDDA7649C609C18B" modified="2011-11-16" version="1">MQPEPRPSGAPRSSQFLPLSSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQSVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSNALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLYNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQKCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3H6N0</accession>
    <name>G3H6N0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100774857</name>
        <name evidence="13" type="ORF">I79_005996</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000177">
        <property type="protein sequence ID" value="EGW05767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003499898.1">
        <property type="nucleotide sequence ID" value="XM_003499850.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274865.1">
        <property type="nucleotide sequence ID" value="XM_027419064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H6N0"/>
    <dbReference type="STRING" id="10029.G3H6N0"/>
    <dbReference type="PaxDb" id="10029-XP_007610517.1"/>
    <dbReference type="GeneID" id="100774857"/>
    <dbReference type="KEGG" id="cge:100774857"/>
    <dbReference type="eggNOG" id="ENOG502SHK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H6N0"/>
    <dbReference type="OrthoDB" id="9975554at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000385">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="40"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW05767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027274865.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34410" checksum="47864EFF37D8D285" modified="2011-11-16" version="1">MAINQTTLKEFILIGFSAYPHVQTFLFGVFFCLYILTLAGNLTIMGLTWVDRSLHTPMYLFLSALSFSETCYTLTIIPRMLVDLLNNDRHISVAGCGLQMCFFLGLGGTNCIILTLMGYDRFLAICNPLRYPLLMTNVACGQLVASAWAGGFLISLIETALIFRVSFCIPNLIRHFFCHMRAVVRLSCIDSDLTEFIVTLMSVSGLLGTFLLISLTYVFILSSVLKIPSAEGKQKAFSTCASHLTVVIIHFGFASIVYLKPEASGGDDTLIAVPYTVITPFLSPIIFSLRNKDMKAAFRKVMRKTIVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3H7E0</accession>
    <name>G3H7E0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2</fullName>
            <ecNumber evidence="4">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Myotubularin-related protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphatidylinositol-3-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 28 29" type="primary">Mtmr2</name>
        <name evidence="24" type="ORF">I79_006271</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27 28 29" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27 28 29">17A/GY</strain>
            <tissue evidence="27 28 29">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42328"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78934"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42329"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:45632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
            <dbReference type="ChEBI" id="CHEBI:85342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:45633"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:39019"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="EC" id="3.1.3.95"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:39020"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="4"/>
    <dbReference type="EMBL" id="JH000193">
        <property type="protein sequence ID" value="EGW00889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016829964.1">
        <property type="nucleotide sequence ID" value="XM_016974475.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270936.1">
        <property type="nucleotide sequence ID" value="XM_027415135.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270937.1">
        <property type="nucleotide sequence ID" value="XM_027415136.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270938.1">
        <property type="nucleotide sequence ID" value="XM_027415137.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310173.1">
        <property type="nucleotide sequence ID" value="XM_035454282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H7E0"/>
    <dbReference type="STRING" id="10029.G3H7E0"/>
    <dbReference type="PaxDb" id="10029-XP_007631643.1"/>
    <dbReference type="GeneID" id="100762316"/>
    <dbReference type="CTD" id="8898"/>
    <dbReference type="eggNOG" id="KOG4471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H7E0"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14590">
        <property type="entry name" value="PTP-MTMR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000038">
        <property type="entry name" value="Myotubularin 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF42">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="23">
        <location>
            <begin position="133"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="315"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="19">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="346"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045083"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045090"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045091"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045115"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00045161"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047181"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047214"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGW00889.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027270936.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027270937.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027270938.1"/>
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    <sequence length="572" mass="66021" checksum="A08DFB3BA62DB711" modified="2011-11-16" version="1">MEEPTLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKQAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAELQRKVEELQREISNRSTSSSERASSPAQCVTPVQTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3H9Q4</accession>
    <name>G3H9Q4_CRIGR</name>
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            <fullName evidence="14">BCL2/adenovirus E1B interacting protein 1</fullName>
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        <submittedName>
            <fullName evidence="13 17">Vesicle transport protein SEC20</fullName>
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    <gene>
        <name evidence="14 17" type="primary">Bnip1</name>
        <name evidence="13" type="ORF">I79_007134</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000236">
        <property type="protein sequence ID" value="EGW06155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003500870.1">
        <property type="nucleotide sequence ID" value="XM_003500822.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280984.1">
        <property type="nucleotide sequence ID" value="XM_027425183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H9Q4"/>
    <dbReference type="STRING" id="10029.G3H9Q4"/>
    <dbReference type="PaxDb" id="10029-XP_007628881.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001074.1">
        <property type="protein sequence ID" value="ENSCGRP00001001050.1"/>
        <property type="gene ID" value="ENSCGRG00001000805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770337"/>
    <dbReference type="KEGG" id="cge:100770337"/>
    <dbReference type="CTD" id="662"/>
    <dbReference type="eggNOG" id="ENOG502QUTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TEVDTHR"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048763">
        <property type="term" value="F:calcium-induced calcium release activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140208">
        <property type="term" value="P:apoptotic process in response to mitochondrial fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15865">
        <property type="entry name" value="SNARE_SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="134"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW06155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027280984.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26222" checksum="ADDCB920487F76AD" modified="2011-11-16" version="1">MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSELTELNTKVKEKFQQLRCRIQELEQSAREQDKESDKQLLLQEVENHKKQMLSNQTSWRKANLTCKIAIDNLEKAELMQGGDLLRQRKTTKESLAQTSSTITESLMGISRMMSQQVQQSEEAMQTLVSSSRTLLDANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3HCI0</accession>
    <name>G3HCI0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Perilipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Plin3</name>
        <name evidence="9" type="ORF">I79_008191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the perilipin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000282">
        <property type="protein sequence ID" value="EGV93717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003501800.1">
        <property type="nucleotide sequence ID" value="XM_003501752.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272665.1">
        <property type="nucleotide sequence ID" value="XM_027416864.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HCI0"/>
    <dbReference type="SMR" id="G3HCI0"/>
    <dbReference type="STRING" id="10029.G3HCI0"/>
    <dbReference type="PaxDb" id="10029-XP_007616195.1"/>
    <dbReference type="GeneID" id="100758170"/>
    <dbReference type="KEGG" id="cge:100758170"/>
    <dbReference type="CTD" id="10226"/>
    <dbReference type="eggNOG" id="ENOG502R7TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HCI0"/>
    <dbReference type="OMA" id="VMFRGIT"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.340:FF:000004">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.170">
        <property type="entry name" value="Perilipin, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF11">
        <property type="entry name" value="PERILIPIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV93717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027272665.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="47529" checksum="8705B4E8D7D45B90" modified="2011-11-16" version="1">MSSNGTDAPAEAQAAVEEPVPQPSVVDRMASLPLISSTCEMVSAAYTSTKDRYPHVRTVCDVAEKGVKTLTAAAVSGAQPILSKLEPQIASASEYAHRGLDRLQESLPILQQPTEKVLADTKELVSSTVSGAKEIVSSSVTSAKDTVATRVTGAVDVTRGAVQSTMDMTKSAVTSGVQSVLGSRVGQMVIGGVDSMLVKSEAWADNRLPLTDAELALIATSPEGSDLASLQQQRQERNYFVRLGSLSERLRNHAYEHSLGKLRSARQNAHEALQQLTHALSLMESVKQGMDQRLGEGQEKLHHMWLSWNQKKPQDAEKDAAKPEQVEARALSMLRDITQQLQSTCVALGASIQGLPGHIREQAQQARSQVEDLQATFSGIHSFQDLTAGVLAQTRERIARAREALDHTVEYVAQNTPVTWLVGPFAPGITEKPLEEEKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3HDN1</accession>
    <name>G3HDN1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leiomodin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cardiac leiomodin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Leiomodin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Lmod2</name>
        <name evidence="15" type="ORF">H671_1g2599</name>
        <name evidence="14" type="ORF">I79_008617</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation. Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus). May also interact with TPM2 (via N-terminus). Interacts with FLII.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Myofibril</location>
            <location evidence="7">Sarcomere</location>
            <location evidence="7">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000299">
        <property type="protein sequence ID" value="EGV91670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE665133">
        <property type="protein sequence ID" value="ERE89073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307285.1">
        <property type="nucleotide sequence ID" value="XM_035451394.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311568.1">
        <property type="nucleotide sequence ID" value="XM_035455677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HDN1"/>
    <dbReference type="STRING" id="10029.G3HDN1"/>
    <dbReference type="PaxDb" id="10029-XP_007636679.1"/>
    <dbReference type="GeneID" id="100761449"/>
    <dbReference type="KEGG" id="cge:100761449"/>
    <dbReference type="CTD" id="442721"/>
    <dbReference type="eggNOG" id="KOG3735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005865">
        <property type="term" value="C:striated muscle thin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000132">
        <property type="entry name" value="Leiomodin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF12">
        <property type="entry name" value="LEIOMODIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="475"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
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            <dbReference type="EMBL" id="EGV91670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE89073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035307285.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="67499" checksum="84A5174A264E789E" modified="2011-11-16" version="1">MSTFGYRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVGLRQKSLTEKTPTGNFSREALMAYWEKESQKLLEKERLGECGKVAEEDKEESEEELIFTESNSEVSEEVCTEEEEEGQEESQEEEEEEEEEEEEEEETTAEATKHINGTVNYNSINSDNSKPKTFKSQIENINLTNGGSSGGTQRRTESPAAIHPCGNPTVIEDALEKIKNNDPDTTEVNLNNIENITTQTLSRFAEALRENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRMQEQKQQEGYDGGATLRTKVWQRGTPGSSPYASPRQSPWSSPKVSKKVHTGRSRPPSPVAPPPPPPPPPLPPHMLPPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQRKKKGKKVKKQPNNILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIRQLRRIKLKNFLKRLFGKYETSLGKDSYVAISLGSLIHKSDGSIGPSVFLSPIDSQKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3HFH1</accession>
    <name>G3HFH1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein 1</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-keto acyl-CoA synthase ELOVL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ELOVL fatty acid elongase 1</fullName>
            <shortName evidence="11">ELOVL FA elongase 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Very long chain 3-ketoacyl-CoA synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Very long chain 3-oxoacyl-CoA synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Elovl1</name>
        <name evidence="11" type="synonym">ELOVL1</name>
        <name evidence="13" type="ORF">I79_009311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with LASS2, TECR and HSD17B12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C-terminal di-lysine motif may confer endoplasmic reticulum localization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family. ELOVL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="EMBL" id="JH000327">
        <property type="protein sequence ID" value="EGW08122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502697.2">
        <property type="nucleotide sequence ID" value="XM_003502649.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254850.1">
        <property type="nucleotide sequence ID" value="XM_027399049.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HFH1"/>
    <dbReference type="STRING" id="10029.G3HFH1"/>
    <dbReference type="PaxDb" id="10029-XP_007617371.1"/>
    <dbReference type="GeneID" id="100767465"/>
    <dbReference type="KEGG" id="cge:100767465"/>
    <dbReference type="CTD" id="64834"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HFH1"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03201">
        <property type="entry name" value="VLCF_elongase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033681">
        <property type="entry name" value="ELOVL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF19">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 11 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Di-lysine motif" evidence="11">
        <location>
            <begin position="309"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW08122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027254850.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36354" checksum="61C0EF099BC4A1AF" modified="2011-11-16" version="1">MRKWPAGGPGDFSLALIPPNPPLLPAWFPLSLARMEAVTNLYQELMKHADPRIQNYPLMGSPLLITSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVTLSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFMLSKVIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGIKIAPGGMGSFHAMINSSVHVVMYLYYGLSALGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMPSCNYQYPVIIHLIWMYGTIFFVLFSNFWYHSYTKGKRLPRAVQQNGTPAITKVKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3HGW3</accession>
    <name>G3HGW3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13 14 15 16" type="primary">Osbpl2</name>
        <name evidence="9" type="ORF">I79_009855</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14 15">17A/GY</strain>
            <tissue evidence="13 14 15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000364">
        <property type="protein sequence ID" value="EGW11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003503158.1">
        <property type="nucleotide sequence ID" value="XM_003503110.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641930.1">
        <property type="nucleotide sequence ID" value="XM_007643740.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275681.1">
        <property type="nucleotide sequence ID" value="XM_027419880.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275683.1">
        <property type="nucleotide sequence ID" value="XM_027419882.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275684.1">
        <property type="nucleotide sequence ID" value="XM_027419883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275685.1">
        <property type="nucleotide sequence ID" value="XM_027419884.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027292860.1">
        <property type="nucleotide sequence ID" value="XM_027437059.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312213.1">
        <property type="nucleotide sequence ID" value="XM_035456322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HGW3"/>
    <dbReference type="STRING" id="10029.G3HGW3"/>
    <dbReference type="PaxDb" id="10029-XP_007613091.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006326.1">
        <property type="protein sequence ID" value="ENSCGRP00001004246.1"/>
        <property type="gene ID" value="ENSCGRG00001005341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754515"/>
    <dbReference type="KEGG" id="cge:100754515"/>
    <dbReference type="CTD" id="9885"/>
    <dbReference type="eggNOG" id="KOG2209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158762"/>
    <dbReference type="OMA" id="MSEPLQY"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010807">
        <property type="term" value="P:regulation of synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000005">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF153">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027275681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027275683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027275684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027275685.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55509" checksum="6A7F76EFF6AFB4AE" modified="2011-11-16" version="1">MNGEEEFFDAVTGFDSDNSTGEFSEANKVSGMIDFDTSKSTRSGRSGERPPQENGVQKHRTALPAPMFTRSDFSVWSILKKCIGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHKAASETQALERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFYSEGLNQDFMFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQLWIEQYGIVEILNHRTGDKCILHFKPCGLFGKELHRVEGYIQDRNRKKLFIIYGKWTECLWGIDPVSYESFKKHERRGDHPRKAKMDDSPEKANSDVPGDMTDDVPVAQETVQVIPGSKLLWRINSRPPNSAQMYNFTSFTVSLNELESGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARKERAKEEAEWRTRWFYPGTNPYTGAPDWLYAGDYFERNFSDCPDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3HQ15</accession>
    <name>G3HQ15_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Mat1a</name>
        <name evidence="16" type="ORF">I79_012904</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JH000595">
        <property type="protein sequence ID" value="EGV95145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307999.1">
        <property type="nucleotide sequence ID" value="XM_035452108.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313774.1">
        <property type="nucleotide sequence ID" value="XM_035457883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HQ15"/>
    <dbReference type="STRING" id="10029.G3HQ15"/>
    <dbReference type="PaxDb" id="10029-XP_007618349.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023372.1">
        <property type="protein sequence ID" value="ENSCGRP00001019128.1"/>
        <property type="gene ID" value="ENSCGRG00001018656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758089"/>
    <dbReference type="KEGG" id="cge:100758089"/>
    <dbReference type="CTD" id="4143"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183185"/>
    <dbReference type="OMA" id="DGLCDHT"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009087">
        <property type="term" value="P:L-methionine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="131"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="253"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV95145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035307999.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="43654" checksum="7FC8F320B7D22751" modified="2011-11-16" version="1">MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMREALKEQVIKAVVPDKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRNEFPWEVPKKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3HQ17</accession>
    <name>G3HQ17_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxiredoxin-like 2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Redox-regulatory protein FAM213A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Prxl2a</name>
        <name evidence="11" type="ORF">I79_012906</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000595">
        <property type="protein sequence ID" value="EGV95147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505709.1">
        <property type="nucleotide sequence ID" value="XM_003505661.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245215.1">
        <property type="nucleotide sequence ID" value="XM_027389414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HQ17"/>
    <dbReference type="STRING" id="10029.G3HQ17"/>
    <dbReference type="PaxDb" id="10029-XP_007618356.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008177.1">
        <property type="protein sequence ID" value="ENSCGRP00001005325.1"/>
        <property type="gene ID" value="ENSCGRG00001006989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759727"/>
    <dbReference type="KEGG" id="cge:100759727"/>
    <dbReference type="CTD" id="84293"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SMGMWSL"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045670">
        <property type="term" value="P:regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000312">
        <property type="entry name" value="redox-regulatory protein FAM213A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF31">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV95147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027245215.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25573" checksum="676E5544C4B22170" modified="2011-11-16" version="1">MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDIFLSKPRKAELEYLEDIDLKTLEKEPRTFKAKELWAKNGAVIMAVRRPGCFLCRAEAAELSSLKPKLDELGVPLYAVVKEQIKAEVKNFQPYFKGEIFLDEKKKFYGPERRKMMLMGLIRLGVWYNSFRAWKAGFSGNLEGEGFILGGVFVIGSGKQGILLEHREKEFGDKVNPLSVLEAVKKIKPQTPASGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3HSR8</accession>
    <name>G3HSR8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fin bud initiation factor homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Fibin</name>
        <name evidence="14" type="ORF">I79_013912</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homodimer; disulfide-linked. Seems to also exist as monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FIBIN family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000671">
        <property type="protein sequence ID" value="EGW07908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506556.1">
        <property type="nucleotide sequence ID" value="XM_003506508.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278089.1">
        <property type="nucleotide sequence ID" value="XM_027422288.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HSR8"/>
    <dbReference type="STRING" id="10029.G3HSR8"/>
    <dbReference type="PaxDb" id="10029-XP_007625952.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005266.1">
        <property type="protein sequence ID" value="ENSCGRP00001003621.1"/>
        <property type="gene ID" value="ENSCGRG00001004439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760017"/>
    <dbReference type="KEGG" id="cge:100760017"/>
    <dbReference type="CTD" id="387758"/>
    <dbReference type="eggNOG" id="ENOG502QSW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007623"/>
    <dbReference type="OMA" id="CHGYFDG"/>
    <dbReference type="OrthoDB" id="9434858at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026772">
        <property type="entry name" value="Fibin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31185">
        <property type="entry name" value="FIN BUD INITIATION FACTOR FIBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31185:SF0">
        <property type="entry name" value="FIN BUD INITIATION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15819">
        <property type="entry name" value="Fibin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="14 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732247" description="Fin bud initiation factor homolog" evidence="13">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW07908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027278089.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24658" checksum="FB50976B49EDA896" modified="2011-11-16" version="1">MVIPKLIWMGFFCHLCRGYFDGPLYPEMSNGTLHHYFVPDGDYEENDDPEKCQLLFRVSDRRRCSQGEGGQASSLLSLTLREEFTVLGRQVEDAGRVLEGISKSISYDLDGEESYGKYLRRESHQIGDAYSNSDKSLTELESKFKQGQEQDSRQESRLNEDFLGMLVHTRSLLKETLDISVGLRDKYELLALTIRSHGTRLGRLKSGYLEGGGQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3HYR7</accession>
    <name>G3HYR7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Abscission/NoCut checkpoint regulator</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Zinc finger FYVE domain-containing protein 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Zfyve19</name>
        <name evidence="23" type="ORF">I79_016208</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts (via MIM1-B) with VPS4A; interaction takes place at the midbody ring following cytokinesis checkpoint activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
            <location evidence="2">Midbody ring</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000944">
        <property type="protein sequence ID" value="EGW09307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003508361.1">
        <property type="nucleotide sequence ID" value="XM_003508313.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277976.1">
        <property type="nucleotide sequence ID" value="XM_027422175.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HYR7"/>
    <dbReference type="STRING" id="10029.G3HYR7"/>
    <dbReference type="PaxDb" id="10029-XP_007617166.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018972.1">
        <property type="protein sequence ID" value="ENSCGRP00001014734.1"/>
        <property type="gene ID" value="ENSCGRG00001015536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751587"/>
    <dbReference type="KEGG" id="cge:100751587"/>
    <dbReference type="CTD" id="84936"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016108"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15749">
        <property type="entry name" value="FYVE_ZFY19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger FYVE-type containing 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
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        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
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    </dbReference>
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        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="22">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004476"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064127"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083264"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
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    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
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    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGW09307.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014734.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027277976.1"/>
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    </evidence>
    <sequence length="397" mass="44177" checksum="C619B2F0A005E702" modified="2011-11-16" version="1">MESRCYGCAVKFTLFKKEYGCKNCGRAFCSGCLSFNALVPRAGNTQQKVCKQCHTVLTRGPPDNTSKWSPPQNYKKRVAALEAKKKPSISQSQGLTQQDQAIADRLARLRQENKPKSVPSQAEIEARLAALKDEVQGAIPSTREMEDRLAALQGRVPPSHTVRPAHQAPDTRTQAQQTQDLLTQLAAEVAIDESWERRAPVAPLQNDLNKGGTRNQHTNSQGQASPSLEKEKSRLLAEAAIELREENTRQERILALAKRLAILQGQDPNRVTLQDYHLPDSDEEDEETAIQRVLQQLTEEAALDEASGFNIPVEPAPRPRAQSCRAETKTQSLLPGPQAAEEELPWCCICNEDAVLRCAGCDGDLYCARCFREGHDNFDLKEHQTSAYRPRPPGREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3I0I6</accession>
    <name>G3I0I6_CRIGR</name>
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        <recommendedName>
            <fullName evidence="8">Interferon epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Interferon epsilon-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Ifne</name>
        <name evidence="12" type="ORF">I79_016871</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the alpha/beta interferon family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001015">
        <property type="protein sequence ID" value="EGV95214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003508875.1">
        <property type="nucleotide sequence ID" value="XM_003508827.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256150.1">
        <property type="nucleotide sequence ID" value="XM_027400349.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I0I6"/>
    <dbReference type="STRING" id="10029.G3I0I6"/>
    <dbReference type="PaxDb" id="10029-XP_007616841.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007828.1">
        <property type="protein sequence ID" value="ENSCGRP00001005126.1"/>
        <property type="gene ID" value="ENSCGRG00001006683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761194"/>
    <dbReference type="KEGG" id="cge:100761194"/>
    <dbReference type="CTD" id="338376"/>
    <dbReference type="eggNOG" id="ENOG502S65R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214430"/>
    <dbReference type="OMA" id="QQCLPHR"/>
    <dbReference type="OrthoDB" id="8922121at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000033">
        <property type="entry name" value="Interferon epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000471">
        <property type="entry name" value="Interferon_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691:SF8">
        <property type="entry name" value="INTERFERON EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691">
        <property type="entry name" value="TYPE I INTERFERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00143">
        <property type="entry name" value="Interferon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00266">
        <property type="entry name" value="INTERFERONAB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00076">
        <property type="entry name" value="IFabd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00252">
        <property type="entry name" value="INTERFERON_A_B_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3 10" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732303" description="Interferon epsilon" evidence="11">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV95214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027256150.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22498" checksum="14E2B9AEBC08C31C" modified="2011-11-16" version="1">MIHKQLPEMVLLLLASSTVFSLEPKSILFQSRMKRESLHLLKTLPISSVYQCLAHRKNFQLPWQSVSRHQYQKGHVLAVLHELLQQIFSLFQAHVSRGIWEENHIERVLGALHQQLEYVELLAGLKAESKSGGLSAQSLRLQIKSYFRRIHDYLENQRYSSCAWIVVQVEINRCMFFVFRLTAWLNKQETDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3I3A5</accession>
    <name>G3I3A5_CRIGR</name>
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        <submittedName>
            <fullName evidence="14">Mitochondrial carrier triple repeat protein 6</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Solute carrier family 25 member 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Slc25a53</name>
        <name evidence="14" type="ORF">I79_017907</name>
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    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035460638.1"/>
    </dbReference>
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    <dbReference type="STRING" id="10029.G3I3A5"/>
    <dbReference type="PaxDb" id="10029-XP_007610658.1"/>
    <dbReference type="GeneID" id="100756176"/>
    <dbReference type="KEGG" id="cge:100756176"/>
    <dbReference type="CTD" id="401612"/>
    <dbReference type="eggNOG" id="KOG1519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I3A5"/>
    <dbReference type="OMA" id="LGYYRAF"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF5">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW03311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035305778.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34492" checksum="AF7FCB4C23D5803A" modified="2011-11-16" version="1">MDEQNNSSGKELQQRTRAEVPGKKSWHSQAYTLGAISNFMSTFLTFPIYKVVFRQQIHAMAVSEAVRQLWHEGPQYFYRGIYPPLLSKTLQGTLLFGTYDSLLCFLSPVGPHSLGQRWTAGLMSGVVEAVALSPFERVQNVLQDARKQASFPSTFSILKEFNSYGLWGRLSLGYYRGFWPVLVRNSLGSALYFSFKDPIQDGLARQGLPHWVPALVSGSVNGTITCLVLYPLIVLVANMQSHIGWQRMPSLWASAQDVWDTRGRKILLIYRGGSLIVLRSSVTWGLTTAIHDFLQRKAHSKKEMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3I4J0</accession>
    <name>G3I4J0_CRIGR</name>
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        <submittedName>
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        <submittedName>
            <fullName evidence="2">PAXIP1-associated protein 1</fullName>
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    <gene>
        <name evidence="3 6" type="primary">Pagr1</name>
        <name evidence="2" type="ORF">I79_018370</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH001251">
        <property type="protein sequence ID" value="EGW09881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510168.1">
        <property type="nucleotide sequence ID" value="XM_003510120.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260393.1">
        <property type="nucleotide sequence ID" value="XM_027404592.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I4J0"/>
    <dbReference type="STRING" id="10029.G3I4J0"/>
    <dbReference type="PaxDb" id="10029-XP_007612412.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022326.1">
        <property type="protein sequence ID" value="ENSCGRP00001018082.1"/>
        <property type="gene ID" value="ENSCGRG00001017938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751387"/>
    <dbReference type="KEGG" id="cge:100751387"/>
    <dbReference type="CTD" id="79447"/>
    <dbReference type="eggNOG" id="ENOG502S0T8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067843at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902808">
        <property type="term" value="P:positive regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033148">
        <property type="term" value="P:positive regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028213">
        <property type="entry name" value="PA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28467">
        <property type="entry name" value="PAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28467:SF1">
        <property type="entry name" value="PAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15364">
        <property type="entry name" value="PAXIP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW09881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027260393.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27497" checksum="BD50ADA73EC7EBE0" modified="2011-11-16" version="1">MSLGHGTIAGSTTAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGQGGREEAGREGSRAEEALEAPNAAGDERAEGESEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLAAQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPMTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSESPSPASPPLRSSGSSLFPRQRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3I5I4</accession>
    <name>G3I5I4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19 22 23 24">Zinc finger protein 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 22 23 24 25 26 27 28 29 30 31 32 33 34" type="primary">Zfp41</name>
        <name evidence="18" type="ORF">I79_018732</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23 24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23 24">17A/GY</strain>
            <tissue evidence="22 23 24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001301">
        <property type="protein sequence ID" value="EGW11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510487.1">
        <property type="nucleotide sequence ID" value="XM_003510439.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016835167.1">
        <property type="nucleotide sequence ID" value="XM_016979678.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259635.1">
        <property type="nucleotide sequence ID" value="XM_027403834.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259636.1">
        <property type="nucleotide sequence ID" value="XM_027403835.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259637.1">
        <property type="nucleotide sequence ID" value="XM_027403836.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259638.1">
        <property type="nucleotide sequence ID" value="XM_027403837.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259639.1">
        <property type="nucleotide sequence ID" value="XM_027403838.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259640.1">
        <property type="nucleotide sequence ID" value="XM_027403839.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259641.1">
        <property type="nucleotide sequence ID" value="XM_027403840.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259642.1">
        <property type="nucleotide sequence ID" value="XM_027403841.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259643.1">
        <property type="nucleotide sequence ID" value="XM_027403842.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259644.1">
        <property type="nucleotide sequence ID" value="XM_027403843.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259645.1">
        <property type="nucleotide sequence ID" value="XM_027403844.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297930.1">
        <property type="nucleotide sequence ID" value="XM_027442129.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297931.1">
        <property type="nucleotide sequence ID" value="XM_027442130.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297932.1">
        <property type="nucleotide sequence ID" value="XM_027442131.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297933.1">
        <property type="nucleotide sequence ID" value="XM_027442132.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297934.1">
        <property type="nucleotide sequence ID" value="XM_027442133.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297935.1">
        <property type="nucleotide sequence ID" value="XM_027442134.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297936.1">
        <property type="nucleotide sequence ID" value="XM_027442135.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297937.1">
        <property type="nucleotide sequence ID" value="XM_027442136.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297938.1">
        <property type="nucleotide sequence ID" value="XM_027442137.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296564.1">
        <property type="nucleotide sequence ID" value="XM_035440673.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296565.1">
        <property type="nucleotide sequence ID" value="XM_035440674.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317086.1">
        <property type="nucleotide sequence ID" value="XM_035461195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317087.1">
        <property type="nucleotide sequence ID" value="XM_035461196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I5I4"/>
    <dbReference type="PaxDb" id="10029-XP_007614824.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010865.1">
        <property type="protein sequence ID" value="ENSCGRP00001006889.1"/>
        <property type="gene ID" value="ENSCGRG00001009367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757735"/>
    <dbReference type="KEGG" id="cge:100757735"/>
    <dbReference type="CTD" id="286128"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRKKPHE"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001451">
        <property type="entry name" value="zinc finger protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGW11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027259635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027259636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027259637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027259638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027259639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027259640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027259641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027259642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027259643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027259644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027259645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_035296564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="RefSeq" id="XP_035296565.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22795" checksum="7485D4101518F1FD" modified="2011-11-16" version="1">MEKPAGRKKKTQATKEEAAVQKTTVKGEKASKGKKPTKRSAKPRKPRKQTVLSPEDEAHIFDAFDASFKDDFEGVPVFVPFQRKKPYECSECGRIFKHKTDHIRHQRVHTGEKPFKCDQCGKTFRHSSDVTKHLRIHTGEKPFKCGECGKAFNCGSNLLKHQKMHTGEKPYGCEECGKYFAYSSCLIRHRKRHPRKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3IA23</accession>
    <name>G3IA23_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uridine phosphorylase</fullName>
            <ecNumber evidence="5">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Upp1</name>
        <name evidence="7" type="ORF">I79_020439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine + phosphate = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5"/>
    <dbReference type="EMBL" id="JH001664">
        <property type="protein sequence ID" value="EGW07226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292428.1">
        <property type="nucleotide sequence ID" value="XM_035436537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309089.1">
        <property type="nucleotide sequence ID" value="XM_035453198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IA23"/>
    <dbReference type="STRING" id="10029.G3IA23"/>
    <dbReference type="PaxDb" id="10029-XP_007637833.1"/>
    <dbReference type="GeneID" id="100752663"/>
    <dbReference type="CTD" id="7378"/>
    <dbReference type="eggNOG" id="KOG3728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3IA23"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF10">
        <property type="entry name" value="URIDINE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGW07226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035309089.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30949" checksum="B920209FE04D5540" modified="2011-11-16" version="1">MKEDVLYHFNLSTSTHDFPAMFGDVKFVCVGGSPSRMSTFIKYVAAELGLDHPGKEYPNICAGTDRYAMYKVGPVLSVSHGMGIPSIGIMLHELIKMLYHARCSNITIIRIGTSGGIGLEPGSVVITQQAVDECFKPEFEQIVLGKRVVRSTNLDVKLVQELMQCSSDLNEFPTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLQAAHAAGVRNIEMESSLFATMCSACGLRAAVVCVTLLDRLQGDQINTPHDVLVEYQQRPQRLVGHFIKKSLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3IEA2</accession>
    <name>G3IEA2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Zinc finger protein Krox-25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Znf22</name>
        <name evidence="18" type="ORF">I79_022046</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002160">
        <property type="protein sequence ID" value="EGW13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651649.1">
        <property type="nucleotide sequence ID" value="XM_007653459.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285020.1">
        <property type="nucleotide sequence ID" value="XM_027429219.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IEA2"/>
    <dbReference type="STRING" id="10029.G3IEA2"/>
    <dbReference type="PaxDb" id="10029-XP_007651650.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009638.1">
        <property type="protein sequence ID" value="ENSCGRP00001006165.1"/>
        <property type="gene ID" value="ENSCGRG00001008275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758901"/>
    <dbReference type="KEGG" id="cge:100758901"/>
    <dbReference type="CTD" id="7570"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WGVTVRF"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000644">
        <property type="entry name" value="Zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000670">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000817">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGW13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027285020.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27291" checksum="6F025D4A573CF8EF" modified="2011-11-16" version="1">MRLAKPKGGISRSSSQGKAYETKRKTARQRQKWGMTIRFDSGFSRRRRNVDEKPYKCSRCSKSFSQSSTLFQHQKIHTGKKSHKCADCGKSFFQSSNLIQHRRVHTGEKPYKCDECGESFKQSSNLIQHQRIHTGEKPYCCDECGRCFSQSSHLIQHQRTHTGEKPYQCDECDKCFSQSSHLRQHLKVHKEKKPHKRGKNARAKTHPVSWKVGKGRKAVSGRRQVKGAAAGLFKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3IHN4</accession>
    <name>G3IHN4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WD repeat-containing protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">Wdr74</name>
        <name evidence="12" type="ORF">H671_3g9641</name>
        <name evidence="11" type="ORF">I79_023330</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Isoform 1 interacts (through WDR repeats) with NVL; the interaction is independent of RNA or pre-60S ribosome particles. Isoform 2 does not interact with NVL. Interacts with MTREX; the interaction dissociation in a late stage of rRNA synthesis is required for appropriate maturation of pre-60S particles and depends on the ATPase activity of NVL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH002825">
        <property type="protein sequence ID" value="EGW04473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE672361">
        <property type="protein sequence ID" value="ERE79362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514224.1">
        <property type="nucleotide sequence ID" value="XM_003514176.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264171.1">
        <property type="nucleotide sequence ID" value="XM_027408370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IHN4"/>
    <dbReference type="STRING" id="10029.G3IHN4"/>
    <dbReference type="PaxDb" id="10029-XP_007608251.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005064.1">
        <property type="protein sequence ID" value="ENSCGRP00001003504.1"/>
        <property type="gene ID" value="ENSCGRG00001004246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754753"/>
    <dbReference type="KEGG" id="cge:100754753"/>
    <dbReference type="CTD" id="54663"/>
    <dbReference type="eggNOG" id="KOG3881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015119"/>
    <dbReference type="OMA" id="KNVCRMR"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001825">
        <property type="term" value="P:blastocyst formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22857">
        <property type="entry name" value="WDR74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000214">
        <property type="entry name" value="WD repeat-containing protein 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000287">
        <property type="entry name" value="WD repeat-containing protein 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW04473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ERE79362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027264171.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42667" checksum="018B2E49F8794D77" modified="2011-11-16" version="1">MAAASSRGNHVWVGTDTGILKGVNLQRRHATNFTPSGQPRREEAVNALCWRAGDETQILVGCADMTVRHFNTEEGTFQSQRHCPGGEGTFRGLAQADGTLITCVDSGILRVWCDNDKEASSDPLLELKVGPGVCRMRQDPAHSHVVATCGKENALKVWDLQKPEQPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRSPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNMVPPEDTETDELWASLEANAKRKLPDLNQIQGTLQTRKKKKRPGSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3ILP8</accession>
    <name>G3ILP8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Calcineurin B homologous protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">Calcineurin B-likeous protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">Calcineurin-like EF hand protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Chp2</name>
        <name evidence="18" type="ORF">I79_024819</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH004184">
        <property type="protein sequence ID" value="EGW15096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003515365.1">
        <property type="nucleotide sequence ID" value="XM_003515317.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266079.1">
        <property type="nucleotide sequence ID" value="XM_027410278.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ILP8"/>
    <dbReference type="STRING" id="10029.G3ILP8"/>
    <dbReference type="PaxDb" id="10029-XP_007615849.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021580.1">
        <property type="protein sequence ID" value="ENSCGRP00001017336.1"/>
        <property type="gene ID" value="ENSCGRG00001017404.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759970"/>
    <dbReference type="KEGG" id="cge:100759970"/>
    <dbReference type="CTD" id="63928"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKISEMF"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070886">
        <property type="term" value="P:positive regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000093">
        <property type="entry name" value="Calcineurin B homologous protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGW15096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027266079.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22456" checksum="D48B20C7E1E384BB" modified="2011-11-16" version="1">MGSRSSHAALIPDVDHIRRETGFSQASLLRLYHRFQALDREEKGYLSRLDLQQIGALAVNPLGDRIIDSFFPNGSQRVDFAGFARVLAHFRPVDEEDATIRDPKQPEPLNSRMNKLRFAFQLYDLDRDGKISRNEMLQVLRLMVGVQVTDEQLESITDRTVQEADEDGDGAVSFMEFTKSLEKMNIEQKMSIRILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HXZ1</accession>
    <name>A0A061HXZ1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Gamma-aminobutyric acid receptor subunit alpha-6 isoform 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="25">Gamma-aminobutyric acid receptor subunit alpha-6 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="22">Gamma-aminobutyric acid type A receptor subunit alpha 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Gabra6</name>
        <name evidence="21" type="ORF">H671_7g18368</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE682089">
        <property type="protein sequence ID" value="ERE67832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281037.1">
        <property type="nucleotide sequence ID" value="XM_027425236.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HXZ1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019171.1">
        <property type="protein sequence ID" value="ENSCGRP00001014933.1"/>
        <property type="gene ID" value="ENSCGRG00001015664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765459"/>
    <dbReference type="KEGG" id="cge:100765459"/>
    <dbReference type="CTD" id="2559"/>
    <dbReference type="GeneTree" id="ENSGT00940000156722"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099192">
        <property type="term" value="C:cerebellar Golgi cell to granule cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19052">
        <property type="entry name" value="LGIC_TM_GABAAR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000001">
        <property type="entry name" value="Gamma-aminobutyric acid A receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000002">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit alpha-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005436">
        <property type="entry name" value="GABBAa6_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047024">
        <property type="entry name" value="Gabra-1-6_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01619">
        <property type="entry name" value="GABAARALPHA6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
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        </location>
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            <begin position="240"/>
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        </location>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ERE67832.1"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014933.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027281037.1"/>
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    <sequence length="453" mass="51239" checksum="97D1E6B4D530B032" modified="2014-09-03" version="1">MVVLLSWLSIILWLENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFRGPAEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQRAERKAQTTAPPPVAISKATEPREAEIIVHSESKYHLKKRISSLTLPIVPSSEASKVLSRMPILQTTPVTPPPLLPAVGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE</sequence>
</entry>
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        <name type="scientific">Cricetulus griseus</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">17A/GY</strain>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">17A/GY</strain>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE672352">
        <property type="protein sequence ID" value="ERE79393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027409454.2"/>
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        <property type="term" value="F:nuclear localization sequence binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:RNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
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    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
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        <property type="entry name" value="POM121-LIKE PROTEIN 2"/>
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    </dbReference>
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        <property type="entry name" value="POM121"/>
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            <dbReference type="EMBL" id="ERE79393.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027265255.1"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A061IKL2</accession>
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            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
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    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acylcholine + H2O = a carboxylate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21964"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:35287"/>
            <dbReference type="EC" id="3.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; disulfide-linked. Dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KE664763">
        <property type="protein sequence ID" value="ERE89338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306406.1">
        <property type="nucleotide sequence ID" value="XM_035450515.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317103.1">
        <property type="nucleotide sequence ID" value="XM_035461212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IKL2"/>
    <dbReference type="ESTHER" id="crigr-a0a061ikl2">
        <property type="family name" value="BCHE"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.980"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010781.1">
        <property type="protein sequence ID" value="ENSCGRP00001006830.1"/>
        <property type="gene ID" value="ENSCGRG00001009291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767789"/>
    <dbReference type="KEGG" id="cge:100767789"/>
    <dbReference type="CTD" id="590"/>
    <dbReference type="GeneTree" id="ENSGT00940000157023"/>
    <dbReference type="OMA" id="YICPGID"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:choline metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014788">
        <property type="entry name" value="AChE_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
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    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
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        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF5">
        <property type="entry name" value="CHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08674">
        <property type="entry name" value="AChE_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044513431" description="Carboxylic ester hydrolase" evidence="13">
        <location>
            <begin position="30"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="14">
        <location>
            <begin position="33"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Acetylcholinesterase tetramerisation" evidence="15">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
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            <dbReference type="Ensembl" id="ENSCGRP00001006830.1"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IQX5</accession>
    <name>A0A061IQX5_CRIGR</name>
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        <alternativeName>
            <fullName evidence="19">ELOVL fatty acid elongase 6</fullName>
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        <alternativeName>
            <fullName evidence="19">Very long chain 3-ketoacyl-CoA synthase 6</fullName>
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        <alternativeName>
            <fullName evidence="19">Very long chain 3-oxoacyl-CoA synthase 6</fullName>
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    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="23">17A/GY</strain>
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    <reference evidence="21" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25 26">17A/GY</strain>
            <tissue evidence="25 26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:39675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:76555"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:39676"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74011"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:36512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36503"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:74012"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:36504"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:74034"/>
            <dbReference type="ChEBI" id="CHEBI:74054"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:36524"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:60140"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60141"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexadecanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctadecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35315"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:35316"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:39167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:39168"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="19">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="19">N-Glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ELO family. ELOVL6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="19"/>
    <dbReference type="EMBL" id="KE664252">
        <property type="protein sequence ID" value="ERE90156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251492.1">
        <property type="nucleotide sequence ID" value="XM_027395691.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251493.1">
        <property type="nucleotide sequence ID" value="XM_027395692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IQX5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020794.1">
        <property type="protein sequence ID" value="ENSCGRP00001016550.1"/>
        <property type="gene ID" value="ENSCGRG00001016844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763438"/>
    <dbReference type="KEGG" id="cge:100763438"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03206">
        <property type="entry name" value="VLCF_elongase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033675">
        <property type="entry name" value="ELOVL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF125">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 19 20" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 19 20" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 19 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 19 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ERE90156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027251492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027251493.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31630" checksum="664AEE4711EAF66E" modified="2014-09-03" version="1">MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQGFYIGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMMMGCVINYLVFNWMQHDNDQCYSHFLNIFWSSLMYLSYLVLFCHFFFEAYIGKMKKTTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IRB1</accession>
    <name>A0A061IRB1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thioredoxin-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Vitamin D3 up-regulated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Txnip</name>
        <name evidence="16" type="ORF">H671_1g1353</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts with DDIT4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE663761">
        <property type="protein sequence ID" value="ERE90892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498669.1">
        <property type="nucleotide sequence ID" value="XM_003498621.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249502.1">
        <property type="nucleotide sequence ID" value="XM_027393701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IRB1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011869.1">
        <property type="protein sequence ID" value="ENSCGRP00001007795.1"/>
        <property type="gene ID" value="ENSCGRG00001010170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756038"/>
    <dbReference type="KEGG" id="cge:100756038"/>
    <dbReference type="CTD" id="10628"/>
    <dbReference type="GeneTree" id="ENSGT00940000158522"/>
    <dbReference type="OMA" id="TKKYFEV"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071228">
        <property type="term" value="P:cellular response to tumor cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051782">
        <property type="term" value="P:negative regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000016">
        <property type="entry name" value="thioredoxin-interacting protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000017">
        <property type="entry name" value="thioredoxin-interacting protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF14">
        <property type="entry name" value="THIOREDOXIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="15">
        <location>
            <begin position="174"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ERE90892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027249502.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44611" checksum="21B08BCC0B66551A" modified="2014-09-03" version="1">MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRIKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIERKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCHILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDIIPEDHRLESPTTPLLDDMDGAQDSPIFMYAPEFQFMPPPTYTEVDPCTVNNNNNNNNNNNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7GMW3</accession>
    <name>A0A3L7GMW3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aryl-hydrocarbon-interacting protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Aipl1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be important in protein trafficking and/or protein folding and stabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with NUB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027281980.1">
        <property type="nucleotide sequence ID" value="XM_027426179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7GMW3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026336.1">
        <property type="protein sequence ID" value="ENSCGRP00001022091.1"/>
        <property type="gene ID" value="ENSCGRG00001020732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760409"/>
    <dbReference type="KEGG" id="cge:100760409"/>
    <dbReference type="CTD" id="23746"/>
    <dbReference type="GeneTree" id="ENSGT00390000001289"/>
    <dbReference type="OrthoDB" id="5829758at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001918">
        <property type="term" value="F:farnesylated protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007603">
        <property type="term" value="P:phototransduction, visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022400">
        <property type="term" value="P:regulation of opsin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001895">
        <property type="term" value="P:retina homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000018">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF2">
        <property type="entry name" value="ARYL-HYDROCARBON-INTERACTING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027281980.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="38105" checksum="01091288481F8900" modified="2019-02-13" version="1">MDVSLLLNVEGVKKTILHGGTGELPTFITGSRVTFHFRTMKCDAEHTVIDDSRQVGQPMSIIIGNMFKLEVWETLLTSMRLGEVAEYWCDTIHTGVYPMLSRSLRQVAEGKDPTGWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLIFLIELLQVEAPSEYQRETWNLNNEEKMQAVPLLHGEGNRLYKLGRYDQAATKYQEAIVCLRNLQTKEKPWDVEWLKLEKMINTLILNYCQCLLKREEYYEVLEHTSDILRHHPGIVKAYYVRARAHAEVWNAEEAKADLEKVLELEPSMRKAVLRELQQLESRLADKQEEERQRCRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7GVH9</accession>
    <name>A0A3L7GVH9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho guanine nucleotide exchange factor 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14 15" type="primary">Arhgef37</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15">17A/GY</strain>
            <tissue evidence="14 15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May act as a guanine nucleotide exchange factor (GEF).</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258592.1">
        <property type="nucleotide sequence ID" value="XM_027402791.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258594.1">
        <property type="nucleotide sequence ID" value="XM_027402793.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7GVH9"/>
    <dbReference type="SMR" id="A0A3L7GVH9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014144.1">
        <property type="protein sequence ID" value="ENSCGRP00001009925.1"/>
        <property type="gene ID" value="ENSCGRG00001011933.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756858"/>
    <dbReference type="KEGG" id="cge:100756858"/>
    <dbReference type="CTD" id="389337"/>
    <dbReference type="GeneTree" id="ENSGT00950000183088"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11799">
        <property type="entry name" value="SH3_ARHGEF37_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11941">
        <property type="entry name" value="SH3_ARHGEF37_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000177">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000057">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000029">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000174">
        <property type="entry name" value="rho guanine nucleotide exchange factor 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035636">
        <property type="entry name" value="ARHGEF37_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035823">
        <property type="entry name" value="ARHGEF37_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF9">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="30"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="254"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="506"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="603"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027258592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027258594.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="76333" checksum="E53A60EFF9FCEFA2" modified="2019-02-13" version="1">MADFGADEPSSRSESPEPEGRGSEDKSLLHQRLAIRELIDTEVSYLHMLRLCASDIRSRLQQLPPGDLDVLFSNIDDIIQVSGRFLQGLQETACREEEQVHLIGNLFLEFQEEFERVYKIYCANYDQALLLVKAYQKEPELQKSIQGIIEAAVPQAGPSGLSFLLVIPLQRITKYPLLLQKILENTPMDAIAHPVLQRATSALQDVNSNINEYKMRKEVALKYTKVEQLSLRERLARINTHTLSKKTTRLSQLLKQEAGLVPRTEDKEFDDLEERFQWVSLCVTELKSNMAAYMDNLEAFLCFRPHEWILDIPGGPAEQYCSLARDLQLEAFLKFKQRLEGLVWGPLCSLARALAGPQNLIKKRLDKLLDFERVEEKLLDVGSVTYEEEAARHTYQALNSLLVAELPQFNQLVTQWLGQILCTFVVLQKELADQVLRRAESSMALLPHQHVLEPDFQKLLEDTLVQNSGQLRSFQENFEKVLPPPTTQPLLPGSEYQLQALLTRYGPGKLYQVTSNISGAGTLDLTLPRGQIVALLQNKDTKGNNSRWLVDTGGHRGYVPAGKLQLYHHIVPSEKELRGQTGIHEDCWLSTPEPTQPSVPTVPTMTQVVAVYPFVARSTHELSLQAGQPVTILEAQDKKGNPEWSLVEVNGHRGYVPSNFLARTPSPTPWGWSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HK37</accession>
    <name>A0A3L7HK37_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family with sequence similarity 72, member A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Protein FAM72A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Fam72a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003501262.1">
        <property type="nucleotide sequence ID" value="XM_003501214.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273474.1">
        <property type="nucleotide sequence ID" value="XM_027417673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HK37"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027196.1">
        <property type="protein sequence ID" value="ENSCGRP00001022951.1"/>
        <property type="gene ID" value="ENSCGRG00001021328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757979"/>
    <dbReference type="KEGG" id="cge:100757979"/>
    <dbReference type="CTD" id="729533"/>
    <dbReference type="GeneTree" id="ENSGT00390000005106"/>
    <dbReference type="OMA" id="HLWIFNS"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
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        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027273474.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16681" checksum="543A192ADE01E0B3" modified="2019-02-13" version="1">MSANNCTFKDRCVSILCCKFCKQVLSCRGMKAVLLADTDIDLYSTDIPPTDTVDFIGRCYFTGICKCKLKDIACLKCGNIVGYHVIVPCSSCLLSCNNGHFWMFHSQAVYGINRLDSTGVNFLLWGNLPETEECTDEDVLEMSAEEYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HT64</accession>
    <name>A0A3L7HT64_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kelch-like protein 31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Kelch repeat and BTB domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Kelch-like protein KLHL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Klhl31</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035299367.1">
        <property type="nucleotide sequence ID" value="XM_035443476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HT64"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029138.1">
        <property type="protein sequence ID" value="ENSCGRP00001024892.1"/>
        <property type="gene ID" value="ENSCGRG00001022670.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752315"/>
    <dbReference type="KEGG" id="cge:100752315"/>
    <dbReference type="CTD" id="401265"/>
    <dbReference type="GeneTree" id="ENSGT00940000158352"/>
    <dbReference type="OrthoDB" id="6678352at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18260">
        <property type="entry name" value="BTB_POZ_KLHL31_KBTBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000064">
        <property type="entry name" value="Kelch-like family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000098">
        <property type="entry name" value="Kelch-like family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030604">
        <property type="entry name" value="BTB_POZ_KLHL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="73"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069961"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035299367.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="70244" checksum="AACBDBA653246E13" modified="2019-02-13" version="1">MAPKKKAMKKNKAEINEMTIIVEDSPLNKLNALNGLLEGGNSLSCVSSELTDTSYGPNLLEGLSRMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSTKRVDLNDIAPLGLATVIAYAYTGRLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVVNIAETYCLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLIDDDLQLPSELVAFQIAMKWLEFDPKRVKHAADLLSNIRFGTISAQDLVNYVQTVPRMMQDADCHKLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLITVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLGSMNQKRTHFSLSVFNGLLYAVGGRNAEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVADGRVIVTGGYIGSAYSRSVCAYDPAHDAWQELPELSTPRGWHCAVALGDRVYVMGGSQLGPRGERVDVLTVESFSPAARQWSFVAPLPVGVSTAGVSALHGRAYLLGGWNEGEKKYKKCIQCFNPELNEWTEDDELPEATVGVSCCTLAMPNSVSRESRASSVSSVPVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I7P0</accession>
    <name>A0A3L7I7P0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 16">Olfactory receptor 2A12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">LOC100771389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027254767.1">
        <property type="nucleotide sequence ID" value="XM_027398966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I7P0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001336.1">
        <property type="protein sequence ID" value="ENSCGRP00001001295.1"/>
        <property type="gene ID" value="ENSCGRG00001001015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771389"/>
    <dbReference type="KEGG" id="cge:100771389"/>
    <dbReference type="GeneTree" id="ENSGT01140000282496"/>
    <dbReference type="OrthoDB" id="6147321at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15946">
        <property type="entry name" value="7tmA_OR1330-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047940">
        <property type="entry name" value="OR1330-like_7tmA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027254767.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35597" checksum="768B078BC9DCEA60" modified="2019-02-13" version="1">MWMIPGQNQSWVSEFILLGLSSDPTTNSILFTVFLLIYLSSVMGNGLIIMLVCMDTQLHTPMYFFLCILAMLDVCYVTTTMPQMLVHLLSHSQTISFAGCWLQMYVFSALGISECTFFVVMAYDRYVAICYPLRYTVILNWGLCRRLASGSCVCGFLSALLHTFFTMSLPYCGPNKVNHYFCDSPSVRSLACMDTHFIEMVDLVLSVFLIVFPICLIMASYVCIAMAILKIKSKQGRCKAFSTCASHLTVVTFFYVPASYMYMKPNSSYSPETDKQITLFYNVFTALFNPVVYSLRNKDIKRAFLKVMGHGRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IDI6</accession>
    <name>A0A3L7IDI6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA wybutosine-synthesizing protein 3 homolog</fullName>
            <ecNumber evidence="3">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Tyw3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027250988.1">
        <property type="nucleotide sequence ID" value="XM_027395187.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312752.1">
        <property type="nucleotide sequence ID" value="XM_035456861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IDI6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029366.1">
        <property type="protein sequence ID" value="ENSCGRP00001025120.1"/>
        <property type="gene ID" value="ENSCGRG00001022820.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769973"/>
    <dbReference type="KEGG" id="cge:100769973"/>
    <dbReference type="CTD" id="127253"/>
    <dbReference type="GeneTree" id="ENSGT00940000153304"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1960.10:FF:000001">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="13">
        <location>
            <begin position="16"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027250988.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28502" checksum="0313AD5029A8C89D" modified="2019-02-13" version="1">MDRRAEFGRWKAQSLGKADLSRKGSVDEDAVRVVQLLNAQEEFFTTSSCAGRILLLDASTSDSGIQKQHCCWLLVTHKPCVKDDVMAALKGATSNAVLKFEPFILHVQCQTLQDAQTLHSAAVASGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHQGKLMVTEEYIEFLLTIANQKMEENKKRIERFYNCLQQAMERKAISSSHSETKEKNSLLCTHKNKRNQGKAHDPSITEDHEKELEGADGLGISAALFSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IJC6</accession>
    <name>A0A3L7IJC6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 16">GS homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">LOC113832761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027246707.1">
        <property type="nucleotide sequence ID" value="XM_027390906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IJC6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002860.1">
        <property type="protein sequence ID" value="ENSCGRP00001002225.1"/>
        <property type="gene ID" value="ENSCGRG00001002346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113832761"/>
    <dbReference type="KEGG" id="cge:113832761"/>
    <dbReference type="GeneTree" id="ENSGT00940000156043"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021798">
        <property type="term" value="P:forebrain dorsal/ventral pattern formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048853">
        <property type="term" value="P:forebrain morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:GABAergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:hindbrain morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021889">
        <property type="term" value="P:olfactory bulb interneuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048714">
        <property type="term" value="P:positive regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002087">
        <property type="term" value="P:regulation of respiratory gaseous exchange by nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021527">
        <property type="term" value="P:spinal cord association neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060163">
        <property type="term" value="P:subpallium neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021978">
        <property type="term" value="P:telencephalon regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000147">
        <property type="entry name" value="GS homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042191">
        <property type="entry name" value="GSH1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47421">
        <property type="entry name" value="GS HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47421:SF1">
        <property type="entry name" value="GS HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="201"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="203"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027246707.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="32095" checksum="D1B517A48FC82107" modified="2019-02-13" version="1">MSRSFYVDSLIIKDSSRPAPSLPESHPGPDFFIPLGMPSPLVMSVSGPGCPSRKSGAFCVCPLCVTSHLHSSRPPAGAGGGATGTAGAAVAGGGAAGGTGALPLLKSQFSSGPGDPQFCPRVSHAHHHHHPPQHHHHHHQPQQPGSAAAAAAAAAAAAAAAAALGHPQHHAPVCAATTYNVSDPRRFHCLTMGGSDTSQVPNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGSSRNNHASCKCVGSQAHYARSEDEDSLSPASANEDKDISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LCE9</accession>
    <name>A0A8C2LCE9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iroquois homeobox 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Iroquois-class homeodomain protein IRX-1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Irx1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255927.1">
        <property type="nucleotide sequence ID" value="XM_027400126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LCE9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001264.1">
        <property type="protein sequence ID" value="ENSCGRP00001001239.1"/>
        <property type="gene ID" value="ENSCGRG00001000951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750610"/>
    <dbReference type="KEGG" id="cge:100750610"/>
    <dbReference type="CTD" id="79192"/>
    <dbReference type="GeneTree" id="ENSGT00940000160429"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072272">
        <property type="term" value="P:proximal/distal pattern formation involved in metanephric nephron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072086">
        <property type="term" value="P:specification of loop of Henle identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003893">
        <property type="entry name" value="Iroquois_homeo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF13">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 12" id="KW-0238">DNA-binding</keyword>
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        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="188"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="480"/>
        </location>
    </feature>
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            <begin position="210"/>
            <end position="232"/>
        </location>
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            <end position="263"/>
        </location>
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        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
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            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027255927.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="50139" checksum="2F69BC954F272EC4" modified="2022-01-19" version="1">MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGTAELGAGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTTPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGVLFGSDTEGDPEKAEDDEEIDLESIDIDQIDERDGDQSNEDEEDKAEVPRARAAPPALARDQSSPLSAAEALKSQDSPLGLAKEVSEPGSTRLLSPGAAAVGLQGAQNSKPKIWSLAETATSPDGVPKASPPPPSSHPSAHGPPSGAPLQHPAFLPSHGLYTCHIGKFSNWTNGAFLAQGSLLNMRSFLSVGAPPAAPHGPHLPAPPPPQPPVQVATGVLHGDKASARSSPALPERDLVPRSDSPPQQLKSPFQPVRDNSLAPQEGTPRILAALPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LDA3</accession>
    <name>A0A8C2LDA3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100766019</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LDA3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001395.1">
        <property type="protein sequence ID" value="ENSCGRP00001001336.1"/>
        <property type="gene ID" value="ENSCGRG00001001062.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100766019"/>
    <dbReference type="GeneTree" id="ENSGT01030000234553"/>
    <dbReference type="OMA" id="NDFECKA"/>
    <dbReference type="OrthoDB" id="9606139at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="18"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027285566.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35383" checksum="F3D817A085582E83" modified="2022-01-19" version="1">MFSLKNVLYFQAGLGVLANIFLLFFCTFIILVHRSKPMDLISCQLPFIHIVLVLTGGDIGLTDIFESLNFDNDFKCKASFYIHRMMRGLSICITCLLSVFQAVTVSPSTSLLAKFKYKLKKYMIYAFFYMWFLNLSFSTNRIFYVGAFTNVSETNQMRITKYCSLFPMNYIIRVLILTATTSRDVFLVGVMLTSSAYMVIILFRHQRQCKYLHSLSHLKASPEKRATLTILLLVVVFVVMYWVDFIISSTAVLLWMYHPVILTVQKFVVNAYPTITPLVQISSDNRIINILTNLQSRFHKNFRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LFI0</accession>
    <name>A0A8C2LFI0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PDS5 cohesin associated factor A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12 13">Sister chromatid cohesion protein PDS5 homolog A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12 13" type="primary">Pds5a</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13">17A/GY</strain>
            <tissue evidence="12 13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDS5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027246561.1">
        <property type="nucleotide sequence ID" value="XM_027390760.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246563.1">
        <property type="nucleotide sequence ID" value="XM_027390762.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292675.1">
        <property type="nucleotide sequence ID" value="XM_035436784.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001005633.1">
        <property type="protein sequence ID" value="ENSCGRP00001003834.1"/>
        <property type="gene ID" value="ENSCGRG00001004743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764706"/>
    <dbReference type="KEGG" id="cge:100764706"/>
    <dbReference type="CTD" id="23244"/>
    <dbReference type="GeneTree" id="ENSGT00940000155155"/>
    <dbReference type="OMA" id="EKWEIVA"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001146">
        <property type="entry name" value="PDS5 cohesin associated factor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000064">
        <property type="entry name" value="Sister chromatid cohesion protein PDS5 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF2">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1320"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027246561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027246563.1"/>
        </source>
    </evidence>
    <sequence length="1336" mass="150633" checksum="5B562C5AB2727722" modified="2022-01-19" version="1">MDFTQPKPAAALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPHLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLTLVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDSAIRSGLELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVHCIHAIFSNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINSKSAMCNADSPKDPVLPTKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPTGVLGTVNKPLSATGRKPYVRSAGAETGSNVNTNSELSPSAGSRSREQSSEASETGVSENEENPVRIISVTPVKNIDTVKNKEINSDQPTQGNISTDRGKKRIATAAGTENIQQKADEKVDESGPPAPSKPRRGRRPKSESQGNVTKNDDLNKPTSKGRKRAAGSQESPGGLEASNAKAPKQQDGAKKAAPAERQIDLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LFJ0</accession>
    <name>A0A8C2LFJ0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100756552</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301947.1">
        <property type="nucleotide sequence ID" value="XM_035446056.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313977.1">
        <property type="nucleotide sequence ID" value="XM_035458086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LFJ0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005654.1">
        <property type="protein sequence ID" value="ENSCGRP00001003846.1"/>
        <property type="gene ID" value="ENSCGRG00001004770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756552"/>
    <dbReference type="KEGG" id="cge:100756552"/>
    <dbReference type="GeneTree" id="ENSGT00940000154333"/>
    <dbReference type="OMA" id="CICLVTY"/>
    <dbReference type="OrthoDB" id="9829410at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15418">
        <property type="entry name" value="7tmA_OR9G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035301947.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35078" checksum="748E48CB608CAD70" modified="2022-01-19" version="1">MERGNHTVTEFILLGFSTDPVMQMVLFVLFLGVYSLTLLGNTTLIILICNDSRLHTPMYFFIGNLSFLDLWYSSVYTPKILVTCISEDKSISFAGCLSQFFFSAGLAYSECYLLAAMAYDRYAAISNPLLYAQAMSRKLCLSLVMYSYTGGFVNAIILTSNTFTLDFCGDNVIDDFFCDVPPLIKLACDVRESYQSVLYFLLASNVITPTLLILASYLFIIAAILRIRSTQGRLKAFSTCSSHLISVTLYYGSILYIYSRPSSSYSLERDKMVSTFYTVLFPMLNPMIYSLRNKDVKEALRKLFKLAPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LGD6</accession>
    <name>A0A8C2LGD6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Acyl-coenzyme A amino acid N-acyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">LOC100756541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294864.1">
        <property type="nucleotide sequence ID" value="XM_035438973.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312788.1">
        <property type="nucleotide sequence ID" value="XM_035456897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LGD6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001615.1">
        <property type="protein sequence ID" value="ENSCGRP00001001489.1"/>
        <property type="gene ID" value="ENSCGRG00001001248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756541"/>
    <dbReference type="KEGG" id="cge:100756541"/>
    <dbReference type="OrthoDB" id="6347013at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2240:FF:000001">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000024">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF1">
        <property type="entry name" value="ACYL-COENZYME A AMINO ACID N-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="6">
        <location>
            <begin position="206"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035294864.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46316" checksum="61D793868C44376B" modified="2022-01-19" version="1">MIQVIATPSNALADEPVSIRATGLPPSQIVTIKATLKDEKENLFQSKAFYKANKAGEVDLERASALGGDYVGVHPMGLFWSLKPKKVFQRLLKKDVMNTPFLITLDLYDYVCLQDSATIKPKASQIVQRWFAGPGVQRKQIREGRVRGALFLPPGEGPFPGILDLFGMVGGLVEFRASLLASHGFAVLALAYFAYEDLPDKLLETDLEYFEEAADFLLAHPKIQQPGIGVISTSKGAEIGLAMACYLKQVVATVCINGSSAILDFPLRYRDLVVTAIPRARERIQVHASGAVRFRSFIDDPWNKLNLHSILPVEKAQGWILFIVGENDESLDSKACAQRAMDQLHSHGRSSGRMLAYPGAGHLIEPPYSPCCFASWTFGMPNPLLWGGDPIAHAAAQEHSWREIQKFFRQHLTQSRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LH44</accession>
    <name>A0A8C2LH44_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 13">Interferon alpha-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">LOC100769352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha/beta interferon family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027256144.1">
        <property type="nucleotide sequence ID" value="XM_027400343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LH44"/>
    <dbReference type="Ensembl" id="ENSCGRT00001004420.1">
        <property type="protein sequence ID" value="ENSCGRP00001003128.1"/>
        <property type="gene ID" value="ENSCGRG00001003697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769352"/>
    <dbReference type="KEGG" id="cge:100769352"/>
    <dbReference type="GeneTree" id="ENSGT01000000214430"/>
    <dbReference type="OrthoDB" id="9833506at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00095">
        <property type="entry name" value="IFab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000001">
        <property type="entry name" value="Interferon alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000471">
        <property type="entry name" value="Interferon_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691:SF60">
        <property type="entry name" value="INTERFERON ALPHA-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691">
        <property type="entry name" value="TYPE I INTERFERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00143">
        <property type="entry name" value="Interferon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00266">
        <property type="entry name" value="INTERFERONAB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00076">
        <property type="entry name" value="IFabd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00252">
        <property type="entry name" value="INTERFERON_A_B_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3 8" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678523" evidence="9">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027256144.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21589" checksum="0636D00B8763A530" modified="2022-01-19" version="1">MPRLCAFLMALVVMSYWSTCSLGCDLPQTHNLRNKRALTLLAQMRRLSPLSCLKDRKVFAFPLENVDAQQIQKAQAIPVLQELTQQVLILFSSKDSSAAWETTLLDTFCTGLHQQLSDLQACLMQQVGEQEPPLSQEDSLVAVRKYFHRITVYLREKNHSPCAWEVVRAEVWRALSSSANLLARLGEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LKH1</accession>
    <name>A0A8C2LKH1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 25 member 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial solute carrier protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Slc25a16</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in the transport of coenzyme A in the mitochondrial matrix. Very little is known about the physiological function of this carrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003501053.1">
        <property type="nucleotide sequence ID" value="XM_003501005.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250821.1">
        <property type="nucleotide sequence ID" value="XM_027395020.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LKH1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009335.1">
        <property type="protein sequence ID" value="ENSCGRP00001006001.1"/>
        <property type="gene ID" value="ENSCGRG00001008006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761558"/>
    <dbReference type="KEGG" id="cge:100761558"/>
    <dbReference type="CTD" id="8034"/>
    <dbReference type="GeneTree" id="ENSGT00940000157520"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000052">
        <property type="entry name" value="Solute carrier family 25 member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="125"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027250821.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35850" checksum="F42D4679F4F04A0E" modified="2022-01-19" version="1">MAAAAALAAADPAPAVPQAAGSGGPASRRDLYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVLSALRAVPQKEGYLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTFITTKLGVSGHVHRLMAGSMAGMTAVICTYPLDVVRVRLAFQVKGEHTYSGIIHAFKTIYAKEGGFLGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSYAPTLLGRPSSDNPNVLVLKTHINLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRETMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LSY7</accession>
    <name>A0A8C2LSY7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit mu-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Ap1m1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Clathrin-coated vesicle membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027250698.1">
        <property type="nucleotide sequence ID" value="XM_027394897.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LSY7"/>
    <dbReference type="SMR" id="A0A8C2LSY7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009412.1">
        <property type="protein sequence ID" value="ENSCGRP00001006045.1"/>
        <property type="gene ID" value="ENSCGRG00001008071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759505"/>
    <dbReference type="CTD" id="8907"/>
    <dbReference type="GeneTree" id="ENSGT00940000157924"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035646">
        <property type="term" value="P:endosome to melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="168"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027250698.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48555" checksum="629298E9972CAA82" modified="2022-01-19" version="1">MSASAVYVLDLKGKVLICRNYRGDVDMAEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIEAVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LZU7</accession>
    <name>A0A8C2LZU7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="8">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Naa10</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="8"/>
    <dbReference type="RefSeq" id="XP_027288247.1">
        <property type="nucleotide sequence ID" value="XM_027432446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LZU7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015020.1">
        <property type="protein sequence ID" value="ENSCGRP00001010794.1"/>
        <property type="gene ID" value="ENSCGRG00001012595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774782"/>
    <dbReference type="KEGG" id="cge:100774782"/>
    <dbReference type="CTD" id="8260"/>
    <dbReference type="GeneTree" id="ENSGT00550000074803"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000719">
        <property type="term" value="P:negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000014">
        <property type="entry name" value="N-alpha-acetyltransferase 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF268">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027288247.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26426" checksum="13C2A171203846FE" modified="2022-01-19" version="1">MNIRNARPEDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKSNRAALHLYSNTLNFQISEVEPKYYADGEDAYAMKRDLTQMADELRRHLELKEKGRHMVLAATENKAEGKGNMLLSSGEACREKSLAAEDSAGDSKDLSEVSETTESTDVKDSSEASDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M682</accession>
    <name>A0A8C2M682_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PTB domain-containing engulfment adapter protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cell death protein 6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">PTB domain adapter protein CED-6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein GULP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15 16 17" type="primary">Gulp1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16 17">17A/GY</strain>
            <tissue evidence="15 16 17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ced-6 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003515106.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252615.1">
        <property type="nucleotide sequence ID" value="XM_027396814.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252616.1">
        <property type="nucleotide sequence ID" value="XM_027396815.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252617.1">
        <property type="nucleotide sequence ID" value="XM_027396816.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M682"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019140.1">
        <property type="protein sequence ID" value="ENSCGRP00001014902.1"/>
        <property type="gene ID" value="ENSCGRG00001015646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759296"/>
    <dbReference type="KEGG" id="cge:100759296"/>
    <dbReference type="CTD" id="51454"/>
    <dbReference type="GeneTree" id="ENSGT00940000156186"/>
    <dbReference type="OrthoDB" id="10057585at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01273">
        <property type="entry name" value="PTB_CED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000118">
        <property type="entry name" value="GULP PTB domain containing engulfment adaptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF78">
        <property type="entry name" value="PTB DOMAIN-CONTAINING ENGULFMENT ADAPTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="11">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060944"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027252615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027252616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027252617.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34417" checksum="7ACB11E2AFE817F4" modified="2022-01-19" version="1">MNRAFSRKKDKTWMHTPEALSKHYIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKSKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGMQKRIQDLETENMELKNKVQDLENQLRITQVSSSPAGSVTAKSPSTDIFDMVPFSPISQQSPTPTRNGTQLPPVPSRSTEIKRDLFGAEPFDPFNCGAGDFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MA35</accession>
    <name>A0A8C2MA35_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Disheveled-associated activator of morphogenesis 2 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Dishevelled associated activator of morphogenesis 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Daam2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307056.1">
        <property type="nucleotide sequence ID" value="XM_035451165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MA35"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019947.1">
        <property type="protein sequence ID" value="ENSCGRP00001015704.1"/>
        <property type="gene ID" value="ENSCGRG00001016238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764704"/>
    <dbReference type="KEGG" id="cge:100764704"/>
    <dbReference type="CTD" id="23500"/>
    <dbReference type="GeneTree" id="ENSGT00940000157801"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021516">
        <property type="term" value="P:dorsal spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048715">
        <property type="term" value="P:negative regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090521">
        <property type="term" value="P:podocyte cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000050">
        <property type="term" value="P:regulation of non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000001">
        <property type="entry name" value="Dishevelled associated activator of morphogenesis 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000002">
        <property type="entry name" value="Dishevelled associated activator of morphogenesis 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000012">
        <property type="entry name" value="Dishevelled associated activator of morphogenesis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF7">
        <property type="entry name" value="DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="40"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="595"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="972"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035307056.1"/>
        </source>
    </evidence>
    <sequence length="1115" mass="128534" checksum="839676366C05D698" modified="2022-01-19" version="1">MAFSKRSHHGLGFLCCFGGSDLPEIDLRDSHSLHYLDFSGPIPNPEELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIERINSMASMQNLYEFDEKETDTRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGMDPDLAPLENFNVKNIVNMLVNENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLAKESQELRQARGQVAELVAQLNELSTGPVSSPPPPGGPLPLSSSTTTDDLPPPPPPLPFSSCPPPPAPPLPPGGPPIPPGAPPCFSSGPSLPQDLFSSNDAPLRKKCTPQPSHPLKSFNWVKLNEERVSGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQGGMQEGPQRERGNVRDRGTASRLLPALEANVHRMENTSRSIVSPTSPKKELGSTEDIYLTSRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAETKPKVEAILLASRELTLSKRLKQMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELRHLSEAAKVNLAELEKEIGTLRRGLRAVEMELEYQSCQARDPNDKFVPVMSDFITVSSFSFAELEDQLNEARDKFSKALTHFGEQESKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEDDERRARMESMLKEQREKERWQRQRKVLTGSTLEESGEFDDLVSALRSGEVFDKDLSKFKRSRKRAGTQTPEVTRERVMNRLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MAK8</accession>
    <name>A0A8C2MAK8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8 11">Shiftless antiviral inhibitor of ribosomal frameshifting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Shfl</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHFL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027267271.1">
        <property type="nucleotide sequence ID" value="XM_027411470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MAK8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017244.1">
        <property type="protein sequence ID" value="ENSCGRP00001013008.1"/>
        <property type="gene ID" value="ENSCGRG00001014258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773113"/>
    <dbReference type="KEGG" id="cge:100773113"/>
    <dbReference type="CTD" id="55337"/>
    <dbReference type="GeneTree" id="ENSGT00390000005065"/>
    <dbReference type="OrthoDB" id="9423182at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001125">
        <property type="term" value="P:negative regulation of translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035456">
        <property type="term" value="P:response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034340">
        <property type="term" value="P:response to type I interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034342">
        <property type="term" value="P:response to type III interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026795">
        <property type="entry name" value="SHFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135">
        <property type="entry name" value="REPRESSOR OF YIELD OF DENV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135:SF2">
        <property type="entry name" value="SHIFTLESS ANTIVIRAL INHIBITOR OF RIBOSOMAL FRAMESHIFTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15135">
        <property type="entry name" value="UPF0515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027267271.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32475" checksum="B556C63BD9F4D313" modified="2022-01-19" version="1">MAQDGVELEKSVRRLREKFHGKVSPKKAGALMRKFGSDHTGVGRSIVYGVKQKDGQELSNDLDAQDPPEDMKQDRDIQAVATSLLPLTKANLRMFQRAQDDLIPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYEPVPGDKMWGLAEFHCPKCRHNFRGWAQMGSPSPCYGCGFPVYPTRILPPRWDRDLDRRSTHTHSCSAADCYNRREPHVPGTSCAHPKSRKQNHLPRVLHPSNPHISSGSTVATCLSQGGLVDDLDHLILEDLKEEEEDEEDGGSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MAL1</accession>
    <name>A0A8C2MAL1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Multiple epidermal growth factor-like domains protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27 30" type="primary">Megf10</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="19">Homomer. Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11. Binds with high affinity to complement C1q. Interacts (via the cytoplasmic domain) with NOTCH1 (via NICD domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Phagocytic cup</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the MEGF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035296031.1">
        <property type="nucleotide sequence ID" value="XM_035440140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MAL1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020450.1">
        <property type="protein sequence ID" value="ENSCGRP00001016206.1"/>
        <property type="gene ID" value="ENSCGRG00001016594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757958"/>
    <dbReference type="KEGG" id="cge:100757958"/>
    <dbReference type="CTD" id="84466"/>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001891">
        <property type="term" value="C:phagocytic cup"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001849">
        <property type="term" value="F:complement component C1q complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="9" id="KW-0677">Repeat</keyword>
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            <begin position="1"/>
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    <sequence length="1155" mass="123759" checksum="5432968529BF3E3D" modified="2022-01-19" version="1">MAISSNSCLGLICSLLCYWMRTASSLNLEDPNVCSHWESYSVTIQESYPHPFDQIYYTSCTDILNWFKCTRHRISYRTAYRHGEKTMYRRKSQCCPGFYESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVRCAETCRCVNGGKCYHVSGACLCEAGFAGELCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGRCACAPGFKGIDCSTPCPLGSYGINCSSHCGCKNDAVCSPVDGSCICKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGKKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTSCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLPHSNGGNANSHYFTNPSYHTLSQCATSPHVNNRDRMTIAKSKNNQLFVNLKNVNPGKRSALVDCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSNCSLSSSENPYATIKDPPALLPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVFSNNGHLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKREDGGGGGSSSSSSSNSSSSSSSNSSSSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MAM4</accession>
    <name>A0A8C2MAM4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="30">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="36 39" type="primary">Insr</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
            <tissue evidence="39">Liver</tissue>
        </source>
    </reference>
    <reference evidence="36" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="30">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="30"/>
    <dbReference type="RefSeq" id="XP_027271565.1">
        <property type="nucleotide sequence ID" value="XM_027415764.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001020360.1">
        <property type="protein sequence ID" value="ENSCGRP00001016116.1"/>
        <property type="gene ID" value="ENSCGRG00001016526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766818"/>
    <dbReference type="KEGG" id="cge:100766818"/>
    <dbReference type="CTD" id="3643"/>
    <dbReference type="GeneTree" id="ENSGT00940000155404"/>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05061">
        <property type="entry name" value="PTKc_InsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000050">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000005">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000087">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000108">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001010">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000026">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000002">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040969">
        <property type="entry name" value="Insulin_TMD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016246">
        <property type="entry name" value="Tyr_kinase_insulin-like_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF535">
        <property type="entry name" value="INSULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17870">
        <property type="entry name" value="Insulin_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000620">
        <property type="entry name" value="Insulin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 28 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="25" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="24" id="KW-0458">Lysosome</keyword>
    <keyword evidence="19 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 28 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 30" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22 30 39" id="KW-0675">Receptor</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="10 33" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 30 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 32" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="20" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="33">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678801" description="Tyrosine-protein kinase receptor" evidence="33">
        <location>
            <begin position="28"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="626"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="35">
        <location>
            <begin position="843"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="34">
        <location>
            <begin position="1013"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1350"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="1149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="1023"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28 29">
        <location>
            <position position="1047"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <begin position="1094"/>
            <end position="1100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <begin position="1153"/>
            <end position="1154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="1167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR000620-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR000620-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="RefSeq" id="XP_027271565.1"/>
        </source>
    </evidence>
    <sequence length="1372" mass="155674" checksum="540BA55767D7AD2A" modified="2022-01-19" version="1">MGSGRRRETTAAPLLVAVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHYKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILDGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDESSSECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLDEVGNVTATMPTLPDFPNISSTVVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLEPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDGSSHCHREEAGCREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MGH1</accession>
    <name>A0A8C2MGH1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protocadherin 7</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="20">Protocadherin-7 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">LOC100769505</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027242732.1">
        <property type="nucleotide sequence ID" value="XM_027386931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MGH1"/>
    <dbReference type="SMR" id="A0A8C2MGH1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021883.1">
        <property type="protein sequence ID" value="ENSCGRP00001017639.1"/>
        <property type="gene ID" value="ENSCGRG00001017637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769505"/>
    <dbReference type="KEGG" id="cge:100769505"/>
    <dbReference type="GeneTree" id="ENSGT00940000157221"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000028">
        <property type="entry name" value="Protocadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000034">
        <property type="entry name" value="Protocadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000043">
        <property type="entry name" value="Protocadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000005">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000016">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000073">
        <property type="entry name" value="protocadherin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000270">
        <property type="entry name" value="protocadherin-7 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013585">
        <property type="entry name" value="Protocadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF253">
        <property type="entry name" value="PROTOCADHERIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08374">
        <property type="entry name" value="Protocadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678903" evidence="15">
        <location>
            <begin position="31"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="144"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="312"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="435"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="539"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="643"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="756"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="917"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1071"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1222"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1001"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1071"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1127"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027242732.1"/>
        </source>
    </evidence>
    <sequence length="1258" mass="136847" checksum="93FD4CE1A62888E2" modified="2022-01-19" version="1">MLRMRTTGWARGWCLGCCLLLPLCLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGGGGGEGRRSGPADSAPYPGGGGNSASGSGGSGGSKRRLESPEGGGGTGPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLVVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGTFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIVRSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVMMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQPQDPHQGSLQSCYDSGLEESETPSSKSSSGPRLGALPLPEDNYERTTPDGSVGEAEHMENDSRPLPDVALTGKCTRECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGDRNRNLLNKKLTSSYETFSAASFSKTEEANPEDIPLTKTGEYKPSPVNTLTRREVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MLN3</accession>
    <name>A0A8C2MLN3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17 18 19" type="primary">Znf32</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016832072.1">
        <property type="nucleotide sequence ID" value="XM_016976583.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016832073.1">
        <property type="nucleotide sequence ID" value="XM_016976584.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285028.1">
        <property type="nucleotide sequence ID" value="XM_027429227.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285029.1">
        <property type="nucleotide sequence ID" value="XM_027429228.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285030.1">
        <property type="nucleotide sequence ID" value="XM_027429229.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293693.1">
        <property type="nucleotide sequence ID" value="XM_027437892.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MLN3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024621.1">
        <property type="protein sequence ID" value="ENSCGRP00001020377.1"/>
        <property type="gene ID" value="ENSCGRG00001019548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771982"/>
    <dbReference type="KEGG" id="cge:100771982"/>
    <dbReference type="CTD" id="7580"/>
    <dbReference type="OMA" id="WDFQNAF"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000475">
        <property type="entry name" value="zinc finger protein 32 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000505">
        <property type="entry name" value="zinc finger protein 32 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001002">
        <property type="entry name" value="zinc finger protein 32 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027285028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027285029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027285030.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32519" checksum="137CE76E0385D627" modified="2022-01-19" version="1">MFGFPTATLLDCHGRYAQNVAFFTYWCILHDFPLVLSDVMTEAHKYDHSEATGSSSWDFQSSFRREKVEQKSPDSKTLQEDSPGVRQKVYDCQECGKSFRQKGSLTLHERIHTGQKPFECTQCGKSFRAKGNLVTHQRIHTGEKPYQCKECGKSFSQRGSLAVHERLHTGQKPYECAICQRSFRNQSNLAVHRRVHSGEKPYRCDQCGKAFSQKGSLIVHIRVHTGLKPYACSHCRKSFHTRGNCILHGKIHTGETPYLCGQCGKSFTQRGSLAVHQRSCSQRLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MXP3</accession>
    <name>A0A8C2MXP3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">HEPACAM family member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Mitotic kinetics regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Hepacam2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027241885.1">
        <property type="nucleotide sequence ID" value="XM_027386084.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245534.1">
        <property type="nucleotide sequence ID" value="XM_027389733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MXP3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029769.1">
        <property type="protein sequence ID" value="ENSCGRP00001025523.1"/>
        <property type="gene ID" value="ENSCGRG00001023099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765391"/>
    <dbReference type="KEGG" id="cge:100765391"/>
    <dbReference type="CTD" id="253012"/>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="OMA" id="TIDYMCC"/>
    <dbReference type="OrthoDB" id="9872799at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000483">
        <property type="entry name" value="HEPACAM family member 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000624">
        <property type="entry name" value="HEPACAM family member 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000506">
        <property type="entry name" value="HEPACAM family member 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052280">
        <property type="entry name" value="HEPACAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44888:SF1">
        <property type="entry name" value="HEPACAM FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44888">
        <property type="entry name" value="HEPACAM FAMILY MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="150"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="236"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00059869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00073791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00078454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027245534.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51312" checksum="2EC84007973A3574" modified="2022-01-19" version="1">MGQDAFMESLSSMAGIFLCKIYFLLIAGVCSGLKVTVPSHTVHGIRGQALYLPVHYGFHTPASDIQIIWLFERSHTMPKYLLGSVNESVVPDLEYQHKFTMMPPNASLLINPLQFSDEGNYIVKVNIQGNGTLSSSQKIQVTVDDPVMKPVVQFYPASGAVEYVGNITLTCQVAGGTRLVYQWRKNGKPVCINSSHSLSPENNTLWIAPVTKEDVGNYSCLVSNPVSEMESDIIMPTIYYGPYGLQVNSDKGLKVGEVFTVDLGEAILFDCSADSYPPNTYSWIQRSDNTTHVIQHGPRLEVASEKVAQKTTDYMCCAYNNITGKRDETHFTIIITSVGLEKLAQKGKSLSPLASITGISLFLIISMCLLFLWKKYQPYKAIRQKLRSRSESEYRKAQTFSGHEDALGDFGIYEFVTFPDASGVPRMPTRSAPASDGVTGHDFLGTIYEVIQHIPAQQQVNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N0P9</accession>
    <name>A0A8C2N0P9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcitonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">LOC100772276</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcitonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297211.1">
        <property type="nucleotide sequence ID" value="XM_035441320.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314245.1">
        <property type="nucleotide sequence ID" value="XM_035458354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N0P9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027411.1">
        <property type="protein sequence ID" value="ENSCGRP00001023166.1"/>
        <property type="gene ID" value="ENSCGRG00001021467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772276"/>
    <dbReference type="KEGG" id="cge:100772276"/>
    <dbReference type="GeneTree" id="ENSGT00940000162876"/>
    <dbReference type="OrthoDB" id="9929923at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031716">
        <property type="term" value="F:calcitonin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150060">
        <property type="term" value="P:amylin receptor 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001984">
        <property type="term" value="P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990090">
        <property type="term" value="P:cellular response to nerve growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050965">
        <property type="term" value="P:detection of temperature stimulus involved in sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007631">
        <property type="term" value="P:feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002548">
        <property type="term" value="P:monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045779">
        <property type="term" value="P:negative regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030279">
        <property type="term" value="P:negative regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045986">
        <property type="term" value="P:negative regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048265">
        <property type="term" value="P:response to pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006939">
        <property type="term" value="P:smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021118">
        <property type="entry name" value="Calcitonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021117">
        <property type="entry name" value="Calcitonin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021116">
        <property type="entry name" value="Calcitonin/adrenomedullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018360">
        <property type="entry name" value="Calcitonin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001693">
        <property type="entry name" value="Calcitonin_peptide-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10505:SF16">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10505">
        <property type="entry name" value="CALCITONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00214">
        <property type="entry name" value="Calc_CGRP_IAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00270">
        <property type="entry name" value="CALCITONINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00113">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00258">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0372">Hormone</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679151" description="Calcitonin" evidence="13">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Calcitonin peptide-like" evidence="14">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="85"/>
            <end position="91"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR621116-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035297211.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15089" checksum="FD04B82C373265A2" modified="2022-01-19" version="1">MGFLKLSPFLVVSILFLYQAGSLHAVPFRSTLESSPGMATLSEEEARLLAALVQDYMQMKTRELEQEEEQEAEGSSLDSPRSKRCGNLSTCMLGTYTQELNKFHTFPQTAIGVGAPGKKRDVAKNLETNHHNHFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N1G7</accession>
    <name>A0A8C2N1G7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Caudal type homeobox 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Homeobox protein CDX-2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Cdx2</name>
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    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269584.1">
        <property type="nucleotide sequence ID" value="XM_027413783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N1G7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031423.1">
        <property type="protein sequence ID" value="ENSCGRP00001027176.1"/>
        <property type="gene ID" value="ENSCGRG00001024259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762482"/>
    <dbReference type="KEGG" id="cge:100762482"/>
    <dbReference type="CTD" id="1045"/>
    <dbReference type="GeneTree" id="ENSGT00940000161261"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:intestinal epithelial cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060711">
        <property type="term" value="P:labyrinthine layer development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:trophectodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Caudal type homeobox 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006820">
        <property type="entry name" value="Caudal_activation_dom"/>
    </dbReference>
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        <property type="entry name" value="Caudal_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332:SF27">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04731">
        <property type="entry name" value="Caudal_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010341"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027269584.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="33564" checksum="F90EE58B469724D5" modified="2022-01-19" version="1">MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWSTAYGAPLREDWNGYPPGGAAAANAVAHGLNGGSPAAAMGYSSPADYHAHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATGAAEQLSPSGQRRNLCEWMRKPAQPSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQQQQQPAPPPPQPSQPQPGALRSVPEPLSPVSSLQGSVPGSVPGVLGPPGGVLNPTVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QE39</accession>
    <name>A0A8C2QE39_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Testis expressed 47</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Testis-expressed protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">Tex47</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <reference evidence="1" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003502770.1">
        <property type="nucleotide sequence ID" value="XM_003502722.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247372.1">
        <property type="nucleotide sequence ID" value="XM_027391571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QE39"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008510.1">
        <property type="protein sequence ID" value="ENSCGRP00001005522.1"/>
        <property type="gene ID" value="ENSCGRG00001007269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766109"/>
    <dbReference type="KEGG" id="cge:100766109"/>
    <dbReference type="CTD" id="219557"/>
    <dbReference type="GeneTree" id="ENSGT00390000005565"/>
    <dbReference type="OMA" id="RLFMQWY"/>
    <dbReference type="OrthoDB" id="548795at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055308">
        <property type="entry name" value="TEX47-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24787">
        <property type="entry name" value="TEX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027247372.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29701" checksum="4E446C5A64C90DE7" modified="2022-01-19" version="1">MSFMVHTRKGSKKHYHVDPLLMPKVPRINYMHLQEEKHRLQLKKFLLHRMFLVGHIQENVEKKEISEYYEQLFQSILKHHLGEAVTGILLIYSSTFLHIMETSNGTFFRILLDYVAHEKEENEFMIYNMKIIVASHNIPTRLFMQWHISVIKVPVLYLEDVTQSQSLAEVTTDFLTMTHKLSLHLFKTIKVGMKGPGDNLHQIAPDLLLPEQTIQYLCKADEFLDPVTFLSMYNKPIHVTLDSEIVWPAPSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QEY0</accession>
    <name>A0A8C2QEY0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Ras-related protein Rab-23</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29 32 33 34 35 36" type="primary">Rab23</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32 33 34" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32 33 34">17A/GY</strain>
            <tissue evidence="32 33 34">Liver</tissue>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="26">Interacts with SUFU.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Phagosome membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="RefSeq" id="XP_027248638.1">
        <property type="nucleotide sequence ID" value="XM_027392837.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248639.1">
        <property type="nucleotide sequence ID" value="XM_027392838.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248640.1">
        <property type="nucleotide sequence ID" value="XM_027392839.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248641.1">
        <property type="nucleotide sequence ID" value="XM_027392840.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248642.1">
        <property type="nucleotide sequence ID" value="XM_027392841.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QEY0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010450.1">
        <property type="protein sequence ID" value="ENSCGRP00001006633.1"/>
        <property type="gene ID" value="ENSCGRG00001008994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774694"/>
    <dbReference type="KEGG" id="cge:100774694"/>
    <dbReference type="CTD" id="51715"/>
    <dbReference type="GeneTree" id="ENSGT00940000155064"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04106">
        <property type="entry name" value="Rab23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000669">
        <property type="entry name" value="Ras-related protein Rab-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034114">
        <property type="entry name" value="Rab23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="24" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0488">Methylation</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="28">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00062634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00067823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027248638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_027248639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="RefSeq" id="XP_027248640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="RefSeq" id="XP_027248641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_027248642.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26861" checksum="FAA5AF5E63583D06" modified="2022-01-19" version="1">MMEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISSWREKVVAEVGDIPTVLVQNKIDLLDDTCIKNEEAEALAKRLKLRFYRTSVKEDLNVNEVFKYLAEKHLQKLKQQITEEPEQTHTSSNKIGVFNTSVGSHLGQNSSTLNGGDVIHLRPNKQRTKKTRNPFSSCSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QKP7</accession>
    <name>A0A8C2QKP7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="21">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Nlk</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="21">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="21"/>
    <dbReference type="RefSeq" id="XP_016831735.1">
        <property type="nucleotide sequence ID" value="XM_016976246.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282362.1">
        <property type="nucleotide sequence ID" value="XM_027426561.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QKP7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023059.1">
        <property type="protein sequence ID" value="ENSCGRP00001018815.1"/>
        <property type="gene ID" value="ENSCGRG00001018447.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768473"/>
    <dbReference type="KEGG" id="cge:100768473"/>
    <dbReference type="CTD" id="51701"/>
    <dbReference type="GeneTree" id="ENSGT00940000158363"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904894">
        <property type="term" value="P:positive regulation of receptor signaling pathway via STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07853">
        <property type="entry name" value="STKc_NLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000162">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000164">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 21 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="138"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027282362.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="58292" checksum="441CC05CA5E6A36A" modified="2022-01-19" version="1">MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHHHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QPR3</accession>
    <name>A0A8C2QPR3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Programmed cell death 1 ligand 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">B7 homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Cd274</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the immunoglobulin superfamily. BTN/MOG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297785.1">
        <property type="nucleotide sequence ID" value="XM_035441894.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317469.1">
        <property type="nucleotide sequence ID" value="XM_035461578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QPR3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031476.1">
        <property type="protein sequence ID" value="ENSCGRP00001027229.1"/>
        <property type="gene ID" value="ENSCGRG00001024294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759180"/>
    <dbReference type="KEGG" id="cge:100759180"/>
    <dbReference type="CTD" id="29126"/>
    <dbReference type="GeneTree" id="ENSGT00940000161430"/>
    <dbReference type="OMA" id="YCCMISY"/>
    <dbReference type="OrthoDB" id="8680608at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046007">
        <property type="term" value="P:negative regulation of activated T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000562">
        <property type="term" value="P:negative regulation of CD4-positive, alpha-beta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001186">
        <property type="term" value="P:negative regulation of CD8-positive, alpha-beta T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032693">
        <property type="term" value="P:negative regulation of interleukin-10 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002841">
        <property type="term" value="P:negative regulation of T cell mediated immune response to tumor cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903556">
        <property type="term" value="P:negative regulation of tumor necrosis factor superfamily cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032689">
        <property type="term" value="P:negative regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905404">
        <property type="term" value="P:positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032733">
        <property type="term" value="P:positive regulation of interleukin-10 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035666">
        <property type="term" value="P:TRIF-dependent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001299">
        <property type="entry name" value="Programmed cell death 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001063">
        <property type="entry name" value="Programmed cell death ligand 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF3">
        <property type="entry name" value="PROGRAMMED CELL DEATH 1 LIGAND 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0391">Immunity</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679328" description="Programmed cell death 1 ligand 1" evidence="23">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_035297785.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33108" checksum="B6D43806D26300DE" modified="2022-01-19" version="1">MRVCAIVAIFTVCCHLVNAFTITVPKDLYEVEYGSNVTLECRFPVTHRLELLSLVVYWEKYDNPVIQFVDGKTDLKQQHLMGRFWLPKEQILMGNAGLQITNVKLLDAGIYCCMISYGGADYKRITLKVNAPYRKINHRISMDPVTSEYELTCQAEGYPEAEVIWTNSDKQTLIGNTTVTTSQTEETLFNVTSTLRINATTNDVFYCTFWRLQSGENHTAELIIPEPPAEFLPNKRTHWVLLGLLLLFLVASIVIIFCIRKQVRTLDVEKCDTEDTNSKLQNDMQFEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EYP8</accession>
    <name>A0A9J7EYP8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium/glucose cotransporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">High affinity sodium-glucose cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 5 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Slc5a1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-galactose(out) + 2 Na(+)(out) = D-galactose(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70499"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:70500"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70495"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70496"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027243027.1">
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    <dbReference type="AlphaFoldDB" id="A0A9J7EYP8"/>
    <dbReference type="GeneID" id="100767281"/>
    <dbReference type="KEGG" id="cge:100767281"/>
    <dbReference type="CTD" id="6523"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:apical plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
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        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
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        </location>
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    </feature>
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        <location>
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            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
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                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
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    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027247654.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34531" checksum="97B9E14464FA29EA" modified="2023-06-28" version="1">MAEENQTATAEFLLLGFSDLRTLQGPLFWLVLLVYLITLLGNSLIIFLTQASPALHSPMYFFLRHLSLVELLYTTDIVPRTLADLTSSHPQTISFWSCAAQMYFFIVLGISECCLLTAMAYDRYAAICQPLHYPSTLMNQQACAAMVGTSWFMGIITATTHSSLIFTLPFPRRPIIPHFLCDILPVLRLASSGKRRSEISVMTATVVFIMIPFSLIVTSYARILGAILAMASTQSRRKVFSTCSSHLLVVSLFFGTASITYIRPRAGSSVTTDRILSLFYTVVTPMLNPIIYTLRNKEVTGALKHMMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FJ56</accession>
    <name>A0A9J7FJ56_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General transcription factor 3C polypeptide 1 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Gtf3c1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027260496.1">
        <property type="nucleotide sequence ID" value="XM_027404695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763706"/>
    <dbReference type="KEGG" id="cge:100763706"/>
    <dbReference type="CTD" id="2975"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="174"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="610"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="821"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1187"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1599"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1822"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
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        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1187"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1607"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1822"/>
            <end position="1832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027260496.1"/>
        </source>
    </evidence>
    <sequence length="2106" mass="238024" checksum="E546D31C6D3673B0" modified="2023-06-28" version="1">MDALESLLDEVALEGLDGLCLPALWSRLESRSPPFPLPLEPYTQEFLWRALATHPGISFYEEPRERPDLQLQDRYEEIDLETGILESRRDPVTLEDVYPIHMILENKDGIQGSCRYFKERKDITNNIRTKSLEPRCTMVEAFSRWGKKLIIVASQDMRYRALIGLEGDPDLKLPDFSYCILERLGRSRWQGELQRDLHTTAFKVDAGKLHYHRKILNKNGLITMQSHVIRLPTGAQQHSILLLLNRFHVDRRSKYDILMEKLSMMLSTRSNQIETLGKLREELGLCERTFKRLYQYMLNAGLAKVVSLPLQEIHPECGPCKTKKGTDVMVRCLKLLKEFKRKMEDDHDDDDDEEVISKGVPPVDIVFERDMLTQTYELIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVKGFMEDEGRQRTTKYISCVFAEESDLSRQYAREKARGELLTTVSLASVQDESLMPEGEEAFLSDSESEEESGCSGKRKGRGSRGHSRASGGAGSQPHHSTPAKGGWKVLNLHPLKKPKAASLRTAELRARRSSGARDGLDTSGSSELSASFDPHNMESHSGDIAVIEEVRLDNPKESGGSQKAGRHGPGQDKPHKTYRLLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIIRLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSSTANRVKVPQTPAPQEEAEEESQEPEVPSGSGDSDPNTSLKSESGRVKKTEEKMGITPLKNYKPVIVPGLGRSIGFLPKMPRLRVMHLFLWYLVYGHPAGHTGEQPTYHSERKTGKQESSRPGAQPSSGNDWDTSEARDNTESSSWEAEMELSTEIVYVDEISWMRYVPPIPIHRDFGFGWALVSDILLCLPLSIFVQVVQVSYKVDNLEDFLNDPLKKHTLIRFLPRHIRQQLLYKRRYVFSVVENLQRLCYMGLLQFGPTEKFQDKDQVFVFLKKNAVIVDTTICDPHYNLAHSSRPFERRLYVLDSMQDVESYWFDLQCICLNTPLGVVRCPCAQKICADQGSDPEGNLRKEQESAMDKHNLERKCAMLEYTTGSREVVDEGLVPGDGLGAAGLDSSFYAHLKRNWVWTSYIINKARKNNTPENGLTGRLQTFLSKRPMPLGSGGSGRLPLWSEGKADAELCADKEEQFELDREPTSGRNRKVRGGKNQKRKRLKKEPIRKIKRRRRGEQPGAKSKKLRYQDEADQNALRMMTRLRVSWSMQEDGLLMLCRIASNVLNTKVKGPFVTWQVVRDILHATFEESLDKTSHSVGRRARYIVKNPQAFMNYKVCLAEVYQDKALVGDFMSRKGNYEDPKVCAKEFKEFVEKLKEKFSSGLRNPNLEIPNTLQELFAKYRVLAIGDEKDRVRKEDELNSVEDIHFLVLQNLIQSTLSLSNSQSNSCQSFQIFRLYREFREPVLVRAFMECQKRSLVNRRRVSHSQGPKKNRAVPFVPMSYQLSQSYYKLFTWRFPTTICTESFQFYDRLRSAGILDQPDHFSFKDLDSSDPPSDLVAFSLDSPGGHCVTTLALFSLGLLSVDVRIPEQIVVVDSSMVESEVMKSLGKDGGLDDDDEEEDLDEGSGAKRQGVEVKAHQASHTKYLLMRGYYTMPGVVSTRNLNPNDSIVVNSCQVKFRLRSTPAPTQLGPTGFTATPLEELQAGPSCLPASFTSLVDPQLRTCCPEEFAHQMAQSGYSPEDMVASLEILQAVAAADCFGVDREKLSRQFSALEKTVGERTRTFSDYVQDLLEQQQVMEVGGNTVRLVAMASAHPWLLHSMRLKDTEVDTKASGDDSQARLPEGSIGEDHTFEATAVPPDSSHSTRKRAHCSIQSNETDAEEAIRLPAKRPTLQDVRVLANPRLGAEEQTEAQALTLLAAPEDAGAGIPRQENQESVGVSGLEQLGCEFQLPEGSEDPRGLTDSNMAQAAWESSCERVCFIGRPWRGVDGRLNMPVCKGMMEAVLYHIMSRPGVPESCLLQYYQGVLQPVAVLELLRGLESLGCIQKRLLKKPAVVSLFSKPVVEGLGQTSEIEAVSCHESTVTFYEPTLDCTIRLGRVFPHDVNWNKWIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FJM3</accession>
    <name>A0A9J7FJM3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100769732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003514462.1">
        <property type="nucleotide sequence ID" value="XM_003514414.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261567.1">
        <property type="nucleotide sequence ID" value="XM_027405766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FJM3"/>
    <dbReference type="GeneID" id="100769732"/>
    <dbReference type="KEGG" id="cge:100769732"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000011">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039962949" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="35"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027261567.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="62830" checksum="2F8D68040965A447" modified="2023-06-28" version="1">MSLDRFPGWLNVVACGLLLLLLHVQGRDSSKINVIRNTHTGKVRGSLVHVKDTKVGAHNFLGIPFAKPPVGPLRFAPPEPPESWSGVRDGTSQPAMCLQNDDIMNLEGLKRIKMIMPPISMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALIIGMASWYDGSMLAAIEDVVVVNIQYRLGVLGFFSTGDQHARGNWGFLDQVAALRWVQQNIAHFGGNPDQVTIFGESAGGISVSLHVVSPMSQGLFHGAIMQSGVALLPHLISNTSEMVFMMVANLSRCATWNSQSLVHCLRGKSEAEILAINKAFRIIPAVVDGEFLPRHPQELLASADFHSVPSIIGVNNDEYGWILPLIFSSSQTLKKITRRTLKAILKSTTVELLMLPPECSDLLMEEYMGDTKDPQTLQIQFTEMMGDFMFVVPALQVAHFQRSHAPVYFYEFQHRPNFLKDLKPHHVKADHGDEVFLIFGSFFWGVKINLTVKEKLLSRRMMKYWANFARHGNPNSEGLPYWPVSDQNEEYLQLDIQSSVGHALKARRQQFWTKTLPQKIQELKGAHGKNKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FT17</accession>
    <name>A0A9J7FT17_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100755444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027266134.1">
        <property type="nucleotide sequence ID" value="XM_027410333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FT17"/>
    <dbReference type="GeneID" id="100755444"/>
    <dbReference type="KEGG" id="cge:100755444"/>
    <dbReference type="OrthoDB" id="9440694at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15416">
        <property type="entry name" value="7tmA_OR5P-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027266134.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34585" checksum="C47336759FAF67BA" modified="2023-06-28" version="1">MALLEDGNHTAVTEFILLGLTDDPVLRVVLFTIIMCIYLVTMSGNLSTILLIRVSSQLHHPMYFFLSHLASADIGYSSSVTPNMLVNFLVERSTISYFGCGIQLGSAVFFGTVECFLLAAMAYDRFVAICSPLLYSTKMSTEVCVQLLVGSYIGGFLNASSFTLSFFSLLFCGPNRVNHFFCDFAPLVKLSCSDASVPAVVPSFTAGSIIVVTVLVIAVSYIYILITILKMHSTEGRHKAFSTCTSHLTAVTLFYGTITFIYVMPKSSYSTDQNKVVSVFYMIVIPMLNPLIYSLRNNEIKGALKRQISRKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FYW4</accession>
    <name>A0A9J7FYW4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Jag2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272461.1">
        <property type="nucleotide sequence ID" value="XM_027416660.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FYW4"/>
    <dbReference type="GeneID" id="100753300"/>
    <dbReference type="KEGG" id="cge:100753300"/>
    <dbReference type="CTD" id="3714"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000148">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000310">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000431">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000445">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000473">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000824">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3510:FF:000006">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056986">
        <property type="entry name" value="JAG1_1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026219">
        <property type="entry name" value="Jagged/Serrate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF12">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23575">
        <property type="entry name" value="JAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02059">
        <property type="entry name" value="JAGGEDFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 15" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="15 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039940760" description="Delta-like protein" evidence="18">
        <location>
            <begin position="25"/>
            <end position="1248"/>
        </location>
    </feature>
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        <location>
            <begin position="1085"/>
            <end position="1108"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="348"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="386"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="424"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="499"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="537"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="597"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="637"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="675"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="752"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="790"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="828"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1116"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1167"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1116"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1185"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
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    <feature type="disulfide bond" evidence="14">
        <location>
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        </location>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
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            <end position="421"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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            <end position="534"/>
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    <feature type="disulfide bond" evidence="13">
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            <end position="572"/>
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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            <end position="748"/>
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    <feature type="disulfide bond" evidence="13">
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            <end position="787"/>
        </location>
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    <feature type="disulfide bond" evidence="13">
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            <end position="825"/>
        </location>
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    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="854"/>
            <end position="863"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="13">
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            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027272461.1"/>
        </source>
    </evidence>
    <sequence length="1248" mass="134933" checksum="76B5FDDFD671B6ED" modified="2023-06-28" version="1">MRARGRGRLPGRLRLLLLLLCVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPPAGAAGDRARARSRTGGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPDEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSPTCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGKFCDECVPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCINAEPDQYLCACPDGYLGKNCERAEHACASNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCLPGWKGINCHININDCHGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYDKCASSPCRRGGVCEDLVDGFRCHCPRGLSGLLCEVDVDLCEPSPCLNGAHCYNLEDDYYCACPEDFGGKNCSVPRETCPGGACRVIDGCGFEAGSRTHGVAPSGICGPHGHCVSLPGGNFSCVCDSGFTGTYCHENIDDCMGQPCRNGGTCIDEVDSFRCFCPSGWEGELCDINPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDIYTCSNGGTCYDNGDTFRCACPPGWKGSTCTIAKNSSCLPNPCVNGGTCVGSGDSFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCNCPPGRSGPRCQEVVIFRRPCWSRGMSFPHGSSWIEDCNSCRCLDGRRDCSKVWCGWKPCLLSGQPNALSAQCPPGQQCQEKALGQCLQPPCENWGECAAEEPLPPSTPCLPRTTHLDNNCARLTLRFNRDQVPQGTTVGAICSGIRALPATRAVAHDRLLLLLCDRASSGASAVEVAVSFSPARDLTDSSLIQSTAHAIVAAITQRGNSSLLLAVTEVKVETVVMGGSSTGLLVPVLCSVFSVLWLVCVVICVWWTRKRRKERERSRLPRDESANNQWAPLNPIRNPIERPGSSGLGTGGHKDVLYQCKNFTPPPRRAGEALPGPAGHGAVGEDEEDEELGREDGDSPEAEKFLSHKFTKDPSCSLGRPACWAPGPKVDNRAVKSTKDVRCAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G1N7</accession>
    <name>A0A9J7G1N7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Gephyrin</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="31">Molybdopterin molybdenumtransferase</fullName>
                <shortName evidence="31">MPT Mo-transferase</shortName>
                <ecNumber evidence="31">2.10.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="31">Domain E</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="31">Molybdopterin adenylyltransferase</fullName>
                <shortName evidence="31">MPT adenylyltransferase</shortName>
                <ecNumber evidence="31">2.7.7.75</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="31">Domain G</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="35" type="primary">LOC100762786</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
            <tissue evidence="35">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="function">
        <text evidence="31">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="function">
        <text evidence="28">Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:35048"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="EC" id="2.7.7.75"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:31332"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 31">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 31">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="30">Homotrimer, homodimer and homooligomer. Interacts with SRGAP2 (via SH3 domain). Interacts with GLRB. Interacts with GABARAP. Interacts with GABRA3. GABRA3 and GLRB occupy overlapping binding sites. Interacts with ARHGAP32; IQSEC3, INSYN1 and INSYN2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Postsynaptic cell membrane</location>
            <topology evidence="29">Lipid-anchor</topology>
            <orientation evidence="29">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="31">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="31"/>
    <dbReference type="EC" id="2.7.7.75" evidence="31"/>
    <dbReference type="RefSeq" id="XP_027274135.1">
        <property type="nucleotide sequence ID" value="XM_027418334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G1N7"/>
    <dbReference type="GeneID" id="100762786"/>
    <dbReference type="KEGG" id="cge:100762786"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099091">
        <property type="term" value="C:postsynaptic specialization, intracellular component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007529">
        <property type="term" value="P:establishment of synaptic specificity at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097112">
        <property type="term" value="P:gamma-aminobutyric acid receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072579">
        <property type="term" value="P:glycine receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099645">
        <property type="term" value="P:neurotransmitter receptor localization to postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.340.10:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.10:FF:000004">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="23" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15 31" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 31" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 31" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="18 31" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="11 31" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="33">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="33">
        <location>
            <begin position="549"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="32">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00055539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00059974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00060421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00062706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="RefSeq" id="XP_027274135.1"/>
        </source>
    </evidence>
    <sequence length="783" mass="84904" checksum="FC519BC30D22D461" modified="2023-06-28" version="1">MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEKFPTFPFCGLQKGATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKKHPFYTSPVFMAHGQPIPGIISYSHHGTGSADKRIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G2H7</accession>
    <name>A0A9J7G2H7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Basigin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Bsg</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Basolateral cell membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027275257.2">
        <property type="nucleotide sequence ID" value="XM_027419456.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G2H7"/>
    <dbReference type="GeneID" id="100689246"/>
    <dbReference type="KEGG" id="cge:100689246"/>
    <dbReference type="CTD" id="682"/>
    <dbReference type="OrthoDB" id="5970915at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001329">
        <property type="entry name" value="Basigin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000387">
        <property type="entry name" value="Neuroplastin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF107">
        <property type="entry name" value="BASIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01856">
        <property type="entry name" value="BASIGIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0465">Mannose-binding</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039893535" description="Basigin" evidence="15">
        <location>
            <begin position="46"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027275257.2"/>
        </source>
    </evidence>
    <sequence length="293" mass="31761" checksum="837CB8DC9EB1837E" modified="2023-06-28" version="1">MRAPLPPSLLIERRSGAALGRGDMAAALLLALGFALLCGQGACAAAGTVVTSINDVGSKTHLTCSLNSSGVDIIGHRWMRGGKILQEDTLPDLQTQYTVDIDDRSGDYACIFLPEPVGRSNIVVEGPPRIKVGKKSEHSSEGENVRLICKSESSHPPVTEWSWFKTSDSGDQLITNSSESKYVVISTADRSELTISNLDINSDPGTYMCNATNTQGSVQEIMTLRVRSRLAALWPFLGIVAEVLVLVTIIFIYEKRRKPDQTLDEDDPGAAPLKGSGHHMNDKDKNVRQRNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G517</accession>
    <name>A0A9J7G517_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Acp4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027276636.1">
        <property type="nucleotide sequence ID" value="XM_027420835.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297783.1">
        <property type="nucleotide sequence ID" value="XM_027441982.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G517"/>
    <dbReference type="GeneID" id="100757346"/>
    <dbReference type="KEGG" id="cge:100757346"/>
    <dbReference type="CTD" id="93650"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120154">
        <property type="term" value="P:negative regulation of ERBB4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000010">
        <property type="entry name" value="Prostatic acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF145">
        <property type="entry name" value="TESTICULAR ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039901944" description="acid phosphatase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027276636.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="48895" checksum="71A977ECFF4D17C3" modified="2023-06-28" version="1">MAEPGSQGHTAGLLLLLLLLLLPPQALLEGPLLFVALVFRHGDRAPLASYPTDPHKEAASTLWPRGLGQLTKEGIRQQLELGRFLRRRYKAFLSPEYRREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPEADWKPIPVHTVPVSEDKLLRFPMRSCPRYHELLRESTEAADYQEALEGWTDFLTRLGNFTGLSLVGEPLRRAWKVLDTLICQRAHGLALPSWASPDVLRTLSQISALDIRAHVGPPRAAEKAQLTGGILLDAILSNFSRAQRLGLPLKMVMYSAHDSTLLALQGALGLYDGNTPPYAACMAFEFRGSSRDPEEEDGENVTISLIYRNDTSRPPLPLRVPGCPAPCPLGRFQQLTAPARPPAHGAPCHGSYEPTSPPGDSPLHRGGSGEFPGPGIHNPNVLPAATVPLLAGAVAVLAVLSLGLGLLAWRPSCLRALGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G775</accession>
    <name>A0A9J7G775_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 57</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Lrrc57</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003498093.1">
        <property type="nucleotide sequence ID" value="XM_003498045.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277905.1">
        <property type="nucleotide sequence ID" value="XM_027422104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G775"/>
    <dbReference type="GeneID" id="100757487"/>
    <dbReference type="KEGG" id="cge:100757487"/>
    <dbReference type="CTD" id="255252"/>
    <dbReference type="OrthoDB" id="1728874at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000458">
        <property type="entry name" value="Leucine rich repeat containing 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000230">
        <property type="entry name" value="Leucine-rich repeat-containing protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF62">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="100"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027277905.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31447" checksum="29557F3BF88CD788" modified="2023-06-28" version="1">MMSQGVPARAEALGERLRRARVPGVPWRSLLCAERELSRSARMGNSALRAHVETAQKTGVFQLKDRGLTEFPSELQKLTSNLRTIDLSNNKIDSLPPQLIGKFTLLKSLSLNNNKLTVLPDELCNLKKLETLSLNNNLLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVVDLSKNQIRSILDTVGELQAIELNLNQNQISQISVKISCCPRLKVLRLEENCLELSMLPQSILNDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GHP7</accession>
    <name>A0A9J7GHP7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="19">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Bcat1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:24802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:18322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24814"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="19"/>
    <dbReference type="RefSeq" id="XP_027285947.1">
        <property type="nucleotide sequence ID" value="XM_027430146.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GHP7"/>
    <dbReference type="GeneID" id="100763658"/>
    <dbReference type="KEGG" id="cge:100763658"/>
    <dbReference type="CTD" id="586"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF70">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 19 21" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11 19" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027285947.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42895" checksum="7A8A611543D2AAC2" modified="2023-06-28" version="1">MKDCSNGCSAPFAADRGSEVAETFRAKDLIITPATVLKEKPDPDTLVFGASFTDHMLIVEWSSASGWEKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMRRMCRSAVRTTLPVFDQEELLECIRQLIQIDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPSKALLFVVLSPVGPYFSSGTFKPVSLWANPKYVRAWEGGTGDCKMGGNYGASLLAQCEAMENGCQQVLWLYGQDNQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRQSIIELAQQWGEFKVCERYLTMDDLTTALEGNRVKEMFGSGTACVVCPVSDILYKGQMLHIPTMENGPKLASRLLGKLTDIQYGREESDWTILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJ49</accession>
    <name>A0A9J7GJ49_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Methyl-CpG-binding protein 2</fullName>
            <shortName evidence="12">MeCp-2 protein</shortName>
            <shortName evidence="12">MeCp2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Mecp2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FNBP3. Interacts with CDKL5. Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2. Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1. Interacts with TBL1X; recruits TBL1X to the heterochromatin foci.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <text evidence="12">Colocalized with methyl-CpG in the genome.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027288254.1">
        <property type="nucleotide sequence ID" value="XM_027432453.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJ49"/>
    <dbReference type="GeneID" id="100773625"/>
    <dbReference type="KEGG" id="cge:100773625"/>
    <dbReference type="CTD" id="4204"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010385">
        <property type="term" value="F:double-stranded methylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000026">
        <property type="term" value="P:regulation of multicellular organismal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043576">
        <property type="term" value="P:regulation of respiratory gaseous exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01396">
        <property type="entry name" value="MeCP2_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.890.10:FF:000004">
        <property type="entry name" value="Methyl-CpG-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017353">
        <property type="entry name" value="Me_CpG-bd_MeCP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF6">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038006">
        <property type="entry name" value="Methyl_CpG_bd_MeCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MBD" evidence="14">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="156"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="332"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027288254.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="53890" checksum="FD72CAC6376F3D06" modified="2023-06-28" version="1">MLREDAKIRKTLSQQDEREEKSEDQDLQGLKDKPLKFKKVKKDKKEDKEGKHEPLQPSAHHSAEPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAASSEGVQVKRVLEKSPGKLLVKMPFQASPGGKNEGGGATTSAQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVHETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSSSASSPPKKEHHHHHHHSESPKAPMPLLPPPTPPEPESSEDPISPPEPQDLSSSICKEEKMPRGGSLESDGCPKEPAKTQPMVAATTATVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GLU1</accession>
    <name>A0A9J7GLU1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Importin-8 isoform X7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ipo8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027285854.1">
        <property type="nucleotide sequence ID" value="XM_027430053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GLU1"/>
    <dbReference type="GeneID" id="100762731"/>
    <dbReference type="CTD" id="10526"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000053">
        <property type="entry name" value="Importin 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF26">
        <property type="entry name" value="IMPORTIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="886"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027285854.1"/>
        </source>
    </evidence>
    <sequence length="1085" mass="125155" checksum="C13413D7FF7C1827" modified="2023-06-28" version="1">MDLNRIIQALKGTIDPKLRIAAETELNQSYKIINFAPSLLRIIVSDQVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDSIVEGIIRSPDLVRVQLTMCLRVIIKHDFPGHWPAVVDKIDYYLQSPNSGSWLGSLLCLYQLVKTYEYKKAEEREPLLAAMQIFLPRIQQQILQLLPDASHYSVLLQKQILKIFYALVQYALPLQLVNHQTMTTWMEIFRTIIDRMVPPETLQIDEDDRPELVWWKCKKWALHIAARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRRKEYIAPRVLQQAFNYLNQGVVHAVTWKQLKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQALLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLFKDQIELFLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIEDEEMPVKVEAALALQSLISNQTQAKEHMRPHVRPIMQELLHIVRETENDDVTNVVQKMICEYSQEVASIAVDTTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHHEIIQQLENICLRIIDLVLQKRVIEFYEEILSLAYSLTCHAISPQMWHLLGILYEIFQQDFSEYFTDMMPLLHNYVTVDTNALLSNPKHLEVLFTMCRKVLYGEAGEDAECFAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPELLLHTLEQVQLPHNPGPVTSQFINQWMNDTDYFLGHHDRKMCIIGLSILLELQHRPPAVDAVAAQILPSILFLFLGLKQVCATRELVNRGDPSKAEKADMEENEEISSEEEEETSVTAQAMQSHNGRVEEEEEDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDAAWYQLLVAPLSEDQKRKLQEVYTVAEHRRTMAGQSPGGCHQGGFTFEDKGIFSAFTFGVAPSNNRKAHPTVHRPSSPLLHISRDARGPREREARGCVIGIRQPWTRSPFPCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQ96</accession>
    <name>A0A9J7GQ96_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleolar protein 4 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100770406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035296148.1">
        <property type="nucleotide sequence ID" value="XM_035440257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GQ96"/>
    <dbReference type="GeneID" id="100770406"/>
    <dbReference type="OrthoDB" id="10047222at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056549">
        <property type="entry name" value="HTH_NOL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF17">
        <property type="entry name" value="NUCLEOLAR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23079">
        <property type="entry name" value="HTH_NOL4_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 4 helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035296148.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="71014" checksum="779530C3F6F4E47F" modified="2023-06-28" version="1">MESERDMYRQFQDWCLRTYGDSGKTKTVTRKKYERIVQLLNGSESSSTDNAKFKFWVKSKGFQLGQPDEVHGGGGGAKQVLFVRVKTTDGVGVDEKLSLRRVAVVEDFFDIIYSMHVETGPNGEQIRKHAGQKRTYKAISESYAFLPREAVTRFLMSCSECQKRMHLNPDGTDHKDNGKPPTLVTSMIDYNMPITMAYMKHMKLQLLNSQQDEDESSIESDEFDMSDSTRMSAVNSDLSSNLEERMQSPQTLHGQPDDDSAAESFNGNETLGHSSVASGGAHGRETGDSSSDGKTGLEQEQPLNLSDSPLSGQLASEYRIDDQGSNGKSKYKNLLISDLKMEREARENGSKSPAHSYSSYDSGKNESVDRGAEDLSLNRGDEDEDDHDEHEDSEKVNETDGVEAERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAIIDSCRRQFPEYQERARKRIRTYLKSCRRMKRSGFEMVRPVWNHLHSYTQKSLLAVATESESRNAAKRCACTAAQDEAISADKQCKPEAAQATYSTSTVPGSQEVLYINGNGTYSYHSYRGLGGGLLNLNDTSSSGPTDLSMKRQLATGSGSSSSSNSRPQLSPTEINAVRQLVAGYRESAAFLLRSADELENLILQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GRS4</accession>
    <name>A0A9J7GRS4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LOW QUALITY PROTEIN: protein patched homolog 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Ptch2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295575.1">
        <property type="nucleotide sequence ID" value="XM_035439684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753887"/>
    <dbReference type="KEGG" id="cge:100753887"/>
    <dbReference type="CTD" id="8643"/>
    <dbReference type="OrthoDB" id="5873834at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009957">
        <property type="term" value="P:epidermal cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045606">
        <property type="term" value="P:positive regulation of epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000003">
        <property type="entry name" value="protein patched homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000007">
        <property type="entry name" value="Protein patched homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004766">
        <property type="entry name" value="TM_rcpt_patched"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00918">
        <property type="entry name" value="2A060602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF3">
        <property type="entry name" value="PROTEIN PATCHED HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1089"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="394"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035295575.1"/>
        </source>
    </evidence>
    <sequence length="1187" mass="129728" checksum="0D991738AC969753" modified="2023-06-28" version="1">MVRPLSLGELPPNYTPPARSAAPQILTGSLQAPLWLRAYFQGLLFSLGCRIQRHCGKVLFLGLVAFGALALGLRVAVIETDLEQLWVEVDSRVSQELHYTKEKLGEEAAYTSQMLIQTAQQEGENVLTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPQQLLEELGPFASLEGFRELLEKAQVGQAYVGRPCLDPDDQHCPPSAPNHHSRQAPSVAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQTWQRRFVQLAQEALPANASQKIHAFSSTSLDDILHEFSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGXXSAWFLSLPYSVLSSXEYVPALSWQERMGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCFSSPCSAQVIQILPQELGDRTVPVGVAHLTATVQAFTHCETSSGHVVTILPPQTHLMSPSSDPLSSELCSPGGSTRDLLGQEEGTRPKAAREPLLCAQWTLAHFARYQFAPLLLQTQVKALVLVFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYFRSWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGNSQEPLDFNQLTTRKLVDEEGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPAAQPLEFAQFPFLLHGLQKTADFVEAIEGARAACMEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAICILLVCTFLVCALLLLNPWTASLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAARALEQTFAPVTDGAVSTLLGLLMLAGSNFDFIIRYFFVVLTVLTLLGLLHGLLLLPVLLSILGPPPQVVQVYKESPQVLSPAAPRRGGLRWGMPHTLPQSFARVTTSMTVALHPPPLPGAYVHPASDEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GSP1</accession>
    <name>A0A9J7GSP1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphodiesterase</fullName>
            <ecNumber evidence="12">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Pde8b</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_035295011.1">
        <property type="nucleotide sequence ID" value="XM_035439120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GSP1"/>
    <dbReference type="GeneID" id="100755939"/>
    <dbReference type="CTD" id="8622"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000002">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000023">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08629">
        <property type="entry name" value="PDE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="296"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="15">
        <location>
            <begin position="561"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="414"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="637"/>
            <end position="641"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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        <location>
            <position position="678"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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        <location>
            <position position="678"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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        <location>
            <position position="803"/>
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        <ligand>
            <name>AMP</name>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="803"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="855"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035295011.1"/>
        </source>
    </evidence>
    <sequence length="907" mass="101213" checksum="521168372D8C3D22" modified="2023-06-28" version="1">MGCAPSIHVSQSGVIYCRDSDESNSPRQTSSLSQGPTAPLHGLFVQTDAADAMPPSRAAGPSGAVRVRRSRAELGSGSSTGSSGPAVTTCRGRRRHCCSSAEAETQTSYTSVKVNASCLGGALFIKPITAIYLHTQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTRNFDAEAVCRSIRATNPSEHTVILAVVSQASDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHRIHRDSGDNSQTEPPSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPTSIAQLLDNEESWDFNIFELEAVTHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GT19</accession>
    <name>A0A9J7GT19_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Mgmt</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="6"/>
    <dbReference type="RefSeq" id="XP_035297176.1">
        <property type="nucleotide sequence ID" value="XM_035441285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GT19"/>
    <dbReference type="GeneID" id="100767894"/>
    <dbReference type="KEGG" id="cge:100767894"/>
    <dbReference type="CTD" id="4255"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000214">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.70:FF:000001">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.70">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460:SF1">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methylguanine DNA methyltransferase ribonuclease-like" evidence="22">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="21">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035297176.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22277" checksum="7A008BACBB788218" modified="2023-06-28" version="1">MAETCKMKYTVLDSPLGKIELCGCERGLHGIRFLSGKTPSSDPKEAPASPELLGGPEDLPESLVQCTTWLEAYFQEPAATEGLPLPALHHPVFQQDSFTRQVLWKLLKVVKFGEMVSYQQLAALAGNPKAARAVGGAMRNNPVPILIPCHRVICSNGSIGNYSGGGQAVKEWLLAHEGIPTRQPACKDLGLTGTRLKPSGGSTSSKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GV37</accession>
    <name>A0A9J7GV37_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-Pol polyprotein</fullName>
            <ecNumber evidence="3">2.7.7.49</ecNumber>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC103164217</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="3"/>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035298340.1">
        <property type="nucleotide sequence ID" value="XM_035442449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GV37"/>
    <dbReference type="GeneID" id="103164217"/>
    <dbReference type="KEGG" id="cge:103164217"/>
    <dbReference type="OrthoDB" id="9893755at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09273">
        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06095">
        <property type="entry name" value="RP_RTVL_H_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03715">
        <property type="entry name" value="RT_ZFREV_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039464">
        <property type="entry name" value="Gag-pol_Znf-H3C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF38">
        <property type="entry name" value="LRRGT00076-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16721">
        <property type="entry name" value="zf-H3C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="15">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="201"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="17">
        <location>
            <begin position="636"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="902"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035298340.1"/>
        </source>
    </evidence>
    <sequence length="1195" mass="133164" checksum="B8571D3BE6AB5E2B" modified="2023-06-28" version="1">SQGQVPPPEPRVTLNVGGQPVTFLVDTGAQHSVLTQTQGPLSTRTAWVQGATGGKLHRWTTERKVHLSTGHVTHSFLLVPECPYPLLGRDLLSKVGAHIHFHQKGATITGEGGQPLQVLTLRLEDEYRLLEDPLPPSPTMESSWLEKYPQAWAETAGMGLAKKQPPLIINLKPSATPAAIKQYPLSQEAREGIRPHINRLLQQGILRPCHSPWNTPLLPIKKPGTGEYRPVQDLREVNRRTEDIHPTVPNPYNLLSMLPPSHIWYTVLDLKDAFFCLRLSPQSQPMFAFEWKDPETGFSGQLTWTRLPQGFKNSPTLFDEALHQDLADFRIHNPNLILLQYVDDLLLAAESEKDCLQGTGALLQKLGELGYRASAKKAQLCREQVTYLGYRLQGGQRWLTESRKQAVALIPAPKSSREVREFLGSAGFCRLWIPGFAELAAPLYPLTKANTPFSWTEEHQKAFDGIKKALLSAPALSLPNINKPFTLYVDEKAGMAKGVLTQQLGPWKRPVAYFSKKLDNVAMGWPPCLRMVAAVAVLTKDADRLTLGQQLTVIAPHAIEAVVRQPPDRWLSNARMTHYQALLLNPDRLRFGAATSLNPATLLPDADAETALPHDCRLILAETCGAREDLMDQPLQGAEHTWFTDGSSFLQDGIRKAGAAVVDGQTTIWASALPPGTSAQRAELIALTQALKMAEGRRVNIYTDSRYAFATAHVHGEIYRRRGLLTSAGKDIKNKTEILELLQALFLPRRLSIIHCPGHQKGNDPVARGNRMADEEARKAALGPQVLSLKTSDPTSCQGFEYTDSDLETVQNLGANYDQEANVWRYQGKILLPQGAAKELLSQLHRWTHLGHKKLKALLQREEQTYYIHNLNALIQQITSTCTPCAKVNTGRFKLPEGTRVRGERPGTNWEVDFTEIRPGSFGNRYLLVFIDTFSGWTEAFPTKHETAQVVVKKILKEIFPRFGLPKVIGSDNGPAFVSQVSQMVAKTLGINWKLHCAYRPQSSGQVERANRTIKETLTKLALETGAKDWVQLLPMALFRVRNTPSVHGLTPFEILFGGPPPIMDVFPADPNHSVNPPSLQARLRALQIIQNQIWKPLAAVYQAGNPAVPHPFQIGDSVYIRRHQSKTLEPRWKGPYTVLLTTPTALKVDGIAAWVHASHAKKANTSENWVTNETPKWKLQRTQNPLKIRLLRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GVM6</accession>
    <name>A0A9J7GVM6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Calcium-responsive transcription factor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7" type="primary">Carf</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3 4 5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4 5">17A/GY</strain>
            <tissue evidence="3 4 5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_016821323.1">
        <property type="nucleotide sequence ID" value="XM_016965834.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016821329.1">
        <property type="nucleotide sequence ID" value="XM_016965840.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016821331.1">
        <property type="nucleotide sequence ID" value="XM_016965842.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248707.1">
        <property type="nucleotide sequence ID" value="XM_027392906.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252802.1">
        <property type="nucleotide sequence ID" value="XM_027397001.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252803.1">
        <property type="nucleotide sequence ID" value="XM_027397002.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252804.1">
        <property type="nucleotide sequence ID" value="XM_027397003.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252805.1">
        <property type="nucleotide sequence ID" value="XM_027397004.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296860.1">
        <property type="nucleotide sequence ID" value="XM_035440969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GVM6"/>
    <dbReference type="GeneID" id="100768109"/>
    <dbReference type="KEGG" id="cge:100768109"/>
    <dbReference type="CTD" id="79800"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14694">
        <property type="entry name" value="CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14694:SF1">
        <property type="entry name" value="CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027252802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027252803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027252804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027252805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035296860.1"/>
        </source>
    </evidence>
    <sequence length="729" mass="80994" checksum="BED0B3CD8DE8E42B" modified="2023-06-28" version="1">MEQCRSVGVSCSDEESKGETRESERLTCMDSGDSSFGQNDSPTILPITAPETDDSLTSQDMPETLTDTQTLHAEQFHLLDPNGQPVQYDLQSLEESSAQMTGMAQVIISQEPLVDVTSPHDASEEKPTDRGSPPVRADTLEVSANYILRSQASPVIPKKPGTRMLEEPLLAPLQPLSSNTPIWACRLRSCEKIGDSYRGYCVSETELESILTFHKQQTQSVWGTRQSPSPAKPATRLMWKSQYVPYDGIPFVNAGTSHQLLRGSPAAVLYCERIHFILVGSRAVVMECQYGPRRKGFQLKRINEQESRSCHLYKATCPARIYIKKVQKFPEYRVPTDPQIDRKVIRMEQEKAFTMLKKNLVDAGGVLRWYVQLPTQQAHQYHELETRGLPLSPSPFRMSSLEEEETVVRDENCALPSRLHPQVAHKIQELVSQGVGQVYAVRKQLRKFVERELFKPDEVPERHNLSFFPTVNDIKNHIHEVQKSLRTGEEAYNSETIPATLQWTTDSGNILRETVTVTFAEGNSLGEPVTSKVGTSRTQTSLSPEPFHLVSPLSSFQPKIFSHLQGLKLQPSLSPLDGSQALVSESSHLSSSPSRLVDTAGNTVVNSHSLPHAQSHSLPADPCPTQNNSAAVIGSLPESVQNLVVMDQLVEVEDVEDAGNLEGSVNRILLGDVQTIPIRIIDSHPTLIEENLEDTLSVNQVKQEPKEPTLSIGAKTFLDCKKVSATQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZ67</accession>
    <name>A0A9J7GZ67_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100767051</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300118.1">
        <property type="nucleotide sequence ID" value="XM_035444227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GZ67"/>
    <dbReference type="GeneID" id="100767051"/>
    <dbReference type="KEGG" id="cge:100767051"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000006">
        <property type="entry name" value="Zinc finger protein 184 (Kruppel-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000128">
        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000044">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001509">
        <property type="entry name" value="Zinc finger protein 616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="41"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035300118.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="73637" checksum="1F4D51963F44188A" modified="2023-06-28" version="1">MSSYLLSSLDQLYLRYHMCVSKGKTTAKQLTDIMNEYVDLVSFEDVTVNFTWEEWQNLDDAQRVLYRNVMLETYSSLASLGLCIPKPELIFKLEQGAEPWTAEESANQRLPGFCNVDGTIETNQKCQDRHLCQITASSHNRTTEETNGLRNNFYLCSMKISNFVVNNRDCSGVKPEELNEYQNTCLPSEPHGIYTLEQYNDCCIAGESLKCPEQFSQHSQIQTGQQDFEYNGKDTKEAKLLEKIISSNRLQMGLTLCKHNEYEQVSVKSDVMVKVGKATFDKSCNLTENQETYSGSKFYKCLESKETFTSKLDLTVHQRTHNQNKAYVCIQCEKLFSTKSSLTIHQRIHTGEKPYGCSECDKTFRQKSALIVHERTHTGEKPFECHECGKAFQHKWYLKMHQRTHTGEKPYQCKECGRAFLKKSYLKVHQGTHKSDKPYECEECGKTFHNRSYFNLHHRTHTGDKPYACNECGKAFYQKSDLRRHQRIHNGERLHECKECGKAFQNKSYLKTHQKVHTGEKPYECRECGKAFQNKSYLNKHQIIHTGEKPYECSKCGKTFQWKLVLSKHYRIHTGEKPYECIQCGKTFGYRSSLIVHELIHSGEKPYECNICRKTFSQKSNLMRHQGTHRHGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H5B5</accession>
    <name>A0A9J7H5B5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytosolic phospholipase A2 gamma isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Pla2g4c</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40427"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73003"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:40428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nematocyst</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035305081.1">
        <property type="nucleotide sequence ID" value="XM_035449190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H5B5"/>
    <dbReference type="GeneID" id="100754559"/>
    <dbReference type="KEGG" id="cge:100754559"/>
    <dbReference type="CTD" id="8605"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042151">
        <property type="term" value="C:nematocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000079">
        <property type="entry name" value="Cytosolic phospholipase A2 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF39">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0166">Nematocyst</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="6" id="KW-1053">Target membrane</keyword>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="12"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035305081.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="100172" checksum="90D1B71D7ED49B5D" modified="2023-06-28" version="1">MNPEESPKSQLSSTHERTGVYFATGFQKEEKAALTKRSPKVLEALQKLNIQADQAPVIAVLGSGGGLRAHIAYLGVLSEMKELGLLDAVTYLAGVSGSTWALSSFYINNGDMEGMEEELKQRYEENRWQFGESLEKAIQAARRENYSMTDFWAYFVVSRQIRELENSNLSSIKKLVEEGRLPYPIFAAIDGDLQPDWRKRKTQKSWFEFTPHHAGYPALGAYVPITEFGSRFENGKLVKSEPERDLTYLRGLWGSALADIEDIKKFICGEYLRATQGPKPRDILCKETHLPFASCLVVIASDPSKVIFSHAVSFETSLGNLRPCLRKLNKLNTIASGCIVPLNSLHFYPLADMLTDLRAKLKQGHLGAAGPSTYLEAPEMPVDEVLLDLVMAFVKDQNDPSIKDKLQALQQILSAERDEFGEQKYICLAEVVQNWNEISPKEQEQFLEYLLYCFMRTREFHEGMKNSSMNWVRGLLQDIFTFLSKTGICCWRWEWGTVYNFLYKNGNVTDEAMKSREFLHLVDAGLAINTPYPLVLPPAREAHLILSFDFSAGDPLETVRATANYCQCHAIPFPDVREDQLKEWAKAPESCYIFRGETGPVVMHFTLFNKDNCGDHIETWRKKYETMKLSDSYTPDLVTDLLRVSKENVKRNKDNILSEMQKVAGKTGNFLGTNKDCRRDTVQDVQSSRIVEIKISSNPDVTFKEPLKTGNLLGTNKDCQRDRVQDVQSSRTVEIKISNNTDITFKEPLHYLQSGHVLVDPPPVLSPESTISCSFVKKSSSFQGTVGILVYQGPSVHLAFLFSVPFNYALHRIEFALATITEPLSRNLERVFDDITQGNGSPELKAAKSELQTPQGTLKLEHDSLIIKATMSNIHVAKMDVVVETRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HAT0</accession>
    <name>A0A9J7HAT0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Plexin-C1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Virus-encoded semaphorin protein receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Plxnc1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Monomer. Homodimer. Interacts with SEMA7A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306582.1">
        <property type="nucleotide sequence ID" value="XM_035450691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766140"/>
    <dbReference type="CTD" id="10154"/>
    <dbReference type="OrthoDB" id="384877at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12789">
        <property type="entry name" value="RasGAP_plexin_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11246">
        <property type="entry name" value="Sema_plexin_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000033">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000043">
        <property type="entry name" value="Plexin C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000316">
        <property type="entry name" value="Plexin C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000797">
        <property type="entry name" value="Plexin C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000020">
        <property type="entry name" value="Plexin C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041853">
        <property type="entry name" value="Plexin-C1_Sema"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF4">
        <property type="entry name" value="PLEXIN-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039893977" description="Plexin-C1" evidence="16">
        <location>
            <begin position="35"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="949"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1089"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="17">
        <location>
            <begin position="1"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035306582.1"/>
        </source>
    </evidence>
    <sequence length="1572" mass="176219" checksum="398F8E9C5279EEEC" modified="2023-06-28" version="1">MEVSRRKVPPRPPCPAAPLPLIAYLLALAAPARGAEEPVWRSEQAIGAIAASRADGVFVASGSCLDQLDYSLKHRLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGATGLEGLLLTGWTFDRGACEVRPLGNLSRSSLRNATEVVSCHPQGSTAGVVYRAGGTDRWYLAVAATYVLPEPETANRCNPAASDRDTAIALKNTEERSLATQELGRLKLRGSAGSLHFVDAFLWNGSVYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQAALDCSHGHPDGRRLLLSSSLVEAMDVWAGVFSAATGEGQERRSPATTALCLFRMSEIQARARSCSWDFQATEHNCKKDDRPEQVQPIASSTLIHSDLTSVYGTMVMNRTVLFLGTGDGQLLKVVLGENLTSNCPEVIYEIKEETPVFYKLVPHPVKDIYIYLTAGKEVRRIRVANCSKRKSCSECLTAADPHCGWCLPLQRCTFQGDCTHAGSFENWLDISSGPKKCPKIQIIRNLRERTTVTIVGSFSAKHSECVVKNADTGKLLCQGRSQLNRTCACNIPSRQSYKDLKIVNATFFFPSWNLSERFNFTNCASLKECPACIGTGCAWCKPDQKCIHPFAACDPSDYERNQELCHVTVEKLPKASGGGGGVRENQSNRINQSSKVFYIKAIEPQKISTLGKSNVIVTGANFTQASNITMILSGTSTCDKDVIRVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGTCSSAGALSYIALPHCSLIVPATTWISGGQNITIMGRNFDVIDNLIISHELKGNINVSEYCTATFCRFLAPNLKSSKVRTNVAVKLRVQDTYLDCGTLQYLEDPRFTGYRVESEIDTELEVKIQKENDNFNISKDDIDITLFHGENKQFNCSFENITRNQDLTTILCKIKSIKNANSIATSSKKVRVKLGNLELYVEQESVPSTWYFLIALPVLLAIVIVVAVVVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFNTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKDKIFQAFLSKNGSPYGLQLNEIGLELQVGTRQKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYSDDHCHLILPDSEAFQVVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDSCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSLEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFDEKKKCKWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCI4</accession>
    <name>A0A9J7HCI4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vomeronasal type-2 receptor 116-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118239804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035309677.1">
        <property type="nucleotide sequence ID" value="XM_035453786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCI4"/>
    <dbReference type="GeneID" id="118239804"/>
    <dbReference type="KEGG" id="cge:118239804"/>
    <dbReference type="OrthoDB" id="9612721at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06365">
        <property type="entry name" value="PBP1_pheromone_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000024">
        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF403">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039948968" evidence="8">
        <location>
            <begin position="19"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="9">
        <location>
            <begin position="76"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035309677.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="60585" checksum="E62E05DF0233BBA6" modified="2023-06-28" version="1">MLILIFLLLLLNIPLLMARFIHPRCFWKMKQNKDKTEELKTGCIFLPSIVERPVEKQYFKDILNIQIPAENYKYALALAYTMDEVNRNPDLLPNRSLVFDFSESNCITVTRLYHLDRHMEENYGYFHNYSCQKDISCVVVFTGPNWETSVITESFVQLIMSQQVIQFTYGPFHQILSDRERFPYLYQMAPKDTSLAFAMVSVILHFSWNWVGLAISDNDQGTQFLSNLRSELGKSTVCFAFVNIIPINIRLYVSRAQVYYKQIETSSTNVVIIYGDPDSTLAVSFQMWQSRGLQRLWVIDSQWDMITSKRDFMLDSSHMTLSFAHHHGEISGFKNFVQTMNPLKYTDEYLARLEWMNFNCEVSTSNCKTLRNYSSNVSVDWLVIRTFDMAFNDNLYDIYNAVYALAHALNEMVIQQVDTQPMDNGKGYHSPCWKLNSLLKRTHFTNPVGDRVNLNQKEKSQKEYDIFQIWNFQHGLRFKVNLGKYSPYFPHGQQLHIYEDMIEFATGNRQVGLTKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JDF5</accession>
    <name>A0A9J7JDF5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ethylmalonyl-CoA decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enoyl-CoA hydratase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methylmalonyl-CoA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Echdc1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:59540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:85316"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:32131"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:32132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:61340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:61341"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.94" evidence="8"/>
    <dbReference type="RefSeq" id="XP_007651609.1">
        <property type="nucleotide sequence ID" value="XM_007653419.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254212.1">
        <property type="nucleotide sequence ID" value="XM_027398411.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JDF5"/>
    <dbReference type="GeneID" id="100764713"/>
    <dbReference type="KEGG" id="cge:100764713"/>
    <dbReference type="CTD" id="55862"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004492">
        <property type="term" value="F:methyl/ethyl malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000040">
        <property type="entry name" value="Ethylmalonyl-CoA decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF27">
        <property type="entry name" value="ETHYLMALONYL-COA DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027254212.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34023" checksum="C15C3A2C84A6A440" modified="2023-06-28" version="1">MFSWMSIMSTEMAKSLLTTSLSARTKLLQTGVSLYNTSHGFHEEEVKKILEQFPGGSVDLQKNQNGIGILTLNNPNKMNAFSGVMMLQLLERVIELENWTEGKGLIVRGAKNTFCSGSDLNAVKALSTSENGVALSMFMQNTLTRFMRLPLISVALVQGWAMGGGAEFTTACDFRLMTMESVIRFVHKEMGIVPSWGGASRLVEIIGSRQALKVLSGTLKLDSKKALNMGFVDEVLQSSDEAKALEEAQEWLEQFVSGPPEVIRGLKKSVCSGRELYLEEALQNERDVLGTLWGGPANLEAIAKRGKHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JEH1</accession>
    <name>A0A9J7JEH1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Msx2-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SMART/HDAC1-associated repressor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">SPEN homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Spen</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255722.1">
        <property type="nucleotide sequence ID" value="XM_027399921.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100754338"/>
    <dbReference type="KEGG" id="cge:100754338"/>
    <dbReference type="CTD" id="23013"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060816">
        <property type="term" value="P:random inactivation of X chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12348">
        <property type="entry name" value="RRM1_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12349">
        <property type="entry name" value="RRM2_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12350">
        <property type="entry name" value="RRM3_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12351">
        <property type="entry name" value="RRM4_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21543">
        <property type="entry name" value="SPOC_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000088">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000118">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000143">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000150">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000002">
        <property type="entry name" value="Spen family transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049095">
        <property type="entry name" value="MINT_MID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049094">
        <property type="entry name" value="MINT_RAM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049093">
        <property type="entry name" value="MINT_RID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034172">
        <property type="entry name" value="SHARP_RRM1"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="3617" mass="395990" checksum="658504EB1C790D4A" modified="2023-06-28" version="1">MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRGREVSGFRGSGGGPAYGPPPSLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGAFDRTRHYDQDYYRDPRERTLQHGLYYTSRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERSYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSESISSSSSTSTDSSDSSSTSSGDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFKKFGKVTSVQIHGASEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWIGPETESENEFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAFLQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCMEKSGQDIRDFYEMLTERREERRGSYDYSQDRTYYESVRTPGTYPEDSRRDYPARGRDFYSEWETYQGEYYESRYYDDPREYREYRSDPYEQDIREYSYRQRERERFESDRDRDHERRPIERSQSPVHLRRPQSPGVSPAHSERLPSDSERRLYRRSSERSGSCSSVSPPRYDKLEKVRLERYTKNEKTDKERIFDPERMERERRIIRKEKVEKEKPDRQRRKGKGHSPSSQSSETEQENDGEQSPEKTRSSTKLSREKTDKEGLAKNRLELMPCVVLTRVKEKEGKVIDHPLTEKVKARFDHDTVKPSALGQKSQASQMEASKSDSSAVESARGKAPREKALSSHAEVVDKEGRPKLRKHLKPEQPPEGLSALDLEKLEARKRRFAESSLKAEKQKPEVKKSNPETEDTRVLLKKQPDVPRGGESDRKPVRKEILKRESKKTKLDRLNSAPSPKDCQEPASASSGSGSRPSSEVHTGLGDPTHGSVESQEAQPKKAIPSKPQLKQLQLLDNQGPEKEEVRKNYCRLRDEPSEHKAGQEKPHTVNAEEKLGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKNDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEESERTSCSPSVRHGSFHEDDDTLGSPRLMSVKGSPKVDVAVREDPLKFNPYESSKREQVADMAKIKLSVLNSEDEPNRWDPQMKQDPSRVDVSFPNSIIKRDSLRKRSIRDLEPGEVPSDSDEDAEHKSQSPRASTFYDSPRLSFLLRDRDDKIRERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKDDHREEEQERQELFASRFLHSSIFEQDSKRLQHLERKGEESDFPPGRLYNRQASEGASSTGDSVQEPVVLFHSRFMELTRMQQKEKEKDQKPKEAEKHEDPETVAKTPEPATETKELEPKAPVSVGLPVVTPVTPEPASSAPEKAEKTAEAPLLAGEKPVEPAPLLEEVKSACEPVPAPVEQPKQVDLTPGEGTSESTAVAPLATRESSSTDAIPCVDAEPLTPGTAISKAESNVDPKPSSPQPLSKQAQKSEEAEEPKVEKPDAAPGIEPSATQKAEVMPEVQPPASEDVEANPPVAARDKKTNKNKRSKTPVQAAATSIVEKPVTRKSERIDREKLKRSSSPRGEAQKLLELKVEAEKITRAASKSSAGDPELPEPSLPLSRTRRRNVRSVYATMGDHESRSPAKEPAEQPRVTRKRLERELQEATVAPTTPRRGRPPKTRRRVEDDEEHETKEPAETPKPAEGWRSPRSQKSAATGGPHGKRGRNDQKAEAAAESSAQVNTRESNAKSRGDKEAASDSKRDRRDTSTDKNGPDPFPVEAVENKPPPEKGTKSKRGRARNTRSAMDRAAHLRSLDMATRAAGQAVDKEAGLVAISPEKNESPPKESGSSCQLKSDPVDPKKAAEKDDASTSTVTPEATQLAKQMELEQAVENIAKLTEPSSRTADKGPATGTSEGPAPEDGHKPAHQASETELAAAIGSIISDNSGEPENLSASASFPTGSQAHPQEGMEPGPTGATSGDSEANAVSQSSGSQLGASVPAAGSADTKETRENSSDAVQEARGSKVEVTPPRRDKGRQKTTRSRRKRNTNKKGIQTAIEPRASEAEQAQSESPAANEATAAPPEALQEEQQSENLPSTPPQECTSDPSKTPPAESLCQESSVEETTPCKAPAPPDLPPLSQPSLVGDEPQARFKVHSIIESDPVTPPSDSSIPPPTIPLVTIAKLPPPVIPGGVPHQSPPTKVTEWITRQEEPQTQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATGVTSTSVTAAIAEPVSAAPCLHEAPVPPGEPKHLPLEEKSATPVSNASDTQPSEVPVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVATLKGLVSTPAGPVNLLKGPVNVLTGPVNVLTTPVSATVGTVNAAPGTVNAAAGAVTAACGVTATTGTAAVTGAAVTVPPTKGKQRSSSSENSRFHPGSMSVIDERPADTGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTPSQSAPKGPQTPSAFANMATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGPTLTPHHPPALPSKLPTEVNHVPSGPSTPADRTISHLAATKPDTHSPRPSGPAPGPFPRACHPSSTTSTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLGHLSQGEVRMNTPTLPSITYSIRPETLHSPRAPLQPQQIEARAPQRVGTPQPATAGVPALATQHPPEEEVHYHLPVARAAAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSDQPRAAEGAVKVPPANKAPQQLVKETVKTSDAKAIPVPVPAPAPAPGPVPTPAPTPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHAPAQLTHTQFPVASSISLPSRTKTSAQGPPEGEPLQSTQPTQSAPATQATQPAPSAPSCQPSQLNQPSQPLSSKMPQVSQEAKGTQTGGIEQPRLSAVPASRPPEPHVQVQKAPVETGQPAHPSPVSVSTKTDLPNPLPSQAAPKQPLFVPVASGASTPPGLALPHTEAQSAPKQDSSLHLTSQRPVDMVQLLKQKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPLSEGGPPLRIAQRMRLEASQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFITYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIVIASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JEW1</accession>
    <name>A0A9J7JEW1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cyclic GMP-AMP phosphodiesterase SMPDL3A</fullName>
            <ecNumber evidence="4">3.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Acid sphingomyelinase-like phosphodiesterase 3a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Smpdl3a</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling. Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA. Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2',3'-cGAMP + H2O = 5'-pGpA(2'-5') + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78339"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:143093"/>
            <dbReference type="ChEBI" id="CHEBI:228270"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:78340"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5'-pGpA(2'-5') + H2O = 5'-GpA(2'-5') + phosphate</text>
            <dbReference type="Rhea" id="RHEA:78343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:228270"/>
            <dbReference type="ChEBI" id="CHEBI:228271"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:78344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23681"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer. Homodimer; homodimerizes following 2',3'-cGAMP-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027254243.2">
        <property type="nucleotide sequence ID" value="XM_027398442.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293645.2">
        <property type="nucleotide sequence ID" value="XM_027437844.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JEW1"/>
    <dbReference type="GeneID" id="100753337"/>
    <dbReference type="KEGG" id="cge:100753337"/>
    <dbReference type="CTD" id="10924"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160049">
        <property type="term" value="P:negative regulation of cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000044">
        <property type="entry name" value="acid sphingomyelinase-like phosphodiesterase 3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF24">
        <property type="entry name" value="ACID SPHINGOMYELINASE-LIKE PHOSPHODIESTERASE 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039921661" description="Cyclic GMP-AMP phosphodiesterase SMPDL3A" evidence="20">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="21">
        <location>
            <begin position="37"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="22">
        <location>
            <begin position="305"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00077596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027254243.2"/>
        </source>
    </evidence>
    <sequence length="518" mass="57860" checksum="8A08CF9DBE25E262" modified="2023-06-28" version="1">MAFLATFLCCLLAAWPRHPGLGVPLAPAGSTPAVGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVMCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTIQNLFPSLQVFPALGNHDYWPQDQLPIATSKVYSAVADLWKPWLDEEAISTLRKGGFYSQKVANNPDLRIISLNTNLYYGPNVMTLNKTDPANQFEWLENTLNSSLQNKEKVYIIAHVPVGYLPYATDTPAVRQYYNEKLVDIFRKYSSVIAGQFYGHTHRDSLMVLSDRQGSPINSAFVAPAVTPVKGVLQKETNNPGVRLFQYKPDDYALLDMLQYYLNLTEANLKGESNWTLEYILTQTYGIADLQPRSLHGLAKQFATIDSKQFLKYYHYFFVSYDSSVTCDQKCKTLQICAIMNLDSISYDDCLKQHFMKHSHEGGSEAFTLTSPWTRWNGAGDNVQSSVCYRAHLSSFLLSSQIAAKGRQSTAATSRGRFYSPDNSLITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JSD1</accession>
    <name>A0A9J7JSD1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein PRRC2C isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Prrc2c</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027273002.1">
        <property type="nucleotide sequence ID" value="XM_027417201.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100750698"/>
    <dbReference type="KEGG" id="cge:100750698"/>
    <dbReference type="CTD" id="23215"/>
    <dbReference type="OrthoDB" id="1939715at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009738">
        <property type="entry name" value="BAT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033184">
        <property type="entry name" value="PRRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038">
        <property type="entry name" value="BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038:SF6">
        <property type="entry name" value="PROTEIN PRRC2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07001">
        <property type="entry name" value="BAT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAT2 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1652"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1776"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1846"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1976"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2227"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2287"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2643"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2798"/>
            <end position="2870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
            <begin position="342"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="812"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
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        </location>
    </feature>
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        <location>
            <begin position="928"/>
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        </location>
    </feature>
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        <location>
            <begin position="941"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="987"/>
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        </location>
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        <location>
            <begin position="1007"/>
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        <location>
            <begin position="1045"/>
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    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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    </feature>
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            <begin position="2248"/>
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            <begin position="2290"/>
            <end position="2304"/>
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        <location>
            <begin position="2654"/>
            <end position="2677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027273002.1"/>
        </source>
    </evidence>
    <sequence length="2870" mass="313730" checksum="BC426925552A8515" modified="2023-06-28" version="1">MSEKSGQSTKAKDGKKYATLSLFNTYKGKSLETQKTTVAARHGLQSLGKVGISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKAPEVSPAQPKPGVAAPPEVAPAPKSWASNKQGGQGDGIQVNSQFQQEFPSLQAAGDQEKKEKETNDENYGPGPSLRPPNVACWRDGGKSAGSPSSDQDEKQLGQDESMSITSEQNDILKVVEKRIACGPPQAKLNGQQPTLASPYRAMMPPYMFQQYPRMAYPPLHGPMRFPPSLSETNKGLRGRGPPPSWASEPERPSILSASELKELDKFDNLDAEADEGWAGAQMEVDYTEQLNFSDDDEQGSSSPKENSSEDQSSKTPESTENRKEVDEASGTKSSSQIPAQPPVAKSPYGKGPPFNQERGPSSHLPPPPKLLAQQHPPPPDRQVPGRQGPFPSKPQVPDNDEIWKQRRKQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKQLDEKFGIIEKQPSPEELREREREKEREREKELEKEREQERERERERELEKEREKQKEMEKERQQQKELEQQREKEQELQRVREEEKEVELKEKEKEEKVEPQEPILEPMAEKQESESNCNKEEEPIFTRQDSSRSEKETTQMVQEAEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQQGVLPQTVPSQPSNGSVPPPPHRPLYQPMQPHPQHLASMGFDPRWLMMQSYMDPRMISGRPAMDIPPIHPGMIPPKPLIRRDQMEGSPNSSESFEHIARSARDHGISLSEPRMMWGSDPYHAEPQQAATPKSAEEPRDARTEPALDHEQITAAYPVEHSHLETHSKTDVARDSAETEGHKYLSKSVEDVRPLRADTNNQSACFEVIDQKSLPTPPEERISALESQPARKRSVSHGSNHTQKADEQRSEPSVSITKVTSRCIDSKETVEKPEEKPRKDSFLRSSEGPKPEKIYKSKSETRWGPRPSSNRREEGNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTERVVKTEKTEKKDLPPPLPPPAPVQPQPLVPPPVQPEPEKLPSTETSASAQKPSQDNEKPLEPVPSVQVEPAVKTGNQQSIAAPTVKEEKQPEKVISKDVGVERLRPDSRPPVKKESPLPPRTYWKDARDRDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGRGHTRDYPQYRDSKPRTEHGPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDSEVHESASDKDSLSKGKFPKREERAENKKPMKPQSFKPENHVRIDNRPLEKPYIRDEDKSKPGFLPKGEPTRRGRGGTFRRGGRDPGSRPSRPATLRRPAYRDNQWNPRQAEPPKPEDGEPPRRHEQFMPIPADRRPPKFERKFDPARERPRRQRPTRPPRQDKPPRFRRLREREAASKTGEVLVTTNGTVNNVVQEPVNPPGDVSGNKTPDLSNQNSSDQANEEWETASESSDFNERRERDEKKNADVSSQTVVKAGENVLPPKREIAKRSFSSQRPGVDRQNRRGNNGPPKSGRNFSGPRNERRNGPPSKSGKRGPFDDQSSGTAGVDPVNGNSAHHQEGAPNGAGQKNPKDATGKKREDTKPGPKKTKEKVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQQKRLQDEERRKKEEQVVQVWNKKNVNEKGRSQASKLPPRFAKKQATGTQQAQAPASAPAPVSSSAAVLPPPAASVPATAPAPAPVPVLASATALVPASAPAQVLTSSPAPVPASASTPVPVSTSSALTASSSPQVSVPAPTPILASASATASVPILTSASIPILASALAPASVSSPTPVVSAPAGPTISTPTAPTPAPVPAPAASVPLAPASTTTTAPAPAPAPAPPAQTQTQTHKPVQSPLPPPTSSSKQPPPSIRLPSAQTSNGTDYVATGKSIQAPQSHGSLTAELWDNKVAAPAVLNDISKKLGPISPPQPPSVSAWNKPLTSFGSATSSEGTRNGQEAGVEIGIDTIQFGAPASNGNENEVVPVLSEKPTDKVPEPKEQRQKQPRAGPIKAQKLPDLSLVENKEHKPGPIGKERSLKNRKVKDAQQAEPEGQEKPSPAVVRSTDPGTSKETKAVSEMSAEIGAMISVSSAEYGTDAKESVTDYTTPSSSLPNTVATNNAKMEDTLVNNVPLPNTLPLPKRETIQQSSSLTSVPPTTFSLTFKMESARKAWENSPNIREKGSPVTSTAPPIVSGVSSSASGSSTANYNSFSSASMPQIPVASVTPTASLSGAGTYTTSSLSTKSTTTSDPPNICKVKPQQLQTSSLPSASHFSQLSCMPSLIAQQQQSPQVYVSQSAAAQIPAFYMDTSHLFNTQHARLAPPSLAQQQGFQPGLSQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPAVSQAQELFSSSIQPYRSQPAFMQSSLSQPSVVLSGTAIHNFPAVQHQELAKAQSGLAFQQTSNTQPIPILYEHQLGQASGLGSSQLIDTHLLQARANLTQASNLYSGQVQQPGQTNFYNTAQSPSALQQVNYGMVTVPLPASQLSLTNFGSTGQPLIALPQTLQPQLQHTTPQAQAQSLSRPAQVSQPFRGLIPAGTQHSMMATTGKMSEMELKAFGGGIDIKPGTPPIGGRSTTPTSSPFRATSTSPNSQSSKMNSIVYQKQFQSAPATVRMTQPFPAQFAPQILSQPNLVPPLVRAPHTNTFPAPVQRPPMALASQMPPPLTTGLMSHARLPHVARGPCGSLSGVRGNQAQAALKAEQDMKAKQRAEVLQSTQRFFSEQQQSKQIGGKGQKVDSDSSKSPETLTDPPGACQEKVEEKPPPAPTITTKPVRTGPIKPQAIKTEETKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JTC9</accession>
    <name>A0A9J7JTC9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100760939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276943.1">
        <property type="nucleotide sequence ID" value="XM_027421142.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JTC9"/>
    <dbReference type="GeneID" id="100760939"/>
    <dbReference type="KEGG" id="cge:100760939"/>
    <dbReference type="OrthoDB" id="9615015at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15945">
        <property type="entry name" value="7tmA_OR5C1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027276943.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34619" checksum="2BF267FBF0CD16E3" modified="2023-06-28" version="1">MEVGNCSATEFLLLGITNNPVMKVILFTAFLIVYLIILIENLGMIALIRMDPQLHTPMYFFLSHLSFSDICYSTAVGPKMLVGLVAKSNTIPFVGCALQFFIFCIFTDAECVLLAVMAFDRYKAISNPLLYAVDMSRLVCYQLLAVVYLVGMVDALTHTTLTFRLCFCGSKEINHFFCDVPPLLLLSCSDTEVNELVIFTLFGFIELSTISGVLVSYGYIISSVLKIHSAEGRFKAFSTCTSHLTAVAIFQGTMLFMYFRPSSAYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKSSAKKHLRGRVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JWX3</accession>
    <name>A0A9J7JWX3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">StAR-related lipid transfer protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">START domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20 21" type="primary">Stard3</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19 20 21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19 20 21">17A/GY</strain>
            <tissue evidence="19 20 21">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts (via the MENTAL domain) with STARD3NL. Interacts (via phosphorylated FFAT motif) with VAPA (via MSP domain). Interacts (via phosphorylated FFAT motif) with VAPB (via MSP domain). Interacts (via phosphorylated FFAT motif) with MOSPD2 (via MSP domain); this interaction allows enrichment of MOSPD2 around endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STARD3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279952.1">
        <property type="nucleotide sequence ID" value="XM_027424151.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279953.1">
        <property type="nucleotide sequence ID" value="XM_027424152.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279954.1">
        <property type="nucleotide sequence ID" value="XM_027424153.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JWX3"/>
    <dbReference type="GeneID" id="100759029"/>
    <dbReference type="KEGG" id="cge:100759029"/>
    <dbReference type="CTD" id="10948"/>
    <dbReference type="OrthoDB" id="5912992at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08906">
        <property type="entry name" value="START_STARD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000014">
        <property type="entry name" value="stAR-related lipid transfer protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029867">
        <property type="entry name" value="STARD3_MLN64_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF2">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51439">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="17">
        <location>
            <begin position="43"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="16">
        <location>
            <begin position="245"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027279952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027279953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027279954.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="50189" checksum="463FBAFEA501CD9A" modified="2023-06-28" version="1">MSKLPSELACDLERSLPALASLGTSLSHSQSFIPPPLEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRRNLEQEIIHYSFQNSFFDIFILAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQAAVARGPLLFSSALSEGQFYSPPESFAGSDNESDEEVPGKKSFSAQEREYIRQGREATAVVDQILAQEENWKFERSNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEESTLVSYDVSSGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATTHCAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFIWILNTDLKGRLPRYLIQQSLAATMFEFAFHLRQRIGELGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K360</accession>
    <name>A0A9J7K360_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-CpG-binding domain protein 3-like 5 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC103158728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027289529.1">
        <property type="nucleotide sequence ID" value="XM_027433728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K360"/>
    <dbReference type="GeneID" id="103158728"/>
    <dbReference type="KEGG" id="cge:103158728"/>
    <dbReference type="OrthoDB" id="9621509at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032343">
        <property type="entry name" value="MBD2/MBD3_p55-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025884">
        <property type="entry name" value="MeCpG-bd_2/3_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14048">
        <property type="entry name" value="MBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MBDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyl-CpG-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-CpG binding protein 2/3 C-terminal" evidence="1">
        <location>
            <begin position="86"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027289529.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24149" checksum="044C6A259265D275" modified="2023-06-28" version="1">MIPQDLHNTGTQFAQKKVKAKHRFCVTPVIPVRMTSSIFPRPVTRITSHPKNIIKYRKRLEENLEKPRQLCAFKRLQEYLLQDSKGGIQAEAKVSSGANNLHTSPHFTSIPPLSSENIVQVQLSPSSFSQGVTLPVALPPLPSLSSQVVTTTDIRRQAQKVDIIRERLAALLESDRLARQAENVAEQRRRVFWKLNEKKKKLENTRVANSASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3J9</accession>
    <name>A0A9J7K3J9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAU2 chromatid cohesion factor homolog</fullName>
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        <alternativeName>
            <fullName evidence="9">Cohesin loading complex subunit SCC4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Mau2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307748.1">
        <property type="nucleotide sequence ID" value="XM_035451857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3J9"/>
    <dbReference type="GeneID" id="100763469"/>
    <dbReference type="KEGG" id="cge:100763469"/>
    <dbReference type="CTD" id="23383"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035307748.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47329" checksum="163B35B433B19E01" modified="2023-06-28" version="1">MERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4V5</accession>
    <name>A0A9J7K4V5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium homeostasis modulator protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Calhm3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CALHM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297673.1">
        <property type="nucleotide sequence ID" value="XM_035441782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K4V5"/>
    <dbReference type="GeneID" id="100753966"/>
    <dbReference type="CTD" id="119395"/>
    <dbReference type="OrthoDB" id="5978124at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029569">
        <property type="entry name" value="CALHM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261:SF7">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14798">
        <property type="entry name" value="Ca_hom_mod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035297673.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="42823" checksum="C5DE3262E4285123" modified="2023-06-28" version="1">MLTEAKCSPGPGAGCIWPVWEIHPPHPGKAANRQRSTQAAAVMDRFRMLFQNLQSSSESVMNGICLLLAAVTVKMYSSFDFNCPCLARYNALYGLGLLLTPSLALFLCGLLVNRQSVVMVEEWRRPAGHRKKDLGIIRYMCSSVLQRALAAPMVWILLALLDGKCFVCAFSNSVDPEKFLDFANMTPSQVQLFLAKVPCKEDEMVKDSPARKAVSRYLRCLSQAIGWSITLLLIVVAFLARCLRPCFDQTVFLQRRYWSNYVDLEQKLFDETCCEHARDFAHRCVLHFFASMQSELRALGLHRGGIPESQELPEPPEDLDGGSGKAHLRAISSREQVDHLLSTWYSSKPPLDLAASPKLWRPGLNHRASIAAPGTKLCHQVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K9V5</accession>
    <name>A0A9J7K9V5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein PBDC1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pbdc1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035305707.1">
        <property type="nucleotide sequence ID" value="XM_035449816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K9V5"/>
    <dbReference type="GeneID" id="100763510"/>
    <dbReference type="CTD" id="51260"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035305707.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18449" checksum="1A8B60DB0ECED97F" modified="2023-06-28" version="1">MAWAIRAMQHAEVYYKLISSVDPQFLKLTKVDDQIYSEFRGNFEKLRVDVLDPEELKSESAKEKWRPFCLKFEGIVEDYNYGTLLRLDCSQGYTEENTIFAPRIQFFAIEIARNREGYNKAVSISVQDKEGEKGADNEEEESEKGADSGGEKEEGVNREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KCY5</accession>
    <name>A0A9J7KCY5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17 18">Zinc finger protein 54 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17 18 19 20 21 22" type="primary">LOC100759173</name>
    </gene>
    <organism evidence="15 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16 17 18">17A/GY</strain>
            <tissue evidence="16 17 18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016836032.1">
        <property type="nucleotide sequence ID" value="XM_016980543.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289826.1">
        <property type="nucleotide sequence ID" value="XM_027434025.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292679.1">
        <property type="nucleotide sequence ID" value="XM_035436788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292680.1">
        <property type="nucleotide sequence ID" value="XM_035436789.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292681.1">
        <property type="nucleotide sequence ID" value="XM_035436790.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292682.1">
        <property type="nucleotide sequence ID" value="XM_035436791.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292683.1">
        <property type="nucleotide sequence ID" value="XM_035436792.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309699.1">
        <property type="nucleotide sequence ID" value="XM_035453808.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309700.1">
        <property type="nucleotide sequence ID" value="XM_035453809.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309701.1">
        <property type="nucleotide sequence ID" value="XM_035453810.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309703.1">
        <property type="nucleotide sequence ID" value="XM_035453812.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309704.1">
        <property type="nucleotide sequence ID" value="XM_035453813.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309705.1">
        <property type="nucleotide sequence ID" value="XM_035453814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KCY5"/>
    <dbReference type="GeneID" id="100759173"/>
    <dbReference type="KEGG" id="cge:100759173"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003729">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000116">
        <property type="entry name" value="Zinc finger protein 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001530">
        <property type="entry name" value="Zinc finger protein 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000367">
        <property type="entry name" value="Zinc finger protein 572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
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        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
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        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027289826.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035309699.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035309700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035309701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035309703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035309704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035309705.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="64627" checksum="1BD7E7FEF8A98AB0" modified="2023-06-28" version="1">MGSSPVSMSQGVLTFRDVAVDFSQEEWECLDSGQRALCIDVMLENYSNLVFVEKYQKSDPVRHHVKTEKESCQCNELGKVLHDPSTCSHHRTSETTENSKNYTCSNHSDASGDSSDPDRDESMYTGEEPCRSIDSEKFLNVSSNFTEVQRLCTADKEHRQEEGDDTLSSATRILHRAVYIEENPYQCGNCKKCFRSASYLNDHERIHTGIKPCQSNISEQSFTQHSSCKIHQSLHIVDKPYTCMECDMSLTWDSQFRRLKRFHTVERPYCCMQCNKSYTQVSRLRAHQRICTTERPYKCMECDKSFTRNSGLRRHRRVHTRERPYKCMECDKSFICDSKLRIHERVHTGERPYKCKECDKSFTHNSQLKIHERVHTGERPYNCIDCGKSFTQQAHLKKHHTVHTGEKPYKCMQCDKSFFCDSDLRKHQRVHTGEKPYKCMECDKSFTQNSHLRTHQRIHTGEKPYKCMECDKSFTQDSHLRTHQSIHTGERPYKCKACDKSFTWKSQLRTHERVHTGVKPYKCMQCNKCFTRILLLRAHQRICTRENLTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KD33</accession>
    <name>A0A9J7KD33_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Myelin-associated glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC113831770</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="20">Monomer and homodimer. Interacts (via the first three N-terminal Ig-like domains) with RTN4R and RTN4RL2. Interacts with isoform 2 of BSG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305435.1">
        <property type="nucleotide sequence ID" value="XM_035449544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KD33"/>
    <dbReference type="GeneID" id="113831770"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035749">
        <property type="term" value="C:myelin sheath adaxonal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043220">
        <property type="term" value="C:Schmidt-Lanterman incisure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905576">
        <property type="term" value="F:ganglioside GT1b binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20987">
        <property type="entry name" value="IgC2_CD33_d2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05712">
        <property type="entry name" value="IgV_CD33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000475">
        <property type="entry name" value="myelin-associated glycoprotein isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000663">
        <property type="entry name" value="myelin-associated glycoprotein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000743">
        <property type="entry name" value="myelin-associated glycoprotein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF107">
        <property type="entry name" value="MYELIN-ASSOCIATED GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 24" id="KW-0732">Signal</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039888342" description="Myelin-associated glycoprotein" evidence="24">
        <location>
            <begin position="20"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="239"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="329"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_035305435.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="69307" checksum="715C15B402C8B822" modified="2023-06-28" version="1">MIILTTLPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIINTPNIVVPPEVVAGSEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREEEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAESLYLDLEEVTPGEDGVYACLAENSYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLLLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTLRGQAQTPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSGGDNPHVLYSPEFRISGAPDKYESKRRLGSERRLLGLRGEPPELDLSYSHSDLGKQPTKDSYTLTEELAEYAEIRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KFQ4</accession>
    <name>A0A9J7KFQ4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Myosin-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100771006</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309303.1">
        <property type="nucleotide sequence ID" value="XM_035453412.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311957.1">
        <property type="nucleotide sequence ID" value="XM_035456066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771006"/>
    <dbReference type="KEGG" id="cge:100771006"/>
    <dbReference type="OrthoDB" id="10254995at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098871">
        <property type="term" value="C:postsynaptic actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14921">
        <property type="entry name" value="MYSc_Myh11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000003">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.270.10:FF:000001">
        <property type="entry name" value="Myosin heavy chain, non-muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000017">
        <property type="entry name" value="myosin-10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="85"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1359"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1359"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035309303.1"/>
        </source>
    </evidence>
    <sequence length="1421" mass="163374" checksum="2E5D49E6B2102EF8" modified="2023-06-28" version="1">MAQKGQLSDDEKFLFVDKNFINSPMAQADWVAKKLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKMKSDLLLESFNSYTFLSNGFVPIPAAQDDEMFQETLEAMSIMGFNDEEQLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGINVTDFTRAILTPRIKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFTSTLEAMEEGKKRLQKEMEGLSQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELDDARASRDEIFATSKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNTLQDEKRRLETRIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSAAQKNESARQQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEVLLQVEDERKMAEQYKEQAEKGNAKVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3GRW9</accession>
    <name>G3GRW9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIKEN cDNA 6430548M08 gene</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3 7 8 9">Uncharacterized protein KIAA0513</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7 8 9" type="primary">Kiaa0513</name>
        <name evidence="3" type="ORF">I79_000264</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7 8 9">17A/GY</strain>
            <tissue evidence="7 8 9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="EGV94113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </feature>
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            <begin position="46"/>
            <end position="57"/>
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        <location>
            <begin position="74"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF12335"/>
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    </evidence>
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            <dbReference type="EMBL" id="EGV94113.1"/>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSCGRP00001011323.1"/>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Myomorpha</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CHO K1 cell line</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
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        <property type="protein sequence ID" value="EGV96568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ERE63511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF41">
        <property type="entry name" value="PPP1R2C FAMILY MEMBER C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ERE63511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027289052.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20458" checksum="775FAA2ED1273382" modified="2011-11-16" version="1">MATSTTSHRPIKGILKNKSSTSSVEDSAQPSGRAGTQELQRKKSQKWDESNILATHYPSYKDYDLMKMNEPGNPYASVPHDGEDGMSEVQGKEAMTPDTLAKKLAATDTFGTSHQGEEQGSSGAHSSKFFLDKQERQRQFELKRKLHYNEGLNIKLARQLISEELQSEVEDDENQPRLHSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3GTA8</accession>
    <name>G3GTA8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 11">Ankyrin repeat domain-containing protein 34C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ankrd34c</name>
        <name evidence="7" type="ORF">H671_4g11921</name>
        <name evidence="6" type="ORF">I79_000885</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000018">
        <property type="protein sequence ID" value="EGV94495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE674533">
        <property type="protein sequence ID" value="ERE76338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640862.1">
        <property type="nucleotide sequence ID" value="XM_007642672.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266771.1">
        <property type="nucleotide sequence ID" value="XM_027410970.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GTA8"/>
    <dbReference type="PaxDb" id="10029-XP_007633426.1"/>
    <dbReference type="GeneID" id="100757468"/>
    <dbReference type="KEGG" id="cge:100757468"/>
    <dbReference type="CTD" id="390616"/>
    <dbReference type="eggNOG" id="ENOG502QW3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQQNTVF"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF6">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 34C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV94495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ERE76338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027266771.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="58126" checksum="1AE22C976D3E4325" modified="2011-11-16" version="1">MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRQSPPLCASPSDIELKAPSLDSPPSEKDDDFFILQSGHQSGCSTSKALNEPGSPTRKVSSLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDETHGTSTDNEIVRSINDISFPKRGPLSRANSIDSKDCTLFPTVQEQVLKVPASAPATWKAAYEKGQAPHPRLARRGTTLPVDQEKAGMCPPGPSALKDPASLKLLENDLYDLDVQPGADPPNTMSLESAKGPLDRKKLNSSHLSLFHGSRECLDAVPSTSPSSVRRRPPHLLERRGSGTLLLDRIAHTRPGFLPPLNVNSNPPIPDIRASSKPAAPLAGGLKSMVPIAPNSPKRVDLRSKKKLLRRHSMQIEQMKQLSDFEEIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3GXC7</accession>
    <name>G3GXC7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine rich repeat containing 45</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6 10">Leucine-rich repeat-containing protein 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Lrrc45</name>
        <name evidence="6" type="ORF">I79_002417</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <authorList>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
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        </subcellularLocation>
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        <location>
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        <source>
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    </evidence>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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            <strain evidence="16">CHO K1 cell line</strain>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000060">
        <property type="protein sequence ID" value="EGV98857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE668644">
        <property type="protein sequence ID" value="ERE83685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497041.1">
        <property type="nucleotide sequence ID" value="XM_003496993.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257992.1">
        <property type="nucleotide sequence ID" value="XM_027402191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GXM5"/>
    <dbReference type="STRING" id="10029.G3GXM5"/>
    <dbReference type="PaxDb" id="10029-XP_007624618.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014880.1">
        <property type="protein sequence ID" value="ENSCGRP00001010656.1"/>
        <property type="gene ID" value="ENSCGRG00001012490.1"/>
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    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="GeneTree" id="ENSGT00530000063583"/>
    <dbReference type="OMA" id="TLWHPHE"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1990403">
        <property type="term" value="P:embryonic brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV98857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE83685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027257992.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="65473" checksum="B090F160A04DE0B7" modified="2011-11-16" version="1">MSAAIAALAASYGSGSGSESDSDSEGSRCPLPAADSLMHLTKSPSAKPSLTVAVDSAPEVAVKEDLETGVHLDPAIKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEERPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSSVPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVVTCGWDGLIKLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3H0C0</accession>
    <name>G3H0C0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cellular retinoic acid binding protein I</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5 9">Cellular retinoic acid-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Crabp1</name>
        <name evidence="5" type="ORF">I79_003575</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000090">
        <property type="protein sequence ID" value="EGW03752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497951.1">
        <property type="nucleotide sequence ID" value="XM_003497903.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270927.1">
        <property type="nucleotide sequence ID" value="XM_027415126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H0C0"/>
    <dbReference type="SMR" id="G3H0C0"/>
    <dbReference type="STRING" id="10029.G3H0C0"/>
    <dbReference type="PaxDb" id="10029-XP_007616062.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031096.1">
        <property type="protein sequence ID" value="ENSCGRP00001026850.1"/>
        <property type="gene ID" value="ENSCGRG00001024040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755827"/>
    <dbReference type="KEGG" id="cge:100755827"/>
    <dbReference type="CTD" id="1381"/>
    <dbReference type="eggNOG" id="KOG4015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MPNFAGN"/>
    <dbReference type="OrthoDB" id="195110at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19460">
        <property type="entry name" value="CRABP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGW03752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027270927.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15592" checksum="A3DB0494D88943B4" modified="2011-11-16" version="1">MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLPTWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3HB74</accession>
    <name>G3HB74_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amine oxidase</fullName>
            <ecNumber evidence="7">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">LOC100763954</name>
        <name evidence="12" type="ORF">I79_007695</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="7"/>
    <dbReference type="EMBL" id="JH000263">
        <property type="protein sequence ID" value="EGV91792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003501351.3">
        <property type="nucleotide sequence ID" value="XM_003501303.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284262.1">
        <property type="nucleotide sequence ID" value="XM_027428461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HB74"/>
    <dbReference type="SMR" id="G3HB74"/>
    <dbReference type="STRING" id="10029.G3HB74"/>
    <dbReference type="GlyGen" id="G3HB74">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007618213.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007222.1">
        <property type="protein sequence ID" value="ENSCGRP00001004772.1"/>
        <property type="gene ID" value="ENSCGRG00001006146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763954"/>
    <dbReference type="KEGG" id="cge:100763954"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183207"/>
    <dbReference type="OMA" id="IYNQNHP"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052597">
        <property type="term" value="F:diamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000009">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000007">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000009">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF22">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732128" description="Amine oxidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="10">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="11">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="9">
        <location>
            <begin position="299"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV91792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027284262.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="79820" checksum="BDE955BB1EC61E26" modified="2011-11-16" version="1">MGLAQRSLALGCMAIILVLQMTMAEYPNWMLNGKAQVFADLSAQEIQAVHDFLMSRPELELQPTRMQVLGKNSVFLIEMLLPKKKDVLEFLDKGTKVPVREAHVVIFFSAQEHPNVTEFAVGPLPQPMYMRELSPRPAKHRSWASRPMTKAERSLLYHKIKEATTPLQKFFLDTTGFSLEDCNGHCLTFTHVAPHSVESRHRATWFLLQRIVKDRLLQPTGLEILVNHGSTDVQDWSIEQVWYNDKLYNSPEELAQKYADGEVDTVVLKDPLPENTEQSQIFNKPAGEIPLPPSKTGHHVEQVSVPSYRLEGNTVIYKGWSFSFQLRPSSGLQILNAHFKNEPLAYEISVQAAMAVHRENTPAGELTKTMDLGWSMGSVTHELAPGVNCPETATFLDAVHYYDTDGPVHYPQALCIFEIPTGVPVRPIFNTDFPGKVNFFSDVTGHKLVLRATSALYNFDYIWDFIFYTNGMISAKMHATGYTYTTIYTPEGLGETRLITHQLGNSHTHLVHYRVDLDVAGTNNSFHTLHTRQKNTTNPGSLRPHLVQDTMEKTQYSQERQATFPFGQTLPPFLLFSSPQTDIWGHRRSYRLQIYSTSKQKLTPASQEDLAFSWARYSLAVTKYWESERCSTSIYNQNHPWDPPVVFEEFLQNDESIEDQDLVAWVTVGFSHGPHSEIVPSVASARNFVGFLLRPFNFFYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3HBP1</accession>
    <name>G3HBP1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor NUBP2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nucleotide-binding protein 2</fullName>
            <shortName evidence="12">NBP 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Nubp2</name>
        <name evidence="12" type="synonym">NUBP2</name>
        <name evidence="13" type="ORF">I79_007945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. Interacts with NUBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">Cytoskeleton</location>
            <location evidence="12">Microtubule organizing center</location>
            <location evidence="12">Centrosome</location>
        </subcellularLocation>
        <text evidence="12">Enriched at the centrosomes during mitosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000273">
        <property type="protein sequence ID" value="EGW04430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640380.1">
        <property type="nucleotide sequence ID" value="XM_007642190.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280811.1">
        <property type="nucleotide sequence ID" value="XM_027425010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HBP1"/>
    <dbReference type="STRING" id="10029.G3HBP1"/>
    <dbReference type="PaxDb" id="10029-XP_007640379.1"/>
    <dbReference type="GeneID" id="100752903"/>
    <dbReference type="KEGG" id="cge:100752903"/>
    <dbReference type="CTD" id="10101"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HBP1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000796">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW04430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027280811.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29096" checksum="FC3B204AB2C5CA16" modified="2011-11-16" version="1">MEAVAEPGNLAGVRNIILVLSGKGGVGKSTISTELALALRHQGKKVGILDVDLCGPSIPRMLRAQGKAVHQCDQGWVPVFVDQEKTISLMSVGFLLENPDEAVVWRGPKKHALIKQFVSDVAWGELDYLVVDTPPGTSDEHMATVEALRPYRPLGALVVTTPQAVSVGDVRRELTFCRKTGLQVIGVIENMSGFACPHCAECTNVFSRGGGEELAQLAGVPFLGSVPLDPQLTRSLEEGCDFIQEFPKSTAYSALISIAQKVLHRMPALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3HC64</accession>
    <name>G3HC64_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 21">FAD synthase</fullName>
            <ecNumber evidence="7 21">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17 21">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 21">FMN adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Flavin adenine dinucleotide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 27 28" type="primary">Flad1</name>
        <name evidence="23" type="ORF">I79_008014</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26 27 28" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26 27 28">17A/GY</strain>
            <tissue evidence="26 27 28">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 21">Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 21">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="7 21"/>
    <dbReference type="EMBL" id="JH000275">
        <property type="protein sequence ID" value="EGV98100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640443.1">
        <property type="nucleotide sequence ID" value="XM_007642253.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640444.1">
        <property type="nucleotide sequence ID" value="XM_007642254.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249049.1">
        <property type="nucleotide sequence ID" value="XM_027393248.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249050.1">
        <property type="nucleotide sequence ID" value="XM_027393249.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307756.1">
        <property type="nucleotide sequence ID" value="XM_035451865.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311193.1">
        <property type="nucleotide sequence ID" value="XM_035455302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HC64"/>
    <dbReference type="STRING" id="10029.G3HC64"/>
    <dbReference type="PaxDb" id="10029-XP_007612619.1"/>
    <dbReference type="GeneID" id="100774575"/>
    <dbReference type="KEGG" id="cge:100774575"/>
    <dbReference type="CTD" id="80308"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HC64"/>
    <dbReference type="OMA" id="NSHFLCK"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006771">
        <property type="term" value="P:riboflavin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000113">
        <property type="entry name" value="FAD synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000007">
        <property type="entry name" value="FAD synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012183">
        <property type="entry name" value="FAD_synth_MoaB/Mog-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036620">
        <property type="entry name" value="MPTbdFAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 21" id="KW-0274">FAD</keyword>
    <keyword evidence="10 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 21" id="KW-0288">FMN</keyword>
    <keyword evidence="14 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="22">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR036620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV98100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027249049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027249050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_035307756.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="54362" checksum="FCE8BB077A1023C2" modified="2011-11-16" version="1">MASRASELPPGRSVTAGIIIVGDEILKGHTQDTNTYFLCRTLRSLGVQVCRVSVVPDEVATIAAEVTSFSSRFTHVLTAGGIGPTHDDVTFEAVAQAFGEELKPHPELQAAIKTLGGVGWEKLSLVPSSASLHYGTDPRTGQPFTFPLVSVRNVYLFPGIPELLRRAMEGLKGLFQNTAVQFHVKELYVAAPEGSIASILTEAQAHFGRRLSLGSYPDWGSNYYQVKLILDSEEKEPLEECLAYLTARLPQGSLVPYLPNAVEQAGEAVYKLAQSGSCLGKKVASALQTIETALDQYHLSKLCVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRSISPFPELEQFLQDTIKRYNLQVLEAEGNMKQALGELQEKHPQLEAVLMGTRRTDPYSCSLSHFSPTDPGWPSFMRINPLLDWTYRNIWDFLRQLFVPYCILYDRGYTSLGSRENTMQNPALKCLSPGGHPVYRPAYLLENEDEERNSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3HKP6</accession>
    <name>G3HKP6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Pfkfb4</name>
        <name evidence="12" type="ORF">I79_011275</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000468">
        <property type="protein sequence ID" value="EGV92135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504287.1">
        <property type="nucleotide sequence ID" value="XM_003504239.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270420.1">
        <property type="nucleotide sequence ID" value="XM_027414619.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HKP6"/>
    <dbReference type="STRING" id="10029.G3HKP6"/>
    <dbReference type="GlyGen" id="G3HKP6">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007632955.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028527.1">
        <property type="protein sequence ID" value="ENSCGRP00001024281.1"/>
        <property type="gene ID" value="ENSCGRG00001022250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761571"/>
    <dbReference type="KEGG" id="cge:100761571"/>
    <dbReference type="CTD" id="5210"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182835"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF14">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="256"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV92135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027270420.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="54071" checksum="E5D1448A7A06F0D9" modified="2011-11-16" version="1">MASPRELTQNPLKKIWMPYSNGRPALHASQRGVCMTNCPALIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALAALCDVRKFLSEEGGHVAVFDATNTTRERRAMIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYETLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRTVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKHLAQFISDQNIKDLKVWTSQMKRTIQTAEALSVPYEQWKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEELPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPSEEALVTVPAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G3HL53</accession>
    <name>G3HL53_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">LOC100755277</name>
        <name evidence="15" type="ORF">I79_011438</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000477">
        <property type="protein sequence ID" value="EGV94012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504412.1">
        <property type="nucleotide sequence ID" value="XM_003504364.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245528.1">
        <property type="nucleotide sequence ID" value="XM_027389727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HL53"/>
    <dbReference type="STRING" id="10029.G3HL53"/>
    <dbReference type="PaxDb" id="10029-XP_007624998.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002425.1">
        <property type="protein sequence ID" value="ENSCGRP00001001966.1"/>
        <property type="gene ID" value="ENSCGRG00001001972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755277"/>
    <dbReference type="KEGG" id="cge:100755277"/>
    <dbReference type="eggNOG" id="ENOG502SIA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153255"/>
    <dbReference type="OMA" id="GLFCLFY"/>
    <dbReference type="OrthoDB" id="6147321at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15420">
        <property type="entry name" value="7tmA_OR2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV94012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027245528.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35159" checksum="FD87A06AFF9493ED" modified="2011-11-16" version="1">MRGNQTWITEVILLGFQADLTVECFLFGLFSLFYSFTLLGNGVILGIICLDRRLHTPMYFFLSHLAIVDMSYASNNVPKMLANLMTKRRTISFIPCIMQTFLYLTFAHIECLILVVMSYDRFVAICHPLHYTVIMSWRVCTTLAAASWIFSFLLALVHIILILRLPFCGPNEINHFFCEILSVLQLACADTTLNQVVIFAACVFILVGPLCLVLVSYTRILVAILRIQSGEGRKKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQHPEEQQKILSLFYSLFNPMLNPLIYSLRNAEVKGALRRALWKERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G3HLS7</accession>
    <name>G3HLS7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delayed-rectifier potassium channel regulatory subunit KCNS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Delayed-rectifier K(+) channel alpha subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Delayed-rectifier potassium channel subunit Kv9.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Potassium voltage-gated channel modifier subfamily S member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Kcns1</name>
        <name evidence="22" type="ORF">I79_011671</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EGV98296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504636.1">
        <property type="nucleotide sequence ID" value="XM_003504588.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279272.1">
        <property type="nucleotide sequence ID" value="XM_027423471.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HLS7"/>
    <dbReference type="STRING" id="10029.G3HLS7"/>
    <dbReference type="PaxDb" id="10029-XP_007617844.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008015.1">
        <property type="protein sequence ID" value="ENSCGRP00001005236.1"/>
        <property type="gene ID" value="ENSCGRG00001006841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762339"/>
    <dbReference type="KEGG" id="cge:100762339"/>
    <dbReference type="CTD" id="3787"/>
    <dbReference type="eggNOG" id="KOG3713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160096"/>
    <dbReference type="OMA" id="CSGRYHE"/>
    <dbReference type="OrthoDB" id="296522at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Potassium voltage-gated channel subfamily S member 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
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        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
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    <dbReference type="InterPro" id="IPR028325">
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    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR11537:SF61">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
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        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
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        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="21">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00038289"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV98296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027279272.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="54641" checksum="C85FD706DBDB94DF" modified="2011-11-16" version="1">MVSESPGPGSRVPWRPRDEALRVNVGGVRRLLSAHALARFPGTRLGRLQAAASEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERRVTRPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSADDARDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGGRRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEEENEGFDTIPACWWWGTVSMTTVGYGDVVPETVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRSSGQRAFEDLLSSVDGVSEVSLETSQETSQEGRSTDLETQAPSETAKPQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3HQR7</accession>
    <name>G3HQR7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">LOC103161510</name>
        <name evidence="7" type="ORF">I79_013173</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit. Binds IPO9 with high affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000617">
        <property type="protein sequence ID" value="EGW09096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306837.1">
        <property type="nucleotide sequence ID" value="XM_035450946.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313914.1">
        <property type="nucleotide sequence ID" value="XM_035458023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HQR7"/>
    <dbReference type="STRING" id="10029.G3HQR7"/>
    <dbReference type="PaxDb" id="10029-XP_007611098.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002281.1">
        <property type="protein sequence ID" value="ENSCGRP00001001879.1"/>
        <property type="gene ID" value="ENSCGRG00001001839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103161510"/>
    <dbReference type="KEGG" id="cge:103161510"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PNELCKR"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="6">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGW09096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035306837.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20349" checksum="E64100F0384242F9" modified="2011-11-16" version="1">MKASGTLGEYKVVGRCLPIPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSREIVYCGQVFEKSPLRVKNFGIRLRCDSRSGTHNMYRESRDLTTAGAVTQCYGDMGAWHRARAHSIHIMKVGEIAASKCQRPAVKQFHDSKIKFPLPHRVLRGQHKPRFTTKRPNTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3HVE7</accession>
    <name>G3HVE7_CRIGR</name>
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        <submittedName>
            <fullName evidence="18">Neuropeptide Y receptor Y6</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17 21">Neuropeptide Y receptor type 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">LOC100773047</name>
        <name evidence="17" type="ORF">I79_014934</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000771">
        <property type="protein sequence ID" value="EGW11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003507337.1">
        <property type="nucleotide sequence ID" value="XM_003507289.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256629.1">
        <property type="nucleotide sequence ID" value="XM_027400828.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HVE7"/>
    <dbReference type="STRING" id="10029.G3HVE7"/>
    <dbReference type="PaxDb" id="10029-XP_007615763.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006960.1">
        <property type="protein sequence ID" value="ENSCGRP00001004623.1"/>
        <property type="gene ID" value="ENSCGRG00001005907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773047"/>
    <dbReference type="KEGG" id="cge:100773047"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163511"/>
    <dbReference type="OMA" id="ISHAYWG"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001601">
        <property type="term" value="F:peptide YY receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000062">
        <property type="entry name" value="Neuropeptide Y receptor type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000986">
        <property type="entry name" value="NeuroY6_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF16">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR TYPE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01017">
        <property type="entry name" value="NRPEPTIDEY6R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 14 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="52"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027256629.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42860" checksum="89D05219F34C2E51" modified="2011-11-16" version="1">MEVPLHQPGPNKTSAKSNNSSFFYFESCQPPFLAILLLLIVYTVVLIMGIFGNLSLIIIIFKKQREAQNVTNILIANLSLSDILVCVMCIPFTVIYTLMDHWIFGNTMCKLTSYVQSVSISVSIFSLVLIAIERYQLIVNPRGWKPRVSHAYWGIILIWLISLSLSIPLFLSYHLTNEPFHNLSLPNDIYTHRVACVEIWPSKLNQLLFSTSLFMLQYFVPLGFILICYLRIVICLRKRTKKVDRRKENESRLNENKRINVMLISIVVTFGACWLPLNIFNVIFDWYHEMLMSCHHDLVFVVCHLVAMVSTCINPLFYGFLNKNFQKDLMTLIHHCWCMAPQERYENIALSTMHTDESKGSLRLAHITTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3HWL5</accession>
    <name>G3HWL5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Vps28</name>
        <name evidence="10" type="ORF">I79_015347</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS37B, VPS37C, MVB12A and MVB12B. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with VPS36; the interaction mediates the association with the ESCRT-II complex. Interacts with SNF8 and VPS25. Interacts with CEP55.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000832">
        <property type="protein sequence ID" value="EGV92700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003507704.1">
        <property type="nucleotide sequence ID" value="XM_003507656.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260088.1">
        <property type="nucleotide sequence ID" value="XM_027404287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HWL5"/>
    <dbReference type="SMR" id="G3HWL5"/>
    <dbReference type="STRING" id="10029.G3HWL5"/>
    <dbReference type="GlyGen" id="G3HWL5">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007610745.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019588.1">
        <property type="protein sequence ID" value="ENSCGRP00001015347.1"/>
        <property type="gene ID" value="ENSCGRG00001015974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761380"/>
    <dbReference type="KEGG" id="cge:100761380"/>
    <dbReference type="CTD" id="51160"/>
    <dbReference type="eggNOG" id="KOG3284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000397">
        <property type="term" value="P:positive regulation of ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 6 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="8">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV92700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027260088.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25480" checksum="0675A554C010CE9D" modified="2011-11-16" version="1">MFHGIPATPGIGAPGNKPELYEEVKLYKNAREREKYDNMAELFAVVKTMQALEKAYIKDCVTPNEYTAACSRLLVQYKAAFRQVQGSEISSIDEFCRKFRLDCPLAMERIKEDRPITIKDDKGNLNRCIADVVSLFITIMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMSASDELDDSQVRQMLFDLESAYNAFNRFLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G3I025</accession>
    <name>G3I025_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">Cldn9</name>
        <name evidence="10" type="ORF">H671_7g18555</name>
        <name evidence="9" type="ORF">I79_016728</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
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            <location evidence="8">Cell junction</location>
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        <subcellularLocation>
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        <text evidence="1 8">Belongs to the claudin family.</text>
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    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20">17A/GY</strain>
        </source>
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    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
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    <dbReference type="STRING" id="10029.G3I3T5"/>
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        <property type="gene ID" value="ENSCGRG00001010896.1"/>
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    <dbReference type="GeneID" id="100765367"/>
    <dbReference type="KEGG" id="cge:100765367"/>
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    <dbReference type="eggNOG" id="KOG3656">
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    <dbReference type="GeneTree" id="ENSGT00940000156819"/>
    <dbReference type="OMA" id="AIQCIYA"/>
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    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR000586">
        <property type="entry name" value="Somatstn_rcpt"/>
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    <dbReference type="InterPro" id="IPR001512">
        <property type="entry name" value="Somatstn_rcpt_4"/>
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    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF35">
        <property type="entry name" value="SOMATOSTATIN RECEPTOR TYPE 4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00246">
        <property type="entry name" value="SOMATOSTATNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00590">
        <property type="entry name" value="SOMATOSTTN4R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 13 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="49"/>
            <end position="69"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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            <end position="104"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="291"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="60"/>
            <end position="307"/>
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            <begin position="1"/>
            <end position="36"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW02597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035301967.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="41974" checksum="EDA27572A68C9576" modified="2011-11-16" version="1">MNVPSTLPPGGEDITWTPGTNTSSSPDDEEDAVRSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGPGCICPPLPCQQEPMPVEPGCKQVPFTKTTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3I501</accession>
    <name>G3I501_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H1.0</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histone H1'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Histone H1(0)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">LOC100752547</name>
        <name evidence="14" type="ORF">I79_018542</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001276">
        <property type="protein sequence ID" value="EGV94326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510320.1">
        <property type="nucleotide sequence ID" value="XM_003510272.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259780.1">
        <property type="nucleotide sequence ID" value="XM_027403979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I501"/>
    <dbReference type="STRING" id="10029.G3I501"/>
    <dbReference type="GlyGen" id="G3I501">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_003510320.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012608.1">
        <property type="protein sequence ID" value="ENSCGRP00001008479.1"/>
        <property type="gene ID" value="ENSCGRG00001010756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752547"/>
    <dbReference type="KEGG" id="cge:100752547"/>
    <dbReference type="eggNOG" id="KOG4012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF182">
        <property type="entry name" value="HISTONE H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0164">Citrullination</keyword>
    <keyword evidence="5 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="13">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="105"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV94326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027259780.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="20901" checksum="5960D9EF1750C009" modified="2011-11-16" version="1">MTENSTSTPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKGDEPKRSVAFKKTKKEVKKVATPKKAAKPKKAAAKAPSKKPKATPVKKAKKKPAATPKKAKKPKIVKAKPVKTTKPKKAKPVKPKAKSSAKRASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3I6I0</accession>
    <name>G3I6I0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine/tyrosine-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive tyrosine-protein phosphatase STYX</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoserine/threonine/tyrosine interaction protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Styx</name>
        <name evidence="9" type="ORF">I79_019104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH001368">
        <property type="protein sequence ID" value="EGW01226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510775.1">
        <property type="nucleotide sequence ID" value="XM_003510727.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245090.1">
        <property type="nucleotide sequence ID" value="XM_027389289.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I6I0"/>
    <dbReference type="STRING" id="10029.G3I6I0"/>
    <dbReference type="PaxDb" id="10029-XP_007628473.1"/>
    <dbReference type="GeneID" id="100762262"/>
    <dbReference type="KEGG" id="cge:100762262"/>
    <dbReference type="CTD" id="6815"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I6I0"/>
    <dbReference type="OMA" id="EWRYEMR"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14522">
        <property type="entry name" value="DSP_STYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000036">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00079004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW01226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027245090.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25536" checksum="08448A3C0C53AD8E" modified="2011-11-16" version="1">MEDVKLEFPSLPQCKDYAEEWTYPMRREMQEVLPGLFLGPYSSAMKSKLPILQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQNGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKLTIQMMSPLQIERSLTVHSGTTGSLKRTHEEEDDFGNMQVATAQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3I6Z4</accession>
    <name>G3I6Z4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylinositol polyphosphate 5-phosphatase type IV</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
            <ecNumber evidence="3">3.1.3.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">72 kDa inositol polyphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Inositol polyphosphate-5-phosphatase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Phosphatidylinositol 4,5-bisphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Inpp5e</name>
        <name evidence="20" type="ORF">I79_019274</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25528"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="EC" id="3.1.3.86"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32955"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:32956"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22765"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts (when prenylated) with PDE6D; this is important for normal location in cilia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EC" id="3.1.3.86" evidence="3"/>
    <dbReference type="EMBL" id="JH001398">
        <property type="protein sequence ID" value="EGW12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510903.1">
        <property type="nucleotide sequence ID" value="XM_003510855.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278770.1">
        <property type="nucleotide sequence ID" value="XM_027422969.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I6Z4"/>
    <dbReference type="STRING" id="10029.G3I6Z4"/>
    <dbReference type="GlyGen" id="G3I6Z4">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007637242.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028285.1">
        <property type="protein sequence ID" value="ENSCGRP00001024039.1"/>
        <property type="gene ID" value="ENSCGRG00001022064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759837"/>
    <dbReference type="KEGG" id="cge:100759837"/>
    <dbReference type="CTD" id="56623"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158199"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903565">
        <property type="term" value="P:negative regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902140">
        <property type="term" value="P:response to inositol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09095">
        <property type="entry name" value="INPP5c_INPP5E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000039">
        <property type="entry name" value="72 kDa inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042478">
        <property type="entry name" value="INPP5E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46625">
        <property type="entry name" value="72 KDA INOSITOL POLYPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46625:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL POLYPHOSPHATE 5-PHOSPHATASE TYPE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="19">
        <location>
            <begin position="292"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGW12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027278770.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="70886" checksum="D7494263471F596E" modified="2011-11-16" version="1">MPSKSACLRHTEAPGQLEGRMLQGQLPNTDKNLTPTPGSLPATEPQGSETNPMPPFSIPAKPSNQNPQLPMRPKLERTLSLDDKGWRRRRFQGSQEDLTVQNGASPCRGSMQDSVTQFPACSRPLPCLSTSLQEIPKTRRATGSEGGSPSVWSDCLPGMISTSLDLLHRETTPGGGSPKLASLHAAHTPPAMDLNIASSSLRTANKVDPEHADYKLRMQTRLVRAHSSLGPSRPRSPLAGDDHSILSARSSFSLLAPIRTKDIRSRSYLEGSLMASGALLGADELVRYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGVQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQDPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKELQKQTMKNQSSSAVCTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3I7G2</accession>
    <name>G3I7G2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Hexosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">B3gnt6</name>
        <name evidence="14" type="ORF">I79_019451</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JH001428">
        <property type="protein sequence ID" value="EGW04280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297525.1">
        <property type="nucleotide sequence ID" value="XM_035441634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I7G2"/>
    <dbReference type="STRING" id="10029.G3I7G2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000849.1">
        <property type="protein sequence ID" value="ENSCGRP00001000825.1"/>
        <property type="gene ID" value="ENSCGRG00001000647.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768656"/>
    <dbReference type="KEGG" id="cge:100768656"/>
    <dbReference type="CTD" id="192134"/>
    <dbReference type="GeneTree" id="ENSGT00940000163174"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008499">
        <property type="term" value="F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030311">
        <property type="term" value="P:poly-N-acetyllactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000009">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF382">
        <property type="entry name" value="ACETYLGALACTOSAMINYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW04280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035297525.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43712" checksum="E5289E40434CD46B" modified="2011-11-16" version="1">MARLSCRSKNPKTLALLLVGVTFVGLHQWVLQMPTQEKGEGTTAAPRSSAAAVQPSPHLPVPRCVANASVNLTAGFEELPVRIQDFLRYRHCRSFPQLWDAPHKCAGHRGVFLLLAVKSSPAHYERRELIRRTWGQERSYSGRQVRRLFLLGTSPPEEAEREPQLADLLDLEAREHGDVLQWDFKDTFLNLSLKHLHLLDWTAERCPGASFLLSCDDDVFVHTANVLHFLEEQSPERHLFTGQLMDGSVPIRDSWSKYFVPPQLFPGKAYPVYCSGGGFLLSSRTARDLRSAAFHVPLFPIDDAYMGMCLQQAGLAPSGHEGIRPFGVRLPGAQRSSFDPCMYRELLLVHRFAPYEMLLMWKALHNPELHCSHRYRVGSPEARKLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3I9Q8</accession>
    <name>G3I9Q8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spindlin family, member 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2 3 8">Spindlin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">LOC100767892</name>
        <name evidence="3" type="ORF">H671_xg19856</name>
        <name evidence="2" type="ORF">I79_020314</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPIN/STSY family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001638">
        <property type="protein sequence ID" value="EGW09508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE682983">
        <property type="protein sequence ID" value="ERE65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027239846.1">
        <property type="nucleotide sequence ID" value="XM_027384045.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287705.1">
        <property type="nucleotide sequence ID" value="XM_027431904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I9Q8"/>
    <dbReference type="STRING" id="10029.G3I9Q8"/>
    <dbReference type="PaxDb" id="10029-XP_007621737.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002672.1">
        <property type="protein sequence ID" value="ENSCGRP00001002113.1"/>
        <property type="gene ID" value="ENSCGRG00001002178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767892"/>
    <dbReference type="KEGG" id="cge:100767892"/>
    <dbReference type="eggNOG" id="ENOG502QRYD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182925"/>
    <dbReference type="OMA" id="HGKKDEW"/>
    <dbReference type="OrthoDB" id="9944558at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.70:FF:000001">
        <property type="entry name" value="Spindlin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.70">
        <property type="entry name" value="Spindlin/Ssty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003671">
        <property type="entry name" value="SPIN/Ssty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042567">
        <property type="entry name" value="SPIN/Ssty_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10405">
        <property type="entry name" value="SPINDLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02513">
        <property type="entry name" value="Spin-Ssty"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW09508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ERE65895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027287705.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28510" checksum="46919955A4700439" modified="2011-11-16" version="1">MSPPTVPPTGVDGVSAYLMKKRHTHKKQRRKPTFLTHRNIVGCRIQHGWKEGNEPVEQWKGTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEVLPERVPSPRVDSRLADSLVGKAVGHVFEGEHGKKDEWKGMVLARAPIMDTWFYITYEKDPVLYMYTLLDDYKDGDLRIIPDSNYYFPTAEQEPGEVLDSLVGKQVEHAKDDGSKRTGIFIHQVVAKPSVYFIKFDDDIHIYVYGLVKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3IDB9</accession>
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            <fullName evidence="3 8">Electron transfer flavoprotein subunit beta</fullName>
            <shortName evidence="8">Beta-ETF</shortName>
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    </protein>
    <gene>
        <name evidence="12 15" type="primary">Etfb</name>
        <name evidence="11" type="ORF">I79_021695</name>
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    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.</text>
    </comment>
    <comment type="function">
        <text evidence="8">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002037">
        <property type="protein sequence ID" value="EGW04637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512891.1">
        <property type="nucleotide sequence ID" value="XM_003512843.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276660.1">
        <property type="nucleotide sequence ID" value="XM_027420859.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IDB9"/>
    <dbReference type="STRING" id="10029.G3IDB9"/>
    <dbReference type="PaxDb" id="10029-XP_007623455.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028502.1">
        <property type="protein sequence ID" value="ENSCGRP00001024256.1"/>
        <property type="gene ID" value="ENSCGRG00001022229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753078"/>
    <dbReference type="KEGG" id="cge:100753078"/>
    <dbReference type="CTD" id="2109"/>
    <dbReference type="eggNOG" id="KOG3180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009936"/>
    <dbReference type="OMA" id="EINQPRI"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="10">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000090-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW04637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027276660.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="27705" checksum="3108B595648E93D2" modified="2011-11-16" version="1">MAELRALVAVKRVIDFAVKIRVKPDKSGVVTDGVKHSMNPFCEIAVEEAVRLKEKKLVKEVIAVSCGPSQCQETIRTALAMGADRGIHVEVPAAQAESLGPLQVARVLAKLAEKEKVDLVFLGKQAIDDDCNQTGQMTAGLLDWPQGTFASQLTLEGDKIKVEREIDGGLETLRLKLPSVVTADLRLNEPRYATLPNIMKAKKKKIEVIKPGDLGVDLTSKVSVISVEEPPQRLAGVKVETTEDLVAKLKEVGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3IEX5</accession>
    <name>G3IEX5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantothenate--cysteine ligase</fullName>
            <ecNumber evidence="5">6.3.2.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphopantothenoylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Ppcs</name>
        <name evidence="9" type="ORF">I79_022280</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantothenate + L-cysteine + ATP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25156"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.51"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:25157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + L-cysteine + CTP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + CMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:19398"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.51" evidence="5"/>
    <dbReference type="EMBL" id="JH002285">
        <property type="protein sequence ID" value="EGW10661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513379.1">
        <property type="nucleotide sequence ID" value="XM_003513331.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254915.1">
        <property type="nucleotide sequence ID" value="XM_027399114.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IEX5"/>
    <dbReference type="SMR" id="G3IEX5"/>
    <dbReference type="STRING" id="10029.G3IEX5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016539.1">
        <property type="protein sequence ID" value="ENSCGRP00001012306.1"/>
        <property type="gene ID" value="ENSCGRG00001013754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768962"/>
    <dbReference type="KEGG" id="cge:100768962"/>
    <dbReference type="CTD" id="79717"/>
    <dbReference type="GeneTree" id="ENSGT00950000182834"/>
    <dbReference type="OMA" id="LERYQHH"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003015">
        <property type="term" value="P:heart process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10300:FF:000002">
        <property type="entry name" value="Phosphopantothenate--cysteine ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="8">
        <location>
            <begin position="166"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00052332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW10661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027254915.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="33823" checksum="612256BB458FFB65" modified="2011-11-16" version="1">MAEMDLAADLPPPEGAARWADVMARFAASLGAQGRRVVLVTSGGTKVPLEARAVRFLDNFSSGRRGAKSVEVFLAAGYGVLFLYRARSAFPYAHRFPPQAWLSALRPSGPAQSGKLRLEAEENALPGFAAALQSYQEAAAAGTFLAIEFTTLADYLHLLQAAAQALSPLGSSAMFYLAAAVSDFYIPVSEMPEHKIHSSGGPLQITMKMVPKMLSPLVKDWAPKAFIVSFKLETDPSIIINRARNALEVYQHQVVVANILESIQSFVIIVTKDSETKLLLSEDEIAKGMVIEEKIVEDLRSRHTAFICDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3IHE5</accession>
    <name>G3IHE5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding nuclear protein Ran</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">LOC100771164</name>
        <name evidence="11" type="ORF">H671_2g5922</name>
        <name evidence="10" type="ORF">I79_023234</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002759">
        <property type="protein sequence ID" value="EGW13528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE667920">
        <property type="protein sequence ID" value="ERE84500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514142.1">
        <property type="nucleotide sequence ID" value="XM_003514094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259422.1">
        <property type="nucleotide sequence ID" value="XM_027403621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IHE5"/>
    <dbReference type="SMR" id="G3IHE5"/>
    <dbReference type="STRING" id="10029.G3IHE5"/>
    <dbReference type="PaxDb" id="10029-XP_007618142.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005606.1">
        <property type="protein sequence ID" value="ENSCGRP00001003820.1"/>
        <property type="gene ID" value="ENSCGRG00001004727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771164"/>
    <dbReference type="KEGG" id="cge:100771164"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153786"/>
    <dbReference type="OMA" id="NACGVEN"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF3">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGW13528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ERE84500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027259422.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24486" checksum="668F05AF6E236E88" modified="2011-11-16" version="1">MAAQGEPPVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLLFHTSRGPIKFNVWDTAGQEKFGGLRDGYYIQAQSAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDVKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLSRRLTGDPNLEFVAMPALAPPEVIMDPVLAMKYERDLEVAQATALPDEEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3IIU3</accession>
    <name>G3IIU3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Atg101</name>
        <name evidence="5" type="ORF">I79_023771</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH003114">
        <property type="protein sequence ID" value="EGW05558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514575.1">
        <property type="nucleotide sequence ID" value="XM_003514527.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252434.1">
        <property type="nucleotide sequence ID" value="XM_027396633.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IIU3"/>
    <dbReference type="STRING" id="10029.G3IIU3"/>
    <dbReference type="PaxDb" id="10029-XP_007614480.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016864.1">
        <property type="protein sequence ID" value="ENSCGRP00001012629.1"/>
        <property type="gene ID" value="ENSCGRG00001014001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763923"/>
    <dbReference type="KEGG" id="cge:100763923"/>
    <dbReference type="CTD" id="60673"/>
    <dbReference type="eggNOG" id="KOG4493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016511"/>
    <dbReference type="OMA" id="TMNCRSE"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGW05558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027252434.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24974" checksum="00E2855EF3FC285F" modified="2011-11-16" version="1">MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGIQDVDCDFIDFTYVRVSSDELDRALRKVVGEFKDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMSRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITDALGTSVTTTMRRLIKDTLAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="203" xmlns="https://uniprot.org/uniprot">
    <accession>O09185</accession>
    <accession>P97258</accession>
    <accession>P97788</accession>
    <accession>Q64397</accession>
    <name>P53_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Cellular tumor antigen p53</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Tumor suppressor p53</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TP53</name>
        <name type="synonym">P53</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Nucleic Acids Res." volume="25" first="992" last="994">
            <title>The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair.</title>
            <authorList>
                <person name="Chaung W."/>
                <person name="Mi L.J."/>
                <person name="Boorstein R.J."/>
            </authorList>
            <dbReference type="PubMed" id="9023109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>VARIANTS GLN-133 AND TRP-135</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Gene" volume="184" first="177" last="183">
            <title>Cloning and characterization of Chinese hamster p53 cDNA.</title>
            <authorList>
                <person name="Lee H."/>
                <person name="Larner J.M."/>
                <person name="Hamlin J.L."/>
            </authorList>
            <dbReference type="PubMed" id="9031625"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00592-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Liver</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="1996-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Shimizu T."/>
                <person name="Nikaido O."/>
                <person name="Suzuki F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Embryonic fibroblast</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 3 4">Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest (By similarity). Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3. Interacts (via C-terminus) with POU4F2 (via C-terminus). Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53. Interacts with AFG1L; mediates mitochondrial translocation of TP53. Interacts with UBD (By similarity). Interacts with TAF6 (By similarity). Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity). Interacts with NUPR1; interaction is stress-dependent. Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent (By similarity). Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 (By similarity). Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity (By similarity). When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin (By similarity). Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 (By similarity). Interacts (via N-terminus) with E3 ubiquitin-protein ligase MUL1; the interaction results in ubiquitination of cytoplasmic TP53 at Lys-24 and subsequent proteasomal degradation (By similarity). Interacts with S100A4; this interaction promotes TP53 degradatio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <text evidence="3">Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity). Competitive inhibition of TP53 interaction with HSPA9/MOT-2 by UBXN2A results in increased protein abundance and subsequent translocation of TP53 to the nucleus (By similarity).</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The N-terminal and C-terminal disordered regions undergo liquid-liquid phase separation (LLPS) following homotetramerization and activation. Post-translational modifications, such as phosphorylation or lactylation affect the ability to undergo LLPS.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1 3">Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter (By similarity). Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-392 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-47, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-47 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity). Phosphorylation at Ser-392 regulates its ability to undergo liquid-liquid phase separation by increasing fluidity of TP53/p53 condensates.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-333 and dimethylated at Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2 3">Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (By similarity). Deubiquitinated by USP3, leading to stabilization (By similarity). Ubiquitinated by MSL2, promoting its cytoplasmic localization (By similarity). Also ubiquitinated by the SCF(FBXO22)-KDMA4A complex; leading to proteasomal degradation.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Acetylation of Lys-382 by EP300. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-381 increases stability. Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence. Acetylated at Lys-120 by KAT5, KAT6A and KAT8; regulating its ability to induce proapoptotic program.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Lactylation by AARS1 prevents ability to undergo liquid-liquid phase separation (LLPS), thereby inhibiting transcription factor activity.</text>
    </comment>
    <comment type="disease">
        <text>p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the p53 family.</text>
    </comment>
    <dbReference type="EMBL" id="Y08900">
        <property type="protein sequence ID" value="CAA70108.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="Y08901">
        <property type="protein sequence ID" value="CAA70109.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U50395">
        <property type="protein sequence ID" value="AAC53040.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="D86070">
        <property type="protein sequence ID" value="BAA13004.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC6176">
        <property type="entry name" value="JC6176"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001230905.1">
        <property type="nucleotide sequence ID" value="NM_001243976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O09185"/>
    <dbReference type="SMR" id="O09185"/>
    <dbReference type="PaxDb" id="10029-NP_001230905.1"/>
    <dbReference type="GeneID" id="100682525"/>
    <dbReference type="KEGG" id="cge:100682525"/>
    <dbReference type="CTD" id="7157"/>
    <dbReference type="eggNOG" id="ENOG502QVY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5915660at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0036310">
        <property type="term" value="F:ATP-dependent DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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    <dbReference type="GO" id="GO:0097371">
        <property type="term" value="F:MDM2/MDM4 family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051053">
        <property type="term" value="P:negative regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097252">
        <property type="term" value="P:oligodendrocyte apoptotic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08367">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000003">
        <property type="entry name" value="Cellular tumor antigen p53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.170.10:FF:000003">
        <property type="entry name" value="Cellular tumor antigen p53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057064">
        <property type="entry name" value="P53_central_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010991">
        <property type="entry name" value="p53_tetrameristn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013872">
        <property type="entry name" value="p53_transactivation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF6">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08563">
        <property type="entry name" value="P53_TAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07710">
        <property type="entry name" value="P53_tetramer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47719">
        <property type="entry name" value="p53 tetramerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00348">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0053">Apoptosis</keyword>
    <keyword id="KW-0090">Biological rhythms</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1210">Necrosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0043">Tumor suppressor</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000185698" description="Cellular tumor antigen p53">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="3">
        <location>
            <begin position="102"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with CCAR2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Transcription activation (acidic)">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with WWOX" evidence="1">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with HIPK1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for interaction with ZNF385A" evidence="1">
        <location>
            <begin position="100"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for interaction with FBXO42" evidence="1">
        <location>
            <begin position="113"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with AXIN1" evidence="1">
        <location>
            <begin position="116"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with E4F1" evidence="1">
        <location>
            <begin position="256"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="1">
        <location>
            <begin position="273"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with HIPK2" evidence="1">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Oligomerization">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with USP7" evidence="1">
        <location>
            <begin position="359"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Basic (repression of DNA-binding)">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear export signal" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="[KR]-[STA]-K motif">
        <location>
            <begin position="370"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by HIPK4" evidence="3">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM" evidence="3">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by CK1, VRK1 and VRK2" evidence="3">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CHEK2, CK1 and PLK3" evidence="3">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CDK5 and CDK7" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by MAPKAPK5" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lactoyllysine" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lactoyllysine" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by AURKB" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by AURKB" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by AURKB" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by AURKA, CDK1 and CDK2" evidence="3">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="2">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="modified residue" description="Omega-N-methylarginine" evidence="3">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="modified residue" description="Symmetric dimethylarginine" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; by SMYD2; alternate" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; by SETD7" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate" evidence="3">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="3">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; by KMT5A; alternate" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK2, CDK2 and NUAK1" evidence="3">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="3">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)" evidence="1">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In cell line V79-4." evidence="6">
        <original>L</original>
        <variation>Q</variation>
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In cell line V79-4." evidence="6">
        <original>C</original>
        <variation>W</variation>
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AAC53040." evidence="7" ref="2">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P02340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P04637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="P10361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="9023109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="393" mass="43378" checksum="2A7830E788311689" modified="1997-07-01" version="1">MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLSTLPSSDSIEELFLSENVTGWLEDSGGALQGVAAAAASTAEDPVTETPAPVASAPATPWPLSSSVPSYKTYQGDYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVNSTPPPGTRVRAMAIYKKLQYMTEVVRRCPHHERSSEGDSLAPPQHLIRVEGNLHAEYLDDKQTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRRTEEKNFQKKGEPCPELPPKSAKRALPTNTSSSPPPKKKTLDGEYFTLKIRGHERFKMFQELNEALELKDAQASKGSEDNGAHSSYLKSKKGQSASRLKKLMIKREGPDSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q002B5</accession>
    <name>DPH2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Diphthamide biosynthesis protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphtheria toxin resistance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPH2</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2010" name="PLoS ONE" volume="5" first="e15753" last="e15753">
            <title>A dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin A and diphtheria toxin.</title>
            <authorList>
                <person name="Roy V."/>
                <person name="Ghani K."/>
                <person name="Caruso M."/>
            </authorList>
            <dbReference type="PubMed" id="21203470"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0015753"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH DPH1</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:21203470). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 3">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase (By similarity). Interacts with DPH1 (PubMed:21203470).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DQ981502">
        <property type="protein sequence ID" value="ABI97860.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233722.1">
        <property type="nucleotide sequence ID" value="NM_001246793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q002B5"/>
    <dbReference type="SMR" id="Q002B5"/>
    <dbReference type="PaxDb" id="10029-NP_001233722.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00000012230">
        <property type="protein sequence ID" value="ENSCGRP00000012040"/>
        <property type="gene ID" value="ENSCGRG00000008764"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001002960">
        <property type="protein sequence ID" value="ENSCGRP00001002285"/>
        <property type="gene ID" value="ENSCGRG00001002429"/>
    </dbReference>
    <dbReference type="GeneID" id="100689365"/>
    <dbReference type="KEGG" id="cge:100689365"/>
    <dbReference type="CTD" id="1802"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000307888" description="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for function" evidence="3">
        <location>
            <begin position="398"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N-acetylmethionine" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="2">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="2">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9BQC3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="21203470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="489" mass="52072" checksum="C3107E5D7558E925" modified="2006-11-14" version="1">MESTFSSPAEAALQREAGVPGLFTPPEDLDRVYELERVTKFVCDLGCQRVALQFPDQLLGDAGAVAVRLEEVTGSKMFILGDTAYGSCCVDVLGAEQAGAEALVHFGPACLSPPASLLPITFVLGQRSVALELCAKAFEARNPDPTAPVVLLSEPACAHALEALATLLRPKYQDLLISSPALPLPVGSPSSQPEPLERFGRRFPLSPGRCLEEYGAFYVGGSQASSDPVLDPDLSRLLLGWTPGRPFISCCPDTGQTQDQGVQAGRLRARRLYLIERARDAHVVGLLAGTLGVAQHREALAHLRKLTEAAGKRSYVLALGRPTPAKLANFPEMDIFVLLACPLGALAPQPSGGFFRPILTPCELEAACNPAWPPPGLAPHLTHYAELLPGSPFYVPLPPPESELWDTPDVSLISGDLRPPPSWKSSSDTGCSALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVKEAVQGRRGIAIAYEDEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IDV8</accession>
    <name>A0A061IDV8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat domain 13</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3 7">Tetratricopeptide repeat protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">Ttc13</name>
        <name evidence="3" type="ORF">H671_3g8990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">17A/GY</strain>
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    <reference evidence="7" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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            <strain evidence="7">17A/GY</strain>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IHW5</accession>
    <name>A0A061IHW5_CRIGR</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>urea = cyanamide + H2O</text>
            <dbReference type="Rhea" id="RHEA:23056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16698"/>
            <dbReference type="EC" id="4.2.1.69"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="8"/>
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        <property type="protein sequence ID" value="ERE84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027398734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IHW5"/>
    <dbReference type="GeneID" id="100774844"/>
    <dbReference type="KEGG" id="cge:100774844"/>
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    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018820">
        <property type="term" value="F:cyanamide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015670">
        <property type="term" value="P:carbon dioxide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03119">
        <property type="entry name" value="alpha_CA_I_II_III_XIII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbonic anhydrase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF120">
        <property type="entry name" value="CARBONIC ANHYDRASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ERE84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027254535.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29040" checksum="E94B3022B0B2DAB7" modified="2014-09-03" version="1">MSHHWGYSGHNGPEHWHKDFPIANGERQSPVDIDTKTAQHDPALQPLSVCYDQAASKKILNNGHSFNVEFDDSQDCAVLKGGPLSGTYRLIQFHFHWGSSDGHGSEHTVNKTKYAAELHLVHWNTKYGDFGKAVQHPDGLAVLGIFLKIGPATKGLQKVLDALESIKTKGKSAAFTNFDPRSLLPGNLDYWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMSQFRKLSFNAEGEPEEHMVDNWRPAQPLKNRKIKASFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IJE3</accession>
    <name>A0A061IJE3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial ornithine transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 25 member 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25 26" type="primary">Slc25a15</name>
        <name evidence="21" type="ORF">H671_1g2831</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25 26">17A/GY</strain>
            <tissue evidence="25 26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle. Lysine and arginine are also transported by the antiport mechanism. In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-citrulline(in) + L-ornithine(out) + H(+)(in) = L-citrulline(out) + L-ornithine(in) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70787"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysine(out) + H(+)(in) = L-lysine(in) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70795"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-ornithine(in) + L-arginine(out) = L-ornithine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:34991"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-ornithine(out) + H(+)(in) = L-ornithine(in) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70791"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)</text>
            <dbReference type="Rhea" id="RHEA:70799"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE665472">
        <property type="protein sequence ID" value="ERE88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251066.1">
        <property type="nucleotide sequence ID" value="XM_027395265.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251067.1">
        <property type="nucleotide sequence ID" value="XM_027395266.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312338.1">
        <property type="nucleotide sequence ID" value="XM_035456447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IJE3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018559.1">
        <property type="protein sequence ID" value="ENSCGRP00001014322.1"/>
        <property type="gene ID" value="ENSCGRG00001015230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773024"/>
    <dbReference type="KEGG" id="cge:100773024"/>
    <dbReference type="CTD" id="10166"/>
    <dbReference type="GeneTree" id="ENSGT00730000110966"/>
    <dbReference type="OMA" id="PIDCFRQ"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000055">
        <property type="entry name" value="mitochondrial ornithine transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF22">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="104"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="207"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ERE88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027251066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027251067.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="32818" checksum="C24FC5F0DFA772ED" modified="2014-09-03" version="1">MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKMVGLDRQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMESSGKIAASQNTVWSVVKEIFRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGKSKDELGPVPLMLSGGFGGICLWLAVYPVDCIKSRIQVLSMTGKQTGLVRTFLSIVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IQU7</accession>
    <name>A0A061IQU7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative small subunit processome component 20 like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Small subunit processome component 20 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Utp20</name>
        <name evidence="5" type="ORF">H671_1g1908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE664301">
        <property type="protein sequence ID" value="ERE90077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248380.1">
        <property type="nucleotide sequence ID" value="XM_027392579.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100772924"/>
    <dbReference type="KEGG" id="cge:100772924"/>
    <dbReference type="CTD" id="27340"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1812"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2379"/>
            <end position="2763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2591"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2600"/>
            <end position="2614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ERE90077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027248380.1"/>
        </source>
    </evidence>
    <sequence length="2786" mass="318013" checksum="2FDFE4724BA3BF09" modified="2014-09-03" version="1">MKPKPLSHKTENTYRFLTFAERLGNVNIDIIHRIDRTASYDEEVETYFFEALLKWRELNLTEHFGKFYKEVIDKCQSFNQLVYHQNEIVQSLKTHLQIRNSFAYQPLLDLVVQLARDLQTDFYPHFEDFFLTVTSILETQDTELLEWAFTSLSYLYKYLWRLMVKDMSKIYSMYSTLLAHKKLHIRNFAAESFTFLMRKVSDKNALFNLMFLDLNEHPEKVEGVGQLLFEMCKGVRNMFHSCTGQALKLILQKLGPVTETETQLPWILVGETLKNMAKSTVVYIYKEHFGIFFDCLQESLLELHNKVTEKNCCENSEQMSRLLETFLILVKHGSGSKITRPSDICRVLSEALQTDNLSTSCRKTLLDVVSALLLAENVSLPETLIKEIIEKIFESKFERRLIFDFSEVMFTMKQFEQLFLPSFLCYIENCFLIGDSVVCNEALAILAKLILNKAAPPTAGSMAIEKYPLVFSQQTVGSYLQQRKTDSKRRKEQSTVLDHLLAIVQSPPNKDTTYLSRSWAALVVLPHIRPLEKEKVLGLLSCFIDSLFMAVDKGSFGKGSLFVLCQAVNTLLSLEESSELLHLVPVERVKSLVLTFPAEPSVLLLADLYYQRLALCGCKGPLSEKALMELFPKLQANISTGVSKIRLLTIRILNHFDIQLPASMEDDGLSERQSAFAILRQAELVPATVSDYREKLLHLRKLRHDVVQDAAPQGPLQEVPLRYLLGMLYVNFSALWDPVIELISSHAHGMENKQFWSVCYEHLEKAAAHAEKELQKDMREAEQSTGDGSWEQAQEGDVGALYQQQLALKTDCRERLDHTNFRFLLWRALAKFPERIEPRSRELSPLFLRFINNEYYPADLQVAPTQDLRRKGRGAVAEVMEEEPAVEADEELEEEALPTDEAPQKKKTRRAAAKQLIAHLQVFSKFSNPRALYLESKLYELYLQLLLHQDQAVQKITLDCIMTYKHPHILPYRENLQRLLDDRSFKEEIVHFSISEDNTVVKATHRADLFPILMRILYGRMKNKTGSKTQGKSASGTRMAIVLRFLSGTQPGEIQLFLDLLSEPVKHFKNGECHSAVIRAVEDLDLSKVLPVGRQHGILNSLEVVLKTISHLISEYLPKILQILLCMTATVSHILEQREKIQLRFINPLKNLRRLGIKMISDIFLDWESYQFRAEEIDAVFHGAVWPQICRLGSESQYSPTPLLKLISIWSRNARYFPLLAKQKPGHPECDILTNVFAVLSAKNLSDATAGIIMDIVDDLLNLPDFEPTETMLSLPVTDCVYAEVADNTEPITVGGRLILPHVPAILQYLSKTTVSAEKVKKKKNRAQVSKELGILSKISKFMKDREQSSLLITLLLPFLLRGNVAQDTELDILVTVQNLLQHCQDPTSFLKPLAKLFSVIKNKLSRQLLCTVFQSLSGFESELKYITDIVKLNAFDKRHLDDINFDVRFSAFQTITSNIKEMQTVDADYLVPVMHNCFYNMELGDMSLSDNASMCLTSIIKKLAALNVTEKEYKEIIHRTLLEKLRKGLKSQTESVQHDYTMILSCLIQTFPNQVEFKDLVQLTHSHDPEMDFFENMKHIQIHRRARALKKLAKQLLERQVVLSSKSLQNYIMPYAMTPIFDEKMLKHENIIIAATEVIGAICRHLSWPAYVYYLKHFIHVLQTGQINQKLGVSLLVMVLEAFHFDYKTLEEQMGSVQDEENTVEMAELLEHEAMELEHVDEEEKEPARKSLSDEKEPLKTPDSGSIAATEQECISKSVSFLPRNKEELERTIKTIQGAITGDILPRLHKCLASATKREEEHKLVKSKVVNEEEVVRVPLAFAMVKLMRSLPQEVMEANLPSVLLKVCVLLKNRAQEVRDIARSTLSKIIEDLGVRFLQYVLKELQTTLVRGYQVHVLTFTVYTLLQGLTNKLQVGDLDPCLQIMTEIFNHELFGALAEEKEVKQILSKVMEARRSKSYDSYEILGKFVGKDQVTKLILPLKEILQNTTSLKLARKVHETLRRIIAGLIVNPDMTAESLLLLSYGLVSENLPLLTEKEKKPAAPAPDARLPPQSCLLLPPTPVRGGPKAVVSKKTNMHIFIESGLRLLHLSLKTSKIKSSSEHVLEMLDPFVSLLINCLGARDVKVITGSLQCLIWVLRFPLPSIESKAGQLTKHLFLLLKNYARLGAARGQNFHLVVNCFKCVTIVVKKVKSYQITEKQLQVLLAYAEEDIYDTTRQATAFGLLKAILSRKLLVPEIDDIMRKVSKLAISAQNEPARVQCRQVFLKYILDYPLGEKLRPNLEFMLAQLNYEHETGRESTLEMIAYLFDTFPQGLLHDTCGMFFIPLCLMMVNDDSAMCKKMASMAIKSLLSKVNLEKRDWLFGLVTSWFEAKKRLNRQLAALTCGLFVESEGVDFERRLGTLLPVIEKEINPENFKDIIEEVEEKAADRLLFGFLTLISKLIKECNIIHFTKPSETLNKIWSHVHSHLRHPHNWVWLTAAQIFGLLFASCQPEELIQKWKNKKTKKKPTEPVAVRFLTSDLDQKMKSISLASCHQLHSKFLDESLGEQVVKNLLFIAKVLYLLEPDSGNKLGESKGMEEQDTLGGALAREAAEDEAGTDGKMELDREEKEEPSKSATLLWLIQKLTRTAKLEAAYTPRNPLKRTCIFKFLGAVAVDLGVDRVQPYLPVIIAPLFRELNSTYSEQDPLLKNLSQEIIELLRKLVGLESFSLAFASVQKQASEKRALRKKRKALEFVTNPDVAAKKKLKKHKNKSEAKKRKIEFLRPGYKAKRQKSHSLRDLAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H6X1</accession>
    <name>A0A3L7H6X1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TLR4 interactor with leucine rich repeats</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Tril</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027285453.1">
        <property type="nucleotide sequence ID" value="XM_027429652.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H6X1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008148.1">
        <property type="protein sequence ID" value="ENSCGRP00001005308.1"/>
        <property type="gene ID" value="ENSCGRG00001006970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764461"/>
    <dbReference type="KEGG" id="cge:100764461"/>
    <dbReference type="CTD" id="9865"/>
    <dbReference type="GeneTree" id="ENSGT00940000161975"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
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        </location>
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        <source>
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</entry>
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    </organism>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
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        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027283721.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12320" checksum="C60AA8109B2864DE" modified="2019-02-13" version="1">MNASFLNHSGLEEAGGDARAALGNRSHGLGTWLDCCPGGAPLTASDGVPAGLEPDERSLWVSRVAQIAVLCVLSLTVVFGVFFLGCNLLIKSESMINFLMQERRPSKDVGAAILGLY</sequence>
</entry>
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    <accession>A0A3L7HJ17</accession>
    <name>A0A3L7HJ17_CRIGR</name>
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        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">V-ATPase 28 kDa accessory protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Atp6v1d</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with SNX10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">Clathrin-coated vesicle membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007623615.1">
        <property type="nucleotide sequence ID" value="XM_007625425.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274155.1">
        <property type="nucleotide sequence ID" value="XM_027418354.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HJ17"/>
    <dbReference type="SMR" id="A0A3L7HJ17"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020512.1">
        <property type="protein sequence ID" value="ENSCGRP00001016268.1"/>
        <property type="gene ID" value="ENSCGRG00001016651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762500"/>
    <dbReference type="KEGG" id="cge:100762500"/>
    <dbReference type="CTD" id="51382"/>
    <dbReference type="GeneTree" id="ENSGT00390000010770"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027274155.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28390" checksum="3757CE09A12E9A08" modified="2019-02-13" version="1">MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKIIKEKFEKELEYRRAAGEVMEPANLLAEEKDEDLLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HKZ3</accession>
    <name>A0A3L7HKZ3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline rich 22</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Proline-rich protein 22 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Prr22</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027272617.1">
        <property type="nucleotide sequence ID" value="XM_027416816.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HKZ3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028463.1">
        <property type="protein sequence ID" value="ENSCGRP00001024217.1"/>
        <property type="gene ID" value="ENSCGRG00001022202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772837"/>
    <dbReference type="KEGG" id="cge:100772837"/>
    <dbReference type="CTD" id="163154"/>
    <dbReference type="GeneTree" id="ENSGT00390000016128"/>
    <dbReference type="OrthoDB" id="9941921at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031535">
        <property type="entry name" value="PRR22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37871">
        <property type="entry name" value="PROLINE-RICH PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37871:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15776">
        <property type="entry name" value="PRR22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027272617.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="43698" checksum="BBF5A35ECACC587D" modified="2019-02-13" version="1">MQHPKTLYPPAIPQEGFGPRGLEGTEVPGGPEPLPTVASASLLYQTPGSDHDVLSAPPAGFQMAPCGCFFDPRIYRIEWATSDFGQSSLYKVAVAGGPTLSSGYLLEAPSYLKAPGPPPPLYPHYQPAPGGPQYLTHYLPPEESGPEAVGFVGDGGSLNFMEMLRDGLAPPPTPKETKPSPLLITVPTAHSLPPGPYGHLSGHASQFPGPQVTMRPIEAPRELQGSAVARLGLRFPPGPAEPKVAEVEDITPMGSGETVPPEVARAFFLPDKVLLEDAMKLFDCLPGGAEPEVALHRGTGPSPRDSGGGGDDCTADIRSLHLPDELLSFDYGVPEVLDAVASVDYVFSFKALDDEPLPHVGVPVTDMVAPGLRSHQSGKKTTTSTKKGKPGGRQRQTTGPAGTTTTGPRPDPGTALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I7I9</accession>
    <name>A0A3L7I7I9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Med10</name>
        <name evidence="11" type="synonym">MED10</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007640532.1">
        <property type="nucleotide sequence ID" value="XM_007642342.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255924.1">
        <property type="nucleotide sequence ID" value="XM_027400123.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I7I9"/>
    <dbReference type="SMR" id="A0A3L7I7I9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018035.1">
        <property type="protein sequence ID" value="ENSCGRP00001013798.1"/>
        <property type="gene ID" value="ENSCGRG00001014842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759421"/>
    <dbReference type="KEGG" id="cge:100759421"/>
    <dbReference type="CTD" id="84246"/>
    <dbReference type="GeneTree" id="ENSGT00390000014501"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027255924.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15661" checksum="61143396990FA91F" modified="2019-02-13" version="1">MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IED2</accession>
    <name>A0A3L7IED2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calponin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Cnn3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007648739.1">
        <property type="nucleotide sequence ID" value="XM_007650549.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251422.1">
        <property type="nucleotide sequence ID" value="XM_027395621.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IED2"/>
    <dbReference type="SMR" id="A0A3L7IED2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020531.1">
        <property type="protein sequence ID" value="ENSCGRP00001016287.1"/>
        <property type="gene ID" value="ENSCGRG00001016661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773931"/>
    <dbReference type="KEGG" id="cge:100773931"/>
    <dbReference type="CTD" id="1266"/>
    <dbReference type="GeneTree" id="ENSGT00940000154539"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21284">
        <property type="entry name" value="CH_CNN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000040">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF17">
        <property type="entry name" value="CALPONIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027251422.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36461" checksum="FEF23BEF82617335" modified="2019-02-13" version="1">MTHFNKGPSYGLSAEVKNKIASKYDQQAEEDLRNWIEEVTGMGIGTNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYPEDYPREYQYGDDQGIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LK08</accession>
    <name>A0A8C2LK08_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase like 9</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methyltransferase-like protein 9 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Mettl9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027266039.1">
        <property type="nucleotide sequence ID" value="XM_027410238.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LK08"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006679.1">
        <property type="protein sequence ID" value="ENSCGRP00001004452.1"/>
        <property type="gene ID" value="ENSCGRG00001005667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760354"/>
    <dbReference type="KEGG" id="cge:100760354"/>
    <dbReference type="CTD" id="51108"/>
    <dbReference type="GeneTree" id="ENSGT00390000013648"/>
    <dbReference type="OrthoDB" id="199041at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
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        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678545" evidence="1">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027266039.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36428" checksum="42D734057F7815B4" modified="2022-01-19" version="1">MRLLAGWLCLSLASVWLARRMWTLRSPLSRSLYVNMTSGPGGPAASAGGGKDTHQWYVCNREKLCESLQSVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTQGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVFVLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LK34</accession>
    <name>A0A8C2LK34_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Beta-secretase 2 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="23">Beta-site APP-cleaving enzyme 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Bace2</name>
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    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027271511.1">
        <property type="nucleotide sequence ID" value="XM_027415710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LK34"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008004.1">
        <property type="protein sequence ID" value="ENSCGRP00001005231.1"/>
        <property type="gene ID" value="ENSCGRG00001006826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764950"/>
    <dbReference type="KEGG" id="cge:100764950"/>
    <dbReference type="CTD" id="25825"/>
    <dbReference type="GeneTree" id="ENSGT00940000159548"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050435">
        <property type="term" value="P:amyloid-beta metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glucose homeostasis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:melanosome organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05473">
        <property type="entry name" value="beta_secretase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-secretase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000007">
        <property type="entry name" value="Beta-secretase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009119">
        <property type="entry name" value="BACE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009121">
        <property type="entry name" value="BACE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033874">
        <property type="entry name" value="Memapsin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF40">
        <property type="entry name" value="BETA-SECRETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01817">
        <property type="entry name" value="BACE2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01815">
        <property type="entry name" value="BACEFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="15 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 19" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678547" evidence="21">
        <location>
            <begin position="24"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="22">
        <location>
            <begin position="88"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="18">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="18">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="229"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="288"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR609121-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR609121-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027271511.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="55602" checksum="C95782D5A752D73C" modified="2022-01-19" version="1">MGAQLRALLLPLLAQWLLRATTALAPAPFTLPLQVSAATSLVASAVPGLGTPEKPRADGLALALEPSGAAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGAPHSYVDSYFDSERSSTYHPKGFDVTVKYTQGSWTGIVGEDIVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISSSTNALVIGATVMEGFYVVFDRARKRVGFAASPCAEIEGTTVSEISGPFSTEDVASNCVPAPALNEPILWIVSYALMSVCGAILLVLILLLLLPVRCRHAPRDPEVVNDESSLVRHRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LLJ8</accession>
    <name>A0A8C2LLJ8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TLC domain containing 3A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">TLC domain-containing protein 3A isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Tlcd3a</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027282511.1">
        <property type="nucleotide sequence ID" value="XM_027426710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LLJ8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007506.1">
        <property type="protein sequence ID" value="ENSCGRP00001004939.1"/>
        <property type="gene ID" value="ENSCGRG00001006396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763695"/>
    <dbReference type="KEGG" id="cge:100763695"/>
    <dbReference type="CTD" id="79850"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF20">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678558" evidence="7">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="33"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027282511.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29435" checksum="08FE0C8CBE7FA65F" modified="2022-01-19" version="1">MLLTLASGALFFPGLFALSTWALRRSRPEWTDDDCLTVGTRLVSSVQAVLATGAGLTIICSCSNVVSDRHWLAREYVWFLIPYMIYDCYAMYLCEWCRTRDQKLRRATIFRNFLIENRLMVTHHAVILFVLVPVSQKLRGELGDFFVGCIFTAELSTPFVSLGRVLIQLKQQHTLLYKVNGILTLSTFLFCRILLFPFMYWSYGQHKGLSLLRVPFNIPLHCNVANAILISPQLYWFSLLCKKAARLFDTAKAKKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LM79</accession>
    <name>A0A8C2LM79_CRIGR</name>
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        <recommendedName>
            <fullName evidence="3">Cohesin subunit SA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">SCC3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Stromal antigen</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10 11 12" type="primary">Stag2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10 11 12">17A/GY</strain>
            <tissue evidence="10 11 12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SCC3 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027433514.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027433515.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289317.1">
        <property type="nucleotide sequence ID" value="XM_027433516.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LM79"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009568.1">
        <property type="protein sequence ID" value="ENSCGRP00001006123.1"/>
        <property type="gene ID" value="ENSCGRG00001008159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757438"/>
    <dbReference type="KEGG" id="cge:100757438"/>
    <dbReference type="CTD" id="10735"/>
    <dbReference type="GeneTree" id="ENSGT00950000182972"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF3">
        <property type="entry name" value="COHESIN SUBUNIT SA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="6">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1062"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027289315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027289316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027289317.1"/>
        </source>
    </evidence>
    <sequence length="1268" mass="145722" checksum="47B563AE1E08DD4D" modified="2022-01-19" version="1">MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCKKGKKGAVEKGKSGNGGGKPPSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSRRDPEEDGIMKRRGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMNSLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIVEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEPDEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCTHYVILWQLAKVTESSSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIFSHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDSNSADGQQEDEASKIEALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGMSSRGSTVRSKKSKPSTGKRKVVEGMQLALPEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMSVYPMQTEHHQTPLDYNTQVTWMLAQRQQEEARQQQERAAMSYVKLRTNLQHAIRRGTSLMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPPSKNRRERTELKPDFFDPASIMDESVLGVSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LSF0</accession>
    <name>A0A8C2LSF0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/bile acid cotransporter 5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Solute carrier family 10 (sodium/bile acid cotransporter family), member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Slc10a5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003510120.1">
        <property type="nucleotide sequence ID" value="XM_003510072.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254562.1">
        <property type="nucleotide sequence ID" value="XM_027398761.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LSF0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009050.1">
        <property type="protein sequence ID" value="ENSCGRP00001005841.1"/>
        <property type="gene ID" value="ENSCGRG00001007748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760229"/>
    <dbReference type="KEGG" id="cge:100760229"/>
    <dbReference type="CTD" id="347051"/>
    <dbReference type="GeneTree" id="ENSGT00950000182808"/>
    <dbReference type="OMA" id="AWMAHFR"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008508">
        <property type="term" value="F:bile acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057103">
        <property type="entry name" value="NTCP5_P3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF29">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24690">
        <property type="entry name" value="NTCP5_P3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678659" evidence="9">
        <location>
            <begin position="19"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="NTCP5/P3 N-terminal" evidence="10">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027254562.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="47883" checksum="99CDAD7BFEA823A5" modified="2022-01-19" version="1">MFGNFFLILLLLVTPGEARKSFLSFLNIQNTEILSFAKTEETVVVRSSYKDKRPNSSYLFVKLEDPKVLQVVNVTKTLLDVTDFTISLMTSPGETNLTIQLWDSEGRQKILIEEIKNVKVKVLLQTKGSLFQAPMHVNRYILMLILSMVLLNKCAFGCKIEFQVLQTVWKKPLPVVLGTVTQFFLMPFCGFLLSQIFGLSKAQAFGFVLTCTCPGGGGGYLFALLLEGDITLAILMTCTSTTLALIMMPVNSYLYSRLLGLPGVFHVPVLKIVSTLLFILTPISIGVVIKHKTPQKAACLERVVRPLSLTLMFVGIYLAFRMGLVFLRMANLDMLLLGLLVPALGFLFGYSFAKVSMLPLPVCKTVAIESGMLNSFLALAIIQLSFSQSKAYEASVAPFTTAMCSGCEMLLLLLIYKGKKRGILSTGTEKTPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LTK4</accession>
    <name>A0A8C2LTK4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gamma-2-syntrophin isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Syntrophin, gamma 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Sntg2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntrophin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027280535.1">
        <property type="nucleotide sequence ID" value="XM_027424734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LTK4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009847.1">
        <property type="protein sequence ID" value="ENSCGRP00001006286.1"/>
        <property type="gene ID" value="ENSCGRG00001008435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752603"/>
    <dbReference type="KEGG" id="cge:100752603"/>
    <dbReference type="CTD" id="54221"/>
    <dbReference type="GeneTree" id="ENSGT00950000182863"/>
    <dbReference type="OrthoDB" id="9975356at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016013">
        <property type="term" value="C:syntrophin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097109">
        <property type="term" value="F:neuroligin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06801">
        <property type="entry name" value="PDZ_syntrophin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000080">
        <property type="entry name" value="Syntrophin gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF3">
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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    <sequence length="540" mass="59899" checksum="326D8AE5DFAD5495" modified="2022-01-19" version="1">MSAEGSQSLAAPRGRPSHLLVPARTKTALALLYDEALENAYDVRLKLTKEVLTIQKQDVVCIGGAPPGANHRTVTLRRQPVGGLGLSIKGGAEHGVPVVISKIFKDQAADQTEMLFIGDAVLQVNGINVENATHEEVVHLLRTAGDDVTITVEYLREAPSFLKLPLGSPGPSSDHSSRASSPLFDSGLHLNGHCSHTAPSSPSSPIANEPKYEKRWLDTLSVPLSMARISRYKAGAEKLRSSAFEVLALDGTSTGVLQFSTNQDCADWLRAISANISDLTLQHMKMANKCCSPCDQVVHMGWVNERLQRADDTSQIFRSKFLALKGSSFFIFSTPPVSTLDWGRAERAYNLCEVLFKVHKFWLSDNYWLQANFYLGLHDFDCEDPRPYCFSVLASHGKSHNFSVELGSELAVWEKSFQRATFMEVQRTGSKTYLCSWQGEMLCFTVDFALGFTCFDGKTKNVLWRFKFSQLKGSSDDGKTRVKLLFQNLDTKQIETKELEFQDLTAVLHCIHSFIAAKVASLDPAFMDSQSMARRYMCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LTY0</accession>
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        <submittedName>
            <fullName evidence="5">Brain abundant, membrane attached signal protein 1</fullName>
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        <submittedName>
            <fullName evidence="8">LOW QUALITY PROTEIN: brain acid soluble protein 1-like</fullName>
        </submittedName>
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        <name evidence="5 8" type="primary">LOC113833947</name>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">17A/GY</strain>
        </source>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the BASP1 family.</text>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
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</entry>
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            <taxon>Mammalia</taxon>
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            <taxon>Rodentia</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003497585.1">
        <property type="nucleotide sequence ID" value="XM_003497537.4"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027391305.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LX43"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011789.1">
        <property type="protein sequence ID" value="ENSCGRP00001007722.1"/>
        <property type="gene ID" value="ENSCGRG00001010106.1"/>
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    <dbReference type="GeneID" id="100756119"/>
    <dbReference type="KEGG" id="cge:100756119"/>
    <dbReference type="CTD" id="136263"/>
    <dbReference type="GeneTree" id="ENSGT00390000015907"/>
    <dbReference type="OrthoDB" id="9367609at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027955">
        <property type="entry name" value="DUF4636"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31822">
        <property type="entry name" value="SERINE-RICH SINGLE-PASS MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31822:SF1">
        <property type="entry name" value="SERINE-RICH SINGLE-PASS MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15468">
        <property type="entry name" value="DUF4636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027247106.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27932" checksum="054D4272C9331A43" modified="2022-01-19" version="1">MGDLLSLFWEVDPPPMPISFAIPSQDAECRKDESCGTIGSFLLWYFVIILILMLFSRASVWMSESKRDEDSGTSASVSRASKETSYKRQSKDGPWDSSQVMKKPKQNQLSTVTDSEVALVNAYLEQRGGRRHSQFHRVNQTQQDSDSTECDSEESNSGASSWKESESEHHPLPTSIKRRKPVSRPREVVENYQIRERPCLHCKAMRTNEWLTRHFPPSTSVTTPMKGEIQEENLTPSINTKLSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LZN7</accession>
    <name>A0A8C2LZN7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Fucosyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Fut4</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes alpha(1-&gt;3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1-&gt;4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1-&gt;4)-[alpha-L-fucosyl-(1-&gt;3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14257"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:137941"/>
            <dbReference type="EC" id="2.4.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:14258"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56076"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:136545"/>
            <dbReference type="ChEBI" id="CHEBI:139509"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:56077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68044"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:145343"/>
            <dbReference type="ChEBI" id="CHEBI:176900"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:68045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc6S derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:145344"/>
            <dbReference type="ChEBI" id="CHEBI:145345"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:62005"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Golgi apparatus</location>
            <location evidence="1 18">Golgi stack membrane</location>
            <topology evidence="1 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="RefSeq" id="XP_027266625.1">
        <property type="nucleotide sequence ID" value="XM_027410824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LZN7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016351.1">
        <property type="protein sequence ID" value="ENSCGRP00001012118.1"/>
        <property type="gene ID" value="ENSCGRG00001013612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754814"/>
    <dbReference type="KEGG" id="cge:100754814"/>
    <dbReference type="CTD" id="2526"/>
    <dbReference type="GeneTree" id="ENSGT00940000162506"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017083">
        <property type="term" value="F:4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097022">
        <property type="term" value="P:lymphocyte migration into lymph node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903238">
        <property type="term" value="P:positive regulation of leukocyte tethering or rolling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902624">
        <property type="term" value="P:positive regulation of neutrophil migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000001">
        <property type="entry name" value="alpha-(1,3)-fucosyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF132">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="20">
        <location>
            <begin position="91"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="19">
        <location>
            <begin position="255"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027266625.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48922" checksum="0A9445162755E8D0" modified="2022-01-19" version="1">MALAGHERQYESRCRPSRSVDAWRAEAAAPGPCMGTPGTRQRARVRPGWRLRRSSSALAAAGLLCTALTACICWGQLPPLPWASPAPPRPVGVLLWWEPFGGRGGHPRSPPDCSLRFNISGCRLLTDRAAYGEAQAVLFHHRDLVTGLSDWPPPWGAQVRRDEALEQRVFDDQEGAAMLAGEALETAGSRPPGQRWVWMNFESPSHSPGLRGLAKNLFNWTLSYRADSDVFVPYGFLYPRSHPTDQPPGLSPPLARKRGLVAWVVSHWDERQARVRYYRQLIQHVPVDVFGRAAVGKPVPASGLLHTVARYKFYLAFENSQHVDYITEKLWRNAFLAGAVPVVLGPDRANYERFVPRGSFIHVDDFPSAASLAAYLLFLDRNLAVYRRYFHWRRSYAVHITSFWDEPWCRTCQAVQTSGDQPKSIQNLASWFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M1F9</accession>
    <name>A0A8C2M1F9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Hexosyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">B3galnt2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-Man]-L-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37667"/>
            <dbReference type="Rhea" id="RHEA-COMP:13308"/>
            <dbReference type="Rhea" id="RHEA-COMP:13618"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:136709"/>
            <dbReference type="ChEBI" id="CHEBI:137540"/>
            <dbReference type="EC" id="2.4.1.313"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_027265228.1">
        <property type="nucleotide sequence ID" value="XM_027409427.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316647.1">
        <property type="nucleotide sequence ID" value="XM_035460756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M1F9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013599.1">
        <property type="protein sequence ID" value="ENSCGRP00001009391.1"/>
        <property type="gene ID" value="ENSCGRG00001011516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768564"/>
    <dbReference type="KEGG" id="cge:100768564"/>
    <dbReference type="CTD" id="148789"/>
    <dbReference type="GeneTree" id="ENSGT00940000156562"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008376">
        <property type="term" value="F:acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000013">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF219">
        <property type="entry name" value="UDP-GALNAC:BETA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678701" description="Hexosyltransferase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027265228.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57034" checksum="19BA9040DEF4671D" modified="2022-01-19" version="1">MRNWLVLLCPCVLGAALHLWHLWLRSPPPPRASGPGAAGQSALFPESKFSHYDVVVGVLSARNNHELRNVIRNTWLKHLLQHPTLSQRVLVKFIIGARGCEVPVEDREDPYSCRLLNITNPVLNQEIEAFSFPEEASSPRLSEDRVVSVSFRVLYPIVITSLGVFYDANDIGFQRNITVKLYQAEQEEALFIARFSPPSCGIQVNKLWYKPVEQFILPESFEGTIVWESQDLHGLVSRNLHRVTVNDGGGVLRVITAGEGTLPHEFMEGVEGVAGGFIYTVQEGDALLRSLHSRPQRLSDHIQDLRVEDALLQEESSIYDDIVFVDVVDTYRNVPAKLLNFYRWTVETTSFSLLLKTDDDCYIDLEAVFNRIAQKNLDGPNFWWGNFRLNWAVDRTGKWQELEYPSPAYPAFACGSGYVISKDIVDWLAGNSGRLKTYQGEDVSMGIWMAAIGPKRHQDTLWLCEKTCETGMLSSPQYSPQELSRLWELKELCGDPCQCEAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M2G8</accession>
    <name>A0A8C2M2G8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase RNF166</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">RING finger protein 166</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RING-type E3 ubiquitin transferase RNF166</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Rnf166</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_016818644.2">
        <property type="nucleotide sequence ID" value="XM_016963155.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266462.1">
        <property type="nucleotide sequence ID" value="XM_027410661.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M2G8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016098.1">
        <property type="protein sequence ID" value="ENSCGRP00001011865.1"/>
        <property type="gene ID" value="ENSCGRG00001013400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754557"/>
    <dbReference type="KEGG" id="cge:100754557"/>
    <dbReference type="CTD" id="115992"/>
    <dbReference type="GeneTree" id="ENSGT00950000182909"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16549">
        <property type="entry name" value="RING-HC_RNF166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051438">
        <property type="entry name" value="RNF_E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034734">
        <property type="entry name" value="ZF_C2HC_RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18574">
        <property type="entry name" value="zf_C2HC_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51803">
        <property type="entry name" value="ZF_C2HC_RNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC RNF-type" evidence="16">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027266462.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26162" checksum="98CAAE7C6F271473" modified="2022-01-19" version="1">MAMFRSLVASAQQRQPPAGPASGDSGLEAQFSCPICLEVYYRPVAIGSCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSCLKVQEQMANCPKFVPVLPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M7T8</accession>
    <name>A0A8C2M7T8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="17">ATP-PFK</shortName>
            <shortName evidence="17">Phosphofructokinase</shortName>
            <ecNumber evidence="17">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Pfkl</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17 18">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="17">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17 18">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homo- and heterotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="17"/>
    <dbReference type="RefSeq" id="XP_027250137.1">
        <property type="nucleotide sequence ID" value="XM_027394336.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M7T8"/>
    <dbReference type="SMR" id="A0A8C2M7T8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019280.1">
        <property type="protein sequence ID" value="ENSCGRP00001015041.1"/>
        <property type="gene ID" value="ENSCGRG00001015753.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762127"/>
    <dbReference type="KEGG" id="cge:100762127"/>
    <dbReference type="CTD" id="5211"/>
    <dbReference type="GeneTree" id="ENSGT00940000159292"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070061">
        <property type="term" value="F:fructose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046676">
        <property type="term" value="P:negative regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00764">
        <property type="entry name" value="Eukaryotic_PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000001">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000043">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase, platelet type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041914">
        <property type="entry name" value="PFK_vert-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF14">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 17" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17 18" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="402"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="17">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="17">
        <location>
            <begin position="401"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="527"/>
            <end position="531"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="572"/>
            <end position="574"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <begin position="660"/>
            <end position="663"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="17">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027250137.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="85369" checksum="043A3D0BCDAF1DFB" modified="2022-01-19" version="1">MATVDLEKLRMSGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKPANWLSVSNIIQLGGTIIGSARCKAFTTREGRLAAAYNLLQHGITNLCVIGGDGSLTGANVFRSEWGSLLEELVKEGKISESTAQKHAHLSIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRHGKPISSNYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRVLSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQVTKEVQKAMDEKRFDEAIQLRGRSFENNWKIYKLLAHQKVSKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISEGHTVYVVHDGFEGLAKGQVQEVSWHDVAGWLGRGGSMLGTKRTLPKLHLEAIVENLRTYNIHALLVIGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKANVEHMTEKMKTDIQRGLVLRNEKCHEHYTTEFLYNLYSSEGRGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWMSEKLRDVYRKGRVFANAPDSACVIGLRKKVVAFSPVTELKKDTDFEHRMPREQWWLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIDKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MF78</accession>
    <name>A0A8C2MF78_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL35m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L35, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Mrpl35</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003503938.1">
        <property type="nucleotide sequence ID" value="XM_003503890.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285324.1">
        <property type="nucleotide sequence ID" value="XM_027429523.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MF78"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020572.1">
        <property type="protein sequence ID" value="ENSCGRP00001016328.1"/>
        <property type="gene ID" value="ENSCGRG00001016701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762335"/>
    <dbReference type="KEGG" id="cge:100762335"/>
    <dbReference type="CTD" id="51318"/>
    <dbReference type="OMA" id="TYCSTRK"/>
    <dbReference type="OrthoDB" id="5847109at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019338">
        <property type="entry name" value="Ribosomal_bL35m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027285324.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21661" checksum="B4BC21E997864E12" modified="2022-01-19" version="1">MAASVFTGALRAASGILRPLNVLASSTYRNYAKNACLTSALCTIHFRHIQTPVVSFAPRLVTSVRNLTHGHTATVLNRVAALVPSVLKPPVRTLTYCSTRKGKRKTVKSVVHRFLRLHSGLWLRRKAGYKKKLWKKSTARKKRLREFVFCNKTQSKLLDKMTTSFWKRRNWYADDPYLMYHDRTNLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJY0</accession>
    <name>A0A8C2MJY0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger protein 709 isoform X10</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 866</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">LOC100762310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027250388.1">
        <property type="nucleotide sequence ID" value="XM_027394587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MJY0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024469.1">
        <property type="protein sequence ID" value="ENSCGRP00001020225.1"/>
        <property type="gene ID" value="ENSCGRG00001019443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762310"/>
    <dbReference type="GeneTree" id="ENSGT00950000182755"/>
    <dbReference type="OrthoDB" id="3156061at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000165">
        <property type="entry name" value="Zinc finger protein 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001254">
        <property type="entry name" value="Zinc finger protein 564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002859">
        <property type="entry name" value="Zinc finger protein 866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF133">
        <property type="entry name" value="ZFP617 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027250388.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="60669" checksum="E91970450C186D54" modified="2022-01-19" version="1">MDLVSFEDVAVHFTQEEWTLLDPSQKSLYRDVMLETCRNLAAIGYIWEEQNIEDDCKNFGRYQRHLTSHSEYMPYEHEEYGNTPYDSSSLTSIQGYMAAHTVNGPCECEVCLKSFGFSSTLGIYHQTHSGENFYDYKECGKASVYHSSLYTHGGTHTVRKCYECNQCGKVLSSSSSLQRHERIHTGERPYKCNQCGKALSSSTSLQRHERIHTGERPYKCNQCGKAFRCHSALQLHERIHTGEKPYECQQCGKAFTCHSYLRLHERTHTGEKPYECKQCGKAFRCQTSYHRHKIIHGGETFYECKQCSRLFIYPSLLQMHERTHTSERPYKCKQCGKSFLYPSLLQMHERTHTGEKPYECKECGTAFRHHSSLRLHERTHTGEKPYECQQCGKAFTRHTSLRLHEITHTGEKPYKCKECGKAFRHHSSLRLHGRIHSGEKPYECKQCDKAFIRYSYLRLHERTHTGEKPYECKQCGKAFSRHSSFQRHKSIHAVESPFECQQYLIPLSLFPPNTSDNAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MM31</accession>
    <name>A0A8C2MM31_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dehydrogenase/reductase SDR family member 4</fullName>
            <ecNumber evidence="6">1.1.1.184</ecNumber>
            <ecNumber evidence="2">1.1.1.300</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">NADPH-dependent carbonyl reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADPH-dependent retinol dehydrogenase/reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Peroxisomal short-chain alcohol dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Short chain dehydrogenase/reductase family 25C member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">LOC100771290</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) = 5beta-pregnan-3,20-dione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69016"/>
            <dbReference type="ChEBI" id="CHEBI:1712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30154"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:69017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5beta-dihydrotestosterone + NADPH + H(+) = 5beta-androstane-3alpha,17beta-diol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:69028"/>
            <dbReference type="ChEBI" id="CHEBI:2150"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36714"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:69029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NADP(+) = a ketone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19257"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.184"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:19259"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25033"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.300"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:25035"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:68609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="6"/>
    <dbReference type="EC" id="1.1.1.300" evidence="2"/>
    <dbReference type="RefSeq" id="XP_027246378.1">
        <property type="nucleotide sequence ID" value="XM_027390577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MM31"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023484.1">
        <property type="protein sequence ID" value="ENSCGRP00001019240.1"/>
        <property type="gene ID" value="ENSCGRG00001018739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771290"/>
    <dbReference type="KEGG" id="cge:100771290"/>
    <dbReference type="GeneTree" id="ENSGT00940000158919"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001758">
        <property type="term" value="F:retinal dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08936">
        <property type="entry name" value="CR_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943:SF8">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027246378.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="29806" checksum="A57DE5A654913637" modified="2022-01-19" version="1">MQRAGLLLSGWTQAWKSVRMASYGVTRQNPLANKVALVTASTDGIGFAIARRLAEDGAHVVISSRKQENVNRAVATLQGEGLSVTGIVCHVGKQEDRERLVTTAVKLHHGIDILVSNAAVNPFFGNLLDVTEEVWDKVLSINVTATAMLIKAVVPEMEKRGGGSVVIVGSVAGFTPFPFLGPYNVSKAALLSLTKNYAAELASKNVRVNCLAPGLIKTRFSSALWKDGSKEDIIKERMQIRRLGKPEDCAGIVSFLCSEDASYISGETVVVGGGTPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MP60</accession>
    <name>A0A8C2MP60_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Adrenal ferredoxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Ferredoxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Fdx1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with CYP11A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003502805.1">
        <property type="nucleotide sequence ID" value="XM_003502757.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270907.1">
        <property type="nucleotide sequence ID" value="XM_027415106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MP60"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025753.1">
        <property type="protein sequence ID" value="ENSCGRP00001021509.1"/>
        <property type="gene ID" value="ENSCGRG00001020345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751853"/>
    <dbReference type="KEGG" id="cge:100751853"/>
    <dbReference type="CTD" id="2230"/>
    <dbReference type="GeneTree" id="ENSGT00940000156916"/>
    <dbReference type="OMA" id="VARNCIR"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904322">
        <property type="term" value="P:cellular response to forskolin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000013">
        <property type="entry name" value="Adrenodoxin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF26">
        <property type="entry name" value="ADRENODOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="14" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027270907.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20290" checksum="BBAE582A16A7E0FF" modified="2022-01-19" version="1">MAAAPGARLLRAACASVAFRGLDRRWLLVCGVRAGTAVPQWTPSPGMLAEAGRGRPLSVSARAWSSSEDKITVHFKNRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQVCLTKAMDNMTVRVPEAVADVRQSIDMSKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQD7</accession>
    <name>A0A8C2MQD7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T cell leukemia, homeobox 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">T-cell leukemia homeobox protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Tlx1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027262992.1">
        <property type="nucleotide sequence ID" value="XM_027407191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MQD7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026783.1">
        <property type="protein sequence ID" value="ENSCGRP00001022538.1"/>
        <property type="gene ID" value="ENSCGRG00001021053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751022"/>
    <dbReference type="KEGG" id="cge:100751022"/>
    <dbReference type="CTD" id="3195"/>
    <dbReference type="OrthoDB" id="9451579at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000040">
        <property type="entry name" value="T-cell leukemia homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042247">
        <property type="entry name" value="TLX1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921">
        <property type="entry name" value="IP01054P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921:SF2">
        <property type="entry name" value="T-CELL LEUKEMIA HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="201"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="203"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027262992.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="34371" checksum="171783CBDBFA4FF5" modified="2022-01-19" version="1">MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGSSAAGAGAGATGAYGAGGPGGPGGPAGGGGGGACSMGPLAGSYNVNMALAGGPGPGGGGGGAGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAVPGVNNLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQX8</accession>
    <name>A0A8C2MQX8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vinculin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Metavinculin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Vcl</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
            <location evidence="5">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <location evidence="4">Sarcolemma</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003496777.1">
        <property type="nucleotide sequence ID" value="XM_003496729.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243318.1">
        <property type="nucleotide sequence ID" value="XM_027387517.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MQX8"/>
    <dbReference type="SMR" id="A0A8C2MQX8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026565.1">
        <property type="protein sequence ID" value="ENSCGRP00001022320.1"/>
        <property type="gene ID" value="ENSCGRG00001020879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759958"/>
    <dbReference type="KEGG" id="cge:100759958"/>
    <dbReference type="CTD" id="7414"/>
    <dbReference type="GeneTree" id="ENSGT01030000234543"/>
    <dbReference type="OrthoDB" id="29742at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043034">
        <property type="term" value="C:costamere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005916">
        <property type="term" value="C:fascia adherens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061826">
        <property type="term" value="C:podosome ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045294">
        <property type="term" value="F:alpha-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002162">
        <property type="term" value="F:dystroglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043297">
        <property type="term" value="P:apical junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090136">
        <property type="term" value="P:epithelial cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903140">
        <property type="term" value="P:regulation of establishment of endothelial barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904702">
        <property type="term" value="P:regulation of protein localization to adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000041">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000010">
        <property type="entry name" value="Vinculin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.810:FF:000001">
        <property type="entry name" value="Vinculin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000013">
        <property type="entry name" value="Vinculin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.810:FF:000002">
        <property type="entry name" value="Vinculin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.810:FF:000003">
        <property type="entry name" value="Vinculin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017997">
        <property type="entry name" value="Vinculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46180">
        <property type="entry name" value="VINCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00806">
        <property type="entry name" value="VINCULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00663">
        <property type="entry name" value="VINCULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00664">
        <property type="entry name" value="VINCULIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="857"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="860"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027243318.1"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123829" checksum="CDC4936A54AF4E97" modified="2022-01-19" version="1">MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQADPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEIAALTSKLGDLRRQGKGDSPEARALAKQVATALQNLQSKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAQMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGRLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAQVGIGVVAEADAADAVGFPFPSDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MRN2</accession>
    <name>A0A8C2MRN2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoinositide 3-kinase adapter protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">B-cell adapter for phosphoinositide 3-kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">B-cell phosphoinositide 3-kinase adapter protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Pik3ap1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homooligomer. Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase. Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. May interact with MYD88 and TIRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027263137.1">
        <property type="nucleotide sequence ID" value="XM_027407336.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MRN2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026851.1">
        <property type="protein sequence ID" value="ENSCGRP00001022606.1"/>
        <property type="gene ID" value="ENSCGRG00001021098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764327"/>
    <dbReference type="KEGG" id="cge:100764327"/>
    <dbReference type="CTD" id="118788"/>
    <dbReference type="GeneTree" id="ENSGT00390000008787"/>
    <dbReference type="OrthoDB" id="8192811at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036312">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034134">
        <property type="term" value="P:toll-like receptor 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034154">
        <property type="term" value="P:toll-like receptor 7 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034162">
        <property type="term" value="P:toll-like receptor 9 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000010">
        <property type="entry name" value="phosphoinositide 3-kinase adapter protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052446">
        <property type="entry name" value="B-cell_PI3K-Signaling_Adptrs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017893">
        <property type="entry name" value="DBB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041340">
        <property type="entry name" value="PIK3AP1_TIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267">
        <property type="entry name" value="BANK1/PIK3AP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267:SF12">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE ADAPTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14545">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18567">
        <property type="entry name" value="TIR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01282">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51376">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DBB" evidence="14">
        <location>
            <begin position="182"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="688"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027263137.1"/>
        </source>
    </evidence>
    <sequence length="811" mass="91124" checksum="AE0012E76E14D04C" modified="2022-01-19" version="1">MAASGWGRGCDILIFYSPDAEEWCQYLQDLFVSCRQVRSQKMQTYRLGPDASFSAEDLLVFRNARCMLVLLSAGLVECFCRPGLLPMLQRAFHPPRRVVRLLCGVQSRDENFQAFFPEWEHWQELTCDDEPETYLAAVRKAISEDSGCDSVTDTEPEDERVLPLSKQTNRPPEIPSGNLMVVQPDRIRCGAETTVYVIVRCKLDEKVATAAEFSPEDSPSIRVEGTLENEYTVSVKAPDLSSGSVCLKVYSGDLVVCETTISYYTDMEEIGNLLSSAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGNYPNTIAEKHGFRDLRQFIDEYVETVDMLKSHIKEELMQGEEADDVYESMAHLSTDLLMKCSLNPGCDEELYESMAAFAPEATEDLYVEMLQASAGNPGSGESFSRPTKDSMIRKFLEGNSVKSVGLERAQYHSQREDIYHTVDEDETFSVDLANRPPVPVPRPEASAPGPHPLPDNEPYISKVFAEKSQERLGNFYVSSENIRKEPPVRPWRDRPPSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKHADLEITVPIRHSQHLPGKVEFGVYESGPRKSVFPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEITRSRSPGPTQMDGAPAVTGTPVMTLERPPRVPPRAASQRPLTREPFPPPPPVPPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MVH8</accession>
    <name>A0A8C2MVH8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 19">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Mcm7</name>
        <name evidence="19" type="synonym">MCM7</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Interacts with the ATR-ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Interacts with ANKRD17. Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="RefSeq" id="XP_027271026.1">
        <property type="nucleotide sequence ID" value="XM_027415225.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297912.1">
        <property type="nucleotide sequence ID" value="XM_027442111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MVH8"/>
    <dbReference type="SMR" id="A0A8C2MVH8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025265.1">
        <property type="protein sequence ID" value="ENSCGRP00001021021.1"/>
        <property type="gene ID" value="ENSCGRG00001019986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770006"/>
    <dbReference type="KEGG" id="cge:100770006"/>
    <dbReference type="CTD" id="4176"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000007">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="332"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027271026.1"/>
        </source>
    </evidence>
    <sequence length="719" mass="81047" checksum="AB8521152E79FEEC" modified="2022-01-19" version="1">MALKDYAIEKEKVRKFLQEFYYDDELGKKQFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYSKLFADVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFQGPSSSKPRVIREVRADSVGKLVTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIPRSITVVLQGENTRTALPGDHVSVTGIFLPVLRTGFQQMAQGLLSETFLEAHRIVKMTKSEDDAAEAGELSGEELKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCRERQPTVPESLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMSKDSLLGEKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MX17</accession>
    <name>A0A8C2MX17_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">LOC100762374</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007650318.1">
        <property type="nucleotide sequence ID" value="XM_007652128.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287346.1">
        <property type="nucleotide sequence ID" value="XM_027431545.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MX17"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029504.1">
        <property type="protein sequence ID" value="ENSCGRP00001025258.1"/>
        <property type="gene ID" value="ENSCGRG00001022919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762374"/>
    <dbReference type="KEGG" id="cge:100762374"/>
    <dbReference type="GeneTree" id="ENSGT00390000012916"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF12">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027287346.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13513" checksum="183237C8F36F3AC8" modified="2022-01-19" version="1">MAGRPAVAASGKWLDGFRKWYYNAAGFNKLGLMRDDVMHETEDVKEAIRRLPENLYNDRMFRIKRALDLSMRHQILPKEQWTKYEEDKFYLEPYLKEVIRERKEKEEWAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MYA9</accession>
    <name>A0A8C2MYA9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biorientation of chromosomes in cell division 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Biorientation of chromosomes in cell division protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Bod1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BOD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027280972.1">
        <property type="nucleotide sequence ID" value="XM_027425171.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MYA9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029949.1">
        <property type="protein sequence ID" value="ENSCGRP00001025703.1"/>
        <property type="gene ID" value="ENSCGRG00001023221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750386"/>
    <dbReference type="KEGG" id="cge:100750386"/>
    <dbReference type="CTD" id="91272"/>
    <dbReference type="OrthoDB" id="7605699at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043244">
        <property type="entry name" value="BOD1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47391">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47391:SF1">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="5">
        <location>
            <begin position="109"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027280972.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25604" checksum="97C110AF9850FA02" modified="2022-01-19" version="1">MQRPPVTPLDRRQQRCERGAPWTPPPPTLPPPSPPPPWGPPCLRSAARGSRRSSRARGPARARGAAMADGAGAGGAGQASGPASGSSGAGGPVNPASLPPGDPQLIALIVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQSGMLEAGVDRIISQVVDPKLNHIFRPQIERAIHEFLAAQKKEAMPAPPPEPESQDPPAPSQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MYW3</accession>
    <name>A0A8C2MYW3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable RNA/DNA demethylase ALKBH6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alkylated DNA repair protein alkB homolog 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Alkbh6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable Fe(2+)/2-oxoglutarate-dependent dioxygenase involved in oxidative demethylation of nucleic acids. Binds nucleic acids with a preference for ssDNA or ssRNA to other types of DNAs. May play a role in nucleic acid damage repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with VCPKMT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027287083.1">
        <property type="nucleotide sequence ID" value="XM_027431282.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MYW3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029395.1">
        <property type="protein sequence ID" value="ENSCGRP00001025149.1"/>
        <property type="gene ID" value="ENSCGRG00001022841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771885"/>
    <dbReference type="KEGG" id="cge:100771885"/>
    <dbReference type="CTD" id="84964"/>
    <dbReference type="GeneTree" id="ENSGT00510000048626"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000007">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 20" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="96"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027287083.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26563" checksum="ED0C25E2C6E0D4C1" modified="2022-01-19" version="1">MEEQDARVPALEPFRVEKAPPLIYYVPDFISKEEEDYLLRQVFNAPKPKWTQLSGRKLQNWGGLPHPRGMVPERLPPWLQRYVDKVSDLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPTVSTISLGSHTVLDFYEPRQPEDDAPIEQPRPPPQPITSLLVEPRSLLVLRGTAYTHLLHGIAATLVDELDATSLPPNAAACQSALPGAHLVRGTRVSLTIRRVPRVLRASLLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QBZ4</accession>
    <name>A0A8C2QBZ4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exosome complex component CSL4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Exosome component 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Exosc1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC6. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with DDX60.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CSL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003497800.1">
        <property type="nucleotide sequence ID" value="XM_003497752.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263119.1">
        <property type="nucleotide sequence ID" value="XM_027407318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QBZ4"/>
    <dbReference type="SMR" id="A0A8C2QBZ4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000427.1">
        <property type="protein sequence ID" value="ENSCGRP00001000403.1"/>
        <property type="gene ID" value="ENSCGRG00001000335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757484"/>
    <dbReference type="KEGG" id="cge:100757484"/>
    <dbReference type="CTD" id="51013"/>
    <dbReference type="GeneTree" id="ENSGT00390000015287"/>
    <dbReference type="OMA" id="PMVPVGW"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000024">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000135">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="66"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027263119.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21408" checksum="4C56B9745083295B" modified="2022-01-19" version="1">MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLTKTSENGALPVVSVMRETESQLLPDVGAVVTCKVSSINSRFAKVHILYVGSTPLKNAFRGTIRKEDIRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGVQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QD88</accession>
    <name>A0A8C2QD88_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">C-&gt;U-editing enzyme APOBEC-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">Apobec4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_035301593.1">
        <property type="nucleotide sequence ID" value="XM_035445702.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312037.1">
        <property type="nucleotide sequence ID" value="XM_035456146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QD88"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005406.1">
        <property type="protein sequence ID" value="ENSCGRP00001003704.1"/>
        <property type="gene ID" value="ENSCGRG00001004553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764761"/>
    <dbReference type="KEGG" id="cge:100764761"/>
    <dbReference type="CTD" id="403314"/>
    <dbReference type="GeneTree" id="ENSGT00390000014243"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038953">
        <property type="entry name" value="APOBEC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35672">
        <property type="entry name" value="C-U-EDITING ENZYME APOBEC-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35672:SF1">
        <property type="entry name" value="C-U-EDITING ENZYME APOBEC-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18778">
        <property type="entry name" value="NAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035301593.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39874" checksum="BAC2CC635F906C60" modified="2022-01-19" version="1">MEPLYEEYLTDDGTIVKPYFWLSFSLDCTNCPYHIRTGEEARVPYTEFQRIFGFPWSTYPQIKHLTFYELRSSSWNLIQKGHASNCTGNLSHPESMLFEKNGYLDSVISYNSNIRHIILYSNHSPCNEASHYCISKMYTFLMMYPDITLNIFFSQLYHTENQFPTSARNREALRSLASLWPQVTLNPISGDIWHCILENFVSCVPGVLQPFTSGRILVDRYNAYEINSITGVKPYFINVLLRQERERQSRKVWATLENYPLNNADPGQAKLSQGPSTSVVSMLVPYRELPPILVSQNPQKPRNVVRHLNMPQLSSSKAKDLRESLSGKPMTASHRWVWRQQRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QFV5</accession>
    <name>A0A8C2QFV5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Two pore channel protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Two pore calcium channel protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 31" type="primary">Tpcn2</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">(Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:29673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:34965"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homodimer. Interacts with LRRK2. Interacts with HAX1. Interacts with MTOR; the interaction is required for TPCN2 ATP sensitivity. Found in a complex with LSM12, TPCN1 and TPCN2. Interacts with LSM12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Melanosome membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027264592.1">
        <property type="nucleotide sequence ID" value="XM_027408791.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035293166.1">
        <property type="nucleotide sequence ID" value="XM_035437275.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035293167.1">
        <property type="nucleotide sequence ID" value="XM_035437276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QFV5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012712.1">
        <property type="protein sequence ID" value="ENSCGRP00001008583.1"/>
        <property type="gene ID" value="ENSCGRG00001010845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755221"/>
    <dbReference type="KEGG" id="cge:100755221"/>
    <dbReference type="CTD" id="219931"/>
    <dbReference type="GeneTree" id="ENSGT00940000159763"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036020">
        <property type="term" value="C:endolysosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097682">
        <property type="term" value="F:intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090117">
        <property type="term" value="P:endosome to lysosome transport of low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048086">
        <property type="term" value="P:negative regulation of developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019065">
        <property type="term" value="P:receptor-mediated endocytosis of virus by host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006939">
        <property type="term" value="P:smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000104">
        <property type="entry name" value="Two pore calcium channel protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000073">
        <property type="entry name" value="Two pore segment channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028798">
        <property type="entry name" value="TPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46768">
        <property type="entry name" value="TWO PORE CALCIUM CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46768:SF1">
        <property type="entry name" value="TWO PORE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="27">
        <location>
            <begin position="74"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="27">
        <location>
            <begin position="417"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00059675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00065530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00072840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027264592.1"/>
        </source>
    </evidence>
    <sequence length="735" mass="84325" checksum="7B9A91BFE0E35CD5" modified="2022-01-19" version="1">MAAEAQPLLGRDRGGGQARSGAASSQELCIDQAVVFIEDAINYRSIYHRMDAGSLWLYRWYYSNLYQRVLSFTIFLILALAFVEFPSSFTRTADVRYRSQPWEPPCGLTETIEAFCLLVFLVDFSVKSYLVGQPQLQENLWLLSYFVVLVVSVVDWIISVSLTCEEPLRVRRSLRPFFLMQNSSMMKKTLKCLRWSLPEMASVGLLLTIHLCLFTIIGMLIFSSDEKDEAQNQERLAYFRDLPEALTSLFILLTTSNNPDVMIPAYSQNRAYALFFIIFTLIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGARAAYEVLASTAGLAGATPEAVGVNPENFLRVLQKTQLDKIHKQAIMQKVHSYGGRPLLADEFQKLFDEVDKGVIKEVPPMPQYQSPFLQSAQFLFSNQYFDYLGNLIALGNFLSICVFLVLDSKLLPEERDDFVLEILDYVFVLYYLLEMLLKLFALGLRGYLFYCGNVFDGFLTIVLLVLEISTLVIYRLPNSVWKPKQFGSLSLWDMTRLVNTLIVFRFLRVIPNVKPIAMVTSTILGLVQNFKSFGGILVVTYYVFAIIGINLFQGIIVPPGNSSLAPDNSSAVCGSFEQLDYWSNNFDDFAAALITLWNVMVVNNWQVLLEAYQRYSGPWSMVYFVLWWLVSSVIWINLFLALLLENFVHRWDPGSYKQLLVGNQKINYQMSVELMFRDILEEPKEEELIEKLHKHPHLQLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QGJ8</accession>
    <name>A0A8C2QGJ8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Keratin 15</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Keratin, type I cytoskeletal 15 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Krt15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511377.1">
        <property type="nucleotide sequence ID" value="XM_003511329.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283976.1">
        <property type="nucleotide sequence ID" value="XM_027428175.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QGJ8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014879.1">
        <property type="protein sequence ID" value="ENSCGRP00001010655.1"/>
        <property type="gene ID" value="ENSCGRG00001012486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759259"/>
    <dbReference type="KEGG" id="cge:100759259"/>
    <dbReference type="CTD" id="3866"/>
    <dbReference type="GeneTree" id="ENSGT00940000154403"/>
    <dbReference type="OMA" id="EARYCAQ"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF164">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="102"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027283976.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="49476" checksum="8DF4AD74DF7889A9" modified="2022-01-19" version="1">MATTFLQTSSTFGGGSTRGGSLRAGGGGFGGGSLYGGGGSRSISASSARFVSSGAGGGYGGGMSCGFGGGAGSGFGGAFGGGFGGGFGDFGGGDGGLLSGNEKITMQNLNDRLASYLDKVRALEQANTELEVKIRDWYQKQSPASPERDYSHYFKTMEEIRDKILAATIDNSRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLARTDLEMQIEHLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRMLAEMREQYEAIAEKNRRDAEAWFFSKTEELNKEVASNTEMIQSSKTEITDLRRTMQGLEIELQSQLSMKAGLENSLAEVECRYATQLQQIQGLISSLESQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYRNLLEGQDAKMAGIGVREASLGGGSGGGSSSSNFHISVEESVDGKVVSSRKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QJN6</accession>
    <name>A0A8C2QJN6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Tyrosine-protein kinase receptor Tie-1</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34 37" type="primary">Tie1</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="36" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
            <tissue evidence="37">Liver</tissue>
        </source>
    </reference>
    <reference evidence="34" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Heterodimer with TEK/TIE2. Interacts with SVEP1 (via C-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003502701.1">
        <property type="nucleotide sequence ID" value="XM_003502653.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254858.1">
        <property type="nucleotide sequence ID" value="XM_027399057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QJN6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021418.1">
        <property type="protein sequence ID" value="ENSCGRP00001017174.1"/>
        <property type="gene ID" value="ENSCGRG00001017265.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768521"/>
    <dbReference type="KEGG" id="cge:100768521"/>
    <dbReference type="CTD" id="7075"/>
    <dbReference type="GeneTree" id="ENSGT00940000157693"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003180">
        <property type="term" value="P:aortic valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060854">
        <property type="term" value="P:branching involved in lymph vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060836">
        <property type="term" value="P:lymphatic endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045026">
        <property type="term" value="P:plasma membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001936">
        <property type="term" value="P:regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901201">
        <property type="term" value="P:regulation of extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048771">
        <property type="term" value="P:tissue remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05089">
        <property type="entry name" value="PTKc_Tie1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000113">
        <property type="entry name" value="Putative tyrosine-protein kinase receptor Tie-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000123">
        <property type="entry name" value="Tyrosine-protein kinase receptor Tie-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000591">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000597">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000583">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000758">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF341">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR TIE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="14 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 26" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13 37" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19 37" id="KW-0675">Receptor</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 29" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679290" description="Tyrosine-protein kinase receptor Tie-1" evidence="29">
        <location>
            <begin position="23"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="760"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="31">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="31">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="32">
        <location>
            <begin position="352"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="33">
        <location>
            <begin position="450"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="33">
        <location>
            <begin position="546"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="33">
        <location>
            <begin position="645"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="838"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00056816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00065364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00072428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="XP_027254858.1"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124778" checksum="FC7D50843AE76B1A" modified="2022-01-19" version="1">MVWWGSPFLLPVLFLASHVGAAVDLTLLANLRITDPQHFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTFPPGQPLNLARNGSHQVTLRGFSKPSDLVGVFSCVGGASTRRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSARVHKAKQTDVIWKNNGSYFHTLDWHEAHDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCGKDCPGCLHGGVCHDYDGECVCPPGFTGTRCEQACREGRFGQRCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWKGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNVATELEFNLGTRPRINCAAAGNPFPVRGSMELRKPDGTMLLSTKAIVEPDKTTAEFEVPGLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPIPLTAPRLLAKQSRQLVVSPLVSFGGDGPISSVRLHYRPQDSMIAWSAIVVDPSENVTLMNLKPKTGYSVCVQLSRPGEGGEGPWGPPTLMTTDCPEPLLQPWLEGWHVEGPDRLRVSWSLPSVPLFGDGFLLRLWDGARGQERRENISSPQARTALLTGLTPGTHYQLDVRLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWQHPEAPSGPISKYIVEIQVAGGSGDPKWMDVDRPEETSTIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGLQSEGPVQESRAAEEGLDQQLVLAVVGSISATCLTILAALLALVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EVK4</accession>
    <name>A0A9J7EVK4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Bmp2k</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_027243470.1">
        <property type="nucleotide sequence ID" value="XM_027387669.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EVK4"/>
    <dbReference type="GeneID" id="100769791"/>
    <dbReference type="KEGG" id="cge:100769791"/>
    <dbReference type="CTD" id="55589"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000072">
        <property type="entry name" value="AP2 associated kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051744">
        <property type="entry name" value="AP2_assoc_SerThr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028182">
        <property type="entry name" value="BMP2K_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907:SF4">
        <property type="entry name" value="BMP-2-INDUCIBLE PROTEIN KINASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15282">
        <property type="entry name" value="BMP2K_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="627"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="867"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="926"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1095"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="932"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027243470.1"/>
        </source>
    </evidence>
    <sequence length="1119" mass="125129" checksum="7AB4A25F3E7AE843" modified="2023-06-28" version="1">MKKFSRMPKSEGSGGGAAAGRVVRVSVGRYQVTLEESLAEGGFSTVFLVRSHGGIRFALKRMYVNNTSDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFSESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGRPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGSFTIPDSSRYSHNIHCLIRFMLEPDPELRPDIFQVSYFAFKFAKKDCSVSNINNSSLPSTLPEPMTASEAAARKSQMKARITDTIGPTETSIAPRQRPKANSATATSSVLTIQSSATPVKVPAPGEFSNHKPKGILRPGNGSEVLVGQGPPQQPPQQHRVLQQLQQGDWRLQQLHMHRDPHQQQHQHQQHQHQQQQQLQQQQQQQQLLQNAYLQQYQHAMRQQQILQQQFLMHSVYQPQPPTSQYPTMMQQYHQAFLQQQMLAHRQQPQHHQQPQQQASPEYLTSPQEFSPALVSYTSSLPAQLGTIVDPSFGANRLVAEKEAVAHFTNEKAISHPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEESAPSDKNVDPPSAPHNHPPEDPFGSVPFISHSGSPEKKTERSPNQKNITANPTKNGSASPLCKDQRAIKKTPENPAVRGQVQKGHDESESDFESDPPSPKSSEEEQEDEDAQGEHGDFNDDDTEPENLGHRPLLMDSEDEEEEDKHSSDSEYEQAKAKYETGGGRSPAPDPALLSPACSPTDALTPGQEFDVFGAVPFFAVQAPQQQHRGNGKNLSQQTFPEQEDFDVFTRAPFNKKVNNVQDWPTAGPDTRPLPARPRSVDMFGSTPFQPFSTSASRSESREDVFGLVPFEEITGSQQQKVKQRSLQKLTSRQRRTKQDVSKSNGKRHHGTPTSSKKPLKPPYRTPERARRHKKVGRRDSQSSSEFLTISDSKENISVALTDGRDRGSGLQPEESLLDPFGAKPFHPPDLSWHQSHQGLSDICVDHNTILPGRPRQNSVHGSFHSADALRMDDFGAVPFTELVTPRESQQSQPVELDPFGAAPFPSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EYW3</accession>
    <name>A0A9J7EYW3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC113832540</name>
        <name evidence="10" type="synonym">LOC113830756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9 10">17A/GY</strain>
            <tissue evidence="9 10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027245033.1">
        <property type="nucleotide sequence ID" value="XM_027389232.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027290267.1">
        <property type="nucleotide sequence ID" value="XM_027434466.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EYW3"/>
    <dbReference type="GeneID" id="113832540"/>
    <dbReference type="KEGG" id="cge:113830756"/>
    <dbReference type="KEGG" id="cge:113832540"/>
    <dbReference type="OrthoDB" id="10054543at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000011">
        <property type="entry name" value="28S ribosomal protein S18a, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF66">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027245033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027290267.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22058" checksum="8C16A6E9D1036777" modified="2023-06-28" version="1">MAALRALVSGCGRQLQGFLAGPAATGWLRLPARGLREVVEIQEGKTTVIEGRITETPKATPNPPNPSGQCPICRWNLKHKYNYEDVLLLSQFIRPHGGVLPRNVTGLCLEEHRKIEECVKMAHRAGLFPNHRPRLPEGSLPRNKPKLNRYLTRWAPSSVKPIYKKGHRWNKVGMAVGSPLLKDNVCYSRRPLKLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F144</accession>
    <name>A0A9J7F144_CRIGR</name>
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        <submittedName>
            <fullName evidence="7">Ankyrin repeat domain-containing protein 26-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100772381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027247684.1">
        <property type="nucleotide sequence ID" value="XM_027391883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F144"/>
    <dbReference type="GeneID" id="100772381"/>
    <dbReference type="KEGG" id="cge:100772381"/>
    <dbReference type="OrthoDB" id="9634956at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040118">
        <property type="entry name" value="C144A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039497">
        <property type="entry name" value="CC144C-like_CC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021885">
        <property type="entry name" value="DUF3496"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22245">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22245:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14915">
        <property type="entry name" value="CCDC144C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12001">
        <property type="entry name" value="DUF3496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC144C-like coiled-coil" evidence="5">
        <location>
            <begin position="105"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3496" evidence="4">
        <location>
            <begin position="385"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="72"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027247684.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="71313" checksum="3FD2238B3AB14E10" modified="2023-06-28" version="1">MEDFDDLTQSSEISSFGKFPCPNYEAVLKLIEHLSLECKDSDSLLKIQDTIHSYKRLIQFKSSHCKALEGKLGIMENEVTGLHKKLSEAEHEKIKQEQELYNLRFALKQEEEKRKNADWVYEKIKEQLREKEAQYNKEVKVKQKLEIRVRELDLELKTVINNLNKATEERNGIERQLLQEQNVRILQDEILANQLHKQKELKMAQEKISSQFQEALDQHQQEPAECIKKMQDYIQKLGLENCKLKATARKQAEKIEQLKKNLVSEILNDDLTAKLETASSKCLHLHKENQLLQQELLSMKTIQKKCEKLKKHKRKLEQEIVNLKVYMEKNMIECGQMEQYKWEIEEKTKQALAEKLKQVNLFLQTQAAYEDKLEKLRHEQNASVRTEMELRIRDLESEFCKMKSQVDCNQIEMENYKQLYLEEVKIRKSLSNKLSITDERLAKVKTKLLQERKQNRTSQYSTIDTRSVLESTCQRDLSNRFFIPRSFSGENVMVPTSNLWHSIETTENCKTKYTAVYICRRIRGGTDGFELPTAAPGDVLVAFEALCVRDLYFELGKPSAKPRCPPLSQVDKKGRRAASASSAGLMELRPSQSTASSPALSPVSQSVTLTYPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F3X0</accession>
    <name>A0A9J7F3X0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">F-box/LRR-repeat protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">Fbxl3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14">17A/GY</strain>
            <tissue evidence="13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027249786.1">
        <property type="nucleotide sequence ID" value="XM_027393985.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249787.1">
        <property type="nucleotide sequence ID" value="XM_027393986.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312459.1">
        <property type="nucleotide sequence ID" value="XM_035456568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F3X0"/>
    <dbReference type="GeneID" id="100761851"/>
    <dbReference type="KEGG" id="cge:100761851"/>
    <dbReference type="CTD" id="26224"/>
    <dbReference type="OMA" id="RWNQAFH"/>
    <dbReference type="OrthoDB" id="9974792at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22178">
        <property type="entry name" value="F-box_FBXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23957">
        <property type="entry name" value="FBXL3_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000005">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000010">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224">
        <property type="entry name" value="ES1 PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF18">
        <property type="entry name" value="F-BOX AND LEUCINE RICH REPEAT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027249786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027249787.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48671" checksum="76651E6590E1FFB5" modified="2023-06-28" version="1">MKRGGRDSDLDSPEEGTAEKRKKLRTAHECSQPCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIKHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F6S1</accession>
    <name>A0A9J7F6S1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho guanine nucleotide exchange factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Guanine nucleotide exchange factor H1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">Arhgef2</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
            <tissue evidence="35">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="29">Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3. Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-885. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1. Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II). Interacts with DYNLT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007641732.1">
        <property type="nucleotide sequence ID" value="XM_007643542.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248941.1">
        <property type="nucleotide sequence ID" value="XM_027393140.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F6S1"/>
    <dbReference type="GeneID" id="100758849"/>
    <dbReference type="KEGG" id="cge:100758849"/>
    <dbReference type="CTD" id="9181"/>
    <dbReference type="OrthoDB" id="28045at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20877">
        <property type="entry name" value="C1_ARHGEF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13393">
        <property type="entry name" value="PH_ARHGEF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000004">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000021">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000032">
        <property type="entry name" value="rho guanine nucleotide exchange factor 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037806">
        <property type="entry name" value="ARHGEF2_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF20">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="22" id="KW-0007">Acetylation</keyword>
    <keyword evidence="26" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="21" id="KW-0965">Cell junction</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="27" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="25" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="17" id="KW-0221">Differentiation</keyword>
    <keyword evidence="23" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="19" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-0498">Mitosis</keyword>
    <keyword evidence="20" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0796">Tight junction</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="33">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="32">
        <location>
            <begin position="281"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="518"/>
            <end position="617"/>
        </location>
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        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
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        <location>
            <begin position="868"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="30">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
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            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031760"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062640"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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        <source>
            <dbReference type="RefSeq" id="XP_027248941.1"/>
        </source>
    </evidence>
    <sequence length="992" mass="112228" checksum="92D11DD2C3E6DFA0" modified="2023-06-28" version="1">MLSKAVSMSGINFFLDCSDPEGNSFRSSATDLRKCGSQLEGDSGTWAGSSLRRTFSFFWGMTGKAKAREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGARRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEGAEVIYNELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQVEPGVVQGMFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHNKALKLYKELYARDKRFQQFIRKVTRSAVLKRHGVQECILLVTQRITKYPVLINRILQHSHGIEEESQDLTTALGLVKELLSNVDQDVHELEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDQKYIFPALDKPSVISLQNLIVRDIANQAKGMFLISAGPPEMYEVHTASRDDRSTWIRVIQQSVRVCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLQEKVGLFAEMTHFQAEEDGVSGMPLPALPRGLFRSESLESPRGERLLRDAIREVEGLKDLLVGPGADLLLTPREPALPLESDSGNTSPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEETLQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERWEKDELRRCRRLAEERAAEASNLEVRLRESEQARAVLEREAEEARRQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDMPVTVRSLHRPFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGETTASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F9D5</accession>
    <name>A0A9J7F9D5_CRIGR</name>
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        <submittedName>
            <fullName evidence="6">Ankyrin repeat and LEM domain-containing protein 1 isoform X5</fullName>
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    <gene>
        <name evidence="6" type="primary">Ankle1</name>
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    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="100753605"/>
    <dbReference type="CTD" id="126549"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GIY-YIG_COG3680_Meta"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034998">
        <property type="entry name" value="ANKLE1"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="3">
        <location>
            <begin position="431"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027250615.2"/>
        </source>
    </evidence>
    <sequence length="595" mass="64482" checksum="1443C814B89546B3" modified="2023-06-28" version="1">MLCRLLFTLQNPPQMSFPSGSPPETRNMQGVARVEPEAEPESRGAGLRVRRGGRARIRTAERGDMATATGRARQLQAALRAEEPRAVEELLRLGADPSLVLEEGAAAVHLAARAYSPRALRCLRILLRRGADPNARSAEALTPVHVAAAWGCRGALELLLSGGGDPTLRDQDGLRPLDWALQQRHHNCARVLRELDGPPGAREPAAPADLEHAMCRGRVFAGSPGLTTPPHVSLASEQHMSPAKLAAAGEVPVKPLELCSSEATRSPDCSSDTSFVTALEDSPQPQHPAGTPGSAADPWLSRGAKAAGDGALSCQLQALTLTREATNVPSQPGDRDPGALHPQGPVSPMSDLQLLQALRALGHSPGPVTPFTRGYYLRRLQEAQASLGHSPELAEALKTGHVPDCQADEAALAQHFQRLDPAKRWREGVTKSSFTYLLLDPRQTQGLPARASSLTLAECLQSFVRAIFYVGKGTRARPDAHLWEALGYREWPGKKACPKIQRILAIWDSGRGVISLHCFQHAVAVEAYTREACLLDALGIQTLTNQKQGHYYGEVAYWPPTRRRRLGVYLLHRALQVFLAEGERELRPQDIQARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FCE7</accession>
    <name>A0A9J7FCE7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hexosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Chsy3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Golgi apparatus</location>
            <location evidence="3 14">Golgi stack membrane</location>
            <topology evidence="3 14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_027256747.1">
        <property type="nucleotide sequence ID" value="XM_027400946.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FCE7"/>
    <dbReference type="GeneID" id="100767985"/>
    <dbReference type="KEGG" id="cge:100767985"/>
    <dbReference type="CTD" id="337876"/>
    <dbReference type="OrthoDB" id="431432at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050510">
        <property type="term" value="F:N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000060">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000004">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF40">
        <property type="entry name" value="CHONDROITIN SULFATE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="53"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027256747.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="99867" checksum="35A31CAA839804E0" modified="2023-06-28" version="1">MAVRSRRPWVSVALGLVLGFTAASWLIAPRVAELSERRRHGSSLCSYYGRLATGPRAGAQQPLPQPQSQPRLEQSPPPASQELQGPQRPEAAPGGPSFRSSPGQQPASLPQRRRGHKPEGATALPGAPAAKGVPEEEDGGAAGPRKGGRPGTSHNGSGDGGAAAPSSGPGDFLYVGVMTAQKYLGSRALAAQRTWARFIPGRVEFFSSQQSPSAALGQPPPPLPVIALPGVDDSYPPQKKSFMMIKYMHDHYLDKYEWFMRADDDVYIKGDKLEEFLRSLNSSKPLYLGQTGLGNTEELGKLGLEPGENFCMGGPGMIFSREVLRRMVPHIGECLREMYTTHEDVEVGRCVRRFGGTQCVWSYEMQQLFHENYEHNRKGYIQDLHNSKIHAAITLHPNKRPAYQYRLHNYMLSRKISELRYRTIQLHRESALMSKLSNSEVSKEDQQLGVMPSFNHFQPRERNDVIEWEFLTGKLLYSAAENQPPRQSINSILRTALDDTVLQVMEMINENAKSRGRLIDFKEIQYGYRRVDPMHGVEYILDLLLLYKRHKGRKLTVPVRRHAYLQQLFSKPFFREMEELDVNSLVESINSGTQSFSFISNSLKILSSLQEAKEIGWHKEKKVHILVPLTGRYDIFLRFMENFESTCLIPKQNVKLVIILFSGDSGQESNKHIELIHEYQNRYPNAEMMLIPMKGEFSRGLGLEMAASQFDNDTLLLFCDVDLIFRGDFLQRCRDNTIQGQQVYFPIIFSQYDPKVTHMGNPPPEDDFVFSKETGFWRDYGYGITCIYKSDLLGAGGFDTSIQGWGLEDVDLYNKVILAGLQPFRSQEVGVVHIFHPVHCDPNLDPKQYKMCLGSKASTFASTMQLAELWLEKHLGIRDNRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FER3</accession>
    <name>A0A9J7FER3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cannabinoid receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Cnr2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255511.1">
        <property type="nucleotide sequence ID" value="XM_027399710.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027294135.1">
        <property type="nucleotide sequence ID" value="XM_027438334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FER3"/>
    <dbReference type="GeneID" id="100752745"/>
    <dbReference type="KEGG" id="cge:100752745"/>
    <dbReference type="CTD" id="1269"/>
    <dbReference type="OMA" id="AFDRYIC"/>
    <dbReference type="OrthoDB" id="5966748at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004949">
        <property type="term" value="F:cannabinoid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15341">
        <property type="entry name" value="7tmA_CB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000072">
        <property type="entry name" value="Cannabinoid receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001551">
        <property type="entry name" value="Canbinoid_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002230">
        <property type="entry name" value="Cnbnoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00523">
        <property type="entry name" value="CANABINOID2R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00362">
        <property type="entry name" value="CANNABINOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="50"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027255511.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39642" checksum="129AAC7D0BE17D7B" modified="2023-06-28" version="1">MERCWEMGVTNGSESGLEFNPMKDYMILSDAQKIAVAVLCTLLGLLSALENLVVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVLSAFISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFAGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDRVKEVFAFCSMLCLANSMVNPIIYALRSGEIRSAAQHCLVSWKKYLQGLGPEGKEEAPRSSITETEADVRTTPDPGSRSPGCSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FGI1</accession>
    <name>A0A9J7FGI1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 76 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Cep76</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with CCP110 and CEP97.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP76 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258490.1">
        <property type="nucleotide sequence ID" value="XM_027402689.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313352.1">
        <property type="nucleotide sequence ID" value="XM_035457461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FGI1"/>
    <dbReference type="GeneID" id="100760887"/>
    <dbReference type="KEGG" id="cge:100760887"/>
    <dbReference type="CTD" id="79959"/>
    <dbReference type="OrthoDB" id="5527234at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000003">
        <property type="entry name" value="Centrosomal protein of 76 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028926">
        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056289">
        <property type="entry name" value="CEP76_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15627">
        <property type="entry name" value="CEP76-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24654">
        <property type="entry name" value="CEP76_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP76 N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76 C2" evidence="8">
        <location>
            <begin position="99"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="11">
        <location>
            <begin position="360"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="9">
        <location>
            <begin position="517"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027258490.1"/>
        </source>
    </evidence>
    <sequence length="658" mass="74247" checksum="005F7F8D9AEF7B79" modified="2023-06-28" version="1">MSLPPEKASELKQLIHQQLSKMDVHGRIREILAETIREELAPDQQHLSTEDLIKALRRRGIIDDVMKELNFVTDSVDQELPSPKQIVAFDKQSTLKKTNIDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQVCSTFTLCLHYRNQRFRSKPVPCACEPDFHDGFLLEVHRESSGDGTRMADSTTMLSISDPIHMVLIKIDIFGETTLVASYFLEWRSVLGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLNQTLSQEVVNTQLALERQKTAEKERLFLVYAKQWWREYLQIRPSHNSRLVKIFAQDENGINRPVCSYVKPLRAGRLLDTPRQAARFVNVLGYERAPVIGGGGKQEQWCTLLAFLCRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGAPHSWVMTCGTDGTIMFWESLTGHRYIHKPTNPDGSPLAEQPKPLYPYRTIGCVFNHQMFLGNCQPSDAVETCIFDLNDESKWKPMSEDAIKSVCAPGATTSLPPFPPLCASTIDASVTSNEIEMQLRLLVSEHRKDLGLTTVWEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFVYRNARRAFATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACKYRSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FH10</accession>
    <name>A0A9J7FH10_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Granzyme K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Gzmk</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027257245.1">
        <property type="nucleotide sequence ID" value="XM_027401444.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FH10"/>
    <dbReference type="GeneID" id="100774132"/>
    <dbReference type="KEGG" id="cge:100774132"/>
    <dbReference type="CTD" id="3003"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000010">
        <property type="entry name" value="Kallikrein related peptidase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF52">
        <property type="entry name" value="GRANZYME K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039908868" evidence="7">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="26"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027257245.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="28924" checksum="5D5790ADD373C7F0" modified="2023-06-28" version="1">MRLSSFALFFLTAGLYLSSKCFCTEIIGGSEVQPHSRPFMASIQYHGNHICGGVLIHPQWVLTAAHCYSWFPRGHSPTVVLGAHSLSNNEPAKQTIKITRFIPFSRSPSGFTSHDIMLIKLHTAAELNKHVQLLQVRSKNYVRDGTKCQVTGWGATNPDLLKPSDTLQEVTVSIIGRKHCNSQKYYNRNPVITRDMICAGDAKGRKDSCQGDSGGPLICKGVFHAIVSGGYKCSIANKPGIYTLLTKKYQSWIKSKLAPSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FHA3</accession>
    <name>A0A9J7FHA3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 11">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Msh3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027257546.1">
        <property type="nucleotide sequence ID" value="XM_027401745.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FHA3"/>
    <dbReference type="GeneID" id="100762943"/>
    <dbReference type="CTD" id="4437"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016447">
        <property type="term" value="P:somatic recombination of immunoglobulin gene segments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000917">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="14">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027257546.1"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123080" checksum="9637A0F1ECB0C700" modified="2023-06-28" version="1">MPRTKSASSGHSSAAQAPRRQAVLSRFFQSSGSLRSTASPTEPAEKVTKSYSRRRSLGSEGPVKKKAKEVPEKEEENTSVISGNPEPKKCRRPRIVLKSLEKLKEFCCESALPQNRVQTEPLQERFAVLPKCTDFEDITLQRAKNAVSSEDSKSQADQKDSQLGPCPENFQKASDCKPFNKRSKSVYTPLELQYIDVKQKHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQMETAALKAIGDNKSSVFSRKLTALYTKSTLIGEDVNPLIRLDDSVNIDEVMTETSTSYLLCIYEEKENSKDKKKGNISIGIVGVQPATGEVVYDCFQDSASRLELETRISSLQPVELLLPSHLSELTEMLIHRATAVSIRDDRIRVERMDNTYFEYSHAFQAVTEFYAREVVDSKGSQNFSGIINLEKPVICSLAAIIRYLKEFNLEKILSKPENFKQLSSGMEFMRINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLRDINARLDAISDVLHSESSVFEQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKSLSHLKSELQALIPAVSSLVQSDLLRTLILETPALLSPVEHYLKILNEQAAKVGDKTELFKDLTDFPLIKKRKDEIQEVTQSIQMHLQELRKMLNRPSLQYVTVSGQEFMIEIKNSAVSCIPADWVKVGSTKAVSRFHPPFIVENYRRLHQLRDQLVLDCSAEWLDFLENFGEHYHTLCKAVNHLATVDCIFSLAKVAKQGNYCRPTLQEEKKIVIKNGRHPMIDVLLGEQDQFVPNSTSLSQDSERVMIITGPNMGGKSSYIKQVALIAIMAQIGSYVPAEEATIGIVDAIFTRMGAADNIYKGRSTFMEELTDTAEIIRKATPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVDEDESKQESGNMEQVPDSVTFLYQITRGIASRSYGLNVAKLADVPGEILKKAAHKSKELEGLVNLRRKRLKYFTDLWTTHDVKDLHTCIEDLGTEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FHX3</accession>
    <name>A0A9J7FHX3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myotubularin-related protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive phosphatidylinositol 3-phosphatase 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Mtmr12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with lipid phosphatase MTM1. Heterodimer with lipid phosphatase MTMR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027257055.1">
        <property type="nucleotide sequence ID" value="XM_027401254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FHX3"/>
    <dbReference type="GeneID" id="100750401"/>
    <dbReference type="KEGG" id="cge:100750401"/>
    <dbReference type="CTD" id="54545"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14594">
        <property type="entry name" value="PTP-MTMR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000188">
        <property type="entry name" value="Myotubularin related protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022587">
        <property type="entry name" value="MTMR12-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030576">
        <property type="entry name" value="MTMR12_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF37">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12578">
        <property type="entry name" value="3-PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="10">
        <location>
            <begin position="205"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027257055.1"/>
        </source>
    </evidence>
    <sequence length="765" mass="88054" checksum="B6280063BDF53BED" modified="2023-06-28" version="1">MLGKGGVGGGGGTKAPKPSFVSYVRPEEIHSNEKEVTEKEVTLRLLPGEQLLCEASTVLKYVQEDSCQRGVYGRLVCTDFKIAFLGDDNSALDNGGETQFKNKIVGENDVPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYAAAVHSTATDPRNHTIMFDTPKDWSWELERTKGSVKYKTVRVNEGYRICDRLPAYFVVPTPLLEEDVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGALQIQKSFLDGIYKTIHRPPYEIVKTEDLSSNFLSLQEIQNAYCKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECLEAQNMNVLLLEENASDLCCLLSSLVQVMMDPHCRTRTGFQSLIQKEWVMGCHSFLDRCNHLRQSDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETFLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRESLDTQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDKGQRRGSRFKVRCECLNLPQHQLLHPMHHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDEFQDNSREFYDNWHSKPIDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGRVATMSKLLEMVEEVQSLQEKINAKHHRQEAVHTQAPCLLRNSARLSSLFPFALLQRHSSKPVLPTSGWKALGGEDDLAKQEDEFVDLGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FII2</accession>
    <name>A0A9J7FII2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Interferon-induced very large GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100755428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027260767.2">
        <property type="nucleotide sequence ID" value="XM_027404966.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100755428"/>
    <dbReference type="KEGG" id="cge:100755428"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058641">
        <property type="entry name" value="GVIN1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057365">
        <property type="entry name" value="URGCP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796:SF6">
        <property type="entry name" value="INTERFERON-INDUCED VERY LARGE GTPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796">
        <property type="entry name" value="URG4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25496">
        <property type="entry name" value="URGCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25974">
        <property type="entry name" value="URGCP_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25683">
        <property type="entry name" value="URGCP_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VLIG-type G" evidence="9">
        <location>
            <begin position="1486"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1628"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1850"/>
            <end position="1877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027260767.2"/>
        </source>
    </evidence>
    <sequence length="2428" mass="279346" checksum="4834E67E2BEF15E4" modified="2023-06-28" version="1">MERKTGILDESQSRSRRQQNLQEMVKEVGLSADYWLPKLQEDLGVTCAQALQHIEEKDLQKLKSQTQYTWEKKALEKLLDLSQINSGAEFQETPGGVIKNRQKQAEQALQELRTLQSQGKHRQEEAVRRKEVELRQAMEIPEECWPGPEVPLEDITETMERHLSHIEQTLANSENLSHRDLLRFTSGGLALQGIYKTSHQKDLVARREELLRVPQEFLLFGPEQGKQMETKEFTSSKEESLFTETVEKLGFRLTLSAKGGGWGFSSEGGMDKVKHSESKDAHQSHSKHSYFCSSMFSYNPLASFHFRTDQLQLSKGALKELKIIEEQLEHTDGPDRFLVVRNRTENFFNRFGSHANQGSLHLGGIYCWKAISEGFRSDQLDCVKQQTAEALNTYIRGSYSGFGIKVGGEMTTSESHLVRSYKNSTNQQCQIKVKLSVAHIGGPPEANGVVQWTTGLLASNKTWSVIDRELQLVPIWDIILSNHRSSFKDPFLLASCLADNYSALTGLDAHIQAGEEVLSSIKEAGYFLDDVKSWEVSDPEEQLKKLMVFMQALAHKTKGYEIWINSCLTNLDLQNFLISTVNFCKTSSIKNTQFIKSQIHGLLEPHVYKVKNFPQLKSIMQWIYQTESEEPQVKITELSEFLKNLKEIQKFLTEANIKSESPETVEEAQRKATCDVTTALSSFLNYLRETEQPDMQLLLLSIAAGAGYQLESGIFQPLLGCAELTFLLDEIQTVQNTYQELKTLYIDRAQAFLVLKVLMTTVGVSAISPEEKAQRLALTRQHMEHLLSTKVKHILTNFGTDDWETLENNLRLLIDGKYEDSVSSLQMDEVKKQLQSLLNQNKETYEQQDDDNNEKEVIEKGPFLDLLQRLGLEHHYPKGMSRADFHLIYKTSVYNTQPGSEQELPFYFLQKLLMLDCGFRYLFFKNAGNAETKDSVGPSNQENEVIDPYEELFDDSEEVTNSVGTDFPSQIHPMDIQMAIYHCADDLARQYILSKLSICQFALPLVVPNPNTSQLEFSLWSLRQVRRSWQEAGKSPQDKSYSHKKQQMCCVSTPIVSFIRVGNGLSASKSQIMNSLLSKHKHDVFFHRHCRGSSKHCLLMEGVTEICWFCPGSQGEDIFDKCVAFTNLHGDAKEHRQQLSFLQDVSSLIVILMSASDNNKENQTLVRQLWQSSKPLVCLIDDKEKVMTNNSGRKVRIGIRNRNEAELTEELMTTIKNLLEISGTVLSIEDCSQVARKQGFKIDEDQRKLKEAKEKAQKNMELLKKSKLSQVKENLLPLQGQLWHLWCKKDKELYHLQEKGHRSIEQHKSDIETEKQKIRWQQFKKAFPLNDLMQSVLKILKEDSENDLKLYFLYWLSVILEYLTMEHLEVLHEKQQFLWSQVQAEKERAEKSSSLTNWQKQIEGIATEIFNCTFGIEHILREVGQIYEALEETSSTRDRLFLCLPQIAADLMIAGVPIELMDGDASYVPLKWIAAVFDKISEKVGDKRLFVLSVLGLQSSGKSTLLNALFGLEFTVSAGRCTKGAYMQLLEVDKKFTGELGFDFMLVVDTEGLRAPELNNKSQNWDNELATFVTGLGNLTLINIFGENPSEMQDILQIVVQAFLRMKQVKISPSCIFVHQNVGEVTAKDQTMEGRRRLEQRLDEMTALAAEQEECSNITRFSDVIKFDVNSHVYYFAHLWDGNPPMAPPNPRYSHNVQELKNGILRIARQESGGRIMKISDVKFRVQDLWNALVTENFIFSFRNTQEVIAMSKLETMYNQWTWELRSYVLDLQNQLNNQIQNGKILTLTTNTLEGPLNKKYETIKQDFDKYFEEDPDSETLVQWKANFEHKLLILKDTLISDTRRKGNELISLKKSQDTLDNQKSQYENELLEKSRKLALSLKGKELSDEELREKFNQVWKNWIYNVSSTAPPITEPNIDGDAESIILGYFTKDKNIAERLRRNDREIFCVNYDKHVQMKKKYHIFTKSLESCHKESINETTNYIYLRFNETIETIWKQKRDYNQNDFHKILRIIEYKMKSVSPEEDYTFTRDYTIDLSLFLFQKASKSFKEMHKAFKIANDPVTYLESKKDDFFLSFKISCQGATSITSFVDFLWLKLTPAISATIWGKMGPKVAGDMRSTCPAFSGNRANLEKHILISLAEEENFDKYWQYIHQPQSFFRDYISEHIRRYCSEKESEKVKTFLKISLGDIKNAILTAIHKTTEVANNESSTASGWLDLFCDHLGSNLIFPRKDLISIEHQEIKDTEFLKEAMSAALDPAMRKVEEDCSRRPIDEMVPNIEKILSEHLCGCWNQCPFCKAICTNTIPQHEGDHSVPFHRPQSVRGGGWYKTNDFDISCCSTSVSSNNLFVLSDDKKFPYKKYREAGGNFATWSITPDSSTQPYWKWFICHFRSELEVKYGKKFTNLGKIPDSWNKITKQEVLDDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FS85</accession>
    <name>A0A9J7FS85_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Potassium channel subfamily K member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Kcnk7</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027264993.1">
        <property type="nucleotide sequence ID" value="XM_027409192.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FS85"/>
    <dbReference type="GeneID" id="100763826"/>
    <dbReference type="KEGG" id="cge:100763826"/>
    <dbReference type="CTD" id="10089"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000154">
        <property type="entry name" value="Potassium channel subfamily K member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005408">
        <property type="entry name" value="2pore_dom_K_chnl_TWIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF31">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01586">
        <property type="entry name" value="TWIKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18 23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 16" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5 16" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 16 18" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="21">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="21">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="279"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="17">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR038061-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027264993.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="33650" checksum="6612EF8774B482F3" modified="2023-06-28" version="1">MRSLKPWARYLLLLVAHLLAMGLGAIVLQALEGPPALQLQTQLQAELSAFQAEHRACLPPEALEELLSAALRAQAHGVSSLGNSSGSGSSSEASNWDLPSALLFTASILTTTGYGHMAPLSAGGKAFCVFYAALGLPASLALVAALRHCLLPVFNCPGAWVAVRWRLAPAQAALLQAAGLGLLVACVFVLLPALVLWGIQGDCSLLEAIYFCFGSLSTIGLGDLLPGHGRGLHPAIYYLGQFALLGYLLLGLLAMLLAVETFSELPQIRALVKFFGPSGSRTDEDQDGILGQDELALSTMPPDPPALEQTTPASASEQSPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FTY2</accession>
    <name>A0A9J7FTY2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NF-kappa-B inhibitor zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">I-kappa-B-zeta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">IL-1 inducible nuclear ankyrin-repeat protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Molecule possessing ankyrin repeats induced by lipopolysaccharide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Nfkbiz</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with NFKB1/p50. Interacts with RELA. Interacts with AKIRIN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027268316.1">
        <property type="nucleotide sequence ID" value="XM_027412515.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FTY2"/>
    <dbReference type="GeneID" id="100759240"/>
    <dbReference type="KEGG" id="cge:100759240"/>
    <dbReference type="CTD" id="64332"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070974">
        <property type="term" value="F:POU domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000179">
        <property type="entry name" value="NF-kappa-B inhibitor zeta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000188">
        <property type="entry name" value="NF-kappa-B inhibitor zeta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047571">
        <property type="entry name" value="OCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF5">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52003">
        <property type="entry name" value="OCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCA" evidence="16">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="290"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027268316.1"/>
        </source>
    </evidence>
    <sequence length="736" mass="80285" checksum="A2883DAA00120E8F" modified="2023-06-28" version="1">MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPSAPGAGDAGYLSAVPSAPGSPGSDSSDFSSTSSVSSCGAVESRPRGGARAERPQVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKTSSLSVDEFKAQSVNIEQLTEVKSTVSAVGKRKGTDPLSDGPVCKRPALLSTHFVTSPQTPTSGESMEDVRPNESKLDSSADLLQNIINIKNECSSVSLNTVQVSWMSPAVPQNSPRDQCQDFHGGQVFSPPQKYQPFQVSGSPQMMDQASMYQYLPQTQSMQQQPQPQQQQQQQQQQQQQQQQQNYPHNPALQFSSCSRTSQSPKYESNLFDSQDPQFCTSQSFVSLLSGHGESENIAVPLQPSSSIPQQNETHLQSFSLMPNNACEAGRVHDAGSPSLGTSLSLQNIMGSPMNTTQLGKSFFQWQVEQEESKLANISQDQFLYKDSDGDTFLHIAVAQGRRALSYVLARKMNAFHMLDVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQFVDLEATNYDGLTPLHCAVLAHNAVVHELQRNQQPHSPEVQDLLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FZR7</accession>
    <name>A0A9J7FZR7_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein C14orf28 homolog isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CUNH14orf28</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027272290.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FZR7"/>
    <dbReference type="GeneID" id="100755612"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040029">
        <property type="entry name" value="C14orf28-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35350">
        <property type="entry name" value="HYPOTHETICAL LOC314168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35350:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC314168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027272290.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="40221" checksum="19C33AC25F86A7B3" modified="2023-06-28" version="1">MRRGAAAAAAPGLSMSERRRRRVRRHGGLRSRGRMKTLFEEIKASIKNNYNQDRSFWRPVLPWGGVFTIKAGRKAVSCTPLYVEIRLKNTCTIDGFLMLLYVILNENESFPRELSLHFGREFVDCFLYLMDTYSFTTVKLLWIWDKMEKQQYKSEVHKASLIIDLFGNEHDNFTKNLENLMSTIQESYCSNWRCPTRVQEDQQRTISINPPQEIPHGNLIRLAVDELFCSKIELCEERGCGGLREFSQRIFCHGAPPFVVLNMQHWKPEDLAYVPYYLDLSDHKYLLEGATLFNKEEHHYSAAFQIDGHWMHYDGLRNVNLILLNKPPEFLLLSSLVYIRATEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FZS5</accession>
    <name>A0A9J7FZS5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein phosphatase non-receptor type 9</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Ptpn9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003497982.1">
        <property type="nucleotide sequence ID" value="XM_003497934.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270805.1">
        <property type="nucleotide sequence ID" value="XM_027415004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FZS5"/>
    <dbReference type="GeneID" id="100765899"/>
    <dbReference type="KEGG" id="cge:100765899"/>
    <dbReference type="CTD" id="5780"/>
    <dbReference type="OrthoDB" id="10051650at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14543">
        <property type="entry name" value="PTPc-N9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000005">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000026">
        <property type="entry name" value="tyrosine-protein phosphatase non-receptor type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF285">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="12">
        <location>
            <begin position="92"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="311"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="489"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027270805.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="68768" checksum="E82DC90EAFD165E2" modified="2023-06-28" version="1">MQGLVQAKPGGIVPVLKAKNNILTSRGTEATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHAYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEITQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALHWDSVHVPGPHAMTIQELVDYVNTRQKRGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRVRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQRQAVSSLGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVPSGHSLLATEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G026</accession>
    <name>A0A9J7G026_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="23">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">Atp2b4</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 23">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with calmodulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Cell projection</location>
            <location evidence="21">Cilium</location>
            <location evidence="21">Flagellum membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="23"/>
    <dbReference type="RefSeq" id="XP_016832759.1">
        <property type="nucleotide sequence ID" value="XM_016977270.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273382.1">
        <property type="nucleotide sequence ID" value="XM_027417581.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G026"/>
    <dbReference type="GeneID" id="100764868"/>
    <dbReference type="CTD" id="493"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070885">
        <property type="term" value="P:negative regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000011">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000022">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF435">
        <property type="entry name" value="PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 23" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="16 23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 23" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="920"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="995"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1028"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00062373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027273382.1"/>
        </source>
    </evidence>
    <sequence length="1238" mass="137389" checksum="D74937AD3444D2A3" modified="2023-06-28" version="1">MTHPSTHNVRSSSVPENYEGEFGCTLMDLRKLMELRSADAVAQINSHYGGVQDICARLKTSPVEGLSGNPLDLEKRRLVFGQNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGGDNEMCGQATSGPDEEEEAETGWIEGAAILTSVIIVVLVTAFNDWSKEKQFRGLQSRIELEQKFCIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGASEEDEEENKKKGKKQGVSENRNKAKTQDGVALEIQPLNSQEGFDVEEKEKKIMKIPKKEKSVLQGKLTRLAVQIGKAGLLMSTLTVVILILYFVIDNFVIQRRAWLPECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMRDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQACIGGTHYHQIPSPDIFPPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRSEVPEEKLFKVYTFNSVRKSMSTVIRKPEGGFRMFSKGASEIMLRKCNRILDKGGEAIPFRSKDRDDMVHSVIEPMASEGLRTICIAYRDFDDTEPIWDNENEILTELTCIAVVGIEDPVRPEVPDAINRCKRAGITVRMVTGDNVNTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRKKPLISRTMMKNILGHAVYQLTVVFVLVFVGEKLFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFAGIYHNAIFCSVVLGTFICQIFIVEFGGKPFSCTKLNLEQWLWCLFIGIGELLWGQVISAIPTKSLKFLKEAGHGADKEEITQEAEGMEEIDLAEMELRRGQILWFRGLSRIQTQIEVINTFQTGASFKGVLKRQNMSQHLDVKLVPSSYSTIKVVRVLHNFHQVVHKPRNQHSIHHFMTQSGYNADDEFPHSFQDDQEEDAPRAGTRVLLLDGEATPYDNKNNNAVDCNQVQIVASHSDSPLHSLETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G4P1</accession>
    <name>A0A9J7G4P1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100762637</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cell membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003505221.1">
        <property type="nucleotide sequence ID" value="XM_003505173.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276931.1">
        <property type="nucleotide sequence ID" value="XM_027421130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G4P1"/>
    <dbReference type="GeneID" id="100762637"/>
    <dbReference type="KEGG" id="cge:100762637"/>
    <dbReference type="OrthoDB" id="9577527at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15410">
        <property type="entry name" value="7tmA_OR5D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 14 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="45"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027276931.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35759" checksum="F3108529D6CCAFB0" modified="2023-06-28" version="1">MPMMFDDRNQTFLTTFFLLGFSEDTMFQVPLFFLFLTIYFIALMGNLGIIVVRKINPKLQTPMYFFLSHLSFLDICYSSVFTPKLLEILITEDKTISFRGCMAQFFFGCACVITEMFMLAVMAYDRFVAVCNPLLYTMAMSQKLCMFLVAGTYMWGGLGSFTLTYTLLKLSYCGPGIINHFGCEFSAILSVSCSDPSLSQLACFIVSVLSEAFSLLIILASYVFIVVTIIKMPSKGGLRKAFSTCASHLTAISIFHGVVLLLYCIPNSKNSWLLVKVATVLFTVVIPMLNPLIYSLRNKDVKETIRKLINSKLYSHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GBS4</accession>
    <name>A0A9J7GBS4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 14">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="14">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Srp68</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently. The SRP complex possibly participates in the elongation arrest function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer with SRP72. SRP68/SRP72 heterodimer formation is stabilized by the presence of 7SL RNA. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Within the SRP complex, interacts (via C-terminus) with SRP72 (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027281408.1">
        <property type="nucleotide sequence ID" value="XM_027425607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760316"/>
    <dbReference type="KEGG" id="cge:100760316"/>
    <dbReference type="CTD" id="6730"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000001">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 14" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027281408.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="70834" checksum="DBD0B900395179F4" modified="2023-06-28" version="1">MAAEKQVPXGGRRRRGGGGGGGGGGGGGGRSAGGEENKENERPSAGSKASREFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLASAFTEEQAVLYKQRVDEIAPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVKIDRVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDALQAVREELKPDQKQRDYTLDGESGKVSNLQYLHSYLTYIKLSTAIRRNESMAKGLHRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLAELLQLPGLEEDRAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYADEVSADGGAFKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDSHQAEPSSQVKDNKPLVERFETFCLDPSLVTKQASLVHFPPGFQPIPCKPLFFDLALNHVAFPPLEDKLEQKTKSGLTGYIKGIFGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GCU9</accession>
    <name>A0A9J7GCU9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B9d1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the tectonic-like complex (also named B9 complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007647441.1">
        <property type="nucleotide sequence ID" value="XM_007649251.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283043.1">
        <property type="nucleotide sequence ID" value="XM_027427242.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GCU9"/>
    <dbReference type="GeneID" id="100774531"/>
    <dbReference type="KEGG" id="cge:100774531"/>
    <dbReference type="CTD" id="27077"/>
    <dbReference type="OrthoDB" id="431939at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027283043.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25361" checksum="21DC0CECDD06DABE" modified="2023-06-28" version="1">MACHPFPRQPGSLLATARGLRRSPGPVVPWLLQVPASSCSWSTGRWRAPSFQSMMTSTASTALCMARTGPPRRVWRRGSHRSHPRAKMYGKHWCGTSPSMSPLKVPTPMAIVLSVYGPDVFGNDVVRGYGAVHVPFSPGRHKRTIPMFVPESTSTLQKFTSWFMGRRPEYTDPKVVAQGEGREVTRVRSQGFVTLLFNVVTKDMKKLGYDTGPVDTQGVLGPSLPQVNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GCY7</accession>
    <name>A0A9J7GCY7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Cops3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG. Interacts with ERCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016831570.1">
        <property type="nucleotide sequence ID" value="XM_016976081.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283121.1">
        <property type="nucleotide sequence ID" value="XM_027427320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GCY7"/>
    <dbReference type="GeneID" id="100760692"/>
    <dbReference type="KEGG" id="cge:100760692"/>
    <dbReference type="CTD" id="8533"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000354">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000008">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048621">
        <property type="entry name" value="CSN3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21215">
        <property type="entry name" value="CSN3-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="11">
        <location>
            <begin position="197"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027283121.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50538" checksum="5098344159282D86" modified="2023-06-28" version="1">MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKACHAPWSLYKLRYSGSEEPELRQNSTEKEELEGVSPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GDV9</accession>
    <name>A0A9J7GDV9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Dynamin-1</fullName>
            <ecNumber evidence="4">3.6.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Dynamin I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">Dnm1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Chromaffin granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027279633.1">
        <property type="nucleotide sequence ID" value="XM_027423832.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GDV9"/>
    <dbReference type="GeneID" id="100753867"/>
    <dbReference type="KEGG" id="cge:100753867"/>
    <dbReference type="CTD" id="1759"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042583">
        <property type="term" value="C:chromaffin granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098835">
        <property type="term" value="C:presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000019">
        <property type="entry name" value="Dynamin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000014">
        <property type="entry name" value="Dynamin 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000045">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000555">
        <property type="entry name" value="dynamin-1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF32">
        <property type="entry name" value="DYNAMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0168">Coated pit</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14 24" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-0944">Nitration</keyword>
    <keyword evidence="10 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="28">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="26">
        <location>
            <begin position="519"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="27">
        <location>
            <begin position="659"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="767"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00073713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00075371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027279633.1"/>
        </source>
    </evidence>
    <sequence length="868" mass="97767" checksum="80022B960A6A227B" modified="2023-06-28" version="1">MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRKGPASPTRPAAPRPAEVPLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GED3</accession>
    <name>A0A9J7GED3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neuromedin-U receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Nmur2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for the neuromedin-U and neuromedin-S neuropeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282009.2">
        <property type="nucleotide sequence ID" value="XM_027426208.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GED3"/>
    <dbReference type="GeneID" id="100758157"/>
    <dbReference type="KEGG" id="cge:100758157"/>
    <dbReference type="CTD" id="56923"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000214">
        <property type="entry name" value="Neuromedin U receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005392">
        <property type="entry name" value="NeuromedU_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045561">
        <property type="entry name" value="NMU-R2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF14">
        <property type="entry name" value="NEUROMEDIN-U RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19285">
        <property type="entry name" value="NmU-R2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01567">
        <property type="entry name" value="NEUROMEDNU2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="54"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027282009.2"/>
        </source>
    </evidence>
    <sequence length="468" mass="53012" checksum="94678DA745A8192F" modified="2023-06-28" version="1">MGKLENASWIYDPLMKYLNSTEEYLAHLCGPRRSHLSLPVSVAYALIFVVGVMGNLLVCLVILRHQTLKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWYNYPFLFGSVGCYFKTALFETVCFASILSVTTVSIERYVAIVHPFRAKLESTRRRALRILSLVWGFSVVFSLPNTSIHGIKFQYFPNGSSVPGSATCTVTKPMWVYNFIIQATSFLFYILPMTIISILYYLMGLRLKRDESLEADKVSVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVEEWTESLATVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPSCKWCHSQDLPPGPPAQKIIFLTECHLVELTEDAGPHFPCQSSIYNSHLSTAPCAGQLFRSVIQRLMASVVVAVVVMMMMVMMSDSNGDDGDDDDELESRRQSQLLLPEHLMELGVSSSKWWFMPGTGVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GP15</accession>
    <name>A0A9J7GP15_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Graves disease carrier protein homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC113837880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289504.1">
        <property type="nucleotide sequence ID" value="XM_027433703.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GP15"/>
    <dbReference type="GeneID" id="113837880"/>
    <dbReference type="KEGG" id="cge:113837880"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027289504.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8079" checksum="0E71E372F908BFFB" modified="2023-06-28" version="1">MAAAAALAAADPAPAVPQAAGSGGPASRRDLYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGSLYIALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GSN3</accession>
    <name>A0A9J7GSN3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein Ccdc162p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ccdc162p</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035294296.1">
        <property type="nucleotide sequence ID" value="XM_035438405.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296256.1">
        <property type="nucleotide sequence ID" value="XM_035440365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751702"/>
    <dbReference type="KEGG" id="cge:100751702"/>
    <dbReference type="CTD" id="221262"/>
    <dbReference type="OrthoDB" id="76966at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040401">
        <property type="entry name" value="CCDC162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029376">
        <property type="entry name" value="DUF4549"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33331:SF13">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33331">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15082">
        <property type="entry name" value="DUF4549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4549" evidence="3">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1764"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1973"/>
            <end position="2053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035296256.1"/>
        </source>
    </evidence>
    <sequence length="2204" mass="251739" checksum="E1810EA1D59BA69C" modified="2023-06-28" version="1">MDSVYELSSTERVQQLEKDLAGKLGELKDELEEQGALPRTTNWTFSSVQIPKDVAHFRREREVALKRTLGVAECKPLVIQADVLQRELESCLRREYTPENLPLLLLQHYTERITQLVQNKYLHMLRWRRLCQTSGTMEELHPLYKKQVGYIMQEFNDAVQRAERLAVARENFLMGKSNPPHLVTPEDLTIYTRWLVCHLHSLGTIHHYLQVLQYVPISRALQSPADNQVSELSEEKEKEKVCVADLNSESPGPMDASISGPGRTRATFVLPQHVTEKEQLKPQLRHLLSHFHVLYDLQKLSDSAKEMELFSLVSQSFQSIFMEQQRMRTFPDYEAGRASVQNLSGPATTLKKRATWIPFVKVKPKCDPWQKKMLTRLKERRRTDELMQLQSKILKISDPVKVMQVLQEHAARTVTMAPCHSSFMTSQALHLCNYDQVWQNIYSNTKLYQNENVKDDGLSVEPSDEDLAKIRLSQSSDGSLKQRTETGYNYAVALQLLGLSDGTEPDQNPVLTRGAYLSFLCLRHLHIRELQRICLGVLNYFRSVERTLTINTSGLTLVSGKLVPTVGDNSWINMAKGGLGTSQGLGDHHYVHRTPAEHKVHGVQFLEFSEVENQDDFHSTQAGCVHTQDQLGLYVMYDYALQDLKELESELLLIASHYIEKEKSHREDGKSENRQRWGWAHANVDRFAVLYDLWTWEANLLESKRQLLDSYLEAYQHTLDPEEGFTLAQAMTDIIHRRPKFDLGHSYFTKAYQDDCACLRLHRQLVRSVLSHLLEQQREYVRRLWRGDHPEAHKTFGLPPNIICKQFVSINNSCPASENVHLLELHPSLGLVGLIPKALEHLFREARHSHKPSSPSGLAQLEQRLLQLALDLWLTPAKPEAWYSAQLQRDLFSAKVMGDPFLVEEVGLLALRSAVDKEQKQGQDFHALLLETFSNLLELLTLRHRLIEMNVESAHLARLYKELAQEMGFEEFHLYMRPVPFEFVSHKDKVDLPPPVFMTSLLEDSSQVDRYSPTALVLAITELGDNQIGKFSFYTKDAILKLLFHSGVENMQMSLACQATQKNALMAAIQQAAFYDIPGTDSPGDAKETSSAPRHHGRMSPARRGSRTESGIECLLSAPTPKAPDTLTHSSGLKTTKRVPEAFVSIQLEKVGFRDLMLNTFIHRKQTMADRMESPDDIEKIKRELIVEYCQKLNDHMSHYALRGQIMAYCNSLRVLLDDFPTIRDTFFMVGQPSEKKGLKDSSGEFKADPRSFQRRPRSLLSADGRVFLNLWFIPHPSEVLCMFKTLPEEAAFRALKLTLQLVAPLHDIVAYLFSFAKLGNFPACFDSPLSPGPLRNDWGGPEGIGSELQELQKMIDSLLSPQDPSQVAQALLLRREVTWLQFDAAMRHLLRTFLAAGNAPAHQSVADGVCHGLPPLSNCLRRSIFSSQLSLPQPLDPRSPRAFSMFPWRAFLEDGGPFPVMSSIPNTLEYDMQMCLCGLSDRDRKVAHVELVGVQALMEDVLLSGSHVITDHSPERQATQYNTQLDWSKRLGLCPSQLESHAKASALLEGPCEAVMPFALLKCFLVLWKQLEVLKEHWGRLKLQGQEINSAPLHKQFSELYEADIFYPSMKALARRVGKEDEFEELIIRSQSILPPMGASEIEIKAQQLQKLLESLEIHMIQEVMRKVSREMTLLLSEKSNKEPTLPTDLWKHQVMKENFSVVRPQIVERFVQRLMESSQEDGPEITFRRDHLEACLLSLGCDVMARERSNFETYSMCYEHVLQHAREKLSQREQEVDLLRRSQLPPEDCAGQVAELSHDLIMEITALRAQLTDLEEESLNLKNQIRKEIQEEYRSLVQALFMTCVHIKEKLDENQFNLIQKMCELIGEVRAEGIANIKQLKKAWGSARPEEGAKENTAEEQLCPLEQASSGTLAAIVCKMQSLGRWRLAVQQARLTGQLSRAEKESIHSQRECLRIKLMAEQEVGLLHQQLLAARQALAEAHTDNRKLRQQQDTQAQLLRELEHRVTQDSVTRQQLEIIKTSGMEKLLEDVEQKEQQLQLLTAEAERASKLGQLRWRKMDRDLQQMRSRLAQERSVKLDAFHRVRELQSQLHDMEQPSLQMGSSSGLISQIHCPLNSASALSRCSHHFPKTNLPSNKMTRRTQRPKTVPIKNKRRIDDGFLPNVAENVQLTTSQVQTAPSRISFRHDSFSSQHVADSIEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUK7</accession>
    <name>A0A9J7GUK7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial</fullName>
            <shortName evidence="1">Glu-AdT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100762845</name>
        <name evidence="1" type="synonym">GATC</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035299140.1">
        <property type="nucleotide sequence ID" value="XM_035443249.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317282.1">
        <property type="nucleotide sequence ID" value="XM_035461391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GUK7"/>
    <dbReference type="GeneID" id="100762845"/>
    <dbReference type="OrthoDB" id="5394539at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035299140.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23720" checksum="172029B5D2C06153" modified="2023-06-28" version="1">MSVQASPTLFMAMATAATATSAHPDVVSIARVAPPSSLRRTRSKEMWARALRVRFPATLNRGRGFASKAGPQGKVQEAGQGTHSPRLATQGAGRVPAAKIEHLERLALVNFGSREAVARLEKAIAFADQLHAVDTDGVEPLESVLEDRCVYLRSDNVAEGNCTEELLRNSHHVVEEYFVAPPEMNPQPRNFPKNGQHSYLNKKAHLYTPAHILTPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUR3</accession>
    <name>A0A9J7GUR3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein argonaute-2</fullName>
            <shortName evidence="11">Argonaute2</shortName>
            <ecNumber evidence="11">3.1.26.n2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Eukaryotic translation initiation factor 2C 2</fullName>
            <shortName evidence="11">eIF-2C 2</shortName>
            <shortName evidence="11">eIF2C 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein slicer</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Ago2</name>
        <name evidence="11" type="synonym">AGO2</name>
        <name evidence="11" type="synonym">EIF2C2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.n2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA-and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.n2" evidence="11"/>
    <dbReference type="RefSeq" id="XP_035296547.1">
        <property type="nucleotide sequence ID" value="XM_035440656.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317436.1">
        <property type="nucleotide sequence ID" value="XM_035461545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GUR3"/>
    <dbReference type="GeneID" id="100760040"/>
    <dbReference type="CTD" id="27161"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070551">
        <property type="term" value="F:endoribonuclease activity, cleaving siRNA-paired mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035278">
        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035279">
        <property type="term" value="P:miRNA-mediated gene silencing by mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000005">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03031">
        <property type="entry name" value="AGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028602">
        <property type="entry name" value="AGO2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 11" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="13">
        <location>
            <begin position="231"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="14">
        <location>
            <begin position="519"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-hydroxyproline" evidence="11">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035296547.1"/>
        </source>
    </evidence>
    <sequence length="861" mass="97432" checksum="10A9EF7F724B486C" modified="2023-06-28" version="1">MSPQRAGAVLASPAPTTSPLQGYGFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLSSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUT0</accession>
    <name>A0A9J7GUT0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin-16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Kidney-specific cadherin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Cdh16</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035297319.1">
        <property type="nucleotide sequence ID" value="XM_035441428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GUT0"/>
    <dbReference type="GeneID" id="100761107"/>
    <dbReference type="KEGG" id="cge:100761107"/>
    <dbReference type="CTD" id="1014"/>
    <dbReference type="OrthoDB" id="8804268at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000167">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000187">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000195">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000240">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000241">
        <property type="entry name" value="Cadherin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000149">
        <property type="entry name" value="cadherin-16 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000159">
        <property type="entry name" value="cadherin-16 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF424">
        <property type="entry name" value="CADHERIN-16 ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039898155" description="Cadherin-16" evidence="17">
        <location>
            <begin position="24"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="128"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="338"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="452"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="566"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035297319.1"/>
        </source>
    </evidence>
    <sequence length="830" mass="90311" checksum="F3126F3C03EE3965" modified="2023-06-28" version="1">MISAWLWWFCLIVIQVFSAKAQSAELHVEIPENYGGNFPFYIIKLPLPLGRDEGQIVLSGDSSTADQELFAVDPDSGFLMVKKALDREEKAEYQLQVTLESEDGHILWGPQLVTVHVKDENDQVPQFSQAIYRARLSQGTSPGIPFLFLEASDGDAPGTANSDLRFHILSQSPTQPLPDMFQLDPRLGSLALSPKGSNSLDQALEETYQLLVQVKDMGDQASGHRAIATVEISIVQSTWVPLEPVHLAENLRVAYPHSIAQVHWNGGDVHYQLESQPPGPFDVDAEGRIHVTMELDREAQAEYLLQVRAQNSHGEDYAEPLELQVVVMDENDNAPVCSPHGPTISIPELSPPGTEVTTLSAEDMDAPGSPNSHVVYQLLSPKPEEGAEEKAFELDSTSGSVTLGTAPLHAGQDILLQVLAVDLAGSEGGLSSTCEVSVMITDINNHAPEFLTSQFGPVSLPEDSKPGVLVATLRATDADLEPVFRLMDFAIEEGDPKGIFDLAWEPDSDHVQLRLQKNLSYEAAPHHKVVVVVRNVEELVGTDPGPGATATVTILVERVMPPLKLDQESYETSIPVSTPAGSLLLTIQLSEPMSRTLRFSLVNDSEGWFCIKEVSGEVHTAQSLQGAKPGDTYTVLVEAQDTDEPRLSASATIVVHFLKASPVPALTLAPGPSRHLCTPREDYGVVVSGASEDHDLANGHGPYSFALGPNPTVQRDWRLHPFNDSHAYLTLALHWVEPGEYMVPVVVRHDAQMWQLQVQVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGVLLGTLAAIGFILILVFTHLALARKKDLDQPADSVPLKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZ42</accession>
    <name>A0A9J7GZ42_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Hepatocyte growth factor-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Mst1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035299844.1">
        <property type="nucleotide sequence ID" value="XM_035443953.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310435.1">
        <property type="nucleotide sequence ID" value="XM_035454544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GZ42"/>
    <dbReference type="GeneID" id="100761444"/>
    <dbReference type="CTD" id="4485"/>
    <dbReference type="OrthoDB" id="41905at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.20.10:FF:000002">
        <property type="entry name" value="Hepatocyte growth factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000055">
        <property type="entry name" value="Hepatocyte growth factor-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.20.10:FF:000009">
        <property type="entry name" value="Hepatocyte growth factor-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.4.10:FF:000004">
        <property type="entry name" value="Hepatocyte growth factor-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024174">
        <property type="entry name" value="HGF/MST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050759">
        <property type="entry name" value="Serine_protease_kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261:SF12">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261">
        <property type="entry name" value="PLASMINOGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001152">
        <property type="entry name" value="HGF_MST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0420">Kringle</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0721">Serine protease homolog</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Apple" evidence="12">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="10">
        <location>
            <begin position="199"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="10">
        <location>
            <begin position="280"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="10">
        <location>
            <begin position="410"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="10">
        <location>
            <begin position="525"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="636"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035299844.1"/>
        </source>
    </evidence>
    <sequence length="863" mass="95881" checksum="F77F5DD33A476E85" modified="2023-06-28" version="1">MPNVSPQNPPKHCLINIKDSQGSSYIKKVLALDPRARGLTSPSNCHPVSVKPKQVQRGGVEPEPPNPVGTHFTISGMGLWWVTAQPPAMSMRWFPLLLLLTQCSRALGQRSPLNDFQLLQSTELKNFLHTVVPGPWEEDVADAEECARRCGPLLDCRAFHYNSSSHGCQLLPWTQHSPHTQLHHSSLCDLFQKKDYVRACIMDNGVSYRGTVARTAGGLPCQAWSRRFPNDHKYTPTPKNGLEENFCRNPDRDSRGPWCYTTNPSVRFQSCGIKSCREAVCVRCNGEDYRGEVDVTESGRECQRWDLQHPHSHPFQPDKYVGRILMPRVGLNPTGEGPESQSLITTPRFLDKALNDNYCRNPDGSERPWCYTTDPNIEREFCDLPSCGPNLPLITKGSKSHQRNKGKILNCFHGKGEDYRGTTNTTSAGVPCQRWDAQSPHQHRFVPEKYSCKDLRENFCRNPDGSEAPWCFTSRPGLRVAFCYQIPRCTEEVVPEGEAGAGGRGGQESGTDLGLMAALAPSTAGCYHGSGEQYRGLVSKTRKGVQCQHWSAVTPHKPQFTPTSAPQAGLEANFCRNPDGDSHGPWCYTSDPATLFDYCALQRCDDDQPPSILDPPDQVQFEKCGKRVDKRNKLRVVGGHPGSSPWTVSLRNRQGQHFCGGSLVKEQWVLTARQCVWSCHEPLTGYEVWLGTINQNPQPGEANLQRVSVAKAVCGPAGSQLVLLKLERPVILNHHVARICLPPEQYVVPPGTKCEIAGWGESTGTSNNTVLHVASMKVISNQECNVKHRGHVQESEMCTEGLLVPTGACEGDYGGPLACYTHDCWVLEGLIIPNRVCARPHWPAVFTRVSVFVDWINKVMQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZK0</accession>
    <name>A0A9J7GZK0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Receptor-type tyrosine-protein phosphatase C</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Leukocyte common antigen</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">T200</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">Ptprc</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes. Binds GANAB and PRKCSH. Interacts with CD53; this interaction stabilizes PTPRC on the membrane and is required for optimal phosphatase activity. Interacts with CLEC10A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035301719.1">
        <property type="nucleotide sequence ID" value="XM_035445828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GZK0"/>
    <dbReference type="GeneID" id="100761948"/>
    <dbReference type="KEGG" id="cge:100761948"/>
    <dbReference type="CTD" id="5788"/>
    <dbReference type="OrthoDB" id="5794147at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14558">
        <property type="entry name" value="R-PTP-C-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14557">
        <property type="entry name" value="R-PTPc-C-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001462">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000033">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000042">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
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        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024739">
        <property type="entry name" value="PTP_recept_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016335">
        <property type="entry name" value="Ptprc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF539">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12567">
        <property type="entry name" value="CD45"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12453">
        <property type="entry name" value="PTP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002004">
        <property type="entry name" value="Leukocyte_common_antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="31" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 26" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 25" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039948465" description="Receptor-type tyrosine-protein phosphatase C" evidence="26">
        <location>
            <begin position="26"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
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            <begin position="323"/>
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            <begin position="413"/>
            <end position="505"/>
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        <location>
            <begin position="582"/>
            <end position="841"/>
        </location>
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        <location>
            <begin position="761"/>
            <end position="832"/>
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            <begin position="873"/>
            <end position="1156"/>
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            <begin position="1064"/>
            <end position="1147"/>
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        </location>
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            <begin position="1182"/>
            <end position="1233"/>
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            <begin position="928"/>
            <end position="941"/>
        </location>
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            <position position="782"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="23">
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            <position position="1097"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004251"/>
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            <dbReference type="ARBA" id="ARBA00004285"/>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H1N7</accession>
    <name>A0A9J7H1N7_CRIGR</name>
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    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">17A/GY</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
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            <end position="213"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="760" mass="87930" checksum="11731A0626025775" modified="2023-06-28" version="1">MAKSPGNSTLEDSLGQYQRSLRERANRSIHQLKCALRDVDVTVEEGALDPSASINVENEDTEMAWHELQHSHAVSQLKALLRQQASKDNEISPPRRRKMSPLRPSECEDNSTPTVYNLVPIINDQSQYIHHLEAEVKFCKDELSGMKNRVQVVVLENERLQQELKSQRQEETLREQTLLDASGNIQDSWIKTGEDSRVDEAAKRPFSHGDAESGKTTSTGDAEKWKLELERLKLTYEAKSELLESQLMLLRKDLVEYQQNCEDLKERLKHKDSLLATGVSSRVGGLCLKCAQHEAVLSQTHSNVHIQAIETMTKERDDLMSALVSVRSSLAEVQQRETSAYKQVKHAVQMTEEANFEKTKALIQCEQLKSELDRQTERLEKELAAQQEKRALEKEMIKKEVTKEREDAESKMLILSQNIAKLEAQVETVTREKISAVNQLEEIQNQLASQEVDVRKVCGEMRFQLNKTKMEKEEAEKEHREYKAKSQKDLEMKDQEIEKLRLELSESKQHVEQEQQKAARAREECLQVTELLGESERQLHLTRVLTFAEVQEYSHCWQYPGTGNTHSVHPKMWKTPCHLLRLEKDSIQQSLSNEAKAQALQAQQREQELTQKIEQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEKMSQKSRSEIVRLSQEKMYMCDKLEKIQKRNDELEEQCIQHGRVHESMKERLRQLDKHGQATAQQLVQLLNKQNQLLLERQSLSEEVDRLRAQIGKLRLKQAYSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2K5</accession>
    <name>A0A9J7H2K5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100758984</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035302941.1">
        <property type="nucleotide sequence ID" value="XM_035447050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758984"/>
    <dbReference type="KEGG" id="cge:100758984"/>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF3">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="407"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035302941.1"/>
        </source>
    </evidence>
    <sequence length="674" mass="73978" checksum="93F73792A32E19E0" modified="2023-06-28" version="1">MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSSVPTEGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEQWAADPDMYLQSPQSERTDPHGLYLSCNGGTPAGHRQMPWPEPQSPQALPNGLAAKTQSLGPAEFQGASQRCLQLGACVQSSPPGTSPPMATGRRGVKAAKHNSEEVRPQSCLVGSAIGRPGGEGSPNPKNQESSLKHRLFRSMFLSTPATGSASSSKPVPLPQNKLHSAFRPPQKDSSSNLVAKAQSLPSDQPMGTFSPLTTSDTSSPQKSLRTVPAAGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALAGEDTGIVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPXXAMASSHCSAPQVSPVLRDFLERMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H8E3</accession>
    <name>A0A9J7H8E3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Map3k15</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035305644.1">
        <property type="nucleotide sequence ID" value="XM_035449753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H8E3"/>
    <dbReference type="GeneID" id="100751831"/>
    <dbReference type="KEGG" id="cge:100751831"/>
    <dbReference type="CTD" id="389840"/>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06624">
        <property type="entry name" value="STKc_ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000054">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000067">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046873">
        <property type="entry name" value="HisK-N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043969">
        <property type="entry name" value="MAP3K_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025136">
        <property type="entry name" value="MAP3K_TRAF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF363">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19039">
        <property type="entry name" value="ASK_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20302">
        <property type="entry name" value="HisK-N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13281">
        <property type="entry name" value="MAP3K_TRAF_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="523"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035305644.1"/>
        </source>
    </evidence>
    <sequence length="1197" mass="136610" checksum="6C6AE363B1E0AAFF" modified="2023-06-28" version="1">MYFLDFSVLKIEYIVCLLKASSGNYYFIPYTVTPCADYFCCESDAQRRASEYMQPNWDTILGPLCMPLVDKFTSLLKDIRVTSCAYYKETLLNDIRKAREKYQGDELAKELTRIKFRMDNIEVLTSDIIINLLLSYRDIQDYDAMVKLVETLKMLPTCDLADQHNIKFHYAFALNRKKEVGSLFLQIRDVIHEQGRTPMEGIWRNSTGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLASDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIQRFKKPITEYSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQIHEWNFTPSSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEDQCNRFCSLVKEMLNNGVGSTVELEGEADGDTLEYEYDHDVNGERIVLGKGSYGIVYAGRDLSNQVRIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGINPCTETFAGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPESLSTEARAFILSCFEPDPHKRATAANLLQEGFLRQVNKGKKNRIAFKPSESVRSATGTLALPSAGELMCSSSSEHGSVSPDSDAQHDAFFEKTQVPKHQLSHLLSVPDESAALEDRSTALSPEERDPGLFLLRKDSERRAILYRILWEEQNQVASNLQECVVQSSEELLLSVGHIKQIIGILRDFIRSPEHRVMAATISKLKVDLDFDSSSINQIHLILFGFQDAVNRILRNHLIRPHWMFAMDNIIRRAVQAAVAILIPELQAHFEPASETEGVDKDTEVEGDYPLVDLLGQVHMTPRGTRPGSVGIQEGQPNQQDPTLQLSKLRQENNRLWEHLVQKEREYQNLLRLTLEQKTQELHHLQLQYKSSGGTENPVPPDEVGTDRELIDWLQLQGADANTIEKIVEEDYTLSDILNDITKEDLRCLRLRGGVLCRLWHAVSQHRRQMQESSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HAH7</accession>
    <name>A0A9J7HAH7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: retrotransposon-derived protein PEG10 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Peg10</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035307822.1">
        <property type="nucleotide sequence ID" value="XM_035451931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763982"/>
    <dbReference type="KEGG" id="cge:100763982"/>
    <dbReference type="CTD" id="23089"/>
    <dbReference type="OrthoDB" id="9445845at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF31">
        <property type="entry name" value="RETROTRANSPOSON-DERIVED PROTEIN PEG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035307822.1"/>
        </source>
    </evidence>
    <sequence length="718" mass="81164" checksum="83059A314C65019B" modified="2023-06-28" version="1">MATAAGGAGCPPPPPPNNNNNNNKSKSPRNGGRRRRNRRQSRNSDSDPELQGATADPSFFLDEDCLEYLPEKFDGNPDALTPFIAQCQVFMEKSSRDFSVDRTRVCFVTSMLHGRAARWATAKLERCNYLMNNYRAFMLELKHVFEDPQRREAAKRKIRRLRQGAGTVSEYAGIFQSVAQDLDWDESSLVDQFLEGLNQQIHQELSRRSEVPTNLNDLIRLCIHIERRLVRLAAEAASRPRDPPRGLGLPLPQSSQSDPTEPVGGARMRLTQEEKERRRKLNLCLYCGNGGHYADNCPAKGNNNRNSPXGKLPGPAVEGRAATGPERTRSPTPEAPTSHLQVMLQIHIPGRNTLFVRAMIDSGASGNFIDQEYVIQNAIPLRIKEWPIMVEAIDGHPIASGPIVLETHHLIVDLGDHREILSFDVTQSPFFPIVLGVRWLSTHDPHITWSTRSIVFNSDYCRFYCRMYSQIPPPMLLPVPHPPHLPFFYHVDGYRVYQPVRYYYVQNVYTPVDEHAYPGHRLVDPHIEMIPGAHSLPSGHVYSLSESEMAALRDFVDRNVKNGLMTPTVAPNGAQVLQVKRGWKLQVTYNCRAPHNCTVQNQYHRMSLPNMEDQAHLATYGEFVPHGHGGYHHHHHHPHHHHAPAYATFAGHHLMFAWYPVGRDVHGRVIFMPFVVTWCPHGYHHHPLPVPQYPPPQPPPPPPPPPPPPPPPPSYSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HAX9</accession>
    <name>A0A9J7HAX9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 431 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100753410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035307345.1">
        <property type="nucleotide sequence ID" value="XM_035451454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HAX9"/>
    <dbReference type="GeneID" id="100753410"/>
    <dbReference type="KEGG" id="cge:100753410"/>
    <dbReference type="OrthoDB" id="9585558at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="6">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035307345.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11333" checksum="17FE4FFD121424DB" modified="2023-06-28" version="1">MYGVFKNAVTYNDVHINFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGYSCEDHNIEEHCQSSTRHRRYIKEDGLERNPMNVISVEKPFQDMVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HC55</accession>
    <name>A0A9J7HC55_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Slc44a3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307888.1">
        <property type="nucleotide sequence ID" value="XM_035451997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HC55"/>
    <dbReference type="GeneID" id="100774225"/>
    <dbReference type="CTD" id="126969"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF13">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039923541" description="Choline transporter-like protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035307888.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="69074" checksum="F7BE80875BD34B38" modified="2023-06-28" version="1">MPLVFCQVFIMGYSVVAGAAGRLLFGYDSFGNVCGKKNSPVEGAPLSGQDMTLKKHVFFMNACDLQVKDRWLGRTALCVSRCPEKQLDTLEEIQLFADINGSSLCVYSLNSFNYTQSPNADTLCPRLPVPPSKSFPLLNRCIPQTPECYSLFASVLINDADALHRILSGIMAGRDTILGLCVFTFALSLAMLFAFRFISTLLVHIIISLVILGLLFVCGVLWWLYYDYTNDLSTELDTERENMKCMLAFAIVTTVMTAVLLVLIFTLRKRIKLTVELLQVTNKAISTCPFLLFQPLWTFAILIFFWVLWVTVLLSLGTAGTAQVIEGGQVEYKPLSGIRYMWWYHLIGLIWTSEFILACQRITIAGAMATCYFNRNQSDPPAHPILSSLSILFCYHQGTAVKGSFLITVTRIPRVILMHMYNTLREPQCGAWSRGVFRCNYCGFRCLARHLQLLNQNAYTAAAINGTDFCTSAKDAHKIMSKNTSHLMSVNCFGNFVIFLGKVLVVCFTVFGGLMAFNYNRALQVWAIPLLLVAFFAYLVAHSFLSVFETVLDILFLCFAVDLETNDGSSEKPYFMHPEFLSFITRTNNCNNARPRGHRDSLPNEEGTELRPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCP1</accession>
    <name>A0A9J7HCP1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 431-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC118239773</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309546.1">
        <property type="nucleotide sequence ID" value="XM_035453655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCP1"/>
    <dbReference type="GeneID" id="118239773"/>
    <dbReference type="KEGG" id="cge:118239773"/>
    <dbReference type="OrthoDB" id="9594108at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000187">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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            <begin position="127"/>
            <end position="154"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
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            <begin position="155"/>
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        </location>
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            <end position="210"/>
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            <end position="266"/>
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            <end position="294"/>
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            <end position="322"/>
        </location>
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            <end position="350"/>
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            <end position="378"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
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            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035309546.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="47379" checksum="4F65FA78CCCE9EC0" modified="2023-06-28" version="1">MKYKDVHIDFTWEEWTLLDTSQRNLYKDVMLETYENLNDIGYSWEDNIEEHCASSKRHDRHERRQIGENSSVYTQCDKAFENNGYLQSHERKDTEEKSYECNQCGKAFAYHSYLLIHQRRHRGEKTYECNQCGKAFSYYSTLQMHERTHTGEKPYECNQCGKAFSQQRYLQMHKRTHTGEKPYECNLCGKAFSRHSHLHMHKRTHTGEKPYECNQCGKAFSRLSNLKMHKRTHTGEKPYECNQCGKAFSQDSTLQSHKRTHTGEKPYECNQCGKAFSHQCTLQLHKRTHTGEKPHECNQCGKAFAHDSTLQSHKRTHTGEKRYECNQCGKAFARHTTLQIHKRTHTGEKPYKCNECGKAFSHQCTLQSHKRSHTGEKPYECNQCGKVFSHHSSLQIHKRTHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HER4</accession>
    <name>A0A9J7HER4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 431-like isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100752592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035309550.1">
        <property type="nucleotide sequence ID" value="XM_035453659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HER4"/>
    <dbReference type="GeneID" id="100752592"/>
    <dbReference type="OrthoDB" id="9865365at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
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        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="12">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035309550.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42718" checksum="14008FBF3D67E2E9" modified="2023-06-28" version="1">MDTSQKNLYKDVMLETYRNLNDIGYNWEDNSIEEHCASCKRHERHEGRQTAQKPSVYTQCHKAYACYSHLQRHKRSHSGEKPYECNLCGKPFANYSHLKTHLRTHTGEKPYECNQCGKAFARQSTLQIHKRTHTGEKPYECNQCGKAFAQQSTLQMHKRTHTGEKPYECNQCDKAFSHQGSLHVHERTHTGEKPYECSQCGKAFARYSQLHVHERTHTGEKPYECNQCGKTFACYSQLQMHKRTHTREKPYECNQCGKAFSNQSTLNVHKRTHTGEKPYECNECGKAFSHHGNLQIHKRRHTGEKPYECNQCGKAFSHHSNLQIHKRRHTGEKPYECNQCGKAFSHHGSLQKHKRRHTGEKPYECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J3K9</accession>
    <name>A0A9J7J3K9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronic acid decarboxylase 1</fullName>
            <ecNumber evidence="5">4.1.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-glucuronate decarboxylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Uxs1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:23917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer and homotetramer. Interacts with AKT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027242522.1">
        <property type="nucleotide sequence ID" value="XM_027386721.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J3K9"/>
    <dbReference type="GeneID" id="100763471"/>
    <dbReference type="KEGG" id="cge:100763471"/>
    <dbReference type="CTD" id="80146"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000065">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021761">
        <property type="entry name" value="UXS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11803">
        <property type="entry name" value="UXS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="UDP-glucuronate decarboxylase N-terminal" evidence="20">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="21">
        <location>
            <begin position="97"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF11803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027242522.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48154" checksum="2135854F7EBD6437" modified="2023-06-28" version="1">MVSKGLLRLVSSVNRRRMKLLLGIALLAYAASVWGNFVNMSFLLNRSIQENGELKFESKIEEIVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARVKKGRTRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JDU9</accession>
    <name>A0A9J7JDU9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Chaperonin 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Class II mMOB1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">MOB-like protein phocein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mob1 homolog 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Mps one binder kinase activator-like 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Preimplantation protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC100773141</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Binds STRN4. Interacts with DNM1 and EPS15. Interacts with nucleoside diphosphate kinase. Interacts with CTTNBP2. Interacts with CTTNBP2NL. Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homoheptamer arranged in a ring structure. 2 heptameric Hsp10 rings interact with a Hsp60 tetradecamer in the structure of a back-to-back double heptameric ring to form the symmetrical football complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">Golgi stack membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOB1/phocein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007643075.1">
        <property type="nucleotide sequence ID" value="XM_007644885.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252705.1">
        <property type="nucleotide sequence ID" value="XM_027396904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JDU9"/>
    <dbReference type="GeneID" id="100773141"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000002">
        <property type="entry name" value="MOB-like protein phocein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027252705.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29709" checksum="658F1268A4B3800C" modified="2023-06-28" version="1">MAGQAFKKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKDFYNWPDESFDEMDSTLAVQQYIQQNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JLX1</accession>
    <name>A0A9J7JLX1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Tyrosine-protein kinase receptor TYRO3</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">Tyro3</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
            <tissue evidence="35">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027277949.1">
        <property type="nucleotide sequence ID" value="XM_027422148.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100772328"/>
    <dbReference type="KEGG" id="cge:100772328"/>
    <dbReference type="CTD" id="7301"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05074">
        <property type="entry name" value="PTKc_Tyro3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000089">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000296">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000484">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000605">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000780">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000111">
        <property type="entry name" value="Tyrosine-protein kinase receptor TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF279">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR TYRO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 25 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 35" id="KW-0418">Kinase</keyword>
    <keyword evidence="26" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 25 27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18 35" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 30" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="30">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039905597" description="Tyrosine-protein kinase receptor TYRO3" evidence="30">
        <location>
            <begin position="32"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="32">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="32">
        <location>
            <begin position="129"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="33">
        <location>
            <begin position="217"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="33">
        <location>
            <begin position="315"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="31">
        <location>
            <begin position="508"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="841"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="24">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00039486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00065245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="RefSeq" id="XP_027277949.1"/>
        </source>
    </evidence>
    <sequence length="880" mass="96253" checksum="B6CFF834BEBB462F" modified="2023-06-28" version="1">MALRRSMGRPGXPPLLLAGLASLLFPESAAAGLKLMGAPVKMTVSQGQPVKINCSVEGMEDPDIHWMKDGAVVQNASQVSISISEQYWIGLLSLKSVERSDAGLYWCQVKDGAETKTSQSVWLTVEGVPFFTVEPKDVAVPPNAPFQLSCEAVGPPEPVTIFWWRGPTKVGGPAPSPSILNVTGVTQRTEFSCEAHNIKGLATSRPAVVRLQAPPAAPFNITVTTINSRNASVAWVPGADGLALLHSCTVQVARAPGDWEVLAVVVPVPPFTCLLRDLAPATNYSLRVRCANALGPSPYADWVPFQTKGLAPARAPQNLRALRTDSGLILEWEEVIPEDPGEGPLGPYKLFWVQENGTQDELIVEGTRANLTGWDPQKDLILRVCVFNAVGCGPWSQPLVVSSHDHAGRQGPPHSRASWVPVVLGVLTALITAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKDKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIERAEQPTERGSPELPCGEQLSSEAGDGSGVGAVGGIPSDCRYIFSPGDLAESPGQSEQQPESPLNETQRLLLLQQGLLPHSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JMW7</accession>
    <name>A0A9J7JMW7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18">Protein mono-ADP-ribosyltransferase PARP9 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC103164543</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18">17A/GY</strain>
            <tissue evidence="17 18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027268560.1">
        <property type="nucleotide sequence ID" value="XM_027412759.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300468.1">
        <property type="nucleotide sequence ID" value="XM_035444577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JMW7"/>
    <dbReference type="GeneID" id="103164543"/>
    <dbReference type="KEGG" id="cge:103164543"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060335">
        <property type="term" value="P:positive regulation of type II interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000010">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057049">
        <property type="entry name" value="PARP14_KH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF70">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23254">
        <property type="entry name" value="KH_PARP14_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="15">
        <location>
            <begin position="73"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="15">
        <location>
            <begin position="276"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="14">
        <location>
            <begin position="596"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027268560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035300468.1"/>
        </source>
    </evidence>
    <sequence length="828" mass="92822" checksum="5971D45B20B735B8" modified="2023-06-28" version="1">MAFYMGSETAAYTERPASSAFAEHNRWQIPIKHNVFEILKSNEDQLCKVLQNKFGCVSTLSSPRVARNSAPAQQVFRRMLTPWIELSVWKDDLTRHVVDAVVNAANEELWHGGGLAGSLVKAGGFEIQEESRRLIATYGKVPTGQIAITKAGRLPCNWIIHAVGPRWTGSQTSIDLLRAAIKNTLDYVCIQNTHIKTVAIPALSSGIFQFPLDLCTHTILETISLYFQGKQPIRYLKEIHLVSNEDRTVASFKDAAENILGKMELSPWESPGTTPSSNVMLQIGQGQTLQIVQGCIELQTTDVIVNSGFLHDLKSGSVSQSIVKQAGLEMERELDKVNLSSDYQMVLVTKGFKLSCQYVFHVAWKFEKKQQILKDAVKTCLEKCLQLDVNSISFPALGTGLIEIEKSTAAMIMVDEILAFFKMHMKKTLTVRIVIFPVDVETYRAFCAEMMKRSNELSLSSNSVLSVPQWTRGEQRGGLEAGSPAINLMGVNAEEMCEAKEWIERLLTSEEHHIIENNHILYLGKNEHDKLSQLQTASGVSISETVSPLKAMLEIRGAQADLIEAVMNVECMLCEVQGEVARKKEKSLFDLLGQWTNKEGKLDEMEKFHTYLRYPVPLTQELEDRKRQFEKCGLWVVKVEQIQNNALMAAFLEKKKMMEERMPRGPGSQRLFQQVPYQFCNVVCKVGFHRLYSTPHDPVYGAGIHFTKSLKKLADKVKKTSSTDRLIYVFEAEVLTGSFCQGNNLIITPPPLSPGALDVHDSVVDNVSNPETVVVFNGMQALPQYLWICTQDRTLLQHQMWGQDYSSGLAMVSSPPQSWLEVSYGSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JU57</accession>
    <name>A0A9J7JU57_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP-ribosylation factor GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ADP-ribosylation factor 1 GTPase-activating protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">ARF1-directed GTPase-activating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Arfgap1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. It is probably a component of the COPI coat protein complex. The interaction with TMED2 inhibits the GAP activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003503174.2">
        <property type="nucleotide sequence ID" value="XM_003503126.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275721.1">
        <property type="nucleotide sequence ID" value="XM_027419920.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JU57"/>
    <dbReference type="GeneID" id="100759225"/>
    <dbReference type="KEGG" id="cge:100759225"/>
    <dbReference type="CTD" id="55738"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000008">
        <property type="entry name" value="ADP-ribosylation factor GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="21">
        <location>
            <begin position="133"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="422"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027275721.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="59202" checksum="4081B36B4DF42A0A" modified="2023-06-28" version="1">MSPFEARRSRKLLAAGGGDSEHPVQPGNSAGPTPGGQQGPCVRLPIAAAVQTPRPLSLLLSIPRLRGSTWPLGALGRTQTGSAQPSGPGKSRWRLYTSKEDSVQRRLEARPPSLSWLIVPFWPLNTMASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQEDYEPNWSLQDKYSSRAAALFRDKVATLAEGREWSLESSPAQNWTPPQPKMLQSTAHRPSGQPQNMTASGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNNAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKTEDTSDRPFEGHSYQNSSGDNSQNSTIDHSFWETFGSSEPPKAKSPSSDSWTYADASTGRRSSDSWDVWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKATPSTATDEGWDNQNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUL5</accession>
    <name>A0A9J7JUL5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-fucose dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Hydroxysteroid 17-beta dehydrogenase 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Hsd17b14</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-fucose + NAD(+) = L-fucono-1,5-lactone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81515"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:81457"/>
            <dbReference type="EC" id="1.1.1.122"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:81516"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.122" evidence="7"/>
    <dbReference type="RefSeq" id="XP_027276414.1">
        <property type="nucleotide sequence ID" value="XM_027420613.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JUL5"/>
    <dbReference type="GeneID" id="100752644"/>
    <dbReference type="KEGG" id="cge:100752644"/>
    <dbReference type="CTD" id="51171"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047834">
        <property type="term" value="F:D-threo-aldose 1-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006706">
        <property type="term" value="P:steroid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000600">
        <property type="entry name" value="17-beta-hydroxysteroid dehydrogenase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027276414.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="28357" checksum="BB0301D0F492A8E2" modified="2023-06-28" version="1">MAAVNRYSGKVVVVTGGGRGIGAGIVRAFVDSGAQVVFCDKDEVRGRALEQELLGTVFVPCDVTQEGDLQALISETLSRFGHLDCVVNNAGYHPPAQAPEETSAQDFRQLLELNLLSTYNLTKLALPHLRKRRGNIINISSLVGTIGQSQAVTYVATKGAVTAMTKALALDESRYGVRVNCISPGNIWTPLWEELAASTSDPSATILEGTLAQPLGRMGQPAEVGAAAVFLASEATFCTGLELLVTGGAELGYGCKASRSSLVEAPILPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUU1</accession>
    <name>A0A9J7JUU1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cystatin-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100772051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003500026.2">
        <property type="nucleotide sequence ID" value="XM_003499978.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276766.2">
        <property type="nucleotide sequence ID" value="XM_027420965.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JUU1"/>
    <dbReference type="GeneID" id="100772051"/>
    <dbReference type="KEGG" id="cge:100772051"/>
    <dbReference type="OrthoDB" id="9829654at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052333">
        <property type="entry name" value="Cystatin_spermatogenesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47393:SF1">
        <property type="entry name" value="CYSTATIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47393">
        <property type="entry name" value="CYSTATIN-12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039948892" evidence="8">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="9">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027276766.2"/>
        </source>
    </evidence>
    <sequence length="128" mass="14986" checksum="7EA48FE552150099" modified="2023-06-28" version="1">MLWKVFLLVGLIVLGIHDCSFKFVEISKNDKYFGISVEYVVFHFNENQDDNFAYKFLRVRRSLHQKGDSIFLIDLEMGRTVCEKHDEDIDNCPLQKGQGERKARCTYIVESEAWITEFTILNSTCVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JYL3</accession>
    <name>A0A9J7JYL3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Microphthalmia-associated transcription factor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Mitf</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027284749.1">
        <property type="nucleotide sequence ID" value="XM_027428948.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JYL3"/>
    <dbReference type="GeneID" id="100754846"/>
    <dbReference type="KEGG" id="cge:100754846"/>
    <dbReference type="CTD" id="4286"/>
    <dbReference type="OrthoDB" id="6242697at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18926">
        <property type="entry name" value="bHLHzip_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000003">
        <property type="entry name" value="microphthalmia-associated transcription factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021802">
        <property type="entry name" value="MiT/TFE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF4">
        <property type="entry name" value="MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11851">
        <property type="entry name" value="DUF3371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027284749.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="58711" checksum="F883D047F874191F" modified="2023-06-28" version="1">MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPLSSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRHQVKQYLSTTLANKHASQVLSSPCPNQPGDHAMPPVPGSSAPNSPMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQELVQHQTDLTCTTTLDLTDGTITFTNNLGTMPENNPAYSIPRKMGSNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRSSMSAEETEHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JYY8</accession>
    <name>A0A9J7JYY8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Outer dense fiber protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Outer dense fiber of sperm tails protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Odf4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027282881.1">
        <property type="nucleotide sequence ID" value="XM_027427080.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JYY8"/>
    <dbReference type="GeneID" id="100752383"/>
    <dbReference type="KEGG" id="cge:100752383"/>
    <dbReference type="CTD" id="146852"/>
    <dbReference type="OrthoDB" id="9620006at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000074">
        <property type="entry name" value="Outer dense fiber of sperm tails 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF94">
        <property type="entry name" value="OUTER DENSE FIBER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="254"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027282881.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34793" checksum="4E21D2B0FEF04051" modified="2023-06-28" version="1">METDLTEEEIEKRSRNRRSLTEQRRNSLLPFQWRITHSSRWLSQLVASEFSLVGLLLLLVMVFSKKWLYPSKSRFHQRYSKNVTNRVYTSIHKMSTGFLYTCISRSCSSSDSEKDSFKLWTNHPFLGVANVSFTLALGLGFALTAWLHLPYLPRLQRMPFFGLIGIILSFCEVTFIFLTLLLFPVNLWIYELKKNISVPIGWSYFIGWLVLVLYFTCGVLCYLNHKNFWSLMMSSSSSINNPSSSITEREGSLMQETLMSSPEQSSSNLKHIPDPDDDDQEDNQKPASLTNYFLGPYPASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JZF3</accession>
    <name>A0A9J7JZF3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Transcription elongation factor A protein-like 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC100772892</name>
        <name evidence="5 6" type="synonym">LOC100767507</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3 4 5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4 5">17A/GY</strain>
            <tissue evidence="3 4 5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003513200.1">
        <property type="nucleotide sequence ID" value="XM_003513152.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651672.1">
        <property type="nucleotide sequence ID" value="XM_007653482.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288830.1">
        <property type="nucleotide sequence ID" value="XM_027433029.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288831.1">
        <property type="nucleotide sequence ID" value="XM_027433030.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306039.1">
        <property type="nucleotide sequence ID" value="XM_035450148.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306040.1">
        <property type="nucleotide sequence ID" value="XM_035450149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JZF3"/>
    <dbReference type="GeneID" id="100772892"/>
    <dbReference type="KEGG" id="cge:100767507"/>
    <dbReference type="KEGG" id="cge:100772892"/>
    <dbReference type="OMA" id="RINNFYW"/>
    <dbReference type="OrthoDB" id="9837766at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021156">
        <property type="entry name" value="TF_A-like/BEX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04538">
        <property type="entry name" value="BEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027288830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027288831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035306039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035306040.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22565" checksum="400C47A185CAEF5C" modified="2023-06-28" version="1">MEELRGEKEGKLEKEGKAEDEVESEDEEKSDGEEKPDKKAKPAREGKLEEGAKQDEQGQPQDEGKSENQGKSEGEGKRQGEGKHDPQAKPASEARAAEKRPAEDYVPRKAKRKTDRGTDDSPKNSQEDLQDRHVSSEEMMRECADMTRAQEELRKRQKMGGFHWMPRDAQDALVPRGQRGVRGMRGGGRSQRGLHDIPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K0F1</accession>
    <name>A0A9J7K0F1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Actin-binding LIM protein 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Ablim3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035294611.1">
        <property type="nucleotide sequence ID" value="XM_035438720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K0F1"/>
    <dbReference type="GeneID" id="100759449"/>
    <dbReference type="KEGG" id="cge:100759449"/>
    <dbReference type="CTD" id="22885"/>
    <dbReference type="OrthoDB" id="1746725at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09327">
        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09328">
        <property type="entry name" value="LIM2_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000003">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000004">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000007">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000024">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.950.10:FF:000001">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF0">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="HP" evidence="11">
        <location>
            <begin position="631"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="388"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035294611.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="79538" checksum="84D843D80DAF872C" modified="2023-06-28" version="1">MILVTDNSYNQCGSLFMDHTVPYQQSPYSPRGSSNVIQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMTSSKPIKIHGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILTGEYISKDGVPYCESDYHAQFGIKCETCDRYISGRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRTSETSISPPGSSIGSPNRVICAKVDNEILNYKDLAALPKVKSIYEVQRPDLISYEPHSRYTSDEMLERCGYGESLGTLSPYSQDIYENLDLRQRRASSPGYIDSPTYSRQGMSPTFSRSPHHYYRSGPESGRSSPYHSQLDVRSSTPTSYQAPKHFHVPAGESNIYRKPPIYKRHGDLSTATKSKTSEDISQASKYSPAYSPDPYYASESEYWTYHGSPKVPRARRFSSGGEEEDFDRSMHKLQSGIGRLILKEEMKARSSSYADPWTPPRSSTSSREALHTTGYEMSLNGSPRSHYLADSDPLISKSASLPAYRRNGLHRTPSADLFHYDSMNAVNWGMREYKIYPYELLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQVFGMTISEFERLALWKRNELKKQARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4C8</accession>
    <name>A0A9J7K4C8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LOW QUALITY PROTEIN: microtubule cross-linking factor 1 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Mtcl1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035297064.1">
        <property type="nucleotide sequence ID" value="XM_035441173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762627"/>
    <dbReference type="KEGG" id="cge:100762627"/>
    <dbReference type="CTD" id="23255"/>
    <dbReference type="OrthoDB" id="10036174at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016327">
        <property type="term" value="C:apicolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097427">
        <property type="term" value="C:microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049885">
        <property type="entry name" value="MTCL1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027882">
        <property type="entry name" value="SOGA1/2-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027881">
        <property type="entry name" value="SOGA_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="493"/>
            <end position="587"/>
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            <begin position="622"/>
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            <begin position="1255"/>
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            <begin position="1"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11365"/>
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            <dbReference type="Pfam" id="PF14818"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    <sequence length="1981" mass="217331" checksum="1D701A223DC2364C" modified="2023-06-28" version="1">METLNGPAGGGAPDAKPQPAGQHHRHHHLHPLAERRRLHRAPSPARPLLKDLHTRPAAATPSAGRAPTPAAPRSPSLAGKAPPSPGPXAAAGRLSRRSGVVPGAKDKPPRXAGARAAGGAKATPGTRRAARAGPAEPLSRVGRPAGAEPPPAAAKGRKAKRSPGTPPARAVGPPAPAARVPAVTLSVTSVAGSRISHTDSSSDLSDCASEPLSDEQRLLPAASSDAESGTGSSDREPLRGAPTQSPGARGPPPGSPEPPALLTAPPVADASLGGRSSPGGAPSGSPGPGSVEDVGGRTPPERTILGTPREPGLGEQPRLLVVAEEEELLREIEELRSENDYLKDELDELRAEMEEMRDSYLEEDGYQLQELRKELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELETVEEKRAKAEDDNESLRQQMIEVEISRQALQNELEKLKESSLKRRGSREIYKEKKTVSQDDSADLKCQLQFAKEEASLMRKKMAKLGREKDELEQELQKYKTVYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDLRVQHEREGTGRDHAPGIPTSPFGDSLESSAELRRHLQFVEEEAELLRRSISEIEDHNRRLTHELSKFKFEPHQESSGWLGDSVSKGPGASVPLQEELKSARLQIDELSGKVLKLQYENRLLLSNVQRCDLAAHLGLRAPSPRDSDAESDTGKKESDGEEGRLPQPKREGPVGGESDSEDVCEKTSGFGSGKPSEASEPCPAELLRVREDTECLATIKQEAQRLERTVERLITDTDGFIHDSGRRGSGSASPGVPGEGEGGQDEPHLLETINVKMRAFRKELQAFLEQMTRIVDGLSPLSHLTESSSFLSTVTSVSRDSPIGTLGKELGPDLQSKLRDQLEWQLSQDRGDEREGLRLRAMQRADGDPGSQGLGGQSCFNLELRGSPVLPEQSVSVEELQGQLAQAARLHQEETETYTNKIRKMEEDHLYALRWKELEMHSLALQNTLHKRTWSDEKNLLQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEAGGEDFTESEHSENAPGFAELSVQGGHQTDGTYQEDPDRGCSLLVGEHAPHSPGQISENGSRLQNAEGGPLNRQVVENQQLFRALKALLEDFRSELREDEHARLRLQQQYASDKAAWDVEWAGLKCRLEQLEEKAEKSLGELDSSVEGKGALKKEREVHQKLLADSHGLVMDLRWQIHHREKNWNREKVELLERLDSERQEWGRQKEELLWRVEQLQKENSPRRNGSFLCGQKEDNSHLFPHHGGLRAPRPVSMWPCADTESIPFEDRPLSKLKESDRCSASENLYLDTLSLDDEPEGLPPLRTCLAEEEEESRKGNLQRAVSVSCMSEFQRLMDVSPFLPEKGLPSASSKEDVTPPLSPDDLKYIEEFNSKNWDYTSPKAGTDKPPDRWADRTEVGRVGHEATTEPFSDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGVHVLHSPPAIRRVDSIVSGGEGRSRVEPEDPFPTSRARGNLADSKGGHPEPVLNRWPCTPPRHPRDYVEGSLLPLDRPVCPSLGFTSSLHNLDMSKNMSDDMKEVAFSVRNAICSGPTKPQVRDMACQTNGSRTAGTQTVQAISVGLQTEALRASGVTSSPHKCLTPKAGGGTTPVSSPSRSLRSRQVAPAIEKVQAKFERTCCSPKYGSPKLQRKPLSKADQPNSRTSPGMAQKGFSESAWARSTTTRESPVHTTINDGLSSLFNIIDHSPVGVRAGSRSRSAEPRQELGPGQETGTSSRGRSPSPLGMGSEMCREGGGESTPVRQDLSAPPGCTLPENVARILNKKLLEHALKEEKKLAAHGPFGLPSDSHTGEAGPAEPGSMEELPCSALAPSLEPCFSRPERPANRRLPSRWAPPSPTASQSQSPGDPVSLEEHGEEEPPEEKPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K945</accession>
    <name>A0A9J7K945_CRIGR</name>
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        <submittedName>
            <fullName evidence="15">PHD finger protein 21A isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Phf21a</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035302576.1">
        <property type="nucleotide sequence ID" value="XM_035446685.1"/>
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    <dbReference type="GeneID" id="100751419"/>
    <dbReference type="CTD" id="51317"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PHD_PHF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF6">
        <property type="entry name" value="PHD FINGER PROTEIN 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="537"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
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        <location>
            <begin position="688"/>
            <end position="728"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="611"/>
            <end position="649"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
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        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035302576.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="80535" checksum="91F178D7AA83B60D" modified="2023-06-28" version="1">MRHYVQQKSLSSSTLTNQKLVAQMKQDPQIFFLSNQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLSQSENKLQTAQQQPLQPLQPLQQQQQQQQQQQQQQQQQHAQQSAAPPSLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETEEKQAESRTITPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRANEEHWPKVCKIIFPCLSLPFSPFVPFSWYIGRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKELSSSISKCMEMKNTILARQKEMRSSLDKVKQLIRLIHGIDLSKPVDSEATVGALSNGPDCTPSTNTASTPAPSPSSQSCTANCNQGEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KB48</accession>
    <name>A0A9J7KB48_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ataxin-7-like protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">SAGA-associated factor 11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Atxn7l3</name>
        <name evidence="10" type="synonym">ATXN7L3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303232.1">
        <property type="nucleotide sequence ID" value="XM_035447341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KB48"/>
    <dbReference type="GeneID" id="100754412"/>
    <dbReference type="CTD" id="56970"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000118">
        <property type="entry name" value="Ataxin-7-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03047">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCA7" evidence="12">
        <location>
            <begin position="301"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SGF11-type" evidence="10">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035303232.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50478" checksum="6FCEFA276A000139" modified="2023-06-28" version="1">MMQQQCRKDGRRAAARPATLPSAPGSFVSPHPTRGRQLLKLVPTIQWGPELWALFLNPTPCCRPLCYEQSERRLHKSLQMKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKLWYLPFQNPNSPRRSKSLKHKNGFSVCTSASNTLPLLFSSSGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDSFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNTSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KCX6</accession>
    <name>A0A9J7KCX6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 30 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC103164078</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21">17A/GY</strain>
            <tissue evidence="20 21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305161.1">
        <property type="nucleotide sequence ID" value="XM_035449270.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305162.1">
        <property type="nucleotide sequence ID" value="XM_035449271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KCX6"/>
    <dbReference type="GeneID" id="103164078"/>
    <dbReference type="KEGG" id="cge:103164078"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000020">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000473">
        <property type="entry name" value="zinc finger protein 14 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001121">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000561">
        <property type="entry name" value="Zinc finger protein 30 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000338">
        <property type="entry name" value="zinc finger protein 383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002355">
        <property type="entry name" value="Zinc finger protein 623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF435">
        <property type="entry name" value="ZINC FINGER PROTEIN 59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="18">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="234"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="262"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
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            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035305161.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035305162.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="65665" checksum="7AFE4100F98C371B" modified="2023-06-28" version="1">MPSSAPRKTELLLQWTMGLCSRHPQGGSQASVVTSVAMHVSVMFSDVSIAFSQEEWESLDLAQRDLYKDVMMENYRNVASLVGCFISKPDVISLLEQGKEPWKVVRKRRRNPDLETKDETNPSPSEGSIYEVNLSQWKIMERIGNSGLKGLIFKNEWESKRKLESQEGSQEGYLRQMKVTSEKMASYQIRTSATPHPRIHFGEKPYECDDCGKAFRVRQQLTFHQRIHTGEKPYGCKQCGMAFRQTAHLSRHQRLHSGDKPYECKECGEAFTYGPDLRAHQKTHSGEKPYACKECGKAFRVRGQLTLHQRIHTGEKPYACKECGRAFRQYAHLTRHQKLNSADRLYECKECGQDFLCGSGLRAHYRLHTGEKPYECQDCGKAFRVRQQLTLHQRTHTGEKPYECSECGKTFSRGYHLILHHRTHTGEKPYECKECWKAFSRYSQLISHQSVHIGVKPYDCKECGKAFRLLSQLTQHQSIHAGEKPYTCKDCGKSFRLRQKLTLHQSIHTGEKPFECKECRKAFRLNSSLIQHLRIHSGEKPYECKECKKAFRQHSHLTHHLKIHSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3GR83</accession>
    <name>G3GR83_CRIGR</name>
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            <fullName evidence="6">1,5-anhydro-D-fructose reductase</fullName>
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            <fullName evidence="8">Aldo-keto reductase family 1 member C-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Aldo-keto reductase family 1 member E2</fullName>
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        <name evidence="17 21" type="primary">Akr1e2</name>
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        <name evidence="15" type="ORF">I79_000026</name>
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    <organism evidence="15 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16070"/>
            <dbReference type="ChEBI" id="CHEBI:16715"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.263"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.263" evidence="5"/>
    <dbReference type="EMBL" id="JH000001">
        <property type="protein sequence ID" value="EGV95095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE673021">
        <property type="protein sequence ID" value="ERE78662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007616485.1">
        <property type="nucleotide sequence ID" value="XM_007618295.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260887.1">
        <property type="nucleotide sequence ID" value="XM_027405086.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GR83"/>
    <dbReference type="SMR" id="G3GR83"/>
    <dbReference type="STRING" id="10029.G3GR83"/>
    <dbReference type="PaxDb" id="10029-XP_007608168.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002009.1">
        <property type="protein sequence ID" value="ENSCGRP00001001721.1"/>
        <property type="gene ID" value="ENSCGRG00001001588.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750439"/>
    <dbReference type="KEGG" id="cge:100750439"/>
    <dbReference type="CTD" id="83592"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153272"/>
    <dbReference type="OMA" id="AWKAMEG"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050571">
        <property type="term" value="F:1,5-anhydro-D-fructose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000030">
        <property type="entry name" value="Aldo-keto reductase family 1 member E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="13">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV95095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ERE78662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027260887.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34375" checksum="0B5A5E0CC03FC2EC" modified="2011-11-16" version="1">MQTIPVVGLGTWKASPGEVVDAVKTAINFGYRHIDCAYLYHNEGEVGMGINSKIKEGVVKREELFVVSKLWCTYHKKSLVRTACTNTLKALNLDYLDLYLIHWPMGFKPGDKDVPLNCNGLVIPSNTSFLDTWEAMEDLVTEGLVKHIGVSNFNHEQLEKLLNKPGLKFKPITNQIECHPYLNQKNLIEFCHNRNVSVTAYRPLGGSRDGAELLDDIVIRKIAKKHGKSAAQIVIRFQIQRNVIVIPKSVTPSRIRENFQVFDFELTEKDMEELLSLDKNLRLATFPLTEHHKDYPFHIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYU1</accession>
    <name>G3GYU1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17 20">Cytochrome P450 4A10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">LOC100768783</name>
        <name evidence="16" type="ORF">I79_002920</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000068">
        <property type="protein sequence ID" value="EGV94558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295597.1">
        <property type="nucleotide sequence ID" value="XM_035439706.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296420.1">
        <property type="nucleotide sequence ID" value="XM_035440529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYU1"/>
    <dbReference type="STRING" id="10029.G3GYU1"/>
    <dbReference type="PaxDb" id="10029-XP_007630370.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016123.1">
        <property type="protein sequence ID" value="ENSCGRP00001011890.1"/>
        <property type="gene ID" value="ENSCGRG00001013423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768783"/>
    <dbReference type="KEGG" id="cge:100768783"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163570"/>
    <dbReference type="OMA" id="LMLRPMH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008391">
        <property type="term" value="F:arachidonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046456">
        <property type="term" value="P:icosanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048252">
        <property type="term" value="P:lauric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20678">
        <property type="entry name" value="CYP4B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000005">
        <property type="entry name" value="cytochrome P450 4F22 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF165">
        <property type="entry name" value="CYTOCHROME P450 4A10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV94558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035295597.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="58359" checksum="09577D9123B94939" modified="2011-11-16" version="1">MSVSALSPSRFVGSISGFLQVVSVLGLLLLLLKVVQFYLHRQWLLKAFQQFPSPPFHWFLGHKQFQGDQEIEQMMKCVENFPSAFPRWFWGSKAYFTVYDPDYMKVILGRSDPKANGAYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKTMADSVRLMLDKWEQLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYKTYIQAIGNLNNLFYSRVRNIFHQNDTIYSLSSNGRMANQACQLAHDHTDGVIKLRKDQLQDEEELEKVKKKRRLDFLDILLFARMENGDSLSDKDIRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITWDHLDQMPYTTMCIKEALRLYPPVPAIVRELITPVTFPDGRSLPKGVSVTLSIYALHHNPKVWPNPEVFDPSRFASDSPRHSHSFLPFSGGARNCIGKQFAMNELKVVVALTLLRFELLPDPTRVPIPLPRLVLKSKNGIHLHLKKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3HWF2</accession>
    <name>G3HWF2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA endonuclease ANKZF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Ankyrin repeat and zinc finger domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Ankzf1</name>
        <name evidence="22" type="ORF">I79_015309</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts (via VIM motif) with VCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="19">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000831">
        <property type="protein sequence ID" value="EGW11868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007646382.1">
        <property type="nucleotide sequence ID" value="XM_007648192.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253076.1">
        <property type="nucleotide sequence ID" value="XM_027397275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HWF2"/>
    <dbReference type="STRING" id="10029.G3HWF2"/>
    <dbReference type="GlyGen" id="G3HWF2">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007614245.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001004007.1">
        <property type="protein sequence ID" value="ENSCGRP00001002888.1"/>
        <property type="gene ID" value="ENSCGRG00001003325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773729"/>
    <dbReference type="KEGG" id="cge:100773729"/>
    <dbReference type="CTD" id="55139"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005911"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000180">
        <property type="entry name" value="Ankyrin repeat and zinc finger domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041540">
        <property type="entry name" value="VATC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18716">
        <property type="entry name" value="VATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VLRF1" evidence="21">
        <location>
            <begin position="201"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="18">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="366"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="603"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGW11868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027253076.1"/>
        </source>
    </evidence>
    <sequence length="723" mass="81084" checksum="8083490C28E7A245" modified="2011-11-16" version="1">MSPAPGTALASASVSLLDLTAEAPLVRGLSLVSQAPAEALPGASRTPCPEENTSSGRKVSPCSLDISEKLFCSACDQIFENHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEKQSSTGDLSSISGSEDSDSSSKEDLPTLDEGRAEFEKPNRPRGFYPHRVLFKNAQGQFLYAYRCVLGPRQVPPEKEELLIQNLQSGGPRYSVVLMAAAGHFAGAVFQGREVVTHKTFHRYTVRAKRGTAQGLQDAQGRASRSAGANLRRYNEAMLYKDVRDLLTGPTWAKALGEAETILLRAPRSGRSLFFGGQGAPLQRDDFRLWDIPLTTRRPTFGELQRVLHKLMTLQVYDDDPREMIRFHSLETQWKPEREERKKTTDKEKTKVPSDENKALLQDEELLKQGSESQEEGGSQVELELVELTLGTLDLREFEVLPKRRRRKKKKERSQDQQCGTHVTLLQQSQEDEPFSKPDQVVTTPLDSLVDESKAPGQPELWDMLLYACRAGDIEVLKLQLATGPVDPGIMSLLNAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLTQEMEIRQATRKKEQKAARRQREQQQQKQREQEEQEQEEQRRFAALSDREKRALAAERRFAAQLGAPRPPVPDSAAVNAGRCWSCGVSLQGLVPFHYLDFSFCSTRCLRDHRSQAGRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3I7U9</accession>
    <name>G3I7U9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease HTRA2, mitochondrial</fullName>
            <ecNumber evidence="5">3.4.21.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">High temperature requirement protein A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Omi stress-regulated endoprotease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine protease 25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Serine proteinase OMI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 29" type="primary">Htra2</name>
        <name evidence="25" type="ORF">I79_019598</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="26" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.</text>
            <dbReference type="EC" id="3.4.21.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.108" evidence="5"/>
    <dbReference type="EMBL" id="JH001458">
        <property type="protein sequence ID" value="EGW11791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511177.1">
        <property type="nucleotide sequence ID" value="XM_003511129.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285235.1">
        <property type="nucleotide sequence ID" value="XM_027429434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I7U9"/>
    <dbReference type="SMR" id="G3I7U9"/>
    <dbReference type="STRING" id="10029.G3I7U9"/>
    <dbReference type="MEROPS" id="S01.278"/>
    <dbReference type="PaxDb" id="10029-XP_007625895.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000438.1">
        <property type="protein sequence ID" value="ENSCGRP00001000414.1"/>
        <property type="gene ID" value="ENSCGRG00001000338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760629"/>
    <dbReference type="KEGG" id="cge:100760629"/>
    <dbReference type="CTD" id="27429"/>
    <dbReference type="eggNOG" id="KOG1320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155108"/>
    <dbReference type="OMA" id="MDNYRDE"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035631">
        <property type="term" value="C:CD40 receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905370">
        <property type="term" value="C:serine-type endopeptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990948">
        <property type="term" value="F:ubiquitin ligase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035458">
        <property type="term" value="P:cellular response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905090">
        <property type="term" value="P:negative regulation of type 2 mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001241">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06785">
        <property type="entry name" value="cpPDZ_HtrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000145">
        <property type="entry name" value="serine protease HTRA2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000004">
        <property type="entry name" value="Serine protease HTRA2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF127">
        <property type="entry name" value="SERINE PROTEASE HTRA2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 25 29" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="24">
        <location>
            <begin position="380"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00053829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGW11791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027285235.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="47799" checksum="B53D5B55E7A39D00" modified="2011-11-16" version="1">MAALKAGRGAGWSLRAWRALGGIFWGKGPLFTPDLQALLTLGSPDPLPARVPVGVLASRACLTSGTPDLWARLAVGTAGSSAQEARRSPGPRRREWLAVAVGAGGAMLLLLWGWGRGPPAVLAAVPAPPPSSPRSQYNFIADVVEKTAPAVVYIEILDRHPFSGREVPISNGSGFVVASDGLIVTNAHVVADRRRVRVRLPSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSWFGISGSQRRYIGVMMLTLTPSILVELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEKMVQNAEDVYEAVRTQSQLAVRIRRGSETLTLYVTPEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G3I9H9</accession>
    <name>G3I9H9_CRIGR</name>
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        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
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    <gene>
        <name evidence="16 20" type="primary">LOC100763247</name>
        <name evidence="15" type="ORF">H671_7g18665</name>
        <name evidence="14" type="ORF">I79_020226</name>
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    <organism evidence="14 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001607">
        <property type="protein sequence ID" value="EGW12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE682258">
        <property type="protein sequence ID" value="ERE67457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007650382.1">
        <property type="nucleotide sequence ID" value="XM_007652192.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282592.1">
        <property type="nucleotide sequence ID" value="XM_027426791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I9H9"/>
    <dbReference type="STRING" id="10029.G3I9H9"/>
    <dbReference type="PaxDb" id="10029-XP_007628477.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010953.1">
        <property type="protein sequence ID" value="ENSCGRP00001006960.1"/>
        <property type="gene ID" value="ENSCGRG00001009436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763247"/>
    <dbReference type="KEGG" id="cge:100763247"/>
    <dbReference type="eggNOG" id="ENOG502SI5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153124"/>
    <dbReference type="OMA" id="SYTHIVC"/>
    <dbReference type="OrthoDB" id="9620769at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE67457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027282592.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35384" checksum="229512CF72BA3A11" modified="2011-11-16" version="1">MTRSNQTFPSDFLLLGLPIPPEHQHLFHALFLTMYLTTILGNLIIIILIRLGSHLHTPMYLFLSNLSFSDLCFSSVTMPTLLHNMQSQIPSITYGGCLTQLYFYMFFGDMESLLLVVMAYDRYVAICFPLHYTSIMSPKLCAILLLLLWVLTTLHAMVHTLLTARLSFCENNVILHFLCDLSDLLKLACSDTYVNELMIFISGGLTVIMPFLFIVMSYTRIVSSILKVSSTWGIYKVFSTCGSHLSVVSLFYGTIIGLYLCPSANNSTVKQTTMAMMYTVVTPMLNPFIYSLRNRDMKRALMRVTCNEKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3I9P1</accession>
    <name>G3I9P1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LRP chaperone MESD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">LDLR chaperone MESD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mesoderm development candidate 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Mesoderm development protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Mesd</name>
        <name evidence="15" type="ORF">I79_020295</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP4; the interaction promotes glycosylation of LRP4 and its cell-surface expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MESD family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001631">
        <property type="protein sequence ID" value="EGW00041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511746.1">
        <property type="nucleotide sequence ID" value="XM_003511698.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263364.1">
        <property type="nucleotide sequence ID" value="XM_027407563.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I9P1"/>
    <dbReference type="SMR" id="G3I9P1"/>
    <dbReference type="STRING" id="10029.G3I9P1"/>
    <dbReference type="GlyGen" id="G3I9P1">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007633334.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027829.1">
        <property type="protein sequence ID" value="ENSCGRP00001023583.1"/>
        <property type="gene ID" value="ENSCGRG00001021781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759548"/>
    <dbReference type="KEGG" id="cge:100759548"/>
    <dbReference type="CTD" id="23184"/>
    <dbReference type="eggNOG" id="KOG4357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000993"/>
    <dbReference type="OMA" id="QQRCADV"/>
    <dbReference type="OrthoDB" id="75833at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904395">
        <property type="term" value="P:positive regulation of skeletal muscle acetylcholine-gated channel clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000031">
        <property type="entry name" value="LDLR chaperone MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019330">
        <property type="entry name" value="MESD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600:SF2">
        <property type="entry name" value="LRP CHAPERONE MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600">
        <property type="entry name" value="MESODERM DEVELOPMENT CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10185">
        <property type="entry name" value="Mesd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732364" description="LRP chaperone MESD" evidence="14">
        <location>
            <begin position="30"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGW00041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027263364.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25124" checksum="C5D6F092F7A41809" modified="2011-11-16" version="1">MAASSWLCAVLLFLCASDLLLLPPPGACAADTPGEATPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKLDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVSQDRCADVTLEGQVYPGKGGGSKEKNKTKPEKGKKKKEGDAKPRASKEDNRAGSRREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>G3IIC0</accession>
    <name>G3IIC0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="24">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">Csk</name>
        <name evidence="28" type="ORF">I79_023588</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 24">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer (via SH3-domain). Interacts with PTPN22. Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases. Interacts with SRCIN1. Interacts with RHOH. Interacts (via SH2 domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-96'. Interacts (via SH2 domain) with PRAG1 (when phosphorylated at 'Tyr-391'); this interaction prevents translocation of CSK from the cytoplasm to the membrane leading to increased activity of CSK. Interacts with LRRK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="24"/>
    <dbReference type="EMBL" id="JH002978">
        <property type="protein sequence ID" value="EGW15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007652712.1">
        <property type="nucleotide sequence ID" value="XM_007654522.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270764.1">
        <property type="nucleotide sequence ID" value="XM_027414963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IIC0"/>
    <dbReference type="STRING" id="10029.G3IIC0"/>
    <dbReference type="PaxDb" id="10029-XP_007613380.1"/>
    <dbReference type="GeneID" id="100755922"/>
    <dbReference type="KEGG" id="cge:100755922"/>
    <dbReference type="CTD" id="1445"/>
    <dbReference type="eggNOG" id="KOG0197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3IIC0"/>
    <dbReference type="OMA" id="PTMTTHS"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05082">
        <property type="entry name" value="PTKc_Csk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09937">
        <property type="entry name" value="SH2_csk_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11769">
        <property type="entry name" value="SH3_CSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000272">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000146">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000023">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035027">
        <property type="entry name" value="Csk-like_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="11 23 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="10 24 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 23 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 21" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4 22" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="16 24" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="26">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="25">
        <location>
            <begin position="82"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="195"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EGW15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027270764.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50744" checksum="E8D3EC9357B87547" modified="2011-11-16" version="1">MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3IP76</accession>
    <name>G3IP76_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">LOC100758441</name>
        <name evidence="14" type="ORF">I79_025780</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">CHO K1 cell line</strain>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH009303">
        <property type="protein sequence ID" value="EGW15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003515990.1">
        <property type="nucleotide sequence ID" value="XM_003515942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281956.1">
        <property type="nucleotide sequence ID" value="XM_027426155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IP76"/>
    <dbReference type="STRING" id="10029.G3IP76"/>
    <dbReference type="PaxDb" id="10029-XP_007607781.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014196.1">
        <property type="protein sequence ID" value="ENSCGRP00001009976.1"/>
        <property type="gene ID" value="ENSCGRG00001011982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758441"/>
    <dbReference type="KEGG" id="cge:100758441"/>
    <dbReference type="eggNOG" id="ENOG502SI5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153124"/>
    <dbReference type="OrthoDB" id="9975554at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Olfactory receptor"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="120"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="158"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="225"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="260"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00023170"/>
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    <evidence type="ECO:0000256" key="12">
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            <dbReference type="RuleBase" id="RU363047"/>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009976.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027281956.1"/>
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    </evidence>
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</entry>
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        <name evidence="18" type="primary">LOC100763819</name>
        <name evidence="15" type="ORF">H671_8g19551</name>
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    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="ERE66283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007652587.4"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027428505.2"/>
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    <dbReference type="KEGG" id="cge:100763819"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000083">
        <property type="entry name" value="Immunodeficiency virus type I enhancer binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000933">
        <property type="entry name" value="zinc finger protein 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="521"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE66283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027284306.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="63601" checksum="80AB29064A329E36" modified="2014-09-03" version="1">MTDAAAAPDRHVGTDLQQQAQIQSAEISLLAILAAVQAVEKKTESQAVHLRSLEMRTASAEKRLADCEKTATELSSQLEGKWAVLGTLLQDYGLLQRRLENLENQMQNRNSWILRLPDSSKDEASKVSVTTEEVTGCSPEQQEGSPEDWQKELCKHVVKETHEVLGSLGTGQLESAPSVLPWIKQEEEAYEKNLRETTHAYLCSAETWLANKNRNLEGESVVQEPAWATEGRPHKEDLERRTCGDLLPVFKEKEVSSLPQGSQSQPESTEATDNGPNFIVKELSTEHEHPHHGSQPFASLQCPQSATQQVTLTRNRCAPTAPRAYTCVQCGKSFVHQSTLTTHYRTHTGEKPYKCAECEKRFGRLSTLLEHQRTHTGERPFPCAQCGRRFGRLSTLVEHRRTHTGEKPFPCTQCDKRFTRLANLTVHQSVHSGEHAFQCTQCGSCFTHKPSFLRHLRSHSQEKRFTCGQCGKSFTCRSWLVRHQGSHARSASSAYVACEKSSPSCESSASLLKGAARGKFSSEPSASLRSKDNKTSQDHKAYGRGQQLSDHGQEGLMGSLHSCLSVKMENAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I6Q7</accession>
    <name>A0A061I6Q7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AlkB homolog 4, lysine demethylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative alpha-ketoglutarate-dependent dioxygenase alkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Alkbh4</name>
        <name evidence="2" type="ORF">H671_4g12328</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KE675306">
        <property type="protein sequence ID" value="ERE75841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272006.1">
        <property type="nucleotide sequence ID" value="XM_027416205.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310792.1">
        <property type="nucleotide sequence ID" value="XM_035454901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I6Q7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009738.1">
        <property type="protein sequence ID" value="ENSCGRP00001006218.1"/>
        <property type="gene ID" value="ENSCGRG00001008366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766685"/>
    <dbReference type="KEGG" id="cge:100766685"/>
    <dbReference type="CTD" id="54784"/>
    <dbReference type="GeneTree" id="ENSGT00390000006344"/>
    <dbReference type="OrthoDB" id="442860at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070938">
        <property type="term" value="C:contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036090">
        <property type="term" value="P:cleavage furrow ingression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141137">
        <property type="term" value="P:positive regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ERE75841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027272006.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33793" checksum="D45F7C19056A7D0F" modified="2014-09-03" version="1">MAAAAAVAGAAETTRLQACGCKGIRTCLICERQRHGSPPRQISPQKKYHFLYCPDTGWAMGPEDSEFEGWAFPFPGVTLIKDFVTPEEEAEMVCMMDSDPWKLSQSGRRKQDYGPKVNFRKQKLKMAGFQGLPSFSQKVVQRMGVYPGLEDFQPVEQCNLDYSPERGSAIDPHLDDAWLWGERLVSLNLLSATVVSMSCEAPGSLLLCSALSIGPDVFDGSIVAPSRSVPCQEVEVAICVPCRSLLVLTGAARHQWTHAIHRRHIVARRVCATFRELSNEFLPGGKRQQLGQELLQAALSFQGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I8E5</accession>
    <name>A0A061I8E5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">dCTP pyrophosphatase 1</fullName>
            <ecNumber evidence="11 13">3.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Dctpp1</name>
        <name evidence="15" type="ORF">H671_3g10202</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>dCTP + H2O = dCMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="EC" id="3.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
            <location evidence="2 13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.12" evidence="11 13"/>
    <dbReference type="EMBL" id="KE673022">
        <property type="protein sequence ID" value="ERE78657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260370.1">
        <property type="nucleotide sequence ID" value="XM_027404569.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I8E5"/>
    <dbReference type="GeneID" id="100769832"/>
    <dbReference type="KEGG" id="cge:100769832"/>
    <dbReference type="CTD" id="79077"/>
    <dbReference type="OrthoDB" id="411123at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:dCTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006253">
        <property type="term" value="P:dCTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000004">
        <property type="entry name" value="dCTP pyrophosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052555">
        <property type="entry name" value="dCTP_Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46523">
        <property type="entry name" value="DCTP PYROPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46523:SF1">
        <property type="entry name" value="DCTP PYROPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE78657.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027260370.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="17">Metastasis-associated gene family, member 2</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
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    <gene>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE672361">
        <property type="protein sequence ID" value="ERE79387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003508738.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264135.1">
        <property type="nucleotide sequence ID" value="XM_027408334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I8L9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006776.1">
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        <property type="gene ID" value="ENSCGRG00001005728.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100752944"/>
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    <dbReference type="GeneTree" id="ENSGT01030000234573"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
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    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
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</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ICE4</accession>
    <name>A0A061ICE4_CRIGR</name>
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        <recommendedName>
            <fullName evidence="14">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Atp5f1a</name>
        <name evidence="18" type="ORF">H671_2g6948</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KE669054">
        <property type="protein sequence ID" value="ERE83115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027397952.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSCGRP00001010438.1"/>
        <property type="gene ID" value="ENSCGRG00001012335.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100770431"/>
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    <dbReference type="GeneTree" id="ENSGT00550000074846"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043532">
        <property type="term" value="F:angiostatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042288">
        <property type="term" value="F:MHC class I protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001937">
        <property type="term" value="P:negative regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043536">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002432">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="17">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="15">
        <location>
            <begin position="192"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="16">
        <location>
            <begin position="422"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ERE83115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027253753.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="59763" checksum="F134F0227B94DCDB" modified="2014-09-03" version="1">MLSVRVAAAVARALPRRAGLVSKNALGSSFIGARNLHASNMRLQKTGTAEVSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDSFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVISQHQSLLGNIRADGKISEQSDAKLKEIVTNFLAGFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IHN4</accession>
    <name>A0A061IHN4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Hexosyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">B3galt6</name>
        <name evidence="18" type="ORF">H671_2g6109</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-O-(beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11780"/>
            <dbReference type="Rhea" id="RHEA-COMP:12570"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:132088"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="EC" id="2.4.1.134"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:11781"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="KE668115">
        <property type="protein sequence ID" value="ERE84250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254408.1">
        <property type="nucleotide sequence ID" value="XM_027398607.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IHN4"/>
    <dbReference type="GeneID" id="100767598"/>
    <dbReference type="KEGG" id="cge:100767598"/>
    <dbReference type="CTD" id="126792"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047220">
        <property type="term" value="F:galactosylxylosylprotein 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000018">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 17 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ERE84250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027254408.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36957" checksum="C29B090D1D91848E" modified="2014-09-03" version="1">MKVLRRAWRRRVVLTLSGLAFCSTTLLYLARCASEGETPAAAGAAQPRAKAFLAVLVASAPRAVERRSAVRSTWLAQGRRGGPKDVWARFAVGTSGLGSEERRTLDLEQAQHGDLLLLPSLRDAYENLTAKVLAMLTWLDEHVDFEFVLKADDDSFARLDALLAELRAREPARRRRLYWGFFSGRGRVKPGGRWREAAWQLCDYYLPYALGGGYILSSDLVHYLRLSGEYLRAWHSEDVSLGAWLAPVDVQREHDPRFDTEYKSRGCNNQYLVTHKQSPEDMLEKQQMLLHEGRLCKQEVQLRLSYVYDWSAPPSQCCQRKEGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HX22</accession>
    <name>A0A3L7HX22_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynactin subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dynactin subunit p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">LOC100773966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. Within the complex DCTN6 forms a heterodimer with DCTN5. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003515721.3">
        <property type="nucleotide sequence ID" value="XM_003515673.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266077.1">
        <property type="nucleotide sequence ID" value="XM_027410276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HX22"/>
    <dbReference type="SMR" id="A0A3L7HX22"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025084.1">
        <property type="protein sequence ID" value="ENSCGRP00001020840.1"/>
        <property type="gene ID" value="ENSCGRG00001019871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773966"/>
    <dbReference type="KEGG" id="cge:100773966"/>
    <dbReference type="GeneTree" id="ENSGT00390000015360"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035904">
        <property type="term" value="P:aorta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003281">
        <property type="term" value="P:ventricular septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000014">
        <property type="entry name" value="dynactin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027266077.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20112" checksum="51016D27A6CA1C35" modified="2019-02-13" version="1">MELGELLYNKSEYIETASGNKVSRQSVLCGSQNIVLNGKTIVMNDCIIRGDLANVRVGRHCVVKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHVGKNCVIGRRCVLKDCCKILDNTVLPPETVVPPFTVFSGCPGLFSGELPECTQELMVDVTKSYYQKFLPLTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IEF7</accession>
    <name>A0A3L7IEF7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Formimidoyltransferase-cyclodeaminase</fullName>
            <ecNumber evidence="7">2.1.2.5</ecNumber>
            <ecNumber evidence="8">4.3.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Formiminotransferase-cyclodeaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Ftcd</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binds and promotes bundling of vimentin filaments originating from the Golgi.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the formiminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="7"/>
    <dbReference type="EC" id="4.3.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_027250070.1">
        <property type="nucleotide sequence ID" value="XM_027394269.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IEF7"/>
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        <property type="reaction ID" value="UER00555"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:formimidoyltetrahydrofolate cyclodeaminase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
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        <property type="term" value="F:microtubule binding"/>
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        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
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        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
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        <property type="entry name" value="Formiminotransferase_C_sf"/>
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    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
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        <property type="entry name" value="Formiminotransferase_N"/>
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    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
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    <dbReference type="NCBIfam" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="Methenyltetrahydrofolate cyclohydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="22">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Formiminotransferase C-terminal subdomain" evidence="21">
        <location>
            <begin position="181"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002680"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008297"/>
        </source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010825"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012998"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017787"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="SMART" id="SM01222"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009666.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027250070.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="59002" checksum="2CC9B6C2A4080BA3" modified="2019-02-13" version="1">MSQLVECVPNFSEGNDQEVIDAISRAISQTPGCVLLDVDAGPSTNRTVYTFVGQPECVVEGALNAARTAWQLIDMSKHTGEHPRMGALDVCPFIPVRDVSMVECVLCAKAFGQRLAEELNVPVYLYGEAAQTPSRQTLPAIRAGEYEALPEKLKQAEWVPDFGPSSFVPSWGATVTGARKFLIAFNINLLSTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEEACREAQELNLPVVGSQLVGLVPLKALLDAAAFYCDKENLFVLEEEHRIRLVVNRLGLDSLAPFNPKERVIEYLVPASGCEQSLMDKSLLSFVREVGARSAAPGGGSVAAAVAALGAALASMVGQMTYGRRQFDHLDSTMRRLIPPFHAASAQLIPLVDADAQAFAAYLEAIKLPKNTPEERDRRACALQEGLRQAVAVPLKLAETVSQLWPVLKELALCGNVACLSDLQVAVKALETGVFGAYFNVLINLKDMTDDAFKQKMHHRISSLLQEAKTQAALVLASLEARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LG12</accession>
    <name>A0A8C2LG12_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DCN1-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Defective in cullin neddylation protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Dcun1d4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027246681.1">
        <property type="nucleotide sequence ID" value="XM_027390880.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LG12"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002352.1">
        <property type="protein sequence ID" value="ENSCGRP00001001923.1"/>
        <property type="gene ID" value="ENSCGRG00001001891.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756000"/>
    <dbReference type="KEGG" id="cge:100756000"/>
    <dbReference type="CTD" id="23142"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000041">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000002">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF8">
        <property type="entry name" value="DCN1-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="101"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027246681.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33934" checksum="CA8D1179F3BBCDB1" modified="2022-01-19" version="1">MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDVGQDDHQTGSLRSCSSSDCFSKVMPPRKKRRPASGDDLSAKKSRHDSMYRKYESTRIKTEEEAFSSKRCLEWFYEYAGTDDVVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTALQCDTTEKLRATLDYLRSLLNDTTNFKLIYRYAFDFAREKDQRSLDINTAKCMLGLLLGKIWPLFPVFHQFLEQSKYKVINKDQWCNVLEFSRTISLDLSNYDEDGAWPVLLDEFVEWYKDKQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LKB4</accession>
    <name>A0A8C2LKB4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dpy-19 like C-mannosyltransferase 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13 14">Probable C-mannosyltransferase DPY19L1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13 14" type="primary">Dpy19l1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14">17A/GY</strain>
            <tissue evidence="13 14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027267496.1">
        <property type="nucleotide sequence ID" value="XM_027411695.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267497.1">
        <property type="nucleotide sequence ID" value="XM_027411696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LKB4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006879.1">
        <property type="protein sequence ID" value="ENSCGRP00001004572.1"/>
        <property type="gene ID" value="ENSCGRG00001005835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765722"/>
    <dbReference type="KEGG" id="cge:100765722"/>
    <dbReference type="CTD" id="23333"/>
    <dbReference type="GeneTree" id="ENSGT00530000063023"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018103">
        <property type="term" value="P:protein C-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20178">
        <property type="entry name" value="Dpy19L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047463">
        <property type="entry name" value="Dpy19L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF5">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027267496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027267497.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="84228" checksum="FFA8EA779D14F321" modified="2022-01-19" version="1">MVLQARSKHRDAASRPPRPARASPPPLSGASEVGAGEPGPERAPPSPGRRGAAGRKGPRAETAAPAPDGLAGRLAAGLRWALGLRRGRGRTWSTLLLASFAALLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIVEAPSFLNGVWMIMNDKLTEYPLVINTLKRFNLYPEVILASWYRIYTKLMDLIGIQTKICWTVTRGEGLSPIESCEGLGDPACFYVAVIFMLNGLMMALFFIYGTYLSGSRLGGLVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTHILRATKLYRGSLIALCISNVFFMLPWQFAQFVLLTQISSLFAVHVVGYIDIYKLRKIIYIHMISLVLCFVLMFGNSMLLTSYYASSLVIIWGMLAMKPQFLKMNVSELSLWVIQGGCWLCGTVTLKYLTSRIFGIADDAHIGNLLTSKFFSYKDFDTLLYTCAAEFDFMEKETPLRYTKTLLLPVVLVVFAAIVRKIISDMWGVIAKQQTHIRKHQLDHGELVYHALQLLAYTALGVLIMRLKLFLTPHMCVMASLICSRQLFGWLFGKVHPGAVVFAVLAAMSIQGSANLQTQWNIVGEFSNLPQEELIEWIRYSTKPDAVFAGAMPTMASVKLSALRPVVNHPHYEDAGLRARTKIVYSMYSRKAAEEVKRELMKLKVNYYILEESWCIRRSKPGCSMPEIWDVEDPANAGKTPLCNILVKDSKPHFTTVFQNSVYKVLEVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LL13</accession>
    <name>A0A8C2LL13_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100759774</name>
        <name evidence="16" type="synonym">Ppp2r3c</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MCM3AP/GANP, PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027275501.1">
        <property type="nucleotide sequence ID" value="XM_027419700.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LL13"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007396.1">
        <property type="protein sequence ID" value="ENSCGRP00001004874.1"/>
        <property type="gene ID" value="ENSCGRG00001006281.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cge:100752573"/>
    <dbReference type="GeneTree" id="ENSGT00940000155583"/>
    <dbReference type="OrthoDB" id="10265007at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001782">
        <property type="term" value="P:B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045579">
        <property type="term" value="P:positive regulation of B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21505">
        <property type="entry name" value="PPP2R3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000091">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PP2A regulatory subunit B'' EF-hand" evidence="12">
        <location>
            <begin position="182"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027275501.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="53389" checksum="BF0E1512E3A5661C" modified="2022-01-19" version="1">MDWKDVLRRRLASPNTDPKRKKSEQELKEEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQIPPVIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSADLDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LYM5</accession>
    <name>A0A8C2LYM5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cbp/p300-interacting transactivator 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">LOC113833819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CITED family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295123.1">
        <property type="nucleotide sequence ID" value="XM_035439232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LYM5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012443.1">
        <property type="protein sequence ID" value="ENSCGRP00001008322.1"/>
        <property type="gene ID" value="ENSCGRG00001010621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113833819"/>
    <dbReference type="KEGG" id="cge:113833819"/>
    <dbReference type="GeneTree" id="ENSGT00530000063624"/>
    <dbReference type="OrthoDB" id="8939897at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2200:FF:000001">
        <property type="entry name" value="Cbp/p300-interacting transactivator 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007576">
        <property type="entry name" value="CITED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17045:SF5">
        <property type="entry name" value="CBP_P300-INTERACTING TRANSACTIVATOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17045">
        <property type="entry name" value="MELANOCYTE SPECIFIC GENE RELATED CITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04487">
        <property type="entry name" value="CITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035295123.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="18085" checksum="89A1B69B7AAB8B3B" modified="2022-01-19" version="1">MADHLMLAEGYCLLQVPPHAHGPHAPRTLQPYASPGLDSGLRSRGAPLGPPPPPGTLAYGSFGSSASFQPFPVAQPPGAGSAHLQPASTPSPGRIPAPPGTAGGPSPLQAAPGAASPLPPPPSLGCMDAELIDEEALKSLELELGLHRVRELPELFLGQSEFDCFSDLGSAPPAGSVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M7J3</accession>
    <name>A0A8C2M7J3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Craniofacial development protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Bucentaur</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Cfdp1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May play a role during embryogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003510212.1">
        <property type="nucleotide sequence ID" value="XM_003510164.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261852.1">
        <property type="nucleotide sequence ID" value="XM_027406051.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M7J3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018812.1">
        <property type="protein sequence ID" value="ENSCGRP00001014575.1"/>
        <property type="gene ID" value="ENSCGRG00001015423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768565"/>
    <dbReference type="KEGG" id="cge:100768565"/>
    <dbReference type="CTD" id="10428"/>
    <dbReference type="GeneTree" id="ENSGT00390000018141"/>
    <dbReference type="OMA" id="LDWAAYV"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044346">
        <property type="term" value="P:fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000270">
        <property type="term" value="P:negative regulation of fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="215"/>
            <end position="296"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="25"/>
            <end position="43"/>
        </location>
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            <begin position="121"/>
            <end position="131"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00019033"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014575.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027261852.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33020" checksum="E7D280D738DCECF1" modified="2022-01-19" version="1">MEEFDSEDFSTSDEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQAEKTKGKRRKAQDIPARKRKQSSLLLEDEEEDGKEESGGSGSEEDEEEQEGGLGSENARKKKEDELWASFLNDVGPKSKAASSSQVKAVEENEETSSNKLLVKADELEKPKESEKVKITKVFDFAGEEVRVTKEVDAASKEAKSFLKQNEKEKPQAVVTSAAAALPAGSGIKRSSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M7V8</accession>
    <name>A0A8C2M7V8_CRIGR</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="16 19" type="primary">LOC100765057</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_035439792.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313678.1">
        <property type="nucleotide sequence ID" value="XM_035457787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M7V8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018946.1">
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        <property type="gene ID" value="ENSCGRG00001015523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765057"/>
    <dbReference type="OMA" id="RMLVFAE"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008071">
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        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF108">
        <property type="entry name" value="CYTOCHROME P450 CYP2J9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="EP450ICYP2J"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014708.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035295683.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3 6 7">Integrator complex subunit 6</fullName>
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    <organism evidence="3 4">
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
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            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6 7">17A/GY</strain>
            <tissue evidence="6 7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007618689.2">
        <property type="nucleotide sequence ID" value="XM_007620499.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007618695.2">
        <property type="nucleotide sequence ID" value="XM_007620505.4"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027390363.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246165.1">
        <property type="nucleotide sequence ID" value="XM_027390364.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MCE7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020965.1">
        <property type="protein sequence ID" value="ENSCGRP00001016721.1"/>
        <property type="gene ID" value="ENSCGRG00001016976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761628"/>
    <dbReference type="KEGG" id="cge:100761628"/>
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    <dbReference type="GeneTree" id="ENSGT00390000016655"/>
    <dbReference type="OrthoDB" id="9449012at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160232">
        <property type="term" value="C:INTAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
        <property type="term" value="P:RNA polymerase II transcription initiation surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000010">
        <property type="entry name" value="Integrator complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057413">
        <property type="entry name" value="Beta-barrel_INTS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029307">
        <property type="entry name" value="INT_SG_DDX_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051113">
        <property type="entry name" value="Integrator_subunit6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957">
        <property type="entry name" value="DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957:SF23">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25462">
        <property type="entry name" value="Beta-barrel_INTS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15300">
        <property type="entry name" value="INT_SG_DDX_CT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027246164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027246165.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="99748" checksum="38E006FB7483E69D" modified="2022-01-19" version="1">MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYNELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAHRKGFQQVLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRKFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCASPLLRGRRQSPAVNSHIGGKGPPAPMTQAQPGLIKPLPLHKEATNDSAVDDVVENHVADQLSSDMTPNAMDTEFLTSPTNLLEPSTNHTEALGHEHLGNNDLTVGGFLENHDEPRNKEQSAEENIPASSLSKVKKPVHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MM68</accession>
    <name>A0A8C2MM68_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine amidotransferase like class 1 domain containing 3A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Gatd3</name>
        <name evidence="7" type="synonym">Gatd3a</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007639540.1">
        <property type="nucleotide sequence ID" value="XM_007641350.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250149.1">
        <property type="nucleotide sequence ID" value="XM_027394348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MM68"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025158.1">
        <property type="protein sequence ID" value="ENSCGRP00001020914.1"/>
        <property type="gene ID" value="ENSCGRG00001019921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762424"/>
    <dbReference type="KEGG" id="cge:100762424"/>
    <dbReference type="CTD" id="8209"/>
    <dbReference type="OMA" id="AQVQCFA"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03133">
        <property type="entry name" value="GATase1_ES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000035">
        <property type="entry name" value="ES1 protein homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008747">
        <property type="entry name" value="PRK11780.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224">
        <property type="entry name" value="ES1 PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF9">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE-LIKE CLASS 1 DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027250149.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="27848" checksum="9FDF935E5EA38E61" modified="2022-01-19" version="1">MAAVRALVAPRLVSALAPLSGRHHAPSQRAALHGSAPRPGARVALVLSGCGVYDGTEIHEASAVLVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSESESRNVLAESARIARGKITNLAQLNVANHDAAIFPGGFGAAKNLSTFAVDGKDCKVNKEVERVLKEFHGAKKPIGLCCIAPVLAAKVIKGVEVTVGHEQEEGGKWPYAGTAEAIKALGAKHCVKGVTEAHVDQKNKVVTTPAFMCETALHHIHDGIGAMVKKVLELAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MM97</accession>
    <name>A0A8C2MM97_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100773851</name>
        <name evidence="20" type="synonym">LOC100752358</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035298970.1">
        <property type="nucleotide sequence ID" value="XM_035443079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MM97"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022000.1">
        <property type="protein sequence ID" value="ENSCGRP00001017756.1"/>
        <property type="gene ID" value="ENSCGRG00001017711.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20665">
        <property type="entry name" value="CYP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF384">
        <property type="entry name" value="CYTOCHROME P450 2C29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678930" description="unspecific monooxygenase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035298970.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48832" checksum="EE214B90D23795CE" modified="2022-01-19" version="1">MDPVVVLVFMLTCLVLLSFWRQSSERRNLPPGPTPLPLIGNFLQIDVKNISQSLTKFSKVYGPVFTLYLGMKPTVVLHGYEAVKEALIDHGEMFAGRGSFPMAERLNKGLGIIFSNGSRWKETRCFTVMTLRNLGMGKRSIEDRVQEEAQCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQNRFDYKDKYFLDFLKKLNENFRILSSPWLQSIHNQQSELSLENLTITVSDLFAAGTETTSTMLRYALLLLLKHPHVTAKVQEEIDQVVGRDRSPSMQDRSHMPYTDDTVHEVQRVIKLVPTNMPHAVTNDIKFRDYYIPKGTMVITSLTSVLLDSKEFPNPEVFDPGHFLDKDGNFKKSDYFVPFSIGKRMCAGEGLAHMELFLFLTTILQNFKLKSLVQPKDIDTTPALNGFGSLPPPYKLCFIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MNK3</accession>
    <name>A0A8C2MNK3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sorting nexin 20</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Sorting nexin-20 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Snx20</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027261338.1">
        <property type="nucleotide sequence ID" value="XM_027405537.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MNK3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025715.1">
        <property type="protein sequence ID" value="ENSCGRP00001021471.1"/>
        <property type="gene ID" value="ENSCGRG00001020312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757776"/>
    <dbReference type="KEGG" id="cge:100757776"/>
    <dbReference type="CTD" id="124460"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000025">
        <property type="entry name" value="Sorting nexin 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039937">
        <property type="entry name" value="SNX20/SNX21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20939">
        <property type="entry name" value="SORTING NEXIN 20, 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20939:SF1">
        <property type="entry name" value="SORTING NEXIN-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="73"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027261338.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36070" checksum="DA3A7313D32806A7" modified="2022-01-19" version="1">MASLEHPGSPGWTGPINQSTPRTRQEALPSGPDLPCPGAEHLETLDSPSSNSSMTTRELQEHWQKEKSRWRHVKLLFEIASARIEERRVSKFVMYQVVVIQTGSFDSDKAVVERRYSDFERLQKALLKRFGPELEDVAFPRKRLTGNLSAETICERRLELRDYLRLLYAVRAVRRSREFADFLTRPELSEAFGCLRAGQYARALDVLGRVVPLQEKLTAHCPSATVPALCAMLVCLRDLERPEEAFAVGERALQRLRARESHRYYAPLLDAMVRLAYALGKDFASLQSRLDDSQLRRPTHRGFTLKELTVREYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MPF4</accession>
    <name>A0A8C2MPF4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tripartite motif-containing 10</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Tripartite motif-containing protein 10 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Trim10</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the TRIM/RBCC family.</text>
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        <property type="nucleotide sequence ID" value="XM_027388590.2"/>
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    <dbReference type="KEGG" id="cge:100754326"/>
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        <property type="entry name" value="Znf_RING_CS"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
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    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="60"/>
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            <end position="134"/>
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            <dbReference type="Proteomes" id="UP000694386"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MTM4</accession>
    <name>A0A8C2MTM4_CRIGR</name>
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        <submittedName>
            <fullName evidence="8">Transmembrane and ubiquitin-like domain containing 2</fullName>
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        <submittedName>
            <fullName evidence="11">Transmembrane and ubiquitin-like domain-containing protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Tmub2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027427963.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027438035.2"/>
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    <dbReference type="Ensembl" id="ENSCGRT00001024518.1">
        <property type="protein sequence ID" value="ENSCGRP00001020274.1"/>
        <property type="gene ID" value="ENSCGRG00001019475.1"/>
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    <dbReference type="KEGG" id="cge:100754122"/>
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    <dbReference type="OMA" id="MGNLMIP"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ubl_TMUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TMUB1/2"/>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557">
        <property type="entry name" value="PROTEIN C7ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557:SF4">
        <property type="entry name" value="TRANSMEMBRANE AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="172"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027283764.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="33914" checksum="C5BD5DEF09F3B54C" modified="2022-01-19" version="1">MISRHLQNNLMSVDPVSSQTMELSDVTLIEGVGNEVMVVAGVLVLTLALVLAWLSTYVADSSNNQLLGTIVSAGDPSVLHLGHVDQLVSQGAPEPTELPHPSEGTDEKAEETSDTGGDSTGEPGARGDTEPSLEHLLDIQGLPKRQAGLESPPEAPLGLDDSTCLSPSPSLINVRLKFLNDTEELAVARPEDTVGTLKSKYFPGQESQMKLIYQGRLLQDPARTLSSLNITNNCVIHCHRSPPGAAVSGSSGSLTPSATEPSSLGVNVGSLMVPVFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N237</accession>
    <name>A0A8C2N237_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium channel regulatory subunit beta-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Scn4b</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1. Modulates the activity of SCN2A/Nav1.2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">A voltage-gated sodium (Nav) channel consists of an ion-conducting pore-forming alpha subunit functional on its own that is regulated by one or more beta subunits. The beta subunit SCN4B is disulfide-linked to the pore-forming alpha subunit. Interacts with SCN1A; regulatory subunit of SCN1A/Nav1.1. Interacts with SCN2A; regulatory subunit of SCN2A/Nav1.2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003515321.1">
        <property type="nucleotide sequence ID" value="XM_003515273.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267807.1">
        <property type="nucleotide sequence ID" value="XM_027412006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N237"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029875.1">
        <property type="protein sequence ID" value="ENSCGRP00001025629.1"/>
        <property type="gene ID" value="ENSCGRG00001023168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767153"/>
    <dbReference type="KEGG" id="cge:100767153"/>
    <dbReference type="CTD" id="6330"/>
    <dbReference type="GeneTree" id="ENSGT01030000234556"/>
    <dbReference type="OMA" id="HQATIIL"/>
    <dbReference type="OrthoDB" id="8778219at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086006">
        <property type="term" value="F:voltage-gated sodium channel activity involved in cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086016">
        <property type="term" value="P:AV node cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086002">
        <property type="term" value="P:cardiac muscle cell action potential involved in contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010765">
        <property type="term" value="P:positive regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001260">
        <property type="entry name" value="Sodium channel subunit beta-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF14">
        <property type="entry name" value="SODIUM CHANNEL SUBUNIT BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="25" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679093" description="Sodium channel regulatory subunit beta-4" evidence="20">
        <location>
            <begin position="31"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027267807.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25147" checksum="5A2AB1D5141F5B4E" modified="2022-01-19" version="1">MSRAGDRGKTLARWLGTGLLGLFLLPMSLSLEVSVGKATTIYAINGSAILLPCTFSSCFGFENLYFRWSYNNSDTYKILIDGIVKNEKSDPKVRVKDDDRITLEGSTKEKMNNISILLSDLEFSDTGKYTCFVRNPKEKDLNNSATIFLQVVDKLEEVDNTVTLIILAVVGGVIGLLVSILLLKKLITFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N2A1</accession>
    <name>A0A8C2N2A1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-alpha-acetyltransferase 50</fullName>
            <ecNumber evidence="8">2.3.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">N-epsilon-acetyltransferase 50</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">NatE catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Naa50</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the N-terminal acetyltransferase E (NatE) complex at least composed of NAA10, NAA15 and NAA50. Interacts with NAA10. Interacts with NAA15. Predominantly interacts with NAA15 in the N-terminal acetyltransferase A complex (NatA complex); the interactions reduce the acetylation activity of the NatA complex. Component of the N-terminal acetyltransferase E (NatE)/HYPK complex at least composed of NAA10, NAA15, NAA50 and HYPK. Within the complex interacts with NAA15. Its capacity to interact with the NatA complex is reduced by HYPK. Interacts with NAA35.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="8"/>
    <dbReference type="RefSeq" id="XP_035300434.1">
        <property type="nucleotide sequence ID" value="XM_035444543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N2A1"/>
    <dbReference type="SMR" id="A0A8C2N2A1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031650.1">
        <property type="protein sequence ID" value="ENSCGRP00001027403.1"/>
        <property type="gene ID" value="ENSCGRG00001024422.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773295"/>
    <dbReference type="CTD" id="80218"/>
    <dbReference type="GeneTree" id="ENSGT00390000009110"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071962">
        <property type="term" value="P:mitotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000078">
        <property type="entry name" value="N-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF41">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035300434.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19414" checksum="153A8021B745347C" modified="2022-01-19" version="1">MKGSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEKDGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKNLKVPSGQNAETQKTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N350</accession>
    <name>A0A8C2N350_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Desmoplakin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Dsp</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Interacts with COL17A1 (via cytoplasmic region). Interacts with DSC2. Interacts with PKP1. Interacts with PKP2. Interacts weakly with TMEM65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the plakin or cytolinker family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027266183.1">
        <property type="nucleotide sequence ID" value="XM_027410382.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001028508.1">
        <property type="protein sequence ID" value="ENSCGRP00001024262.1"/>
        <property type="gene ID" value="ENSCGRG00001022227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767947"/>
    <dbReference type="KEGG" id="cge:100767947"/>
    <dbReference type="CTD" id="1832"/>
    <dbReference type="GeneTree" id="ENSGT00940000154843"/>
    <dbReference type="OrthoDB" id="8938928at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001533">
        <property type="term" value="C:cornified envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086073">
        <property type="term" value="P:bundle of His cell-Purkinje myocyte adhesion involved in cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002934">
        <property type="term" value="P:desmosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090136">
        <property type="term" value="P:epithelial cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098911">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003223">
        <property type="term" value="P:ventricular compact myocardium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000125">
        <property type="entry name" value="Desmoplakin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000123">
        <property type="entry name" value="Desmoplakin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000102">
        <property type="entry name" value="Desmoplakin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.780:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000002">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000010">
        <property type="entry name" value="plectin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041573">
        <property type="entry name" value="Desmoplakin_Spectrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF26">
        <property type="entry name" value="DESMOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00681">
        <property type="entry name" value="Plectin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18373">
        <property type="entry name" value="Spectrin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21019">
        <property type="entry name" value="Spectrin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="467"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2819"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1036"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1315"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1397"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1475"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="2832"/>
            <end position="2855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="2864"/>
            <end position="2880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027266183.1"/>
        </source>
    </evidence>
    <sequence length="2880" mass="332368" checksum="03E3A5E4EB80981A" modified="2022-01-19" version="1">MSCNGGSHPRINTLGRMTRAESGPDLRYEMTCGGVGGGGGGGGGGTSRMYYSRRCTVNDQNSDGYCQTGTMSRHQNQNTIQELLQNCADCLMRAELIAQPELKYGDGIQLARSRELDECFAQANDQMEITDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKRLTGECLGWMRQQRAEMELIAWGVDSGAVEQHINSHRSIHNAIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIEDLELHYQDFIKNSQGSEMFGDDDKRRMQSQFTDAQKHYQTLVIQLPGHPQHQTVTKTEITHVGSCQDVNHNKVIETNRENDKQETWLLMELQKIRRQMEHCEGRMTLKNLLLTDQGSTHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEIFGLFQKLENINGVTDGYLNSLCSIRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKSDLNLKKSLLATMKTELQKAQQIHSQSSQQYPLYDLDLGKFNEKVMQLTDRWQKIDKQIDFRLWDLEKQIKQLRNYRDNYQSFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHNEISGKRDKSEEVHKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMVQSPSGVILQEAADIHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLVSLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKTVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGARKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVIQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQDEAKRRWEYENELSKVRNSYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEVKRLKNTLAQTTDNLRRVEENVQQQKATGSEMSQRKQQLEIELRQVTQMRTEEGLRYKQSLDDAAKTIQDKNKEIERLKQLVEKETNERKCLEDENSKLQRAQYDLQKANNSATETISKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQSSLKDLQLQKQKVEEELNRLKRSASDDSSKRKMLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSLDVEALRRQLVQEQENVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATISELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKSQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKATLEAESRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRVEERCRRKLEDSTRETQSQLETERCRHQREIDKLRQRPYGSHRETQTEYEWTVDSSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGAIAGASASPKEKYSLVEAKRKKFITPESTVMLLEAQAATGGIIDPHRNEKLTVDNAIARDLIDFDDRQQIYTAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQLASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPITKKKVSYMQLRERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDMAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGNSSGLGGGVNDDVFSSSRHESVSKISTISSVRNLTIRSSSLSDPLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGLIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDISSYAKILTCPKTKLKISYKDAMNRSMVEDITGLRLLEAASVSSKGLPSPYNMSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSSYSYSYSFSSSSIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N6V3</accession>
    <name>A0A8C2N6V3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Costars family protein ABRACL</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ABRA C-terminal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Abracl</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the costars family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003496586.1">
        <property type="nucleotide sequence ID" value="XM_003496538.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257762.1">
        <property type="nucleotide sequence ID" value="XM_027401961.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N6V3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031954.1">
        <property type="protein sequence ID" value="ENSCGRP00001027706.1"/>
        <property type="gene ID" value="ENSCGRG00001024638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769731"/>
    <dbReference type="KEGG" id="cge:100769731"/>
    <dbReference type="CTD" id="58527"/>
    <dbReference type="OMA" id="QRVHDNV"/>
    <dbReference type="OrthoDB" id="9871914at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032970">
        <property type="term" value="P:regulation of actin filament-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1540:FF:000002">
        <property type="entry name" value="costars family protein ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044302">
        <property type="entry name" value="Costars"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334:SF1">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027257762.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9046" checksum="A2B95E63AD4E5F82" modified="2022-01-19" version="1">MNVDHEVNLLVEEIHRLGSKNADGKLSVKFGVLFQDDRCANLFEALVGTLKAAKRRKIVTYTGELLLQGVHDDVDIVLLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QJU5</accession>
    <name>A0A8C2QJU5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ankyrin repeat domain-containing protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Ankrd54</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL and LASP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027259781.1">
        <property type="nucleotide sequence ID" value="XM_027403980.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316981.1">
        <property type="nucleotide sequence ID" value="XM_035461090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QJU5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021250.1">
        <property type="protein sequence ID" value="ENSCGRP00001017006.1"/>
        <property type="gene ID" value="ENSCGRG00001017165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756181"/>
    <dbReference type="KEGG" id="cge:100756181"/>
    <dbReference type="CTD" id="129138"/>
    <dbReference type="GeneTree" id="ENSGT00940000157805"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045648">
        <property type="term" value="P:positive regulation of erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat domain-containing protein 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000162">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24197:SF44">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24197">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027259781.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="32436" checksum="4EE45BA6F22F24EF" modified="2022-01-19" version="1">MAATGGVADDESRSGRSSSDGECAVAPEPLAEAGGLFSFADLGAALGGGAGLPGRAAGRAQSPLRYLQVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGTDPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQQDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHSQCLEAVRLEVKQIIHMLREYLERLGRHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QPH6</accession>
    <name>A0A8C2QPH6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Depdc7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEPDC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003497480.1">
        <property type="nucleotide sequence ID" value="XM_003497432.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278134.1">
        <property type="nucleotide sequence ID" value="XM_027422333.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QPH6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030957.1">
        <property type="protein sequence ID" value="ENSCGRP00001026711.1"/>
        <property type="gene ID" value="ENSCGRG00001023950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771553"/>
    <dbReference type="KEGG" id="cge:100771553"/>
    <dbReference type="CTD" id="91614"/>
    <dbReference type="GeneTree" id="ENSGT00950000182976"/>
    <dbReference type="OMA" id="YCTRVSA"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04446">
        <property type="entry name" value="DEP_DEPDC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04405">
        <property type="entry name" value="RhoGAP_BRCC3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF9">
        <property type="entry name" value="DEP DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027278134.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58316" checksum="1299294C524959BB" modified="2022-01-19" version="1">MATVREKAAALNLSALHSPAQKPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHHLKRHNDCFIGSEAVDVIYSHLTQNKFFGDVDIPRAKVVRVCQALMDYKVFEAVPTRVFGKDKKPPFEDSSCSLYRFTTIPGQNSQSGNENKVDSPSRYSDTLFQSPEIKSDSLEDLWENLSLKPANSPHINISTRLSPQVINEVWQEETIGRLLQLVDLPFLDSLLKQQEVVPKVPRSKKQPDMVNTSNYLDRGILRAYGDSQEDEWVSAAIDCLEYLPDHMVVDISRNFPEQPDRTDLVKELLFDAIGKYYSTREPLLNHLCDVHNGIAELLVNGKTEIALEATQLFLKLLDSQNREEFRRLLYFMAVAAHPSEFKLQEESDNRMVVKRVFSKAVVNNKNLSKGKTDLLVLFLMDHQKDVFKIPATLHKIVSVKLLAIQKGRDPNKDTGYIYCQRIDESDYSGSKQKKTKEELLNLLKTIDEDSKLSAKEKKKLLGQFHKCHPDIFTEYFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZ37</accession>
    <name>A0A9J7EZ37_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Nuclear receptor subfamily 1 group D member 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Nr1d2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027245189.1">
        <property type="nucleotide sequence ID" value="XM_027389388.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EZ37"/>
    <dbReference type="GeneID" id="100768895"/>
    <dbReference type="KEGG" id="cge:100768895"/>
    <dbReference type="CTD" id="9975"/>
    <dbReference type="OrthoDB" id="7634782at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07166">
        <property type="entry name" value="NR_DBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06940">
        <property type="entry name" value="NR_LBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000016">
        <property type="entry name" value="Nuclear receptor subfamily 1 group D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000013">
        <property type="entry name" value="Nuclear receptor subfamily 1 group D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF112">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18 20 25" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="17 20" id="KW-0804">Transcription</keyword>
    <keyword evidence="13 20" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="22">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="23">
        <location>
            <begin position="368"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027245189.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64383" checksum="449FAC852462BBAB" modified="2023-06-28" version="1">MELNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDANGNPKNSDISSIDGVLKSDHTDCPVKTGKPGAPGMTKSHSGMTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNTQFNGHLQNDTLAERHEQSTLSAQEQLRPKPQLEQENLKSSPPSSDFAKEEVIGMVTRAHKDTFLYNQEHRETSAESMPSQRGERIPRNVEQYNLNHDHCSSGLHSHFTCSESQQHLSGQYKGRNIMHYPNGHAICIANGHCVNFSSAYTQRVCDRVPIDGFCQNENKNSFLCNTGGRMHLVCPMSKSPYVDPQKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLSSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F7T7</accession>
    <name>A0A9J7F7T7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copine-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Copine V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Cpne5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copine family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027250246.1">
        <property type="nucleotide sequence ID" value="XM_027394445.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F7T7"/>
    <dbReference type="GeneID" id="100750402"/>
    <dbReference type="KEGG" id="cge:100750402"/>
    <dbReference type="CTD" id="57699"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000117">
        <property type="entry name" value="copine-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000013">
        <property type="entry name" value="copine-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF51">
        <property type="entry name" value="COPINE-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="178"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="345"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027250246.1"/>
        </source>
    </evidence>
    <sequence length="610" mass="67501" checksum="5D15BE541D0DB335" modified="2023-06-28" version="1">MEQPEDMASLSEFDSLAGSIPATKVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWREFGRTEVIDNTLNPDFVRKFIVDYFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLGEIVGSSGSRLEKPLTIGAFSLNSRTGKPMPAVSNGSGLWMESFRTTDPEASGGVPGKKCGSIILSAEELSNCRDVATMQFCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELARGQSQFNIYEVINPKKKMKKKKYVNSGTVTLLSFAVESESTFLDYIKGGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYALALTAVGEIIQHYDSDKMFPALGFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYHSSLRTVQLYGPTNFAPVVTHVARNAATVQDGSQYSVLLIITDGVISDMAQTKEAIVNAAKLPMSIIIVGVGQAEFDAMVELDGDDVRISSRGKLAERDIVQFVPFRDYVDRTGNHVLSMARLARDVLAEIPDQLVSYMKAQGIRPRPPPAAPPQSPPQSPTHSPPGSPLHTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F9P1</accession>
    <name>A0A9J7F9P1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fucose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Fpgt</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027250994.1">
        <property type="nucleotide sequence ID" value="XM_027395193.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F9P1"/>
    <dbReference type="GeneID" id="100769105"/>
    <dbReference type="KEGG" id="cge:100769105"/>
    <dbReference type="CTD" id="8790"/>
    <dbReference type="OrthoDB" id="10062280at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042350">
        <property type="term" value="P:GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012120">
        <property type="entry name" value="Fucose-1-phosphate_GuaTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15045">
        <property type="entry name" value="FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15045:SF1">
        <property type="entry name" value="FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036640">
        <property type="entry name" value="FPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="4">
        <location>
            <begin position="134"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027250994.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="69872" checksum="7BEE492E33C2E4A3" modified="2023-06-28" version="1">MCERRTLPRETRMRTGAGRGDVTARQRAGTGAWRGLPEAGTMASLREASLRKLRRFSEMRGKPVATGKFWDVVVITAADEKQELAYKQQLSEKLKRKELPLGVNYHVFTDPPGTKIGNGGSTLCSLQCLESLYGDKWNSFTVLLIHSGGYSQRLPNASALGKIFTALPLGEPIYQMLDLKLAMYMDFPSRMKPGVLVTCADDIELYSIGDSESIAFEQPGFTALAHPSSLAVGTTHGVFVLDSAGSLQHGDLEYRQCHRFLHKPSIENMHHFNAVHRLGSFGQQDLSGGDTTCHPLHSEYVYTDSLFYMDHKSAKKLLDFYESVGPLNCEIDAYGDFLQALGPGATAEYTKNTSHVTKEESHLLDMRQKIFHLLKGTPLNVVVLNNSRFYHIGTMEEYLLHFTSNGSLQAELGLQSVAFSVFPNVPEDSHEKPCVIHSILNSGCCVAPGSVVEYSRLGPEVSISENCIISGSVIEKAVLPPCSFVCSLSVEINGHLEYSTMVFGMEDNLKNSVKTISDIKMLQFFGVCFLTCLDIWNLKAMEELFSGSKTQLSLWSARIFPVCSSLSESVAASLGMLNAIRNHSPFSLNNFKLLSIQEMLLCKDVGDMLAYREQLFLEISSKRKQSDSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FBT6</accession>
    <name>A0A9J7FBT6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kazrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC100773492</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the kazrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255763.1">
        <property type="nucleotide sequence ID" value="XM_027399962.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FBT6"/>
    <dbReference type="GeneID" id="100773492"/>
    <dbReference type="KEGG" id="cge:100773492"/>
    <dbReference type="OrthoDB" id="6430345at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09564">
        <property type="entry name" value="SAM_kazrin_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09567">
        <property type="entry name" value="SAM_kazrin_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09570">
        <property type="entry name" value="SAM_kazrin_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000048">
        <property type="entry name" value="kazrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000005">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000007">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037614">
        <property type="entry name" value="Kazrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059089">
        <property type="entry name" value="Kazrin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037613">
        <property type="entry name" value="Kazrin_SAM_rpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037615">
        <property type="entry name" value="Kazrin_SAM_rpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037616">
        <property type="entry name" value="Kazrin_SAM_rpt_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776:SF1">
        <property type="entry name" value="KAZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776">
        <property type="entry name" value="KAZRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25986">
        <property type="entry name" value="Kazrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0417">Keratinization</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="451"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="537"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="617"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="295"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="690"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="122"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027255763.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="86866" checksum="401902E89CB0D5F4" modified="2023-06-28" version="1">MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGGPGSGPGAATSASASAVTVADSAAATMENHQHSAQVLLREEVLQLQEEVLLLRQMKEVLAKDLEESQGGKCSEALSATELRVQLVQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHAAALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKSLHSPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRHSLSLSEGEEQMDRLQHVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACAENVKSGKVLLSLSDEDLELGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKASDLDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRDLEKHLNISKKFHQVSILLGIELLYQVNFSREVLQERRARCETQNTDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMSTVFHPANSTGIRESERFGTPPGRASSVTRAGKEESSGNSKYRASRLPLGKIGRGFSSKEPDFHDDYGSLENEDCAEDDLQGRPEQCRLEGYNSLEVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FC52</accession>
    <name>A0A9J7FC52_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bromodomain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Brd8</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027256517.1">
        <property type="nucleotide sequence ID" value="XM_027400716.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FC52"/>
    <dbReference type="GeneID" id="100774001"/>
    <dbReference type="KEGG" id="cge:100774001"/>
    <dbReference type="CTD" id="10902"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05507">
        <property type="entry name" value="Bromo_brd8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000016">
        <property type="entry name" value="bromodomain-containing protein 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037966">
        <property type="entry name" value="Brd8_Bromo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF13">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 14" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Bromo" evidence="17">
        <location>
            <begin position="797"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="183"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="585"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="904"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027256517.1"/>
        </source>
    </evidence>
    <sequence length="951" mass="102797" checksum="55A0F1FFF2952C0C" modified="2023-06-28" version="1">MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRAAELIEAGHMDNRLDELCSDIAMKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMSVASGHLNSTGVLLEVGGVLPMIHGGEIQPTTSTVAASPAASGAPTLSRLLEAGPTQFTTPLPSFTTVASEPPVKLVPPPVESVSQATIVMMPPLSTPSSAPAVSTPESVAPVNQPDTCVPLEAVGDPHTVTVSMDSSEISMIINSIKEECFRSGVAEAPGGSKAPSIDGKEDLDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEEAENKGIHELVDIRESGVEIKVEPAEPEPGMSGSEIVAGAGPVSSMEPPELRSQDLDEEPRSCAAGEICETDGSNGKGDEMPLSSVKTEASPESMLSPSHGSNPIEDPLEAETQHKFELSDSLKEESGTIFGSQIKDAPGEEEEEDGVSEVASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FIP2</accession>
    <name>A0A9J7FIP2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myocyte-specific enhancer factor 2C isoform X5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Mef2c</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027257594.1">
        <property type="nucleotide sequence ID" value="XM_027401793.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027291516.1">
        <property type="nucleotide sequence ID" value="XM_027435715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FIP2"/>
    <dbReference type="GeneID" id="100774573"/>
    <dbReference type="CTD" id="4208"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF145">
        <property type="entry name" value="MYOCYTE ENHANCER FACTOR 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="385"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027257594.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="52310" checksum="4C180F0030F3E7CD" modified="2023-06-28" version="1">MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FIY6</accession>
    <name>A0A9J7FIY6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C1orf141 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CUNH1orf141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">17A/GY</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
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    </dbReference>
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    </dbReference>
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            <begin position="55"/>
            <end position="91"/>
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    </feature>
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        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027258075.1"/>
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    <sequence length="354" mass="40793" checksum="3B920B148A084045" modified="2023-06-28" version="1">MVKHLPTIHEALGSIPSPEQQAVYANPLNSLQSWPRNQCKCLPESSILYPIPAGQSKASKEKVSTPFTGQNERRAKKSMHSTDHSADSIENGRKYHPWVNNLITKEKKSDRDKQARTPCPVNQNVFLPLHIEDVLKNPEIKIIDLGPTDRVLYFMEESHTNPIIFHDTAYIEMLFLAKRFTPYMMTYTTKNVVLEKNLEMLKELFNNQSSYVSNPQSPKPVSKYKDLLIFSSQLVQERINEKRKKKQDSLVSKNRCPSTLYNLSRTLSSITKKFVGYFDKDATQEKSDEIDEFERTFSKTKPSATRKLTTLPIKSDSKPLKNIFEIRKLNNITPLDNLVSWKANDPKNRIHINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FJ10</accession>
    <name>A0A9J7FJ10_CRIGR</name>
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        <recommendedName>
            <fullName evidence="18">Zinc finger protein 827</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Znf827</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, HNRNPK and HNRNPL. Interacts with the nucleosome remodeling and histone deacetylase/NuRD complex. Interacts with RBBP4; the interaction is direct and recruits RBBP4, a component of the NuRD complex, to telomeres.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_007641492.4"/>
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        <property type="nucleotide sequence ID" value="XM_027404893.2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF62">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
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            <end position="397"/>
        </location>
    </feature>
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            <begin position="1208"/>
            <end position="1237"/>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="62"/>
            <end position="76"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
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            <begin position="326"/>
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    </feature>
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    </feature>
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        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00064393"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027260694.1"/>
        </source>
    </evidence>
    <sequence length="1351" mass="148958" checksum="FADCC6FE92763E6E" modified="2023-06-28" version="1">MPRRKQEQPKRLPSHVSRQAEAEGEFSEGEPWYGNSSETPSEASYGEVQENYTLSLEDRIQEQSTSPDTSLGSATPSSHTLELVALDGEILRDSLQCQDHLSPGVSSVCDDDPPSSNKPLSSNLRRLLEAGSLKLDATANGRVESPVNIGSSLSFSPPSHHAQQLSVLARKLAEKQDQNDQYTPSNRFIWNQGKWLPNSTTTCGLSPDSAILKLKAAANAVLQDKSLSRTEESLRFESFSSPFSSQSASSTLAALSKKVSERSLTPGQEHPPPASSFLSLASMTSSAALLKEVAARAAGSLLAEKSSLLPDDPLPLPPSEKKPEKVTPPPPPPPPSAQPQSLELLLLPVSKGRVSKPSNSAPEEESGKPFQCPICGLVIKRKSYWKRHMVIHTGLKSHQCPLCPFRCARKDNLKSHMKVHQHQDRGETFQCQLCPFTSSRHFSLKLHMRCHQHFLRTEAKVKEEIPDPDVKGSPHLSDSGCLGQPREGGGTELVGTVMTSNTPERTGQGGAGVAPLLVKEEPKEDNGLPTSFTLNAADRPANHTKLKDPSEYVSNSAAALFSQDISVKMASDFLMKLSAANHTEPMNLNFKVKEEPKEEESLSAPLPRSSYVFSPEPEVATPNLSEDPLTPQEGKGNVPRRDMSVKAASELLMKLSAESYKETQAVKVKEEPMEVDTQDSPVSISPSRNIGYSTLMGREKIEPLQKLPEGRVPPERNLFSQDISVKMASELLFQLSEKVSKEHNHTKENTIRTTTSPFFSEDTFRQSPFTSNSKDLLPGEAMLHGRIPAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLHTVLVSPPEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSICCTACDFVTMEEAEIKNHIGSKHTGDDRKTPSESNSPSSSSLSTLSDSANGKDDSDSSQKNKGGNNLLVISVLPGSQSSLNSEEKPEKGFECVFCNFVCKTKNMFERHLQIHLITRMFECDVCHKFMKTPEQLLEHKKCHTVPTGGLKCPFCIYSTNRPAAMECHLKTHYKMEYKCRICQTVKANQLELETHTREHRLGNHYKCDQCGYLSKTANKLIEHVRVHTGERPFHCDQCSYSCKRKDNLNLHKKLKHAPRQTFSCGECLFKTTHPFVFSRHVKKHQSGGGPEEDKKGLSPASREPGGPGAPLLVVGGGRSLLSPLSVMSASQALQTVALSAAHGSSSEPNLAFKALAFNGSPLCLDKYRNSDFAHLIPLTMLYPKNHLDLTFHPPRPQTAPPSIPSPKHSFLAYLGLRERAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FJD6</accession>
    <name>A0A9J7FJD6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MCM10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Mcm10</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Self-associates. Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027260990.1">
        <property type="nucleotide sequence ID" value="XM_027405189.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FJD6"/>
    <dbReference type="GeneID" id="100773567"/>
    <dbReference type="KEGG" id="cge:100773567"/>
    <dbReference type="CTD" id="55388"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000006">
        <property type="entry name" value="Minichromosome maintenance 10 replication initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000167">
        <property type="entry name" value="Minichromosome maintenance 10 replication initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor Mcm10 C-terminal" evidence="19">
        <location>
            <begin position="539"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="588"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027260990.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="99000" checksum="E493ED323A53CA68" modified="2023-06-28" version="1">MDVEEDDLSLLTSLLEENEAALHCHSEENNSLSLEDGGPDEFDELFDADGDGESYTEEAEDGEEGKTENQEENLATLFGDVEDLTDDELPTLQVENKVLPVPAPSQEKTNQELQDELKKLQEQMKSLQEQLKAASIKQPSAACLPESPEGASLRPSLKEKKVRRIQESACFSAELDVPALPKAKRVARMPKTHAESSSRTSTLSQPLQVISNFLEAKSSSSMSKSASPPQAVRGNKPTGMTRNQSAGTPGNSEERAPQVPQVSVEAFSGLRLRRPRVSSTEMNRKMTGRKLIRLSQIKEKMATENLEETDWVTFGVILRKVTPQSANSGKTFSIWKLNDLRDLTRCVSLFLFGEVHKDLWKTEQGTVIGLLNANPMKPKEGSEEVCLSIDHPQKVLIMGEAMDLGTCKAKKKNGEPCTQIVNLHDCEYCQYHIQAQYKKLSAKRSDLQSTFSGGRIPKKFRKGTSLKERLCQDGFYYGGVSSESFAASMAAAIAPKKKVQTTLTNLVVKGTNSIIQETKQKLGIPQKSLSCSEEFRELMTLPTFGARNLKHLAKTKASGVIGSPKPAIQSISASALLKQQKQQMLEMRKRKSEEIQKRFLQSSNEAQSPAVPCPSRQSAAQSPRTGAEFPRLERTTAPQMPKLGTGISEGDDVLFFDESPPPRPKLSAAAEAKKLAAIAKLRAKGQILAKTDPNSIVRKQMNPQDVLDVKERAEKSNTVPTEDELEPASKKRREQLAYLESEEFQRILKAKSKHTDILKEAEAELQKSYFEPLVKKEQMEEKMRSIREVKCRVVTCKTCTYTHFKPLETCISEQHNLHWHDGVKRFFKCPCGNRTISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHARFLNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FJS2</accession>
    <name>A0A9J7FJS2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WW domain-containing adapter protein with coiled-coil</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Wac</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A. Interacts (via WW domain) with RNA polymerase II. Interacts with MTOR and other components of the MTOR pathway including RPTOR, RUVBL1, RUVBL2, TTI1 and TTI2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027261284.1">
        <property type="nucleotide sequence ID" value="XM_027405483.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FJS2"/>
    <dbReference type="GeneID" id="100770036"/>
    <dbReference type="KEGG" id="cge:100770036"/>
    <dbReference type="CTD" id="51322"/>
    <dbReference type="OrthoDB" id="10072039at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000020">
        <property type="entry name" value="WW domain-containing adapter protein with coiled-coil isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027261284.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="71234" checksum="34509417A73926F2" modified="2023-06-28" version="1">MVMYARKQQRLSDGCHDRRGDSQPFQGGDVFQALKYSSKSHPSSGDHRHEKMRDAADPSPPNKMLRRSDSPENKYSDSTGHNKAKNVHTQRVREREGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKLAVNSFPKDRDYRREVMQATATSGFTSGMEDKHSSDASSLLPQNILSQTSRHNDKDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTASVPAQKTERKESAPGDKSVSHSCTTPSTSSASGMNPTSAPPTSASTVPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATPQPVTADKQQGHEPVSPRSLQRLSSQRSPSPGPNHTSSSNASNATVVPQNTSARPACSLTPTLAAHFNDNLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FKF4</accession>
    <name>A0A9J7FKF4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-hydroxytryptamine receptor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">5-HT-X</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Serotonin receptor 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Htr7</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262153.1">
        <property type="nucleotide sequence ID" value="XM_027406352.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FKF4"/>
    <dbReference type="GeneID" id="103163243"/>
    <dbReference type="CTD" id="3363"/>
    <dbReference type="OrthoDB" id="10063595at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006939">
        <property type="term" value="P:smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042310">
        <property type="term" value="P:vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000071">
        <property type="entry name" value="5-hydroxytryptamine (serotonin) receptor 7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001069">
        <property type="entry name" value="5HT_7_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00652">
        <property type="entry name" value="5HT7RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 17 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="101"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027262153.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54079" checksum="A92B8199903E89C1" modified="2023-06-28" version="1">MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGVREVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGRCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRSQPESSISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPEKSEFVLKTRALGVHQALENFPWGNGVNTGEKAVNTVALVILIHYYHFNLFTISQVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FUW0</accession>
    <name>A0A9J7FUW0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Retinol-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rbp2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003495531.4">
        <property type="nucleotide sequence ID" value="XM_003495483.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267189.2">
        <property type="nucleotide sequence ID" value="XM_027411388.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FUW0"/>
    <dbReference type="GeneID" id="100758803"/>
    <dbReference type="KEGG" id="cge:100758803"/>
    <dbReference type="CTD" id="5948"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19463">
        <property type="entry name" value="CRBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="4">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027267189.2"/>
        </source>
    </evidence>
    <sequence length="177" mass="20250" checksum="F0800D3DBC941637" modified="2023-06-28" version="1">MTFDSIIFKHQARQTIKQFSSTVSLKPAPSQSSNACTKPEATIMTKDQNGTWEMESNENFDGYMKALGIDFATRKVALCLTQTKIITQDGDNFKTKTNSTFRNYDLDFTVGVEFDEHTKGLDNRHVKTLVTWEGNTLVCVQKGEKENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FWF2</accession>
    <name>A0A9J7FWF2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC103162924 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC103162924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027270107.1">
        <property type="nucleotide sequence ID" value="XM_027414306.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FWF2"/>
    <dbReference type="GeneID" id="103162924"/>
    <dbReference type="KEGG" id="cge:103162924"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027270107.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10480" checksum="184EE8604A05A449" modified="2023-06-28" version="1">MVQLWSTAPHYLLDWIFMLILPFCLCSRKLTCWATSGSSLVFWSSRGQDVSTQAGCVLLVACFQVKNLLHRRILTPTVTWSDVVFKNKPSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FWL7</accession>
    <name>A0A9J7FWL7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2'-5' oligoadenylate synthase</fullName>
            <ecNumber evidence="5">2.7.7.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100768763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 ATP = 5'-triphosphoadenylyl-(2'-&gt;5')-adenylyl-(2'-&gt;5')-adenosine + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34407"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:67143"/>
            <dbReference type="EC" id="2.7.7.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-5A synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.84" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003513120.1">
        <property type="nucleotide sequence ID" value="XM_003513072.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269924.1">
        <property type="nucleotide sequence ID" value="XM_027414123.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FWL7"/>
    <dbReference type="GeneID" id="100768763"/>
    <dbReference type="KEGG" id="cge:100768763"/>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001730">
        <property type="term" value="F:2'-5'-oligoadenylate synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.20:FF:000001">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000007">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.20">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018952">
        <property type="entry name" value="2-5-oligoAdlate_synth_1_dom2/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006117">
        <property type="entry name" value="2-5OAS_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258:SF13">
        <property type="entry name" value="2'-5'-OLIGOADENYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258">
        <property type="entry name" value="2-5 OLIGOADENYLATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10421">
        <property type="entry name" value="OAS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00833">
        <property type="entry name" value="25A_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="11">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="2'-5'-oligoadenylate synthetase 1" evidence="12">
        <location>
            <begin position="165"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027269924.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40576" checksum="D47D7B13A22CC623" modified="2023-06-28" version="1">MGQGLSSAWAWQLDYFIEDHLQPNTDFRKEVKAVIHVMCTFLKERCFQGAAHPVRVSKVVKGGSSGKGKMLTGRTDADLVVFLNNLTSYEDQLNQRGEFLKEIEKKLCQLQGEQNFPVKFEVFRSWGINSPGLILRLSSSELQQEVEFDILLAYDVLGDVSIYNKPDPQIYSSLIRECTSLGLEGEFYTSFTELQGNFLKNRPPKLKNLIRLVKHWYQLCKEKLGEPLPLQYALELLTLYAWERGSRVTEFNTAQGFRTVLELVTKYKQLRIYWTVYYDFQDQEVSNYLHRQLTGARPVILDPADPTRNVAGSNPEGWCRLEGEATAWLQYPCVKNWDSSRVPPWDVPVDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FX55</accession>
    <name>A0A9J7FX55_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box/WD repeat-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Fbxw12</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003504292.2">
        <property type="nucleotide sequence ID" value="XM_003504244.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270433.1">
        <property type="nucleotide sequence ID" value="XM_027414632.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FX55"/>
    <dbReference type="GeneID" id="100763018"/>
    <dbReference type="KEGG" id="cge:100763018"/>
    <dbReference type="CTD" id="285231"/>
    <dbReference type="OrthoDB" id="63265at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22137">
        <property type="entry name" value="F-box_FBXW12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF2">
        <property type="entry name" value="EXPRESSED SEQUENCE C85627-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027270433.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="56291" checksum="908EB954DD9CB504" modified="2023-06-28" version="1">MLPSLAKPLKSEQAVEKSECGLRPCKMEFLLPSVPMVKIFSFLDAFSLLQAAQVNKSWNEVANTDYLWRKLCQKRWFFPDMPRKCWHKQTWKQYFLRQTRQEHTISRAKPEDFIYKEMPGDFGVQGYVSYLSKGGLTMDREGKSVVCVVTSRTKLTAWDIGEGAMTWLSPEQPIDILKLASLPEMHLVITVDKDATVKVWNCRDRDALATNRMLSPCRSLKAVITRHGPVVLAGGTSGDLHTYRVPDLLLISTVHALEAPINQLYCSPHLKWVFLNKKEPRVLPKVFFMDSLLRPAEYPTPVFCVISFTLCVKGFWTPRREDRITLMYQRGAHRTAGFVTFDIELEKTEDKINVEARVVASFKLSCHTQSPEWMGVSDKSVIVCSSGPSLLVYTMTGLQLQRFQDYPEEIMQLLVNPIYVIVTFTDGCLEVYKWEERSYYLTKCYRLQNESHLGQQSMIPKTLCDDVSIIRVVARRAQCFLLAYVMKLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FXL4</accession>
    <name>A0A9J7FXL4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Protein BTG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">Btg3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6 7">17A/GY</strain>
            <tissue evidence="6 7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027268193.1">
        <property type="nucleotide sequence ID" value="XM_027412392.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268194.1">
        <property type="nucleotide sequence ID" value="XM_027412393.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FXL4"/>
    <dbReference type="GeneID" id="100753614"/>
    <dbReference type="KEGG" id="cge:100753614"/>
    <dbReference type="CTD" id="10950"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000002">
        <property type="entry name" value="BTG anti-proliferation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF6">
        <property type="entry name" value="PROTEIN BTG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00960">
        <property type="entry name" value="BTG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Anti-proliferative protein" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027268193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027268194.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29056" checksum="5E902D70453E8DB1" modified="2023-06-28" version="1">MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKNHWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVCCRYGEKNNAFIVASFENEDENKDEISKKVSRALDKVTSDYHSGSSSSDEETSKEVEVKPSSVTATPSPVYQISELIFPPLPMWHPLPRKKPGMYRGNGHQSHYPPPVPFGYPNPGRKNKPYRPIPVTWVPPPGMHCDRNHWINPHMLAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G0T8</accession>
    <name>A0A9J7G0T8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G-protein signaling 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rgs18</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003499271.1">
        <property type="nucleotide sequence ID" value="XM_003499223.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273219.1">
        <property type="nucleotide sequence ID" value="XM_027417418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G0T8"/>
    <dbReference type="GeneID" id="100759408"/>
    <dbReference type="KEGG" id="cge:100759408"/>
    <dbReference type="CTD" id="64407"/>
    <dbReference type="OMA" id="TFFKLMH"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.196.10:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF155">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
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        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="86"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027273219.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27639" checksum="1AE7C4D431864890" modified="2023-06-28" version="1">MEMSLVFFAHLNMCESKEKTFFKLMHGSGKEETGIETKIRAKEKRNRLSLLLQRPDFHGETPTSRSALLAKETRVSPEEAVKWAESFDKLLSHRDGLDAFTRFLKTEFSEENIEFWVACEDFKKCKEPQQISLKAKAIYEKFIRNDAPKEVNLDFHTKEVITKSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSEIYVHLLEGRPQRPTNLRRRSRSFTYNEFQDVKSDVAIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G1R8</accession>
    <name>A0A9J7G1R8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ppp2r5c</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272388.1">
        <property type="nucleotide sequence ID" value="XM_027416587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G1R8"/>
    <dbReference type="GeneID" id="100754775"/>
    <dbReference type="KEGG" id="cge:100754775"/>
    <dbReference type="CTD" id="5527"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027272388.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="67256" checksum="73E39B6B6F5D65E0" modified="2023-06-28" version="1">MPNKNKKEKEPPKPVKSGKGSKEGQEAAEAEIASRKNSLVAVQSSTSAKIKVPVPQPVVPVKKDKRQNSSRFNASNNRELQKLPSLKDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYAVYSQASAMSIPVAMETDGPQFEDVQMLRKTVSDETRQAHKDLKKDRPLVRRKSELPQDPHTEKALEAHCRASELLSQDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G3W9</accession>
    <name>A0A9J7G3W9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100773668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007651147.2">
        <property type="nucleotide sequence ID" value="XM_007652957.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275627.1">
        <property type="nucleotide sequence ID" value="XM_027419826.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G3W9"/>
    <dbReference type="GeneID" id="100773668"/>
    <dbReference type="KEGG" id="cge:100773668"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000358">
        <property type="entry name" value="Serine/threonine-protein phosphatase 4 regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF7">
        <property type="entry name" value="WW-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027275627.1"/>
        </source>
    </evidence>
    <sequence length="999" mass="110310" checksum="5C4F547C26A903EB" modified="2023-06-28" version="1">MAEIPLYFVDLQDDLDDYGFEDCGPDCDNGKVTAFLDIPGHDKLPLLTRLEKRAFSEDVFSRQIVARGLLDVFRDVNGSDKDTLAVMEVAVRLSEDAEPTVRTELMEQIPPIVTFLRESRLDFPVVVSQHLVPVIARYLADVDKQVRKSSQEVLLALLEQDLIAQCDIEGKVCPVLLERSGPDCDDECRAEAMSGPSWTISFPSAAAPLLTCAGDAVCLTLSVNYSSELQTICRMASMVPRNTFTSLLLPRFCELCADNKLFQVRKVCATHFGDICHAVRQEATEKFLIPTFFELCSDNMWGMRKACAECFMAVSYNTSPEVRRAQLSPLFIKLISDPCRWVRQAAFQSLGPFISTFANPSRAGLYIREDGTLSIRPPSQEVESDFASGPPSTHSASSLAGSKTPVHMEPDLLPECASVETSHLHDSSSSSHTTENRSGSPSSARAEMTVISAGNSSCPELPGVSGCPSDSHPEAGPGTPEAMFSTYLYWRAPLPDISEDVEVLLSEARPLEENHSGPEASCDSCVARSEIQKVLQSLQGHLLQDPDIQAQVQVLSAALRATQLGSTSEPESKQTEGLNAESVSDPSPASDNHILLSASSSQNELSVARILQSTDQTEPQNRASGHLGTEQGQEPTTLEENESKASGHLESEQRQEGTALENRAKVQDVIPQPLLDQFVSMTDPARAQTVDMDIAKHCAYSLPGVALTLGRQNWHCLKDTFETLASDGQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRVGVLKHLYDFLKLLHKDKRRAHLRQLQEFVVTDNSRNWRFRYELAEQLILIVDLYGPSDVHGYLRHVALKLCADKVAQVRWISFKLVVVILRKFYSHGASALGLSFIQELISRFRHCPKWVGRQAFACICQAVVSEDSVPVDQFVEHLLPSLLSLASDPVPNVRVLLAKALWQTLLEKAYFRNAGDHHLEVVEETLLALQSDPDQDVSFFASLEPKMQNAADTTVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GC92</accession>
    <name>A0A9J7GC92_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein FAM33A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Ska2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKA2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016831806.1">
        <property type="nucleotide sequence ID" value="XM_016976317.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282144.1">
        <property type="nucleotide sequence ID" value="XM_027426343.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GC92"/>
    <dbReference type="GeneID" id="100755178"/>
    <dbReference type="KEGG" id="cge:100755178"/>
    <dbReference type="CTD" id="348235"/>
    <dbReference type="OrthoDB" id="193920at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000940">
        <property type="term" value="C:outer kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12955">
        <property type="entry name" value="SKA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026762">
        <property type="entry name" value="Ska2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042091">
        <property type="entry name" value="Ska2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32017">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32017:SF3">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16740">
        <property type="entry name" value="SKA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ska2 N-terminal" evidence="14">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027282144.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16033" checksum="E0964096C9073C10" modified="2023-06-28" version="1">MWLERSLRAPRRRRELLHVSPPGAMEDEFQKADSDLDYIQYRLEYEIKTNHPDSAGEKNAVAILKELSAIKSRYQALCARFKPLSIEQKENKSRICATLSKTMTTIQELQKQTDLELTQLTEEEKAVTEQLKSHMPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GH71</accession>
    <name>A0A9J7GH71_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vesicle-associated membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Vamp1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007644735.1">
        <property type="nucleotide sequence ID" value="XM_007646545.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284115.1">
        <property type="nucleotide sequence ID" value="XM_027428314.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GH71"/>
    <dbReference type="GeneID" id="100752483"/>
    <dbReference type="KEGG" id="cge:100752483"/>
    <dbReference type="CTD" id="6843"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000013">
        <property type="entry name" value="Vesicle-associated membrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027284115.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16601" checksum="91DEA63FF8DD2A44" modified="2023-06-28" version="1">MSAPAQPPAEGTEGAAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVRGSPLEKTNTVLDVPRACSKFTLLAHPALAREFFPGFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GI42</accession>
    <name>A0A9J7GI42_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable ribonuclease ZC3H12B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Zc3h12b</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027287656.1">
        <property type="nucleotide sequence ID" value="XM_027431855.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GI42"/>
    <dbReference type="GeneID" id="100774530"/>
    <dbReference type="KEGG" id="cge:100774530"/>
    <dbReference type="CTD" id="340554"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18729">
        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF27">
        <property type="entry name" value="RIBONUCLEASE ZC3H12B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027287656.1"/>
        </source>
    </evidence>
    <sequence length="834" mass="93904" checksum="0DA56CE90BE12B4A" modified="2023-06-28" version="1">MTATAAVETPKMEKSASKEEKQQPKQDSTDRGNADPEEWMSSESDPEHMSFRSGHNSYQPLDTQLKKKEMPSKPHRQLCRSPCLDRPSFSQSSILQDGKLDLEKEYQVKMDFALKLGYAEEQIQSVLNKLGPESLINDVLAELVRLGNKGDSEGQVNLSLLLPRGASSREIASPELSLEDEIDNSDNLRPVVIDGSNVAMSHGNKEEFSCRGIQLAVDWFLDKGHKDITVFVPAWRKEQSRPDAPITDQDILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFDSDGIIVSNDNYRDLQVEKPEWKKFIEERLLMYSFVNDKFMPPDDPLGRHGPSLENFLRKRPVVPEHKKQPCPYGKKCTYGHKCKYYHPERANQPQRSVADELRISAKLSTVKIMSEDTLAKCGTGMSTAKGEITSEVKRVASKRQSDPSIRSVAAEPEEWLPIARKPEASSVPSLVTALSVPTIPPPKSHAVGALNTRSASSPVPGSSHFPHQKASLEHMVSMQYPPILVTNSHGTPINYTEQYPKFETMGDHDYYSVLSDFSKVSINSMHNHEYYMAEANQGVYVRNPSLCTDSHMSHTRNDNYSSYNNLYLAVADAHPEGTLKLHRSASHNHLQPFSHGYHEALARVQSYGSEDSKQAPHKQSVPHLAMHAQNPATGAHSSCSGDYTMPPNVHPMGPSQPGRALVMTRMDSISDSRLYDSNPMRQRRPPLCREQHASWDPLPRAADSYGYHSYPLGNGLMQPCYEPVMVRSMPEKMEQLWRNPWVGMCNDAREHVIPEDQYQTYKNLCNIFPSNVVLAVMEKNPHTADAQQLAALIVAKLRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJF5</accession>
    <name>A0A9J7GJF5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sepiapterin reductase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113837159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027286003.1">
        <property type="nucleotide sequence ID" value="XM_027430202.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJF5"/>
    <dbReference type="GeneID" id="113837159"/>
    <dbReference type="KEGG" id="cge:113837159"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="F:sepiapterin reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051721">
        <property type="entry name" value="Biopterin_syn/organic_redct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44085:SF2">
        <property type="entry name" value="SEPIAPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027286003.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11587" checksum="4DDD90DA761323CE" modified="2023-06-28" version="1">MLLLRACSHLALPHLEEELCTQHPGLGLGRAAADLDTEAVVQQLLCTVCKLPRPKGQQSLLLINNAGTLGDISKGFMNVSDPAEVNNYGALNMTSCSAQLRHPESLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJL6</accession>
    <name>A0A9J7GJL6_CRIGR</name>
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        <submittedName>
            <fullName evidence="16 17">Zinc finger protein 157 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">Znf157</name>
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    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16 17">17A/GY</strain>
            <tissue evidence="16 17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May have a role during differentiation processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003512292.2">
        <property type="nucleotide sequence ID" value="XM_003512244.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007650950.1">
        <property type="nucleotide sequence ID" value="XM_007652760.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027240216.1">
        <property type="nucleotide sequence ID" value="XM_027384415.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288111.1">
        <property type="nucleotide sequence ID" value="XM_027432310.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288112.1">
        <property type="nucleotide sequence ID" value="XM_027432311.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJL6"/>
    <dbReference type="GeneID" id="100770761"/>
    <dbReference type="KEGG" id="cge:100770761"/>
    <dbReference type="CTD" id="7712"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003795">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002737">
        <property type="entry name" value="AGAP008430-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000551">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000128">
        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027288111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027288112.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="58128" checksum="A6A89EFB719BBD5C" modified="2023-06-28" version="1">MYGLRPWVNMPVNEKSPQRCPALIPEEPGRSVEGSVSFEDVAVDFTQQEWYRLDSTQRNMHKDVMLETYSHLASVGLCVAKPDMIFKLERGEELWVLEEESSDHDYSGPLSLLCGNSSVGGDALVLENNVYQYQSIQCGEDFHEETDFVQHKSTHTRDKSFECHECGKVYCRKSNLVEHLRTHTGERPYECGECPKTFSARSYLIAHQKTHTGEKPFGCHECGKSFGRKSQLILHRRTHTGERPYECPECGKTFSEKATLTIHQRTHTGERPYKCNECQKTFRVKISLTQHLRTHTGEKPYECGECGRNFTAKKSLNQHQRIHTGEKPYECGDCGKFFRMKMTLNNHQRTHTGEKPYHCNECGKAFRVQSSLGIHQRIHTGEKPYECNDCGNAFYVKARLIEHQRIHSGEKPYECSDCGKIFSMKKSLRQHKRTHTGEKPYECSECGNAFCVKVRLIEHQRIHTGERPFECQECGKGFCRKAHLTEHQRTHLGRSLLCALEKASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GKV6</accession>
    <name>A0A9J7GKV6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase ERas-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC113837690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027288734.1">
        <property type="nucleotide sequence ID" value="XM_027432933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GKV6"/>
    <dbReference type="GeneID" id="113837690"/>
    <dbReference type="KEGG" id="cge:113837690"/>
    <dbReference type="OrthoDB" id="9835289at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027288734.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18371" checksum="7F7503E494162327" modified="2023-06-28" version="1">MALPTKSSILNLLLNKQCARSPEESYEAWAQCKNAGRKLPEYKVVVFGASGVGKSALTIQMTHHCFVKEHDPTVQDCYWKEVALDNSDYILNVLDTAGLYSDQCLEAGDAVLGVFALDDPSSLDQLQQIWSTWSLQQKQPLPLVLLGNKCDLVTTSEDAHTDAAILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GLA8</accession>
    <name>A0A9J7GLA8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LOW QUALITY PROTEIN: speckle-type POZ protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC113833843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294548.1">
        <property type="nucleotide sequence ID" value="XM_035438657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113833843"/>
    <dbReference type="KEGG" id="cge:113833843"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000003">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="189"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035294548.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40538" checksum="5BCEF084C0DAA570" modified="2023-06-28" version="1">MTEDGAAERWGNTEISVQKFSYSWTISNFRFLLQEVGEAIKSPTFSSGSSVNDKWCLKVRTNGIDEDSQDYLSVHLTLLSCPKSPVRARLQFWIRSVDGEKTNGMITPGFLKFTPNQHWGFTKFIHRDLLLSLESWLLPDNEITVLCDVELEIQDSFINSKASKVPGILVPRCTLADDLGQLWENSVFTDCSLVVAGQEFGAHKAILAARSPVFRAMFENDMEESRKHRVEILDLEPHVFKAMMEFIYTGKAPDLHSMADAVLAAADKYGLEYLKVMCEDALCRDLSVENAAHTLILADXHSAGQLKTKALDFITAHASEVSETSSWKKMVGSHPHLLAEAFSSLASAHSSLLEPPPKRFKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GLT8</accession>
    <name>A0A9J7GLT8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LOW QUALITY PROTEIN: coiled-coil domain-containing protein 120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ccdc120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027289082.1">
        <property type="nucleotide sequence ID" value="XM_027433281.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313474.1">
        <property type="nucleotide sequence ID" value="XM_035457583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760495"/>
    <dbReference type="KEGG" id="cge:100760495"/>
    <dbReference type="CTD" id="90060"/>
    <dbReference type="OrthoDB" id="10063592at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043447">
        <property type="entry name" value="CCDC120/INAVA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16093:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16093">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 120 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytohesin Ubiquitin Protein Inducing" evidence="6">
        <location>
            <begin position="40"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027289082.1"/>
        </source>
    </evidence>
    <sequence length="667" mass="71549" checksum="A854C6305A11BD48" modified="2023-06-28" version="1">MGREPRYXGQVGPDIDTESDRAGQALSSHQPQPPDSTRMEVKGQLISSPTFNAPAALFGEAAPQVKSERLRGLLDRQRALQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQQLPLSAGALVSAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEDPHSCFSLTERPSPPKAWDQFRAASGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGTGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFVARTRRSNSSEALLVDRAAAGGAGSPPAPLPPPAAGPPVCKSSEVLYERPQPVPAFSSRTAGPPDPPRAARPSSAAPASRGPPRLPPVCGDFLLDYSLDRGLSRGAGGAGWGDLLPAPEVPGPLSRRDGLLAMLPGPPPIYTADGSSPLLRSKDPNTRAIRSKPCGLPTEAVEGLEVHPNPLLWMPPPTRLPPAGERGGHKNLALEGLRDWYIRNSGLAMGPQRRPMLPHVGPTHAPFLHARCYEVGQALYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GM34</accession>
    <name>A0A9J7GM34_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="11">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Gapdhs</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="11"/>
    <dbReference type="RefSeq" id="XP_016832671.1">
        <property type="nucleotide sequence ID" value="XM_016977182.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286886.1">
        <property type="nucleotide sequence ID" value="XM_027431085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GM34"/>
    <dbReference type="GeneID" id="100767862"/>
    <dbReference type="KEGG" id="cge:100767862"/>
    <dbReference type="CTD" id="26330"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF79">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="85"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027286886.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="45365" checksum="22AAE4CDC29C5CE3" modified="2023-06-28" version="1">MSKRDVVLTNVTVVQLLRQPCPVTREPPPPPPECKLEEPPPRAPSPPPPPPPPPPTQVKEERPLPPPSPPPPPPPQPPKKPMKELTVGINGFGRIGRLVLRVCMEKGIKVVAVNDPFIDPEYMVYMFKYDSTHGRYKGTVEHKNGRLVVDNLEINVYQCKDPKDIPWRSVGSPYVVESTGVYLSIEAASAHISAGAQRVVVSAPSPDAPMLVMGVNEKEYNPGSMNIVSNASCTTNCLAPLAKVIHERFGIVEGLMTTVHSYTATQKTVDGPSKKDWRGGRGAHQNIIPSSTGAASAVGKVIPELKGKLTGMAFRVPTPDVSVVDLTCRLAQPASYSDIKEAMKSAAKGPMAGILAYTEDQVVSTDFIGDPHSSIFDAKAGIALNDNFVKLVSWYDNEYGYSNRVVDLLRYMFSREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GNE8</accession>
    <name>A0A9J7GNE8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118238167</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118238168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118238167</name>
        <name evidence="4" type="synonym">LOC118238168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4">17A/GY</strain>
            <tissue evidence="3 4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035294575.1">
        <property type="nucleotide sequence ID" value="XM_035438684.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035294576.1">
        <property type="nucleotide sequence ID" value="XM_035438685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GNE8"/>
    <dbReference type="GeneID" id="118238167"/>
    <dbReference type="KEGG" id="cge:118238167"/>
    <dbReference type="KEGG" id="cge:118238168"/>
    <dbReference type="OrthoDB" id="9633598at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035294575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035294576.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31943" checksum="B06D8501304A91A1" modified="2023-06-28" version="1">MAETEVGKSVSEFPDTLSPSPIDTKQPVKQIGEESGGNADRSSEVSPGGEGSGELAREHALKLQLVEALAKEALGTVRGPERSSENKRQSREDKEPRQKRPRQSSGGSFCRPHHRRARGHLEDKSRASPPPARDRGRHKPQSTPAKQHWARDSQARHSEPRVKDRRPHPRSLVRPIKRERSQDTRAAPSNTRKRTRQDSAEAGCSRELSLLSRVRAHMGALEVALEELQGPGGAFLPEPSVSTEPRVSQRAWLSWQLSHAGAALHWALHTVNTILANQPRMPRYPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GPZ3</accession>
    <name>A0A9J7GPZ3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Syncoilin isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Sync</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035295493.1">
        <property type="nucleotide sequence ID" value="XM_035439602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GPZ3"/>
    <dbReference type="GeneID" id="100757588"/>
    <dbReference type="CTD" id="81493"/>
    <dbReference type="OrthoDB" id="8842296at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045103">
        <property type="term" value="P:intermediate filament-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027702">
        <property type="entry name" value="Syncoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47147">
        <property type="entry name" value="SYNCOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47147:SF1">
        <property type="entry name" value="SYNCOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="159"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="345"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035295493.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53599" checksum="47F3FCCD6BCC715F" modified="2023-06-28" version="1">MASPEPLRGGDGARAARETGTEASCSLQDSESRKETMTFSPEATLSLEGTVNLDDILFLGDSGDFEESLYVEEFEKPEETLYIEESKQPEEALDLGEPVSPEDTPPVEEPVKPDEGQFSKHVEPAKSPSPEQTAGEGEMVALEEGLPAPPSPSTEEDLSVEDLALLEGRFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRMVKQKLFKVTKECVAYQYQLECRQQDVAQFADCREALSTRAAQLSGELTQLRDAYQKQKEQLQQQLEAPPTQSDGHFLQESRRLSTQFENLMAESRQGLEAEYEPQLLRLLERKEAGTKALQDTQAEIQKMKEALRPLQAEARQLHLQNRNLEDQITLVRHKRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRISLAEELSTYKATIPKSLEQADTATSQAGGAEAQSQGDLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GR49</accession>
    <name>A0A9J7GR49_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100771998</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70671"/>
            <dbReference type="Rhea" id="RHEA-COMP:17947"/>
            <dbReference type="Rhea" id="RHEA-COMP:17948"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:189855"/>
            <dbReference type="ChEBI" id="CHEBI:189856"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70672"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="11"/>
    <dbReference type="RefSeq" id="XP_035297540.1">
        <property type="nucleotide sequence ID" value="XM_035441649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771998"/>
    <dbReference type="KEGG" id="cge:100771998"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF7">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="123"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="291"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035297540.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="52188" checksum="64C9A5E9E4F06FFB" modified="2023-06-28" version="1">MMEGNGNGYEHCNDCENEEDNSYNRGGLSPVNDTGVKKKKKKQKKKKEKGNDTDSAQDQSLKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTKPVPKLGEVVNTHGPVEPDKDNIRQEPYTLLQDFTWDALDMGDRGVLKELYTLLNENYVEDDDNMFRLDYSPKFLLWALRPPGWLPQXHCGVRVVSSRKLVGFISAIPAIIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIQEITRRVQLEGIFQAVYTAGLVLPKPVDTCRYWHWSLNPRKLIKVKLSHLSRNTTMQCTMKLYQLPETPKTAGLRPMEKKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSLYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSNALVLAKMKGFDVFNALDLMENKTFLEKLKFGVGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GSK9</accession>
    <name>A0A9J7GSK9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sperm-associated antigen 16 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pf20 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC100761061</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with SPAG6 and STK36.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035296911.1">
        <property type="nucleotide sequence ID" value="XM_035441020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GSK9"/>
    <dbReference type="GeneID" id="100761061"/>
    <dbReference type="KEGG" id="cge:100761061"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000787">
        <property type="entry name" value="sperm-associated antigen 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001241">
        <property type="entry name" value="Sperm-associated antigen 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="488"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="293"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035296911.1"/>
        </source>
    </evidence>
    <sequence length="645" mass="71900" checksum="DC8E027AF61A3FAF" modified="2023-06-28" version="1">MAASRGVPPMRVLEEALGISFSPTDDTAETGAASAGDGAYYLEQVTITEASEDDCEYEEIPDDNFSIPEGEEDLAKAIHMVQEQATDVQILEQKTVLPSRHVAHEAIEDFLCNFLIKMEMCRTLDCFQAEWYELIQKGGSDLRALSNVPDVYNQVMLLENENKNLKKDLKHFRQAAEKAKEDLLKTRKERDFHRMHHKRILQEKNKLIADLKGLKLHYASFEPTIRVLHEKHHALVKEKMLTSLERDRAVGKISGLQATLKNIDIGHIQVPVIKGKHESSAITHNLGDRATIGHSCEKENKPEGPTQKCLREGREENGTKPKTKSERKDSEFPTDMQPDPNLTACKENLSPTKFDYKLNNIFRLHELPVSCIAMHPSKDILVSCSEDRLWKMVGLPKGNVLLTGSGHTDWLSDCCFHPSGNKLATSGGDATVKIWDLAKGDCILTFEGHNHAVWSCTWHSGGDFVASASLDLTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFANTLLTASADKTLSVWDARTGKCEHSLYGHMHSINDATFTSRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSPGNEVNFDSTGRVLAQASANGVIHLLDLKSGQIHKLVGHESEVHTVVFSHDGNNLYSGGSDGTIRLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GTP3</accession>
    <name>A0A9J7GTP3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger C2HC domain-containing protein 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Zc2hc1a</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295886.1">
        <property type="nucleotide sequence ID" value="XM_035439995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GTP3"/>
    <dbReference type="GeneID" id="100756742"/>
    <dbReference type="CTD" id="51101"/>
    <dbReference type="OrthoDB" id="10066537at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF25">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="9">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035295886.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="39858" checksum="90ECCA19A66652B9" modified="2023-06-28" version="1">MEGQEENGSVVQVGELLPCKICGRTFFPLALKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYDPDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTESKGKQASRPQYKPSPLKKSSSPGTTSSGSSRLPQPSTTSKTVVGVPSGKASSINSSLGNKLQTLSPSHKAIAAPQAGKMGKLGPPLRTGRHVKRLYDSDTKSDSAFKRHELLPIYKANIKSRNTTPPSLARNSVSGVFTNKRKTFTDSYAARPDGDYTSSINGGNIKGIEGHSSVHLPKFCHECGTKYPVEWAKFCCECGIRRMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUX3</accession>
    <name>A0A9J7GUX3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">snRNA-activating protein complex subunit 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107978450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035298238.1">
        <property type="nucleotide sequence ID" value="XM_035442347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GUX3"/>
    <dbReference type="GeneID" id="107978450"/>
    <dbReference type="KEGG" id="cge:107978450"/>
    <dbReference type="OrthoDB" id="6158499at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029138">
        <property type="entry name" value="SNAPC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15333">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15333:SF2">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15497">
        <property type="entry name" value="SNAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035298238.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11071" checksum="38BDAB58ABA110CD" modified="2023-06-28" version="1">MLSWLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGTETLSSHPAPEQLHDMSVHVDNEASINQTTLKLSTRSPMEEEEEEEEESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GWL2</accession>
    <name>A0A9J7GWL2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Neuronal acetylcholine receptor subunit alpha-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Chrna3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258747.2">
        <property type="nucleotide sequence ID" value="XM_027402946.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300289.1">
        <property type="nucleotide sequence ID" value="XM_035444398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GWL2"/>
    <dbReference type="GeneID" id="100763280"/>
    <dbReference type="KEGG" id="cge:100763280"/>
    <dbReference type="CTD" id="1136"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
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    <keyword evidence="10 22" id="KW-0675">Receptor</keyword>
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            <begin position="2"/>
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    <sequence length="439" mass="50430" checksum="DF9154E6005F0FBC" modified="2023-06-28" version="1">MSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMHVPAEKIWKPDIVLYNNADGDFQVDDKTKALLRYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGLWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAIFLNLLPRVMFMTRPTSSEGEAQKPRTFYSAELSNLNCFNRADSKSCKEGYPCQDGTCSYCHHRRVKISNFSANLTRSSSSESVDAVLSSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GWX5</accession>
    <name>A0A9J7GWX5_CRIGR</name>
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        <recommendedName>
            <fullName evidence="9">Inverted formin-2</fullName>
        </recommendedName>
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        <name evidence="15" type="primary">LOC100751534</name>
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    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Severs actin filaments and accelerates their polymerization and depolymerization.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the formin homology family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="INVERTED FORMIN-2"/>
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    </dbReference>
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        <property type="entry name" value="Drf_GBD"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="12">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="13">
        <location>
            <begin position="553"/>
            <end position="943"/>
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    </feature>
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        <location>
            <begin position="971"/>
            <end position="986"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="386"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="400"/>
            <end position="526"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="924"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1133"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035301189.1"/>
        </source>
    </evidence>
    <sequence length="1229" mass="134131" checksum="A570556E2A9A0FDC" modified="2023-06-28" version="1">MSVKEGAQRKWAALKEKLGPQESDPTEANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGRGVARIADALLQLTCISCVRAVMNSKQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLSVINAIILGPEDLRTRAQLRSEFIGLQLLVTLTRLRDLEDADLLIQLEAFEEAKAEDEEELQRVCDGVNMNSHQEVFASLFHKVSCSPASAQLLSVLQGLLHLEPAGRPGQLLWEALENLVNRAVLLASDAQACTLEEVVERLLSIKGRPRPSPLDKAHKSVQANLGQNRGSSSKNTTTPSAKWEGQQPVAASTCQCVGSFHSASDDTAQQPTALEKADSPPPTPPLSSSTPVLPPXPPPLPGQGAMSXPPPPPPPPLPPPLPGSGTISPSLPPPPPPLPGSKAMSPPAPPPPPPLSDSWRTLPPPPPPLPGTGGIPPPPPPLPGFSVPSTMGVVEEVIVAQVDHGLGSAWVPSHRRVTPPTLRMKKLNWQKLPSNVARERNSMWATLSSPCTEAVEPDFSSIEQLFSFPTAKPKEPSAAPTRKEPKEVTFLDSKKSLNLNIFLKQFKSSNEEVTSMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERTKLASADQFYILLLDIPCYQLRVECMMLCEGTAIVLDMVRPKAQLALTACESLLTSQRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLARDLEPPSQAAGINLEIIRSEASGNLKKLLEIERKVSASIPEVQKQYAERLQASIEASRALDKVFEAIEQKKLELADYLCEDPQQLSLEDTFSTMKTFRDLFTRALKENKDRKEQMAKAEKRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTEAGSRVTPTDPPKATEPATASNAIQSTNHPASEPSLDTTAAGEPQGWDLVDAVTPSPQPSKEEGGPPALERRSSWYVDASDFLVPEDNLNAQPSEGVWPVTLGDDQALKPLEFSSNKPPGVESSPQNAVDPEALWGVRQAKADGTREGPEDTAERGHSPHLPCTGPGEDEDQDDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVRGRVSKGTSKRRKKRPSRNQEGLRSRPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GYI4</accession>
    <name>A0A9J7GYI4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Resistin-like gamma isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100756330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistin/FIZZ family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300235.1">
        <property type="nucleotide sequence ID" value="XM_035444344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GYI4"/>
    <dbReference type="GeneID" id="100756330"/>
    <dbReference type="KEGG" id="cge:100756330"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16333">
        <property type="entry name" value="RELM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4230:FF:000001">
        <property type="entry name" value="Resistin-like beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4230">
        <property type="entry name" value="Resistin head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009714">
        <property type="entry name" value="RELM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036262">
        <property type="entry name" value="Resistin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21101">
        <property type="entry name" value="RESISTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21101:SF5">
        <property type="entry name" value="RESISTIN-LIKE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06954">
        <property type="entry name" value="Resistin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111423">
        <property type="entry name" value="Resistin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039896935" evidence="7">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035300235.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11901" checksum="4B12361B2D608BF0" modified="2023-06-28" version="1">MKTTICSLLIIISLLQLMVPVNTEETLDSVMKSLKELLSYHDGRRSTMTKTLSCTSVKAMGTLSSCPSGMTVTGCSCGFACGSWNVQNENVCHCLCPVIDWTVARCCKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H274</accession>
    <name>A0A9J7H274_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Hydroxyacylglutathione hydrolase-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">Haghl</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8 9 10">17A/GY</strain>
            <tissue evidence="8 9 10">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303295.1">
        <property type="nucleotide sequence ID" value="XM_035447404.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303296.1">
        <property type="nucleotide sequence ID" value="XM_035447405.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303297.1">
        <property type="nucleotide sequence ID" value="XM_035447406.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311130.1">
        <property type="nucleotide sequence ID" value="XM_035455239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H274"/>
    <dbReference type="GeneID" id="100772931"/>
    <dbReference type="CTD" id="84264"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF77">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035303295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035303296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035303297.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34693" checksum="36048091121923BC" modified="2023-06-28" version="1">MKVKVIPVLEDNYMYLIIEEHTREAVAVDVAVPKRLLEITAREEVSLTTVLTTHHHWDHTRGNAELAHLRPGLEVMGADERICALTRRLSHGEELRFGAIHVRCLLTPGHTTGHMSYFLWEDECPDPPALFSGTLQPGFIHLCNSTVPSLPPSDPFSSLGDALSVAGCGWHLEDTAQQMYQSLAKILGTLPPQTKVFCGHEHTLSNLEFAQKVEPCNNHVQAKLSWAQKRDDDDIPTVPSTLGEELLYNPFLRVTEDPVREFTGQVAPAQVLEVLCRERARFQLALEPLQPQVRALLALQWGLLSTPQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H379</accession>
    <name>A0A9J7H379_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RUN domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Rundc1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304111.1">
        <property type="nucleotide sequence ID" value="XM_035448220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H379"/>
    <dbReference type="GeneID" id="100752621"/>
    <dbReference type="CTD" id="146923"/>
    <dbReference type="OrthoDB" id="10068328at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000012">
        <property type="entry name" value="RUN domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194:SF5">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194">
        <property type="entry name" value="SORTING NEXIN-29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="427"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00055063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035304111.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="67903" checksum="60AC5FEC30D4FC35" modified="2023-06-28" version="1">MAAVEAATELGTVVTAFEPKAKDEEEEDEEEESLPPCEAVRWAPVGAVAEAGPGAAAFSEEAAAAAEEPGAAAGSPPDATVLTLRRLQAERRQLDSALLALSSHFAQVQFRLRQVVRGAPAEQQRLLRELEDFAFRGCPHVLGYEGLQGPCGGDGGGGGLPDDRPRVRGEDQSEQEKRERLETQREKQKELILQLKTQLDDLETFAYQEGSYDSLPQSVVLERQQVIIDELIKKLDMNLNEDISSLSTEELRQRVDAAVAQIVNPARVKEQLVEQLKTQIRDLEMFISFIQDEVGSPMQTSGHCECKASGKSGNGFTRTGSSSVPPGAGKTAKAEDVKRVRETGLHLMRRALAVLQIFAVSQLGCATGQIPQSLWQRDQADRDYSPLLKRLEVSVDRVKQLALRHQPHDHVITSANLQDLSLGGKDELTMAVRKELTVAVRDLLAHGLYATSSGMSLVMAPIACLLPAFSSAPETMHPWELFVKYYHAKNGRAYVDSPARKLSQSFALPVMGGSAVTPKQSLLTAIHLVLTEHDPFKRSADSELKALVCMALNEQRLVSWVNLICKSGSLIESHYQPWSYMAHTGFESALNLLSRLSSLKFSLPVDLAVRQLKNIKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4S3</accession>
    <name>A0A9J7H4S3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LOW QUALITY PROTEIN: tRNA (Adenine(58)-N(1))-methyltransferase, mitochondrial isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Trmt61b</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035303502.1">
        <property type="nucleotide sequence ID" value="XM_035447611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761233"/>
    <dbReference type="KEGG" id="cge:100761233"/>
    <dbReference type="CTD" id="55006"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000003">
        <property type="entry name" value="tRNA (Adenine(58)-N(1))-methyltransferase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054151">
        <property type="entry name" value="TR61B_FKBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21985">
        <property type="entry name" value="TR61B_FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TR61B FKBP-like" evidence="5">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035303502.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="26344" checksum="89BCF86DEA551FFA" modified="2023-06-28" version="1">MRGTACAGRPRLPLWVSGASGLGVSSLRKTSGCGGAGVESRAAATPSSLPPSLRRAVAAGSACCPVRGGSVATEPGKPHVPSSCSPSREGPFPAGELILAQTGKXQTQFKKXFHQCSVGRFNNNWXAIPFSEIVGKLPGLMVTGSSATDDGHEPRDTVLETDSGCGEMSLFLSKAGTYTNIITQVMELLDGIGTCELALMXTDKXDWLMCLTKQISGILPPKVXTKINADLQLHFQKEIGVGNEVFQENCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H8Y4</accession>
    <name>A0A9J7H8Y4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Fibronectin type III domain containing protein 3C1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14 15" type="primary">LOC100765442</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11 12 13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11 12 13">17A/GY</strain>
            <tissue evidence="11 12 13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNDC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306180.1">
        <property type="nucleotide sequence ID" value="XM_035450289.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306181.1">
        <property type="nucleotide sequence ID" value="XM_035450290.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306182.1">
        <property type="nucleotide sequence ID" value="XM_035450291.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306183.1">
        <property type="nucleotide sequence ID" value="XM_035450292.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306184.1">
        <property type="nucleotide sequence ID" value="XM_035450293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765442"/>
    <dbReference type="KEGG" id="cge:100765442"/>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000180">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000373">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF14">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN CONTAINING 3C2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1461"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="582"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="682"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="779"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="874"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1332"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035306180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035306181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035306182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035306183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035306184.1"/>
        </source>
    </evidence>
    <sequence length="1486" mass="164208" checksum="C3C15C56AFAAB006" modified="2023-06-28" version="1">MEHQFPPILAEIYPTVPFINGDPTYPMENWTLDPNAMATYSHYSQTMIQPKIYNTWTSCPQYWTQVIFIQVNPGEVLTIKADDGSVQHIQGPADVPLIAPTGNLPPIYLPPGYISQVVEENGIQKIIVVPQTLDYNMALSAPGHQLSPFIAPPQFTYPQALPFMYPPVQGEFPMPYMQEFVPQQIPLPAPPLPPPMLPPPMLPPPMLPPPMLPPPMLPPPMLSPPMLPPPMLPPPMLPPPMLPPPMLPPPMLPPPMLPPPMLPPLVVLQPLMLPPPMLPPPMLPPPMLPPPMLPPPMLPPPMLPPPMLPPPMLPRPVLPPPMLPPPPAFMYQEHHETYLQGRVNHNQFVERTVKTGDYSKKKMRDRQFGEHKTRSMFNDTPLLLNKTIDMSATHTPGIHIDNNTSSICSLNNILSTCAIDNTPKNYIANSLLDINTTNKITSSSDHAPSTSTSNTALCFDTINSAPSLSRISHDPVTSAGTQKYSNADSTPRCISESAHYVLISENAHIPSSITNALRPSGAASISNITRAYTENNHGKRENNMGGGDNKQMSGGKQKKTQSSNAALKENNTEYRTQPCCFNIEKPVVSDIQTRSATVSWNPNSTENSDHINSPVTFELALSSNGKNGIYKNIYNGKEVTVALHDLQPCTVYFLRITTVRGEEHRSVSEVISFTTPGCEPDPPLAPKLINRTKNSLNLQWKGSKDNGSKISSFLLEWDEGKGEEFKSCYSGSMKQHKIFKLMASTKYSFRLAAKNNFGFSNFSEIAVFYTSGNTPPAPLPPKLKEAGVYSLSLEWCAPTNPNPNDTLTYVLEMEEPRSGLGFKPKYNGEDLSCTVRNLQRNTAYKFRIFAYNLEGRSNSSGEVKYSTRPAKPGYPKKPYVVGAIYAHQVKIGWDSPKDNGGMHISSYSLEVSENSDGANVWKIIYNGTLQEFLYNDLQPGTTYKLRVFCTSPVGQSQPSDVLTIQTPTLPQESCRSLPLNGKTKCKNTNLLLGNRSVTGNLETVVRGKKAKSPRNDRKGSPGSEKKCALGSHSMKCGTVPARHPPSQCGTPVLTCKGPTCVIVSWEIPKCNGAEITDYRLQWGQIEDSMHLIYTGPCLRYEVKGLIPATTYFCRVQAVNIVGVGMFGGTGKVTTPGTVPAIVPMLQEVEDKVPAKLSSSCIAIQWEEPDCHGSPITGYNIEYGDKKILTVDRVTECVLKNLQPNTTYRIRIQAINHYGLSPFSPPIRSKTKPLPPEPPLLDCVVCGHQSLRFKWGNASNKKSLANFISYNLLMEDRSGRFSVIYHGPDLTHKVQKLSEYTQYKFKIQACNEAGEGPQSDVYTFTTTKTPPAALKAPKLHPLNNNSCEIKWDSLNPVKGDPIIYCLQVITGKKAEQIYKGPNTTFCFSNYLANSRYRFKVCAGRQYENSDGVQELWGPYSPSTLFSTYKHQSGHGKGGGGKGKGNHNDKDEKYKTEMRDDTFVLILMIGFALIAILCAVAIQYFLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H9R7</accession>
    <name>A0A9J7H9R7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase TRIM39</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING-type E3 ubiquitin transferase TRIM39</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Tripartite motif-containing protein 39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29 30 31" type="primary">LOC100773524</name>
    </gene>
    <organism evidence="28 31">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29 30 31" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29 30 31">17A/GY</strain>
            <tissue evidence="29 30 31">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="RefSeq" id="XP_027244396.1">
        <property type="nucleotide sequence ID" value="XM_027388595.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244397.1">
        <property type="nucleotide sequence ID" value="XM_027388596.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306464.1">
        <property type="nucleotide sequence ID" value="XM_035450573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H9R7"/>
    <dbReference type="GeneID" id="100773524"/>
    <dbReference type="KEGG" id="cge:100773524"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19780">
        <property type="entry name" value="Bbox2_TRIM39-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13745">
        <property type="entry name" value="SPRY_PRY_TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000171">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035033">
        <property type="entry name" value="PRY/SPRY_TRIM39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="26">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="27">
        <location>
            <begin position="289"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027244396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027244397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_035306464.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="56214" checksum="BD678F7A491A1B1A" modified="2023-06-28" version="1">MAQTSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQTVKRKIRDESLCSEHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLEEISCCKASEEKKPGELKRLVESRRQQILKEFEELHRRLDEEQQTLLSRLEEEEQDILQRLRENAAHLGAKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCDKVKTMEVTTVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPQRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCJ9</accession>
    <name>A0A9J7HCJ9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Speckle-type POZ protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100774529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307657.1">
        <property type="nucleotide sequence ID" value="XM_035451766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCJ9"/>
    <dbReference type="GeneID" id="100774529"/>
    <dbReference type="KEGG" id="cge:100774529"/>
    <dbReference type="OrthoDB" id="9620072at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000003">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="190"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035307657.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41424" checksum="4CF84BA58FF4A5B7" modified="2023-06-28" version="1">MSEDRAVERSGHTNFSVQKFSYSWTISNFRFLLQEIGDAIKSPTFSSGLLSDNDKWCLKILPNGIDEESKDYLSVHLTMLSCPTIPAWARFRFWIISVDGEKTNGKISPRFFKFMPKQHWGFKKFIHRDLLSFVESWLYPDNELTIFCEVDLVVQDSLINSGKSTVPGIQVPRYTLEDELGQLWENSLFTDCCLVVAGQEFQAHKAILAARSPVFRAMFQHDMEEKRKNRVEIQDVEPQVFKTMMDFIYTGKAPDLHSMADAVLAAADKYGLERLKVMCEDALCRDLCVENAAHTLILADLHSAGQLKTKTLDFITAHASDVSETSSWKTMMVLHPQLLAEAYSSLASTHRSLLEPPPKRLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J8P2</accession>
    <name>A0A9J7J8P2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 178B isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Tmem178b</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM178 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027247333.1">
        <property type="nucleotide sequence ID" value="XM_027391532.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J8P2"/>
    <dbReference type="GeneID" id="100774962"/>
    <dbReference type="KEGG" id="cge:100774962"/>
    <dbReference type="CTD" id="100507421"/>
    <dbReference type="OrthoDB" id="8809386at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039625">
        <property type="entry name" value="T178A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039885794" evidence="8">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027247333.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33349" checksum="D13DE2D101F949C4" modified="2023-06-28" version="1">MAAGRLLLYTGLSLALCALGMLAVAICSDHWYETDARKHRDRCKAFNTRRVDPGFIYNNNNNLPLRASRSRLDRWEGKLLRARNRRQLFAMSPADECSRQYNSTNMGLWRKCHRQGFDPEIAALIRKGEIERCTYIKYHYSSATIPRNLTFNITKTIRQDEWHALHLRRMTAGFMGMAVAIILFGWIIGVLGCCWDRGLMQYVAGLLFLMGGTFCIISLCTCVAGINFELSRYPRYLYGLPDDISHGYGWSMFCAWGGLGLTLISGFFCTLAPSVQPVPRTNCPKSRPENGTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JD52</accession>
    <name>A0A9J7JD52_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Elongin 18 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SIII p18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC100758808</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (either CUL2 or CUL5), a catalytic subunit (either RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1 or RAB40C. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Elongin B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027253928.1">
        <property type="nucleotide sequence ID" value="XM_027398127.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JD52"/>
    <dbReference type="GeneID" id="100758808"/>
    <dbReference type="KEGG" id="cge:100758808"/>
    <dbReference type="OrthoDB" id="7537057at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000108">
        <property type="entry name" value="Elongin-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="18">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027253928.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12908" checksum="1958166C1E1492C5" modified="2023-06-28" version="1">MAVFLMIRRHKTTIFTDAKESSTVSELKPIVQGFLKQEPYKQHLYKDDNLLFDSKTLGKSGFTSQTAGPQAPATVGLAFLAGDAFEDLRIEPFSSPPDPSHVMKPQDSGGSAHEQAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JD81</accession>
    <name>A0A9J7JD81_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Wnt10b</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027251821.1">
        <property type="nucleotide sequence ID" value="XM_027396020.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JD81"/>
    <dbReference type="GeneID" id="100766340"/>
    <dbReference type="KEGG" id="cge:100766340"/>
    <dbReference type="CTD" id="7480"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:frizzled binding"/>
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        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:canonical Wnt signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
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        <property type="entry name" value="Wnt10"/>
    </dbReference>
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        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF76">
        <property type="entry name" value="PROTEIN WNT-10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WNT10PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
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        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039951911" description="Protein Wnt" evidence="13">
        <location>
            <begin position="29"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027251821.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43049" checksum="7516512B269B619A" modified="2023-06-28" version="1">MLEEPGSRPPPLGLAGLLFLALFTRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRSPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSQPSPIPGSDSSPSPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAIGAALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTVGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JGU7</accession>
    <name>A0A9J7JGU7_CRIGR</name>
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        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Smim15</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007646152.1">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027401513.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="100755813"/>
    <dbReference type="KEGG" id="cge:100755813"/>
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    <dbReference type="OrthoDB" id="6282848at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027877">
        <property type="entry name" value="Smim15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28644">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28644:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027257314.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15008" checksum="E1A294B20538F6DF" modified="2023-06-28" version="1">MDEDVVKWNSNLSKVYGQTKEDKNQHHLNCDWLIFPGKIRDHYSSISPSFLLATKMLDIKAWAEYVVEWAAKDPYGFLTTVILALTPLFLASAVLSWKLAKMIEAREKEQKKKQKRQENIAKAKRLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JL96</accession>
    <name>A0A9J7JL96_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">LOW QUALITY PROTEIN: zona pellucida sperm-binding protein 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Zp2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Zona pellucida</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027266150.2">
        <property type="nucleotide sequence ID" value="XM_027410349.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100771444"/>
    <dbReference type="KEGG" id="cge:100771444"/>
    <dbReference type="CTD" id="7783"/>
    <dbReference type="OrthoDB" id="9903747at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035805">
        <property type="term" value="C:egg coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032190">
        <property type="term" value="F:acrosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035804">
        <property type="term" value="F:structural constituent of egg coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060468">
        <property type="term" value="P:prevention of polyspermy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3210:FF:000006">
        <property type="entry name" value="Zona pellucida sperm-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057637">
        <property type="entry name" value="Ig_ZP2_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057638">
        <property type="entry name" value="Ig_ZP2_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057636">
        <property type="entry name" value="Ig_ZP2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051148">
        <property type="entry name" value="Zona_Pellucida_Domain_gp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23343">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23343:SF4">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23736">
        <property type="entry name" value="Ig_ZP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23740">
        <property type="entry name" value="Ig_ZP2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23738">
        <property type="entry name" value="Ig_ZP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0278">Fertilization</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="14">
        <location>
            <begin position="365"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027266150.2"/>
        </source>
    </evidence>
    <sequence length="710" mass="79784" checksum="BF8E21D0C7AE8C62" modified="2023-06-28" version="1">MVWRWRRESVSLPCFRSTYRSIFLLFALGSSVNSLSLPQWKDPDFPVTVTCDENEVRLKFPSSFDMEKWQPSVVDTSGDKILNCTYALDSEKLIMKFPYEPCATSVFGGYQVTIRVQDNSTDIKSGMHHFSCPFMKTEIHEVSEVVVCTKDFVSFSFPYVFSKLADDDQKNASETGWIVKLGNGTRVHTLPLKDALIQGFSLLIDTRKITLDVPINATGVAHYVQGSSRLSTVELQLLFSIPGQKVTFFSQAVCASDLSVACNATHMTLTIPEFPGKLKSVDFGKSSIPEMQWHANGIDKEATNGLRLHFRKTLLKTKPSEKCPPYQFYFSSLKLNFYLQSDMVSLVIDPECHCESPVSIVADELCTQDGFMDFEVYSHQTKPALNLETLLVGNSSCQPNFKSQSQGLVRFHIPLNGCGTGQKFEGDKVIYENEIHALWKNLPPSIIFRDSEFRMTVRCYYTKGSVPLNANIKSLLSPVASVKPGPLMLVLQTYPDKSYQQPYRKDEYPLVRYLRQPIYMEVTVLNRNDPSIKLVLDDCWATSSRDPASVPSGTLSWMAVNMNWTXYRTTFHPAGSSVVHPTHYQRFDVKTFAFVSEAQGLSSLIYFHCSALICNRGSLDSPLCSVTCPAPLRSKREAIKEDTMTVSLPGPILLLSDDSSLKDDMVPNRHEIAKDTASKTVTIVAALVGSVVIVGFIYYLHKERTMRLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JMB2</accession>
    <name>A0A9J7JMB2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Pou2f3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007651659.1">
        <property type="nucleotide sequence ID" value="XM_007653469.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267695.1">
        <property type="nucleotide sequence ID" value="XM_027411894.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JMB2"/>
    <dbReference type="GeneID" id="100764501"/>
    <dbReference type="KEGG" id="cge:100764501"/>
    <dbReference type="CTD" id="25833"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000972">
        <property type="entry name" value="TF_octamer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF81">
        <property type="entry name" value="POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00029">
        <property type="entry name" value="OCTAMER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="13">
        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="279"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="281"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027267695.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="47414" checksum="BD54E0D5EA64E45A" modified="2023-06-28" version="1">MVNLEPMHSEIKMSGDVADSTDARSTFSQVESGNDRNGLDFNRQIKTEDLGDSLQQSLSHRPCHLSQGPTMMPGNQMSGVGAGPCQDMASLHPLQQLVLVPGHLQSVSQFLLSQTPPGQQGLQPNLLSFPQQQSTLLLPQTGPGLTSQAVGRPGLSGSTLEPHLEAPQHLPVPKHLPGLGGTDEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSANAPSSYPTLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPIKPPIYNSRLVSPSGSLGALSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQNNSKAAMNSSSGFNSSGPWYRWNHPTYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JMZ2</accession>
    <name>A0A9J7JMZ2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Differentially expressed in FDCP 8 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">Def8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11 12">17A/GY</strain>
            <tissue evidence="11 12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts (via C-terminus) with PLEKHM1; this interaction is weak but increased in a RAB7A-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEF8 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003495068.5"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007650769.4"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027410583.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="100759557"/>
    <dbReference type="KEGG" id="cge:100759557"/>
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    <dbReference type="OrthoDB" id="1918044at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="differentially expressed in FDCP 8 homolog isoform X2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
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    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00130">
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    </dbReference>
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    </dbReference>
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            <begin position="144"/>
            <end position="195"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00065704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027266383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027266384.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="53276" checksum="0F974A0F495492F6" modified="2023-06-28" version="1">MKGWDAMEYDEKLARFRQAHLNPFNKPIGSRQHEQEPSEKAQEVTSDETLPELPTGEPEFHYSERVMDLGLSEDHFSRPVGLFLASDVQQLRQAIEECKQVILELPEQSEKQKDAVVRLIHLRLKLQELKDPNEEEPNIRVLLEHRFYKEKSKSVKQTCDKCNTIIWGLIQTWYTCTGCYYRCHSKCLNLISKPCVSSKVSHQAEYELNICPETGLDSQDYRCAECRAPISLRGVPSEARQCDYTGQYYCSHCHWNDLAVIPARVVHNWDFEPRKVSRCSMRYLALMVSRPVLRLREINPLLFNYVEELVEIRKLRQDILLMKPYFITCKEAMEARLLLQLQDRQHFVENDEMYSIQDLLEVHMGRLSCSLTEIHTLFAKHIKLDCERCQAKGFVCELCKEGDVLFPFDSHTSVCTDCSAVFHRDCYYDNSTTCPKCARLNLRKQSLFQEPGLDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JP39</accession>
    <name>A0A9J7JP39_CRIGR</name>
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        <submittedName>
            <fullName evidence="14">LOW QUALITY PROTEIN: olfactory receptor 150 isoform X2</fullName>
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    <gene>
        <name evidence="14" type="primary">LOC100773460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027268056.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34088" checksum="4A09965FDE57DB31" modified="2023-06-28" version="1">MAERNDSAVTEFILSWLTDQPELHLPLFLLFLRIYLLTVLGNLGMIILILLSSHLHTPMYLFLSSLSFIDLCYSTVITPKMLVNFVKEKNVISYQECMTQLYFFLVFVISECHMLAAMAYDCYVAICNPLLCNVTMSYQVCSWMVGGIYCMGIICAAVHTLCMLRVVFCKTNIINHYLCDLFPLMEIACSNTFVNEVFLLGLRAFNILVSTLTILGSYIFIIASILHIKSTEGIFKAFSTCGSHFSAVAVFFGSLAFVYLQPSSVRSKDKGKVSSVFYTTIVPMLNPMIYSLRNRDVKTCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JRM8</accession>
    <name>A0A9J7JRM8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Parathyroid cell calcium-sensing receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC113830928</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027271853.1">
        <property type="nucleotide sequence ID" value="XM_027416052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JRM8"/>
    <dbReference type="GeneID" id="113830928"/>
    <dbReference type="KEGG" id="cge:113830928"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051924">
        <property type="term" value="P:regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vomeronasal 2, receptor 23"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vomeronasal 2, receptor 88"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
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    </dbReference>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
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        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
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        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF545">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 118-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
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    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="679"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="714"/>
            <end position="738"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="750"/>
            <end position="775"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="644"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027271853.1"/>
        </source>
    </evidence>
    <sequence length="916" mass="104480" checksum="4B13A313ECC4AB72" modified="2023-06-28" version="1">MNPYMLESESQVKVWREESNEEAIQNKQAVVMSATQTQAMVFSKVTVDHDEIIEVGKKEGWEMIHEMCLDKRNPTTYMNGDIILGAFIPIYVTQELQHQFLTPFKEKPNLFDAMIGKWKNYQYLLTLYFAIEEINKDAHLLPNVTLGFHLYNAFHTHRQTLEGLLMWLSERSEFIPNYKCKTQHKALGIIAGIRPEFSAAIGTLLELYKIPQVSFSLLLQITYGLFHSVLSDKDTFQSLYQISPQEKALTQGVIFLLLYFGWKWVGLIVADDIHGREFLSDLTAELASEDICVAFTETIPTYMKVDFLFEVGMVDLSQHTKVNVYVFYGDIDDVTIFYIENEIISKRKKMWIMAKPNFVYLQSVFYKWIGLMSFFEGSFSFSKKRNIPGFKHFIEALTPSQYPSDIYFHKFWLDNFHCSPSPLLCGGPELCPLNISLKNKQEIQVVMITSEPSVSIWNAVYAVAHALHEMLLSKTEIDSHKDINQDRLLPWQLHPFLRKIQFTNAAGDQICFDEKKNPMEKYDIQNFVGYTNHDSFVVKVGEFVSKSPQDKGLFINEVLIKWPSNFNQNPQSVCSESCGPGFWKLTEEGRPACCFSCVFCPERHISNQTDQQECIPCPIQEYPNPERNNCLPKSMTFLSLEDSLGLALVCVALCFSVSTAVVLGIFLKHQDSPIVKANNRTLSFILLISLLLCFLCSFLFIGQPSTASCILQQITFALVFTLLLSTVLAKTITVVLAFKVVKLGRTMRRLFVSGIYNSVIPICFLMQLILLGVWMGTSPPYIQADAHSEHSYIIILCNKGSVTAFYCVLAYLGILALGSFTVAFLARNLPDTFNESKFLTFSMLVFCSVWVTFLPVYHSTKNKAMVAVEVFSILASSAGLLGCIFIPKCYIILLRPDKNSLKCFKNKTKYRHNRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JTF9</accession>
    <name>A0A9J7JTF9_CRIGR</name>
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        <submittedName>
            <fullName evidence="6">Rho GTPase-activating protein 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Arhgap40</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027277042.1">
        <property type="nucleotide sequence ID" value="XM_027421241.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JTF9"/>
    <dbReference type="GeneID" id="100760450"/>
    <dbReference type="KEGG" id="cge:100760450"/>
    <dbReference type="CTD" id="343578"/>
    <dbReference type="OrthoDB" id="27680at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000018">
        <property type="entry name" value="Rho GTPase activating protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057323">
        <property type="entry name" value="RHG40/28/18_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25442">
        <property type="entry name" value="Ubiquitin_RHG40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="356"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00055252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027277042.1"/>
        </source>
    </evidence>
    <sequence length="705" mass="77737" checksum="3749CADFB36F3A06" modified="2023-06-28" version="1">MGVSWKGVPQALPPSSNSLRDSFSRRGSIGSLVCLSMTEPSLLPAAQMEGLALLPLASPCPRIPRARIARTPGRWAHLGCSPGPSIGPTNLQQRPLRPRPADCSHSRLSWAESLSMDGFWMEVERIQQKGEAKEEASGGSRSQLLEGDTESQWLQDTGLSGLVDGLGSDGDHQGLLSTLTQTQVAAVCRRLDTYARSARRRHKPPIRDVRDIFGVFTSRDVASENGASGMKWIQIHSVGSVSPVGATVPRDPQEPVGMEEVFNMDSAYSEQAAVLQRARRSPGGTCAWGKGSLPRFRVPKGRLGVTRIGDLSSRDMKKIPPLALIELTALYDILGLDLKRSKAGKWKGSDSGLFGVPLHSLLEADHRVLPSTQVPLLLQALLSCLEKRGLGTEGILRVPGSQARVKGLEQKLERDFYAGLVSWDKVHPNDASDLLKRFLRKLPAPLLTAEYLPAFAAVPNIPDLKQRLQALHLLVLLLPEPNRNTLKALLEFLRKVAAQEQRNKMTLWNVSTVMAPNLFLPRGRPPKLPRGEKQLAEGAAEVVCMMVQYQDMLWTVASFLVAQVRKLNDSNGRRSQLCDGGLKTWLRRTHVDRDKDGDRLEATPKVAKIQVTWPSMDLLQVPLNPSTRVTHILKLFMERLNPGSQPEEGSEDPGSILSDNTKLVNFLVYEVGGNIDEHRLDPDAYLLDLYRANPHGDWVIRQSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JX47</accession>
    <name>A0A9J7JX47_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">INO80 complex subunit B isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ino80b</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027285208.1">
        <property type="nucleotide sequence ID" value="XM_027429407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JX47"/>
    <dbReference type="GeneID" id="100764793"/>
    <dbReference type="KEGG" id="cge:100764793"/>
    <dbReference type="CTD" id="83444"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23021">
        <property type="entry name" value="zf-HIT_IN80B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="232"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027285208.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="40967" checksum="4C250F122A40BE06" modified="2023-06-28" version="1">MSACVPTVSSPLPLQDPMSKLWRRGSTSGAMEAPEPGSPSSGEALELSLTGAHSHGVHKKKHKKHKKKHKKKHHQEEEAGQTQAPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLPGDLEGQEEEEEQRWLDALEKGELDDNGDLKKEIDERLLTARQRALLQKARSQPSPILPLPVAGGCPAPALTEEMLLKREERARKRRLQAARRAEEHKNQTIERLTKTAAPSGRGGRGAARGERRGGRTAAPAPTPMVRYSSGAQGSTLSFPPGVPAPAAVAQRPAPSNPAPRCSVPGCPHPRRYACSRTGQALCSLQCYRINLQLRLGGPEGPGSPLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JZU5</accession>
    <name>A0A9J7JZU5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate-rich protein 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Erich2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035302744.1">
        <property type="nucleotide sequence ID" value="XM_035446853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JZU5"/>
    <dbReference type="GeneID" id="100773190"/>
    <dbReference type="KEGG" id="cge:100773190"/>
    <dbReference type="CTD" id="285141"/>
    <dbReference type="OrthoDB" id="9950633at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026703">
        <property type="entry name" value="ERICH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035302744.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="48165" checksum="BB0703906DF601AF" modified="2023-06-28" version="1">MDTDLPVPLSPGFLKVTRVRAQVCPRMCAPNLPRSVNPRPSGRWATRAPRPALSVVPTAGPVPAPPPAHALRPARGPPRSAPLAPPLRHTALSLGGSRGSRGSSRSPSCLHGDAASQVRNSEPSARGERGWPSWSALRGISFAGPPAGWASGAPRLPRHRPRSLGPEFCIPEIPRNYLDKKDIIKAPKSRQNGTLLVFDPKEKVMIGPNKSLSQKCCFVRRPRLASKLYSSPTQISLGVANKFSAKKEASSKKMEDKVSFKSTENRPSSRSIKKKDVLTSWQSDLWSSSFLTEIAGEAGKDAILGKQDKSSEYFLEDIEEKLSDSTDGDGDDDTNDDDDEGPTKKETRAPLELMAEFLRAEMGRDYQLAKKLCQMILIYEPENPVAKEFFSLIEEILLKEKAQKHEEDDEDSEEDTSSESEAESSEDASDDSSDECEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K245</accession>
    <name>A0A9J7K245_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYN-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Activation-dependent, raft-recruited ADAP-like phosphoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Fyb2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with SKAP1, LCK and FYN. The phosphorylated form interacts with LCP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035294560.1">
        <property type="nucleotide sequence ID" value="XM_035438669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K245"/>
    <dbReference type="GeneID" id="100767623"/>
    <dbReference type="KEGG" id="cge:100767623"/>
    <dbReference type="CTD" id="199920"/>
    <dbReference type="OrthoDB" id="5986624at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000220">
        <property type="entry name" value="FYN binding protein 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYB1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029294">
        <property type="entry name" value="hSH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16830:SF1">
        <property type="entry name" value="FYN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16830">
        <property type="entry name" value="SH2 CONTAINING ADAPTOR PRAM-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14603">
        <property type="entry name" value="hSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="687"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="433"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="480"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="615"/>
            <end position="654"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="544"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <dbReference type="ARBA" id="ARBA00004285"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    <evidence type="ECO:0000313" key="13">
        <source>
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    <sequence length="745" mass="83387" checksum="FEF4FD56B75EBC31" modified="2023-06-28" version="1">MLPELKIVSGTLRRLTLQPQPLTLGATEGVKTFKELRAKFQKYDAPPFPGPIKFSAGVSRKDDRGHPQPAQSLASSNNLSSHHHRPLSYSLTEVSKPLKSQKMKLAQKGEIQKNSSSSGPPGKSAECPARNSQKAAMPLDASKPKAGTPNEEKGMNVSSFRYKLWNWEKFSSQKSEISPASPLTNCGSRTFHLEGQKTMGSVQIKPEKSPEATGVQTLPPQSHLMVQRTSPVAPEASPLPLPQHDRKETDSPNAEESPTSSLCQPVYECELTIPVPEKPESRRHQLPKTKPLPSIETLGPPPPKPSKPPFVNLQAFQRQPTVVSKTLKEVTVKEGPLPPEGAELEEPHNYDTRISYLSHSSNSINLCAAGETAEATYEIEIEELQKPWRSFPHLEPRPTLKDEENSMQEKESYELEPPKPEDSHPKHPSKVGVYEETPGKVQMAGVQGDRWSLPAGNQEAVVDINQNKLFPEDVVLTRHSQEKGGYVEALEVTKETPSSSTTRSDSSSEKTYDDVGCSREELPKWDFSSSFTSDSEDNSEEMYEDIYKAKNNDQKPEVDGRAALRRLQQLFGKEKGIFRMRKTKSKENVSNGFSMSLPDLGLRSQDVIIYDDVDTSDKESKDEDKPKTWKPKFLTSKGKRGKKSSDGSKSFSPKNFFRAKKHNLEKNRMEKEEKLFRERFQYGKEIVVINRAVACSSNSRNGIFDLPITPGEQLEVIDTTEQNLVICRNSKGKYGYVLIEHLHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3GZP5</accession>
    <name>G3GZP5_CRIGR</name>
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        <recommendedName>
            <fullName evidence="15">UBX domain-containing protein 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 23 24 25" type="primary">Ubxn2a</name>
        <name evidence="19" type="ORF">I79_003337</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23 24 25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23 24 25">17A/GY</strain>
            <tissue evidence="23 24 25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons. Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation. Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9. Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Part of a complex composed of STUB1/CHIP, VCP/p97, CHRNA3, and UBXN2A that modulates the ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of CHRNA3. Within the complex UBXN2A acts as a scaffold protein required for the interaction of CHRNA3 with VCP/p97, this interaction also inhibits CHRNA3 ubiquitination by STUB1/CHIP and subsequently ERAD. Interacts (via SEP domain) with CHRNA3 and interacts (via UBX domain) with VCP/P97; these interactions are required for the interaction of CHRNA3 with the STUB1-VCP-UBXN2A complex. Interacts with HSPA9/MOT-2 (via SBD domain); the interaction inhibits HSPA9/MOT-2 interaction with and degradation of p53, thereby promotes p53 translocation to the nucleus. Interacts with RICTOR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000081">
        <property type="protein sequence ID" value="EGV91882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280393.1">
        <property type="nucleotide sequence ID" value="XM_027424592.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280394.1">
        <property type="nucleotide sequence ID" value="XM_027424593.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280396.1">
        <property type="nucleotide sequence ID" value="XM_027424595.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298452.1">
        <property type="nucleotide sequence ID" value="XM_035442561.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298455.1">
        <property type="nucleotide sequence ID" value="XM_035442564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GZP5"/>
    <dbReference type="STRING" id="10029.G3GZP5"/>
    <dbReference type="PaxDb" id="10029-XP_007636585.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008709.1">
        <property type="protein sequence ID" value="ENSCGRP00001005638.1"/>
        <property type="gene ID" value="ENSCGRG00001007449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761536"/>
    <dbReference type="KEGG" id="cge:100761536"/>
    <dbReference type="CTD" id="165324"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000055567"/>
    <dbReference type="OMA" id="SRCQRSC"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033130">
        <property type="term" value="F:acetylcholine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904293">
        <property type="term" value="P:negative regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031396">
        <property type="term" value="P:regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17160">
        <property type="entry name" value="UBX_UBXN2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000164">
        <property type="entry name" value="UBX domain-containing protein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000004">
        <property type="entry name" value="UBX domain-containing protein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
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            <taxon>Myomorpha</taxon>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV96457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027265834.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26094" checksum="203ED4D6C9ED4192" modified="2011-11-16" version="1">MPAPLETCLSDLDCASSNSSSDLSKFLTDEEDCARLQPLASTSGLSVPARRSAPTISNVPGAQDEEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCAPCLPGPPSPASDAESWGSGAASSPCATVASPLSDPSSPSAPDDFTYGPGDPLFSFPGLPKDLLHTTPCFIPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3H8N2</accession>
    <name>G3H8N2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2 7 8">snRNA-activating protein complex subunit 5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5 6 9">snRNA-activating protein complex subunit 5-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">Snapc5</name>
        <name evidence="5 6 9" type="synonym">LOC113835540</name>
        <name evidence="2" type="ORF">I79_006737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5 6 7">17A/GY</strain>
            <tissue evidence="5 6 7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000217">
        <property type="protein sequence ID" value="EGW04310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003500528.1">
        <property type="nucleotide sequence ID" value="XM_003500480.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270578.1">
        <property type="nucleotide sequence ID" value="XM_027414777.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270579.1">
        <property type="nucleotide sequence ID" value="XM_027414778.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027290127.1">
        <property type="nucleotide sequence ID" value="XM_027434326.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027290128.1">
        <property type="nucleotide sequence ID" value="XM_027434327.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299654.1">
        <property type="nucleotide sequence ID" value="XM_035443763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H8N2"/>
    <dbReference type="STRING" id="10029.G3H8N2"/>
    <dbReference type="PaxDb" id="10029-XP_007610221.1"/>
    <dbReference type="GeneID" id="100755752"/>
    <dbReference type="KEGG" id="cge:100755752"/>
    <dbReference type="CTD" id="10302"/>
    <dbReference type="eggNOG" id="ENOG502S8MI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H8N2"/>
    <dbReference type="OMA" id="EDPPNIM"/>
    <dbReference type="OrthoDB" id="6158499at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029138">
        <property type="entry name" value="SNAPC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15333">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15333:SF2">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15497">
        <property type="entry name" value="SNAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW04310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027270578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027270579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027290127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027290128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035299654.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11217" checksum="C0D1581340402033" modified="2011-11-16" version="1">MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGTEMLSSQPAPEQLYDMSVHVDNEASINQTTLKLSTRSPMEEEEEEEEEESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3HAC7</accession>
    <name>G3HAC7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEC14 domain and spectrin repeat-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Huntingtin-interacting protein-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12 13" type="primary">Sestd1</name>
        <name evidence="8" type="ORF">I79_007375</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13">17A/GY</strain>
            <tissue evidence="12 13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SOLO family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000248">
        <property type="protein sequence ID" value="EGW08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003501074.1">
        <property type="nucleotide sequence ID" value="XM_003501026.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275895.1">
        <property type="nucleotide sequence ID" value="XM_027420094.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275896.1">
        <property type="nucleotide sequence ID" value="XM_027420095.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HAC7"/>
    <dbReference type="STRING" id="10029.G3HAC7"/>
    <dbReference type="PaxDb" id="10029-XP_007613465.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016692.1">
        <property type="protein sequence ID" value="ENSCGRP00001012458.1"/>
        <property type="gene ID" value="ENSCGRG00001013863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767556"/>
    <dbReference type="KEGG" id="cge:100767556"/>
    <dbReference type="CTD" id="91404"/>
    <dbReference type="eggNOG" id="KOG4240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111148"/>
    <dbReference type="OMA" id="PDAFWDK"/>
    <dbReference type="OrthoDB" id="5859883at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904878">
        <property type="term" value="P:negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000124">
        <property type="entry name" value="SEC14 domain and spectrin repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000187">
        <property type="entry name" value="SEC14 domain and spectrin repeat-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056804">
        <property type="entry name" value="Spectrin_SESTD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46607">
        <property type="entry name" value="SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46607:SF1">
        <property type="entry name" value="SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24915">
        <property type="entry name" value="Spectrin_SESTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW08607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027275895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027275896.1"/>
        </source>
    </evidence>
    <sequence length="696" mass="79318" checksum="731D7845DC44E1DC" modified="2011-11-16" version="1">MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGSEQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDASQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEALNDEEQFEEIEAVGKSLLDRLTVPVVYPDGTEQYFGSPSDMASTAEHIRDRMKLVSLKRQQLRHPEMVTAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3HMF2</accession>
    <name>G3HMF2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial import receptor subunit TOM5 homolog</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Mitochondrial import receptor subunit TOM5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Tomm5</name>
        <name evidence="10" type="ORF">I79_011912</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000508">
        <property type="protein sequence ID" value="EGV92195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504845.1">
        <property type="nucleotide sequence ID" value="XM_003504797.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258981.1">
        <property type="nucleotide sequence ID" value="XM_027403180.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HMF2"/>
    <dbReference type="STRING" id="10029.G3HMF2"/>
    <dbReference type="PaxDb" id="10029-XP_007637697.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031753.1">
        <property type="protein sequence ID" value="ENSCGRP00001027506.1"/>
        <property type="gene ID" value="ENSCGRG00001024499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751863"/>
    <dbReference type="KEGG" id="cge:100751863"/>
    <dbReference type="CTD" id="401505"/>
    <dbReference type="eggNOG" id="ENOG502S99E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QIYCSSE"/>
    <dbReference type="OrthoDB" id="8893106at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029179">
        <property type="entry name" value="TOMM5_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28436">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28436:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV92195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027258981.1"/>
        </source>
    </evidence>
    <sequence length="51" mass="6051" checksum="43F104D78754B0FE" modified="2011-11-16" version="1">MFRIEGLAPKLDPEEMKRKMREDVISSIRNFLIYVALLRVTPYILKKLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3HWH4</accession>
    <name>G3HWH4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Villin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Vil1</name>
        <name evidence="17" type="ORF">I79_015332</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Filopodium tip</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000831">
        <property type="protein sequence ID" value="EGW11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296923.1">
        <property type="nucleotide sequence ID" value="XM_035441032.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315173.1">
        <property type="nucleotide sequence ID" value="XM_035459282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HWH4"/>
    <dbReference type="STRING" id="10029.G3HWH4"/>
    <dbReference type="PaxDb" id="10029-XP_007614279.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028721.1">
        <property type="protein sequence ID" value="ENSCGRP00001024475.1"/>
        <property type="gene ID" value="ENSCGRG00001022375.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773155"/>
    <dbReference type="KEGG" id="cge:100773155"/>
    <dbReference type="CTD" id="7429"/>
    <dbReference type="eggNOG" id="KOG0443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160544"/>
    <dbReference type="OMA" id="EPASFWV"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035727">
        <property type="term" value="F:lysophosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035729">
        <property type="term" value="P:cellular response to hepatocyte growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060327">
        <property type="term" value="P:cytoplasmic actin-based contraction involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001951">
        <property type="term" value="P:intestinal D-glucose absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000394">
        <property type="term" value="P:positive regulation of lamellipodium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032532">
        <property type="term" value="P:regulation of microvillus length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061041">
        <property type="term" value="P:regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902896">
        <property type="term" value="P:terminal web assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000001">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000004">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000005">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000027">
        <property type="entry name" value="Villin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.950.10:FF:000005">
        <property type="entry name" value="Villin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000035">
        <property type="entry name" value="Villin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF35">
        <property type="entry name" value="VILLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="16">
        <location>
            <begin position="761"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035296923.1"/>
        </source>
    </evidence>
    <sequence length="827" mass="92861" checksum="2F368417458C4BAF" modified="2011-11-16" version="1">MTKLTTQVKGSLNTTTPGLQIWRIEAMQMVPVPSSSFGNFFDGDCYVVLAIHKTSSTLTYDIHYWIGQNSSQDEQGAAAIYTTQMDDYLKGRAVQHREVQGNESETFRGHFKQGLVIQKGGVASGMKHVETNSCDVQRLLHVKGKRNVMAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESNRMERLRGMTLAKEIRDQERGGRTYVGVVDGESEGDSPQLMAIMNHVLGKRKELKAAISDSVVEPAVKAALKLYHVSDSEGNLVVREVATRPLTQDLLRHEDCYILDQGGVKIFVWKGKNANEQERKGAMSQALNFIKAKQYPPSTQVEVQNDGAESAIFQQLFQKWTVPNRTSGLGKTHTVGSVARVEQVKFDAMSMHVQPQVAAQQKMVDDGSGEVQVWRIEDLELVPVDSKWLGHFYGGDCYLLLYTYLIGEKEHYLLYIWQGSQASQDEIAASAYQAVILDQKYNDEPVQIRVTMGKEPPHLMSIFKGRMVVYQGGTSRDNNLEPVPSTRLFQVRGTSANNTKAFEVTARATSLNSNDVFILKTPSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYCSTKRLQEENQVITPRLFECSNQTGRFMATEIFDFNQDDLEEDDVFLLDVWDQVFFWIGKHAKEEEKKAAAITVQEYLKTHPGNRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWTNVKSYDDLKAELGNSGDWGQLADEVMNPKADRFTASTSLSSGPLPIFPLEQLVNKPAEELPEGVDPSRKEEHLSIEDFTKALGMTPAAFSALPRWKQQNLKKEKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3HY04</accession>
    <name>G3HY04_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione transferase</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">LOC100765453</name>
        <name evidence="10" type="ORF">I79_015929</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JH000899">
        <property type="protein sequence ID" value="EGW12153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003508143.1">
        <property type="nucleotide sequence ID" value="XM_003508095.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250024.1">
        <property type="nucleotide sequence ID" value="XM_027394223.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HY04"/>
    <dbReference type="STRING" id="10029.G3HY04"/>
    <dbReference type="PaxDb" id="10029-XP_007619964.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007151.1">
        <property type="protein sequence ID" value="ENSCGRP00001004731.1"/>
        <property type="gene ID" value="ENSCGRG00001006075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765453"/>
    <dbReference type="KEGG" id="cge:100765453"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156366"/>
    <dbReference type="OMA" id="AKGAHKQ"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03183">
        <property type="entry name" value="GST_C_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03050">
        <property type="entry name" value="GST_N_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000008">
        <property type="entry name" value="Glutathione S-transferase theta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000086">
        <property type="entry name" value="Glutathione S-transferase theta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040077">
        <property type="entry name" value="GST_C_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040075">
        <property type="entry name" value="GST_N_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051369">
        <property type="entry name" value="GST_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917:SF12">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE THETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGW12153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027250024.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27557" checksum="D58DC8C204C03341" modified="2011-11-16" version="1">MGLELYLDLMSQPCRAVYIFAKKNDIPFQLRTIELLKGQHYTDDFAQVNPLRKVPALKDGDFILAESVAILLYLSRKYKAPDHWYPQDLQARARVDEYLSWQHTALRSCCTRAMWQKMMFPKYLGQPVAPETLAATLAELDRCLQMLEDKFLQNQAFLTGSHISVADLVAVTELMHPVSAGCKIFESRPKLAAWRQRVEAVVGEKLFQEAHAVVLKAKDMPPLMDPTLKEKLKLSLQCLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3IA45</accession>
    <name>G3IA45_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-3-methyladenine glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-alkyladenine DNA glycosylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">3-methyladenine DNA glycosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">ADPG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">N-methylpurine-DNA glycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Mpg</name>
        <name evidence="17" type="ORF">I79_020461</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.</text>
            <dbReference type="EC" id="3.2.2.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Binds MBD1. Binds SSBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
            <location evidence="3">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.21" evidence="5"/>
    <dbReference type="EMBL" id="JH001669">
        <property type="protein sequence ID" value="EGW10378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511893.1">
        <property type="nucleotide sequence ID" value="XM_003511845.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280958.1">
        <property type="nucleotide sequence ID" value="XM_027425157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IA45"/>
    <dbReference type="STRING" id="10029.G3IA45"/>
    <dbReference type="PaxDb" id="10029-XP_007609363.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020300.1">
        <property type="protein sequence ID" value="ENSCGRP00001016056.1"/>
        <property type="gene ID" value="ENSCGRG00001016501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758892"/>
    <dbReference type="KEGG" id="cge:100758892"/>
    <dbReference type="CTD" id="4350"/>
    <dbReference type="eggNOG" id="KOG4486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009825"/>
    <dbReference type="OMA" id="VEAYHHT"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:mitochondrial nucleoid"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative 3-methyladenine DNA glycosylase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="entry name" value="Methylpurine-DNA glycosylase (MPG)"/>
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        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429:SF0">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002421"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012000"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023271"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033426"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068926"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
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            <dbReference type="EMBL" id="EGW10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016056.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
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            <dbReference type="RefSeq" id="XP_027280958.1"/>
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</entry>
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    <name>G3IAV3_CRIGR</name>
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        <recommendedName>
            <fullName evidence="6">Transcription factor 21</fullName>
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    </protein>
    <gene>
        <name evidence="10 13" type="primary">Tcf21</name>
        <name evidence="9" type="ORF">I79_020735</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH001759">
        <property type="protein sequence ID" value="EGW13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512108.1">
        <property type="nucleotide sequence ID" value="XM_003512060.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258727.1">
        <property type="nucleotide sequence ID" value="XM_027402926.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IAV3"/>
    <dbReference type="STRING" id="10029.G3IAV3"/>
    <dbReference type="PaxDb" id="10029-XP_007632073.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028152.1">
        <property type="protein sequence ID" value="ENSCGRP00001023906.1"/>
        <property type="gene ID" value="ENSCGRG00001021984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769038"/>
    <dbReference type="KEGG" id="cge:100769038"/>
    <dbReference type="CTD" id="6943"/>
    <dbReference type="eggNOG" id="KOG4029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEGACAN"/>
    <dbReference type="OrthoDB" id="6233288at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
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    <dbReference type="GO" id="GO:0070888">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
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    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0014707">
        <property type="term" value="P:branchiomeric skeletal muscle development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060435">
        <property type="term" value="P:bronchiole development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060539">
        <property type="term" value="P:diaphragm development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:epithelial cell differentiation"/>
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        <property type="term" value="P:lung alveolus development"/>
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        <property type="term" value="P:lung morphogenesis"/>
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    </dbReference>
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        <property type="term" value="P:lung vasculature development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:metanephric glomerular capillary formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072162">
        <property type="term" value="P:metanephric mesenchymal cell differentiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0060766">
        <property type="term" value="P:negative regulation of androgen receptor signaling pathway"/>
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        <property type="term" value="P:reproductive structure development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007530">
        <property type="term" value="P:sex determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19704">
        <property type="entry name" value="bHLH_TS_TCF21_capsulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF67">
        <property type="entry name" value="TRANSCRIPTION FACTOR 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027258727.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19701" checksum="17485E78DA08ABAC" modified="2011-11-16" version="1">MSTGSLSDVEDLQEMEMLDCDSLKVDSNKEFVTSNESTEEGSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPESDLKEVVTASRLCGTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3ICD4</accession>
    <name>G3ICD4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hyaluronan and proteoglycan link protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Hapln3</name>
        <name evidence="16" type="ORF">I79_021327</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May function in hyaluronic acid binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HAPLN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH001911">
        <property type="protein sequence ID" value="EGW13738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512580.1">
        <property type="nucleotide sequence ID" value="XM_003512532.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263984.1">
        <property type="nucleotide sequence ID" value="XM_027408183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ICD4"/>
    <dbReference type="PaxDb" id="10029-XP_007628532.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008548.1">
        <property type="protein sequence ID" value="ENSCGRP00001005543.1"/>
        <property type="gene ID" value="ENSCGRG00001007307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763907"/>
    <dbReference type="KEGG" id="cge:100763907"/>
    <dbReference type="CTD" id="145864"/>
    <dbReference type="eggNOG" id="ENOG502QWFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159628"/>
    <dbReference type="OMA" id="AHPRPNC"/>
    <dbReference type="OrthoDB" id="6431884at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05877">
        <property type="entry name" value="Ig_LP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03518">
        <property type="entry name" value="Link_domain_HAPLN_module_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03519">
        <property type="entry name" value="Link_domain_HAPLN_module_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000845">
        <property type="entry name" value="Hyaluronan and proteoglycan link protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000001">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000002">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050691">
        <property type="entry name" value="Hyaluronan_bind_Proteoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804">
        <property type="entry name" value="AGGRECAN/VERSICAN PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804:SF40">
        <property type="entry name" value="HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0373">Hyaluronic acid</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732376" description="Hyaluronan and proteoglycan link protein 3" evidence="13">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="15">
        <location>
            <begin position="166"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="15">
        <location>
            <begin position="266"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="286"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW13738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027263984.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40836" checksum="9AA40BC0ACF4DF1F" modified="2011-11-16" version="1">MGLLFLVLLLSLSCVMGLPFSNGFYYSNGLHSRTLGHGYGEGLFNGVKLVVETTEESLFSHRGASVTLPCHYRYEPALASPRHVRVKWWKLSENGSPEQDVLVAIGQRHRSFGNYQGRVQLRQGKQQEVSLELRDLRPEDSGRYRCEVIDGLEDESGLVELELRGVVFPYQPREGRYQLNFHEAQKACQEQDAVVASFEQLFRAWEEGLDWCNAGWLQDASVQYPIALPRQPCGGLGLAPGVRSYGQRHHRLHRYDVFCFTAVLRGWVYYLEHPRKLTLLEAREACQEDGAQISTVGQLFAAWKFRGLDRCDAGWLADGSARYPIVHPRPNCGPPEPGVRTFGFPDPHSRYGVYCYRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>G3ICR5</accession>
    <name>G3ICR5_CRIGR</name>
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        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 20" type="primary">LOC100756004</name>
        <name evidence="15" type="ORF">H671_3g11252</name>
        <name evidence="14" type="ORF">I79_021464</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001946">
        <property type="protein sequence ID" value="EGW13580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE673552">
        <property type="protein sequence ID" value="ERE77210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512699.1">
        <property type="nucleotide sequence ID" value="XM_003512651.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260813.1">
        <property type="nucleotide sequence ID" value="XM_027405012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ICR5"/>
    <dbReference type="STRING" id="10029.G3ICR5"/>
    <dbReference type="PaxDb" id="10029-XP_007635510.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012363.1">
        <property type="protein sequence ID" value="ENSCGRP00001008247.1"/>
        <property type="gene ID" value="ENSCGRG00001010562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756004"/>
    <dbReference type="KEGG" id="cge:100756004"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282496"/>
    <dbReference type="OMA" id="CVIQIIA"/>
    <dbReference type="OrthoDB" id="2101615at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15237">
        <property type="entry name" value="7tmA_OR2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000005">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW13580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE77210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008247.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027260813.1"/>
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    </evidence>
    <sequence length="314" mass="35396" checksum="238F8090144BA813" modified="2011-11-16" version="1">MGRENQTFVDEFLLLGLAQDAQTQILLFVLFFIIYVLTILGNLLIIILIFMDSQLHTPMYFFLRNLSFADLCLSNSIVPQVLSHFLAKRKTISFWGCVIQIIATLQIGCTECALLAVMSYDRYVAVCKPLHYSTIMTQQLCLQLALGSWASGLLVSLIDISVAFHLPYKGQNTVSHYFCEIPALLKVASADTYSTEMVIFALGIVILLAPVSLILISYWNIISTVIQMRSEEGRLKVFSTCGSHLVVVVLFYGSGIFNYMQPNTKTTKKRDKIISVFYTVVTPMLNPIIYSLRNKDVKGAFRKLAARMSFLHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3ICV2</accession>
    <name>G3ICV2_CRIGR</name>
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        <submittedName>
            <fullName evidence="14 15 18 19 20">Zinc finger protein 217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18 19 20 21 22 23" type="primary">Znf217</name>
        <name evidence="14" type="ORF">I79_021506</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19 20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19 20">17A/GY</strain>
            <tissue evidence="18 19 20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001964">
        <property type="protein sequence ID" value="EGW13080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651298.1">
        <property type="nucleotide sequence ID" value="XM_007653108.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651300.1">
        <property type="nucleotide sequence ID" value="XM_007653110.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651302.1">
        <property type="nucleotide sequence ID" value="XM_007653112.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027240446.1">
        <property type="nucleotide sequence ID" value="XM_027384645.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279097.1">
        <property type="nucleotide sequence ID" value="XM_027423296.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279098.1">
        <property type="nucleotide sequence ID" value="XM_027423297.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279099.1">
        <property type="nucleotide sequence ID" value="XM_027423298.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279102.1">
        <property type="nucleotide sequence ID" value="XM_027423301.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279104.1">
        <property type="nucleotide sequence ID" value="XM_027423303.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279105.1">
        <property type="nucleotide sequence ID" value="XM_027423304.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ICV2"/>
    <dbReference type="STRING" id="10029.G3ICV2"/>
    <dbReference type="GlyGen" id="G3ICV2">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007623709.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003148.1">
        <property type="protein sequence ID" value="ENSCGRP00001002400.1"/>
        <property type="gene ID" value="ENSCGRG00001002600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772974"/>
    <dbReference type="KEGG" id="cge:100772974"/>
    <dbReference type="CTD" id="7764"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159884"/>
    <dbReference type="OrthoDB" id="8953863at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001038">
        <property type="entry name" value="Zinc finger protein 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001201">
        <property type="entry name" value="Zinc finger protein 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001441">
        <property type="entry name" value="Zinc finger protein 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051967">
        <property type="entry name" value="Krueppel_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925:SF4">
        <property type="entry name" value="ZINC FINGER PROTEIN 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="734"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="801"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW13080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027279097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027279098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027279099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027279102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027279104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027279105.1"/>
        </source>
    </evidence>
    <sequence length="1046" mass="113963" checksum="8A6A4D354BADE45D" modified="2011-11-16" version="1">MPTQSLLMYMDGPEVIGSSLGTQMEVDDAVSIKGPAAVPFRAAPERSMTPAEGHMPLDCMFCSQAFSHAEDLNQHVLTQHRPTLCEPAVLRVEAEYLSPLDKGQVPAEPPKEKNCKENEELSCDVCGQTFPGAFDVESHMKKHKDSFTYGCSMCGRRFKEPWFLKNHMRTHNGKSGTRSKLQQSLESPVTINEVVQAHVAGSVSTPYKICMVCGFLFPNKQSLIEHSKVHAKETASSATSTTPDAQQEEGPMPPREELLQFLNLRPVSHLETTAKPITCIPQLDPFTTYQAWQLATKGKVAIAQEEVKESGQEGSTDNDDSCSEKEELGEIWIGNKSEGSGKSKTNRSSCPGLSQDKEKPRHANSEVPSGDGDPKVPSSKEKPTHCSECSKAFRTYHQLVLHSRVHKKDRRADAPSPTMSVDGRQPGTCSPDLATTLEDSGTVDREGGSEDGSEDGLPEGLHLDKNDDGGKAKPLTSSRECSYCGKFFRSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTSLRYHLERHHKDKQLVDAAAEVKSEGRSQEPQEALLTADSVQTKNLKRFLDGAKDVKGNPSAKQLKEMPSVFQSVLGSTVLSPAHKDTQDFHKHTADDGEKVRKSPAPAYLDMTKKRAAGEPQASSPACKLEGAGPLAREAAHREKMEWEADCKYKPGADCQDSPLNLSLGPLHASPAITLNKCLIPSISCPFCTFKTFYPEVLLMHQRLEHRWHPDTPKNCGKSVSRSRRTGCPPALLGKDVPPLSGPHKPKVKPAFSSQAKSLHPEKVRQGSSGPGKAPQTSGPDSSTLAPSNLKSHRSQPSTGGPGATRQQQSDLFPKGGSVSAAADKVKRPEPKLKAPPTAPSQSPLGSSNGNGSIEYSVKVDGPWVPQGRDYYCHRNAGSATAEFTEPHPKRLKSSVMALDTEHSGPNGRRGFELPKYHVARSITSLLPSECVRPSPVLLPKARFLSPGEVESPSVLTVQKPYSTSGPLYNCGPVGHAGASPTLEGKRPVSYQQLSSSMLQKRSYENCIGNTHHRPNDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3IEE1</accession>
    <name>G3IEE1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHF complex subunit HOOK-interacting protein 1B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">FTS- and Hook-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">Fam160a2</name>
        <name evidence="12" type="synonym">Fhip1b</name>
        <name evidence="11" type="ORF">H671_3g9014</name>
        <name evidence="10" type="ORF">I79_022088</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16 17">17A/GY</strain>
            <tissue evidence="16 17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002186">
        <property type="protein sequence ID" value="EGV99815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE671487">
        <property type="protein sequence ID" value="ERE80213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513214.1">
        <property type="nucleotide sequence ID" value="XM_003513166.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260727.1">
        <property type="nucleotide sequence ID" value="XM_027404926.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260728.1">
        <property type="nucleotide sequence ID" value="XM_027404927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IEE1"/>
    <dbReference type="STRING" id="10029.G3IEE1"/>
    <dbReference type="GlyGen" id="G3IEE1">
        <property type="glycosylation" value="3 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007612364.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010297.1">
        <property type="protein sequence ID" value="ENSCGRP00001006540.1"/>
        <property type="gene ID" value="ENSCGRG00001008833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752778"/>
    <dbReference type="KEGG" id="cge:100752778"/>
    <dbReference type="CTD" id="84067"/>
    <dbReference type="eggNOG" id="KOG3695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182936"/>
    <dbReference type="OMA" id="QQTHTEC"/>
    <dbReference type="OrthoDB" id="6287422at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070695">
        <property type="term" value="C:FHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905719">
        <property type="term" value="P:protein localization to perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF4">
        <property type="entry name" value="FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="9">
        <location>
            <begin position="757"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="588"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV99815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ERE80213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027260727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027260728.1"/>
        </source>
    </evidence>
    <sequence length="990" mass="107976" checksum="684E2C0A266EB74B" modified="2011-11-16" version="1">MEKMNWLSRLASRVPGHRVPQGASLQTPVMADPETCLMVFKNHWSQVVRILERQSPRAAAGGADDLSAVRNHTYQMITLLAEDRAVPSAPAGPGPLLEFALREDLLSRVLTWQLQWDEFGDGVEERRAEQLKLFEMLVSEARQPLLRHGPVREALLALLDACGRPVPSSPALDEGLVLLLSQLCVCVAREPSLLEFFLQPPPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALLLLMALSDGSPTVGRYIADHSYFCPVLATGLSALYSSLPRKIEVPGDDWHCLRREDWIGVPALALFMSSLEFCNAVIQVAHPLVQKQLVDYIHNGFLVPVMGPALHKTSVEEMIASTAYLELFLRSISEPALLRTFLRFLLLHRHDTHTILDTLVARIGSNSRLCMVSLSLFRTLLNLSCEDVLLQLVLRYLVPCNHVMLSQKPAVRDVDLYGRAADKFLSLIPRCCRHHAPSPPRPEHASWARGGPSRETGRREDITGPGSPSVDSSSSVVTMPRPSTPSRLALFLRQQSLGGSESPGPAPRSPGLTASPTSSPGRRPSPAEESGELEDNYLEYLREARRGVDCCVRACRTWSAPYDGERPPPEPNLFGSRTKKRSLLPEEDRDNVGEGEEENPGNRGLAVGVGDTPGHLPLPQLNGVPGPWPEGAKKVRLVPRLVPQEGVRELLECTSEGMAGLESFGQELRELEVALSNGGAGSEPPLEPPLPPEEEEAYESFTSPPEPPGPFLSSPLRTLHQLPSQPFTGPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQPSVKSLLQVLGSVKNKIESFAASQEDFPALLSKAKKYLIARGKLDWAEGPTAGSAPRRSDSLVRSRRPSLGELLLRHAHSPTRARQAAQVLQPGREGTGLGLGGGSPGASTPVLLPRGGVSERQGEALRVKNAVYCAVIFPEFLKELAAISQAHAVTSPFLLDTSEEVSIPPISGFGPLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G3IFY1</accession>
    <name>G3IFY1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">Tyms</name>
        <name evidence="14" type="ORF">H671_2g7347</name>
        <name evidence="13" type="ORF">I79_022656</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12105"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="EMBL" id="JH002476">
        <property type="protein sequence ID" value="EGW14385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE669711">
        <property type="protein sequence ID" value="ERE82571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513691.1">
        <property type="nucleotide sequence ID" value="XM_003513643.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254759.1">
        <property type="nucleotide sequence ID" value="XM_027398958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IFY1"/>
    <dbReference type="STRING" id="10029.G3IFY1"/>
    <dbReference type="PaxDb" id="10029-XP_007635813.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008935.1">
        <property type="protein sequence ID" value="ENSCGRP00001005772.1"/>
        <property type="gene ID" value="ENSCGRG00001007642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754276"/>
    <dbReference type="KEGG" id="cge:100754276"/>
    <dbReference type="CTD" id="7298"/>
    <dbReference type="eggNOG" id="KOG0673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000007">
        <property type="entry name" value="thymidylate synthase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW14385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE82571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005772.1"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027254759.1"/>
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    </evidence>
    <sequence length="307" mass="34826" checksum="27A97B1E408FA572" modified="2011-11-16" version="1">MPVVGSKLHSAAQQQGAEAPRHGELQYLGQVEHIMRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVENGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="protein sequence ID" value="EGW08952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_035437649.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035438852.1"/>
    </dbReference>
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    <dbReference type="STRING" id="10029.G3IH69"/>
    <dbReference type="PaxDb" id="10029-XP_007624272.1"/>
    <dbReference type="GeneID" id="100750740"/>
    <dbReference type="KEGG" id="cge:100750740"/>
    <dbReference type="CTD" id="9290"/>
    <dbReference type="eggNOG" id="ENOG502QWNM">
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    <dbReference type="OrthoDB" id="9447539at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="G protein-coupled receptor 55"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF56">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="157"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="209"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="37"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGW08952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035294743.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38044" checksum="B8AAD90080790DD3" modified="2011-11-16" version="1">MSRPYASDNCSFDDVDKLMSTLQLAVHIPTFLLGLVLNLLAIRGFSTFLKKKQLEYIATSIYMINLAVFDLLLVLSLPFKMALPQVESPPQVFCTLVECLYFISMYGSIFTICFISVDRFLAIQYPLLVNHLRSPRKAFGICCSLWILVWVGSIPIYTFHREVEKYKCFHNMSDGTWSAKVFFPLEIFGFLLPMGIMGFCSYRIIHILLRCRNPVQQRACIWTIATNLVIFVVSFLPVHLGFFLQFLVRNGFIVECRAKQNISLFLQLSLCFSNINCCLDVFCYYFVIKEFRMGIKGPQASTVELVRQDTMISRGYGEVPLSKEGDPSPEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3IIW0</accession>
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    <protein>
        <submittedName>
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        <submittedName>
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    <gene>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
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    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the requiem/DPF family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSCGRP00001021196.1"/>
        <property type="gene ID" value="ENSCGRG00001020101.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
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    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="209"/>
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        </location>
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        <location>
            <begin position="270"/>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Cricetulus</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CHO K1 cell line</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5 6">17A/GY</strain>
            <tissue evidence="5 6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH004664">
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        <property type="nucleotide sequence ID" value="XM_027432046.2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="TF_A-like/BEX"/>
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    <dbReference type="Pfam" id="PF04538">
        <property type="entry name" value="BEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
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        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
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        <location>
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            <end position="73"/>
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        <location>
            <begin position="164"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW14651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027287847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027287852.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21962" checksum="6DF4112E2BB70F70" modified="2011-11-16" version="1">MEELSREKEAVPSKQAQVENGKEPQEEGQSEVAFSPEEEERSESQAKAGDEGMLPRRQEQPEPERRAKQEGRPETQGNPEFSKGNPAGKRPAEDPLPRKAKRKTNKGLAHCLKEYKEAIHDMHFSNEDMIREFDNMARVKEDERKNKQKMGHIFWMQRSLQDPFHPRGPREFRGGCRAPRRDIEDIPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-11-13" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U3GSH1</accession>
    <name>U3GSH1_CRIGR</name>
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        <submittedName>
            <fullName evidence="3 6">Neurosecretory protein VGF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">VGF nerve growth factor inducible</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">Vgf</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="27434" last="27443">
            <title>Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.</title>
            <authorList>
                <person name="Hannedouche S."/>
                <person name="Beck V."/>
                <person name="Leighton-Davies J."/>
                <person name="Beibel M."/>
                <person name="Roma G."/>
                <person name="Oakeley E.J."/>
                <person name="Lannoy V."/>
                <person name="Bernard J."/>
                <person name="Hamon J."/>
                <person name="Barbieri S."/>
                <person name="Preuss I."/>
                <person name="Lasbennes M.C."/>
                <person name="Sailer A.W."/>
                <person name="Suply T."/>
                <person name="Seuwen K."/>
                <person name="Parker C.N."/>
                <person name="Bassilana F."/>
            </authorList>
            <dbReference type="PubMed" id="23940034"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.497214"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="KF309065">
        <property type="protein sequence ID" value="AGT98522.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001315039.1">
        <property type="nucleotide sequence ID" value="NM_001328110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U3GSH1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005774.1">
        <property type="protein sequence ID" value="ENSCGRP00001003919.1"/>
        <property type="gene ID" value="ENSCGRG00001004872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769566"/>
    <dbReference type="KEGG" id="cge:100769566"/>
    <dbReference type="CTD" id="7425"/>
    <dbReference type="GeneTree" id="ENSGT00390000017745"/>
    <dbReference type="OrthoDB" id="8926660at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051591">
        <property type="term" value="P:response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002021">
        <property type="term" value="P:response to dietary excess"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026128">
        <property type="entry name" value="VGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15159">
        <property type="entry name" value="NEUROSECRETORY PROTEIN VGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15159:SF2">
        <property type="entry name" value="NEUROSECRETORY PROTEIN VGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038206396" evidence="2 6">
        <location>
            <begin position="24"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AGT98522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="NP_001315039.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="68218" checksum="CCFFD26C374F3890" modified="2013-11-13" version="1">MKTLRLPASVLFCFLLLIQGLGAAPPGRADAYPPPLGSEHKEQIAEDAVSRPKDDSVPEVRAARNSEPQDQGELFQGVDPRALAAVLLQALDRPASPPAVPGGPQQGTPEEAAEALLTESVRSQTHSLSAPEIQAPAAAPPRPQTQDNDPEADDRSEELEALASLLQELRDFSPSNAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPVPSQFQARMPESAPLPETHQFGEGVASPKTHLGETLTPLSKAYQSLGGPFPKVRRLEGSLLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRDLGGRGLQETQQERESEREEEAEQERRGGGEDEMGDEDEEAAEAEAEAEEAERARQNALLFAEEEEDGEAGAEDKRSQEEAPGHRRKDAEGAEEGGEEDDDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPARDELPDWNEVLPPWDREEEEVFPPGPYHPFPNYIRPRTLQPPASSRRRHFHHALPPARHHPDLEAQARRAQEEADAEERRMQEQEELENYIEHVLLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HZS8</accession>
    <name>A0A061HZS8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine-protein phosphatase non-receptor type</fullName>
            <ecNumber evidence="8">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18 19" type="primary">Ptpn14</name>
        <name evidence="14" type="ORF">H671_5g15049</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19">17A/GY</strain>
            <tissue evidence="18 19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="8"/>
    <dbReference type="EMBL" id="KE680475">
        <property type="protein sequence ID" value="ERE72390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274514.1">
        <property type="nucleotide sequence ID" value="XM_027418713.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301452.1">
        <property type="nucleotide sequence ID" value="XM_035445561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HZS8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022249.1">
        <property type="protein sequence ID" value="ENSCGRP00001018005.1"/>
        <property type="gene ID" value="ENSCGRG00001017884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761406"/>
    <dbReference type="KEGG" id="cge:100761406"/>
    <dbReference type="CTD" id="5784"/>
    <dbReference type="GeneTree" id="ENSGT00940000156874"/>
    <dbReference type="OrthoDB" id="10012364at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001946">
        <property type="term" value="P:lymphangiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046825">
        <property type="term" value="P:regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13188">
        <property type="entry name" value="FERM_C_PTPN14_PTPN21"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd17191">
        <property type="entry name" value="FERM_F1_PTPN14"/>
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    <dbReference type="CDD" id="cd14599">
        <property type="entry name" value="PTPc-N14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000014">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000149">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000039">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000030">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014392">
        <property type="entry name" value="PTP_non-rcpt_14/21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041782">
        <property type="entry name" value="PTPN14/21_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF6">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000934">
        <property type="entry name" value="Tyr-Ptase_nr14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="13">
        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="907"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="9">
        <location>
            <position position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000934-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE72390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027274514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035301452.1"/>
        </source>
    </evidence>
    <sequence length="1185" mass="134542" checksum="DF62EC65A10174CA" modified="2014-09-03" version="1">MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKLANEPLLFFGVMFYVPNVSWLHQEATRYQYYLQVKKDVLEGRLRCTLEQVIRLAGLAVQADFGDYNQFDSQEFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQETFPVKDNQGNSMHLGIFFMGIFVRNRIGRQAVIYRWNDIGSVTHSKSSILLELIDKEETALFHTDDIENAKYISRLFTTRHKFYKQNKICTEPSNSPPPIRRQPTWSRSSLPRQQPYILPPMHVQSSEHYSETHTSQDSIFPGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSINSLSCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSTIIVPSYRPTPDYETVMRQMKRGLLHADSQSRSLRNLNIINTHAYTQPEELVYSQPEMRDRHPYTVPYAPQGGYGHKLVSPSDQMNPKNSTVPSQPGASSISHTVSTPELANMQLQGTQNYSTAHMLRNCLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLNIPMARRNTLREQGPSEEAGGHEVHGLPQYHHKKTLSDATMLIHSSDSEEEEEAPEAVPQIPVLREKVEYSAQLQAALARIPNRPPPEYPGPRKSVSNGALRQDQGTLLPAVARARVLRHGPSKALSVSRAEQLAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMTRNLEKQKMAGLDPQRRPLMLAALNGLSVARVPGREDSRQDATRVPIDDRLRALKKKLEEGMVFTEYEQIPNKKANGVFSTATLPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSGCYATTGLKVKHLLSGQERTVWHLQYTDWPHHGCPEDVQGFLSYLEEIQSVRRHTNSVLEGIKTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHNEKVEVPTMLRFLREQRMFMIQTIAQYKFVYQVLVQFLQNSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I7Y7</accession>
    <name>A0A061I7Y7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA-binding protein 24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding motif protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Rbm24</name>
        <name evidence="15" type="ORF">H671_3g9885</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
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    <reference evidence="18" key="4">
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                <person name="Dhiman H."/>
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                <person name="Betenbaugh M.J."/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ERE79974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035298752.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45804" checksum="42AF576547DB16CD" modified="2014-09-03" version="1">MSPVSRSRPNEDSLGSQKRRRDSDSPLSVLQTRRSPRGGGFGLHLSAFEGLRPPRGTEGPRLAHWVSRPRSGERPPPPGIRTFASSSPPSICGGYRCHHYAGDRLWAEDQEKEKEESYRLRRLKERERIGELGAPEVWGLSPKFPEPDSDEHTPAEDEVKNQKSSSSDFTNEDKRSKTSHSTKRKRKKKLSKRKHRKYCDNDSDSDSDIHSSSGGDRKKFKTKKKEKKKKHRAKQLKKKRRTKKDYGDINYKALERELPEDAWMEQSMSADAMDLIGPEAPVIHTSQDEKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IGM8</accession>
    <name>A0A061IGM8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coenzyme Q-binding protein COQ10 homolog B, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Coq10b</name>
        <name evidence="11" type="ORF">H671_2g6482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE668506">
        <property type="protein sequence ID" value="ERE83761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016832098.2">
        <property type="nucleotide sequence ID" value="XM_016976609.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252701.1">
        <property type="nucleotide sequence ID" value="XM_027396900.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IGM8"/>
    <dbReference type="GeneID" id="100773426"/>
    <dbReference type="KEGG" id="cge:100773426"/>
    <dbReference type="CTD" id="80219"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000002">
        <property type="entry name" value="Coenzyme Q-binding protein COQ10 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF9">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10 HOMOLOG B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="10">
        <location>
            <begin position="86"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ERE83761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027252701.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27493" checksum="487816A7D7A8C5E2" modified="2014-09-03" version="1">MAARTSQRALARVVSGCRPKSTTVAEAPTRGPARNVRYLASCGILMNRTLPPHTSVLPKEIYARTFFKITAPLVNKRKEYSERRIIGYSMQEMYDVVSGMEDYKHFVPWCKKSDIISRRSGYCKTRLEVGFPPVLERYTSVVTLVKPHLVKASCTDGKLFNHLETIWRFSPGLPGYPRTCTLDFSVSFEFRSLLHSQLATLFFDEVVKQMVAAFERRACKLYGPETNIPRELMLHEIHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IL27</accession>
    <name>A0A061IL27_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Periostin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Osteoblast-specific factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Postn</name>
        <name evidence="21" type="ORF">H671_1g2173</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. Interacts with BMP1 and fibronectin.</text>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Laux H."/>
                <person name="Kollin F."/>
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                <person name="Grillari J."/>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
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                <person name="Jadhav V."/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035742">
        <property type="entry name" value="SPRY/PRY_FSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF8">
        <property type="entry name" value="FSD1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COS" evidence="6">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="268"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
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        <source>
            <dbReference type="PROSITE" id="PS51262"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ERE84570.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012713.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027258878.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="55899" checksum="06032FB46DC13289" modified="2014-09-03" version="1">MDSQKEALQRIISTLANKNDEIQNFIDTLNHTLKGLQENSSNILSELEEEFDSLYSMLDDVKESMVSSIKQEQVRKSQELQSQLSQCNNALENSEELLEFATRSLDIKEPEEFSKAARQIKDRVTMASAFRLSLKPKVSENMTHLMVDFSQERQMLQTLKFLPVPKAPEIDPVECLVADNSVTVAWRMPEEDNKIDHFVMEYRKTNFDGLPRVKDERCWEMIDNIKGSEYTLSGLKFDSKYMNFRVRACNKAVAGEYSDPVTLETKALNFSLDNSSSHLNLKVEDSCVEWDPTGGKGQESKIKGKENKGRSGTPSPKRTSVGSRPPAVRGSRDRFTGESYTVLGDTAIENGQHYWEVKAQKDCKSYSVGVAYKTLGKFDQLGKTNTSWCIHVNSWLQNTFAAKHNNKVKVLDVPVPEKIGVFCDFDGGQLSFYDAHSKQLLYSFKTKFTQPVLPGFMIWCGGLSLSTGMQVPSAVKTLQRSENGMTGSGSSLNNVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IPX1</accession>
    <name>A0A061IPX1_CRIGR</name>
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        <submittedName>
            <fullName evidence="7 8 11">Neuromedin-U</fullName>
        </submittedName>
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    <gene>
        <name evidence="8 11" type="primary">Nmu</name>
        <name evidence="7" type="ORF">H671_1g1455</name>
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    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NmU family.</text>
    </comment>
    <dbReference type="EMBL" id="KE663849">
        <property type="protein sequence ID" value="ERE90741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308372.1">
        <property type="nucleotide sequence ID" value="XM_035452481.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317820.1">
        <property type="nucleotide sequence ID" value="XM_035461929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IPX1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014466.1">
        <property type="protein sequence ID" value="ENSCGRP00001010245.1"/>
        <property type="gene ID" value="ENSCGRG00001012189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771232"/>
    <dbReference type="KEGG" id="cge:100771232"/>
    <dbReference type="CTD" id="10874"/>
    <dbReference type="OMA" id="LWSEQEL"/>
    <dbReference type="OrthoDB" id="9879773at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031839">
        <property type="term" value="F:type 1 neuromedin U receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031840">
        <property type="term" value="F:type 2 neuromedin U receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045987">
        <property type="term" value="P:positive regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060259">
        <property type="term" value="P:regulation of feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000821">
        <property type="term" value="P:regulation of grooming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001659">
        <property type="term" value="P:temperature homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018070">
        <property type="entry name" value="Neuromedin-U_amidation-site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042384">
        <property type="entry name" value="NMU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008200">
        <property type="entry name" value="NMU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15390">
        <property type="entry name" value="NEUROMEDIN-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15390:SF0">
        <property type="entry name" value="NEUROMEDIN-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02070">
        <property type="entry name" value="NMU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00084">
        <property type="entry name" value="NMU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00967">
        <property type="entry name" value="NMU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044538613" evidence="5">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Neuromedin U C-terminal" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ERE90741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035308372.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19183" checksum="333F8C1DCCF8948C" modified="2014-09-03" version="1">MSRAAGSRPGLSGGQVAAASPLLSLLLLLACFADACRGAPVSPQRIRSEQELQLWNKVHDACSSFLSSDSQPQGSTALREFCRLVTESLQKPLEQNEKHNTKRFLFHYSKTEKSGNSNIVSSVVHPLLQLVPQLHERRMKRFKEELQSPFAGQSRGYFLFRPRNGKRSAGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7GUL9</accession>
    <name>A0A3L7GUL9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 13">Arylsulfatase i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Arsi</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258612.1">
        <property type="nucleotide sequence ID" value="XM_027402811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7GUL9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001004915.1">
        <property type="protein sequence ID" value="ENSCGRP00001003415.1"/>
        <property type="gene ID" value="ENSCGRG00001004125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765546"/>
    <dbReference type="KEGG" id="cge:100765546"/>
    <dbReference type="CTD" id="340075"/>
    <dbReference type="GeneTree" id="ENSGT00940000157656"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000002">
        <property type="entry name" value="Arylsulfatase family member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000007">
        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF68">
        <property type="entry name" value="ARYLSULFATASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594344" evidence="8">
        <location>
            <begin position="24"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="9">
        <location>
            <begin position="47"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027258612.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="63920" checksum="179C1A2EEFE44C53" modified="2019-02-13" version="1">MHALSGFSLVSLLSLGYLSWDWAKPGLVADGPAEASDQSSAAPSQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGETVAWGLSGQYSTMLYAQRASHILASHSPQNPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKKKRRTSRALVHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLASFPGSWWNLERMASIRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLADYNRTAIPVRYPAANPRAHPDFNGGAWGPWATDEEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HP06</accession>
    <name>A0A3L7HP06_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Zinc finger MYND domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Zmynd10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 15">Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts (via C-terminus) with DNAAF11 (via CS domain); this interaction stabilizes DNAAF11 at the protein level. Interacts (via C-terminus) with DNAL1; this interaction stabilizes DNAL1 at the protein level. Interacts with DNAAF4, HSPA8, IQUB, RUVBL2 and DYNTL5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ZMYND10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003500447.1">
        <property type="nucleotide sequence ID" value="XM_003500399.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270262.1">
        <property type="nucleotide sequence ID" value="XM_027414461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HP06"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016645.1">
        <property type="protein sequence ID" value="ENSCGRP00001012411.1"/>
        <property type="gene ID" value="ENSCGRG00001013828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752121"/>
    <dbReference type="KEGG" id="cge:100752121"/>
    <dbReference type="CTD" id="51364"/>
    <dbReference type="GeneTree" id="ENSGT00940000153820"/>
    <dbReference type="OMA" id="LIHEAYC"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905505">
        <property type="term" value="P:positive regulation of motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000009">
        <property type="entry name" value="Zinc finger MYND domain-containing protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017333">
        <property type="entry name" value="UCP037948_Znf-MYND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037948">
        <property type="entry name" value="UCP037948_Znf_MYND10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="17">
        <location>
            <begin position="394"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027270262.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50558" checksum="09BFC493B19317FC" modified="2019-02-13" version="1">MGDLELLLPGEAEVLVRGLCSFPLPEMGSEGWSKQHESLEKLNMQAILDATVSQGEPIQELLVTHGKIPTLVEELIAVEMWKQKVFPVLCRLEDFKPHNTFPIYMVVHHEASIINLLETVFFHKEVCESADDKVLDLVDYCHRKLILLVARTGCGDPYEEERSQDSTPMQELQKQAEMMEFEISLKALSVLRYITDCVDSLSPSTLNRMLRTHNLPCLLVELLEHSPWCRREGGKLQQFENGRWQTVPPSEQQRLNKLDGQVWITLYNLLLSPEAQARYCLTSFVKGQLLKLQAFLTDTLLDQLPNLADLKGFLAHLALAETQPPKKDLVLEQIPEIWNQLERENKGKWQAIAKHQLQHVFSPSEKDLRRQAQRWAETYRLDVLEAIAPERPHCAYCQAEASKRCSRCQSVWYCCRDCQVKHWEKHGKTCVLAAQGDRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HQ14</accession>
    <name>A0A3L7HQ14_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="10 11">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Eukaryotic translation initiation factor 3 subunit 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">eIF-3-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Eif3b</name>
        <name evidence="10" type="synonym">EIF3B</name>
        <name evidence="10" type="synonym">EIF3S9</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 10">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2 and HNRPD. Interacts with METTL3. Interacts with DDX3X.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2. Interacts with METTL3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The RRM domain mediates interaction with EIF3J.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Phosphorylated. Phosphorylation is enhanced upon serum stimulation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269310.1">
        <property type="nucleotide sequence ID" value="XM_027413509.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HQ14"/>
    <dbReference type="SMR" id="A0A3L7HQ14"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024251.1">
        <property type="protein sequence ID" value="ENSCGRP00001020007.1"/>
        <property type="gene ID" value="ENSCGRG00001019278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762979"/>
    <dbReference type="KEGG" id="cge:100762979"/>
    <dbReference type="CTD" id="8662"/>
    <dbReference type="GeneTree" id="ENSGT00550000074913"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075522">
        <property type="term" value="P:IRES-dependent viral translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075525">
        <property type="term" value="P:viral translational termination-reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000489">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001855">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000164">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="172"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027269310.1"/>
        </source>
    </evidence>
    <sequence length="801" mass="91377" checksum="C8195D97B3B54632" modified="2019-02-13" version="1">MQDAENVAAPEAAEERAEPARQQPASESPPADETVGSGGSEVGQTEDAEEEAGPEPEVRAKRAAQPEEETATSPAVSPPPQPAERSSAQEPSAPGKAEASGEQAREHSVAGAEEEGGSDGSSPEAEPRALENGEADEPSFSDPEDFVDDVSEEELLGDILKDRPQEADGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKIINDYYPEEDGKTKGYIFLEYASPAHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESGDRTSIFRNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWDPTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQDQIKQIKKDLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRQYRKMAQELYMKQKNERLELRGGVDTDELDSNVDDWEEETIEFFVTEEIIPLGSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HTS8</accession>
    <name>A0A3L7HTS8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead box F1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Forkhead box protein F1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Foxf1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027266516.1">
        <property type="nucleotide sequence ID" value="XM_027410715.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HTS8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015272.1">
        <property type="protein sequence ID" value="ENSCGRP00001011043.1"/>
        <property type="gene ID" value="ENSCGRG00001012787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757169"/>
    <dbReference type="KEGG" id="cge:100757169"/>
    <dbReference type="CTD" id="2294"/>
    <dbReference type="GeneTree" id="ENSGT00940000161035"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003214">
        <property type="term" value="P:cardiac left ventricle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071345">
        <property type="term" value="P:cellular response to cytokine stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014822">
        <property type="term" value="P:detection of wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097070">
        <property type="term" value="P:ductus arteriosus closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048613">
        <property type="term" value="P:embryonic ectodermal digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048617">
        <property type="term" value="P:embryonic foregut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003197">
        <property type="term" value="P:endocardial cushion development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061030">
        <property type="term" value="P:epithelial cell differentiation involved in mammary gland alveolus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060441">
        <property type="term" value="P:epithelial tube branching involved in lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045198">
        <property type="term" value="P:establishment of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048371">
        <property type="term" value="P:lateral mesodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048286">
        <property type="term" value="P:lung alveolus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060463">
        <property type="term" value="P:lung lobe morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060426">
        <property type="term" value="P:lung vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090131">
        <property type="term" value="P:mesenchyme migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007494">
        <property type="term" value="P:midgut development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043305">
        <property type="term" value="P:negative regulation of mast cell degranulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031016">
        <property type="term" value="P:pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002053">
        <property type="term" value="P:positive regulation of mesenchymal cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060461">
        <property type="term" value="P:right lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051145">
        <property type="term" value="P:smooth muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060438">
        <property type="term" value="P:trachea development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072189">
        <property type="term" value="P:ureter development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060841">
        <property type="term" value="P:venous blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20049">
        <property type="entry name" value="FH_FOXF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000071">
        <property type="entry name" value="Forkhead box F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051770">
        <property type="entry name" value="Forkhead_box_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46262">
        <property type="entry name" value="FORKHEAD BOX PROTEIN BINIOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46262:SF1">
        <property type="entry name" value="FORKHEAD BOX PROTEIN F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027266516.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="39962" checksum="18EA5DB89B636476" modified="2019-02-13" version="1">MSAPDKQQPPHGGGTGGGGGAGSQAMDPAAAGPTKAKKTNAGVRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPVYSMVNGLGFNHLPDTYGFQGSGGLSCAPNSLALEGGLGMMNGHLAGNVDGMALPSHSVPHLPSNGGHSYMGGCGGSGAGEYPHHDSSVPASPLLPAGAGGVMEPHAVYSSSAAAWPPSASAALNSGASYIKQQPLSPCNPAANPLSGSLSTHSLDQPYLHQNSHNGPAELQGIPRYHSQSPSMCDRKEFVFSFNAMASSSMHSTGGGSYYHQQVTYQDIKPCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I372</accession>
    <name>A0A3L7I372_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Grhpr</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258993.1">
        <property type="nucleotide sequence ID" value="XM_027403192.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I372"/>
    <dbReference type="SMR" id="A0A3L7I372"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015868.1">
        <property type="protein sequence ID" value="ENSCGRP00001011636.1"/>
        <property type="gene ID" value="ENSCGRG00001013235.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752744"/>
    <dbReference type="KEGG" id="cge:100752744"/>
    <dbReference type="CTD" id="9380"/>
    <dbReference type="GeneTree" id="ENSGT00940000158578"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF137">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="9"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027258993.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35460" checksum="F3DDE587746D7669" modified="2019-02-13" version="1">MKPARLMKVFVTGPFPPEGMAALAKAADCEVEQWNSDDPIPRKKLEESVAGAHGLLCRLTDRVDQKLLDAAGANLRVISTLSVGVDHLALDEIKKRGIRVGYTPGVLTDATAELAVSLLLTTCRRLPEAIEEVKNGGWDSWKPLWMCGYGLSQSTVGIVGLGRIGQAIARRLKPFGVQRFLYTGRQPRPQEAAEFQAEFVPIAQLAAESDFIVVSCSLTPATRGLCSKEFFQNMKNTAVFINISRGDVVNQDDLYQALTSGQLAAAGLDVTTPEPLPPSHPLLTLKNCVILPHIGSATYKTRNTMALLAANNLLAGLRGETMPSELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I7K9</accession>
    <name>A0A3L7I7K9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Slc9a3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis. Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) + H(+)(out) = Na(+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255967.1">
        <property type="nucleotide sequence ID" value="XM_027400166.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I7K9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029005.1">
        <property type="protein sequence ID" value="ENSCGRP00001024759.1"/>
        <property type="gene ID" value="ENSCGRG00001022559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755928"/>
    <dbReference type="KEGG" id="cge:100755928"/>
    <dbReference type="CTD" id="6550"/>
    <dbReference type="GeneTree" id="ENSGT00940000158616"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018410">
        <property type="entry name" value="Na/H_exchanger_3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF90">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01087">
        <property type="entry name" value="NAHEXCHNGR3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0915">Sodium</keyword>
    <keyword evidence="15 18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594452" description="Sodium/hydrogen exchanger" evidence="20">
        <location>
            <begin position="29"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="21">
        <location>
            <begin position="59"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027255967.1"/>
        </source>
    </evidence>
    <sequence length="831" mass="93348" checksum="CD2C61FC673C6340" modified="2019-02-13" version="1">MWHRALGPGWKPLLALALALTSLQGARAFEEEPSPDGSFQVVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDKVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPLIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYLLRENVSTVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNFVIKEKDLELSEPEEVTNYEETSGGIEFLANVTKDVTSESGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLLADGPEEQLQPASPESTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2L7R1</accession>
    <name>A0A8C2L7R1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Mitogen-activated protein kinase kinase kinase 14</fullName>
            <ecNumber evidence="3 15">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 22 23 24" type="primary">Map3k14</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23 24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23 24">17A/GY</strain>
            <tissue evidence="22 23 24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3 15"/>
    <dbReference type="RefSeq" id="XP_003504581.3">
        <property type="nucleotide sequence ID" value="XM_003504533.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283832.1">
        <property type="nucleotide sequence ID" value="XM_027428031.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035304237.1">
        <property type="nucleotide sequence ID" value="XM_035448346.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035304238.1">
        <property type="nucleotide sequence ID" value="XM_035448347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2L7R1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000747.1">
        <property type="protein sequence ID" value="ENSCGRP00001000723.1"/>
        <property type="gene ID" value="ENSCGRG00001000574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766459"/>
    <dbReference type="KEGG" id="cge:100766459"/>
    <dbReference type="CTD" id="9020"/>
    <dbReference type="GeneTree" id="ENSGT00940000156497"/>
    <dbReference type="OrthoDB" id="5836549at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13991">
        <property type="entry name" value="STKc_NIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000383">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000326">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042787">
        <property type="entry name" value="M3K14_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017425">
        <property type="entry name" value="MAPKKK14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF9">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038175">
        <property type="entry name" value="MAPKKK14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="401"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="664"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="796"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR038175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027283832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035304237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035304238.1"/>
        </source>
    </evidence>
    <sequence length="938" mass="102976" checksum="3A49AE4837DDF26F" modified="2022-01-19" version="1">MAVMEVACPGTPGSAVGQQKELAKAKEKTQSLGKKQSCIYKLEAVEKSPVFCGKWEILNDVITKGTAKDGSEGGPPAISIIAQAECENSQEFSPTFSERIFIAGSQQYSQSESLDQIPNNVAHATEGKMARVCRKGKRHSKARKKRKKRRSKSQAQAGVALAKPLPRTPEQESCTVPVQEDESPLGTLYARNVSQFTKPLKEPDLGHLCCKKQGEGLRPVLPRPELHKLISPLQCLNHVWKLHHPQAVGPPPHSTHPFPYSRLPHPFPFHPLEPWRPYPLESIFLDKLAGVSGQQPLRGPHLSKLAYGNSQKPLPGPHLESSYPSRGAQEKAPVEEYLVHALQGSVSSGQANSLTSLAKTWTSGSSKPQRLSPETEDNEGVLLTEKLKPVDYEYREEVHWVTHQPRLGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQKGCLPEDRALYYLGQALEGLEYLHIRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDCIPGTETHMAPEVVMGKPCDTKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPVREIPPSCAPLTVQAIQEGLRKEPGHRASAMELRGKVGQALQQVGGLKSPWKGEYKEPRPPPPDQATCHQTPPRENPPAKASTDGASEPRPPLPPEPPEQSRAPAPNLSKEESGTWEPLPLSSLEPAPAKGPSFPDRRATFPELELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSVSEDSEKNPSKASQSSRDTLSSGVHSWSSQTEARSSSCNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTKDGQPVHYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LBW8</accession>
    <name>A0A8C2LBW8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">C-terminal PDZ ligand of neuronal nitric oxide synthase protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nitric oxide synthase 1 adaptor protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">LOC100771018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027272863.1">
        <property type="nucleotide sequence ID" value="XM_027417062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LBW8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003084.1">
        <property type="protein sequence ID" value="ENSCGRP00001002363.1"/>
        <property type="gene ID" value="ENSCGRG00001002529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771018"/>
    <dbReference type="KEGG" id="cge:100771018"/>
    <dbReference type="OrthoDB" id="10030336at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050998">
        <property type="term" value="F:nitric-oxide synthase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01270">
        <property type="entry name" value="PTB_CAPON-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000124">
        <property type="entry name" value="carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027851">
        <property type="entry name" value="DUF4628"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF76">
        <property type="entry name" value="CARBOXYL-TERMINAL PDZ LIGAND OF NEURONAL NITRIC OXIDE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15429">
        <property type="entry name" value="DUF4628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="9">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="626"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027272863.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="75642" checksum="5D808B9E98B562F2" modified="2022-01-19" version="1">MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLAGAERASTATAEETDIDAVEVPLPRNDVLDFSRGVTDLDAVGKEGSSHIDSTVSPHPQEPMLTASPRMLLPSSSSKPPGLGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISVLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCEPTTPKPEDLHSPLLGAGLADFAHPAGSPLVDHSMFENLNTALTPKLQSSRSFPHLSRSVAPSSITPGSAEPGGPGLRVGSSQHLKNLGKAMGAKVNDLLRRKESSSLGSVGVMEINKTAGAQLAGGEDAACGAWLEDDRSVQEAFPLLDPPPPITRKRTPRALKTTQDMLISSQPVLSSLEYGTELSPGQAQDSPPTAQPVSADNSRPESTIEMRDKGEALANGEESLLVPDLIHRNSQEESKLKATECRKASSPDPIARNGLKLSLSPISLAESWESISPPPRARTSSLDNEGLHPDLLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LEL1</accession>
    <name>A0A8C2LEL1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Enhancer of filamentation 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">CRK-associated substrate-related protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Neural precursor cell expressed developmentally down-regulated protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">p105</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33 36" type="primary">Nedd9</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
            <tissue evidence="36">Liver</tissue>
        </source>
    </reference>
    <reference evidence="33" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CAS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003506574.1">
        <property type="nucleotide sequence ID" value="XM_003506526.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266213.1">
        <property type="nucleotide sequence ID" value="XM_027410412.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LEL1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001325.1">
        <property type="protein sequence ID" value="ENSCGRP00001001286.1"/>
        <property type="gene ID" value="ENSCGRG00001000996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765156"/>
    <dbReference type="KEGG" id="cge:100765156"/>
    <dbReference type="CTD" id="4739"/>
    <dbReference type="GeneTree" id="ENSGT00950000183008"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
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    <sequence length="834" mass="92956" checksum="DB441C1BF40A15BE" modified="2022-01-19" version="1">MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPVQETSSHEQPTPGPMHQTFGQQKLYQVPNSQAASRDTIYQVPPSYQNQGIYQVPTGHGTPEPDVYQVPPSVQRNIGGTNGPHLGKKVITPVRTGHGYVYEYPTRYQKDVYDVPPSHTAQGVYDIPPSSVKGPVFSVPVGEIKPQGVYDIPPTQGVYAIPPSAYRDEAGLREKEYDFPSPMKQDGRPDTRPEGVYDIPPTSTKTAGKDLHSKFTCDAPGAAEPMARRHQNLSLHHPPSQLGQSGGTPSDAYDVPRGVQFLEAPTETSEKANLEERDGVYDVPLHNPADGKGSRDVVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPSQDKRLLLDPDTAIEKLYRLQQTLEMGVCSLTSLVTTDWRCYGYMERHINEIRTAVDKVELFLREYLHFARGALANASCLPELVLHTKMKRELQRVEDSHQILSQTSHDLNECSWSLNVLAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRAAGPGSSHLKNGPDSITNSSEYTHTGSQMQPLRPGDYKAQVHNKPLPPTLGKEQPPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIIKQSKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQTLPTTNNSVGAQDRQLLCFYYDQCETHFISLLNAIDALFNCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVRNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LR53</accession>
    <name>A0A8C2LR53_CRIGR</name>
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    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027268053.1">
        <property type="nucleotide sequence ID" value="XM_027412252.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSCGRP00001007101.1"/>
        <property type="gene ID" value="ENSCGRG00001009566.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027268053.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35037" checksum="64FA3EB4F924CEE3" modified="2022-01-19" version="1">MDSVNVSLVTEFILVGLTDRPELQMPLFFVFLTMYVVTALGNLCLIILTVVNSNLHTPMYFFLFNLSFVDLFYCSVFTLQMLMNFILRKKVISYMECMTQVFFFSFFVVSECYVLTSMAYDCYMAICNPLLYNVVMSPKLCLNLMLGCYFIAFSNAVAHTVCMLRLTFCDGNTINHYFCDIPPLLQLSCTSTYVNKLVIFVLGGISIIVPTSTIFVSYGFILSSIFHISSSEGRSKAFSTCSSHVFAVFLFFGSGAFVYFKPSSAGSMNEAKISSVTYTNVVPMLNPLVYSLRNKDIKFALRKTLSSWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LV27</accession>
    <name>A0A8C2LV27_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100756288</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262395.1">
        <property type="nucleotide sequence ID" value="XM_027406594.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035292761.1">
        <property type="nucleotide sequence ID" value="XM_035436870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LV27"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013176.1">
        <property type="protein sequence ID" value="ENSCGRP00001009009.1"/>
        <property type="gene ID" value="ENSCGRG00001011177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756288"/>
    <dbReference type="KEGG" id="cge:100756288"/>
    <dbReference type="OrthoDB" id="9442037at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15407">
        <property type="entry name" value="7tmA_OR5B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027262395.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33982" checksum="8FE842743B0D2738" modified="2022-01-19" version="1">MKNMTEVTQFFLIGLTNTPGLQLPLFITFFFIYIITLLGNLGMFLLILLDSRLHTPMYIFLGNLSLVDLGYSSAITPKVMAGLLVGDKIMSYNDCAAQMFFFAGFATVENYLLASMAYDRYAAVCKPLHYTTTMTTGICAWLITGCYACGFLSACIYTGNTLSLSFCNSYVVHHFFCDMPAVMALSCSDSHINELVLICLASFTIFFALTIILLSYSIIIITILKMHSGTGYQKAISTCISHFTAVSIFYGTIIFMYLQPSSRHAMDTDKIVSVFYTMVIPMLNPLVYSLRNKEVKRAFMKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LVG1</accession>
    <name>A0A8C2LVG1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Myosin-7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Myosin heavy chain 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Myosin heavy chain slow isoform</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Myosin heavy chain, cardiac muscle beta isoform</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">LOC100772734</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECPAS. Interacts (via C-terminus) with LRRC39.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035308421.1">
        <property type="nucleotide sequence ID" value="XM_035452530.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001013983.1">
        <property type="protein sequence ID" value="ENSCGRP00001009764.1"/>
        <property type="gene ID" value="ENSCGRG00001011739.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:stress fiber"/>
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        <property type="term" value="C:Z disc"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:microfilament motor activity"/>
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        <property type="term" value="P:adult heart development"/>
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        <property type="term" value="P:ATP metabolic process"/>
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        <property type="term" value="P:cardiac muscle contraction"/>
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    <dbReference type="GO" id="GO:0014898">
        <property type="term" value="P:cardiac muscle hypertrophy in response to stress"/>
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        <property type="term" value="P:skeletal muscle contraction"/>
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    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin heavy chain"/>
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    <dbReference type="FunFam" id="1.20.5.340:FF:000006">
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    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000003">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000007">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.850.10:FF:000115">
        <property type="entry name" value="Myosin heavy polypeptide 6"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
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        <property type="entry name" value="Kinesin_motor_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
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        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF1">
        <property type="entry name" value="MYOSIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="11 21" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="24">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="23">
        <location>
            <begin position="85"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="21">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1915"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1923"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_035308421.1"/>
        </source>
    </evidence>
    <sequence length="1935" mass="222875" checksum="121F7ED2F2D182A7" modified="2022-01-19" version="1">MADAEMAAFGAAAPFLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKAKIVSREGGKVTAETENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAFDVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPVDKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRKQLEAEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKGLNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LVT7</accession>
    <name>A0A8C2LVT7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">renin</fullName>
            <ecNumber evidence="4">3.4.23.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Angiotensinogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Ren</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.</text>
            <dbReference type="EC" id="3.4.23.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.15" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003505793.1">
        <property type="nucleotide sequence ID" value="XM_003505745.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273914.1">
        <property type="nucleotide sequence ID" value="XM_027418113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LVT7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011232.1">
        <property type="protein sequence ID" value="ENSCGRP00001007215.1"/>
        <property type="gene ID" value="ENSCGRG00001009655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763117"/>
    <dbReference type="KEGG" id="cge:100763117"/>
    <dbReference type="CTD" id="5972"/>
    <dbReference type="GeneTree" id="ENSGT00940000157898"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:signaling receptor binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:angiotensin maturation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:drinking behavior"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:hormone-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001823">
        <property type="term" value="P:mesonephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002018">
        <property type="term" value="P:renin-angiotensin regulation of aldosterone production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05487">
        <property type="entry name" value="renin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000032">
        <property type="entry name" value="renin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000037">
        <property type="entry name" value="Renin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034135">
        <property type="entry name" value="Renin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF24">
        <property type="entry name" value="RENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678653" description="renin" evidence="16">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="85"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027273914.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="44110" checksum="9EE8DD20A864892F" modified="2022-01-19" version="1">MDGRRMPLWGLLLILWSSCAFSLPTDTAAFGRILLKKMPSVREILKERGVDMTKLSAEWGKFTKRFSFGNGTSPVILTNYLDTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSPLYSACEIHSLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDIVTVGGIIVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQRVLKEEVFSVYYSRDSHLLGGEVVLGGSDPQHYQGNFHYVSVSRTGSWEIAMKGVSVGSATLLCEEGCVVVVDTGASYISGPTSSLKLIMQTLGAKERSTDDYVVDCSQVPSLPDISFHLGGRAYTLTSADYVLQNPYRNDDQCTLALHGLDIPPPTGPVWVLGASFIRKFYTEFDRHNNRIGFALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M4E5</accession>
    <name>A0A8C2M4E5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein transport protein Sec61 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC103159941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63. The SEC61 channel associates with the multi-pass translocon (MPT) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304317.1">
        <property type="nucleotide sequence ID" value="XM_035448426.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317243.1">
        <property type="nucleotide sequence ID" value="XM_035461352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M4E5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017411.1">
        <property type="protein sequence ID" value="ENSCGRP00001013174.1"/>
        <property type="gene ID" value="ENSCGRG00001014385.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:103159941"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.820:FF:000001">
        <property type="entry name" value="Transport protein Sec61 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035304317.1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7719" checksum="E1284934A41EA8B9" modified="2022-01-19" version="1">MDQVMPFVELSWQFVKDSIWLLKRCTKPDRKGFQKIAMATAIGFTVMGFTGFFVKLIHIPVDNIIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M6C2</accession>
    <name>A0A8C2M6C2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane and coiled-coil domain-containing protein 5A isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Transmembrane and coiled-coil domains 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Tmco5a</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003510201.1">
        <property type="nucleotide sequence ID" value="XM_003510153.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027420990.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M6C2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017407.1">
        <property type="protein sequence ID" value="ENSCGRP00001013170.1"/>
        <property type="gene ID" value="ENSCGRG00001014377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763134"/>
    <dbReference type="KEGG" id="cge:100763134"/>
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    <dbReference type="OMA" id="CTTMERE"/>
    <dbReference type="OrthoDB" id="9836264at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026617">
        <property type="entry name" value="SMCO2/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22422:SF7">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22422">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14992">
        <property type="entry name" value="TMCO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="120"/>
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    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027276791.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35642" checksum="DA9C4857712940C4" modified="2022-01-19" version="1">MEGQKENQLDYESEKMEILRLAQSKKNIISLNMDLERDMQRIDEANQELLLKIQEKENEVQRLESEITQTGDPAEDEDWEKENCTVMERERALQELEEETARLERKNEALVHSISELQRKLTRKSQKIVKCEQGDVEIAPEESKVKLQQLETSCADQEKELGKIMEDYAFVSQLCEDQALCIKKYQEALKRIEEELETGFLEREVSKVLSMDSEREKSNSLKSKRESVTKKASRFSKRIFRSLLFTTLFFIKLLGYLIFHLSFINPDLLINALPKILSRDVLWRLRCFLFPSLTLETEDMLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M8A1</accession>
    <name>A0A8C2M8A1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cingulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Cgn</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cingulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304442.1">
        <property type="nucleotide sequence ID" value="XM_035448551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307570.1">
        <property type="nucleotide sequence ID" value="XM_035451679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M8A1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019050.1">
        <property type="protein sequence ID" value="ENSCGRP00001014812.1"/>
        <property type="gene ID" value="ENSCGRG00001015582.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754199"/>
    <dbReference type="CTD" id="57530"/>
    <dbReference type="GeneTree" id="ENSGT00940000154489"/>
    <dbReference type="OMA" id="HWREMFQ"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF4">
        <property type="entry name" value="CINGULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="Myosin tail" evidence="9">
        <location>
            <begin position="861"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="877"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="355"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035307570.1"/>
        </source>
    </evidence>
    <sequence length="1197" mass="136975" checksum="2F4C472F3BC7C1C5" modified="2022-01-19" version="1">MMADPRGPVDHGVQIRFITEPEGATEMGTLRRGGRRPPKDARASTYGVAVRVQGIAGQPFVVLNSGEKGSDSFGVQIKGGNNRGSPGTPSSDPEIPENPYSQFKGVPAASQGSTSDEELKDHWNGRLLRSQSQASLTGLASVSPTNRSTSLLELAPEKTPPVNTIDTAPLSSVDSLINKFDSQIGGQGRGRIGRRTRTLPHEQRKRSQSLDSRLSRDTHDRDREHQSPNHWTPGTKYDNQVNSSKQPSKSQSPLSSFSRSRQTQDWVLQSFEEPREKIPDPTTVQFKSTPDLLRDQREAAPPGSADHVKATIYGILREGSSESEAAVRRKVSLVLEQMQPVGMVSPASTKALAGQGELTRKVEELQKKLDEEVKKRQKLEPSRIGLERQLEEKAEECSRLQELLEKRKAEVQQSTKELQNMKLLLCQEEGLRHGLETQVKELQIKLKQGQSPEPAKDILMKDLLETRELLEGVLEGKQRVEEQLRLRERELTALKGALKEEVASHDQEVEHVRLQYQRDTEQLRRSMQDVTQDHAAMEAERQKMSSLVRELQKELEETSEETGHWQNMFQKNKEELRATKQELLQLRMEKEEMEEELGEKMEILQRDLEQARASARDVHQFEELKKELRRTQGELKELQEERQTQEVAGRQRDQELEKQLATLRAEADRGRDLEQQNLQLQKTLQKLRQDCDEASKAKRASEAEAKLQGHRRTTVETTLRETQEENDDFRRRILGLEQQLKEARGLAEGGEAVEARLRDKVHRLEVEKEQLEEALNAAREEEGSLAAANRALEIRLDEAQRGLARLGQEQQALNRALEEEGRQREALRRSKAELEEQKHLLNKTVDRLNKELEQIGDDSKLALQQLQAQMEDYKEKARREVADAQRQAKDWASEAEKNSGGLSRLQDELQKLRQALQTSQAERDTARLDKELLAQRLQGLEQEAENKKRTQDDKARQLKNLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASFSQLEAQNQQLQEQLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKTLKRQVDEAEEEIARLDSLRKKAQRELEEQHEINEQLQARIKALEKDAWRKASRSATEAAFKQEELSSDEEFDSVYDPSSIASLLTESNLQTSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MCI7</accession>
    <name>A0A8C2MCI7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">APOBEC1 complementation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">APOBEC1-stimulating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">A1cf</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2. Interacts with RBM47.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035298984.1">
        <property type="nucleotide sequence ID" value="XM_035443093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MCI7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021594.1">
        <property type="protein sequence ID" value="ENSCGRP00001017350.1"/>
        <property type="gene ID" value="ENSCGRG00001017413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767014"/>
    <dbReference type="KEGG" id="cge:100767014"/>
    <dbReference type="CTD" id="29974"/>
    <dbReference type="GeneTree" id="ENSGT00940000158678"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030895">
        <property type="term" value="C:apolipoprotein B mRNA editing enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140767">
        <property type="term" value="F:enzyme-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016554">
        <property type="term" value="P:cytidine to uridine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034383">
        <property type="term" value="P:low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010609">
        <property type="term" value="P:mRNA localization resulting in post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000623">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19900">
        <property type="entry name" value="DSRM_A1CF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12486">
        <property type="entry name" value="RRM1_ACF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12498">
        <property type="entry name" value="RRM3_ACF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000025">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000022">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000026">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000179">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044461">
        <property type="entry name" value="A1CF_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034538">
        <property type="entry name" value="ACF_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14709">
        <property type="entry name" value="DND1_DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="231"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035298984.1"/>
        </source>
    </evidence>
    <sequence length="595" mass="65513" checksum="B8CCCAAD8E8D6754" modified="2022-01-19" version="1">MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILLEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGARNTMMQGEYTYPLGHIYDPTTAYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRAPSVREIYMNVPVGAAGVRGLGSRGYLAYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVSLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFTPPKLSAYVDEAKTYAAEHTLQTLGIPTEGADTGTTAATATSATVFPGYAVPSATAPVSAAQLKQAVTLGQDLAAYTAYEVYPTFAVTTRGDAYGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQM3</accession>
    <name>A0A8C2MQM3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26 29 30 31 32" type="primary">Bmpr1a</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetidae</taxon>
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            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29 30 31" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29 30 31">17A/GY</strain>
            <tissue evidence="29 30 31">Liver</tissue>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
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        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_027389441.2"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:dorsal/ventral axis specification"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:embryonic digit morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:embryonic organ development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:endocardial cushion formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:epithelial cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:fibrous ring of heart morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:heart formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:hindlimb morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:immune response"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
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    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
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        <property type="term" value="P:MAPK cascade"/>
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        <property type="entry name" value="Snake_toxin-like_sf"/>
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    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF50">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0464">Manganese</keyword>
    <keyword evidence="17 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19 29 30" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678989" description="receptor protein serine/threonine kinase" evidence="23">
        <location>
            <begin position="24"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="25">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="234"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027245241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027245242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027245244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027245245.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="60063" checksum="8275B06A5FD804A2" modified="2022-01-19" version="1">MTQLYTYIRLLGACLFIICHVQGQNLDSMLHGTGMKSDLDQKKPENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVVLISMAVCIIAMIIFSSCFCYKHYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDIPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MR98</accession>
    <name>A0A8C2MR98_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase FANCL</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase FANCL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Fancl</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 26">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003499212.1">
        <property type="nucleotide sequence ID" value="XM_003499164.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243795.1">
        <property type="nucleotide sequence ID" value="XM_027387994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MR98"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026026.1">
        <property type="protein sequence ID" value="ENSCGRP00001021782.1"/>
        <property type="gene ID" value="ENSCGRG00001020523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759885"/>
    <dbReference type="KEGG" id="cge:100759885"/>
    <dbReference type="CTD" id="55120"/>
    <dbReference type="GeneTree" id="ENSGT00390000005537"/>
    <dbReference type="OMA" id="NRPFHAK"/>
    <dbReference type="OrthoDB" id="10263265at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23832">
        <property type="entry name" value="DRWD-C_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23831">
        <property type="entry name" value="DRWD-N_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23786">
        <property type="entry name" value="ELF_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16490">
        <property type="entry name" value="RING-CH-C4HC3_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000081">
        <property type="entry name" value="E3 ubiquitin-protein ligase FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.20:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000221">
        <property type="entry name" value="E3 ubiquitin-protein ligase FANCL isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.20">
        <property type="entry name" value="RWD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026848">
        <property type="entry name" value="Fancl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026850">
        <property type="entry name" value="FANCL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043898">
        <property type="entry name" value="FANCL_d2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044037">
        <property type="entry name" value="FANCL_d3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043003">
        <property type="entry name" value="FANCL_d3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019162">
        <property type="entry name" value="FancL_WD-rpt_cont_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN PHF9 FANCONI ANEMIA GROUP L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11793">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09765">
        <property type="entry name" value="FANCL_d1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18890">
        <property type="entry name" value="FANCL_d2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18891">
        <property type="entry name" value="FANCL_d3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fanconi anemia complex subunit FancL WD-repeat containing" evidence="18">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL UBC-like" evidence="20">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL UBC-like" evidence="21">
        <location>
            <begin position="200"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL C-terminal" evidence="19">
        <location>
            <begin position="303"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080616"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027243795.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42792" checksum="4CF56A55E091CF2C" modified="2022-01-19" version="1">MAEGDANLLRYFPLLLPRNREKTVYEGFISAQGSDFHLRIVLPKDLQLKKARLLCSWQLKNILNEYRQIVQQRMKQSPDLVSFMMELKMILEAALKRRRELCVQPPSRGFCTDLLNEIGAVGWDKLVCVDTSFSTIKLKAVDASGRKHVITVKLKAKYPVEPPDCVVDFPVPFSVSWTPQSSLVDVHSQFLAALESLKVFWDVMDEIDEKTWVLEPEKPPRSATARRIALGHNVSINIEVDPRHPTMLPEFCFLGADHVIKPLGVKLSENIHLWDPENSLLQNLKDVLEIDFPARTVLEESDFSMDCGICYARHLNGAIPDQVCDNPQCGQPFHQICLYEWLRGLSTSRQSFNILFGECPYCSKPITLRMSVRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MZ94</accession>
    <name>A0A8C2MZ94_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanylate binding protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Guanylate-binding protein 2 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">LOC100765968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003515496.4">
        <property type="nucleotide sequence ID" value="XM_003515448.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251665.1">
        <property type="nucleotide sequence ID" value="XM_027395864.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MZ94"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030313.1">
        <property type="protein sequence ID" value="ENSCGRP00001026067.1"/>
        <property type="gene ID" value="ENSCGRG00001023495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765968"/>
    <dbReference type="KEGG" id="cge:100765968"/>
    <dbReference type="GeneTree" id="ENSGT00940000162297"/>
    <dbReference type="OrthoDB" id="2135133at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106139">
        <property type="term" value="C:symbiont cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020005">
        <property type="term" value="C:symbiont-containing vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140970">
        <property type="term" value="P:AIM2 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035458">
        <property type="term" value="P:cellular response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051715">
        <property type="term" value="P:cytolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042832">
        <property type="term" value="P:defense response to protozoan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051673">
        <property type="term" value="P:disruption of plasma membrane integrity in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160075">
        <property type="term" value="P:non-canonical inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140973">
        <property type="term" value="P:positive regulation of AIM2 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140639">
        <property type="term" value="P:positive regulation of pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:symbiont entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16269">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1000.10:FF:000001">
        <property type="entry name" value="Guanylate binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000422">
        <property type="entry name" value="Guanylate-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037684">
        <property type="entry name" value="GBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="8">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027251665.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="67047" checksum="C526F275FAA257CB" modified="2022-01-19" version="1">MASEIHMLDPMCLIENTEDQLVINQQALGILSAIQQPVVVVAIVGLYRTGKSYLMNKLAGKKTGFSLGSTVQSHTKGIWMWCVPHPQKSGHTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFIYNSIGTINQQAMDQLHYVTELTDLIKSKSSPEQSGVDDSANFVGFFPTFVWALRDFSLELEANGKSITADEYLEHSLTLKKGSDKKSENFNKPRLCIRKFFPKRKCFVFDRPAQRKYLSKLETIREEELSGEFVEQVAEFTSYIFTYSNVKTLSGGIIVNGPRLQSLVLTYVNAIRSGELPCMENAVLTLAQIENSAAVQKAIEHYEEQMNQKVHLPTETLQELLDLHRPIESEAIEVFIKNSFKDVDQKFQKKLGDQLVAKRDAFIKKNMDVSSARCSDLLEDIFGPLEEEVKQGTFSKPGGYYLFLQKKQELEKKYNQAPGKGLQAEEMLKKYFESKDDVAETLLKTDQSLTEAAREIEVERIKAEAAEATNRDLAEKQKKYELMMAEKEKSYQEHVKQLTEKMQQEREQLIAENEKIISLKLKEQERLLKEGFQNESRKLHQEIESIKKSQSSGKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N8C6</accession>
    <name>A0A8C2N8C6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9 10" type="primary">LOC100753172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9 10">17A/GY</strain>
            <tissue evidence="9 10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GST superfamily. Alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027248595.1">
        <property type="nucleotide sequence ID" value="XM_027392794.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248596.1">
        <property type="nucleotide sequence ID" value="XM_027392795.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N8C6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030683.1">
        <property type="protein sequence ID" value="ENSCGRP00001026437.1"/>
        <property type="gene ID" value="ENSCGRG00001023755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753172"/>
    <dbReference type="KEGG" id="cge:100753172"/>
    <dbReference type="GeneTree" id="ENSGT00940000163367"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046223">
        <property type="term" value="P:aflatoxin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001657">
        <property type="term" value="P:ureteric bud development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03208">
        <property type="entry name" value="GST_C_Alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03077">
        <property type="entry name" value="GST_N_Alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000005">
        <property type="entry name" value="Glutathione S-transferase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003080">
        <property type="entry name" value="GST_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF107">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01266">
        <property type="entry name" value="GSTRNSFRASEA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027248595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027248596.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25243" checksum="7C93F6F6D1350545" modified="2022-01-19" version="1">MPGKPVLHYFNGRGRMEPVRWLLAAAGVEFEEKFLKTRDDLARLRNDGSLMFQQVPMVEIDGMKLVQTKAILNYIASKYNLYGKDIKERALIDMYSEGVADLELMVLYFPHMPPGEKDAALATIKDKARNRYFPAYEKVLKSHEQDYLVGNRLSRADVSLVELLYHVEELDPSALANFPLLEALRTRVSNLPTVKKFLQPGSQRKPFDDAKCVESTKTIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EX92</accession>
    <name>A0A9J7EX92_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Lanosterol 14-alpha demethylase</fullName>
            <ecNumber evidence="24">1.14.14.154</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">CYPLI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Cytochrome P450 51A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Cytochrome P450-14DM</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Cytochrome P450LI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="47" type="primary">LOC100762189</name>
    </gene>
    <organism evidence="46 47">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="46" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="46">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="46" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="46">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="47" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="47">17A/GY</strain>
            <tissue evidence="47">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="30">Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis. Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:45960"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:45961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxy-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75079"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87057"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:75080"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>32-hydroxy-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxo-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75087"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87057"/>
            <dbReference type="ChEBI" id="CHEBI:87060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:75088"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>32-oxo-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75083"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
            <dbReference type="ChEBI" id="CHEBI:87060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:75084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 43">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="23">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 44">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="24"/>
    <dbReference type="RefSeq" id="XP_027245614.1">
        <property type="nucleotide sequence ID" value="XM_027389813.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EX92"/>
    <dbReference type="GeneID" id="100762189"/>
    <dbReference type="KEGG" id="cge:100762189"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000027">
        <property type="entry name" value="lanosterol 14-alpha demethylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 43 44" id="KW-0349">Heme</keyword>
    <keyword evidence="16 43 44" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20 45" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 43 44" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0492">Microsome</keyword>
    <keyword evidence="18 44" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="15 44" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="17" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="21" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 45" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 45" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="45">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="43">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00037887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00041158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00042370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00042628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00043041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00043156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00046178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00047983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="47">
        <source>
            <dbReference type="RefSeq" id="XP_027245614.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56741" checksum="A23B3836DC49CC51" modified="2023-06-28" version="1">MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNAVFLEQKKMLKSGLNIAHFKQYVSIIEKETVEYFQSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIKKRRQSEEKVDDILQTLLDSTYKDGNPLTDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQEKCFLEQKAVCGEDLPPLTYEQLKDLNLLDRCIKETLRLRPPIMTMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFPSVNYTTMIHTPENPVIRYKRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F0Y2</accession>
    <name>A0A9J7F0Y2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Srpk1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027244845.1">
        <property type="nucleotide sequence ID" value="XM_027389044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F0Y2"/>
    <dbReference type="GeneID" id="100764390"/>
    <dbReference type="KEGG" id="cge:100764390"/>
    <dbReference type="CTD" id="6732"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000761">
        <property type="entry name" value="SRSF protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000105">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF4">
        <property type="entry name" value="SRSF PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="132"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="290"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027244845.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="78348" checksum="3AD7F8F1785FD8C1" modified="2023-06-28" version="1">MRTGFGRLPPQPHPATHGFFLGCWMDRPPGTMWKGAGAPGPPGRSSSPDPLQRTGAYAAPLPNSIEEAPVWAGGRSRPETQHRGSAPHSESDIPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNDQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVETPLTENPPNKMTQEKLEDSSSSGQDQTLTECAVEGGDTEINCNGVIGVVNYTENSNNETLRLKEDLRNANDCRVHTLKQEASFLTSPNGDSSASPETDSCTPVTSEVSETMVCQASSVEQDISHLQESIRAEIPSGDEQEQEHNGPLDNKGKFTAGNFLINPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FB85</accession>
    <name>A0A9J7FB85_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DAP3-binding cell death enhancer 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">DAP3-binding cell death enhancer 1, long form</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Death ligand signal enhancer</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Dele1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR. Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homooctamer; oligomerization is required to activate EIF2AK1/HRI. Interacts (via TPR repeats) with EIF2AK1/HRI; activating the protein kinase activity of EIF2AK1/HRI, thereby promoting the integrated stress response (ISR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with DAP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the DELE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007647006.1">
        <property type="nucleotide sequence ID" value="XM_007648816.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253832.1">
        <property type="nucleotide sequence ID" value="XM_027398031.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FB85"/>
    <dbReference type="GeneID" id="100774899"/>
    <dbReference type="KEGG" id="cge:100774899"/>
    <dbReference type="CTD" id="9812"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008625">
        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000267">
        <property type="entry name" value="DAP3 binding cell death enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052748">
        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00073284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027253832.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="56383" checksum="236B6432CB68F449" modified="2023-06-28" version="1">MWRLTGLLGRALPRLLAPGFRKATPRPTSSHGPQTTFTTPLLSRPSLDRSGSYDPRRNRDPKCHGWKDAFHWMSAHVSPNTLRDAISWGTLAVLALHLARQIHFHASLGAGPQPAECYSWQSPLYRFLSSSWWRHPHSSLQRHVLPRPDFPTPTYTGLREPRLGQEEPSDQPQCCPSDNSLRAGLNLPEEEPSNFDFLNASGDFTSQAKTTEACPPGEKNEQDKSKALPLEEAVTSIQQLFQLSVAIAFNFLGTENMKTGNDTAAFSYFQKAADRSYSKAQYNVGLCLEYGRGTPRDLRKAILFYHLAAIQGHSLAQYRYARCLLQSSSSLSDPERQRAVSMLKQAADSGLREAQAFLGVLFTKEPHLDEQRAVKYLWLAAKNGDSQSRFHLGVCYERGLGVQRNLGEAVKCYQQSAAVGNEPARERLRTLFNMEAAAPGPINLTMTGLKSFSSPSLCSLNTLLASASGLPHASSTGNLGLLCRSGHLGASQGAPSRTIPSLEMNLMRLGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FLA0</accession>
    <name>A0A9J7FLA0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="6">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">eIF3 p110</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100754077</name>
        <name evidence="6" type="synonym">EIF3C</name>
        <name evidence="6" type="synonym">EIF3S8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Phosphorylated. Phosphorylation is enhanced upon serum stimulation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016819193.1">
        <property type="nucleotide sequence ID" value="XM_016963704.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260467.1">
        <property type="nucleotide sequence ID" value="XM_027404666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FLA0"/>
    <dbReference type="GeneID" id="100754077"/>
    <dbReference type="KEGG" id="cge:100754077"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000461">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="676"/>
            <end position="852"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="888"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
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            <begin position="264"/>
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        </location>
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        <location>
            <begin position="525"/>
            <end position="534"/>
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        <location>
            <begin position="889"/>
            <end position="902"/>
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            <position position="9"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
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        </location>
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        </location>
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        </location>
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            <position position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="39"/>
        </location>
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        </location>
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    </feature>
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            <position position="912"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027260467.1"/>
        </source>
    </evidence>
    <sequence length="916" mass="106077" checksum="68FE0CD7A96BB939" modified="2023-06-28" version="1">MSRFFTTGSDSESESSLSGEELDTKPVSGNYGRRPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDDDGVSAAAFLKKKPESSGDSRKFLKKMDVRSRDDDEDSEDSEDDEEWDTSSTSSDSDSEEEEGKQTVLASKFLKKAPTTEEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRATQIELLQLLVQIASENNLGEGVIVKIKFNIIASLYDYNPNLATYMKPEMWQMCLDCINELMDILVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FRZ5</accession>
    <name>A0A9J7FRZ5_CRIGR</name>
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        <submittedName>
            <fullName evidence="6">Cell cycle progression protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ccpg1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007644752.1">
        <property type="nucleotide sequence ID" value="XM_007646562.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266967.1">
        <property type="nucleotide sequence ID" value="XM_027411166.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FRZ5"/>
    <dbReference type="GeneID" id="100768292"/>
    <dbReference type="KEGG" id="cge:100768292"/>
    <dbReference type="CTD" id="9236"/>
    <dbReference type="OrthoDB" id="9935772at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051990">
        <property type="entry name" value="CCPG1/PBIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28638">
        <property type="entry name" value="CELL CYCLE PROGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28638:SF2">
        <property type="entry name" value="CELL CYCLE PROGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
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        <location>
            <begin position="546"/>
            <end position="565"/>
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    </feature>
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        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
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            <begin position="308"/>
            <end position="452"/>
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            <begin position="133"/>
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            <begin position="176"/>
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    </feature>
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        <location>
            <begin position="594"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027266967.1"/>
        </source>
    </evidence>
    <sequence length="880" mass="100586" checksum="E9250B4DF9CDA0B0" modified="2023-06-28" version="1">MSENSSDSDSSCGWTVINHEGSDVEIMNSATASDNCELTLECSSLEQEELQVLHVGTGGGESIANSMLSVEETRLLSVGETKSAIEVEEATSPEDNMYLGTTSDDSDIVTLEPPKLEEMGNQEVIIKEAPNSEDFNMGSSSSSQYTFCQPESVFSSQPSDEESSSDDTSHEPSPVPRRRRNRKKTVSVSESEEPPLAEPEDEPSKEPSKRHFSGGLNKCVILALVIAVSMGFGHFYGTIQIQKHHQLVRKIHRDELTDMKDYLSQCQQEQESFLDSKSLKENLERCWTVTDAEKVTFETQKKNLAAENQYLRISLEKEEKALSSLQEELRRLREQIRLLEDKGTSSQLVKENQALQQNLEVEKEKTNSFLNERETLLEEAKMLKRDLERERLTAMALRAELEQLGPCQAQDHTDSPNVQTEEKEVVLLQQRLAELEQKLTFEQQRSDLWERLYVEAKDQNGKLETEGRKRGSRGNPRAKSKSKETFLGTVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGSKRFGPSKEAAAEKPRTAYGYSSYSLHEALNQKQNCRGPSAQSKGGREKPSHTEESRKNANSDTHKAKFDFRDTHSTRRVFPGMFECAGQESGSSVNAASPVRINDFRQLIQWYLLNELDTFHHWKELDQFISPFFPNGVFRHDQKLFTDFVDAVKGYLKGIKEYQVEDDSLEKLDRYIYRHFGHIFALPFGPSRPDKKQQRMVNIENSRHRKQEQKHLHPQPYKREALGSTCNQSITEFCLHCKGPHNQMYQVFRPVGDALVRAEMQPNGRAIQALLTKRSEEICCPWSIATLRLSTTCCHNAWETDSSSTGFCYVPWDCWRIVYLSANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FV35</accession>
    <name>A0A9J7FV35_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100774791</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269130.1">
        <property type="nucleotide sequence ID" value="XM_027413329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FV35"/>
    <dbReference type="GeneID" id="100774791"/>
    <dbReference type="KEGG" id="cge:100774791"/>
    <dbReference type="OrthoDB" id="9615015at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027269130.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34488" checksum="AEB5274CE626865E" modified="2023-06-28" version="1">MEGNRTLLTEFVLRGITDRPELQVPLFLVFFFIYVVTMVGNLGLIFLIWKDTHLHTPMYLFLGNLAFADACISTTVTPKMLMTFLNKNDIITLGECFAQYYFFCISATTEIFLLVAMAYDRYVAICNPLHYVVVMSKRLCTVLISMSYIIGFVNCGLNVGLLFRLTFCKSNIIDHFYCEILPLYTISCTDPSLNTLIIFICASSIQISTSVTIVVSYARVLFAVVNMKSKKGRQKAFFTCSAHLLSVSLFYGTLLFMYVSHGSGPGKQQDKIYSLFYTVVIPLLNPFIYSLRNKEVLGALKNVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GBI0</accession>
    <name>A0A9J7GBI0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Heat shock protein 75 kDa, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">TNFR-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tumor necrosis factor type 1 receptor-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Trap1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279826.1">
        <property type="nucleotide sequence ID" value="XM_027424025.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GBI0"/>
    <dbReference type="GeneID" id="100763701"/>
    <dbReference type="KEGG" id="cge:100763701"/>
    <dbReference type="CTD" id="10131"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000021">
        <property type="entry name" value="Heat shock protein 75 kDa, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000004">
        <property type="entry name" value="Heat shock protein 75 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0346">Stress response</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="20">
        <location>
            <begin position="110"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="202"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027279826.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="80294" checksum="D0A754AC530DB00A" modified="2023-06-28" version="1">MARELRAVLLWGRGLQTTLRAPALAGVRRGKPVLHLQRTTVQVKGRIQCLASRISTGQLYSTQAAEDKKEEALHSIINSTEAVQGSVSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSEGQVLPEMEIHLQTDAEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLEALQNQAETSSKIIGQFGVGFYSAFMVADKVEVYSRSAAPDSPGYQWLSDGSGVFEIAEASGVRPGTKIIIHLKSDCKDFANESRVQDVVTKYSNFVSFPLYLNGRRINTLQAIWMMDPKDISELQHKEFYRYVAQAYDKPRFTLHYKTDAPLNIRSIFYVPETKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFVRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFLDQSKKDAEKYAKFFEDYGLFMREGIVTTAEQNIKEDIAKLLRYESSALPAGQLTSLSDYASRMQAGTRNIYYLCAPNRHLAEHSPYYEAMKQKQTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDTSPAGECLPEKETEELMAWMRNALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHTLIKKLSQLREREPELAQLLVDQIYENAMIAAGLVDDPRPMVGRLNDLLVKALEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GCM6</accession>
    <name>A0A9J7GCM6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Coro6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282472.1">
        <property type="nucleotide sequence ID" value="XM_027426671.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GCM6"/>
    <dbReference type="GeneID" id="100756161"/>
    <dbReference type="KEGG" id="cge:100756161"/>
    <dbReference type="CTD" id="84940"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000003">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF23">
        <property type="entry name" value="CORONIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027282472.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52682" checksum="54ECC3114106ABA1" modified="2023-06-28" version="1">MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSAFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRVDKNYPLVTGHTGPVLDIDWCPHNDNVIASASDDTTVMVWQIPDYTPVRNITEPVITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEALLSLDDIHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKNQVVAERARPHEGARPLRAVFTADGKLLSTGFSRMSERQLALWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYLNTFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLKEGYVPPKHRELRVTKRNILDVRPPAGPRRSQSASEAPLSQQHTLETLLEEIKALRERVQAQEERITALENMLCELVDGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GD27</accession>
    <name>A0A9J7GD27_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Telomerase Cajal body protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">WD repeat-containing protein 79</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">WD40 repeat-containing protein antisense to TP53 gene homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Wrap53</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="16">Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. Interacts with the chaperonin-containing T-complex (TRiC) complex; which mediates the folding of WRAP53/TCAB1. Interacts with COIL. Interacts with SMN1. Interacts with RNF8. Interacts with histone H2AX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TCAB1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282827.1">
        <property type="nucleotide sequence ID" value="XM_027427026.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GD27"/>
    <dbReference type="GeneID" id="100757087"/>
    <dbReference type="KEGG" id="cge:100757087"/>
    <dbReference type="CTD" id="55135"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000453">
        <property type="entry name" value="Telomerase Cajal body protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027282827.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="61275" checksum="140481B023BF8CAE" modified="2023-06-28" version="1">MGGESPYPSIPRETAGTKLDSRHDKMKTSEERLLVPDSLSSDQAPAPVPQGTPVDENTDSEPVPPPCGGDDRPQVATDSVAGSVVFQDPQQGDLVPPSAPLEVGFNTPGESSPRIEEQELSENASLPVTETNRPELESGEAVEDVSEEPGQVDEGDTFWTYSFSQVPRYLSGSWSEFSTHSENFLKGCKWAPDGSCILTNSADNTLRIYNLPPELYSEAEQVDYAEMVPVLRMVEGDTIYDYCWYSLMSSSQPDTSYVASSSRENPVHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTSRPGRDCEVRATFAKKQGQSGIISCIAFSPSQPLYACGSYGRTLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARKDAELLCWDLRQPGHLLWSLSREVTTNQRIYFDLDPSGQFLVSGNTNGMVSVWDINGAVSDSKLGPVMTFLPQKDCTNGVSLHPSLPLLATASGQRMFPEPTNSGDEGEPEGDLPLLSLCHAHPEWRLQLWWCGGGPDPSSPNDHQDEKGQGRTEGCGDELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GE19</accession>
    <name>A0A9J7GE19_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Smurf2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation. SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003501922.1">
        <property type="nucleotide sequence ID" value="XM_003501874.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283581.1">
        <property type="nucleotide sequence ID" value="XM_027427780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GE19"/>
    <dbReference type="GeneID" id="100773704"/>
    <dbReference type="KEGG" id="cge:100773704"/>
    <dbReference type="CTD" id="64750"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000047">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000024">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000007">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF300">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SMURF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 15 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="8"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="20">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="20">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="20">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="21">
        <location>
            <begin position="430"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16 17">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027283581.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="87921" checksum="B2E4E41C0582B79C" modified="2023-06-28" version="1">MSTTYENSRAFHSVTILLLPLGIALILLQMLVAVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDTTGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GFM5</accession>
    <name>A0A9J7GFM5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fanconi anemia group D2 protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Fancd2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027284907.1">
        <property type="nucleotide sequence ID" value="XM_027429106.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100757761"/>
    <dbReference type="KEGG" id="cge:100757761"/>
    <dbReference type="CTD" id="2177"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11721">
        <property type="entry name" value="FANCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="854"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1418"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027284907.1"/>
        </source>
    </evidence>
    <sequence length="1470" mass="166793" checksum="CD8CE513F0CAA9EE" modified="2023-06-28" version="1">MVSKRRRLDSENRETVTEDASKIMKQPLSKLARKSYDSHEVEENGSIFVRLLKTSGLTLKTGENQNQLGVDQIIFQRKLFQALRKHPSYPKIIEEFVNGLESYIEDCDCLRNCLLSCERLQDEEASTGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFENESNDGINMSRLIINQLKWLDRIVDSKDLTAQMMQLISVAPLNLQHDFITSLPEILVDSQHANVGKELSKLLAQNTSLTVPILDVFSSLRLDSNFLSEIRQLVMGKLSSVQLEDLPVIVKFILHSVTDTTSLEVISELREKLNVQHFILPSRVQASQSKLKSKGLASSSGNQENSDKDCVILVFDVIKSAIRYEKAISEAWIKAIERIESVTEHKALDVAMLLIIYSTSTQTKKGSEKVLRNKIQSGCIQEQLLEGTFSTHYMVLKDICPSILLLAQTLFHSQDQRIILFGSLLYKYAFKIFDTYCQQEVVGALVTHVCSGNEAEVDTALDVLLELIALNPSAMRLNAVFVKGILDYLETMSPQQIRKIFCILSTLAFSQQPGTSNHIQDEMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRSVPSNSTQRRADLSSEWCTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVGQTIFNDFQDAFVVDFCAIPEGDFPFPVKALYGLEESSTQDGIVINLLPLFFQEFAGVSQMTSQESSQKSMSSLCLASHFRLLRLCVARQHNGNLDEIDGLLDCPLFLPDLEPGEKLESMSAKERSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVIPDYVPPFANVDMDTLDMIPKSSSAVSTKNRNKGKMGGRKQKADISKASSTETLLTEDTSECDTVTSGRSPVEKVLEYVTKESAGKEGKTFVSLQNYHAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENVLTPSFAKRLCFLKNKGNRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNYFQVRRLSYYKTRNHSLGAEHLSVDDKPRVKAQEQHTMSSCYQKLLQIFYTLFAWKGFTHHSNLHLLHSALEVLTSRLKQTEQEQPLEELISQSFNYLQNFHHCIPNFQCGLYLLRLLMTLLEKSAAPTQKKEKLATLAKQLLCRAWPHGEKEKNTNFNDHLHDLLCIYLEHTDNVLKAIEEIAGVGVPELVNAPKDASSSTFPMLTRHTFVIFFRVMMAELEKTVKSLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRHFVEAFLKQCMPLLDFCFRKHREDVLSLLETLQRNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIVSQHLSSPESTSEDSESGMTSHVSRDRATQDGEDEASDGQKDQDNDESDDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GG74</accession>
    <name>A0A9J7GG74_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclin-dependent kinase-like 3</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19 20 21 22 23" type="primary">Cdkl3</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19 20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19 20">17A/GY</strain>
            <tissue evidence="18 19 20">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027283366.1">
        <property type="nucleotide sequence ID" value="XM_027427565.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283367.1">
        <property type="nucleotide sequence ID" value="XM_027427566.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283368.1">
        <property type="nucleotide sequence ID" value="XM_027427567.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283371.1">
        <property type="nucleotide sequence ID" value="XM_027427570.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283372.1">
        <property type="nucleotide sequence ID" value="XM_027427571.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283373.1">
        <property type="nucleotide sequence ID" value="XM_027427572.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GG74"/>
    <dbReference type="GeneID" id="100757962"/>
    <dbReference type="KEGG" id="cge:100757962"/>
    <dbReference type="CTD" id="51265"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097484">
        <property type="term" value="P:dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030517">
        <property type="term" value="P:negative regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050775">
        <property type="term" value="P:positive regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000370">
        <property type="entry name" value="cyclin-dependent kinase-like 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF177">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="442"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="544"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="462"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00047811"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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    </evidence>
    <sequence length="589" mass="67137" checksum="336B281348243FDC" modified="2023-06-28" version="1">MEMYETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSTSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPAERISSTDLLRHEYFTRDGFIEKFIPELRAKLLQEAKVNSFVKPRENFKENEPMRDEKKPIFTNTVLYGKEMDKDKKPKEIKVRVIKVKGGKGDVPDLKKTECEGEHRQQGTADDTHALSQDRKPAITEVLNPVNPSTNSDGASEDLHAGGCMIMPPINLTSSNLMAANLNSNLSHPNSRLTERAKKRRTTSQTIGQTLSNSRQEDTGPTQSQTEKSVFNDRTGQSDQMASGNKRKLNFSRCDRKEFHFPELPFTIQAKEMKGMEVKQIKVLKRESKKTDSPKIPTLLTVDPNQEKQEGGDGDGEGKNLKRNRFFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GHY3</accession>
    <name>A0A9J7GHY3_CRIGR</name>
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        <name evidence="3" type="primary">LOC100759352</name>
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        <name type="scientific">Cricetulus griseus</name>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
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        </source>
    </reference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
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        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
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            <begin position="63"/>
            <end position="131"/>
        </location>
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            <begin position="101"/>
            <end position="124"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027286175.1"/>
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    </evidence>
    <sequence length="131" mass="14484" checksum="F2431F7D3A592137" modified="2023-06-28" version="1">MDPVGCFGVLLWHGHRDHHDSTQPLKTKRSIPQCGKSFHSTAPVPPRWCRGRLHDQDLRRTAEKRCQTQPLQQRLQECGPPRPPSPGGAEDGGKGPRWGPQANTSGTERSGQNCRTGGSCQQEALEQRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GIA3</accession>
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        <submittedName>
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        <name evidence="10" type="primary">Snx12</name>
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    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511097.4">
        <property type="nucleotide sequence ID" value="XM_003511049.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287591.1">
        <property type="nucleotide sequence ID" value="XM_027431790.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GIA3"/>
    <dbReference type="GeneID" id="100756869"/>
    <dbReference type="KEGG" id="cge:100756869"/>
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    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051223">
        <property type="term" value="P:regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07294">
        <property type="entry name" value="PX_SNX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000002">
        <property type="entry name" value="Sorting nexin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF3">
        <property type="entry name" value="SORTING NEXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="152"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027287591.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22574" checksum="CDF8C601D4554FD9" modified="2023-06-28" version="1">MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVPGKVILILEACQNRLLKGGSHFLFMNPNKAPTPSSICMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GKF1</accession>
    <name>A0A9J7GKF1_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: phosphatidylinositol N-acetylglucosaminyltransferase subunit Y-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC100756881</name>
    </gene>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
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    <dbReference type="KEGG" id="cge:100756881"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027288412.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8015" checksum="FAF1C773A234EBEE" modified="2023-06-28" version="1">MFPSLPTLRILIPLGSLSGQLYSATVEEGFPXGCSSASNLCFYRLLLLGIVPAYIFSRLWTWMELKLFRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GLF6</accession>
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        <recommendedName>
            <fullName evidence="14">C-terminal-binding protein 2</fullName>
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        <name evidence="19" type="primary">LOC100762805</name>
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    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294639.1">
        <property type="nucleotide sequence ID" value="XM_035438748.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311349.1">
        <property type="nucleotide sequence ID" value="XM_035455458.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762805"/>
    <dbReference type="KEGG" id="cge:100762805"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048386">
        <property type="term" value="P:positive regulation of retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001383">
        <property type="entry name" value="C-terminal-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF3">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="16">
        <location>
            <begin position="44"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="17">
        <location>
            <begin position="141"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035294639.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49820" checksum="D024B205DDAE7D74" modified="2023-06-28" version="1">MALVDKHRVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVNVRIGSGYDNVDIKAAGELRIAVCNIPSAAVEETADSTVCHILSLYRRNTWLSQDLREGTWVQSVEQIREVASGAARIRGETLGLIGFGRTGQAIAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYILQDLLYQSNCVSLYCNRNEHNHHLINDFTIKQMRQGAFLVNAXLVDEKALAQALKEGRIRGAALDVHKSEPFSFAQGPLKDAPNLICTLHTAWYSEQASLQMREAAAATEIRRAITGRIPESLRNCVNKKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGMAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAEARRFRSSAILLSGKSWTRRVQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GT46</accession>
    <name>A0A9J7GT46_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC100768185</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035292640.1">
        <property type="nucleotide sequence ID" value="XM_035436749.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298768.1">
        <property type="nucleotide sequence ID" value="XM_035442877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GT46"/>
    <dbReference type="GeneID" id="100768185"/>
    <dbReference type="KEGG" id="cge:100768185"/>
    <dbReference type="OrthoDB" id="9610409at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="13 14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="16">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035298768.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13980" checksum="7198C2CC89F5BD20" modified="2023-06-28" version="1">MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GVN3</accession>
    <name>A0A9J7GVN3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sperm flagellar protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100770663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035292532.1">
        <property type="nucleotide sequence ID" value="XM_035436641.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298019.1">
        <property type="nucleotide sequence ID" value="XM_035442128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GVN3"/>
    <dbReference type="GeneID" id="100770663"/>
    <dbReference type="KEGG" id="cge:100770663"/>
    <dbReference type="OrthoDB" id="193300at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000059">
        <property type="entry name" value="RIKEN cDNA 6430531B16 gene"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF14">
        <property type="entry name" value="SPERM FLAGELLAR 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035298019.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34976" checksum="11CCC32FC232305F" modified="2023-06-28" version="1">MFSTSKQSSAEFLPTPEDIHNLCAWLDRLPLSRPKRHLARDFSDGVLVAEIVKYFHPRLVDLHSYVPACSTDQKLSNWSLLNRQVFRKLHFCISEADIQKVVSNRPGVIESVLCALREKMEASTVHVGSAGAADPGLSSVDAVRPWAGHTTHPHTTRTQDLNVDNCSLSEPLWDSHGERHYIPESWTHDNHELTNLHKRAGQQSPTAPFSMKTLQNQRDLEKMGCCSCRGDPVEGLWDHLASIQQQLEDKEQALAILQETVKILQMKVMRLEYLVQLKDQRIWELMRPGPDERQMWRGPHPESFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H0N3</accession>
    <name>A0A9J7H0N3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100764614</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303357.1">
        <property type="nucleotide sequence ID" value="XM_035447466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H0N3"/>
    <dbReference type="GeneID" id="100764614"/>
    <dbReference type="KEGG" id="cge:100764614"/>
    <dbReference type="OrthoDB" id="5818798at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035303357.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15052" checksum="74DF3C7AB80502CE" modified="2023-06-28" version="1">MADSKYKPAPLATLPSTLDPAKYDLSPETRKAQIERLSIRARLKLEYLLQYNDPKRQMHIEDAALIHWAYARSTNIYPNFRPTPKNSLLGVVAAFGPLIFWYYIFKTDRDKKENLIQEGKLDQTFKLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H0T8</accession>
    <name>A0A9J7H0T8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 29">Cholesterol side-chain cleavage enzyme, mitochondrial</fullName>
            <ecNumber evidence="6 29">1.14.15.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Cholesterol desmolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">LOC100752606</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22 29">A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(20R,22R)-20,22-dihydroxycholesterol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 4-methylpentanal + pregnenolone + 2 oxidized [adrenodoxin] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34343"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:1294"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16581"/>
            <dbReference type="ChEBI" id="CHEBI:17998"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:34344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(22R)-hydroxycholesterol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized [adrenodoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:34339"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:1294"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:67237"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:34340"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (22R)-hydroxycholesterol + 2 oxidized [adrenodoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:34335"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:67237"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:34336"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:35739"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:16581"/>
            <dbReference type="ChEBI" id="CHEBI:17998"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:35740"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27 29">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 29">Lipid metabolism; C21-steroid hormone metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Steroid metabolism; cholesterol metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with FDX1/adrenodoxin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="29">Mitochondrion inner membrane</location>
            <topology evidence="29">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="29">Localizes to the matrix side of the mitochondrion inner membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 28">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.6" evidence="6 29"/>
    <dbReference type="RefSeq" id="XP_035300291.1">
        <property type="nucleotide sequence ID" value="XM_035444400.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311727.1">
        <property type="nucleotide sequence ID" value="XM_035455836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H0T8"/>
    <dbReference type="GeneID" id="100752606"/>
    <dbReference type="KEGG" id="cge:100752606"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008386">
        <property type="term" value="F:cholesterol monooxygenase (side-chain-cleaving) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006700">
        <property type="term" value="P:C21-steroid hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071375">
        <property type="term" value="P:cellular response to peptide hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034650">
        <property type="term" value="P:cortisol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006704">
        <property type="term" value="P:glucocorticoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF3">
        <property type="entry name" value="CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 29" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="9 27 28" id="KW-0349">Heme</keyword>
    <keyword evidence="14 27 28" id="KW-0408">Iron</keyword>
    <keyword evidence="16 29" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 27 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 29" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15 28" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20 29" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="21 29" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="19 29" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="12 29" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" description="axial binding residue" evidence="27">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="RuleBase" id="RU364077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_035300291.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="50026" checksum="503B3E760B70686C" modified="2023-06-28" version="1">MESVYILDPEDAALLFSCEGPYPERYLVPPWVAYHQYYKRPIGVLFKSSDAWKRDRLVLNQEVMAPEAIKNFVPLLETVVRDFIDVLHRRIKQQKSGNFSGDISGDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNLPPELFRFFRTKTWKEHAAAWDVIFEKAHDYTKNFYWDLRQKQEYSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLEVQEMLRAEVLAARRQAQGDMVKMVQLVPLLKASIKETLRLHPISVTLQRYLADDLVLRNYRIPAKMLVQVANYAMGRVPSFFPNPNKFDPTRWLEKSKNITHFRYLGFGWGIRQCLGRRIAELEMTIFLINVLENFRIEVQSFHDVGTKFNLILMPEKPIFFNFHPLKKDLGTTMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H1U5</accession>
    <name>A0A9J7H1U5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Estrogen receptor beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nuclear receptor subfamily 3 group A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Esr2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300996.1">
        <property type="nucleotide sequence ID" value="XM_035445105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H1U5"/>
    <dbReference type="GeneID" id="100763291"/>
    <dbReference type="CTD" id="2100"/>
    <dbReference type="OrthoDB" id="5799427at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002064">
        <property type="term" value="P:epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:intracellular receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07171">
        <property type="entry name" value="NR_DBD_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000010">
        <property type="entry name" value="Estrogen receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000014">
        <property type="entry name" value="Estrogen receptor beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021064">
        <property type="entry name" value="ER-beta-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12497">
        <property type="entry name" value="ERbeta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 15 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="17">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="18">
        <location>
            <begin position="283"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035300996.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="75044" checksum="C9B775534C6669E6" modified="2023-06-28" version="1">MSVCMSSHKDFSQLLPVQDMDIKNSPSSLNSPVSYNCSQSILPLEHGPIYIPSSYVENRHEYSAMAFYSPAVMNYSVPSSASNLEGGPVRQTTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWYEARSLEHTLPVNRETLKRKLSGGSCASPVTSPSSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQMHCLSKAKRNSGHVPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRSSEDPHWHVAQMKSAAPRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLATANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHIRWLRNTEEHGSPSRTVKIKHNRISAGLSEADCSQHKHADAGREPIPRMAERTHSAATISPVISIVTKTERHRDSSGCLGRGCSCQLKWYLLFMRKNHSLGFSGSSKFPAAPLPPGQAAPPPAQPALFIHWLTIFQPGPPQGSSSEAPAPAGLPAQGSRWKQDTFSTLCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2E9</accession>
    <name>A0A9J7H2E9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase VRK1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Vaccinia-related kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26" type="primary">Vrk1</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25 26">17A/GY</strain>
            <tissue evidence="25 26">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with HDAC1, KAT2B, SETDB1, KDM3A and KDM4A. Associates with the nucleosome through interactions with nucleosome DNA, histone H2A and histone H2B; the interaction with H2A and H2B is mediated by the nucleosome acidic patch, a cluster of negatively charged residues of H2A and H2B forming a cleft within the nucleosome core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035301372.1">
        <property type="nucleotide sequence ID" value="XM_035445481.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301373.1">
        <property type="nucleotide sequence ID" value="XM_035445482.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312316.1">
        <property type="nucleotide sequence ID" value="XM_035456425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H2E9"/>
    <dbReference type="GeneID" id="100761272"/>
    <dbReference type="CTD" id="7443"/>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14122">
        <property type="entry name" value="STKc_VRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000348">
        <property type="entry name" value="serine/threonine-protein kinase VRK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 25 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="37"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="398"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035301372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_035301373.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49488" checksum="B1418816F732FF37" modified="2023-06-28" version="1">MPRVKAAQAGRQGPAKRRLAEQFAAGEIITDMSKKEWKLGLPIGQGGFGCIYLADTNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIHTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANARRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPDGVHKEYKEDPKRCHDGTLEFTSIDAHNGVAPSRRGDLEILGYCMIQWLSGCLPWEDNLKDPNYVRDSKIRYRDNVAALMEKCFPEKNKPGEIAKYMETVKLLDYTEKPVYQDLRDILSQGLKAIGSKDDGKLDFSAVENGSMETEPASKMRPLAFHSTPSFCFSPQNKRKKEAEDSTVCGVEDMECSDTPVGYAIQTRSEESQGAMHGSMSQPEASCSSSDSSRTRKKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HA46</accession>
    <name>A0A9J7HA46_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Skin-specific protein 32 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CUNH1orf68</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035307595.1">
        <property type="nucleotide sequence ID" value="XM_035451704.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314773.1">
        <property type="nucleotide sequence ID" value="XM_035458882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HA46"/>
    <dbReference type="GeneID" id="100756558"/>
    <dbReference type="KEGG" id="cge:100756558"/>
    <dbReference type="CTD" id="100129271"/>
    <dbReference type="OrthoDB" id="9449064at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035307595.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="25742" checksum="B38D1F2A722B1B3D" modified="2023-06-28" version="1">MCDQQKQPQFLPSCVKGSGLGAGQGSSGTLGKGQVSGPVQTVYAPGPALYQPQTIVRYSAPVPAPAYVKYQVPCQTKTYVKCPAPCQTYVKCPAPCQTTYVKCPAPCQTTCVKCPAPCQTQTYYVQYAVPTQTYYTQASSSGSGSQGGVPDPCSAPCSMSYCCLAPRTFGVSPLRRWVQRPQGWNTGSSSCCEDSGCCGSGGCGSGGCGSGGCGGCGSGGCGGCGCGSGCCCLGIIPMRSRGPACCDSGDDCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HET9</accession>
    <name>A0A9J7HET9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein 431-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118239763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035309451.1">
        <property type="nucleotide sequence ID" value="XM_035453560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HET9"/>
    <dbReference type="GeneID" id="118239763"/>
    <dbReference type="KEGG" id="cge:118239763"/>
    <dbReference type="OrthoDB" id="9585558at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF151">
        <property type="entry name" value="EXPRESSED SEQUENCE AW146154-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035309451.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8761" checksum="827749B811963A7E" modified="2023-06-28" version="1">MDEHRSHSMDTVTYDSVCIKFTQEEWSLLDPSQKSLYKDVMLDTYRNLSAIGYIWEECNIEEHCESFRRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J2I6</accession>
    <name>A0A9J7J2I6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Natural cytotoxicity triggering receptor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Natural killer cell p30-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Ncr3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the natural cytotoxicity receptor (NCR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027244645.2">
        <property type="nucleotide sequence ID" value="XM_027388844.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315769.1">
        <property type="nucleotide sequence ID" value="XM_035459878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J2I6"/>
    <dbReference type="GeneID" id="100772283"/>
    <dbReference type="KEGG" id="cge:100772283"/>
    <dbReference type="CTD" id="259197"/>
    <dbReference type="OrthoDB" id="9950892at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002429">
        <property type="term" value="P:immune response-activating cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030101">
        <property type="term" value="P:natural killer cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045954">
        <property type="term" value="P:positive regulation of natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043226">
        <property type="entry name" value="NCR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47904">
        <property type="entry name" value="NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47904:SF1">
        <property type="entry name" value="NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039935047" description="Natural cytotoxicity triggering receptor 3" evidence="16">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027244645.2"/>
        </source>
    </evidence>
    <sequence length="211" mass="22547" checksum="C24D31B327B639DD" modified="2023-06-28" version="1">MAKALLLICIMVYPGSCVLWVSQPLEIRVQEGAPALLPCSFNASRGAVAIGSVTWYQDKVAPGMEVRNMTPEFRGRVASFAVVPRFIRDHTAELLIRDTQSHDTGIYVCRVEVLGLGVGTGNGTRLVVEKEPPQQASSSEQVTHVSLLLRAGFYALGFLSVAIGSALYYQGKSGLTSKSPGTDLLAPPHPPVLGSEAMAAAAEKRRLSEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J4H3</accession>
    <name>A0A9J7J4H3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Centaurin-gamma-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phosphatidylinositol 3-kinase enhancer</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Agap2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027248054.1">
        <property type="nucleotide sequence ID" value="XM_027392253.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J4H3"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="670"/>
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        </location>
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        <source>
            <dbReference type="RefSeq" id="XP_027248054.1"/>
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    </evidence>
    <sequence length="1166" mass="122199" checksum="6542D43DD2FC5DFE" modified="2023-06-28" version="1">MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAGAGAPGARGSEPRDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGAGGAEPPTLSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPFKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASATATGGGGGAAVTTSGGVGAVPGARGKLSPRKGKSKTLDNSDLHPGPTAGSPPLTVPATPVPATCVTTASTQPLGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGPGPLPGPPGLSSSSGSRELLGAELRASPKAVVNSQEWTLSRSIPELRLGVLGDVRSGRSSLIHRFLTGLYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCTEMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGPEATTPMPSPSPSPSSLQLPSDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSTVQAEEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSTCVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPTRDSSREERESWIRAKYEQLLFLAPLGTTEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSTATTPSAATTPSITATPSPRRRSSAASLGRVDATIALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JAA0</accession>
    <name>A0A9J7JAA0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Growth/differentiation factor 8</fullName>
            <shortName evidence="15">GDF-8</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Myostatin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Mstn</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 15">Acts specifically as a negative regulator of skeletal muscle growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003514652.1">
        <property type="nucleotide sequence ID" value="XM_003514604.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252636.1">
        <property type="nucleotide sequence ID" value="XM_027396835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JAA0"/>
    <dbReference type="CORUM" id="A0A9J7JAA0"/>
    <dbReference type="GeneID" id="100770972"/>
    <dbReference type="KEGG" id="cge:100770972"/>
    <dbReference type="CTD" id="2660"/>
    <dbReference type="OMA" id="CNACMWR"/>
    <dbReference type="OrthoDB" id="5948587at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048632">
        <property type="term" value="P:negative regulation of skeletal muscle tissue growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051384">
        <property type="term" value="P:response to glucocorticoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901654">
        <property type="term" value="P:response to ketone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19388">
        <property type="entry name" value="TGF_beta_GDF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000006">
        <property type="entry name" value="growth/differentiation factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.970:FF:000001">
        <property type="entry name" value="Growth/differentiation factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF150">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3 15" id="KW-0202">Cytokine</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0339">Growth factor</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039894747" description="Growth/differentiation factor 8" evidence="16">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="17">
        <location>
            <begin position="264"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027252636.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42891" checksum="6A57D3736247847F" modified="2023-06-28" version="1">MMQKLQMCVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACVWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIHLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JBL7</accession>
    <name>A0A9J7JBL7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DnaJ homolog subfamily B member 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Dnajb14</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003514611.4">
        <property type="nucleotide sequence ID" value="XM_003514563.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251592.1">
        <property type="nucleotide sequence ID" value="XM_027395791.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JBL7"/>
    <dbReference type="GeneID" id="100752201"/>
    <dbReference type="KEGG" id="cge:100752201"/>
    <dbReference type="CTD" id="79982"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000004">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027251592.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42510" checksum="5BBD336A6E6A488D" modified="2023-06-28" version="1">MEGNRDEAEKCVQIAREALSAGNRDKAQRFLQKAEKLYPLPAARALLEIIMKNGNTAGSSTHCRKPPGSGDQSKPTYTKDSNPSSGEGGKVYTKDQVDGVLSINKCKNYYEVLGVTKDAADEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGSEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAAYSHQHQHRHSGHEREEERGDGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGSGQTIKMQTENLGVVYYVSKDFKSEYKGALLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDERLRRKADALSMDNCKELERLTSLYKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JCD5</accession>
    <name>A0A9J7JCD5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Unconventional myosin-Ib</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Myosin I alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Myo1b</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027252660.1">
        <property type="nucleotide sequence ID" value="XM_027396859.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JCD5"/>
    <dbReference type="GeneID" id="100753394"/>
    <dbReference type="KEGG" id="cge:100753394"/>
    <dbReference type="CTD" id="4430"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000007">
        <property type="entry name" value="Myosin-ib isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000004">
        <property type="entry name" value="unconventional myosin-Ib isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF277">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="15"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="17">
        <location>
            <begin position="952"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027252660.1"/>
        </source>
    </evidence>
    <sequence length="1136" mass="132127" checksum="F740734DAEE12450" modified="2023-06-28" version="1">MAKMEVKSSLLDNMIGVGDMVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISMNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNEVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLHKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHETEAVLEVVAAVLKLGNIEFKPESRMNGLDESKIKDKNELKEICELTSIDQLVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEENSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAVICELIENNTNGILAMLDEECLRPGTVTDDTFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSLFPEGNPVKVNLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEILFNELEIPTEEYSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQVVIAAWCRRYAQQKRYQQIKSSTLVVQSYIRGWKARKLLRELKHQKRCKEAATTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAFWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTNQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JDH4</accession>
    <name>A0A9J7JDH4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Vomeronasal type-2 receptor 116-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100766746</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027263737.1">
        <property type="nucleotide sequence ID" value="XM_027407936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JDH4"/>
    <dbReference type="GeneID" id="100766746"/>
    <dbReference type="KEGG" id="cge:100766746"/>
    <dbReference type="OrthoDB" id="9595711at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06365">
        <property type="entry name" value="PBP1_pheromone_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000009">
        <property type="entry name" value="Vomeronasal 2, receptor 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000024">
        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF409">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039909830" evidence="12">
        <location>
            <begin position="26"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="580"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027263737.1"/>
        </source>
    </evidence>
    <sequence length="851" mass="98044" checksum="F165F20D58DD1459" modified="2023-06-28" version="1">MLFLTFVFLVLRLSFLFWSLTGTRCFLRRNDIDSMGQDKDNDCLFSIYTKYGHMKNEYFPRNLDKKLTNKDIHLILSLYFALENINKDPHILPNISLLVKIECNLLDDWRMNSLFSRIDEFLPNYYCINQRRYLIVLTGPTWLSSAMLGPLLYITNRPELYYGPFHPILGSREQFPHLYQMAPKDTALALAMVSLVVYFRWNWVGAIISDDDLGLQFLFELRRETQRNSVCLAFVHIIVEDKILFQKNVNTFYNEIITSSAKVVIIYGDKDSHLQLNLRLYRLVNVQRIWVTTSQWDMITHDDRLLFNSFYGTFTFLLHFSELSGFTAFILAPDPSKYISTWILSELWWIYFNCSPNSFNSMKIKNYSKGKLYNWLFMQKMEMSVSSTGYVLYNTVHAVAHALHEMLLQEVHTWPKYPGEILEFDSWQMVQFLKNIQFMNPVGNQVNMNQKENQDMKYDIHYTMDFLSHIGFKVEVGIFSKHLLHTQQFYVSEEIIKWNIDLRQIQPSICSVPCNPGFRKSPHQGKAVCCFDCTPCPENEISNMTGMDQCVKCPDDYYANPGGNHCLKKVVTFLGYEDLLGMSLACFAVCFSILTAGVLGVFLKYKDTPTVKANNRDLSYVLLISLIFCFLCCLLFIGKPNIITCLMQQTIFAVVFTVAASTVLAKTITVVLAFKVTTPGRRIRRLLLSGAPNFIIPICTMIQLILCGIWLGISPPFVEADVYVEKGHILIICNKGSITAFYCVLGYLGSIALGSFTLAFLARNLPDTFNEAKYLTFSMLVFCSVWITFLPVYHSTKGKAMVGVEVFCILASSAGLLLCIFAPKCFIILLRPERNSFQNFRNMHYKIENTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JEC9</accession>
    <name>A0A9J7JEC9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Taste receptor type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Tas2r1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor T2R family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007639057.2">
        <property type="nucleotide sequence ID" value="XM_007640867.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255800.1">
        <property type="nucleotide sequence ID" value="XM_027399999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JEC9"/>
    <dbReference type="GeneID" id="100756822"/>
    <dbReference type="KEGG" id="cge:100756822"/>
    <dbReference type="CTD" id="50834"/>
    <dbReference type="OrthoDB" id="8876749at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033038">
        <property type="term" value="F:bitter taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15016">
        <property type="entry name" value="7tm_TAS2R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000055">
        <property type="entry name" value="Taste receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007960">
        <property type="entry name" value="TAS2R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394:SF149">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05296">
        <property type="entry name" value="TAS2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3 13" id="KW-0919">Taste</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027255800.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34017" checksum="DA2FBBA98D74EEB9" modified="2023-06-28" version="1">MVQGHIFFFLVVVVQLFTGVLANGLIMVVNAIDLIIRRKMAPLDLLLSCLATTRIILLMFVFLAQLDIFCLEKYSLFANSIAFVFFINELSLWLATWLSVFYCAKIATISHPLFLWIKMRISRLVPWLILGSVLHATTIALIHGRETSTIPKQVFTHYFSENSTQVKQIHVLPLSIFILGLTLPSLIFIVAVLLLIFSLCNHCWQMRTMAGTREPSRHGHISAMLSILSFFILYFTHYMVALVVSTQVFHLGSISFLFCTLVIGIYPSLHSVILILGNPKLKQNAKMFIVHCKCCHCVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JEP5</accession>
    <name>A0A9J7JEP5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ttc39b</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the TTC39 family.</text>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of cholesterol storage"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of cholesterol efflux"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00006400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027255999.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="69476" checksum="C352A24EED7E641C" modified="2023-06-28" version="1">MALVGSRVELDADEDIFEDALETISISPSDMATSSFPFVPCDTKRASRQLGASAVGSSSAKVDLKSGLEECAEALNLFLSNKFKDALELLRPWAKESMYHALGYSTIVVLQAIMTFEQQDIQNGISAMKDALQTCQKYRKKCTVVESFSSLLSRGSLEQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHVIQKNKHEQHFFYEFEGGVKLGTGAFNLMLSLLPARIIRLLEFIGFSGNRDLGLLQLREGASGSSMRSPLCCLTILAFHTYISLILGTGEVNVVEAESLLAPFLQQFPNGSLILFYHARIELLKGNVEKAQETFRKCIAVQEEWKQFHHLCYWELMWIFIYQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEDVATTNENVVALFRQVDGLKQRIAGKSLPTEKFAVRKARRYSPSSGAPGKLVLPALEMMYVWNGFSIVAQRKDLSESLLVTVEKAEAALQNQNFADSVDDECLVKLLKGCCLKNLQRPLQAELCFNHILESEKLLKYDHYLVPFTLFELAFLYKSQGEIDKAIKALETARNNYKDYSLESRLHFRIQAALHLWKKPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JJC5</accession>
    <name>A0A9J7JJC5_CRIGR</name>
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        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100763258</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263307.1">
        <property type="nucleotide sequence ID" value="XM_027407506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JJC5"/>
    <dbReference type="GeneID" id="100763258"/>
    <dbReference type="KEGG" id="cge:100763258"/>
    <dbReference type="OrthoDB" id="6144443at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15951">
        <property type="entry name" value="7tmA_OR52R_52L-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF156">
        <property type="entry name" value="OLFACTORY RECEPTOR 52R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027263307.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35258" checksum="24A1F5DC28F7E602" modified="2023-06-28" version="1">MLASRNSSSHSTFFILLGIPGLENYQFWVAFPFCVMYIVAVTGNIIILHIIRIDHTLHEPMYLFLAMLATTDLIMSSSTQPKMLAILWFHDHKIEYHACLIQVFFIHAFSSVESGVLMAMALDRYVAICFPLQHSSILTTSVVIKLGAAVMVRGLLWVSPFCFMISRMPFCPNKVIPQSYCEHMAVLKLVCADTRVNRGYGLFVAFSVVGFDIIVISVSYVMILKAVLRLPPGEARLKAFGTCASHIGVILALYIPALFTFLTHRFGHHVPRVVHIMFANVYLLVPPMLNPIIYGVRTKQIRDRVIQGCCGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JL41</accession>
    <name>A0A9J7JL41_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100765762</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276708.1">
        <property type="nucleotide sequence ID" value="XM_027420907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JL41"/>
    <dbReference type="GeneID" id="100765762"/>
    <dbReference type="KEGG" id="cge:100765762"/>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276708.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33938" checksum="DCCB659B51560DCF" modified="2023-06-28" version="1">MSNVTEFILLGLTQDPDVQKFLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSITDGLYSSSIVPKMIYDLLSEESSISFNGCMTQLFAEHVFAGAEIILLIFMAYDRYVAICKPLHYLTIMNRPMCISLVVAAGIVGLVHGMIQTAFIAQLPFCGPNTINHFICDLIPLLELACTDTHTLGPLIAANSGSMCLLIFCMLMVSYVVILFSLRKHSSEGRHKALSTCISHVTVVVLFFVPCSYLYVRPVMTFPIDKIVSVFYTLVTPLLNPLIYTLRNEEVKKVIKKLLGQKRSNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JSI9</accession>
    <name>A0A9J7JSI9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PR domain-containing protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Prdm11</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May be involved in transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027278245.1">
        <property type="nucleotide sequence ID" value="XM_027422444.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JSI9"/>
    <dbReference type="GeneID" id="100761907"/>
    <dbReference type="KEGG" id="cge:100761907"/>
    <dbReference type="CTD" id="56981"/>
    <dbReference type="OrthoDB" id="9930943at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19195">
        <property type="entry name" value="PR-SET_PRDM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000014">
        <property type="entry name" value="PR domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044405">
        <property type="entry name" value="PRDM11_PR/SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057456">
        <property type="entry name" value="Znf_C17orf113"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF11">
        <property type="entry name" value="PR_SET DOMAIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25431">
        <property type="entry name" value="zf-C17orf113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="115"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027278245.1"/>
        </source>
    </evidence>
    <sequence length="1177" mass="134348" checksum="658D0373BD29B338" modified="2023-06-28" version="1">MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRPEPSSMEVEPKKLKGKRDLIVTKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKEAGGESDVRCINEVVPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHSMSQETIHRNLTRGEKRLQREKAEQALDNPEDIRCPSQFPVLKQGRSPYKRSFDEGDIHPQAKKKKIDLIFKDVLEASLESSNVEARQLALSTSLVIRKVPKYQDDDYGQSAAALTQGIQNICRTQGEGNWKVPQRVAKELGPLEDEEEEPASFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPILPPQVLELPEFSDPAASESMVSGPAIMEDDDQEVDSADESVSNDVMTATDESTKMSSATGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEMCRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVVDQYMNEGDCQILIHHIARALREDLVERIRQSPCLSIILDGQSDDLLADTVAVYVQYTSSDGPPATEFLSLQELGFSSTESYLQALDRAFTGLGIRLQDEKPTVGLGVDGANITASLRASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYSPRLMCELRSTASTLCEETEFLGDIRAIRWIIGEQNVLNALIKDYLEVVAHLKDVSSQTQRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYIFQGEYLLVSQVDNKIEEAIQEISRLADSPGEYLQEFEENFRESFNGIAVKNLRVAEAKFQSIREKICQKTQVILAQRFDSRSRVFVKACQVFDLAAWPRNSEELLSFGKEDMVQIFDHLEAIPTFSRDVCREGVDPRGSLLMEWRDLKADYYTKNGFKDLISHICKYKQRFPLLNKIIQVLKVLPTSTACCEKGRSALQRVRKNHRSRLTLEQLSDLLTIAVNGPPIANFDAKRALDSWFEEKSGNSYTLSAEVLSRMSALEQKPMLQAVDHGSEFYPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JSP7</accession>
    <name>A0A9J7JSP7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Epididymal-specific lipocalin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100759474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007651395.1">
        <property type="nucleotide sequence ID" value="XM_007653205.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278530.1">
        <property type="nucleotide sequence ID" value="XM_027422729.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JSP7"/>
    <dbReference type="GeneID" id="100759474"/>
    <dbReference type="KEGG" id="cge:100759474"/>
    <dbReference type="OrthoDB" id="9048943at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002971">
        <property type="entry name" value="Maj_urinary"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF28">
        <property type="entry name" value="EPIDIDYMAL-SPECIFIC LIPOCALIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01221">
        <property type="entry name" value="MAJORURINARY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039892059" evidence="6">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027278530.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21192" checksum="95E37069B679B446" modified="2023-06-28" version="1">MVVLPVLGLVLSLAAAQFNQDVIVQRNYNMARISRNWYTICMASDNMTRIEENGDLRLFMRNIHLLKNGSLKFDFLFMVQGECVAVAMVCEKTEKNGEFTVAYEGENKVLLSETDYRTYVIFYMENIKNGTKTRVLALYGNPLPLDRSYLKRFVNICQKYGLDSQKIINLTRKDNCYDIPQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JTP5</accession>
    <name>A0A9J7JTP5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nicalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Ncln</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO.</text>
    </comment>
    <comment type="function">
        <text evidence="11">May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO1 and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003506490.1">
        <property type="nucleotide sequence ID" value="XM_003506442.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275021.1">
        <property type="nucleotide sequence ID" value="XM_027419220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JTP5"/>
    <dbReference type="GeneID" id="100761580"/>
    <dbReference type="KEGG" id="cge:100761580"/>
    <dbReference type="CTD" id="56926"/>
    <dbReference type="OrthoDB" id="5913609at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160064">
        <property type="term" value="C:multi-pass translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160063">
        <property type="term" value="P:multi-pass transmembrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03882">
        <property type="entry name" value="M28_nicalin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000021">
        <property type="entry name" value="Nicalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011018">
        <property type="entry name" value="Nicalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="13">
        <location>
            <begin position="217"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027275021.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="62875" checksum="6D865C1C4C956281" modified="2023-06-28" version="1">MLEEAGEVLENVLKASCLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQPYGTRNAVLNTEARTVDADVLSRRCVLMRLLDFSYEHYQKALRQSAGAVVIILPRAMAAVPQDVVRQFMEIEPEMLAMETVVPVYFAVEDEALLSIYEQTQAASASQGSASAAEVLLHTATANGFQMVTSGAQSQAVSDWLITSVEGRLTGLGGEDLPTIVIVAHYDAFGVAPWLSLGADSNGSGISVLLELARLFSRLYTYKRTHAAYNLLFFASGGGKFNYQGTKRWLEDSLDHTDSSLLQDNVAFVLCLDTVGRGSHLRLHVSKPPREGTLQHAFLRELETVAAHQFPDVSFSMVHKKINLADDVLAWEHERFAIRRLPAFTLSHLESHRAGPRSSIMDVRSRVDSKTLTRNTRIIAEALTRVIYNLTEKGTPPDMPVFTEQMQVQQEQLDSVMDWLTNQPRAAQLLDKDGTFLSTLEHFLSRYLKDVRQHHVKADKRDPEFVFYDQLKQVMNAYRVKPAIFDLLLAVCIGAYLGLAYTAVQHFHVLYKTVQRLLLKAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUP7</accession>
    <name>A0A9J7JUP7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Otud6b</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_035295860.1">
        <property type="nucleotide sequence ID" value="XM_035439969.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313160.1">
        <property type="nucleotide sequence ID" value="XM_035457269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JUP7"/>
    <dbReference type="GeneID" id="100768059"/>
    <dbReference type="CTD" id="51633"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000003">
        <property type="entry name" value="OTU domain-containing protein 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF21">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="147"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035295860.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37809" checksum="4E381161466E338D" modified="2023-06-28" version="1">MEEALVEELDDEEQLVRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEREMEQKHREELEQLKLTLKESKIDSVAVNISDLVLENQPPRISKAQKRREKKAALEKEREERIAEAEIENLSGARHVESEKLAQILAARELEIKQIPSDGHCMYGALEDQLREQNCALTVAALRKQTAEYMQSHSEDFLPFLTNPNTGNMYTPEEFGKYCDDIVNTAAWGGQLELRALSHILQTPIEILQADAPPIVVGEEYPKNPLILVYMRHAYGLGEHYNSVTRVSIAAATATSSCHQTPAVLTFFCELHTSNSPGRFQAFITRLGQLRHPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JWV5</accession>
    <name>A0A9J7JWV5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Scpep1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_027282087.1">
        <property type="nucleotide sequence ID" value="XM_027426286.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JWV5"/>
    <dbReference type="GeneID" id="100760556"/>
    <dbReference type="KEGG" id="cge:100760556"/>
    <dbReference type="CTD" id="59342"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039960763" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027282087.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51254" checksum="B7AD7328B2BA4ACC" modified="2023-06-28" version="1">MDLAWRVCPVPLWLLLQSLLLGLSAGAAVDWPAQEGKEAWDYVTVRKDAHMFWWLYYATNPCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDTHLKPRNTTWLQSASLLFVDNPVGTGFSYVNTTDAYAKDLDTVASDMMVLLKSFFDCHKEFQTVPFYIFSESYGGKMAAGISLELHKAVQQGNIKCNFSGVALGDSWISPVDSVLSWGPYLYSMSLLDDKGLAEVSNIAEQVLDAINKGFYKEATQLWGKAETIIEKNTDGVNFYNILTKSTPETSMESSLEFLRSPLVRLCQRHVRNLQRDTLSQLMNGPIRKKLKIIPEDCSWGGQSSYVFISMEGDFMKPVIHIVDELLEAGINVIVYNGQLDLIVDTMGQEAWLRKLKWPYLSKFNQLKWKALYSNPKSSETSAFVKSYENLAFYWILRAGHMVPADQGEMALKMMRLVTHQESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K0Y8</accession>
    <name>A0A9J7K0Y8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Ap1s2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds to MUC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027288527.1">
        <property type="nucleotide sequence ID" value="XM_027432726.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K0Y8"/>
    <dbReference type="GeneID" id="100768456"/>
    <dbReference type="CTD" id="8905"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000009">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027288527.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19208" checksum="ACA03303ADD4388A" modified="2023-06-28" version="1">MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEKKQTMYHSKSFIGYKRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K1G4</accession>
    <name>A0A9J7K1G4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Semaphorin-4F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Semaphorin-W</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">Sema4f</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Probable cell surface receptor that regulates oligodendroglial precursor cell migration. Might also regulate differentiation of oligodendroglial precursor cells. Has growth cone collapse activity against retinal ganglion-cell axons.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts (via PDZ-binding motif) with DLG4/SAP90 (via PDZ domain 2); this interaction may promote translocation of DLG4/SAP90 to the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304939.1">
        <property type="nucleotide sequence ID" value="XM_035449048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K1G4"/>
    <dbReference type="GeneID" id="100759257"/>
    <dbReference type="KEGG" id="cge:100759257"/>
    <dbReference type="CTD" id="10505"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11261">
        <property type="entry name" value="Sema_4F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000351">
        <property type="entry name" value="semaphorin-4F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000010">
        <property type="entry name" value="semaphorin-4F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047085">
        <property type="entry name" value="Sem4F_Sema_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045791">
        <property type="entry name" value="Sema4F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF72">
        <property type="entry name" value="SEMAPHORIN-4F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19428">
        <property type="entry name" value="Sema4F_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 27" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039949127" description="Semaphorin-4F" evidence="27">
        <location>
            <begin position="26"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="28">
        <location>
            <begin position="224"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="879"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00063149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_035304939.1"/>
        </source>
    </evidence>
    <sequence length="953" mass="103154" checksum="57CB5879ECA95392" modified="2023-06-28" version="1">MGSLATLFLWGRRLVLLPLTDPADGDAALSAASSGRKTEYYPPAEFPLLERTAPQTVTSAVPTGIAFSGTSGTSGSSSSETPRTPAILPGSSLGPLFLFSKPHGEHPVGYDWVWKNASYGGHRALCALGRSSVRTRFRINKAELSRGDPRGAEARAVAVLIRGCWTRPTRHQAEPEMLTRAERPRPGPRPPPASPFPVPRSVLLLLLAMLSAPVCGRVPRSVPRTSLPISEADSYLTRFAAPQTYNYSALLVDPASHTLYVGARNSIFALTLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFIQILAIANASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDWIRTETLSSWLNAPAFVAAMVLTPAEWGDEDGDDEIFFFFTETSRVLNSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGQASGVLQDMTELRPQPRAGTPIFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECITNNMKLQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHIHRAVRIGAQLSVLEDLALFPEPQPVESMKLYRGWLLVGSNTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCPKEPGEHPVVFEVPVATKGHVVLPCSPSSAWASCVWHQPGGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAARVVAAYSLVWGSQGGSSNRAHTVVGAGLVGFFLGVLAASLTLLLIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGFPPPFLLDSCSSPAHIRLTGAPLATCDETSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3A6</accession>
    <name>A0A9J7K3A6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC118238328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035295844.1">
        <property type="nucleotide sequence ID" value="XM_035439953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3A6"/>
    <dbReference type="GeneID" id="118238328"/>
    <dbReference type="KEGG" id="cge:118238328"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000092">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF161">
        <property type="entry name" value="UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039921380" description="glucuronosyltransferase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035295844.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32521" checksum="58DEC507AB7B8C6E" modified="2023-06-28" version="1">MAPAGSPVSFPLCVYLLLASGFSQAGRLLVVPMDGSHWFTMQMVVEKLIHKGHEVVVVVPEASWQLGKSLNLTVKTYSTSHTLEDLNHILKAASAAQWINPEHSTLSLIRGFGKVFFDFIASHCRSLFNDKKLVEYLKQSSFDAVFLDPFELCGLTVAKYLSLPSVFFSRYFLCHYVEEGAQCPGPLSYVPRLFSKFTDTMTFMERVSNLVYYMEERVFCHYIFKTAVEIASEVLQTPVTMDDLFYQVSIWLFRTDFVLDFPKPVMPNMVFIGGINCQQRKPLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3I9</accession>
    <name>A0A9J7K3I9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113839011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027290282.1">
        <property type="nucleotide sequence ID" value="XM_027434481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3I9"/>
    <dbReference type="GeneID" id="113839011"/>
    <dbReference type="KEGG" id="cge:113839011"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027290282.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21228" checksum="2FBE48574A96A651" modified="2023-06-28" version="1">MTQYKIVVVGADGVGKSALTIQLLQNHFVDVYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAMNNTKSFEAIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTIDTSQAQDLAGSYGIPFIETSAKTRQGVDDAFYTLVQEIRNHKEKVSNDGKKKKKMSKTKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3V2</accession>
    <name>A0A9J7K3V2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-specific adenosine deaminase 1</fullName>
            <ecNumber evidence="8">3.5.4.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-specific adenosine-37 deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">Adat1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16">17A/GY</strain>
            <tissue evidence="15 16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically deaminates adenosine-37 to inosine in tRNA-Ala.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA(Ala) + H2O + H(+) = inosine(37) in tRNA(Ala) + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50968"/>
            <dbReference type="Rhea" id="RHEA-COMP:12855"/>
            <dbReference type="Rhea" id="RHEA-COMP:12856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ADAT1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.34" evidence="8"/>
    <dbReference type="RefSeq" id="XP_016835047.1">
        <property type="nucleotide sequence ID" value="XM_016979558.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016835048.1">
        <property type="nucleotide sequence ID" value="XM_016979559.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298575.1">
        <property type="nucleotide sequence ID" value="XM_035442684.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298576.1">
        <property type="nucleotide sequence ID" value="XM_035442685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3V2"/>
    <dbReference type="GeneID" id="100767121"/>
    <dbReference type="CTD" id="23536"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A to I editase" evidence="13">
        <location>
            <begin position="63"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035298575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035298576.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="55314" checksum="08E7AB919698B417" modified="2023-06-28" version="1">MWTADEIAQLCYAHYSVKLPKQGKPEPNREWTLLAAVVKIQSPANQVCDATDKEVPVTKEVVSMGTGTKCIGQSKMRKSGDILNDSHAEIIARRSFQRYLLHQLHLAAVLKEDSVFVPGTQRGLWKLRPDLSFVFFSSHTPCGDASIIPMLEFEEQPCCPVIRNWAINSPVEKSNNLEDSKNKRDCEDPGSSVAKKMRLGTPAMTLSNSIAHHETQESGSIKPDVSSSNLTKEELDTANGIAPGSFKVVDVYRTGAKCVPGETGDLRKPGAAYHQVGLLRVKPGRGDRTCSMSCSDKMARWNVLGCQGALLMHFLEEPIYLSAVVIGKCPYSQEAMRRALTGRCQEVLALPRGFGVPELKIEQSSLLFEQSRCAVQMQRADIPGRLVPCGAAISWSAVPEHPLDVTANGFPQGITKKEIGSPRARSRISKVELFRSFQKLLSSITEDKQPDSVRGPGLCMPLPTFRVGLPTAVKRSWKTSSWTCPEAGFPGDSNYNSSLVDNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4G4</accession>
    <name>A0A9J7K4G4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LOW QUALITY PROTEIN: membrane-spanning 4-domains subfamily A member 6D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100764510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035293387.1">
        <property type="nucleotide sequence ID" value="XM_035437496.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297196.1">
        <property type="nucleotide sequence ID" value="XM_035441305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764510"/>
    <dbReference type="KEGG" id="cge:100764510"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035297196.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13055" checksum="D7F0550CF10197C7" modified="2023-06-28" version="1">MIPQLVTNETVTVISTNGTNFPQTDKPQPSHQKQDSLKKHLRAGVKVMAAIQIMCGGMVLCLGIILASAPKTPHFTPVYSLLLKSGYPFVGSLFVSRDLCGARWXRTEEGAITXLSFCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K532</accession>
    <name>A0A9J7K532_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRAME family member 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC113838758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRAME family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309722.1">
        <property type="nucleotide sequence ID" value="XM_035453831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K532"/>
    <dbReference type="GeneID" id="113838758"/>
    <dbReference type="KEGG" id="cge:113838758"/>
    <dbReference type="OrthoDB" id="9628575at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
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    <dbReference type="InterPro" id="IPR026271">
        <property type="entry name" value="PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF3">
        <property type="entry name" value="PRAME LIKE 17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038286">
        <property type="entry name" value="PRAME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035309722.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48449" checksum="56F667CACE40E319" modified="2023-06-28" version="1">MVAAWPFSYLPVGALMETPNVELLQAVLGGVDILQAQKVRPRRWKLRVLDLRNMTQDFWDVWPSRKNWYCSTETESQEQVGNKLRRDVKVVTDLSLRFYLKEHQTCLLQWAQQRKDSVQLCCVKMIIFAFPVEIINEVLDIFLPDDIEELELFTNQVLIFLGHIAPHFGHMTKLRKFCLTHTFLQTDMVVNTLADIEEMCALQFLSEFSKLNSLKHLSMEGIYFSHLPLQQLLSCLKTPLESLSINLCYLTHSDLINLSQCQRLCQLKHLNLSNVVFSKSGVTHLRVLLENTADSLQTLELANCRMGDSELSALLPALSQCSQITTANFYDNDISTAILKKLVQSMANLSNLTAEFYPAPLECYDPLGSVHVEEFSQLCIELQNIVFAKRQPKTIVFGTGICLECRRRCVYNTEIRLCQCWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K8Y1</accession>
    <name>A0A9J7K8Y1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Lmtk3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035302343.1">
        <property type="nucleotide sequence ID" value="XM_035446452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103164350"/>
    <dbReference type="KEGG" id="cge:103164350"/>
    <dbReference type="CTD" id="114783"/>
    <dbReference type="OrthoDB" id="5973359at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000347">
        <property type="entry name" value="Apoptosis associated tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000275">
        <property type="entry name" value="Apoptosis associated tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE LMTK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE LMTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039899535" description="non-specific serine/threonine protein kinase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="133"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="413"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="544"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="680"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="865"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="927"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="986"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1038"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1326"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="771"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="994"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1084"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1200"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1245"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1273"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1329"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1348"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035302343.1"/>
        </source>
    </evidence>
    <sequence length="1424" mass="150822" checksum="1159D40BFD12D1CD" modified="2023-06-28" version="1">MPAPGALILLAAVSASGCLASPAHPDGFALSRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVRFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPVPAPQPAHSDISTPLGLSRQHLSYLQEIGSGWFGKVILGEVFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSFVLVDQSRESNVWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPSHSAPRPGTLSSQFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPSWQPASAPPAPHTNPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPGPQASQAPSEVPQLVSETWASPLFPAPRPFQAQSSGSGGFLLSGWDPEGRGAGETLAGDPAEVLGEQGTAPWAEEEEEESSPGEDSSSLGGGPSHRGPLPCPLCSREGPCSCLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAERGSLADLPLVPPPSAPSEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRAPTEPAASPXPPSALASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGAQEKSTFVVQVSTEQLLMSLREDVTKNLLGDKGSTPGETGPRKAGRSPANREKGPGPNRDLTSLGSRKIVPSWNLPVNGVTVLENGKLGAPDTKEKVAENGLESPERGEKALVNGEPMSPEAEEKVLANGVLMSPKIEEKVAENGVLKLPRNMERPPETGPRRAPGPWEKMPETGGQAPEILLDQAPAPCEAALPQNGLETVPGQLGPVPKSGNPEPGTEWRVHETGGALRAPGAGKLDLGSGGRAQGGAGMVPAGGPASGVDAKAGWVDSSRPLPPPPQPLGTKQRRPEPVPLKSRPEVAPEEEPEVPDNRLGGDTALSVDEDPPKLERKGPEMPRLFLDLGPPQGNSEQIKAKLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAVGAGAPGPAEEDGEDEDEDEEDEEAAGSRGPGRTLEAPVPVVVSSVDADTARPLRGLLKSPRAADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQGTPEGDTDPSTPPAPPTPPHPATPGDGFPNNDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPTRAPDARPAGPVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KA14</accession>
    <name>A0A9J7KA14_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LOW QUALITY PROTEIN: serpin A11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Serpina11</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301807.1">
        <property type="nucleotide sequence ID" value="XM_035445916.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316304.1">
        <property type="nucleotide sequence ID" value="XM_035460413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765747"/>
    <dbReference type="KEGG" id="cge:100765747"/>
    <dbReference type="CTD" id="256394"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000003">
        <property type="entry name" value="alpha-1-antitrypsin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000001">
        <property type="entry name" value="Serine protease inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.310.10:FF:000001">
        <property type="entry name" value="Serpin family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.310.10">
        <property type="entry name" value="Serpins superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF154">
        <property type="entry name" value="SERPIN A11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039936743" evidence="7">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="8">
        <location>
            <begin position="59"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035301807.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51432" checksum="6B52BBDA4DE1B9C3" modified="2023-06-28" version="1">MGPFWLWLLVTKVLLPVHCQPFSAHAEKSLGVPQAASHQLLEPAPAYHKVTPTITNFALRLYKQLAEKVPGNVLFSPVSLSSIVALLSLGAPADTQAQMLESLGFNLTETPAPDIHRGFQSLLHTLDLPSSKLELKVRHSLFLDRQLKPQQHFLDSAKELYGALAFSANFTDAGATGQQINDLVRKQTYGQVVGCLPEFGHDTFMVLLNYIFFKAKWKHPFDRYQTRKQESFFLDRRTVLRIPMMQQKEMHRFLYDQEASCTVLQIEYSGTALLLLVLPDPGKMQQVEASLKPETLRRWGQLFLPRKAQAGGGGDDGFHWGSVSKWTXDTVGELSLKHLXMNQMWGLLDLHLPRFSISASYNLEEILPLIGLGNMFGVEADLSGIMGQLNKTVSRVSHKAVVDMNEKGTEAAAASGLLSQPLPLNMTSASQAHFNRPFLLLLWEVTTQSLLFLGKVVNPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KDD8</accession>
    <name>A0A9J7KDD8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC113833395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC113833395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307348.1">
        <property type="nucleotide sequence ID" value="XM_035451457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KDD8"/>
    <dbReference type="GeneID" id="113833395"/>
    <dbReference type="KEGG" id="cge:113833395"/>
    <dbReference type="OrthoDB" id="9893755at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09273">
        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039464">
        <property type="entry name" value="Gag-pol_Znf-H3C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002079">
        <property type="entry name" value="Gag_p12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF38">
        <property type="entry name" value="LRRGT00076-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01141">
        <property type="entry name" value="Gag_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16721">
        <property type="entry name" value="zf-H3C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="241"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="697"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035307348.1"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122551" checksum="AD55717E7827BA82" modified="2023-06-28" version="1">MTGRVSSLWGLHSPECHATSPIDPFCPCRDAGLEGPVRGFADSWVWVFFHERTSPGVFHLGARSGIETPAQGPPTHIWELPPHSSLYPTAVKDAKAEEKKTPEVLPPGENLLADLLTEEPPPYPALPPPPEAEAAPAVSAETASAPPPDPSPMAHRLRGRREQPAPDSTALPLRTGPNGQPQYWPFSASDLYNWKNNNPSFSADPVRLTSLIESVLTTHQPTWDDCEQILQVLLTSEEKQRVLLEARKNVPGANGQPTQLPNEIDAACPLERPEWDFTTEAGRTHLRLYRQLLVAGLRGAGRRPTNLAQGATGGKQYHWTTNRQLQLATVLDLKDAFFCLRLHPTSQPIFAFEWQDADLGISGQLTWTRLPQGFKNSPTLFDEALHQDLAGFRVRYPALILLQYVDDILLAAKTKEECKEGTRALLQTLGSLGYRASAKKAQICQKQVTYLGYKIKDGRRWLTEARMRAILDIPTPQNPRQLREFLGTAGFCRLWIPGFAEMAAPLYPLTRPGVAFKWEEPQKKAFTNIKKALLESPALGLPDLAKPFELFIDEKGGYAKGVLTQKLGPWRRPTAYLSKKLDPVASGWPPCLRMIAAIALLVKDSYKLTLGQPLTIHAPHAVEAVIRQPPDRWLTNARMTHYQTMLLDKDRVHFGPLVTLNPATLLPLPGEPEAHNCLQVLAEAHGARPDLTDQPLPSPDHIWFTDGSSFLHQGKRRAGAAVTTENQVVWAQALPPGTSAQRAELIALTQALKLAEGKRLTVYTDSRYAFATAHIHGEIYRRRGLLTSEGKDIKNKEEILALLRALHLPSALSIIHCPGHQKGDSLEARGNRRADLAAREAALTTDTTSLLALEPTNDRPSPSWDYEQRDIQTLEKLGATKEPNGDWTYEGKTVIPYRVTKYLVTFLHKMTHLSSKKMRELLEREEEFNFLLGKNDILKQVTEQCDACARVNASRLKLPPGNRVRGYRPGTHWEIDFTEIKPAHLQALQLVQREIWKPLAQAYKDQRDHPTIPHSYQIGDTVWVRRHQAKNLEPHWKGPYIVLLTTPTALKVDGIAAWIHASHVKPARPTDSATTSEWTAHRTQNPLKIRLSRTPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KFI8</accession>
    <name>A0A9J7KFI8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IgE-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118239691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035308907.1">
        <property type="nucleotide sequence ID" value="XM_035453016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KFI8"/>
    <dbReference type="GeneID" id="118239691"/>
    <dbReference type="KEGG" id="cge:118239691"/>
    <dbReference type="OrthoDB" id="9630350at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045345">
        <property type="entry name" value="Gag_p24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050195">
        <property type="entry name" value="Primate_lentivir_Gag_pol-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008916">
        <property type="entry name" value="Retrov_capsid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40389">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40389:SF3">
        <property type="entry name" value="IGE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00607">
        <property type="entry name" value="Gag_p24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19317">
        <property type="entry name" value="Gag_p24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14787">
        <property type="entry name" value="zf-CCHC_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035308907.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38896" checksum="3D52A98D55D00F0D" modified="2023-06-28" version="1">MAFPVFENEGARIHAPVDYNQIKELAESVRKYGVNANFTTIQVERLANYAMTPTDWETTVKAVLPNMGQYMEWKALFYDAAQAQAKANVTAENENQRQWTFEMLTGQGPHALNQTNYIWGVYAQISAAAIKAWKALTKRDESGGHLTKIVQGPQEPFSDFVARMTEAASRIFGDAEQAMPLIEQLVFEQATQECRAAIAPRKSKGLQDWLKICRELGGPLTNAGLAAAILQTQRRRNTSACFNCGKTGHLKKDCRAPKRIREVELYRRCGKGYHRASECKSVRDIKGRLLPPREEPKVSQPKNGLRGPWSQGPQKYGNQFRKSNSEKEGTPEDTPEWTCVPPPTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G3GTH2</accession>
    <name>G3GTH2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Na(+)/H(+) exchange regulatory cofactor NHE-RF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Slc9a3r1</name>
        <name evidence="14" type="synonym">Nherf1</name>
        <name evidence="13" type="ORF">I79_000956</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Endomembrane system</location>
            <topology evidence="2 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000019">
        <property type="protein sequence ID" value="EGV92378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641362.1">
        <property type="nucleotide sequence ID" value="XM_007643172.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281535.1">
        <property type="nucleotide sequence ID" value="XM_027425734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GTH2"/>
    <dbReference type="SMR" id="G3GTH2"/>
    <dbReference type="IntAct" id="G3GTH2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="10029.G3GTH2"/>
    <dbReference type="PaxDb" id="10029-XP_007623627.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030347.1">
        <property type="protein sequence ID" value="ENSCGRP00001026101.1"/>
        <property type="gene ID" value="ENSCGRG00001023524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100689081"/>
    <dbReference type="KEGG" id="cge:100689081"/>
    <dbReference type="CTD" id="9368"/>
    <dbReference type="eggNOG" id="KOG3528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182849"/>
    <dbReference type="OMA" id="KHNMKCL"/>
    <dbReference type="OrthoDB" id="10007415at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031698">
        <property type="term" value="F:beta-2 adrenergic receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099103">
        <property type="term" value="F:channel activator activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0017081">
        <property type="term" value="F:chloride channel regulator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050780">
        <property type="term" value="F:dopamine receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070851">
        <property type="term" value="F:growth factor receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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    </dbReference>
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        <property type="term" value="F:PDZ domain binding"/>
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    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
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    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031799">
        <property type="term" value="F:type 2 metabotropic glutamate receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031800">
        <property type="term" value="F:type 3 metabotropic glutamate receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032782">
        <property type="term" value="P:bile acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090660">
        <property type="term" value="P:cerebrospinal fluid circulation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045198">
        <property type="term" value="P:establishment of epithelial cell apical/basal polarity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051683">
        <property type="term" value="P:establishment of Golgi localization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022612">
        <property type="term" value="P:gland morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034635">
        <property type="term" value="P:glutathione transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:maintenance of epithelial cell apical/basal polarity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030033">
        <property type="term" value="P:microvillus assembly"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010764">
        <property type="term" value="P:negative regulation of fibroblast migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0010642">
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    </dbReference>
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        <property type="term" value="P:phospholipase C-activating dopamine receptor signaling pathway"/>
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        <property type="term" value="P:regulation of renal phosphate excretion"/>
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        <property type="term" value="P:renal phosphate ion absorption"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Na(+)/H(+) exchange regulatory cofactor NHE-RF"/>
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        <property type="entry name" value="NHER"/>
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        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="149"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="13">
        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027281535.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38592" checksum="30F68A569E253F91" modified="2011-11-16" version="1">MSADAAAGEPLPRLCCLEKGPNGYGFHLHGEKGKVGQFIRLVEPGSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRIRGALNAVRLLVVDPETDEHLKKLGVPIREDLLRSQKSEQAEPPAAADAQATDQNEAEKSHLERRELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKAGGDEAKLLVVDKETDEFFKKCKVIPSQEHLDGPLPEPFTNGEIQKESSREALVEAASESPRPALVRSASSDTSEELNSQDSPKRQESTEPSSTSSSSDPILDFNISLAVAKERAHQKRSSKRAPQMDWSKKNELFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3GTU6</accession>
    <name>G3GTU6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA repair protein RAD51 homolog 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">R51H3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RAD51 homolog D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RAD51-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Rad51d</name>
        <name evidence="17" type="ORF">I79_001085</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts with BLM; required for stimulation of BLM activity by the BCDX2 subcomplex XRCC2:RAD51D.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000022">
        <property type="protein sequence ID" value="EGV94391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003495849.1">
        <property type="nucleotide sequence ID" value="XM_003495801.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282283.1">
        <property type="nucleotide sequence ID" value="XM_027426482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GTU6"/>
    <dbReference type="STRING" id="10029.G3GTU6"/>
    <dbReference type="PaxDb" id="10029-XP_007608658.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014442.1">
        <property type="protein sequence ID" value="ENSCGRP00001010221.1"/>
        <property type="gene ID" value="ENSCGRG00001012167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766176"/>
    <dbReference type="KEGG" id="cge:100766176"/>
    <dbReference type="CTD" id="5892"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRIHTFR"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19489">
        <property type="entry name" value="Rad51D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001042">
        <property type="entry name" value="DNA repair protein RAD51 homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047323">
        <property type="entry name" value="Rad51D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048943">
        <property type="entry name" value="RAD51D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21794">
        <property type="entry name" value="RAD51D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="16">
        <location>
            <begin position="78"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV94391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027282283.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35173" checksum="064B2E94C318AC5D" modified="2011-11-16" version="1">MGVLRVGLCPGLTEEIVQLLKGQRIKTVADLAAANLEEVAQKCGLSYKALVALRRVLLAQFSAFPLNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCVAANVAHSLQQNVLYVDSSGGMTASRLLQLLQARTQDEEKQAGALQRIQVVHVFDIFQMLDMLQDLRGSMAQQSTSSSGTVKVVIVDSVTAVIAPLLGGQQREGLALMMQLARELKILARDLAVAVVVTNHLTRDRDGRRFKPALGRSWSFVPSTRILLDVTKGAGTLGRGQRTVCLTKSPRQPTGLQEVIDIGTLGTEEQSPELPAKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3GVW8</accession>
    <name>G3GVW8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial genome maintenance exonuclease 1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14 15 16" type="primary">Mgme1</name>
        <name evidence="8" type="synonym">MGME1</name>
        <name evidence="10" type="ORF">I79_001872</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15 16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15 16">17A/GY</strain>
            <tissue evidence="14 15 16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MGME1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JH000044">
        <property type="protein sequence ID" value="EGV95405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648627.1">
        <property type="nucleotide sequence ID" value="XM_007650437.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648629.1">
        <property type="nucleotide sequence ID" value="XM_007650439.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277430.1">
        <property type="nucleotide sequence ID" value="XM_027421629.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277431.1">
        <property type="nucleotide sequence ID" value="XM_027421630.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277432.1">
        <property type="nucleotide sequence ID" value="XM_027421631.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297890.1">
        <property type="nucleotide sequence ID" value="XM_027442089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GVW8"/>
    <dbReference type="STRING" id="10029.G3GVW8"/>
    <dbReference type="PaxDb" id="10029-XP_007630516.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024535.1">
        <property type="protein sequence ID" value="ENSCGRP00001020291.1"/>
        <property type="gene ID" value="ENSCGRG00001019490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768303"/>
    <dbReference type="KEGG" id="cge:100768303"/>
    <dbReference type="CTD" id="92667"/>
    <dbReference type="eggNOG" id="ENOG502QVKE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003349"/>
    <dbReference type="OMA" id="DCVAKYQ"/>
    <dbReference type="OrthoDB" id="5777131at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000005">
        <property type="entry name" value="Mitochondrial genome maintenance exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03030">
        <property type="entry name" value="MGME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK endonuclease-like" evidence="9">
        <location>
            <begin position="189"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV95405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027277430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027277431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027277432.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38606" checksum="4BF250DCD53E8231" modified="2011-11-16" version="1">MKPFLTICRLLRSLNRFSTKPSPLASFSTSPCLCGQKKKNSYEAIDQKKYARLVRSVLSRGPVQTPESLFQEDNILYGPVSKHRAPEQQQQGRVPQNWFPIFNEERNVKPHTSASSGPLKIPLQKNVAPSVTRILQQTMTPEQCFFLERWKQRMVLELGEDGFAEYTKSIFLQGQQFHDALESILSLQENLKGTEEHLQCGYIKSVQHILKEISGVQALESAVQHEALKYVGLLDCVAEYQGKLCVIDWKTSEKPKPFIGDTYDNPLQVVAYMGAVNHDAHYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTEKQKNQSVPKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3GW05</accession>
    <name>G3GW05_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Cytochrome c oxidase assembly factor 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">LOC100756398</name>
        <name evidence="10" type="ORF">I79_001911</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for assembly of mitochondrial respiratory chain complex I and complex IV.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for assembly of mitochondrial respiratory chain complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with CHCHD4/MIA40 through transient intermolecular disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the hcp beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000045">
        <property type="protein sequence ID" value="EGV97944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003496556.1">
        <property type="nucleotide sequence ID" value="XM_003496508.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258219.1">
        <property type="nucleotide sequence ID" value="XM_027402418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GW05"/>
    <dbReference type="STRING" id="10029.G3GW05"/>
    <dbReference type="PaxDb" id="10029-XP_007611055.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030653.1">
        <property type="protein sequence ID" value="ENSCGRP00001026407.1"/>
        <property type="gene ID" value="ENSCGRG00001023745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756398"/>
    <dbReference type="KEGG" id="cge:100756398"/>
    <dbReference type="eggNOG" id="KOG4014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004835"/>
    <dbReference type="OMA" id="PGCINAG"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000401">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040239">
        <property type="entry name" value="HcpB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV97944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027258219.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25758" checksum="0A147563E0E6C773" modified="2011-11-16" version="1">MAGLVDFQDEEQVKSFLENMKVECHYQCYREKDPDGCYRLVDYLEGIQKNFDEAAKVLKFNCEDNGHSDSCYKLGAYYVTGKGGLTQDLKAASACFLMACEKPGKKSVESCHNVGLLAHDGQINEDGQPDLRKARDYYTRACDGNYAASCFNLSTMFLQGAPGFPKDMGLACKYSMKACDLGHVWACANASRMYKLGDGVDKDEAKAEMLKNRAQQLHKEQQKNVQPVTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3H0F5</accession>
    <name>G3H0F5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RNF182</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING finger protein 182</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase RNF182</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Rnf182</name>
        <name evidence="23" type="ORF">I79_003610</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 28">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with ATP6V0C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="JH000091">
        <property type="protein sequence ID" value="EGV92876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258784.1">
        <property type="nucleotide sequence ID" value="XM_027402983.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298830.1">
        <property type="nucleotide sequence ID" value="XM_035442939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H0F5"/>
    <dbReference type="STRING" id="10029.G3H0F5"/>
    <dbReference type="PaxDb" id="10029-XP_007626535.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013795.1">
        <property type="protein sequence ID" value="ENSCGRP00001009578.1"/>
        <property type="gene ID" value="ENSCGRG00001011666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766488"/>
    <dbReference type="KEGG" id="cge:100766488"/>
    <dbReference type="CTD" id="221687"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111020"/>
    <dbReference type="OMA" id="SWTVWNC"/>
    <dbReference type="OrthoDB" id="8936585at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16555">
        <property type="entry name" value="RING-HC_RNF182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000319">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042285">
        <property type="entry name" value="RNF182"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047986">
        <property type="entry name" value="RNF182_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46675">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46675:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV92876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_035298830.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27542" checksum="877B09DF3696C6E3" modified="2011-11-16" version="1">MASQPPEEPVETQVSDELECKICYNRYNLKQRKPKVLECCHRVCAKCLYKIIDFGDSPQGVIVCPFCRFETCLPDDEVSSLPDDNNILVNLTCGSKGKKCLPENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLTSTPVVEFYRPASFDSVTTVSHNWTVWNCTSLLFQTSIRVLVWLLGLLYFSSLPLGIYLLVSKKVTLGVVFVSLVPSSLVILMVYGFCQCVCHEFLDCMALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
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    <name>G3H2Z2_CRIGR</name>
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        <recommendedName>
            <fullName evidence="3">Sodium channel modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Scnm1</name>
        <name evidence="14" type="ORF">I79_004597</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000120">
        <property type="protein sequence ID" value="EGV94829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498715.1">
        <property type="nucleotide sequence ID" value="XM_003498667.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249374.1">
        <property type="nucleotide sequence ID" value="XM_027393573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H2Z2"/>
    <dbReference type="STRING" id="10029.G3H2Z2"/>
    <dbReference type="PaxDb" id="10029-XP_007624130.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007419.1">
        <property type="protein sequence ID" value="ENSCGRP00001004887.1"/>
        <property type="gene ID" value="ENSCGRG00001006323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769370"/>
    <dbReference type="KEGG" id="cge:100769370"/>
    <dbReference type="CTD" id="79005"/>
    <dbReference type="eggNOG" id="ENOG502QWNV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGKYACT"/>
    <dbReference type="OrthoDB" id="1924550at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033570">
        <property type="entry name" value="SCNM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031625">
        <property type="entry name" value="SCNM1_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031622">
        <property type="entry name" value="Znf-SCNM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32297">
        <property type="entry name" value="SODIUM CHANNEL MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32297:SF1">
        <property type="entry name" value="SODIUM CHANNEL MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15805">
        <property type="entry name" value="SCNM1_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15803">
        <property type="entry name" value="zf-SCNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="14 18" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Sodium channel modifier 1 zinc-finger" evidence="12">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium channel modifier 1 acidic C-terminal" evidence="13">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV94829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027249374.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25621" checksum="56119C45435361D4" modified="2011-11-16" version="1">MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQSGKKTEQKPRQQNELKTESKAEAPLLTQTRLITQSALHRAPHYSSCCRRKHRPEAPAPSVSSSPLPAPEVGLQSAKISREPETKAGSHAKESSDLLASAPISPTKRRVLNHYLTLRSSGWIPDGQGRWIKDENVEFDSDEEEPPDLPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3H899</accession>
    <name>G3H899_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5 6">IQ domain-containing protein F1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">Iqcf1</name>
        <name evidence="2" type="ORF">I79_006599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5 6">17A/GY</strain>
            <tissue evidence="5 6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000209">
        <property type="protein sequence ID" value="EGW08881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639271.1">
        <property type="nucleotide sequence ID" value="XM_007641081.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270215.1">
        <property type="nucleotide sequence ID" value="XM_027414414.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299813.1">
        <property type="nucleotide sequence ID" value="XM_035443922.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310414.1">
        <property type="nucleotide sequence ID" value="XM_035454523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H899"/>
    <dbReference type="STRING" id="10029.G3H899"/>
    <dbReference type="PaxDb" id="10029-XP_007617601.1"/>
    <dbReference type="GeneID" id="100766292"/>
    <dbReference type="KEGG" id="cge:100766292"/>
    <dbReference type="CTD" id="132141"/>
    <dbReference type="eggNOG" id="ENOG502SR3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H899"/>
    <dbReference type="OrthoDB" id="9803391at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000344">
        <property type="term" value="P:positive regulation of acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000014">
        <property type="entry name" value="IQ motif containing F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000015">
        <property type="entry name" value="IQ motif containing F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039887">
        <property type="entry name" value="IQCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21633:SF14">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21633">
        <property type="entry name" value="IQ MOTIF CONTAINING F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW08881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027270215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035299813.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16906" checksum="1FFEDC21EBBF00F9" modified="2011-11-16" version="1">MVSEKTSAVKIQAWWRGTLVRRALLHAALRAWIIQCWWRLILRKIMEKRRHSILDSFQQEQWAAVRLQSWVRMWHIRRRYRRVLKAVRIIQAHWRCHACSSRGIIKGHYRITASQMQLELEIFLGSGPCIVTECIPLPIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3HG87</accession>
    <name>G3HG87_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosylated lysosomal membrane protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lysosomal protein NCU-G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Glmp</name>
        <name evidence="15" type="ORF">I79_009608</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Lysosome membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
            <orientation evidence="10">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000344">
        <property type="protein sequence ID" value="EGW07058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502960.1">
        <property type="nucleotide sequence ID" value="XM_003502912.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248911.1">
        <property type="nucleotide sequence ID" value="XM_027393110.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HG87"/>
    <dbReference type="STRING" id="10029.G3HG87"/>
    <dbReference type="GlyGen" id="G3HG87">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007635256.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008313.1">
        <property type="protein sequence ID" value="ENSCGRP00001005403.1"/>
        <property type="gene ID" value="ENSCGRG00001007094.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755558"/>
    <dbReference type="KEGG" id="cge:100755558"/>
    <dbReference type="CTD" id="112770"/>
    <dbReference type="eggNOG" id="ENOG502QSBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005131"/>
    <dbReference type="OMA" id="TLHYLWD"/>
    <dbReference type="OrthoDB" id="6264340at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981:SF1">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15065">
        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732176" description="Glycosylated lysosomal membrane protein" evidence="14">
        <location>
            <begin position="28"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGW07058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027248911.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="43422" checksum="192B7A259F935A04" modified="2011-11-16" version="1">MCRCWGPYWGWVPCAPTPWLLLSLVCAAPFGLLGEETRQISMKVISSWPNPQNLLHIRAVGTNSTLHYVWSTLGPPAVVLVATNTTQSALSVNWSLLMSPDPYGGLMVLPKDSIQFSSALVFTRLLEFDSTKVSKGATQPSGKPYPPYSLAEFSWNNITNSLDLATLSAIFQGHPVDEPTGAFANGSLAFKVQAFSGSGRSAQPPRLLHTADSCQVEVSLDGASPRGNHSVFGLEVATVGTGPDCPSVKELHSIDDEYAPAVFQVNQLLWGSSPSGFMQWRPVAFSQKQRNRESAVPCQASSLHPTLAYSLPSSPVVQAFFGSQNLCAFNLTFGAPTGPGYWDQHYLSWSMLLGMGFPPVDALSPLVLGIMAVALGTPGLMLLGGGLFLLLRHKQYSEYQSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3HH13</accession>
    <name>G3HH13_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19 23">ATP-sensitive inward rectifier potassium channel 8</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="20">Potassium inwardly-rectifying channel, subfamily J, member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Kcnj8</name>
        <name evidence="19" type="ORF">I79_009908</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
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            <strain evidence="21">CHO K1 cell line</strain>
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    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="22" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="22">17A/GY</strain>
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    <reference evidence="22" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="22">17A/GY</strain>
        </source>
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                <consortium name="RefSeq"/>
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            <strain evidence="23">17A/GY</strain>
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        <reaction evidence="12">
            <text>K(+)(in) = K(+)(out)</text>
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        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="14">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGW00566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035304295.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47968" checksum="A897F25E293F942D" modified="2011-11-16" version="1">MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSAMEKSGLESTVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLVNQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRSNSIRRNNSSLMVPKVQFMTPEGNQCPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3HI03</accession>
    <name>G3HI03_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">U4/U6 small nuclear ribonucleoprotein Prp4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">U4/U6 snRNP 60 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD splicing factor Prp4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Prpf4</name>
        <name evidence="16" type="ORF">I79_010265</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Interacts directly with PRPF18, PPIH and PRPF3. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Interacts with ERCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000394">
        <property type="protein sequence ID" value="EGW06661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003503510.1">
        <property type="nucleotide sequence ID" value="XM_003503462.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256128.1">
        <property type="nucleotide sequence ID" value="XM_027400327.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HI03"/>
    <dbReference type="STRING" id="10029.G3HI03"/>
    <dbReference type="PaxDb" id="10029-XP_007631819.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021004.1">
        <property type="protein sequence ID" value="ENSCGRP00001016760.1"/>
        <property type="gene ID" value="ENSCGRG00001016992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753511"/>
    <dbReference type="KEGG" id="cge:100753511"/>
    <dbReference type="CTD" id="9128"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156006"/>
    <dbReference type="OMA" id="LNEPICY"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071001">
        <property type="term" value="C:U4/U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000147">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000356">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000113">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF5">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="16 20" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="15">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="268"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="360"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW06661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027256128.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="58340" checksum="FB767E76D591CC8F" modified="2011-11-16" version="1">MASSRASSTATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3HM30</accession>
    <name>G3HM30_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytoplasmic 60S subunit biogenesis factor ZNF622</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Zinc finger protein 622</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Znf622</name>
        <name evidence="17" type="ORF">I79_011776</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homo- and heterodimer. Associates with pre-60S ribosomal particles. Interacts with MELK and MYBL2. Interacts with DNAJC21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000501">
        <property type="protein sequence ID" value="EGW02207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504730.1">
        <property type="nucleotide sequence ID" value="XM_003504682.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255846.1">
        <property type="nucleotide sequence ID" value="XM_027400045.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HM30"/>
    <dbReference type="STRING" id="10029.G3HM30"/>
    <dbReference type="GlyGen" id="G3HM30">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007623607.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031978.1">
        <property type="protein sequence ID" value="ENSCGRP00001027730.1"/>
        <property type="gene ID" value="ENSCGRG00001024661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766017"/>
    <dbReference type="KEGG" id="cge:100766017"/>
    <dbReference type="CTD" id="90441"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008631">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000915">
        <property type="entry name" value="Zinc finger protein 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="138"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW02207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027255846.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53949" checksum="E52891BA4D0C641B" modified="2011-11-16" version="1">MATYTCITCRVAFRDAEMQRAHYKTDWHRYNLRRKVAGMAPVTAEGFQERVRAQRAVAEEEEASKGTATYCTVCSKKFATFNAYDNHLRSRRHVELEKKAVQAVSRQVEMLNEKNLEKGLGADGLDKDAMNAAIQQAIKAQPSTSPRKAPSVPTAAAPRAEGAIAGAGRRGAQEPRDPTEKPPRLQWFEQQAKKLAKQQGEESEQEDEEEDEEDWEDIDSDDGMECENSGVEDQDAEDADAGESPPLGAIPITDCLFCSHHSSSLMKNVAHMTKIHSFFIPDIEYLSDLKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMSDKSHCKLFTDGDAALEFADFYDFRSSYPDYKEGQDPNEIEQLSSDKTLECDDETMELILPSGARVGHRSLMRYYKQRFGLPRAVTVARNQKAVGRVLQQYRALGWTGSTGAALMRERDMQYVQRMKSKWMLKTGMKNNTTKQMHFRAQVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3HMQ0</accession>
    <name>G3HMQ0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="12">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Fkbp9</name>
        <name evidence="16" type="ORF">I79_012022</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
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        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
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            <strain evidence="19">17A/GY</strain>
        </source>
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    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">17A/GY</strain>
        </source>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="11">PPIases accelerate the folding of proteins during protein synthesis.</text>
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    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
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            <end position="24"/>
        </location>
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<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
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                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
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                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
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    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">17A/GY</strain>
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    </reference>
    <reference evidence="13 14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14">17A/GY</strain>
            <tissue evidence="13 14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000613">
        <property type="protein sequence ID" value="EGW08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007644492.1">
        <property type="nucleotide sequence ID" value="XM_007646302.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249652.1">
        <property type="nucleotide sequence ID" value="XM_027393851.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249653.1">
        <property type="nucleotide sequence ID" value="XM_027393852.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HQI5"/>
    <dbReference type="STRING" id="10029.G3HQI5"/>
    <dbReference type="GlyGen" id="G3HQI5">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007616397.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000803.1">
        <property type="protein sequence ID" value="ENSCGRP00001000779.1"/>
        <property type="gene ID" value="ENSCGRG00001000594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760604"/>
    <dbReference type="KEGG" id="cge:100760604"/>
    <dbReference type="CTD" id="10745"/>
    <dbReference type="eggNOG" id="ENOG502QQGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011648"/>
    <dbReference type="OMA" id="KMWQTRE"/>
    <dbReference type="OrthoDB" id="10066656at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039775">
        <property type="entry name" value="PHTF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021980">
        <property type="entry name" value="PHTF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680:SF8">
        <property type="entry name" value="PROTEIN PHTF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680">
        <property type="entry name" value="PUTATIVE HOMEODOMAIN TRANSCRIPTION FACTOR PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12129">
        <property type="entry name" value="PHTF1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="PHTF1/2 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027249652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027249653.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="86926" checksum="E02045B9E4F331AE" modified="2011-11-16" version="1">MASNERDAISWYQKKIGAYDQQIWEKSIEQTQIKGFKNKPKKMGHIKSDLIDVDLIRGSTFAKAKPEIPWTSLTRKGLVRVVFFPLFSSWWIQVTSLRIFVWLLLLYLMQVTAIVLYLMMPIVNVSEVLGPLCLMLLMGTVHCQIVSTQITKPSGNNGNRRRRKLRKTVNGDGSRDNGNNSSDKVRAVETLQSAPSVGGFWGTLFGNRIKRVKLVSNKGTETDNDSGCLHPIIKKRQGRPEIRMWQAREKAKVSDGEKCHREAYRHLGNGISDDLSSEEDGDARTQMILLRRSVEGASSDNGCEFKNRKSVFSRHLNSQVKKATTRWCHIVRDSDSLAESEFESTAFSQGSRSGVSAGSRSLNLSRRDSESTRHDSETEDMLWDDLLHGPECRSSVTSDSEGTHVNTLHSGTKRDPKEDVFQQNHLFWLQNSSPASERVSAIIWEGNECKKMDMSVLEISGIIMSRVNEYQQGVGYQMLGNAVTIGLAFFPFLYRLFREKSLDQLKSISAEEVLTLFCGAPPVTPVVVLSIINFFERLCLTWMFFFMMCVAERTYKQRFLFAKLFSHITSARKARKYEIPHFRLKKVENIKIWLSLRSYLKRRGPQRSVDVVVSSVFLLTLSIAFICCAQVLQGHKTFLNDVYNWEFLIWETALLLFLLRLASLGSETNKKYSNVSILLTEQINLYLKMEKKPNKKEQLTLVNNVLKLSTKLLKELDTPFRLYGLTMNPLIYNITRVVILSAVSGVISDLLGFNIRLWKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>G3HWE9</accession>
    <name>G3HWE9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">Tuba4a</name>
        <name evidence="19" type="ORF">I79_015306</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23">17A/GY</strain>
            <tissue evidence="22 23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000831">
        <property type="protein sequence ID" value="EGW11865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007646377.1">
        <property type="nucleotide sequence ID" value="XM_007648187.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253084.1">
        <property type="nucleotide sequence ID" value="XM_027397283.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253085.1">
        <property type="nucleotide sequence ID" value="XM_027397284.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027295975.1">
        <property type="nucleotide sequence ID" value="XM_027440174.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HWE9"/>
    <dbReference type="SMR" id="G3HWE9"/>
    <dbReference type="STRING" id="10029.G3HWE9"/>
    <dbReference type="PaxDb" id="10029-XP_007614241.1"/>
    <dbReference type="GeneID" id="100767686"/>
    <dbReference type="CTD" id="7277"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HWE9"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 16" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0944">Nitration</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="17">
        <location>
            <begin position="34"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="18">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGW11865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027253084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027253085.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48329" checksum="0448FC0BE3F4872A" modified="2011-11-16" version="1">MGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGKHVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLDRIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGIDSYEDEDEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3HXV5</accession>
    <name>G3HXV5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar and coiled-body phosphoprotein 1 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nucleolar phosphoprotein p130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Nolc1</name>
        <name evidence="3" type="ORF">I79_015870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000895">
        <property type="protein sequence ID" value="EGV98247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007646862.1">
        <property type="nucleotide sequence ID" value="XM_007648672.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262944.1">
        <property type="nucleotide sequence ID" value="XM_027407143.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HXV5"/>
    <dbReference type="STRING" id="10029.G3HXV5"/>
    <dbReference type="PaxDb" id="10029-XP_007637892.1"/>
    <dbReference type="GeneID" id="100773818"/>
    <dbReference type="KEGG" id="cge:100773818"/>
    <dbReference type="CTD" id="9221"/>
    <dbReference type="eggNOG" id="KOG2992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HXV5"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="624"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV98247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027262944.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="73456" checksum="5149BAC45631B8AD" modified="2011-11-16" version="1">MADTGLRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSTKAPKRKLQSNGPVTKKAKKETSSSDSSEDSSEEEEKAPGLPAKKAAVPAKRTSLPQHTGKAVAKASESSSSEESSDEEEEEDNKKKKPVQQKAVKPQAKAVRAPPKKAESSESESDSSSEDEAPQTTKLKTAAAAKAQPKAAAKPGTPARAQPKVANGKAASSSSSSSSSSDDSEEEEEKPTAPPKKMQTIPKKQVVAKAPVKVAATPTQKSSSSEESSSEEEEQKKPTKKKPGPYSSVPPPSVSLPKKSLGTQSPKKAAVQKQPAGSSGDSSDESDSSSEEEEKKAPAKAVLSKTPAKPAPAKPAPAKKKESSSDSSDSDSSEDEAPAKPVSTPKNPVSKAAVTPKPSAAKTAVTPKQPVGSGQKPQTRKADSSSSEEESSSSEEETAKKTVTTPKPKVTAKAAPSLPAKQAPQAGDSSSDSDSSSSDEEEKTPKPPAKTKAVGGRTPSKPASVKKAAAAQSSSSSESSSDEDEKPKGKGTAKPQASKANGTPASQNGKAGKESEEDEEEEETKMAVSKPGKKQKRNETAEEAGTPQAKKVKLQTPNTFPKRKKAEKRASSPFRRVREEEIEVDARVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSVKFDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3HY22</accession>
    <name>G3HY22_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein GUCD1 isoform X3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein C22orf13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Gucd1</name>
        <name evidence="1" type="ORF">I79_015921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000899">
        <property type="protein sequence ID" value="EGW12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250008.1">
        <property type="nucleotide sequence ID" value="XM_027394207.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HY22"/>
    <dbReference type="STRING" id="10029.G3HY22"/>
    <dbReference type="PaxDb" id="10029-XP_007619984.1"/>
    <dbReference type="GeneID" id="100767981"/>
    <dbReference type="CTD" id="83606"/>
    <dbReference type="eggNOG" id="KOG4621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HY22"/>
    <dbReference type="OMA" id="VQDIQKH"/>
    <dbReference type="OrthoDB" id="206796at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGW12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027250008.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22940" checksum="56E82697801C90A7" modified="2011-11-16" version="1">MVLRYLGQLDDGEFQNALQELQLTRSIWTIDLAYLMRHFGVRHRFCTQTLGVDKGYKNQSFYRKHFDTEETRVNQLFAQAKACKVRVEKCTVSVQDIQAHLAQGHVAIVLVNSGVLHCDLCSSPVKYCCFTPSGHRCFCRTPDYQGHFIVLRGYNRATGCIFYNNPAYADRMCSTSISNFEEARTSYGTDEDILFVYLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3I6A4</accession>
    <name>G3I6A4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial fission regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12 13 14 15 16" type="primary">Mtfr1l</name>
        <name evidence="8" type="ORF">I79_019016</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13 14">17A/GY</strain>
            <tissue evidence="12 13 14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MTFR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001349">
        <property type="protein sequence ID" value="EGW10731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255450.1">
        <property type="nucleotide sequence ID" value="XM_027399649.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255451.1">
        <property type="nucleotide sequence ID" value="XM_027399650.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255452.1">
        <property type="nucleotide sequence ID" value="XM_027399651.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255455.1">
        <property type="nucleotide sequence ID" value="XM_027399654.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295416.1">
        <property type="nucleotide sequence ID" value="XM_035439525.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317223.1">
        <property type="nucleotide sequence ID" value="XM_035461332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I6A4"/>
    <dbReference type="STRING" id="10029.G3I6A4"/>
    <dbReference type="PaxDb" id="10029-XP_007621890.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014079.1">
        <property type="protein sequence ID" value="ENSCGRP00001009860.1"/>
        <property type="gene ID" value="ENSCGRG00001011875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761781"/>
    <dbReference type="KEGG" id="cge:100761781"/>
    <dbReference type="CTD" id="56181"/>
    <dbReference type="eggNOG" id="ENOG502QRAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183215"/>
    <dbReference type="OrthoDB" id="9930891at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007972">
        <property type="entry name" value="Mtfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215:SF3">
        <property type="entry name" value="MITOCHONDRIAL FISSION REGULATOR 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215">
        <property type="entry name" value="PROTEIN OF UNKNOWN FUNCTION DUF729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05308">
        <property type="entry name" value="Mito_fiss_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW10731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027255450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027255451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027255452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027255455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035295416.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31744" checksum="F798D716CC8739B0" modified="2011-11-16" version="1">MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASTSLTPDFLSPGSSNVSSPLPCFGSSLHSTTSFVISDITEETEVEVPELPTIPLLCSASPECCKPEHKATCSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRKFALKEEDISRKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3I9T8</accession>
    <name>G3I9T8_CRIGR</name>
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        <recommendedName>
            <fullName evidence="19">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Rnf40</name>
        <name evidence="23" type="ORF">I79_020348</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="19"/>
    <dbReference type="EMBL" id="JH001646">
        <property type="protein sequence ID" value="EGW03635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511788.1">
        <property type="nucleotide sequence ID" value="XM_003511740.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260345.1">
        <property type="nucleotide sequence ID" value="XM_027404544.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I9T8"/>
    <dbReference type="STRING" id="10029.G3I9T8"/>
    <dbReference type="GlyGen" id="G3I9T8">
        <property type="glycosylation" value="2 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007609431.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003921.1">
        <property type="protein sequence ID" value="ENSCGRP00001002839.1"/>
        <property type="gene ID" value="ENSCGRG00001003244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750431"/>
    <dbReference type="KEGG" id="cge:100750431"/>
    <dbReference type="CTD" id="9810"/>
    <dbReference type="eggNOG" id="KOG0978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002866"/>
    <dbReference type="OMA" id="THIEIMT"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16815">
        <property type="entry name" value="RING-HC_RNF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000040">
        <property type="entry name" value="E3 ubiquitin protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058642">
        <property type="entry name" value="BRE1A/B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26052">
        <property type="entry name" value="BRE1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 19" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="15 19 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="948"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="519"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="230"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGW03635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027260345.1"/>
        </source>
    </evidence>
    <sequence length="1001" mass="113743" checksum="D2889029190D8F6A" modified="2011-11-16" version="1">MSGLSNKRAAGDGGSGPPEKKLNREEKTTTTLIEPIRLGGISSTEEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHERQRELSSGTEAPGCQEGLTRDGIPRTDPGTSDLREPLPMQFRTPLSEPALAFVVALGASSSEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRGDSEAPGEVARVRTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSSHCIPSLSHPDDSGLNALAPGKEDGGPGPGGTPDSKKEIAAVPGATPAASSVKKEELVSSEDDALALTPGNQGLPSRGREPEARPKRELREREGPVLGPPPVASALSRADREKAKVEEAKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRGRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3IAG0</accession>
    <name>G3IAG0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Xaa-Pro aminopeptidase 1</fullName>
            <ecNumber evidence="6">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytosolic aminopeptidase P</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Soluble aminopeptidase P</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">X-Pro aminopeptidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">X-prolyl aminopeptidase 1, soluble</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29 30" type="primary">Xpnpep1</name>
        <name evidence="26" type="ORF">I79_020582</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29 30" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29 30">17A/GY</strain>
            <tissue evidence="29 30">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Contributes to the degradation of bradykinin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="6"/>
    <dbReference type="EMBL" id="JH001703">
        <property type="protein sequence ID" value="EGW06752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262842.1">
        <property type="nucleotide sequence ID" value="XM_027407041.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262843.1">
        <property type="nucleotide sequence ID" value="XM_027407042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IAG0"/>
    <dbReference type="STRING" id="10029.G3IAG0"/>
    <dbReference type="PaxDb" id="10029-XP_007613849.1"/>
    <dbReference type="GeneID" id="100774913"/>
    <dbReference type="CTD" id="7511"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3IAG0"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000001">
        <property type="entry name" value="Putative xaa-Pro aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000004">
        <property type="entry name" value="xaa-Pro aminopeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000004">
        <property type="entry name" value="xaa-Pro aminopeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 26 29" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="24">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="23">
        <location>
            <begin position="328"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="25">
        <location>
            <begin position="557"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00079909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGW06752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027262842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027262843.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="69858" checksum="199C837729156662" modified="2011-11-16" version="1">MAPKVTSELLRQLRQAMRNVEYVAEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDNNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLVPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKEKVADLRLKMAERNIVWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIVGLEAIMLFIDGDRIDAPSVKQHLLLDLGLEAEYRIQVLPYKSILSELKTLCSDLSPREKVWVSDKASYAVSEAIPKEHRCCMPYTPICIAKAVKNLAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAIFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNSYHQTCRDVIGKELQIQGRQEALEWLLRETEPISKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3IBG3</accession>
    <name>G3IBG3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Ubiquitin-like modifier-activating enzyme 1</fullName>
            <ecNumber evidence="7">6.2.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Ubiquitin-activating enzyme E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 28 32 33" type="primary">Uba1</name>
        <name evidence="27" type="ORF">H671_xg19989</name>
        <name evidence="26" type="ORF">I79_020983</name>
    </gene>
    <organism evidence="26 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
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                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
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                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
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            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
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                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e96666." last="e96666.">
            <title>Characterization of Ubiquitin-Activating Enzyme Uba1 in the Nucleus by Its Mammalian Temperature-Sensitive Mutant.</title>
            <authorList>
                <person name="Sugaya K."/>
                <person name="Ishihara Y."/>
                <person name="Inoue S."/>
                <person name="Tsuji H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="6">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="7">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
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    </reference>
    <reference evidence="32 33" key="8">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32 33">17A/GY</strain>
            <tissue evidence="32 33">Liver</tissue>
        </source>
    </reference>
    <reference evidence="28" key="9">
        <citation type="submission" date="2025-05" db="UniProtKB">
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    <comment type="function">
        <text evidence="20">Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.</text>
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        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
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    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
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        <text evidence="6 22">Belongs to the ubiquitin-activating E1 family.</text>
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        <property type="protein sequence ID" value="ERE65731.1"/>
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        <property type="nucleotide sequence ID" value="XM_027432273.2"/>
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            <begin position="21"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="BAL52319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGW14761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ERE65731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027288074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_027288075.1"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117698" checksum="D252E8832DA25DC1" modified="2011-11-16" version="1">MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSQVPSVPTNGMAKNGSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNSPLEDQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMIQLNGCQPIEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLAASLAEPDFVMTDFAKFSRPGQLHIGFQALHQFCAQHNRPPRPRNEEDATELVALAQAMNARSPSAVQQDNLDEDLIRKLSYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEDKCLPRQSRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPFIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSASASVDDSRLEELKATLPSPDKLSGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3ICI2</accession>
    <name>G3ICI2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein uS14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">40S ribosomal protein S29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">LOC100757259</name>
        <name evidence="11" type="ORF">I79_021380</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001929">
        <property type="protein sequence ID" value="EGW01394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512635.1">
        <property type="nucleotide sequence ID" value="XM_003512587.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245130.1">
        <property type="nucleotide sequence ID" value="XM_027389329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ICI2"/>
    <dbReference type="STRING" id="10029.G3ICI2"/>
    <dbReference type="PaxDb" id="10029-XP_007636436.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013457.1">
        <property type="protein sequence ID" value="ENSCGRP00001009264.1"/>
        <property type="gene ID" value="ENSCGRG00001011398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757259"/>
    <dbReference type="KEGG" id="cge:100757259"/>
    <dbReference type="eggNOG" id="KOG3506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161931"/>
    <dbReference type="OMA" id="HQYANDI"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 11 15" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW01394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027245130.1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6498" checksum="87213C946FE92768" modified="2011-11-16" version="1">MGHQQLYWSHLRKFGQGPRSCGVCSNCHGLIRKYGLNMCCQCFRQYAKDIGFIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3IDS4</accession>
    <name>G3IDS4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras homolog family member C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11 15 16">Rho-related GTP-binding protein RhoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15 16" type="primary">Rhoc</name>
        <name evidence="11" type="ORF">I79_021857</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16">17A/GY</strain>
            <tissue evidence="15 16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002096">
        <property type="protein sequence ID" value="EGW05424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513012.1">
        <property type="nucleotide sequence ID" value="XM_003512964.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249671.1">
        <property type="nucleotide sequence ID" value="XM_027393870.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249672.1">
        <property type="nucleotide sequence ID" value="XM_027393871.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IDS4"/>
    <dbReference type="SMR" id="G3IDS4"/>
    <dbReference type="STRING" id="10029.G3IDS4"/>
    <dbReference type="PaxDb" id="10029-XP_007616390.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026938.1">
        <property type="protein sequence ID" value="ENSCGRP00001022693.1"/>
        <property type="gene ID" value="ENSCGRG00001021156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774717"/>
    <dbReference type="KEGG" id="cge:100774717"/>
    <dbReference type="CTD" id="389"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KNGFIMF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043297">
        <property type="term" value="P:apical junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031334">
        <property type="term" value="P:positive regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902766">
        <property type="term" value="P:skeletal muscle satellite cell migration"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AgBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044319">
        <property type="term" value="P:wound healing, spreading of cells"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AgBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW05424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027249671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027249672.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22006" checksum="A193DA581560F131" modified="2011-11-16" version="1">MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HUD5</accession>
    <name>A0A061HUD5_CRIGR</name>
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        <submittedName>
            <fullName evidence="8">Protein PPP4R3C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative SMEK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100773171</name>
        <name evidence="5" type="ORF">H671_xg20488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMEK family.</text>
    </comment>
    <dbReference type="EMBL" id="KE685714">
        <property type="protein sequence ID" value="ERE65140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510805.1">
        <property type="nucleotide sequence ID" value="XM_003510757.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288486.1">
        <property type="nucleotide sequence ID" value="XM_027432685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HUD5"/>
    <dbReference type="GeneID" id="100773171"/>
    <dbReference type="KEGG" id="cge:100773171"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF19">
        <property type="entry name" value="PROTEIN PPP4R3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="3">
        <location>
            <begin position="154"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ERE65140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027288486.1"/>
        </source>
    </evidence>
    <sequence length="793" mass="93225" checksum="C48551F46610FB47" modified="2014-09-03" version="1">MWPSETRSQIQPNERFHSVKVYFLNEDEQWEHLGSGQISTKYIGRLQGVCLLVHSESDGSLILECAIYADVPYRKPKMDLIIWTEPSNRTMAISFRNPDGCQDIWEDICQVQGKDPSVQMTQEFTDDLDVFQELPQIQNLCEMRTCENSTLEHIAHLFNFVQESPSFKERLAFLLENEDYIKKLLHIFHICEDQQNMEGLYFLYFIIRGILFLNNMRLYEIMFSDECIMDVLGCLEYDPILDQPYRHREFICVNAKFKEVMPIACSKLRQKIDQTYKMQYIHDILFPILSKFQDNHLSEFTTFIFYNKIEIVTMLQEDEMIFNEIFAQLKDNTLCHERQLELLFFFKEFCEYAKILNSQKKDEFLQTMIKLGLMSALKVSLHRQDYQTKEAAVDIFTYLIEYNPQIVRVYAMEEAQSSENDYDLINIIIKQILCDPDPESSYVLSLTALLRVLLDPERMQITVNACEKEGFMNFFYTHCVNNLAEPILAIPEQSDSDDNTANICPDNYQNAQLLAVVLELLSFCVKHHMTYMRNYILSNNLLSRILVLTSSKHTFLVLCAIRFMRQMVGVNDKLYNHYIITKNLFEPVVKAFIHNGKRNNMLNSAIIELFEFIREENIKSLVANIVKNFFTAFESIEYVQTFKGLKDKFEKENERQSEILRNLHKLLCQNRHCRHMKAMEVQGKEEMCSREITETILPMGRDFPKCFDVFLRIKDTNQNEVEQPERKASEAFDCYSSHFDASANRKSDPHCGRKVPLVDYPDDDDDDDDDDNEDHHDADEEEEPPHKIPKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I6V5</accession>
    <name>A0A061I6V5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Pou1f1</name>
        <name evidence="15" type="ORF">H671_4g12711</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with PITX1. Interacts with LHX3. Interacts with ELK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE675479">
        <property type="protein sequence ID" value="ERE75340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512879.1">
        <property type="nucleotide sequence ID" value="XM_003512831.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269124.1">
        <property type="nucleotide sequence ID" value="XM_027413323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I6V5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013566.1">
        <property type="protein sequence ID" value="ENSCGRP00001009361.1"/>
        <property type="gene ID" value="ENSCGRG00001011471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773365"/>
    <dbReference type="CTD" id="5449"/>
    <dbReference type="GeneTree" id="ENSGT00940000158913"/>
    <dbReference type="OMA" id="TSHAHGM"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021984">
        <property type="term" value="P:adenohypophysis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000150">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000007">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF84">
        <property type="entry name" value="NETRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="14">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="238"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE75340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027269124.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35704" checksum="77A964875E677FC9" modified="2014-09-03" version="1">MSCQSFTSADTFIPLNSDAPATLPLIMHHSAAECLPVSNHATNVMSTVPSILSLIQTPNCLHTYFSVTTMGNTATGLHYSVPSCHYGNQPSTYGVMAGGLTPCLYKFPDHTLSHGFPPLHQPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYSEKVGANERKRKRRTTISIAAKDALERHFGQQSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IB62</accession>
    <name>A0A061IB62_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box and WD-40 domain protein 17</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4 8">F-box/WD repeat-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">LOC100757422</name>
        <name evidence="4" type="ORF">H671_3g10045</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="KE672946">
        <property type="protein sequence ID" value="ERE78849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265724.1">
        <property type="nucleotide sequence ID" value="XM_027409923.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IB62"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012366.1">
        <property type="protein sequence ID" value="ENSCGRP00001008250.1"/>
        <property type="gene ID" value="ENSCGRG00001010558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757422"/>
    <dbReference type="KEGG" id="cge:100757422"/>
    <dbReference type="GeneTree" id="ENSGT00940000162955"/>
    <dbReference type="OrthoDB" id="63265at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF17">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ERE78849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027265724.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51782" checksum="848F43D76223088A" modified="2014-09-03" version="1">MAAQLGPHELLHVFSFLEARDLLLAAQVNKVWNEVSMTKELWRQLCLRRWASCGAFPVVLGTQTWRQYYFCRSELEFRVESGRPRDFISKAISGHAGKIDQLAYVSPHEYRFDEMARSVVCTVSSDCTVRAWDLHQGTEIWSSPVQPAPLVSLVAYPLLQLVVTVDTQGLIIGWKADTGSEWASFCLPTSCSSMEACGHPEGPFLMVACADGNLYTLTVPQLQVVSKVATFPRTSVSLTCSPDQQWVSVLAQGSDVGPKVFFTQPLLHPLEDELPVSTTLPVRLSSRACWAPDEASRLMVMHRDDSGVHLVITTFSLKANKSRDRVSILAQQLASFPLPGTVTPHLMQGHGSQVILLASRSELVLFTIQGLQLVAFRDHQRPITSMWVDPNRVVTSSLDLSLRVYVWDKKKTCPVLRSCYQLLGGSHRWASGFTHVKSDSMSIAGIEARSNGTSILRSYCFKVQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HAR1</accession>
    <name>A0A3L7HAR1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox protein Nkx-2.5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Homeobox protein NK-2 homolog E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">LOC113836654</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027280983.1">
        <property type="nucleotide sequence ID" value="XM_027425182.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HAR1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032101.1">
        <property type="protein sequence ID" value="ENSCGRP00001027853.1"/>
        <property type="gene ID" value="ENSCGRG00001024735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113836654"/>
    <dbReference type="KEGG" id="cge:113836654"/>
    <dbReference type="GeneTree" id="ENSGT00940000158996"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990664">
        <property type="term" value="C:Nkx-2.5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007512">
        <property type="term" value="P:adult heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003278">
        <property type="term" value="P:apoptotic process involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003228">
        <property type="term" value="P:atrial cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060413">
        <property type="term" value="P:atrial septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060928">
        <property type="term" value="P:atrioventricular node cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060929">
        <property type="term" value="P:atrioventricular node cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003166">
        <property type="term" value="P:bundle of His development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060038">
        <property type="term" value="P:cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003211">
        <property type="term" value="P:cardiac ventricle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060971">
        <property type="term" value="P:embryonic heart tube left/right pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060347">
        <property type="term" value="P:heart trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010667">
        <property type="term" value="P:negative regulation of cardiac muscle cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904036">
        <property type="term" value="P:negative regulation of epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010832">
        <property type="term" value="P:negative regulation of myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003148">
        <property type="term" value="P:outflow tract septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060037">
        <property type="term" value="P:pharyngeal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051891">
        <property type="term" value="P:positive regulation of cardioblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045823">
        <property type="term" value="P:positive regulation of heart contraction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010765">
        <property type="term" value="P:positive regulation of sodium ion transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003342">
        <property type="term" value="P:proepicardium development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003350">
        <property type="term" value="P:pulmonary myocardium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003168">
        <property type="term" value="P:Purkinje myocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903779">
        <property type="term" value="P:regulation of cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060043">
        <property type="term" value="P:regulation of cardiac muscle cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0055117">
        <property type="term" value="P:regulation of cardiac muscle contraction"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003221">
        <property type="term" value="P:right ventricular cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003285">
        <property type="term" value="P:septum secundum development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030878">
        <property type="term" value="P:thyroid gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055005">
        <property type="term" value="P:ventricular cardiac myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060412">
        <property type="term" value="P:ventricular septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003222">
        <property type="term" value="P:ventricular trabecula myocardium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000078">
        <property type="entry name" value="NK2 homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF28">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-2.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027280983.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34093" checksum="269B2BDFAE23B346" modified="2019-02-13" version="1">MFPSPALTPTPFSVKDILNLEQQQRSLAAGDLSARLEATLAPASCMLAAFKPEAYSGPEAAAPGLAELRAELGPAPSPPKCAPAFPAAPTFYPRAYGDPDPAKDPRVDKKELCALQKAVELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELLGPPPPPARRIAVPVLVRDGKPCLGDSAAYAPAYGVGLNAYGYNAYPYPGYGGAACSPGYSCAAYPAAPPAAQPAPTANGNFVNFGVGDLNAVQSPGMPQGNSGVSTLHGIRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HWN0</accession>
    <name>A0A3L7HWN0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Homeobox protein VENTX isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Msh homeobox 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Ventx</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Msh homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027265025.1">
        <property type="nucleotide sequence ID" value="XM_027409224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HWN0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000479.1">
        <property type="protein sequence ID" value="ENSCGRP00001000455.1"/>
        <property type="gene ID" value="ENSCGRG00001000375.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771818"/>
    <dbReference type="CTD" id="27287"/>
    <dbReference type="GeneTree" id="ENSGT00940000164040"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035035">
        <property type="term" value="F:histone acetyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035034">
        <property type="term" value="F:histone acetyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000271">
        <property type="entry name" value="Homeobox protein MSX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF9">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
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            <dbReference type="RefSeq" id="XP_027265025.1"/>
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    <sequence length="203" mass="21864" checksum="3D0BAE32C5534869" modified="2019-02-13" version="1">MARATLDMNAEGLGARGGGHVGHGPLPFSVESLLEAERVRGSEPGQLGEERPPGSSKPGAWPPPVTHTCPPRAPSPPPCTLRKHKNNRKPRTPFTTAQLLALERKFHQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKLAAKPLMPAFALPFPLGTQLHSSAAAFGGGAVPGILAGPVAAYGMYYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I7Z6</accession>
    <name>A0A3L7I7Z6_CRIGR</name>
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        <submittedName>
            <fullName evidence="17">Endoribonuclease ZC3H12A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Zinc finger CCCH type containing 12A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Zc3h12a</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003502297.1">
        <property type="nucleotide sequence ID" value="XM_003502249.5"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027399242.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I7Z6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018922.1">
        <property type="protein sequence ID" value="ENSCGRP00001014684.1"/>
        <property type="gene ID" value="ENSCGRG00001015497.1"/>
    </dbReference>
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    <dbReference type="OMA" id="DMWPYRS"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cellular response to chemokine"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to glucose starvation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cellular response to tumor necrosis factor"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:DNA damage response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044828">
        <property type="term" value="P:host-mediated suppression of viral genome replication"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010587">
        <property type="term" value="P:miRNA catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055118">
        <property type="term" value="P:negative regulation of cardiac muscle contraction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900016">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043031">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010656">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045019">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1901223">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:2000320">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032689">
        <property type="term" value="P:negative regulation of type II interferon production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
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    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:2000379">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="PIN_Zc3h12-like"/>
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        <property type="entry name" value="ZC3H12A isoform 1"/>
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        <property type="entry name" value="Rege-1_UBA-like"/>
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    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF10">
        <property type="entry name" value="ENDORIBONUCLEASE ZC3H12A"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rege-1 UBA-like" evidence="12">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RNase NYN" evidence="11">
        <location>
            <begin position="132"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Endoribonuclease Regnase 1/ZC3H12 C-terminal" evidence="13">
        <location>
            <begin position="542"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027255043.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="65725" checksum="682C8CB9C301A673" modified="2019-02-13" version="1">MSDPCRKKSVQEASPTMSLWELEDNHSCRGRPQPAQDPEAKEASAELQMKVDFFRKLGYSSSEIHSVLQKLGVQADTNTVLGELVKHGSASERECQASTDPCPQPPLVPRGGSTPKPSEPSLPEEDKDGSDLRPVVIDGSNVAMSHGNKEVFSCRGILLAVNWFLERGHTDITVFVPSWRKEQPRPDVPITDQHILRELEKKKILVFTPSRRVGGKRVVCYDDRFIVKLAYESDGVVVSNDTYRDLQGERQEWKRFIEERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKSLPSEHRKQPCPYGRKCTYGIKCRFFHPERPSRPQRSVADELRANALLSPPRTPVKDKSGPRSSPASQPSSVSPEAEQGSLDGKKLGARSSPGPHQEGSTQTFTAAGRSLPVSGGSFGPTEWFPHTVDSLPYTSQECLDSGIGSLESQMSELWGVRGGSPGESGPARGPYASYHTYGSELPAAPAYTPFRQPMGAGHFSVPGDYVPQPPTFPAREYWSEPYPLPSPTPVLQEPQRPSPGASRGPWDRVNKRAKERADVYTKLCGVFHPHLVEAVMGRFPQLLDPQQLAAEILSYKSQHLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IMK5</accession>
    <name>A0A3L7IMK5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Rab1a</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003498151.1">
        <property type="nucleotide sequence ID" value="XM_003498103.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243868.1">
        <property type="nucleotide sequence ID" value="XM_027388067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IMK5"/>
    <dbReference type="SMR" id="A0A3L7IMK5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015151.1">
        <property type="protein sequence ID" value="ENSCGRP00001010923.1"/>
        <property type="gene ID" value="ENSCGRG00001012691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752891"/>
    <dbReference type="KEGG" id="cge:100752891"/>
    <dbReference type="CTD" id="5861"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027243868.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22678" checksum="B2A8F4E3B0FB17D6" modified="2019-02-13" version="1">MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2L919</accession>
    <name>A0A8C2L919_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kazal-type serine peptidase inhibitor domain 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Kazal-type serine protease inhibitor domain-containing protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Kazald1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
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        <scope>IDENTIFICATION</scope>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035308195.1"/>
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    </evidence>
    <sequence length="224" mass="26165" checksum="1F17951C2EDC852E" modified="2022-01-19" version="1">MAAPTGPPSPMQSLREEAVCAICLDYFKDPVSIGCGHNFCRGCVTQLWGKEDERDRDRDREGPAPEDHVVREVLYHRHAEEELVFQTPPAPPWVGPSHRRSLRSTAAGSTWEDEEEDLNNNVQGLVHDLRIRVFPEEREEHHHNGHQYHHRGRYRHRRIFRRGPPHPPVRRQLYPDARVRSPPRPTPQVFSCPQCRRTFPSRSFRPNLQLANMVHIIRQICRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LDR0</accession>
    <name>A0A8C2LDR0_CRIGR</name>
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        <submittedName>
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        <submittedName>
            <fullName evidence="3">Acyl-Coenzyme A binding domain containing 7</fullName>
        </submittedName>
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        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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            <taxon>Cricetinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="6">17A/GY</strain>
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        </source>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSCGRP00001000406.1"/>
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        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027261307.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9981" checksum="216185C611EE8049" modified="2022-01-19" version="1">MSLQADFDQAAQDVRKLKSRPEDEELKELYGLYKQSIIGDINIACPAMLDLKGKAKWEAWSLQKGLSKEDAMSAYISKARELIEKYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LFK9</accession>
    <name>A0A8C2LFK9_CRIGR</name>
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        <submittedName>
            <fullName evidence="10">Dpy-19 like 4</fullName>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Dpy19l4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027259309.2">
        <property type="nucleotide sequence ID" value="XM_027403508.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LFK9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005018.1">
        <property type="protein sequence ID" value="ENSCGRP00001003472.1"/>
        <property type="gene ID" value="ENSCGRG00001004221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759810"/>
    <dbReference type="KEGG" id="cge:100759810"/>
    <dbReference type="CTD" id="286148"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20180">
        <property type="entry name" value="Dpy19L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047464">
        <property type="entry name" value="Dpy19L4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF2">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="201"/>
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    </feature>
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            <end position="331"/>
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            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
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        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LG53</accession>
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            <fullName evidence="12">Olfactory receptor</fullName>
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    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027247649.1">
        <property type="nucleotide sequence ID" value="XM_027391848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LG53"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003414.1">
        <property type="protein sequence ID" value="ENSCGRP00001002542.1"/>
        <property type="gene ID" value="ENSCGRG00001002850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768188"/>
    <dbReference type="KEGG" id="cge:100768188"/>
    <dbReference type="GeneTree" id="ENSGT01140000282532"/>
    <dbReference type="OrthoDB" id="9902777at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15912">
        <property type="entry name" value="7tmA_OR6C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000013">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF32">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027247649.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35491" checksum="B55846C1B57AFA7E" modified="2022-01-19" version="1">MKNHSVITEFVLLGISDDPELQVVIFIFLFIAYILSITGNLTIVILTLLDSRLKTPMYFFLRNFSFLEIIFTSVSIPRFLASIITQVKTISYNNCLAQLFFFISMGVSEFFLLTAMSYDRYVAICKPLHYTTIMNQRVCTLLVLTSWLAGFLTIFPPLMLVLKLDFCASNVIDHFSCDYFPILQLSCSDTKSLEMIGFYFAFVTLLFTLALVILSYICIISTILRFPSASQRKKAFSTCSSHMIVISISYGSCIFMYVKPSANERASLTKGVAVLNTSIAPMLNPFIYTLRNQQVKQAFKDLVHKVILYRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LND8</accession>
    <name>A0A8C2LND8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14 15" type="primary">Emc6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15">17A/GY</strain>
            <tissue evidence="14 15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282604.1">
        <property type="nucleotide sequence ID" value="XM_027426803.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282605.1">
        <property type="nucleotide sequence ID" value="XM_027426804.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LND8"/>
    <dbReference type="SMR" id="A0A8C2LND8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010779.1">
        <property type="protein sequence ID" value="ENSCGRP00001006828.1"/>
        <property type="gene ID" value="ENSCGRG00001009289.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103160389"/>
    <dbReference type="KEGG" id="cge:103160389"/>
    <dbReference type="CTD" id="83460"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903349">
        <property type="term" value="C:omegasome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027282604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027282605.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12017" checksum="5120B6E4CC12FD48" modified="2022-01-19" version="1">MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LQ35</accession>
    <name>A0A8C2LQ35_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15">Olfactory receptor 56B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">LOC113834889</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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    <sequence length="319" mass="35388" checksum="CA01199650CAADE5" modified="2022-01-19" version="1">MFQDLTSSNSSRFQVSEFILMGFPGIHSWQHWLSLPLALLYVLALIANILIITTIYQEESLHQPMYHFLGILAIVDMGLATTIMPKILAILWFNAKTISLPECFAQMYAIHSFIAMESGIFVCMAIDRYVAICRPLRYPSIVTESFVIKATLLMVLRNCGTPMSVPVLAAQRNYCSRNQIEHCLCSNLGVTSLSCDDRTVNSINQLVIAWAIMGGDLGLIMISYALILRAVLKLNSAEAASKALSTCTSHLILIFFFYTVIVVLSITHGSQMKVPLIPVLLNVLHNVIPPALNPMVYALKNKELKQGLNKVLKLEVKGG</sequence>
</entry>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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</entry>
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    <accession>A0A8C2LWC9</accession>
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        </submittedName>
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    </gene>
    <organism evidence="5 6">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8 9 10">17A/GY</strain>
            <tissue evidence="8 9 10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSCGRG00001009835.1"/>
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    <dbReference type="KEGG" id="cge:100773947"/>
    <dbReference type="CTD" id="54537"/>
    <dbReference type="GeneTree" id="ENSGT00390000003133"/>
    <dbReference type="OMA" id="TVHEDQW"/>
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        <property type="component" value="Unplaced"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="InterPro" id="IPR049507">
        <property type="entry name" value="SHLD2_OB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053944">
        <property type="entry name" value="SHLD2_OB2"/>
    </dbReference>
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        <property type="entry name" value="SHIELDIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14495:SF2">
        <property type="entry name" value="SHIELDIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OB_SHLD2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="423"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Shieldin complex subunit 2 second OB fold" evidence="4">
        <location>
            <begin position="588"/>
            <end position="669"/>
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    <feature type="domain" description="Shieldin complex subunit 2 C-terminal" evidence="2">
        <location>
            <begin position="726"/>
            <end position="889"/>
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            <begin position="190"/>
            <end position="231"/>
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            <end position="302"/>
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        <location>
            <begin position="391"/>
            <end position="413"/>
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    </feature>
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        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF22779"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LWE0</accession>
    <name>A0A8C2LWE0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113830629</name>
        <name evidence="16" type="synonym">LOC100761950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027421095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LWE0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014001.1">
        <property type="protein sequence ID" value="ENSCGRP00001009782.1"/>
        <property type="gene ID" value="ENSCGRG00001011826.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cge:100761950"/>
    <dbReference type="GeneTree" id="ENSGT00900000141017"/>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027276896.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35164" checksum="1E6AE561B5ED6891" modified="2022-01-19" version="1">MHNQSFVNEFILLGLSQNPQIEKISFVMFSLVYLATIVGNMMIVMTIVYSPALLGSPMYFFLAFLSFLDACVSSVVTPKMIADLVYEKKTISFECCMTQVFAVHFLTAVEVIILAAMAYDRYVAICKPLHYSFIMNRRLCGILVGVAWAGGFLHSIIQMSFTLQLPFCGPNVIDHFICDLFPLLKLACTDTHFFIILVFANSGSICIIIFSFLLVSYGIILFSLRGHSSEGRRKALSTCGSHVTVVVFFFVPCILIYARPTSAFSFEKNVFVFTDVMTPLLNPMVYTFRNKEMINAIRKMWRKLVVVSDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M0H3</accession>
    <name>A0A8C2M0H3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterogeneous nuclear ribonucleoprotein A1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Helix-destabilizing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">hnRNP core protein A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Hnrnpa1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SEPT6. Interacts with C9orf72. Interacts with KHDRBS1. Interacts with UBQLN2. Interacts with PPIA/CYPA.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007652254.1">
        <property type="nucleotide sequence ID" value="XM_007654064.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252576.1">
        <property type="nucleotide sequence ID" value="XM_027396775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M0H3"/>
    <dbReference type="SMR" id="A0A8C2M0H3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015750.1">
        <property type="protein sequence ID" value="ENSCGRP00001011518.1"/>
        <property type="gene ID" value="ENSCGRG00001013129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769923"/>
    <dbReference type="KEGG" id="cge:100769923"/>
    <dbReference type="CTD" id="3178"/>
    <dbReference type="GeneTree" id="ENSGT00950000183123"/>
    <dbReference type="OMA" id="AQFTKHF"/>
    <dbReference type="OrthoDB" id="6019873at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061752">
        <property type="term" value="F:telomeric repeat-containing RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903936">
        <property type="term" value="P:cellular response to sodium arsenite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051168">
        <property type="term" value="P:nuclear export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12761">
        <property type="entry name" value="RRM1_hnRNPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12582">
        <property type="entry name" value="RRM2_hnRNPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000048">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein a1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000429">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A1-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034516">
        <property type="entry name" value="hnRNPA1/3_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021662">
        <property type="entry name" value="HnRNPA1/A2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034845">
        <property type="entry name" value="hnRNPA1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF2">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11627">
        <property type="entry name" value="HnRNPA1_LC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027252576.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="38804" checksum="DFF83B613168380A" modified="2022-01-19" version="1">MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M650</accession>
    <name>A0A8C2M650_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Wnt3a</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282004.1">
        <property type="nucleotide sequence ID" value="XM_027426203.2"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M758</accession>
    <name>A0A8C2M758_CRIGR</name>
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        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13 16" type="primary">LOC100768298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027242281.1">
        <property type="nucleotide sequence ID" value="XM_027386480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M758"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018275.1">
        <property type="protein sequence ID" value="ENSCGRP00001014038.1"/>
        <property type="gene ID" value="ENSCGRG00001015029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768298"/>
    <dbReference type="KEGG" id="cge:100768298"/>
    <dbReference type="GeneTree" id="ENSGT00940000162873"/>
    <dbReference type="OrthoDB" id="6130476at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027242281.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34648" checksum="87BA832882B0388C" modified="2022-01-19" version="1">METENGTVVTEFILIGLTQSHAIQLLVFVLSLIFYIIILPGNVFIIITIMSDHGLSAPLYFFLGNLAFLDASYSFIVTPRMLVDIFSEKKVISYKDCITQLFFLHFFGGGEFLLLVVMAFDRYIAICRPLHYSTVMSPRACSVMLLAPWLGGFVHSIIQVVLILRLPFCGPNHVDNFFCDVPQVIKLACTDTFAVELLMIFNSGLLTLVCFLGLLTSYAVILCHVHRSASEGKNKAISTCTTHVIIIFLMFGPAIFIYTRPFTALSVDKVVSFFHTVIFPLLNPVIYTLRNQEVKTSMKRLFIQKIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MEY0</accession>
    <name>A0A8C2MEY0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA mismatch repair protein Mlh3 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">MutL homolog 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Mlh3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301050.1">
        <property type="nucleotide sequence ID" value="XM_035445159.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311981.1">
        <property type="nucleotide sequence ID" value="XM_035456090.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001022533.1">
        <property type="protein sequence ID" value="ENSCGRP00001018289.1"/>
        <property type="gene ID" value="ENSCGRG00001018094.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755089"/>
    <dbReference type="KEGG" id="cge:100755089"/>
    <dbReference type="CTD" id="27030"/>
    <dbReference type="GeneTree" id="ENSGT00800000124176"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005712">
        <property type="term" value="C:chiasma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007144">
        <property type="term" value="P:female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03486">
        <property type="entry name" value="MutL_Trans_MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein Mlh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000028">
        <property type="entry name" value="DNA mismatch repair protein Mlh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000031">
        <property type="entry name" value="DNA mismatch repair protein Mlh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.20:FF:000005">
        <property type="entry name" value="MutL homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="211"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="1184"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="974"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035301050.1"/>
        </source>
    </evidence>
    <sequence length="1447" mass="162365" checksum="92FB777E6765CCCB" modified="2022-01-19" version="1">MIKCLSDEVQAKLRSGLAIISLSQCVEELILNSIDAEAKCVAIRVNMETFQVQVIDNGFGMAGDDVEKVGNRYFTSKCNSIQDLENSKFYGFRGEALASIVDMASTVEILSKKNTTMKTFVKMFQNGKALNVCEADLTRPSVGTTVTVYNLFSQFPVRRKSMDPRLEFEKVRQRVEAISLMHPSISFSLRNDVSGAMVLQLPKTKDICSRFCQIYGLGKSQKLREIHFKYKEFEFSGYVSSEAHYNKNMQFLFVNRRLVLRTKLHKLIDFLLRKESIICRPKNGSASRHMNSSPRHRSASELHGIYVINVQCQFCDYDVCMEPAKTLIEFQNWDTLLICIQEGVKRFLKQEKLFVELSGEDIKEFNDDNDFSLLGATLQTHVSTHEMCEQSSFQEACNHILDSYEMFNLQSKTVKRIATIENTNPQNSGASEAIRKKTNDSSRHCEADGLGGSKMIEPSSPSKNSAHSESRVLQEAAQSGENEEHQKSFLEHRRASESPPGTSPKMFPNPIRTHHLFEKGKAELETQKISTAVNVMAADIPQYGGIQSPLEKCKEATKVGYQPLPFETTAFRVHDTQRKKEKGRKEPSSHGRVNVFSYGQVKLCSTGFITHVVQKEHTKSAEAEHSFKSYVRPGPVSAQETFGNRAHHAVETLGNNDFTSTLNKEPAHLLHKKLRRTNASYGTEDNPAAADENLTLFQESGTGSHRDCFLPDTSSFPWYRYASNKKTDKMMCSSKHVVHRKLSLRSQVGSLEKFKRQYGKVNSSLDTEGDSNTEVRTHRDARVETGILLKDKDHLDTSDGGESTAVDPSDSHDACQPASHIPFSETFPFSKEDYLGQMPHLRESPITLTELSHCRRKPSNVEKSAESLASKLSRLKGSEKEMQTMEMTDYISELPDSGSSWTDSSRAARSDLHACELLKNKHEKIESGMLLIPDPATHDNSSHDSAIHSKNIMDGTERRETPLLLLPCNDSEISKDSDVLTRSSEQHTGSPDPPHRMTMSQVEDSTASQGGTCSQNEESKARSCSTNEDSNSYCMGWQQHFDVTLGRMVYINRTTGLSTFVAPTEDIKTACTKDLTTVAVDVLLGNGVQYRCHPFRSDLILPFLPRAQEERTMLRQNDRDAVGAAAVSESLQSLFSEWNNPVFARYPEVAVDVSSGRAESLAVKIHNVLYPYRFTKEMVHSMQVLQQVDNKFIACLMSTKMEENGKAGGNLLVLVDQHAAHERVRLEQLISDSYEKQPPQSSGRKKLLSSMIIPPLAITVPKEQRRLLWSYHKHLEDLGLELIFPDASDSLILVGKVPLCFVEREASELRRGRCTVTKSIVEEFIREQVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDCLSLEESYRLIEALSLCQLPFQCAHGRPSMLPLADLDHLEQEKQVKPNIAKLRKMARAWHLFGKAEGRDNKAEPVTVHASCEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJV4</accession>
    <name>A0A8C2MJV4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ADP-ribosylation factor-binding protein GGA3 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Golgi associated, gamma adaptin ear containing, ARF binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Gga3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GGA protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007641214.3">
        <property type="nucleotide sequence ID" value="XM_007643024.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281485.1">
        <property type="nucleotide sequence ID" value="XM_027425684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MJV4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024059.1">
        <property type="protein sequence ID" value="ENSCGRP00001019815.1"/>
        <property type="gene ID" value="ENSCGRG00001019142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756491"/>
    <dbReference type="KEGG" id="cge:100756491"/>
    <dbReference type="CTD" id="23163"/>
    <dbReference type="GeneTree" id="ENSGT00940000157333"/>
    <dbReference type="OrthoDB" id="447025at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902430">
        <property type="term" value="P:negative regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14240">
        <property type="entry name" value="GAT_GGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17008">
        <property type="entry name" value="VHS_GGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1230:FF:000001">
        <property type="entry name" value="ADP-ribosylation factor-binding protein GGA1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000023">
        <property type="entry name" value="ADP-ribosylation factor-binding protein GGA3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000011">
        <property type="entry name" value="ADP-ribosylation factor-binding protein GGA3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044111">
        <property type="entry name" value="GAT_GGA3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027422">
        <property type="entry name" value="GGA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046996">
        <property type="entry name" value="VHS_GGA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905:SF3">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="VHS" evidence="12">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="14">
        <location>
            <begin position="171"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="13">
        <location>
            <begin position="602"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027281485.1"/>
        </source>
    </evidence>
    <sequence length="731" mass="79275" checksum="2494660EF0EC7769" modified="2022-01-19" version="1">MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEAVQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLFSWTLALPEEAKIKDAYQMLKRQGIVHSDPPIPMDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHYNQEYSSEADKELMKELFDRCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIVEGQTINGEVTTSTMPDSEGNDHCSSQGTLIDLAELDTPCSSSPVLAPAPAPPTSGIPILPPPPQTSAPPRSRSSSQAEVPQGPDSTSSGLSLLDEELLCLGLTDPAPTASKESAGNSQWHLFQSEPSSDLDFFNPRPVSAACGPSDGSLLPPPVSTSSTSQAPLPAPFPAPVVPASVPAPSTGSFMFSSGPAPASIPKAEPAAPKYHSSALGDSTSNRLDALDQLLEEAKVTSGLVKPVSCFSTGATASPLLPASTPARPLLPFSKGPGSPLFQSPAFQSQGSPLRAPELSLASVHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVRSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGEQLSTELGEVDQFPPVEQWGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MKA1</accession>
    <name>A0A8C2MKA1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Threonine aspartase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14 15" type="primary">Tasp1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15">17A/GY</strain>
            <tissue evidence="14 15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Intramolecular proteolysis generates 2 subunits, alpha and beta, which reassemble through a non-covalent association to form the fully active enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007643066.1">
        <property type="nucleotide sequence ID" value="XM_007644876.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643067.1">
        <property type="nucleotide sequence ID" value="XM_007644877.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277463.1">
        <property type="nucleotide sequence ID" value="XM_027421662.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277464.1">
        <property type="nucleotide sequence ID" value="XM_027421663.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MKA1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024008.1">
        <property type="protein sequence ID" value="ENSCGRP00001019764.1"/>
        <property type="gene ID" value="ENSCGRG00001019111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769290"/>
    <dbReference type="KEGG" id="cge:100769290"/>
    <dbReference type="CTD" id="55617"/>
    <dbReference type="GeneTree" id="ENSGT00950000183045"/>
    <dbReference type="OMA" id="RLWCAFT"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000002">
        <property type="entry name" value="Taspase, threonine aspartase, 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="9">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027277463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027277464.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="44305" checksum="71BF07692B1327FC" modified="2022-01-19" version="1">MTMEKGMSSGEGLPSRSPQASAAKVTVKESETRQPCEEKRGGFVLVHAGAGYHSESKAKEYKHVCKRACQKAIEKLQAGALATDAVTAALVELEDSPFTNAGMGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVANRLLCEGQKGKLSAGRIPPCFLVGEGAYRWAVDHGIPSCPPSIMTTRFSLAAFKRNKRKLELAERVETDFIQLKKRRQSSAKENDSGALDTVGAVVVDHEGNVAAAVSSGGLALKHPGRVGQAALYGCGCWAENTGAHNPYSTAVSTSGCGEHLVRTILARECSHALQAEDAHQALLETMQNKFISSPFLASEDGVLGGVIVLRSCRCSSESDSSQNKQTLLVEFLWSHTTESMCVGYMSAQDGKAKTHISRLPPGAVAGQSVAIEGGVCRLESPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MPJ4</accession>
    <name>A0A8C2MPJ4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15 18">Synaptic vesicle glycoprotein 2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Sv2b</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263955.1">
        <property type="nucleotide sequence ID" value="XM_027408154.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MPJ4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025113.1">
        <property type="protein sequence ID" value="ENSCGRP00001020869.1"/>
        <property type="gene ID" value="ENSCGRG00001019863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107977027"/>
    <dbReference type="KEGG" id="cge:107977027"/>
    <dbReference type="CTD" id="9899"/>
    <dbReference type="GeneTree" id="ENSGT00950000182940"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="term" value="P:neurotransmitter transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="MFS_SV2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
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    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
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        <property type="entry name" value="SV2"/>
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        <property type="entry name" value="synapt_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23894">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="592"/>
            <end position="613"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="111"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00008335"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027263955.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="77488" checksum="11ECDC45A9F47BD8" modified="2022-01-19" version="1">MDDYRYRDNYEGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKSKQAKMAPSRADGLRGQADMMAERMEDEEQLAHQYETIIDECGHGRFQWTLFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKRVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKTPKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKFIKMYFKHVLFEDTYFDKCFFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFIDCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQL4</accession>
    <name>A0A8C2MQL4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomal protein kizuna</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polo-like kinase 1 substrate 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Kiz</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kizuna family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027277390.1">
        <property type="nucleotide sequence ID" value="XM_027421589.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316971.1">
        <property type="nucleotide sequence ID" value="XM_035461080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MQL4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026433.1">
        <property type="protein sequence ID" value="ENSCGRP00001022188.1"/>
        <property type="gene ID" value="ENSCGRG00001020800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770594"/>
    <dbReference type="KEGG" id="cge:100770594"/>
    <dbReference type="CTD" id="55857"/>
    <dbReference type="OrthoDB" id="8015657at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026742">
        <property type="entry name" value="Centrosomal_kizuma"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16299">
        <property type="entry name" value="CENTROSOMAL PROTEIN KIZUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16299:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN KIZUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027277390.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="76505" checksum="387FB5AEA9C3BD8E" modified="2022-01-19" version="1">MPRGRGGGGVRHDPTASAPLASPSYYERVGQLQQALRDSEQKRLDLEDKLYEYNKSDKCRAKLKCAKLKKYLKEVCESERRAHVRNQGYLKKFQCVQTYVEHLTTNTEKLQKLKTEYEAEMKKMHLLLKGSLGMKDEARVKVGINSRTAMSRGLYQPATIFMGRQMSAISSIDDFSTEQRSKQPTKNCSIPDPHSHQQTAQSSRVTDSCVVQTNSDTQCLNKSDKIDGKTSLQIVEKTPVTSHALSEEEQTHCWEIGSSTRHSKSNLSEGRKSAELHSSLQERLSPENRTTDLKCDSSSRSEGSGGEILTQEHTEVREERASLPVPTLSVSEHCASVGEKHSAWKGFSDDLAHGDPKSPKAFLKMQEEQEEESSCSSSDLTVSVSEEKLSLENLESLLSPGTKLDGEDGRQASWSVYTTLQRDPLITDCSLQTQTFPDSKRESFPDSPRQSEQMPDWHLLKTQGQCMKEHNNSPKEEATALLKKVLTEECDHRSAIHSNESSCSMPSILNDNNGIMEAKPALRLNSVLTREQEVSSGCGDESKEESIAAIPVTGHREADIVPSELFQFSLGATMKETKAYQLMKKSTLQDNLNQTEERFESQFSSLDIGSSIFKTKTAHKIASEASFSSSEGSPLSRHESKRDPVTTIKSNAFWGESDDSNSEIEAALRPRDHNMSDDFDDFYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MSS4</accession>
    <name>A0A8C2MSS4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-responsive element-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Iron regulatory protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Ireb2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with RBCK1 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with CIAO1 and CIAO2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003497952.1">
        <property type="nucleotide sequence ID" value="XM_003497904.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270854.1">
        <property type="nucleotide sequence ID" value="XM_027415053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MSS4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024182.1">
        <property type="protein sequence ID" value="ENSCGRP00001019938.1"/>
        <property type="gene ID" value="ENSCGRG00001019234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756122"/>
    <dbReference type="KEGG" id="cge:100756122"/>
    <dbReference type="CTD" id="3658"/>
    <dbReference type="GeneTree" id="ENSGT00940000157796"/>
    <dbReference type="OMA" id="VYEPMFD"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030350">
        <property type="term" value="F:iron-responsive element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034101">
        <property type="term" value="P:erythrocyte homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050892">
        <property type="term" value="P:intestinal absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000011">
        <property type="entry name" value="Iron-responsive element binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000012">
        <property type="entry name" value="Iron-responsive element binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000005">
        <property type="entry name" value="Iron-responsive element-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="16">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="16">
        <location>
            <begin position="213"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="17">
        <location>
            <begin position="768"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027270854.1"/>
        </source>
    </evidence>
    <sequence length="963" mass="104956" checksum="ED4C25691E6718D6" modified="2022-01-19" version="1">MDSPSAGYTFEYLIETLSGNPHKKFFNVPKLGGTKYDILPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVVLQDFTGIPAMVDFAAMREAVKSLGGDPKKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKFPCRGQTTCRGSCDSGELSRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSGAFKNVAVIPPGTGMAHQVNLEYLSRVVFEEKDLLFPDSVIGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDKTKLESMEKYLKAVKLFRNDENSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAITDMKSDFQACLNEKVGFKGFQVAAEKQSDTVSIHYDGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVETGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSEAVLNAVKQGDLVTCGVLSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDSTGKEIYLNDIWPSREEVHQIEEEHVVLSMFKALKEKVELGNKRWNSLEAPESVLFPWDVKSTYIRCPSFFDKLTKEPAVLQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVYEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSLGLSGREVFSLSFPEELSPGITLNMKTSTGKEFSVIASFENDVEITLYKHGGLLNFVARKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MTP9</accession>
    <name>A0A8C2MTP9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16 17" type="primary">LOC100767925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16 17">17A/GY</strain>
            <tissue evidence="16 17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TSC-TBC complex (also named Rhebulator complex), composed of 2 molecules of TSC1, 2 molecules of TSC2 and 1 molecule of TBC1D7. Interacts with TSC1 (via C-terminal half of the coiled-coil domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003497987.1">
        <property type="nucleotide sequence ID" value="XM_003497939.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007618115.1">
        <property type="nucleotide sequence ID" value="XM_007619925.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266234.1">
        <property type="nucleotide sequence ID" value="XM_027410433.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266235.1">
        <property type="nucleotide sequence ID" value="XM_027410434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MTP9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026292.1">
        <property type="protein sequence ID" value="ENSCGRP00001022047.1"/>
        <property type="gene ID" value="ENSCGRG00001020708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767925"/>
    <dbReference type="KEGG" id="cge:100767925"/>
    <dbReference type="GeneTree" id="ENSGT00390000009122"/>
    <dbReference type="OMA" id="VMHTMWL"/>
    <dbReference type="OrthoDB" id="18718at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070848">
        <property type="term" value="P:response to growth factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000006">
        <property type="entry name" value="TBC1 domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000028">
        <property type="entry name" value="TBC1 domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.680:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.680">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039842">
        <property type="entry name" value="TBC1D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043039">
        <property type="entry name" value="TBC1D7_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="50"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027266234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027266235.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33772" checksum="324AAEF96A95B490" modified="2022-01-19" version="1">MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDPLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHDSHAQVMAYRKDQYSDVLHALTVVRFISDATPQVEVYLRMYQLESGKLPRSPSFPMEPEDEVFLAIAKAMEEMVEDSIDCYWLTRCFVKQLHSKFRDSLPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSVEKITEFLENIPQDSSDAIVSKAIDLWHKHCGTPAHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MVB0</accession>
    <name>A0A8C2MVB0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Spon1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027265931.1">
        <property type="nucleotide sequence ID" value="XM_027410130.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MVB0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027002.1">
        <property type="protein sequence ID" value="ENSCGRP00001022757.1"/>
        <property type="gene ID" value="ENSCGRG00001021186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771703"/>
    <dbReference type="KEGG" id="cge:100771703"/>
    <dbReference type="CTD" id="10418"/>
    <dbReference type="GeneTree" id="ENSGT00940000154910"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050693">
        <property type="term" value="F:LBD domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902430">
        <property type="term" value="P:negative regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902993">
        <property type="term" value="P:positive regulation of amyloid precursor protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010954">
        <property type="term" value="P:positive regulation of protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000026">
        <property type="entry name" value="Spondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000013">
        <property type="entry name" value="Spondin 1a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000001">
        <property type="entry name" value="Spondin 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000024">
        <property type="entry name" value="Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000034">
        <property type="entry name" value="Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000081">
        <property type="entry name" value="Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4060:FF:000002">
        <property type="entry name" value="Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679012" description="Spondin-1" evidence="14">
        <location>
            <begin position="29"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="15">
        <location>
            <begin position="29"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="16">
        <location>
            <begin position="195"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027265931.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="90937" checksum="1D2D2B5CF3CB0FA1" modified="2022-01-19" version="1">MRLSPAPLRLSRGPALLALALPLAVALAFSDETLDKVSKSEGYCSRILRAQGTRREGYTEFSLRVEGDPEFYKPGSSYRVTLSAAPPSYFRGFTLIALKENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPTGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDPSLDGVTDRPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPVNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCEKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPRSCLVTEWGEWDDCSATCGMGMKKRHRMIKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEELEQVEKCMLPECPIDCELSEWSQWSECNKSCGKGHMIRTRTIQMEPQFGGVPCPETVQRKKCRARKCLRNPSVQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N251</accession>
    <name>A0A8C2N251_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">F-box only protein 5 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">F-box protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Fbxo5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007643099.2">
        <property type="nucleotide sequence ID" value="XM_007644909.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256827.1">
        <property type="nucleotide sequence ID" value="XM_027401026.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N251"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031376.1">
        <property type="protein sequence ID" value="ENSCGRP00001027129.1"/>
        <property type="gene ID" value="ENSCGRG00001024225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773759"/>
    <dbReference type="KEGG" id="cge:100773759"/>
    <dbReference type="CTD" id="26271"/>
    <dbReference type="GeneTree" id="ENSGT00530000063692"/>
    <dbReference type="OrthoDB" id="9984940at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072687">
        <property type="term" value="C:meiotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990948">
        <property type="term" value="F:ubiquitin ligase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000773">
        <property type="term" value="P:negative regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032876">
        <property type="term" value="P:negative regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045841">
        <property type="term" value="P:negative regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070169">
        <property type="term" value="P:positive regulation of biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905322">
        <property type="term" value="P:positive regulation of mesenchymal stem cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007057">
        <property type="term" value="P:spindle assembly involved in female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20364">
        <property type="entry name" value="BRcat_RBR_FBXO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000006">
        <property type="entry name" value="F-box only protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044064">
        <property type="entry name" value="ZF_ZBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF8">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51872">
        <property type="entry name" value="ZF_ZBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZBR-type" evidence="15">
        <location>
            <begin position="350"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027256827.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48092" checksum="01B445A39EE42E2E" modified="2022-01-19" version="1">MSRRVCSGLPRPSSCPCGLGARTVADGCKEGSPVLSIKMKCFNCNPDLSELEVVKPEDSGRQGSYNPVCLEPSCKDCFRNQERLSFIESPTVGHDNNKENQHVQKILNSPSEIEELEASRLYEDSGYLSFTHQSDQEDSTLILENFRNSPQPCLLPSQSSDQYPNKNLLPLLEFERVVCSTLKKNSKRNPKVDREMLKEFIASGNFRLQNIIGKKMGLEHLDILSELSRRGFKHLLANILTKLGDMDLINLSKVSKIWKKIVESDKRAFQLYSKAMQRVLESSKLSLHSSTRGYVVGRTALTSVQKSSTWAPPKKDAQAKFPRQRDQKGSAYSRHSEFLEVAKTLKNNESLKACIRCNFPAKYDHYLERATCKRESCGFDYCTKCLCDYHNNTKDCSNGKLLKASCKITTGPLPGTKKSKKNLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QDR1</accession>
    <name>A0A8C2QDR1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100755329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263305.1">
        <property type="nucleotide sequence ID" value="XM_027407504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QDR1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006046.1">
        <property type="protein sequence ID" value="ENSCGRP00001004079.1"/>
        <property type="gene ID" value="ENSCGRG00001005111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755329"/>
    <dbReference type="KEGG" id="cge:100755329"/>
    <dbReference type="OrthoDB" id="6144443at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15951">
        <property type="entry name" value="7tmA_OR52R_52L-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF156">
        <property type="entry name" value="OLFACTORY RECEPTOR 52R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="48"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027263305.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35818" checksum="C9065B631D961ACF" modified="2022-01-19" version="1">MTHSLMLPSRNISSHATFFILLGIPGLENYQFWVAFPFCVMYIVAVTGNITILHIIRIDHTLHGPMYLFLAMLATTDLILSSSTQPKMLAILWFHDHKIEYHACLIQVFFIHAFSSVESGVLMAMALDRYVAICFPLRHSSILTTSVVIKLGAAVMVRGLLWVSPFCFMISRMPFCPNKVIPQSYCEHMAVLKLVCADIRINRGYGLFVAFSVASFDIIVISLSYVMILKAVLRLPSGEARLKAFGTCASHIGVILTLYIPALFTFLTHRFGHHVPRVVHIMFANVYLLVPPMLNPIIYGVRTKQIRDRVIQGCCGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QGY3</accession>
    <name>A0A8C2QGY3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Alpha-parvin isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Parvin, alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Parva</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the parvin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027265902.1">
        <property type="nucleotide sequence ID" value="XM_027410101.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QGY3"/>
    <dbReference type="SMR" id="A0A8C2QGY3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015112.1">
        <property type="protein sequence ID" value="ENSCGRP00001010884.1"/>
        <property type="gene ID" value="ENSCGRG00001012664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763027"/>
    <dbReference type="KEGG" id="cge:100763027"/>
    <dbReference type="CTD" id="55742"/>
    <dbReference type="GeneTree" id="ENSGT00950000183194"/>
    <dbReference type="OrthoDB" id="2099265at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein kinase inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21335">
        <property type="entry name" value="CH_PARVA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21337">
        <property type="entry name" value="CH_PARVA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Parvin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000011">
        <property type="entry name" value="Parvin, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF6">
        <property type="entry name" value="ALPHA-PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039131">
        <property type="entry name" value="Parvin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="95"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="262"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027265902.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42268" checksum="D85ED1A9800F5924" modified="2022-01-19" version="1">MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSEFQEEGMNAINLPLSPISFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EXS3</accession>
    <name>A0A9J7EXS3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100762857</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027242326.1">
        <property type="nucleotide sequence ID" value="XM_027386525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EXS3"/>
    <dbReference type="GeneID" id="100762857"/>
    <dbReference type="KEGG" id="cge:100762857"/>
    <dbReference type="OrthoDB" id="9523733at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="45"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027242326.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34728" checksum="ABE71AF712B9A754" modified="2023-06-28" version="1">MFNNKNMQNTTSVLEFHFIQLSEDPDLQPVLSGLFLSMYILALLGNLLIILTVSSDSHLHTPMYFFLSSLSMVDIGFISTTVPRVIVDIQTHCPVISYVGCLTQMSLFIIFGCMDSMLLVVMAYDRFVAICHPLYYQVIMNPSSCGVLLLGCFLLSLAELLLHFVAVLNFSNCEDYVEISTFFCDPSELLKIACFDTVTSSIVRYCAGALFGLPSVSGIIFSYFKIVSSIMRSPSSSGKQKTFSTCGSHLSIVCLFYGTALGVYFSSSLSHSPRSVAVASVMYTVVTPTLNPFIYSLRNKDIKTALRKILSRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F1C7</accession>
    <name>A0A9J7F1C7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Slc4a7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027245164.1">
        <property type="nucleotide sequence ID" value="XM_027389363.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285492.2">
        <property type="nucleotide sequence ID" value="XM_027429691.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F1C7"/>
    <dbReference type="GeneID" id="100770901"/>
    <dbReference type="KEGG" id="cge:100770901"/>
    <dbReference type="CTD" id="9497"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060117">
        <property type="term" value="P:auditory receptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF105">
        <property type="entry name" value="SODIUM BICARBONATE COTRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1100"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="17">
        <location>
            <begin position="115"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="17">
        <location>
            <begin position="417"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="16">
        <location>
            <begin position="593"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="294"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027245164.1"/>
        </source>
    </evidence>
    <sequence length="1256" mass="140086" checksum="5A283B5AC2084000" modified="2023-06-28" version="1">MEADGAGEQMRPLLTRGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYVGVHVPFSKESRRRHKHRGHKHHHRRRKDKDSDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDDSIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLSHLLPSSRAGTPAGSRCTTPVPTPQSSPPSSPGLSRLASRSSQQSQPQAPELLVSPNRDDIPRVVIHPPEEDIEALKGQEQKTEENVDFTPGNCAEFSTCGILASPQSAPGNLDNSKSGEMKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLSGLTEVPVPTRFLFLLLGPAGKASQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFPNGSAPVSTEPPNEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFHLGEIYAFNMHNNLDELTSYTCICAEPSNPSNETIELWKRKNVTADSILWGNLTVSECKAFHGMFVGSACGPHGPYVPDVLFWCVVLFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVAIDYLVGIPSPKLNVPEKFEPTDPSRGWIISPLGDNPWWTLLIAAVPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSIMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQFFDRIKLFGMPAKHQPDLIYLRYVPLWKVHVFTVIQLTCLVLLWVIKASAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDGDTVHLPFERGSLLKYSIDPSVVNISDEMAKTAQWKALSMNTENAKVTRPNTSPEKPVSVTINFEDEPSKKYMDAETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F5T7</accession>
    <name>A0A9J7F5T7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras association domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rassf3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027248101.1">
        <property type="nucleotide sequence ID" value="XM_027392300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F5T7"/>
    <dbReference type="GeneID" id="100770379"/>
    <dbReference type="KEGG" id="cge:100770379"/>
    <dbReference type="CTD" id="283349"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21891">
        <property type="entry name" value="SARAH_RASSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000224">
        <property type="entry name" value="ras association domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF8">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="79"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="8">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027248101.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26662" checksum="1BA9E399F24D9E0D" modified="2023-06-28" version="1">MSSGYSSLEEDAEDFFFTARTSFFRRAPPGKSRSGQPDVEKEKETHNYLSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPAQTPPSSSDCVNTLHISSTNTVGEVIEALLKKFLVTESPTKFALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGEWEAFSLPELQNFLRILDKEEDEQLQSLKRRYTAYRQKLEEALGEVWKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F8S9</accession>
    <name>A0A9J7F8S9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">F-BAR domain only protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">Fcho1</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14 15">17A/GY</strain>
            <tissue evidence="13 14 15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FCHO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027250569.1">
        <property type="nucleotide sequence ID" value="XM_027394768.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250573.1">
        <property type="nucleotide sequence ID" value="XM_027394772.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250574.1">
        <property type="nucleotide sequence ID" value="XM_027394773.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250575.1">
        <property type="nucleotide sequence ID" value="XM_027394774.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284210.1">
        <property type="nucleotide sequence ID" value="XM_027428409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F8S9"/>
    <dbReference type="GeneID" id="100772920"/>
    <dbReference type="KEGG" id="cge:100772920"/>
    <dbReference type="CTD" id="23149"/>
    <dbReference type="OrthoDB" id="5593455at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000016">
        <property type="entry name" value="FCH domain only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF6">
        <property type="entry name" value="F-BAR DOMAIN ONLY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="625"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027250569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027250573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027250574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027250575.1"/>
        </source>
    </evidence>
    <sequence length="889" mass="97032" checksum="55093C76CA3DD16E" modified="2023-06-28" version="1">MSYFGEHFWGDKNHGFEVLYHCVKQGPVATKELADFIRERASIEETYSKAMAKLSKMASNGTPMGKDSYAPGCQMHWTLPVPRTFAPLWEVFRVSSDKLALCHLELTRKLHDLLKEVLRYGEEQLKAHKKCKEEVLGTVDAVQVLASVGQLLPKSRENYLSRCMDLERLRRENTSQKEMDKAETKSKKAADSLRRSVDKYNSARADFETKMLDSALRFQAMEESHLQHMKALLGSYAHSVEDTHVQIGQVHEEFKQNVENVTVDMLLRKFAESKGTGCEKPGPLDFDAYSTAALQEAMKRLRGAKAFRLPGLSRREPRAAVDFLESDSGVPPEVDEEGFTVRPDVSHNSMAEPPRFSSSDSDFDDEEPRKFYVHIKPAPTRTVTCSSEAAAAQLRATAGSLILPPGPGGTMKRHSSRDTSGKPQRPRSAPRTGSCAEKPLASEELLSKNLFGPPLESAFDHEDFTGRGGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPESWVPRPGTPQSPPACRTQHPEARGPTPRAPSPGPWGPEAGADSTTREGLAAPPRRPRSRKVSCPLTRSNGDLGRSLSPSPLGLSAPSITSDRPSFSTQMGHGISRGPSPVVLGSQDTLPVATAFTEYVHAYFRGHSPSCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTAPVEHFQPNTDLIFSDPSQSDPETKDFWLNMSALTEALQHQAEQNPTASYYNLVLLRYQFSRPGPESVPLQMSAHWQCGPTLTRVTVEYSYRAGATAVSTPLTNVQILLPVGEPVTSVRLQPAASWNTEEKRFTWKLPDVCEAGGSGRLSASWQPQTGPSTPSPVAAQFTSEGATLSGLDLELLGGGYRMSLVKRRFATGMYLASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F9V6</accession>
    <name>A0A9J7F9V6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Putative hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="4 7">5.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Hyi</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate</text>
            <dbReference type="Rhea" id="RHEA:11952"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="5.3.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the hyi family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22" evidence="4 7"/>
    <dbReference type="RefSeq" id="XP_007641476.2">
        <property type="nucleotide sequence ID" value="XM_007643286.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254853.1">
        <property type="nucleotide sequence ID" value="XM_027399052.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F9V6"/>
    <dbReference type="GeneID" id="100774763"/>
    <dbReference type="KEGG" id="cge:100774763"/>
    <dbReference type="CTD" id="81888"/>
    <dbReference type="OrthoDB" id="4214675at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000011">
        <property type="entry name" value="Putative hydroxypyruvate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050417">
        <property type="entry name" value="Sugar_Epim/Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489:SF6">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489">
        <property type="entry name" value="ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027254853.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30361" checksum="7463ECD6BE35EA5A" modified="2023-06-28" version="1">MAPLRFSANVSWLFPELPGLPERLQAAGRAGFEAAEVAWPYAEPPQALASAARAAGLRLVLINTPRGNQEKGEMGLGAVPGRQAAFREGLEQAVLYAKALGCPRIHLMAGRVPQGADRAAIQGEMETVFLENLKYAAGVLAQENLVGLLEPINTRITDPQYFLDTPQQAAAILQKVGRPNLQLQMDIFHWQIMGGNLTANIREFLPIVGHVQVAQVPDRGEPGSSGELDFSYLFQLLEDEGYQGFVGCEYRPRGDTVEGLSWLRSYWDRRGHPQTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FB50</accession>
    <name>A0A9J7FB50_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger and BTB domain-containing protein 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger protein 151</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Zbtb17</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255726.1">
        <property type="nucleotide sequence ID" value="XM_027399925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FB50"/>
    <dbReference type="GeneID" id="100754046"/>
    <dbReference type="KEGG" id="cge:100754046"/>
    <dbReference type="CTD" id="7709"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18206">
        <property type="entry name" value="BTB_POZ_ZBTB17_MIZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000831">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000048">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001021">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001022">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001032">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000225">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 17 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000346">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 17 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF8">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="18">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="119"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027255726.1"/>
        </source>
    </evidence>
    <sequence length="798" mass="87287" checksum="06199026999C7665" modified="2023-06-28" version="1">MAAMDFPQHSQRVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVASFLQMQDIITACHALKSLAEPSSSTGEDTEVSAVEGGDKRAKEEKAAATPLSRLDQASSSPHTGPGRELKEERGGQAQSTASGAEQTEKADAPREPPSVELKPDPTSGMAAAEAEALSESSEQEMDVEPASKGEEEEHEEEGTGPATVKEEGMHLENGETPEENEESAGTDSGQELSMEGRNLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLLSLLNLHKKRHSGEARYGCGDCGKLFTTSGNLKRHQLVHSGQKPYQCDYCGRSFSDPTSKMRHLETHDTNKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCTHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGGEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGSTWPAGQMLQAGELVFRPRDGAEGHPTLAETPPTAPDCPPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FCW0</accession>
    <name>A0A9J7FCW0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: opioid growth factor receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC113833695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027253821.1">
        <property type="nucleotide sequence ID" value="XM_027398020.2"/>
    </dbReference>
    <dbReference type="GeneID" id="113833695"/>
    <dbReference type="KEGG" id="cge:113833695"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF1">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="85"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027253821.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56470" checksum="03E840FB6FFE1B26" modified="2023-06-28" version="1">MDDQDCDSTWEDESEEDRKDGQADDKGEEDTGDEDGNAEETRLGVFQSRMAGYRNWQAMQDMQRYRYHYPDLADQDCNGKFFTTELLQNEICFQPNGLFIEEILHNWKDNYDLLEENHSYIQWLFPLREPGVNWHAKPLTLQEFEAFKSSEEVKEHLVRACELMLDFYGIQLEDRDTGAVCRAQNFQPRFHNLNSHSHNNLRITRILKPLGELGLEHNQAPLVCFFLEETLVQHKLPSMPLSVLDYFLFAVCCRHQRRELVYFAWEHFRPRCQFVWGPRDKLRRFRTYGIPRPLMVLGQADKDEGFGSPFQEAVTQGRTYGSGRDLSGDSGTAEDPSLLSTNPQDSGTLDEDQGDEAESLSPKESKKRKLEGNRQEQVPGESDVEKTALSLEGCALSSISQEPREAEQPCPVTHGTRVADEVRKRRKMEERTESDXVASNHHTDLQAHALPPTPSEGPEAQKDENGPEDPESQVGPEQGKVPLGAWWTLILTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FFG3</accession>
    <name>A0A9J7FFG3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">LOW QUALITY PROTEIN: sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">St8sia3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258560.2">
        <property type="nucleotide sequence ID" value="XM_027402759.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100764454"/>
    <dbReference type="KEGG" id="cge:100764454"/>
    <dbReference type="CTD" id="51046"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23970">
        <property type="entry name" value="GT29_ST8SIA3_oligo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000001">
        <property type="entry name" value="ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF36">
        <property type="entry name" value="SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA 2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027258560.2"/>
        </source>
    </evidence>
    <sequence length="527" mass="59518" checksum="2D405E9C1AAB6E10" modified="2023-06-28" version="1">MQPNCSKPDAGVHRPSTERRALEGHRGKPSTLKRDPSFMAGSRGRTAWRASSPCRLADPPSSCSVPGQARPCPRGGVGGRLPLLPGLQVVPHPLPSTTQLPGPPPPPHTLTRAREHTRTHTHTHTPADCWPLNGPISPVSLNPAXPGMRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKYANPGAPRMYMFHAGFRSQFALKFLDPSFVPITNSLTHELQEKPSKWTFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKRYNVCAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAVCEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FHG0</accession>
    <name>A0A9J7FHG0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Snx24</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in several stages of intracellular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027256699.1">
        <property type="nucleotide sequence ID" value="XM_027400898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FHG0"/>
    <dbReference type="GeneID" id="100773139"/>
    <dbReference type="KEGG" id="cge:100773139"/>
    <dbReference type="CTD" id="28966"/>
    <dbReference type="OrthoDB" id="93876at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06880">
        <property type="entry name" value="PX_SNX22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000038">
        <property type="entry name" value="sorting nexin-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052467">
        <property type="entry name" value="Sorting_nexin_PX-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813">
        <property type="entry name" value="SORTING NEXIN-22 AND 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813:SF10">
        <property type="entry name" value="SORTING NEXIN-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027256699.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24390" checksum="F1675692899DCDC6" modified="2023-06-28" version="1">MEVYIPSFRHEDSDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPSKHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKAESCGSFDETESEESSKLSHQPVLLFLGDPYVLPAASAYFELEKEGIKIFQMWSSKEFFMEYFTLTCSPGRNPTWPDEAEASFSVNGKKIDSSTNLPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FHV3</accession>
    <name>A0A9J7FHV3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase RYK</fullName>
            <ecNumber evidence="4">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC100757154</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with DVL1 (via PDZ domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027257015.1">
        <property type="nucleotide sequence ID" value="XM_027401214.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100757154"/>
    <dbReference type="KEGG" id="cge:100757154"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060071">
        <property type="term" value="P:Wnt signaling pathway, planar cell polarity pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05043">
        <property type="entry name" value="PTK_Ryk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000165">
        <property type="entry name" value="Tyrosine-protein kinase RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2170:FF:000002">
        <property type="entry name" value="Tyrosine-protein kinase RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000218">
        <property type="entry name" value="Tyrosine-protein kinase RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="WIF" evidence="25">
        <location>
            <begin position="97"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="370"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00071256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027257015.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="71080" checksum="FA9DB7DD7092CC9D" modified="2023-06-28" version="1">MTQLEVSDADNKMTKCARGRGARRRSAAAAGGGHSCSAAAIRAGRGDXPGTGGLRSPPPPLLLLLLLLALLPAAAPRSPALVAAPVGPSMSLYLSEDEVRRPLGCRLLGLDAELYYVRNDLISHYALSFNLLVPSESNFLHFTWHAKSKVEYTLGLQVDNFVAMGMPQVNISAQGEVPHTLSVFRVELSCTRKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYVPVHAAPTTSRRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSXPSTQTTQYLRADTPNNATPITSSSGYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERITLKDVLQKVSTFGHIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLQGLHHRNLLPITHVCKEEGGKPMVILPYMNWGNLKLFLQQCKLVEANNPQAISQQDLGHMAIQIACGMSYLARREVIHKDLAARNCVIDNTLQVKITDNALSRVLFPIDYHCLGDNENRPVRWVALESLVNNEFSSAGDVWAFGVTLWELMTLGQTPYVDIDPFEMAAFLKDGYRMAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FZY8</accession>
    <name>A0A9J7FZY8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform</fullName>
            <ecNumber evidence="6">2.7.1.153</ecNumber>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Serine/threonine protein kinase PIK3CB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">Pik3cb</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
            <tissue evidence="32">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77137"/>
            <dbReference type="ChEBI" id="CHEBI:83243"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:43397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.153"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:21293"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4. Interacts with BECN1, ATG14 and RAB5A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.153" evidence="6"/>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_027270061.1">
        <property type="nucleotide sequence ID" value="XM_027414260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FZY8"/>
    <dbReference type="GeneID" id="100689252"/>
    <dbReference type="KEGG" id="cge:100689252"/>
    <dbReference type="CTD" id="5291"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046934">
        <property type="term" value="F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08693">
        <property type="entry name" value="C2_PI3K_class_I_beta_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00872">
        <property type="entry name" value="PI3Ka_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05173">
        <property type="entry name" value="PI3Kc_IA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000046">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000004">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000005">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.770:FF:000003">
        <property type="entry name" value="phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037702">
        <property type="entry name" value="PI3-kinase_beta_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like"/>
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    </dbReference>
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        <property type="entry name" value="PI3_4_KINASE_1"/>
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    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
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    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
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    <keyword evidence="16" id="KW-0072">Autophagy</keyword>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="11" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="26"/>
            <end position="115"/>
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        <location>
            <begin position="194"/>
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        <location>
            <begin position="335"/>
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            <begin position="532"/>
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        <location>
            <begin position="780"/>
            <end position="1061"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023006"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023098"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023981"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00080896"/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G150</accession>
    <name>A0A9J7G150_CRIGR</name>
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        <submittedName>
            <fullName evidence="6">CD209 antigen-like protein A isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100756903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027271859.1">
        <property type="nucleotide sequence ID" value="XM_027416058.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="100756903"/>
    <dbReference type="KEGG" id="cge:100756903"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C-type_lectin-like"/>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051379">
        <property type="entry name" value="C-type_Lectin_Receptor_IMM"/>
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    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746:SF9">
        <property type="entry name" value="CD209 ANTIGEN-LIKE PROTEIN C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2"/>
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        <property type="entry name" value="Lectin_C"/>
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    </dbReference>
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        <property type="entry name" value="CLECT"/>
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    </dbReference>
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        <property type="entry name" value="C-type lectin-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="74"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027271859.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22351" checksum="266D814811B244AB" modified="2023-06-28" version="1">MNVDGCQACDRFITVLQLISLVLLAALLVAILVKGSYLPSSQEQEKQHIHQELDQLKAGLDHLCRPCPWDWTLFQGNCYFFSTYQQAWKDSVTACKEIGAQLVVIKSDEEQSFLQQTSKKKNYTWMGLSDLKQEGRWLWVDGSLLKWRKYWSPREPNNKGDEDCAAFSDNGWTDNLCSLEQFWICKKPASTCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G3A1</accession>
    <name>A0A9J7G3A1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Major facilitator superfamily domain-containing protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Mfsd12</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine(in) = L-cysteine(out)</text>
            <dbReference type="Rhea" id="RHEA:29655"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29656"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Melanosome membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007645153.2">
        <property type="nucleotide sequence ID" value="XM_007646963.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275033.1">
        <property type="nucleotide sequence ID" value="XM_027419232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G3A1"/>
    <dbReference type="GeneID" id="100771307"/>
    <dbReference type="KEGG" id="cge:100771307"/>
    <dbReference type="CTD" id="126321"/>
    <dbReference type="OrthoDB" id="1730117at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043474">
        <property type="term" value="P:pigment metabolic process involved in pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048021">
        <property type="term" value="P:regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17491">
        <property type="entry name" value="MFS_MFSD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000206">
        <property type="entry name" value="Major facilitator superfamily domain containing 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000219">
        <property type="entry name" value="major facilitator superfamily domain-containing protein 12 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027275033.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="51577" checksum="26F55889C326CB74" modified="2023-06-28" version="1">MSPPPGGAGPGPPRTLSPAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQAADGLCTPLVGYEADRAACARCGPRKAWHLAGTVCVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVYGAAWLLLHLQGSSHAGQDISVGDQLGVQDVPVFRNLALMVVGVGAIFSLLFHLGTKEGRRPCPREMEPDEHSPLVAPTARPLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFLSSFLMKPVNRRIGRNMTYFSGLLVILAFAAWVALVDKLGVAVYGAAVLLGAGCATVLVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVMAVQSLHPCPSELCCRACVGFYHWVMVTVTGGVGVAAALALCSLLIWPIRIRTRTGDPRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G4J2</accession>
    <name>A0A9J7G4J2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Pdk1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_027275993.1">
        <property type="nucleotide sequence ID" value="XM_027420192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G4J2"/>
    <dbReference type="GeneID" id="100774056"/>
    <dbReference type="KEGG" id="cge:100774056"/>
    <dbReference type="CTD" id="5163"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF14">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="268"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027275993.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49360" checksum="668344C8F3586512" modified="2023-06-28" version="1">MRLARLLRGGRGIRPRREVPSASRSLASASASGPGPESERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAISPGQTIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGEEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRFETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYKTNHEADDWCVPSREPKDMTTFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G5F4</accession>
    <name>A0A9J7G5F4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100774772</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cell membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003505254.1">
        <property type="nucleotide sequence ID" value="XM_003505206.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276930.1">
        <property type="nucleotide sequence ID" value="XM_027421129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G5F4"/>
    <dbReference type="GeneID" id="100774772"/>
    <dbReference type="KEGG" id="cge:100774772"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15410">
        <property type="entry name" value="7tmA_OR5D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="43"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027276930.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35422" checksum="F8B95ED4D00B85C0" modified="2023-06-28" version="1">MVLDMGNQSSVTMFILLGFSEYPHLRAPLFLLFFITYMVTLIGNLGIIVVRRINPKLHTPMYFFLSHLSLLDICYSSVFTPKLLEILIVEDRTISFKGCMTQFFFICAFVITEMFMLAVMAYDRFVAVCNPLLYTVAMSPKLCALLVAGTYMWGVFCSLTITYSLLQLSYCGPNIINHFGCEYSAILSLSCSDPTFSQVICLIISIFNETCSLLIILASYVFIVVTIIKMPSKGGFQKALSTCSSHLTAISIFHGIILLLYCVPNSKNSWLVVKVATVLFTVMIPMLNPLIYSLRNKDVKGTVSRLMTLKLHSHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G601</accession>
    <name>A0A9J7G601_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Actr5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027277039.1">
        <property type="nucleotide sequence ID" value="XM_027421238.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035294832.1">
        <property type="nucleotide sequence ID" value="XM_035438941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G601"/>
    <dbReference type="GeneID" id="100765489"/>
    <dbReference type="KEGG" id="cge:100765489"/>
    <dbReference type="CTD" id="79913"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033044">
        <property type="term" value="P:regulation of chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051052">
        <property type="term" value="P:regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000098">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000122">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000016">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000019">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027277039.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="70745" checksum="F8938E6BED08792E" modified="2023-06-28" version="1">MEANVFRFRDARAAPDPVLEAEPVAFGSQPVPLVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGRGGARGGPGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYRIPKVAYGIDSLFSFYHNMPKNALSSGLIISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILQEHSYIAEDYGAELQKWRCPDYYENNVHKMQLPFSNKLLGSTLTAEEKQERRQQQLRRLQELNARRREEKLQLDQERLERLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLTLAVEQAKQKILQAEANLEVDVVDSKPEVIPQQLHQSATTSLSCQSALLESSTPDLEQLEPSLEDVESINDFEPLFSEEAPEVEKPVTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARMEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDHLEDSGAWVTRKDYEEKGGEYLKEHCASNTYVPIRLPKQASRASETQTSGRGSGASGSGAGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GCM4</accession>
    <name>A0A9J7GCM4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FLYWCH family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Flywch2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_016818635.1">
        <property type="nucleotide sequence ID" value="XM_016963146.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280683.1">
        <property type="nucleotide sequence ID" value="XM_027424882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GCM4"/>
    <dbReference type="GeneID" id="103162685"/>
    <dbReference type="KEGG" id="cge:103162685"/>
    <dbReference type="CTD" id="114984"/>
    <dbReference type="OrthoDB" id="9836688at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029279">
        <property type="entry name" value="FLYWCH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040312">
        <property type="entry name" value="FWCH1/FWCH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31665:SF0">
        <property type="entry name" value="FLYWCH FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31665">
        <property type="entry name" value="FLYWCH FAMILY MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15423">
        <property type="entry name" value="FLYWCH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FLYWCH-type zinc finger-containing protein N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027280683.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="15722" checksum="6EB2E8755DEDE171" modified="2023-06-28" version="1">MWPEGQASGPGMPQPKPSEQEGESMKAGQEPTPQPGTDVVPAAPRKPRKCSKLVLLTASKDSAKVAGAKRKGVHCIMSLGVPGPATLAKALLKTHPEAQRAIEAAPQEPEQKRSKLDPDTGGPEDNGWSGVSSSSPEKETTMLPKAPSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GHC3</accession>
    <name>A0A9J7GHC3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb-related transcription factor, partner of profilin isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mypop</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027286766.1">
        <property type="nucleotide sequence ID" value="XM_027430965.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GHC3"/>
    <dbReference type="GeneID" id="113837301"/>
    <dbReference type="KEGG" id="cge:113837301"/>
    <dbReference type="CTD" id="339344"/>
    <dbReference type="OrthoDB" id="9940550at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052870">
        <property type="entry name" value="Myb-related_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32345">
        <property type="entry name" value="MYB-RELATED TRANSCRIPTION FACTOR, PARTNER OF PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32345:SF3">
        <property type="entry name" value="MYB-RELATED TRANSCRIPTION FACTOR, PARTNER OF PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027286766.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="42016" checksum="E22F79F4F85EAFBF" modified="2023-06-28" version="1">MASATAAAAPGEAEETTRLRKPRFSFEENQILIREVRAHYPQLYGSQNRRVSVAERRRVWDSIASKINGITSWKRTGQEVQKRWNDFKRRTKEKLARVPHSTQGAGPAAEDTFSTEEETIFAILGPGVAGPGAGAGSEESPAAASSQPQAQSTSTQRYVMSEDRKQDRRADTPAQSKGGSSSPESCSRPSCNPPEAKERESPSPAAMQPVQLPSLALTPPLPAPPPPPTPLAQVAPSSPSPPPRPTTLAPEQSLDFLRAQQETANAIRELAGTLRQGLAKLSEALSALLPLLPGTPADPLPPPPPPPLPPPPKPVLPPPAPKVEMAPEPVSVVAAVVDGAVVAARGVIISPRSEEGVPKPPPPPALPLHLHDSPPHKRKKGFPTRKRRGRWKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJ76</accession>
    <name>A0A9J7GJ76_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pregnancy-specific glycoprotein 22 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100770986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the immunoglobulin superfamily. CEA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027287154.2">
        <property type="nucleotide sequence ID" value="XM_027431353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJ76"/>
    <dbReference type="GeneID" id="100770986"/>
    <dbReference type="KEGG" id="cge:100770986"/>
    <dbReference type="OrthoDB" id="6353782at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007565">
        <property type="term" value="P:female pregnancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05740">
        <property type="entry name" value="IgI_hCEACAM_2_4_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05774">
        <property type="entry name" value="IgV_CEACAM_D1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000340">
        <property type="entry name" value="Carcinoembryonic antigen-related cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000244">
        <property type="entry name" value="carcinoembryonic antigen-related cell adhesion molecule 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050831">
        <property type="entry name" value="CEA_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427:SF1">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0635">Pregnancy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="383"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027287154.2"/>
        </source>
    </evidence>
    <sequence length="499" mass="55997" checksum="E1D02F1AEE74FEB0" modified="2023-06-28" version="1">MALSSVLLYKGYTLWQGLLLTASLLTCWHLSTTAKVTIESVPSPVIEGENVLFSAKNLPENLLAFAWYKRVKSMRFGIGLFSLTSNLSATGPGYSGRETLYRNGSLWLTNVTTKDKGFYTLRTINRSGKVVSTTRMFLRVYSSLFTCGRPHPSALPTIELVPPNFPEGENVLLLAHNLPTNLKALFWYKGVTALRKFEIARHIRAPDLSVQGPAHSGREALFRNGSLMFYNVLWKDNGFYTLRILTTDLKTEIAHVQLQIDTTLSTCCRDLTSAQVTIESKPRYVAEGGSVLLLVHNLPEDLQAFFWYKSVYRTDIFKIAEYSSAIKSTIWGLAHSQRELVYTNGSLLLQNVTNEDAGLYMLETLNRDSKIEKAFVQLHVKKPVTQPFVRLSDTTVTVQSSVVLTCFSADPGISTHWILNKKSLQLTERMKLSKTKCQLTIDPVRREDAGEYKCEVSNPVSSKMSLPVRLTVRKKLLLSSHTIAEWGTSSSKGYKVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GM40</accession>
    <name>A0A9J7GM40_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein NNX3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein phosphatase 1 regulatory subunit 19</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RNA polymerase II subunit 5-mediating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Uri1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92. Interacts with POLR2E/RPB5, RUVBL2 and RUVBL1. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occur in a growth-dependent manner in the mitochondrion. Interacts with UXT. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts (via the middle C-terminal region) with GTF2F1 and GTF2F2. Interacts with DMAP1. Interacts with TSC1 and TSC2. Interacts with PRPF8 and EFTUD2 in a ZNHIT2-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027286105.1">
        <property type="nucleotide sequence ID" value="XM_027430304.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GM40"/>
    <dbReference type="GeneID" id="100753065"/>
    <dbReference type="KEGG" id="cge:100753065"/>
    <dbReference type="CTD" id="8725"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000008">
        <property type="entry name" value="unconventional prefoldin RPB5 interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="220"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027286105.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="59610" checksum="B427DB4B8DCCEFD0" modified="2023-06-28" version="1">MEPEAEPGPLPEAPADAAAAVPLRAPEVLRLREEQEKVVTNCQEKIQHWEKVDNDYNALQERLRTLPDKLSYDVMVPFGPLAFMPGKLVHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVLKNFESRVEFTEDLQKMSDAAGDIVDIREEIKSDFECKGKQRIAHKPHSKPKTSNVFEADFENDVKPKDLPADEELWARLEELERQEELRGELDSNPDTVITNGEDTVSSEEEKEEPGTGTGVNVAPPVTDSSASAGCSMHARNAELPNGQASSHLNRSVIGSHSYHSNGEDEDDDDDDEDDTEEDEDEDGDDSDHTISIDNSVPTIYFFHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRRSGAGSHAPHELPAIRSPADIYRVFVDVVNGEYVPRKSILKSRSRDNSVCSDTSESSAADGDDRRCVLRSLSCEEASEGRGSTLEELQENHPKKLLPSEASEAFSGTVIEKEFSLPPLAPQSAIVHHVLPTIPERKEVLSEGSEEPAKRVSKFKAARLQQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GM43</accession>
    <name>A0A9J7GM43_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC113838740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative pheromone receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027290088.1">
        <property type="nucleotide sequence ID" value="XM_027434287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GM43"/>
    <dbReference type="GeneID" id="113838740"/>
    <dbReference type="KEGG" id="cge:113838740"/>
    <dbReference type="OrthoDB" id="9606139at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016503">
        <property type="term" value="F:pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000033">
        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027290088.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32604" checksum="941334ADC4A950D8" modified="2023-06-28" version="1">MISTDLVMGIIFVSQTTLGMMGNSALLCCFIINEFSGIKARPTDLIVKSLTCANFMVLLCKGIPQTMAAFGWTYFLDSIACKLVFYFHRVARGVSLGSTALLSFFQAIMITPRNAKYKYFKARAYNVIGPSVNMCWPLQMVLNALIPVLVTDLGDGKNCTDFRDLLYCAVAKPHNLTNALYVILLGSSDVMCLVLMLWASGSMVLVLLKHKQRVQYMHRVLCPKSSPETRATQTILVLVSSFVLLYSTSGILTMCLTFVNGTSRGLVHASVATAACFPALCPFLLIKHYTLVTRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GNG7</accession>
    <name>A0A9J7GNG7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin filament-associated protein 1-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Afap1l1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in podosome and invadosome formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with CTTN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Invadopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035294613.1">
        <property type="nucleotide sequence ID" value="XM_035438722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GNG7"/>
    <dbReference type="GeneID" id="100759163"/>
    <dbReference type="KEGG" id="cge:100759163"/>
    <dbReference type="CTD" id="134265"/>
    <dbReference type="OrthoDB" id="9937741at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13306">
        <property type="entry name" value="PH1_AFAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13307">
        <property type="entry name" value="PH2_AFAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000189">
        <property type="entry name" value="Actin filament associated protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000020">
        <property type="entry name" value="Actin filament-associated protein 1-like 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030113">
        <property type="entry name" value="AFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14338:SF1">
        <property type="entry name" value="ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="221"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="419"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="706"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="613"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="711"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="760"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004264"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016930"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035294613.1"/>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GYU2</accession>
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        <name evidence="3" type="primary">LOC118239062</name>
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        <name type="scientific">Cricetulus griseus</name>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">17A/GY</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="KEGG" id="cge:118239062"/>
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            <begin position="20"/>
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            <begin position="83"/>
            <end position="100"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        <source>
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    <sequence length="173" mass="18124" checksum="430BD1895ED5B9AF" modified="2023-06-28" version="1">MVPESRRPLGRSVLGLVSPKFLSLSGSPHPPRIPGPARDTVGTGVREGLPLPTLPEPPQPGLRIRYLAGAPGPRSPRPREQSGRAAGSSSSCSPGAQQGARTAELSPRAEARHPAGARSRGRGPENGPRRPARRALRPIVAARAHPAPSAPAKRVSGPVSRAGLRDARSQRYK</sequence>
</entry>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
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            <taxon>Rodentia</taxon>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035300258.1">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035459397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H0S1"/>
    <dbReference type="GeneID" id="100773244"/>
    <dbReference type="KEGG" id="cge:100773244"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CD209 antigen, isoform CRA_b"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
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        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
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        <property type="entry name" value="C-type_lectin_CS"/>
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    <dbReference type="InterPro" id="IPR033989">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0430">Lectin</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="54"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035300258.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20329" checksum="0CE4A568FBD1F0BF" modified="2023-06-28" version="1">MSDTTEPRLQQLGTLVSKVPSSQVQDKIYQELMQLKIDVHDGLCQPCPRDWTFFHGNCYFFSKSQRNWHNSVTACQEVGAQLVIVETDEEQTFLQQTSKAKGPTWMGLSDMHNEATWHWVDGSTLSPSFEQYWNKGEPNNVGDEDCAEFSKDGWNDLKCDSLNFWICKKASTSSCTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2B0</accession>
    <name>A0A9J7H2B0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glycine amidinotransferase</fullName>
            <ecNumber evidence="15">2.1.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">L-arginine:glycine amidinotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Gatm</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 15">Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:75939"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57486"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:75940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginine + glycine = guanidinoacetate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:13201"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57742"/>
            <dbReference type="EC" id="2.1.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13202"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:75943"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57593"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:75944"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>taurine + L-arginine = taurocyamine + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:75947"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58064"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:75948"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the amidinotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.4.1" evidence="15"/>
    <dbReference type="RefSeq" id="XP_035302355.1">
        <property type="nucleotide sequence ID" value="XM_035446464.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313231.1">
        <property type="nucleotide sequence ID" value="XM_035457340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H2B0"/>
    <dbReference type="GeneID" id="100771783"/>
    <dbReference type="KEGG" id="cge:100771783"/>
    <dbReference type="CTD" id="2628"/>
    <dbReference type="OrthoDB" id="10264242at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015068">
        <property type="term" value="F:glycine amidinotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21136">
        <property type="entry name" value="amidinotransferase_AGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000005">
        <property type="entry name" value="Glycine amidinotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033195">
        <property type="entry name" value="AmidinoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488">
        <property type="entry name" value="GLYCINE AMIDINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488:SF1">
        <property type="entry name" value="GLYCINE AMIDINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="14">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="14">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR633195-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035302355.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34047" checksum="0E42227D4BE5B82D" modified="2023-06-28" version="1">MCNILKTEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSLIKDYFHRGAKWTTAPKPTMADELYDKDYPIHSVEDRHKLASQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPSPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEAPIQKMFEKLGIRTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2V7</accession>
    <name>A0A9J7H2V7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Src-like-adapter 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Src-like adapter protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Sla2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035302708.1">
        <property type="nucleotide sequence ID" value="XM_035446817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754074"/>
    <dbReference type="KEGG" id="cge:100754074"/>
    <dbReference type="CTD" id="84174"/>
    <dbReference type="OrthoDB" id="9924021at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10344">
        <property type="entry name" value="SH2_SLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000224">
        <property type="entry name" value="Src like adaptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000064">
        <property type="entry name" value="src-like-adapter 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035052">
        <property type="entry name" value="SLAP_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 16" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="97"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Cricetulus griseus</name>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
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                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">17A/GY</strain>
        </source>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="4">17A/GY</strain>
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        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
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        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="64"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="203"/>
            <end position="233"/>
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        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035303265.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25226" checksum="0F4B5365FF80B5CC" modified="2023-06-28" version="1">MRFLLLWFIPSRSPSGSATTSTPLAPGHQETRPLPPRPARPRNALRSGQAPSKSPSRKFTSRPPRALRVGRAAAVLPAPPPAAGRHWPQRPARSAFTRADWAPCWEGRFADVLPLPAAARTASGCASRPPRSASGQARCRCRRRCRYCRRPRRFLCFLWRASGRLVPSRRHVARPPPARRPCSVAPSTAPLAWGPLASLRARPHGRGSALSVPGEARPWNGRGGAGALRPAGG</sequence>
</entry>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">17A/GY</strain>
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    <reference evidence="12" key="2">
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                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
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    <reference evidence="13" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
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        <source>
            <strain evidence="13">17A/GY</strain>
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        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H478"/>
    <dbReference type="GeneID" id="100761120"/>
    <dbReference type="KEGG" id="cge:100761120"/>
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    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052477">
        <property type="entry name" value="Orphan_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 142-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="106"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035303104.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H7R2</accession>
    <name>A0A9J7H7R2_CRIGR</name>
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        <recommendedName>
            <fullName evidence="14">Zinc finger protein 579</fullName>
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    <gene>
        <name evidence="19" type="primary">LOC113837246</name>
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    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305279.1">
        <property type="nucleotide sequence ID" value="XM_035449388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H7R2"/>
    <dbReference type="GeneID" id="113837246"/>
    <dbReference type="KEGG" id="cge:113837246"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000111">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000344">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24383">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24383:SF14">
        <property type="entry name" value="ZINC FINGER PROTEIN 579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="329"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="513"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035305279.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="61200" checksum="CED4380233920800" modified="2023-06-28" version="1">MDPQPPPPAQGSPPHRGRGRGRGRGRGRGRGRGRGGTGAPRAPLPCPTCGRLFRFPYYLSRHRLSHSGLRPHACPLCPKAFRRPAHLSRHLRGHGPQPPLRCAACPRTFPEPAQLRRHLAQEHAGGEVDVSTQRAVKEEPEASWGPQDEGVEQPSTAAAGGAEEVVAAAAAAAAEWPETWPSGDPAPLAAPTSTDPRESEAKEAEAGAAELRAELALAAGRQEEKQVLLQADWTLLCLRCREAFATKGELKAHPCLRPEGEQEGEGGPPPRPKRHQCSICLKAFARPWSLSRHRLVHSTDRPFVCPDCGLAFRLASYLRQHRRVHGPLSLLAPLPGAGKKDDKSSGGRNSGRGPEGGEGAECGGASEGGEGGQNGGDATPARPPAGEPRFWCPECGKGFRRRAHLRQHGVTHSGARPFQCVRCQREFKRLADLARHAQVHAGGPAPHPCPRCPRRFSRAYSLLRHQRCHRAELERAELERATALQALQSQAAQSPQTPLKQETEGLPLSIAHIKEEPPSPGTPPQSPRAPPVFLSASCFDSQDHSAFEMEDEEVDSKAHLRGLGGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H988</accession>
    <name>A0A9J7H988_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 420-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113838744</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305011.1">
        <property type="nucleotide sequence ID" value="XM_035449120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H988"/>
    <dbReference type="GeneID" id="113838744"/>
    <dbReference type="KEGG" id="cge:113838744"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001933">
        <property type="entry name" value="Zinc finger protein 870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035305011.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40417" checksum="66D2A573E4E488E0" modified="2023-06-28" version="1">MKGSTLKVHQRTCIGMKLYRYKECGKSFTTGSDLKVHQRIHTGKKQYICNKCGKYFMKGSDLKIHQRIHVGEKTYKCKECGKCFTQGSNLQVHHRIHTGEKPYKCTECGKSFSNGSGLKVHQRIHTGEKPYKCKECGKSFTQGSSLQVHQRIHTGEKPYKCKECGKSYKHGSSLQVHQRIHTGEKSYKCNECGKCFMNGSNLHSHQRIHTGEKPYKCKECGKSFTQGSTLHVHQRIHTGEKTYKCNECGKCFMNSSNLHSHQRIHTGEKPYKCKECGKSFTQGSTLHVHQRTHTGEKPYKCNDCGKCFMKGSNLHSHQRIHTGERPYKCKECGNSFTKGSTLQVHQRIHTGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HAI8</accession>
    <name>A0A9J7HAI8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1</fullName>
            <ecNumber evidence="6">2.7.1.25</ecNumber>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Sulfurylase kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC100762413</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="6"/>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="RefSeq" id="XP_035306431.1">
        <property type="nucleotide sequence ID" value="XM_035450540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HAI8"/>
    <dbReference type="GeneID" id="100762413"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000001">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000243">
        <property type="entry name" value="Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000006">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF17">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="19">
        <location>
            <begin position="51"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="21">
        <location>
            <begin position="233"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="20">
        <location>
            <begin position="394"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035306431.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="70788" checksum="82B966B4EE630AB4" modified="2023-06-28" version="1">MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAEALPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRIYWNDGLDQYRLTPAELKQRFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPTHGAKVLTMAPGLITLEIVPFRVAAYNKKKQRMDYYDSEHHLKQSSTQEHRGLKILDPVCVMSVCVAVLEKRRSTQGSVSTGGDSAFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HBR4</accession>
    <name>A0A9J7HBR4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox protein NOBOX isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Nobox</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035307296.1">
        <property type="nucleotide sequence ID" value="XM_035451405.1"/>
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    <dbReference type="GeneID" id="100756744"/>
    <dbReference type="KEGG" id="cge:100756744"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NOBOX oogenesis homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX PROTEIN NOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47060:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN NOBOX"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="181"/>
            <end position="241"/>
        </location>
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    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="183"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
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        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035307296.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="61798" checksum="05B22C174D09757F" modified="2023-06-28" version="1">MALPAPHPRCAVPRPGGGVGGTGSCCARPGLGKLHTPGHSTDFIKCHWLLLSTGQEARAKPRTAGMESEGPLKDSTLPAKDDQGKQSSFRRAGSEKRPLSKTSGELMGADTCRGCLDKDPAPAACSPQPEEDLSSLPERKVKRARTSISAVLGKHRNPNTMGLVLTSQAEDLKESREVTCPFQKKTRTLYRSDQLEELERIFQEDHYPDSDKRREIAQMLGVTSQRIMVWFQNRRAKWRKVEKLSEKGNRDGPAAPSADGSQHRSVPELLPPTPADLDPGPVPPEHILDGFPESHMLLTSDQTLAPSQHSEGVQRVAVTPPLFSPPPLQRTNLPLPIDPIQPPQVMPPLRDVPGSNSIHKDSPCGSWGTSITSSSACSTLEYLGPQDYPASSQLGSFPFSQAPQTPLFPPFQSQFPYLPPFLLPTPSFLPPEDSLFSFPFGLSGDSSQDYCPGLSPGQHWLQPHVGNMGPGPWGGHCLPEPPFLGPQYPHTLGHPLGIEGYFPDLLPAPCAQTMSKQPSLGLNGLPKGTKGPETVSSLSKMPGEQIASSLEQPAPEEVKDKTKSNHATGTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HEL0</accession>
    <name>A0A9J7HEL0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette sub-family G member 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100764293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035308952.1">
        <property type="nucleotide sequence ID" value="XM_035453061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HEL0"/>
    <dbReference type="GeneID" id="100764293"/>
    <dbReference type="KEGG" id="cge:100764293"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF70">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="37"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035308952.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="75287" checksum="99EA83766D85CD7E" modified="2023-06-28" version="1">MSSNNDPVVIPMIERISSDLPVMDTRDPETLTGEAVLSFHNISYGETVQSGFPFCKETCVIERLSNISGIMKPGLNAIMGPQDGSRSLLLDVLAARKDPRGLTGDILINGKPRPANFKCTSGYVPQNDMVMHTVSVRENVEFSAALRLPTSITRDEKRSRINEVLGLLHLDEESNVKPRSKELRKRTSIAMELVIEHPILFLDDPTTDLDLGTTTDVISVLKKMSMRGRTIIFSINQPPYFIFRCFDSLTLVASGKVMFHGPAQEALEYFTSAGYNYDSHLNPVDFFLDIINGGFSAILDTEEGGQKADKYKEISERQHQVTEKLAHMYAQSFLYRVMRIELDLLLGEQKAKRSSALEEITCVTPFWHQLWWITSRSFTSFQCFSWVIMIQAIFLVMFAVFVGTIFNFLPDDCSEVNRRVGLLFSLTVFQCIISMTPWEHFVIDRDRFLHEHTSGYYKVASYFFGKLLAELLPRRLLPSIIFTAIVFSIAGIITDAKGFLTTLFTIMMLAYSASSLPLSIGAGKNPVAVPTLLMMIYFGLMLLFLVLDLYSGSLLPVLSLIQYISIPHYGFTALLHNEFLGQNFCPEHKAAEINRSQNYVICTGEEFLTIQGIDLSPWGFWQNHVALSCIIIIFLSITYLQLIPQKKVEVLRSGWRKFQQLFKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J6K0</accession>
    <name>A0A9J7J6K0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRAME family member 9/15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100753671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027246062.1"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109212" checksum="D51022516CECAD4B" modified="2023-06-28" version="1">MCLARGSFRAGSSSPGIHEGLPAASESVTMDASSHDKQPSEARECVVNNSGNASFILGTGKSVTPQKRVEDATPNLCTPVTVKSPLNFSTITVEQLGITPESFVKTPSGKSASLQKTRRRSTVGVRGSPETNCLIRFIAQQRSLKNAARSLLTQNSPFQGSPGLYRHASALKERMAAFRSAFHSVQETEKMAGGPAASKADGESKTSNLTKKEGLVEYQQSGFPLNSSSKRRRISSQNSPDDHLSSAKGKVVCGQMLADQSCAIGTSADLAEKSSDIGPAQPGCLVAPCPELMETSHGLGVADCVEDTQSVVAVPLDTPEAQVNADTAPAIRSSPVFGSSTPSKTFVLRSVLKKPGKLFAENGKECILYDSGSHLIPDPSNCKEQRAGRENCKTPGFLNLKKRKRVTFGEDLSPEVFDESLPANTPLCKGGTPVRQRNLNAASPLQSPVHEQLLQPNFDDSEENLENIEPTQIPIAILSPSKSSFSETLPGIDTCSSLGNLEQISYNVGRPTRISHRRKQVMSSAGGVVCNSYTTEAEPCKEKNMNRRTSQEKKCISNALPGKKQVLKSYRKKKRRGKKSVEKSLYGERDMASKKPLLSPIPELPEVSEMTPLADCTQKICSDDFNVSDKQEEVISLEIPAKRKRLLTQEEDLPEFDPAFDQSLVSELCCCVLPVTAASVGGPNANAGDTGRAGNSSTKIKHQSANEPKTETKTENSPMPCASVTREHVVSDNPKPLCIPWCQEFSETDKENPCEVLTVSENMNMKCEEESACPAPKGNLQCDPVTSDSDRGGNCSEDVLVENLKETTSHSETVGRKCSENGSLMSGRERKRRRLSMLCCEGQSSYLEQKGDSTSSNSGGSSVEISLRNPQLCEDLSDAIEQSFQRTNTKLKVRRSTRLQGNLDSTGLIWILPPTPPTSQKTKRRMTICAFDSRRLQSMSSREDTVSSGQTPNPLPSIPGSGCQGIGSSKLPGKRRKSCVYTLPNAESTTEPPHFKRIPSLKKGESSQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J9F9</accession>
    <name>A0A9J7J9F9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UL16-binding protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100772312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027256790.1">
        <property type="nucleotide sequence ID" value="XM_027400989.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J9F9"/>
    <dbReference type="GeneID" id="100772312"/>
    <dbReference type="KEGG" id="cge:100772312"/>
    <dbReference type="OrthoDB" id="9836934at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002486">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002476">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF268">
        <property type="entry name" value="UL16-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039952934" evidence="3">
        <location>
            <begin position="30"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027256790.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28362" checksum="BEBB29B189AF5199" modified="2023-06-28" version="1">MAKKAAAERMALCFSVLLICLWSVLLNDAASLCYIFTVGKSGSGPWRHKVQGQLNKETFLSYISIDNCHVFGVLGSRLNATKICEKQNDILNDGVNLIKQQASHINNIIREALTVQAEMCCWNEEDGHLNASWDIDLNGHKILHFDSSTGKLTEVGPGSSRIKELLKEDRHVTAFLTVTSQGDCRSWLQEVTLHLGKKLQPTASPTATPHVDQPPSSLAIKPNISVLLIILPYTLLCFLRGILDNDREKMLQRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JAJ1</accession>
    <name>A0A9J7JAJ1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable hydrolase PNKD isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100751315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_016836431.1">
        <property type="nucleotide sequence ID" value="XM_016980942.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253010.1">
        <property type="nucleotide sequence ID" value="XM_027397209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JAJ1"/>
    <dbReference type="GeneID" id="100751315"/>
    <dbReference type="KEGG" id="cge:100751315"/>
    <dbReference type="OrthoDB" id="6706212at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027253010.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15552" checksum="4ABB78D8F1A0DBDF" modified="2023-06-28" version="1">MAAVVAATALKGRGARNARVLRGILSGATANKASQNRTRALQSHSSPECKEEPEPLSPELEYIPRKRGKNPMKAVGLAWAIGFPCGILFFVLTKQEVDKNRLKQMKARQNMRVSNTGEYESQRFRASSQQAQVPEVGSGVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JKW5</accession>
    <name>A0A9J7JKW5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">Ppp6r3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4 5 6">17A/GY</strain>
            <tissue evidence="4 5 6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007649185.1">
        <property type="nucleotide sequence ID" value="XM_007650995.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016835125.1">
        <property type="nucleotide sequence ID" value="XM_016979636.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264572.1">
        <property type="nucleotide sequence ID" value="XM_027408771.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264573.1">
        <property type="nucleotide sequence ID" value="XM_027408772.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264574.1">
        <property type="nucleotide sequence ID" value="XM_027408773.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JKW5"/>
    <dbReference type="GeneID" id="100761104"/>
    <dbReference type="KEGG" id="cge:100761104"/>
    <dbReference type="CTD" id="55291"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF12">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027264572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027264573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027264574.1"/>
        </source>
    </evidence>
    <sequence length="889" mass="99663" checksum="48C6376A8C5DC8BA" modified="2023-06-28" version="1">MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVSQMNDRLGEDESLLLKLYSFLLNESPLNPLLASFFSKVLSILISRKPEQIVDFLKKKRDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQDVLNWLNEERIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQVQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQILLTLLETRRPTFEGHIEICPPGMGHSACSVNKSVLEAIRGRLGSFHELLLEPPKKSVMKTTWGILDPPVGNTRLNVIRLISSLLQTNTSSINGDLMELNSIGVILDMFFKYTWNNFLHTQVEICIALILASPFENAENGTITDQDSAGDNLLLKHLFQKCQLIERILEAWDTNEKKQAEGGRRHGYMGHLTRIANCIVHSTDKGPNSVLVQQLIKDLPDEVRERWETFCTSSLGETNKRNTVDLVTTCHIHSSSDDEIDFKDTGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFESSSANTEDKMEVDLNEPPTWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPAKETGWASFSEFTSSLSTKESLRSNSPVEMETSTEPVDPLTPGAAALAPQPEAPGSVAMEASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKSEEEKLSTSQDAACKDVEESPEPAEAKCAAPRTPSSSPEQSHLLLRLSQWSEGIGQAKASAAEGPRPYTRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JKW6</accession>
    <name>A0A9J7JKW6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LOW QUALITY PROTEIN: igE-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC113836300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027276319.2">
        <property type="nucleotide sequence ID" value="XM_027420518.2"/>
    </dbReference>
    <dbReference type="GeneID" id="113836300"/>
    <dbReference type="KEGG" id="cge:113836300"/>
    <dbReference type="OrthoDB" id="9630350at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045345">
        <property type="entry name" value="Gag_p24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050195">
        <property type="entry name" value="Primate_lentivir_Gag_pol-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008916">
        <property type="entry name" value="Retrov_capsid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40389">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40389:SF3">
        <property type="entry name" value="IGE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00607">
        <property type="entry name" value="Gag_p24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19317">
        <property type="entry name" value="Gag_p24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14787">
        <property type="entry name" value="zf-CCHC_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027276319.2"/>
        </source>
    </evidence>
    <sequence length="446" mass="49967" checksum="336276D213F90D81" modified="2023-06-28" version="1">MWSDELQPVRGSDDSESSGDEVLDTEEEAEQDEEADKYEEERYHPDDHIQSSKKPRRRQLQTALSQVVPSAPPPYETHPKSYSFLPEKVKRKLRLAFPVFEGIEGEQMHAPVEYNQIKELAESVRKYGGTANFTLAQLDRLALNALTPSDWQMVAKAALVSMGQYMEWKALWHEAVQEQARANATALTPEQQLWTFNLLTGQGRFAADQTNCHWGAYPQIANAAIRAWKALSERRGGVDNQLTKIIQGTQEPFSDFVARMTEAVGRIFGDPEQAAPLVEQLIFEQATQECRTAIAPRKNKGLQDWLRVCRELGGPLTNAGLAAAILQSQKHPLXGPDKRTCFRCGKAGHLRKDCKMPDRERGPPTLCTRCGKGYNKAYQCRSVRDIKGRILPPIETTINEVPKNGAAGPQSQGPPKYGNRFTRVTDGTPPPESEQEWTCEPPPTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JM97</accession>
    <name>A0A9J7JM97_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Ebner gland protein 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113830841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027278533.1">
        <property type="nucleotide sequence ID" value="XM_027422732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JM97"/>
    <dbReference type="GeneID" id="113830841"/>
    <dbReference type="KEGG" id="cge:113830841"/>
    <dbReference type="OrthoDB" id="9565930at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF124">
        <property type="entry name" value="LIPOCALIN 1-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039890009" evidence="2">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027278533.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20799" checksum="75CB2E077E7F7267" modified="2023-06-28" version="1">MEAMQLFLLTIGLTLFSLVQAGYINRGECATTDKLLGNWYIICWAGNLPLPEEKLRSPLPPFTFTKNKIGYLEFKMNISKPIGCVEFKIALNEAKDKPCYFSAWMWHYIGIVLFEGDNFGIAYLNAKVDDTYQKMAMLMGRRNHTASLTMLKDFETVVIQLSLNKTSIITPPYDDSCELGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JN87</accession>
    <name>A0A9J7JN87_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ubiquitin carboxyl-terminal hydrolase 28</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Deubiquitinating enzyme 28</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ubiquitin thioesterase 28</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin-specific-processing protease 28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Usp28</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBXW7) complex. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with ZNF304. Interacts with PRKD1. Interacts with TP53BP1. Interacts with FBXW7; following DNA damage, dissociates from FBXW7 leading to degradation of MYC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the peptidase C19 family. USP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027267895.1">
        <property type="nucleotide sequence ID" value="XM_027412094.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JN87"/>
    <dbReference type="GeneID" id="100756704"/>
    <dbReference type="KEGG" id="cge:100756704"/>
    <dbReference type="CTD" id="57646"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02665">
        <property type="entry name" value="Peptidase_C19I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14355">
        <property type="entry name" value="UBA_UBP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20487">
        <property type="entry name" value="USP28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000004">
        <property type="entry name" value="Putative ubiquitin carboxyl-terminal hydrolase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000046">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 28 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054108">
        <property type="entry name" value="USP25/28_UIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF678">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21909">
        <property type="entry name" value="USP_UIM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="23">
        <location>
            <begin position="162"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="483"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="701"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="773"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="784"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00075171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027267895.1"/>
        </source>
    </evidence>
    <sequence length="1143" mass="129287" checksum="1FCAF16379AA2E3B" modified="2023-06-28" version="1">MTAELQQDDAAGATDGHGSSCQMLLNQLREITGIQDPSFLHEALKASNGDITQAVSLLTDQRVKEPSYDTTATEPSEDEGSAANKELLAKVIDLTHDNKDDLQAAIALSLLESPKIQTDGRDLNRMHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQELQYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSNPRNKSENPMVQLFYGTFLTEGIREGKPFCNNETFGQYPLQVNGYRNLDECLEGAMVEGDIALLPSDHSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYKSKELIRSKRESIRKLKEEIQILQQKLERYVKYGSGPARFPLPDMLKYVIEFASTKPASESCLSRSAEHMTLPLPSVHCPVSDLTSKESPESCSQDAEGTFSSPEDALPKSDVMNGPCSSPHSSLGVSAPPAPRTVTDEEMNSVKTCLQRWRSEIEQDIQDLKNCIESTTQAIEQMYCDPLLHQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQIWLKYNDISVTESSWEELERDSYGGLRNVSAYCLMYINDKLPHFNAEAAANESDQMAGEVEALSVELRQYIQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESPAASSHGVRCLSSEHAVIAKEQTAQAIANTAHAYEKSGVEAALSELKEAEPEKPKSQETILAEQSEQTPEASDTEAAAPPNPEVSEVEIPSVGRILVRSDADGYDEEVMLSPAMQGVILAIAKARQTFDRDGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQFADRNLSYDERSISIMKVAQAKLMEIGPDDMNMEEYKRWHEDYSLFRKVSVYLLTGLELFQKGKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JR80</accession>
    <name>A0A9J7JR80_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sarcoplasmic reticulum histidine-rich calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Hrc</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K055</accession>
    <name>A0A9J7K055_CRIGR</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="14" type="primary">LOC113838484</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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            <taxon>Mammalia</taxon>
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        </source>
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        <property type="project" value="UniProtKB-SubCell"/>
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            <dbReference type="RefSeq" id="XP_027289953.2"/>
        </source>
    </evidence>
    <sequence length="468" mass="52262" checksum="C9F6D285DF10F76E" modified="2023-06-28" version="1">MTVSFTALLCLGLTLGHGIPVLAGTFFPKPILRVQPDSVVSEQTTVTFLCEGTLKAQEYRLYKNGHQYTMHTDITSNPKNKVEFSISKIGHQEAGNYTCRYRTLEGWSEYSDTLQLVVTGAFNKPRLSALPSPVVTEGGNVTLQCVSNQGYYGFILTKEGPQKQSWTTHSKYNYSTSQYHACISVGPVTSNQRWTFRCYSFESYSRLLWSKPSDPLELLVSGILHKPTIKAEPGPVVTLGSPMNISCQGTLNAELYFLHKEGRQQIWGTQTPKEPGKKSTFSIPSVTQSHIGQYRCYCYTSAGWSERSDTLELVVTGIYENKPSLTALPSPVVTSGGSMTLQCVSRVFYHKFILTKEDQKFSSSLNSQYIHSTMQYQALFSIDHVTADHRGTFRCYGYYNLTPQLWSAPSEPLEIHISATASENKDYTVENLIRVGMAALVLIFLGILVFEPWGSQTEAHHAAENHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3S1</accession>
    <name>A0A9J7K3S1_CRIGR</name>
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        <recommendedName>
            <fullName evidence="13">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
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        <name evidence="15" type="primary">LOC113839120</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
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            <taxon>Muroidea</taxon>
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        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
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        <text evidence="1">Putative pheromone receptor.</text>
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        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:pheromone receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027290371.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37791" checksum="7A917A6E26D1FDA1" modified="2023-06-28" version="1">MYFWALTLKIIFLSLTAIGILGNFSVFYYYLFCYGDCKLKAVDLIHWHLMAANTLIILSKGVPHTMAAFGLKQFLNDIQCRLILYIERVGRGVSIASTCLLSVFQVISISHKKSCCKDQKFKAANYIGCCLSLLWVSCTLIHFIFFVYPIIKRYSINVTSKRDFGHCSTVGRDGINDSLYVALVACPEIFFSLLMAWSSCSMIVILHRHKKRVQHIRSTHGSIRTSPESRVTQNILVLVSNFLAFYTLSSVLQGCVALLSNPSWWLVNITHLVSLCFPCFGPCVLMNRYSIMPSLSLVWIRNVTTLILKYVNDIILMVSSCLVTHLPHKVSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4Q3</accession>
    <name>A0A9J7K4Q3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC100761462</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309262.1">
        <property type="nucleotide sequence ID" value="XM_035453371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K4Q3"/>
    <dbReference type="GeneID" id="100761462"/>
    <dbReference type="KEGG" id="cge:100761462"/>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000032">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF1">
        <property type="entry name" value="SODIUM LEAK CHANNEL NALCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="25">
        <location>
            <begin position="245"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="25">
        <location>
            <begin position="567"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="969"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="971"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="991"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_035309262.1"/>
        </source>
    </evidence>
    <sequence length="1096" mass="126225" checksum="C7B6BB772C81A099" modified="2023-06-28" version="1">MVKISKLPSDFTVPKIRESFMKQFIDRQQQDTCCLFRILPSTSSSSCDNPKRPTVEDNKYIDQKLRKSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMITVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPSEDTNANSQDHNTQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKPLSHSVSSVNLRFGGRTAMKSVVCKMNPMPDTASCGSEVKKWWTRQLTVESDESGDDLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K665</accession>
    <name>A0A9J7K665_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat and SOCS box-containing protein 2 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Wsb2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
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    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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            <begin position="126"/>
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    </evidence>
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        <source>
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        </source>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
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            <strain evidence="4">17A/GY</strain>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="659" mass="71350" checksum="FB9BB6E527DC9EAC" modified="2023-06-28" version="1">MKMHAEKKHTCSKCSNSYGTEWDLKRHEEDCGKTFQCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPGKKKKNGKLCKARSCSESLSDQPAPHQDIHELEASEVKLAASFEDSFHTHAKKQNITAPPRCPQKLLLPKPKVALVKLPVMQFSPVPIFMPTADPSVQPVVLGVDRGSAAGAVHLVPLSVGTLVLSLDSQACSMKESLPLSKIISPIVEPISTSVXGKSPCGPLQELGNTCQKNSISPINVQTDLSYTSPYLIPSAQWLSPDSSXSSCSQTDLSFDSQVSLPVSVHTQTLVPSSKVTLSIAARTDAFIDACFQPGGISRETQTSRMRDPTDDPVQVGHTGLCGDIFEGVHSSYSVTSDNIMSSSLVSETVTNGLLPQNDHKILSQVIEKPAPLLYFSAQNSMLPSQNMTDNQTQTIDLLSHLENILSSNLPGQALDNWSLLSDANPGPDAQLPSASGQNSGIDFDIEEFLSASNIQTQTEESELSGVSTEPALESLDIETQTDFFLTDPSAQSYGFRGSSSFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHFSFSMSTDYSDTETQTEGASPSRHTPALESKVHLNSTETQTMSSGFEPLGNLFFTSNETQTAMGDFLLADLAWNTMESQFSSVETQTCSELHAVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KDW0</accession>
    <name>A0A9J7KDW0_CRIGR</name>
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        <submittedName>
            <fullName evidence="7">Non-histone chromosomal protein HMG-17-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC103160456</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306510.1">
        <property type="nucleotide sequence ID" value="XM_035450619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KDW0"/>
    <dbReference type="GeneID" id="103160456"/>
    <dbReference type="KEGG" id="cge:103160456"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000079">
        <property type="entry name" value="HMGN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087:SF11">
        <property type="entry name" value="HIGH MOBILITY GROUP NUCLEOSOMAL BINDING DOMAIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087">
        <property type="entry name" value="NONHISTONE CHROMOSOMAL PROTEIN HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01101">
        <property type="entry name" value="HMG14_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00925">
        <property type="entry name" value="NONHISHMG17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00527">
        <property type="entry name" value="HMG17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035306510.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16592" checksum="A38F6A642EA4DC0B" modified="2023-06-28" version="1">MARGETEAMQDEPENGKYWKLQGELARQLRAKIFSDVLPLCLPENAELVTTTSRSSAPTSSTTDTPKRKAEADTKGDKAKMKDEPQRKSARLSAKPAPPKPEPKPEKAPAKKREKVPKGKKGKADAGKDANSPAENKDTKIGQAQKAEGAGDAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A2V7M9</accession>
    <name>PGAP3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI-specific phospholipase A2-like PGAP3</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>PER1-like domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Post-GPI attachment to proteins factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PGAP3</name>
        <name type="synonym">PERLD1</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Mol. Biol. Cell" volume="18" first="1497" last="1506">
            <title>Fatty acid remodeling of GPI-anchored proteins is required for their raft association.</title>
            <authorList>
                <person name="Maeda Y."/>
                <person name="Tashima Y."/>
                <person name="Houjou T."/>
                <person name="Fujita M."/>
                <person name="Yoko-o T."/>
                <person name="Jigami Y."/>
                <person name="Taguchi R."/>
                <person name="Kinoshita T."/>
            </authorList>
            <dbReference type="PubMed" id="17314402"/>
            <dbReference type="DOI" id="10.1091/mbc.E06-10-0885"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 4">Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain (PubMed:17314402). May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate (Probable). The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts (PubMed:17314402).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-C-terminal carboxyl phosphoethanolamide-GPI(deacylinositol-H7) + H2O = [protein]-C-terminal carboxyl phosphoethanolamide-lysoGPI(deacylinositol-H7) + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83847"/>
            <dbReference type="Rhea" id="RHEA-COMP:20211"/>
            <dbReference type="Rhea" id="RHEA-COMP:20230"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:233273"/>
            <dbReference type="ChEBI" id="CHEBI:233420"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:83848"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AB288236">
        <property type="protein sequence ID" value="BAF47369.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233642.1">
        <property type="nucleotide sequence ID" value="NM_001246713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A2V7M9"/>
    <dbReference type="GlyCosmos" id="A2V7M9">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-NP_001233642.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00000024014">
        <property type="protein sequence ID" value="ENSCGRP00000023688"/>
        <property type="gene ID" value="ENSCGRG00000017161"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001029015">
        <property type="protein sequence ID" value="ENSCGRP00001024769"/>
        <property type="gene ID" value="ENSCGRG00001022580"/>
    </dbReference>
    <dbReference type="GeneID" id="100689454"/>
    <dbReference type="KEGG" id="cge:100689454"/>
    <dbReference type="CTD" id="93210"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DFMIEDC"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000339355" description="GPI-specific phospholipase A2-like PGAP3">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="280"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="17314402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="17314402"/>
        </source>
    </evidence>
    <sequence length="320" mass="36824" checksum="2F53116C7662B1AD" modified="2007-03-20" version="1" precursor="true">MAERTARLLLLTVTVGLAWGSQGDREPVYRDCVLRCEERNCSGDALKHFRSLQPIYMSLAGWTCRDDCKYECMWITVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSIYLCCVRTVGLQHPSVARAFGATLLLMLLLHTSYLSLVRFDYSYNMMANVAIGLVNLAWWLAWCLRNHRRLPHTRKCVAVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFRFLEDDSLYLLKESEAKFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYG2</accession>
    <name>G3GYG2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Syntaxin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">Stx19</name>
        <name evidence="14" type="ORF">H671_4g13400</name>
        <name evidence="13" type="ORF">I79_002838</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with EGFR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000066">
        <property type="protein sequence ID" value="EGV94998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE676022">
        <property type="protein sequence ID" value="ERE74484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295819.1">
        <property type="nucleotide sequence ID" value="XM_035439928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300297.1">
        <property type="nucleotide sequence ID" value="XM_035444406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYG2"/>
    <dbReference type="STRING" id="10029.G3GYG2"/>
    <dbReference type="PaxDb" id="10029-XP_007628506.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002346.1">
        <property type="protein sequence ID" value="ENSCGRP00001001920.1"/>
        <property type="gene ID" value="ENSCGRG00001001896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768974"/>
    <dbReference type="KEGG" id="cge:100768974"/>
    <dbReference type="CTD" id="415117"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244948"/>
    <dbReference type="OMA" id="CKAICCW"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000022">
        <property type="entry name" value="Syntaxin 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000017">
        <property type="entry name" value="Syntaxin 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF29">
        <property type="entry name" value="SYNTAXIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV94998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE74484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035300297.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33707" checksum="2471AA362B6350F1" modified="2011-11-16" version="1">MKDRLQELKQKTKEIELSRDSQVFAEADDQGVLVQQAVIYEREPVAERHLHEIQKLQETINSFADDVQKFGQQQKSLVASMRRFSLLKRDSTIAKEIKIQAEQIHRALGDLVKEVKKSEVENGPSSVVTRILKSQYAAMFHHFQQTMFLYNDTIASKQEKCKTFIVRQLEVAGKEVSEEEVNDMLHHGKWEVFNESLLTETSITKAQLSEIEQRHKELVNLETQVKDLRDLFIQISLLVEEQGESLNNIEVMVTSTKDYVINTKEKFGLAVKYKRRNPCRVLCCCCPCCGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYI9</accession>
    <name>G3GYI9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18 19 20" type="primary">Harbi1</name>
        <name evidence="14" type="ORF">I79_002868</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19 20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19 20">17A/GY</strain>
            <tissue evidence="18 19 20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000067">
        <property type="protein sequence ID" value="EGW03929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497342.1">
        <property type="nucleotide sequence ID" value="XM_003497294.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007608206.1">
        <property type="nucleotide sequence ID" value="XM_007610016.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016820701.1">
        <property type="nucleotide sequence ID" value="XM_016965212.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278318.1">
        <property type="nucleotide sequence ID" value="XM_027422517.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278319.1">
        <property type="nucleotide sequence ID" value="XM_027422518.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278320.1">
        <property type="nucleotide sequence ID" value="XM_027422519.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYI9"/>
    <dbReference type="STRING" id="10029.G3GYI9"/>
    <dbReference type="PaxDb" id="10029-XP_007629068.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027164.1">
        <property type="protein sequence ID" value="ENSCGRP00001022919.1"/>
        <property type="gene ID" value="ENSCGRG00001021313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753396"/>
    <dbReference type="KEGG" id="cge:100753396"/>
    <dbReference type="CTD" id="283254"/>
    <dbReference type="eggNOG" id="KOG4585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEPNCKV"/>
    <dbReference type="OrthoDB" id="10062286at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF253">
        <property type="entry name" value="NUCLEASE HARBI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="148"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW03929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027278318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027278319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027278320.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38837" checksum="5A8EE6A36852A508" modified="2011-11-16" version="1">MAVPITVLDCDLLLYGRGHRTLDRFKLDDVTDEYLMSMYGFPRQFIYYLVELLGASLSRPTQRSRAISPETQILAALGFYTSGSFQTRMGDAIGISQASMSRCVAHVTEALVERASQFIHFPADEAAVQSLKDEFYGLAGMPGVIGVVDCIHVAIKAPNAEDLSYVNRKGLHSLNCLIVCDIRGALMTVETSWPGSLQDCAVLQQSSLSSQFETGMHKDSWLLGDSSFFLRTWLMTPLHIAETPAEYRYNRAHSATHSVIEKTLRTLCSRFRCLDGSKGALQYSPEKSSHIILACCVLHNISLEHGMDVWSSPGTGPIEQPPEGEYEQMESLDLEADRIRQELMLTHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G3H2H8</accession>
    <name>G3H2H8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 23" type="primary">Timm8b</name>
        <name evidence="18" type="ORF">H671_4g12051</name>
        <name evidence="17" type="ORF">I79_004391</name>
    </gene>
    <organism evidence="17 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000115">
        <property type="protein sequence ID" value="EGW03820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE674738">
        <property type="protein sequence ID" value="ERE76165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498582.1">
        <property type="nucleotide sequence ID" value="XM_003498534.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267944.1">
        <property type="nucleotide sequence ID" value="XM_027412143.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H2H8"/>
    <dbReference type="STRING" id="10029.G3H2H8"/>
    <dbReference type="PaxDb" id="10029-XP_007619112.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021439.1">
        <property type="protein sequence ID" value="ENSCGRP00001017195.1"/>
        <property type="gene ID" value="ENSCGRG00001017302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774369"/>
    <dbReference type="KEGG" id="cge:100774369"/>
    <dbReference type="CTD" id="26521"/>
    <dbReference type="eggNOG" id="KOG3489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155479"/>
    <dbReference type="OMA" id="NEICWDK"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000005">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim8 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW03820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ERE76165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027267944.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9314" checksum="9DC47BA531DB8692" modified="2011-11-16" version="1">MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITGRFAQIVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3HEV8</accession>
    <name>G3HEV8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc transporter 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Solute carrier family 30 member 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Slc30a6</name>
        <name evidence="18" type="ORF">I79_009105</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer with SLC30A5; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000321">
        <property type="protein sequence ID" value="EGW02706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502536.1">
        <property type="nucleotide sequence ID" value="XM_003502488.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281893.1">
        <property type="nucleotide sequence ID" value="XM_027426092.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HEV8"/>
    <dbReference type="STRING" id="10029.G3HEV8"/>
    <dbReference type="GlyGen" id="G3HEV8">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007633043.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020486.1">
        <property type="protein sequence ID" value="ENSCGRP00001016242.1"/>
        <property type="gene ID" value="ENSCGRG00001016614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763102"/>
    <dbReference type="KEGG" id="cge:100763102"/>
    <dbReference type="CTD" id="55676"/>
    <dbReference type="eggNOG" id="KOG1484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WITIFAC"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071579">
        <property type="term" value="P:regulation of zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000009">
        <property type="entry name" value="zinc transporter 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052005">
        <property type="entry name" value="CDF_SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531:SF1">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="17">
        <location>
            <begin position="35"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGW02706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027281893.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="50818" checksum="D3FB049A777C4076" modified="2011-11-16" version="1">MGTIHLFRKPQRSFFGKLLQEFRLVAADRRSWKILLFGAVNVLCTGFLLMWCSSTNSIALTAYTYLTIFDLFSLITCLISYWVMMRKPSPAYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLDQPEIHTGRLLVGTFVALSFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLSRSVCGIIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKDDWIRPALLSGPVASNALNFSDHHIIPMPLLKNVDDRIPVTSTPAKPSSPPPEFSFNTPGKNVSPVILLNTQTRPYGLGLSRGHTPYSSVLGQGLAVPGVGAGQGLRPTFPHVPSRYGNNRTGQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3HLJ9</accession>
    <name>G3HLJ9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 11">60S ribosomal protein L36a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">LOC100754891</name>
        <name evidence="7" type="synonym">LOC107979412</name>
        <name evidence="6" type="ORF">I79_011589</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000492">
        <property type="protein sequence ID" value="EGW08178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504543.1">
        <property type="nucleotide sequence ID" value="XM_003504495.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283506.1">
        <property type="nucleotide sequence ID" value="XM_027427705.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HLJ9"/>
    <dbReference type="SMR" id="G3HLJ9"/>
    <dbReference type="STRING" id="10029.G3HLJ9"/>
    <dbReference type="PaxDb" id="10029-XP_007610388.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013375.1">
        <property type="protein sequence ID" value="ENSCGRP00001009190.1"/>
        <property type="gene ID" value="ENSCGRG00001011332.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001015002.1">
        <property type="protein sequence ID" value="ENSCGRP00001010777.1"/>
        <property type="gene ID" value="ENSCGRG00001012586.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001027563.1">
        <property type="protein sequence ID" value="ENSCGRP00001023317.1"/>
        <property type="gene ID" value="ENSCGRG00001021589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754891"/>
    <dbReference type="KEGG" id="cge:100754891"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGW08178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027283506.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12441" checksum="AE3308265D70BD26" modified="2011-11-16" version="1">MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3HM25</accession>
    <name>G3HM25_CRIGR</name>
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        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Atp6v1g3</name>
        <name evidence="8" type="ORF">I79_011770</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000500">
        <property type="protein sequence ID" value="EGW10923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504724.1">
        <property type="nucleotide sequence ID" value="XM_003504676.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273907.1">
        <property type="nucleotide sequence ID" value="XM_027418106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HM25"/>
    <dbReference type="STRING" id="10029.G3HM25"/>
    <dbReference type="PaxDb" id="10029-XP_007633961.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017811.1">
        <property type="protein sequence ID" value="ENSCGRP00001013574.1"/>
        <property type="gene ID" value="ENSCGRG00001014674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763970"/>
    <dbReference type="KEGG" id="cge:100763970"/>
    <dbReference type="CTD" id="127124"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160882"/>
    <dbReference type="OMA" id="SYHRNME"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF5">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW10923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027273907.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13863" checksum="2A715AB0CCDE7322" modified="2011-11-16" version="1">MTSQSQGIQQLLQAEKRAKDKLEEAKKRKGKRLKQAKEEAMAETDQYRMQREKEFHLKQSKMMGSQSHLSDEIEEQTLEKIKELNRSYNNCMESVIKQLLSMVCDLKAEVHVNYRATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3HQC8</accession>
    <name>G3HQC8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTG anti-proliferation factor 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4 8">Protein BTG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Btg2</name>
        <name evidence="4" type="ORF">I79_013025</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000605">
        <property type="protein sequence ID" value="EGW02253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505804.1">
        <property type="nucleotide sequence ID" value="XM_003505756.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273372.2">
        <property type="nucleotide sequence ID" value="XM_027417571.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HQC8"/>
    <dbReference type="SMR" id="G3HQC8"/>
    <dbReference type="STRING" id="10029.G3HQC8"/>
    <dbReference type="PaxDb" id="10029-XP_007633909.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023470.1">
        <property type="protein sequence ID" value="ENSCGRP00001019226.1"/>
        <property type="gene ID" value="ENSCGRG00001018732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766229"/>
    <dbReference type="KEGG" id="cge:100766229"/>
    <dbReference type="CTD" id="7832"/>
    <dbReference type="eggNOG" id="KOG4006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKNQIML"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021954">
        <property type="term" value="P:central nervous system neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021542">
        <property type="term" value="P:dentate gyrus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007406">
        <property type="term" value="P:negative regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000003">
        <property type="entry name" value="BTG1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF29">
        <property type="entry name" value="PROTEIN BTG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00960">
        <property type="entry name" value="BTG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGW02253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027273372.2"/>
        </source>
    </evidence>
    <sequence length="158" mass="17682" checksum="5B91563BAE4CB74C" modified="2011-11-16" version="1">MSHGKRTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSRALQDALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHRLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPVAASYGLLTCKNQMMLGRSSPSKNYVMAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3HR60</accession>
    <name>G3HR60_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein KIAA0240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">Bicral</name>
        <name evidence="3" type="ORF">I79_013323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6 7 8">17A/GY</strain>
            <tissue evidence="6 7 8">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000627">
        <property type="protein sequence ID" value="EGW06824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007644702.1">
        <property type="nucleotide sequence ID" value="XM_007646512.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244954.1">
        <property type="nucleotide sequence ID" value="XM_027389153.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244956.1">
        <property type="nucleotide sequence ID" value="XM_027389155.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306258.1">
        <property type="nucleotide sequence ID" value="XM_035450367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HR60"/>
    <dbReference type="STRING" id="10029.G3HR60"/>
    <dbReference type="PaxDb" id="10029-XP_007617789.1"/>
    <dbReference type="GeneID" id="100768726"/>
    <dbReference type="KEGG" id="cge:100768726"/>
    <dbReference type="CTD" id="23506"/>
    <dbReference type="eggNOG" id="ENOG502QPQ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HR60"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052438">
        <property type="entry name" value="Chromatin_remod/trans_coact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015671">
        <property type="entry name" value="GSCR1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15572:SF2">
        <property type="entry name" value="BRD4-INTERACTING CHROMATIN-REMODELING COMPLEX-ASSOCIATED PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15572">
        <property type="entry name" value="GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15249">
        <property type="entry name" value="GLTSCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLTSCR protein conserved" evidence="2">
        <location>
            <begin position="738"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGW06824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027244954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027244956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035306258.1"/>
        </source>
    </evidence>
    <sequence length="1104" mass="117766" checksum="08FF7DD5B2776A11" modified="2011-11-16" version="1">MDDDDDSCLLDLIGDPQALNYFLHGPSNKSVSDRQVSQTDIAFDSPHSASNHHVEFAPLQSSDDLTNAGYSAANSNSIFANSTNADPKSSLKGVSNQLGEGPSDGLPLSSSLQFLEDELESSPLPDLGEDQPFDILQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNYSGQTLQPIGVTHVPVGASFASNTVGVQHGFMQHVGISVPSQHLPNSSQISGSGQIQLIGSFGNQPSMMTINNLDGSQIILKGSGQQTPTNVSGGLLVHRQTPNGNSLFGNSTSSPVAQPVTVPFNSTNFQASLPVHNIIIQRGLAPNSNKVPINIQPKPIQMGQQSAYNVNSLGIQQHHVQQGISFASASSPQGSVVGPHMSVNIVNQQNTRKPVTSQAVSSAGGSIVIHSPMGQPHTPQSQFLIPTSLSVSSNSVHHVQTINGQLLQTQPSQLISGQVASEHVMLNRNSSNMLRTNQPYSGQMLNNQNAAVQLVSGQTFATSGSPVIVNHASPQMVGGQMPLQRASPTVLHLSPGQSSASQGRPGFTAMPSVTSMSGPARFPTVSSASTAHTSLGSTVQSGASGSNFTGDQLTQPNRTPVPVSVSHRLPVSSSKPTSTFSNTPGTQQQFFCQAQKKCLTQPSPLPTAKTTDGLRQSQIPGLLSTALPGQDSGSKVMPASLGTAQPQQENTVGSSPSQTTVQVDSHSGQKRPATKQLTKGAFILQQLQRDQAHAVTPDKSQFRSLSDTVQRLLSYHVCQGSTPTEEDLRKVDNEFEEVATQLLKRTQAMLNKYRFLLLEDAMRINPSAEMVMIDRMFNQEERASLSRDKRLALVDPEGFQADFCCSFKVDEAAPEAPLDRSDQHRSKTSSLHQAPRSQSRDRPKAGMAEATNHDQFHLVPNHIVVSGEGSVSKKSEGHGRTLKYDKGGLGQYRGAPEDKGSRRDPANASGCSPGPEGHRKTMPRPDHGPESKLPGILASAHLEMPCLDSFQDRALRNSPKNEVLHTDIMKGSGEPQPDLQLTKSLEKTFKNILELKKAGRPQSDPAASGAMDLDFPSFSPMASQENCLEKFIPDHSEGVVETDSILEAAVNSILEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G3HS21</accession>
    <name>G3HS21_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP:AMP phosphotransferase AK3, mitochondrial</fullName>
            <ecNumber evidence="8">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Adenylate kinase 3</fullName>
            <shortName evidence="8">AK 3</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Adenylate kinase 3 alpha-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">Ak3</name>
        <name evidence="8" type="synonym">AK3</name>
        <name evidence="12" type="ORF">H671_3g9368</name>
        <name evidence="11" type="ORF">I79_013646</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + AMP = GDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:29863"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="8"/>
    <dbReference type="EMBL" id="JH000649">
        <property type="protein sequence ID" value="EGW07663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE671918">
        <property type="protein sequence ID" value="ERE79743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506355.1">
        <property type="nucleotide sequence ID" value="XM_003506307.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262244.1">
        <property type="nucleotide sequence ID" value="XM_027406443.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HS21"/>
    <dbReference type="STRING" id="10029.G3HS21"/>
    <dbReference type="PaxDb" id="10029-XP_007632001.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008551.1">
        <property type="protein sequence ID" value="ENSCGRP00001005546.1"/>
        <property type="gene ID" value="ENSCGRG00001007296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760312"/>
    <dbReference type="KEGG" id="cge:100760312"/>
    <dbReference type="CTD" id="50808"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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                <person name="Wang J."/>
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        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
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                <person name="Lee K.H."/>
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        </citation>
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        <property type="entry name" value="THIOSULFATE:GLUTATHIONE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732257" evidence="2">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR642457-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGW08550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027274786.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14466" checksum="008C43E7E03659BC" modified="2011-11-16" version="1">MLRVALLRLSHTVASAGTMTGVPTVSFSELRSLLASGRARLFDVRSREEAEAGTIPGALNIPVSELEVALTMDPAAFQALYSAEKPKLEDKNLIFFCQLGKRGFQATQLAQSLGYTGARNYPGAYKEWLEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3HWR9</accession>
    <name>G3HWR9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15 19">Olfactory receptor 10G3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">LOC100773730</name>
        <name evidence="14" type="ORF">H671_1g2259</name>
        <name evidence="13" type="ORF">I79_015417</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000837">
        <property type="protein sequence ID" value="EGW08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE664682">
        <property type="protein sequence ID" value="ERE89586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003507740.1">
        <property type="nucleotide sequence ID" value="XM_003507692.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242301.1">
        <property type="nucleotide sequence ID" value="XM_027386500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HWR9"/>
    <dbReference type="STRING" id="10029.G3HWR9"/>
    <dbReference type="PaxDb" id="10029-XP_007614088.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018110.1">
        <property type="protein sequence ID" value="ENSCGRP00001013873.1"/>
        <property type="gene ID" value="ENSCGRG00001014905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773730"/>
    <dbReference type="KEGG" id="cge:100773730"/>
    <dbReference type="eggNOG" id="ENOG502SHXU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244869"/>
    <dbReference type="OMA" id="IYYVPCA"/>
    <dbReference type="OrthoDB" id="9975554at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 13 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE89586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027242301.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34900" checksum="4AD213C341423179" modified="2011-11-16" version="1">MERVNYTLLTEFILTGVPHPPRLRTFLLVFFLLIYILTQLGNLLILITVSADTQLHARPMYIFLGALSIIDMGISTIIVPRLMMNFTLGVKPIPFGGCVAQLYFYHFLGSSQCFLYTTMAYDRYLAICQPLRYPVLMSAKLSTLLVAGAWVAGSIHGAIQAILTFRLPYCGPNQVDYFFCDIPAVLKLACADTTVNELVTFVDIGVVVASCFSLILLSYIYIIRAILRIRTADGRRRAFSTCGAHVTIVTVYYVPCAFIYLRPDSHSVLDGAAALFPTAITPFLNPLIYTLRNQEVKLALRRMIGGQRAKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3HYC3</accession>
    <name>G3HYC3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-acetyltransferase 8 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative N-acetyltransferase CML1-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative N-acetyltransferase CML2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100771416</name>
        <name evidence="6" type="ORF">H671_8g19063</name>
        <name evidence="5" type="ORF">H671_8g19286</name>
        <name evidence="4" type="ORF">I79_016048</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000918">
        <property type="protein sequence ID" value="EGW02935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE682619">
        <property type="protein sequence ID" value="ERE66618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE682572">
        <property type="protein sequence ID" value="ERE66925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035304885.1">
        <property type="nucleotide sequence ID" value="XM_035448994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HYC3"/>
    <dbReference type="STRING" id="10029.G3HYC3"/>
    <dbReference type="PaxDb" id="10029-XP_007628581.1"/>
    <dbReference type="GeneID" id="100771416"/>
    <dbReference type="KEGG" id="cge:100771416"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF48">
        <property type="entry name" value="N-ACETYLTRANSFERASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGW02935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ERE66618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ERE66925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035304885.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25432" checksum="6332ABF3BA1F9AE2" modified="2011-11-16" version="1">MAPYHIRQYQERDHKQVLDLFSRGMEEHIPASFYHALTLPRTFLLLLGIPIALVLVSGSWLLGIMCAFFLLLLLWLLAGQPLKKFVATCLHTDLGDITKSYLSELGSCFLVAETEGQVVGMAAALPVKDPSLKRKQLLLFHLSVSSQHRGRGIAKALIRAVLQFARTQGYSDVVLRTSVLMRDAVALYEGMGFQKTGESFFNTIAKIMTVPSIHFRYPLPTAQEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3I3J6</accession>
    <name>G3I3J6_CRIGR</name>
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        <recommendedName>
            <fullName evidence="9">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Usb1</name>
        <name evidence="9" type="synonym">USB1</name>
        <name evidence="11" type="ORF">I79_018004</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end uridylyl-adenosine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine</text>
            <dbReference type="Rhea" id="RHEA:67896"/>
            <dbReference type="Rhea" id="RHEA-COMP:17385"/>
            <dbReference type="Rhea" id="RHEA-COMP:17386"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:85644"/>
            <dbReference type="ChEBI" id="CHEBI:176518"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine</text>
            <dbReference type="Rhea" id="RHEA:46052"/>
            <dbReference type="Rhea" id="RHEA-COMP:17384"/>
            <dbReference type="Rhea" id="RHEA-COMP:17385"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:85643"/>
            <dbReference type="ChEBI" id="CHEBI:85644"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:46053"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with PLRG1, CDC5L and PRPF19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="JH001191">
        <property type="protein sequence ID" value="EGW12718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003509842.1">
        <property type="nucleotide sequence ID" value="XM_003509794.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261502.1">
        <property type="nucleotide sequence ID" value="XM_027405701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I3J6"/>
    <dbReference type="STRING" id="10029.G3I3J6"/>
    <dbReference type="PaxDb" id="10029-XP_007637320.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013257.1">
        <property type="protein sequence ID" value="ENSCGRP00001009083.1"/>
        <property type="gene ID" value="ENSCGRG00001011243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762459"/>
    <dbReference type="KEGG" id="cge:100762459"/>
    <dbReference type="CTD" id="79650"/>
    <dbReference type="eggNOG" id="KOG3102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004596"/>
    <dbReference type="OMA" id="KTVVLQY"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1140.10:FF:000006">
        <property type="entry name" value="U6 snRNA phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW12718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027261502.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30418" checksum="20F917A19BA2DA9F" modified="2011-11-16" version="1">MSAAPLVGYSSSGSEDETEAPAAAGRSKPRSGGRRCGQNSLPTQRFPVPDSVLSMFSSTEEGPEDDSTKHGGRIRTFPHERGNWATHIYIPYEAKEEFLDLLDVLLSRAQTFVPRLVQMEEFHLSLSQSVVLRHHWILPFVQALKDHMASFQRFFFTANQVKIYTNQEKTRTFIGLEVTSGHAQFLDLVSEVDRVMEEFDLTTFYQNPSFHVSLAWCVGDACLQLEGQCLQELQEIVDEFEDSEMLLRVLAEQVRCKSGNKFFSMPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3I421</accession>
    <name>G3I421_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide-1-phosphate transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Glycolipid transfer protein domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 27 28" type="primary">Cptp</name>
        <name evidence="22" type="ORF">H671_2g6114</name>
        <name evidence="21" type="ORF">I79_018200</name>
    </gene>
    <organism evidence="21 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27 28">17A/GY</strain>
            <tissue evidence="27 28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) = N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:45688"/>
            <dbReference type="ChEBI" id="CHEBI:85378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45689"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:45680"/>
            <dbReference type="ChEBI" id="CHEBI:72963"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:45681"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GLTP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001219">
        <property type="protein sequence ID" value="EGW07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE668115">
        <property type="protein sequence ID" value="ERE84257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510016.1">
        <property type="nucleotide sequence ID" value="XM_003509968.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648822.1">
        <property type="nucleotide sequence ID" value="XM_007650632.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254396.1">
        <property type="nucleotide sequence ID" value="XM_027398595.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254397.1">
        <property type="nucleotide sequence ID" value="XM_027398596.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I421"/>
    <dbReference type="STRING" id="10029.G3I421"/>
    <dbReference type="GlyGen" id="G3I421">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007606868.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008009.1">
        <property type="protein sequence ID" value="ENSCGRP00001005234.1"/>
        <property type="gene ID" value="ENSCGRG00001006839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769709"/>
    <dbReference type="KEGG" id="cge:100769709"/>
    <dbReference type="CTD" id="80772"/>
    <dbReference type="eggNOG" id="KOG4189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161763"/>
    <dbReference type="OMA" id="ICTDSYN"/>
    <dbReference type="OrthoDB" id="116883at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900226">
        <property type="term" value="P:negative regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000002">
        <property type="entry name" value="Ceramide-1-phosphate transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF20">
        <property type="entry name" value="CERAMIDE-1-PHOSPHATE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="20">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGW07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ERE84257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027254396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027254397.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24708" checksum="C3B64A71B97B4439" modified="2011-11-16" version="1">MDGPETDFNLKVVLISFKQCLNEEEEVLLDHYINSWKGLVRFLNSLGAVFSFISKDVVSKLQIMEHLRKSPQYEHYTSLQSMVAYEVGNKLVDLDRRSRSRYPNSGCRTVLRLHRALRWLQLFLEGLRTSSEDARTSTLCSDAYNATLAAYHTWIVRQAVTVAFCALPTRKVFLEAMNVGSSEQAVEMLGEALPFIEHVYDISQKLYADHSLLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3I4H6</accession>
    <name>G3I4H6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3 7">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">Aldoa</name>
        <name evidence="9" type="ORF">I79_018355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13 14">17A/GY</strain>
            <tissue evidence="12 13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3 7"/>
    <dbReference type="EMBL" id="JH001251">
        <property type="protein sequence ID" value="EGW09867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510151.1">
        <property type="nucleotide sequence ID" value="XM_003510103.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510153.1">
        <property type="nucleotide sequence ID" value="XM_003510105.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648928.1">
        <property type="nucleotide sequence ID" value="XM_007650738.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260428.1">
        <property type="nucleotide sequence ID" value="XM_027404627.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260429.1">
        <property type="nucleotide sequence ID" value="XM_027404628.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260430.1">
        <property type="nucleotide sequence ID" value="XM_027404629.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I4H6"/>
    <dbReference type="STRING" id="10029.G3I4H6"/>
    <dbReference type="GlyGen" id="G3I4H6">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007612443.1"/>
    <dbReference type="GeneID" id="100771717"/>
    <dbReference type="CTD" id="226"/>
    <dbReference type="eggNOG" id="KOG1557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I4H6"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000021">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW09867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027260428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027260429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027260430.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="39382" checksum="AD0428E9D21F54C1" modified="2011-11-16" version="1">MPYPYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACTQKFSNEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYIKRALANSLACQGKYTPSGQSGAAASESLFISNHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3I6A5</accession>
    <name>G3I6A5_CRIGR</name>
    <protein>
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        <name evidence="15" type="ORF">I79_019017</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19 20 21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19 20 21">17A/GY</strain>
            <tissue evidence="19 20 21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGW10732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649459.1">
        <property type="nucleotide sequence ID" value="XM_007651269.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649460.1">
        <property type="nucleotide sequence ID" value="XM_007651270.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649461.1">
        <property type="nucleotide sequence ID" value="XM_007651271.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016835275.1">
        <property type="nucleotide sequence ID" value="XM_016979786.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255444.1">
        <property type="nucleotide sequence ID" value="XM_027399643.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255445.1">
        <property type="nucleotide sequence ID" value="XM_027399644.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255446.1">
        <property type="nucleotide sequence ID" value="XM_027399645.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255447.1">
        <property type="nucleotide sequence ID" value="XM_027399646.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295420.1">
        <property type="nucleotide sequence ID" value="XM_035439529.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317224.1">
        <property type="nucleotide sequence ID" value="XM_035461333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I6A5"/>
    <dbReference type="STRING" id="10029.G3I6A5"/>
    <dbReference type="PaxDb" id="10029-XP_007621895.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003487.1">
        <property type="protein sequence ID" value="ENSCGRP00001002583.1"/>
        <property type="gene ID" value="ENSCGRG00001002911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762071"/>
    <dbReference type="KEGG" id="cge:100762071"/>
    <dbReference type="CTD" id="164091"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161438"/>
    <dbReference type="OMA" id="FIFTTCC"/>
    <dbReference type="OrthoDB" id="535992at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF41">
        <property type="entry name" value="MEMBRANE PROGESTIN RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="12 15 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027255444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027255447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035295420.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39259" checksum="B4E3603868CBF412" modified="2011-11-16" version="1">MAMAVAQKFSHLLSSLWHVGQKPLQPEPVFTVDRAEVPPLFWKPYIYAGYRPLHQTWCFYFRTLFQQHNEAVNVWTHLLAALALLLRLVILVGSVDFWEDPHALPLFIIVLASFTYLSFSALAHLLQAKSEFWHYSFFFLDYVGVAVYQFGSALAHFYYAIEPTWHAQVQAIFLPTAAFLAWLSCAGSCYNKYSQKPGLLGRTCQEVPSALAYALDISPVVHRIIVSPLPAEDDPALLYHKCQVVFFLLAAAFFSTVMPESWFPGSCHIFGQGHQVFHVFLVLCTLAQLEAVTLDYQARRPIYEPLHARWPHNFSGLFLLTVGSSILTALLLSQLVRRKLHQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3I8F5</accession>
    <name>G3I8F5_CRIGR</name>
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        <submittedName>
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    <gene>
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    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001501">
        <property type="protein sequence ID" value="EGW11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511376.1">
        <property type="nucleotide sequence ID" value="XM_003511328.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283977.1">
        <property type="nucleotide sequence ID" value="XM_027428176.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I8F5"/>
    <dbReference type="STRING" id="10029.G3I8F5"/>
    <dbReference type="PaxDb" id="10029-XP_007631939.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007722.1">
        <property type="protein sequence ID" value="ENSCGRP00001005059.1"/>
        <property type="gene ID" value="ENSCGRG00001006585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758976"/>
    <dbReference type="KEGG" id="cge:100758976"/>
    <dbReference type="CTD" id="3860"/>
    <dbReference type="eggNOG" id="ENOG502QTM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154403"/>
    <dbReference type="OMA" id="DAKMTGF"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043555">
        <property type="term" value="P:regulation of translation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF121">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="100"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="204"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027283977.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="48104" checksum="AB15498B9C547E12" modified="2011-11-16" version="1">MSCRFQSSSTSYGGGFGAGSCQLGGGRKISTCSSRFASGGSAGGYGGGMSCGFGGGAGSGFGGGFGGSYGGGFGGGFGGGFGGGFGDFGGGDGGLLSGNEKITMQNLNDRLANYLEKVRALEAANADLEVKIRDWHLRQSPTSPERDYSAYYKTIEELRVKILEATTDNNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYLKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEALAEKNRRDAEQWFQNKSAELNKEVSSNAAMIQTSKTEITELRRTLQSLEIELQSQLSMKAGLESTLAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMTGFNNSGGTSTASNASSSPSTSGRLDFRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3IGY6</accession>
    <name>G3IGY6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribose pyrophosphatase, mitochondrial</fullName>
            <ecNumber evidence="2">3.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ADP-ribose diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Adenosine diphosphoribose pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside diphosphate-linked moiety X motif 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Nudt9</name>
        <name evidence="14" type="ORF">I79_023063</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:10412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Interacts with GLOD4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. NudF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="JH002668">
        <property type="protein sequence ID" value="EGW14483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514012.1">
        <property type="nucleotide sequence ID" value="XM_003513964.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244290.1">
        <property type="nucleotide sequence ID" value="XM_027388489.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IGY6"/>
    <dbReference type="SMR" id="G3IGY6"/>
    <dbReference type="STRING" id="10029.G3IGY6"/>
    <dbReference type="PaxDb" id="10029-XP_007636272.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014035.1">
        <property type="protein sequence ID" value="ENSCGRP00001009816.1"/>
        <property type="gene ID" value="ENSCGRG00001011849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766764"/>
    <dbReference type="KEGG" id="cge:100766764"/>
    <dbReference type="CTD" id="53343"/>
    <dbReference type="eggNOG" id="KOG4195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017405"/>
    <dbReference type="OMA" id="VQVYQGY"/>
    <dbReference type="OrthoDB" id="9972248at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046032">
        <property type="term" value="P:ADP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03670">
        <property type="entry name" value="NUDIX_ADPRase_Nudt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000021">
        <property type="entry name" value="ADP-ribose pyrophosphatase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039989">
        <property type="entry name" value="NUDT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030:SF8">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25969">
        <property type="entry name" value="NUDT9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732389" description="ADP-ribose pyrophosphatase, mitochondrial" evidence="12">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="178"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW14483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027244290.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38575" checksum="CC29427D37D2CBFA" modified="2011-11-16" version="1">MACRSLGQAVATVSLSVALASVTVRSSGCRSIPASRNSFPSCGFHLNSNIMSGSNGAKENSHNKARTSPYPGSKVERSEVPNEKVGWLVEWQDYNPVEYTAVSVLAGPQWADPQISESNFSPKFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKRDDSGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQKSSAEKREIEKKLHALFSQEHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGETMDSLTLEAGDDAGKVKWVDISDQLKLYASHSQFIRLVAEKRDAHWSEDPAADSRGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q9JI55</accession>
    <name>PLEC_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Plectin</fullName>
            <shortName>PCN</shortName>
            <shortName>PLTN</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>300 kDa intermediate filament-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>IFAP300</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Plectin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PLEC</name>
        <name type="synonym">PLEC1</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Biochem. Biophys. Res. Commun." volume="273" first="183" last="187">
            <title>The 300-kDa intermediate filament-associated protein (IFAP300) is a hamster plectin ortholog.</title>
            <authorList>
                <person name="Clubb B.H."/>
                <person name="Chou Y.-H."/>
                <person name="Herrmann H."/>
                <person name="Svitkina T.M."/>
                <person name="Borisy G.G."/>
                <person name="Goldman R.D."/>
            </authorList>
            <dbReference type="PubMed" id="10873583"/>
            <dbReference type="DOI" id="10.1006/bbrc.2000.2916"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="J. Biol. Chem." volume="271" first="8203" last="8208">
            <title>Identification of plectin as a substrate of p34cdc2 kinase and mapping of a single phosphorylation site.</title>
            <authorList>
                <person name="Malecz N."/>
                <person name="Foisner R."/>
                <person name="Stadler C."/>
                <person name="Wiche G."/>
            </authorList>
            <dbReference type="PubMed" id="8626512"/>
            <dbReference type="DOI" id="10.1074/jbc.271.14.8203"/>
        </citation>
        <scope>PHOSPHORYLATION AT THR-4328</scope>
    </reference>
    <comment type="function">
        <text>Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2 4">Homodimer or homotetramer (By similarity). Interacts (via actin-binding domain) with SYNE3. Interacts (via calponin-homology (CH) 1 domain) with VIM (via rod region). Interacts (via N-terminus) with DST isoform 2 (via N-terminus). Interacts with FER. Interacts with TOR1A (By similarity). Interacts with ANK3 (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Hemidesmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Podosome</location>
        </subcellularLocation>
        <text evidence="4">Localized to the cortex of myotube podosomes.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminus interacts with actin, the C-terminus with vimentin, desmin, GFAP, cytokeratins, lamin B; whereas both the N- and the C-terminus can bind integrin beta-4.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the plakin or cytolinker family.</text>
    </comment>
    <dbReference type="EMBL" id="AF260753">
        <property type="protein sequence ID" value="AAF70372.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q9JI55"/>
    <dbReference type="iPTMnet" id="Q9JI55"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990254">
        <property type="term" value="F:keratin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045110">
        <property type="term" value="P:intermediate filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21188">
        <property type="entry name" value="CH_PLEC-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21238">
        <property type="entry name" value="CH_PLEC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000009">
        <property type="entry name" value="dystonin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000002">
        <property type="entry name" value="Microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000036">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000076">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000064">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.780:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000002">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000065">
        <property type="entry name" value="plectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000010">
        <property type="entry name" value="plectin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000089">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041573">
        <property type="entry name" value="Desmoplakin_Spectrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049538">
        <property type="entry name" value="PCN-like_spectrin-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF20">
        <property type="entry name" value="PLECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00681">
        <property type="entry name" value="Plectin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18373">
        <property type="entry name" value="Spectrin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21019">
        <property type="entry name" value="Spectrin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21020">
        <property type="entry name" value="Spectrin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21097">
        <property type="entry name" value="SR_plectin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0965">Cell junction</keyword>
    <keyword id="KW-0966">Cell projection</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <feature type="chain" id="PRO_0000078134" description="Plectin">
        <location>
            <begin position="1" status="less than"/>
            <end position="4473"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH) 1" evidence="6">
        <location>
            <begin position="1" status="less than"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH) 2" evidence="6">
        <location>
            <begin position="87"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Spectrin 1">
        <location>
            <begin position="449"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="Spectrin 2">
        <location>
            <begin position="529"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="Spectrin 3">
        <location>
            <begin position="626"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="730"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="repeat" description="Spectrin 4">
        <location>
            <begin position="1104"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="repeat" description="Plectin 1">
        <location>
            <begin position="2615"/>
            <end position="2652"/>
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    <feature type="repeat" description="Plectin 24">
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    <feature type="repeat" description="Plectin 26">
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    <feature type="repeat" description="Plectin 28">
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    <feature type="repeat" description="Plectin 29">
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    <feature type="repeat" description="Plectin 30">
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
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                <person name="Budach W.E."/>
                <person name="Galosy S."/>
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                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
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                <person name="Wienberg J."/>
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                <person name="Leonard M."/>
                <person name="Grillari J."/>
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                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="4">
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            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">17A/GY</strain>
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            <strain evidence="5">17A/GY</strain>
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        <property type="protein sequence ID" value="ERE63545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305826.1">
        <property type="nucleotide sequence ID" value="XM_035449935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HZA2"/>
    <dbReference type="GeneID" id="100771506"/>
    <dbReference type="KEGG" id="cge:100771506"/>
    <dbReference type="CTD" id="56849"/>
    <dbReference type="OrthoDB" id="9510281at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021156">
        <property type="entry name" value="TF_A-like/BEX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04538">
        <property type="entry name" value="BEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ERE63545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035305826.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11875" checksum="F455BC4BD9CC57B8" modified="2014-09-03" version="1">MQKSSSEKEGKAQCSEPKTEDEHPYRALEGQRMEGNFRQRLLESLEEFKDDLDYRHFKGEEMTGEEEEMERCLEEIRSLRKKFRALHYNHTHSRDHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IEJ2</accession>
    <name>A0A061IEJ2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100765571</name>
        <name evidence="7" type="ORF">H671_3g9072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KE671523">
        <property type="protein sequence ID" value="ERE80137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261560.1">
        <property type="nucleotide sequence ID" value="XM_027405759.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IEJ2"/>
    <dbReference type="ESTHER" id="crigr-g3i769">
        <property type="family name" value="Carb_B_Chordata"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.956"/>
    <dbReference type="GeneID" id="100765571"/>
    <dbReference type="KEGG" id="cge:100765571"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000011">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044513395" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="31"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ERE80137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027261560.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61849" checksum="B6432C2A9918F3B7" modified="2014-09-03" version="1">MPLDRFPSWLYAVSCGLLLLFLHVHGQEAVSPIRSTHTGQVRGSLLHVKDGDIGVHTFLGIPFAKPPVGSLRFAPPEPPEPWSGVRDGTSHPAMCLQTDIMNSEFAKKMNLIMPPTSMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGGLAIGMASMNDGSILAATEDIVMVSIQYHLGILGYFSTGDEHARGNWGYLDQVAALHWVQQNIAFFGGNPGRVTIFGASAGGTSVSSLVVSPMSKGLFHGAIMQSGVALLPDLISEKSEVVYTTVANLSGCEAKDSEALVHCLRDKTEAEILAINQVFLMIPATVDGTFLTKHPRELLDSVDFHPVPSIIGIDSDECGWGIPLMKGLDHVIKNITRETLSALLKSTAAQMMLPPECGDLLMEEYMGGVKDPQTLQAQFRELLEDFMFVIPALQVAYFQRSHAPVYFYEFQHQPSYIKHVRPSHVRADHGDHLPFVFGSHLWGMKVDFTEEEKLLNRRMMKYWANFARHGNPNSEGLPYWPELVHNEQYLKLDIQPAVGRALKAEKLRFWTITLPQKIQDIKGTQVKHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IJH3</accession>
    <name>A0A061IJH3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Activating transcription factor 6 beta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16 20">Cyclic AMP-dependent transcription factor ATF-6 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Atf6b</name>
        <name evidence="16" type="ORF">H671_1g2765</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
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                <person name="Puehler A."/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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        <source>
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    <sequence length="452" mass="50990" checksum="979275EC4EB2F029" modified="2014-09-03" version="1">MASVPTAESWTDGTAGVGTQAENLSAALGVTEWLALQAGNFSSALGLPLASQAPSQARANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQIYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVVFDPNDGDPAKSSRKKRAVPRDPSANGCSRKDSKSASTTSSFISSPYTSVDEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IN96</accession>
    <name>A0A061IN96_CRIGR</name>
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        <name type="scientific">Cricetulus griseus</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KE665331">
        <property type="protein sequence ID" value="ERE88911.1"/>
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        <location>
            <begin position="41"/>
            <end position="63"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ERE88911.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035306683.1"/>
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    <sequence length="107" mass="11340" checksum="4E38C6A89558A496" modified="2014-09-03" version="1">MSGADPSSGFAGSVENGTFLELFPTSLSTSVDPSSGHLSNVYIYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS</sequence>
</entry>
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    <accession>A0A3L7GNE5</accession>
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        <recommendedName>
            <fullName evidence="4">F-box only protein 39</fullName>
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    <gene>
        <name evidence="6 9" type="primary">Fbxo39</name>
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    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Euarchontoglires</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with SKP1 and CUL1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027281976.1">
        <property type="nucleotide sequence ID" value="XM_027426175.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7GNE5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026169.1">
        <property type="protein sequence ID" value="ENSCGRP00001021925.1"/>
        <property type="gene ID" value="ENSCGRG00001020628.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754321"/>
    <dbReference type="KEGG" id="cge:100754321"/>
    <dbReference type="CTD" id="162517"/>
    <dbReference type="GeneTree" id="ENSGT00510000048837"/>
    <dbReference type="OrthoDB" id="61560at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22108">
        <property type="entry name" value="F-box_FBXO39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000027">
        <property type="entry name" value="F-box only protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000237">
        <property type="entry name" value="F-box only protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF160">
        <property type="entry name" value="F-BOX ONLY PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027281976.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="52473" checksum="63EAE532CCFCEF7B" modified="2019-02-13" version="1">MDEEGEVIQPQEQSCWASLPDVCLRRIFWWLGDRDRSRAALVCRKWNQMMYSADLWRYRTITFSGRPSRVHASEFESALWYVKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLKSLSIQHLELDRLVWRNSIRGSLIKSLSFFLKKMGKHLDHLSLKGARLTVEQGCHILNSLSYLRNENLASELNIEDFFSHHLAVYGSSQFNKAMATFHNLTFLTLNYNCISDELLETLSENNAGTLRTMNIKCHVHDPHGQVVWGMSWAKLARQAGSLKVNFFFERVMKYERLARILLQEIPVRSISLRSCYFSDPDWSMRPTLMDLLPTFRNTLQKLTFEFNNNHESLDEQLHLLILACRKLFYFKIWAFLDVKFVERILKSQEEGQCSLRTLKVRIYTNRYETNEEDRTLREIYRKYRKLIDSELNYFVIAYPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H5C5</accession>
    <name>A0A3L7H5C5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="20">ATP-binding cassette sub-family D member 1 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">ATP-binding cassette, sub-family D member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Abcd1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:67073"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027288180.1">
        <property type="nucleotide sequence ID" value="XM_027432379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H5C5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022081.1">
        <property type="protein sequence ID" value="ENSCGRP00001017837.1"/>
        <property type="gene ID" value="ENSCGRG00001017773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769988"/>
    <dbReference type="KEGG" id="cge:100769988"/>
    <dbReference type="CTD" id="215"/>
    <dbReference type="GeneTree" id="ENSGT00950000182955"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015607">
        <property type="term" value="F:ABC-type fatty-acyl-CoA transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036109">
        <property type="term" value="P:alpha-linolenic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901570">
        <property type="term" value="P:fatty acid derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055089">
        <property type="term" value="P:fatty acid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043217">
        <property type="term" value="P:myelin maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900016">
        <property type="term" value="P:negative regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903427">
        <property type="term" value="P:negative regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990535">
        <property type="term" value="P:neuron projection maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032000">
        <property type="term" value="P:positive regulation of fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001280">
        <property type="term" value="P:positive regulation of unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051900">
        <property type="term" value="P:regulation of mitochondrial depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055092">
        <property type="term" value="P:sterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036113">
        <property type="term" value="P:very long-chain fatty-acyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005283">
        <property type="entry name" value="FA_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00954">
        <property type="entry name" value="3a01203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF21">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="99"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="474"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027288180.1"/>
        </source>
    </evidence>
    <sequence length="736" mass="82041" checksum="659C64C3F0B39766" modified="2019-02-13" version="1">MPVLSTPRSSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGEPTQETSGVTAAKAGMNRVFLQRLLVLLRLLFPRILCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYSLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLRQSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSETMKKAALEMKEEELVSERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVQHCHFKRTGDLEEAQAKPGAMVQSGIHVEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAVRLSLTEEKQRLEQQLAGIPKMQGRLQELCQILGETAAPVQPLVPGVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HAB4</accession>
    <name>A0A3L7HAB4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kremen protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Kringle-containing protein marking the eye and the nose</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Kremen2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with ERLEC1. Forms a ternary complex with DKK1 and LRP6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303917.1">
        <property type="nucleotide sequence ID" value="XM_035448026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HAB4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016550.1">
        <property type="protein sequence ID" value="ENSCGRP00001012317.1"/>
        <property type="gene ID" value="ENSCGRG00001013757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771248"/>
    <dbReference type="KEGG" id="cge:100771248"/>
    <dbReference type="CTD" id="79412"/>
    <dbReference type="GeneTree" id="ENSGT00940000162126"/>
    <dbReference type="OrthoDB" id="431034at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030279">
        <property type="term" value="P:negative regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.20.10:FF:000006">
        <property type="entry name" value="Kremen protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000037">
        <property type="entry name" value="Kremen protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017076">
        <property type="entry name" value="Kremen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF15">
        <property type="entry name" value="KREMEN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036961">
        <property type="entry name" value="Kremen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 14" id="KW-0420">Kringle</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594365" description="Kremen protein" evidence="16">
        <location>
            <begin position="25"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="18">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="19">
        <location>
            <begin position="120"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="218"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="194"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036961-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035303917.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="49335" checksum="B4591729CA190D3C" modified="2019-02-13" version="1">MGTWALQCLLFLFPMLLPPHGASAGSLHNPGLSECFQVNGADYRGHQNYTGPRGAGRPCLFWDQTQQHSYSSASDPQGRWGLGAHNFCRNPDGDVQPWCYVPETEEGIYWRYCDIPTCHMPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRPAPATDCDQICFGHPGQLCGGDGRLGIYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWVLGQMGAVLELTFRLFELADSRDRLELRDASSGNLLRAFDGAHPPPPGPLRLRTAALLLTFRSDARGHAQGFALTYRGLQDTVEDSASAKDSAETTAGDPDGANVSCSPKPGAAQASIGARVFSTVMAISVLLLLILSLLRLLRRRSCLLAPGKGSLALGPSRGPRRSWAVWYRRPRVVALPCPPGDSQAEGPAAGYRPLSASSQSSLRSLISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HHE7</accession>
    <name>A0A3L7HHE7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="21 24">Chromosome-associated kinesin KIF4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">LOC100754439</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027275349.1">
        <property type="nucleotide sequence ID" value="XM_027419548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HHE7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013626.1">
        <property type="protein sequence ID" value="ENSCGRP00001009416.1"/>
        <property type="gene ID" value="ENSCGRG00001011542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754439"/>
    <dbReference type="KEGG" id="cge:100754439"/>
    <dbReference type="GeneTree" id="ENSGT00940000164190"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000038">
        <property type="entry name" value="chromosome-associated kinesin KIF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13 17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="20">
        <location>
            <begin position="9"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1039"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1183"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="554"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="820"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1205"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027275349.1"/>
        </source>
    </evidence>
    <sequence length="1220" mass="137560" checksum="B4297DE27441869D" modified="2019-02-13" version="1">MKEEVKGIPVRVALRCRPLVPKEIGEGCQMCLSFVPGKPQVVIGTDKSFTYDYVFDPSTEQEEVFNTAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYSADQGSEQTVGVIPRVIQLLFKEMDEERDSEFTLSVSYLEIYNEEILDLLCSPCEKASQIHIREDPKAGIKIVGLTERTVSDASDMVSCLEQGNNSRTVAATAMNSQSSRSHAIFTISVRQRKKTDTNSSFHSKLCLVDLAGSERQKKTKAEGDRLKEGIHINQGLLCLGNVISALGDGKKGGFVPYRDSRLTRLLQDSLGGNSHTLMIACVSPADSSLEETLNTLRYADRARKIKNKPVVNTDPQTAELNHLKRQVKQLQVLLLQTRGGSLPGSINLEPSETLRSLMEKNQSLVEENEKLSHALSEAAGQTAQMLERILTTEQANEKINTKLQELRHHAACKLDLQKLMETLEDQELIENVETIHSLQQVIIHLSDETVAFLAAATESAMELDAQVVDRPETSRSCDSFTTQYALRQAQMAKELTELNKALTLKEALARKITFSGQLQPIQGQYEANIKSLESEVSILQKEKEQLLLELQTAKKDVNQTKLSEHRRRCLQDLEAQIAGLKKKLNEQSKLLKLKESTENTVSKLTLEIQMMKTQRVQLMRQMKEDAEKSRQWKQQKNKEVIQLKEQDRKRRYELLKLERDFQKQSNVLRRKTEEAAAANKRLKDALQKQQEATDKRKETQSRGIESTEARVKNWLRNEIEVRISTEEVKLHLNDLLEERKILAMNVAQLRENKEPGENPPPKLQRSASNSDEVCGHVSELENSITKQIRSLESEMELRSAQIADLQQKLLDAESEDRSKRHWENITTILEAKCALKYLVGELVSSKLCVSELESNLKQTQASCSKMQMMLFEEQSHLVVVETELKAELLKVEQKHQETVLALLSQLQQRPTAEKPPEVWVSGKEQQLLDTLQCQDEQVRKMQELCEQNQQLLQENEIITQKLTLLQGAKGQKLHLGKDGLQSPDSSFDYIPTLPKPSRVRDKFLEQSMDTENSANESEDGDADDEEWKPRKLAKVPRKTMQGCSCRGWCKNRHCGCRKQGVDCTVACGCDPTKCRNLQKEQDSLGTIEWNQDSEGSFKLEDPTEVTPGLSFFNPVCATPNTKTLKETCDMGQVLLRKTALAVSLDPPDIKYRATESQENKATRKKKKRALTNNSSFFSGCSPTTEENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HYR2</accession>
    <name>A0A3L7HYR2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Lipn</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035298977.1">
        <property type="nucleotide sequence ID" value="XM_035443086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313958.1">
        <property type="nucleotide sequence ID" value="XM_035458067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HYR2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024173.1">
        <property type="protein sequence ID" value="ENSCGRP00001019929.1"/>
        <property type="gene ID" value="ENSCGRG00001019228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761667"/>
    <dbReference type="KEGG" id="cge:100761667"/>
    <dbReference type="CTD" id="643418"/>
    <dbReference type="GeneTree" id="ENSGT00940000161695"/>
    <dbReference type="OMA" id="YACEEHT"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000012">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594437" description="Lipase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="81"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035298977.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="46079" checksum="1B7BD521D1B19816" modified="2019-02-13" version="1">MPMMWLFLTTTCLIHETLSVSELFDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTADGYILTLNRIPHGRAQAGLTGTRPVVYMQHALFADNAYWLENFANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSANEEKFWAFSFDEMAKYDLPGIIDFIVNKTGQEKLYFIGHSLGTTIGFIAFSTMPELAQRIKMNFAMGPVISFKYPTSIFTSFFLLPNSIIKHIFGTKGFFLEDKKAKATYIKVCNRKILRPMCSEFMSLWAGFNKKNMNMSRLDVYMSHAPTGSSIQNILHIKQLYRSDEFRAYDWGSEAENMNHYNQSRPPIYDLTAMKVPTAIWAGGHDALITPQDVARILPQVTNLRYFKLFPDWNHFDFVWGLDAPQRLYSKIIGLMREYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I299</accession>
    <name>A0A3L7I299_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional repressor scratch 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Scratch homolog 1 zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Scrt1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027260080.1">
        <property type="nucleotide sequence ID" value="XM_027404279.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I299"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028821.1">
        <property type="protein sequence ID" value="ENSCGRP00001024575.1"/>
        <property type="gene ID" value="ENSCGRG00001022448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103159753"/>
    <dbReference type="KEGG" id="cge:103159753"/>
    <dbReference type="CTD" id="83482"/>
    <dbReference type="GeneTree" id="ENSGT00940000154491"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001222">
        <property type="term" value="P:regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000560">
        <property type="entry name" value="Scratch family transcriptional repressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000169">
        <property type="entry name" value="transcriptional repressor scratch 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF60">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR SCRATCH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027260080.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="35975" checksum="398D5A4195713EA2" modified="2019-02-13" version="1">MPRSFLVKKVKLDTFSSADLDSSYGRARSDLGVRLQDKGYLSDYVGPASVYDGDTEAALLKGPSPEPMYAAAVRGELGPAASGSAPPPTPRPELATAAGGYINGDAAVSEGYAADAFFITDGRSRRKAANANAAAATSTASVAAPDSDTGGGGGPGTRGSGSGSASRGGTRVGAGTEARSGPGAPGAGGRHACGECGKTYATSSNLSRHKQTHRSLDSQLARRCPTCGKVYVSMPAMAMHLLTHDLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHFQCKRCKKSFALKSYLNKHYESACFKGGAGGPATPAPPQLSPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I8F5</accession>
    <name>A0A3L7I8F5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family with sequence similarity 110, member D</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8 9">Protein FAM110D isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 8 9" type="primary">Fam110d</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8 9">17A/GY</strain>
            <tissue evidence="8 9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM110 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255430.1">
        <property type="nucleotide sequence ID" value="XM_027399629.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255431.1">
        <property type="nucleotide sequence ID" value="XM_027399630.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I8F5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003155.1">
        <property type="protein sequence ID" value="ENSCGRP00001002404.1"/>
        <property type="gene ID" value="ENSCGRG00001002609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771715"/>
    <dbReference type="KEGG" id="cge:100771715"/>
    <dbReference type="CTD" id="79927"/>
    <dbReference type="GeneTree" id="ENSGT00950000183056"/>
    <dbReference type="OrthoDB" id="10028183at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025740">
        <property type="entry name" value="FAM110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025741">
        <property type="entry name" value="FAM110_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025739">
        <property type="entry name" value="FAM110_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14758">
        <property type="entry name" value="AGAP005440-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14758:SF3">
        <property type="entry name" value="PROTEIN FAM110D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14160">
        <property type="entry name" value="FAM110_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14161">
        <property type="entry name" value="FAM110_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosome-associated FAM110 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosome-associated FAM110 C-terminal" evidence="3">
        <location>
            <begin position="145"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027255430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027255431.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="28700" checksum="ACB874D15AE25995" modified="2019-02-13" version="1">MLLSSPSTPSRGRTPSAVERLEADKAKYVKTQQVIVRRQEPALRGGPGPLTPHPCNELGASASPRTPGPARRGSGRRQPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGGPRDAAPSSPGPTERPAAPAGWAGSPDAPEASGKRALCPTCSLPLSEKERFFNYCGLERALVEVLGAERFSPQSWGAEHSPQVATPPLPGSGDTSDWTSSDGDAGTPDCAGGCGGGSQAAGSARDGRPSVSVVERNARVIQWLYGCQRARAPPRESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I9L2</accession>
    <name>A0A3L7I9L2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbonic anhydrase</fullName>
            <ecNumber evidence="11">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Ca1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>urea = cyanamide + H2O</text>
            <dbReference type="Rhea" id="RHEA:23056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16698"/>
            <dbReference type="EC" id="4.2.1.69"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="11"/>
    <dbReference type="RefSeq" id="XP_035294887.1">
        <property type="nucleotide sequence ID" value="XM_035438996.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303868.1">
        <property type="nucleotide sequence ID" value="XM_035447977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I9L2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012053.1">
        <property type="protein sequence ID" value="ENSCGRP00001007961.1"/>
        <property type="gene ID" value="ENSCGRG00001010317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772227"/>
    <dbReference type="KEGG" id="cge:100772227"/>
    <dbReference type="CTD" id="759"/>
    <dbReference type="GeneTree" id="ENSGT00940000161270"/>
    <dbReference type="OMA" id="FHVNYED"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018820">
        <property type="term" value="F:cyanamide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF282">
        <property type="entry name" value="CARBONIC ANHYDRASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035294887.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28387" checksum="A38FDF7F241BF674" modified="2019-02-13" version="1">MASANWGYDGKNGPDQWSKLYPIANGNNQSPIDIKTSEAKHDSSLKPIGVSYNPATAKEIVNVGHSFQVLFDDSGNQSVLKGGPLSESYRLTQFHFHWGNSNDHGSEHTLDGVKFSGELHLVHWNSAKYSSAAEAVSKPDGMAILGVFLKVGPANPNVQKVLDALNSVKTKGKRAPFTNFDPSCLLPSSLDYWTYFGSLTHPPLHESVTWFICKESISVSPEQLAQLRSVLSNAEGEAAVPILTNHRPTQPLKGRTVTASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LCE4</accession>
    <name>A0A8C2LCE4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Protein SYS1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">LOC100764663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein trafficking. May serve as a receptor for ARFRP1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ARFRP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279263.1">
        <property type="nucleotide sequence ID" value="XM_027423462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LCE4"/>
    <dbReference type="SMR" id="A0A8C2LCE4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002761.1">
        <property type="protein sequence ID" value="ENSCGRP00001002163.1"/>
        <property type="gene ID" value="ENSCGRG00001002260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764663"/>
    <dbReference type="KEGG" id="cge:100764663"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016973">
        <property type="entry name" value="Integral_membrane_SYS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031402">
        <property type="entry name" value="SYS1_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR031402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027279263.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17554" checksum="814BC83146DD285B" modified="2022-01-19" version="1">MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDALVRSSPSLDQMFDAEILGFSTPPGRLSMMSFVLNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWLYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLSSAPKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LGM7</accession>
    <name>A0A8C2LGM7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane 239</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Transmembrane protein 239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Tmem239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035302805.1">
        <property type="nucleotide sequence ID" value="XM_035446914.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306553.1">
        <property type="nucleotide sequence ID" value="XM_035450662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LGM7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001787.1">
        <property type="protein sequence ID" value="ENSCGRP00001001597.1"/>
        <property type="gene ID" value="ENSCGRG00001001392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771084"/>
    <dbReference type="KEGG" id="cge:100771084"/>
    <dbReference type="CTD" id="100288797"/>
    <dbReference type="GeneTree" id="ENSGT00390000005090"/>
    <dbReference type="OMA" id="RWCMCHV"/>
    <dbReference type="OrthoDB" id="9451631at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031694">
        <property type="entry name" value="TMEM239"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37356">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37356:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15841">
        <property type="entry name" value="TMEM239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035302805.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17006" checksum="68AE58D56256C7D3" modified="2022-01-19" version="1">MQQPRVETDIIGAGEGPQRAVPWSAWVTRQDWVRWWACHMPRSWSQWWNTSGWRQPLQRMLWGLEGTLYLLLALMLCHALFTTGSHLLSSLWPVVAVVWSHLLPAILLLVLSAMPALLFAASFLLLFSTLLSLVGLLTSMTHPGYAQDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LMJ7</accession>
    <name>A0A8C2LMJ7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Single-stranded DNA binding protein 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Single-stranded DNA-binding protein 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Ssbp3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003515074.1">
        <property type="nucleotide sequence ID" value="XM_003515026.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252464.1">
        <property type="nucleotide sequence ID" value="XM_027396663.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LVA2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013368.1">
        <property type="protein sequence ID" value="ENSCGRP00001009185.1"/>
        <property type="gene ID" value="ENSCGRG00001011326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752094"/>
    <dbReference type="KEGG" id="cge:100752094"/>
    <dbReference type="CTD" id="84926"/>
    <dbReference type="GeneTree" id="ENSGT00940000158675"/>
    <dbReference type="OMA" id="EEDDTMM"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12908">
        <property type="entry name" value="SPRYD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035783">
        <property type="entry name" value="SPRYD3_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027252464.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49654" checksum="DA1A92651E85D85B" modified="2022-01-19" version="1">MRRTRRPRFVLMNKMDDLNLHYRFLNWRRRIREIREVRAFRYQERFKHILVDGDTLSYHGNSGEVGCYVASRPLTKDSNYFEVSIVDSGVRGTIAVGLVPQYYSLDHQPGWLPDSVAYHADDGKLYNGRAKGRQFGSKCNSGDRIGCGIEPVSFDVQTAQIFFTKNGKRVGSTIMPMSPDGLFPAVGMHSLGEEVRLHLNAELGREDDSVMMVDSYEDEWGRLHDVRVCGTLLEYLGKGKSIVDVGLAQARHPLSTRSHYFEVEIVDPGEKCYIALGLARKDYPKNRHPGWSRGSVAYHADDGKIFHGSGVGDPFGPRCYKGDIMGCGIMFPRDYILDSEGDSDDSCDTVILSPTARAVRNVRNVMYLHQEGEEEEEEEEEEEEEEIEQEHEGKKVVVFFTRNGKIIGKKDAVVPSGGFFPTIGMLSCGEKVKVDLHPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LWH4</accession>
    <name>A0A8C2LWH4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ALX homeobox protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cartilage homeoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Alx1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027249954.1">
        <property type="nucleotide sequence ID" value="XM_027394153.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LWH4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013576.1">
        <property type="protein sequence ID" value="ENSCGRP00001009370.1"/>
        <property type="gene ID" value="ENSCGRG00001011492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759154"/>
    <dbReference type="KEGG" id="cge:100759154"/>
    <dbReference type="CTD" id="8092"/>
    <dbReference type="GeneTree" id="ENSGT00940000158251"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014031">
        <property type="term" value="P:mesenchymal cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010718">
        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048864">
        <property type="term" value="P:stem cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000093">
        <property type="entry name" value="ALX homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF359">
        <property type="entry name" value="ALX HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 13 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="11 13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="16">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="13">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027249954.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36900" checksum="42EA4427545CD578" modified="2022-01-19" version="1">MEFLSEKFALKSPPSKNSDFYMGTGGALEHVMETLDNESFYGKATAGKCVQAFGPLPRAEHHVRLDRTSPCQDSSVNYGITKVEGQPLHTELNRAMDSCNNLRMSPVKGMPEKGELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWPGNASGGSVVTSCMLPRDASSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFETKPEFERRSSSIAVLRMKAKEHTANISWAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LXT2</accession>
    <name>A0A8C2LXT2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15">Syncytin b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Synb</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Proc. Natl. Acad. Sci. U.S.A." volume="102" first="725" last="730">
            <title>Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae.</title>
            <authorList>
                <person name="Dupressoir A."/>
                <person name="Marceau G."/>
                <person name="Vernochet C."/>
                <person name="Benit L."/>
                <person name="Kanellopoulos C."/>
                <person name="Sapin V."/>
                <person name="Heidmann T."/>
            </authorList>
            <dbReference type="PubMed" id="15644441"/>
            <dbReference type="DOI" id="10.1073/pnas.0406509102"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="NP_001292147.1">
        <property type="nucleotide sequence ID" value="NM_001305218.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016833460.1">
        <property type="nucleotide sequence ID" value="XM_016977971.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LXT2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013280.1">
        <property type="protein sequence ID" value="ENSCGRP00001009104.1"/>
        <property type="gene ID" value="ENSCGRG00001011259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105349233"/>
    <dbReference type="KEGG" id="cge:105349233"/>
    <dbReference type="CTD" id="239167"/>
    <dbReference type="GeneTree" id="ENSGT00940000163436"/>
    <dbReference type="OMA" id="TRFCQGR"/>
    <dbReference type="OrthoDB" id="9838482at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000768">
        <property type="term" value="P:syncytium formation by plasma membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09851">
        <property type="entry name" value="HTLV-1-like_HR1-HR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.210:FF:000002">
        <property type="entry name" value="Syncytin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF83">
        <property type="entry name" value="SYNCYTIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678665" evidence="11">
        <location>
            <begin position="18"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038206386" description="syncytin b" evidence="15">
        <location>
            <begin position="18"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038206387" description="syncytin b" evidence="15">
        <location>
            <begin position="18"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038206390" description="syncytin b" evidence="15">
        <location>
            <begin position="419"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="NP_001292147.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M040</accession>
    <name>A0A8C2M040_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="15">1.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Aldh5a1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.24" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003502254.3">
        <property type="nucleotide sequence ID" value="XM_003502206.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265129.1">
        <property type="nucleotide sequence ID" value="XM_027409328.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M040"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016520.1">
        <property type="protein sequence ID" value="ENSCGRP00001012287.1"/>
        <property type="gene ID" value="ENSCGRG00001013734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764462"/>
    <dbReference type="KEGG" id="cge:100764462"/>
    <dbReference type="CTD" id="7915"/>
    <dbReference type="GeneTree" id="ENSGT00930000151038"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051932">
        <property type="term" value="P:synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000096">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="16">
        <location>
            <begin position="63"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003345"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU365091"/>
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        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012287.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027265129.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="56170" checksum="BC96ED1F71E0E380" modified="2022-01-19" version="1">MGTRFLLRSFWAARLALPPAGRRLRPASSEAQRRSYARGPAGLPADLLRGDSFVGGRWLPAPATFPVHDPASGATLGTVADCGVPEARAAVRAAHDAFCSWKGVSVKERSSLLRKWYDLMMENKDDLAKIITAESGKPLKEAQGEVLYSALFLEWFSEEARRIYGDIIYTSAKDKRGLVLKQPIGVAAIITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPYSALALAQLANQAGIPPGVYNVIPCSRTKAKEVGEALCTDPLVSKISFTGSTATGKVLLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNAGQTCVCANRFLVQRGIYDSFVKKFAEAMQKSLRVGNGFEEGITQGPLINEKAVEKVEKHVNDAVAKGAEVVTGGKRHQRGGNFFEPTLLSNVTKDMLCITEETFGPLAPVVKFDKEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEVKYVCYGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M053</accession>
    <name>A0A8C2M053_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Serine protease 55</fullName>
        </submittedName>
    </protein>
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        <name evidence="7 10" type="primary">LOC100753188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003498014.1">
        <property type="nucleotide sequence ID" value="XM_003497966.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027390680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M053"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015183.1">
        <property type="protein sequence ID" value="ENSCGRP00001010954.1"/>
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    </dbReference>
    <dbReference type="GeneID" id="100753188"/>
    <dbReference type="KEGG" id="cge:100753188"/>
    <dbReference type="GeneTree" id="ENSGT00940000156020"/>
    <dbReference type="OMA" id="GVGEFPW"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="P:binding of sperm to zona pellucida"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Serine proteinase stubble"/>
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    </dbReference>
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        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00089">
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    </dbReference>
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        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678687" evidence="5">
        <location>
            <begin position="16"/>
            <end position="321"/>
        </location>
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    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="35"/>
            <end position="266"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027246481.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35814" checksum="5429D36419C9FAEE" modified="2022-01-19" version="1">MILPSILLLVAHTLGANIECGVRPLYDGKIRYSRIIGGQEAEVGEFPWQVSIQEKGHHFCGGSIISEWWILTVAHCFYSDEISPLDLIVIAGSSDLTTASMEIQVANIIRHKNFQRLTMDNDIALLKLATPIYFNDMTVPICLPLHPTPPSWHECWVAGWGVTNSDDKRSMKTDLMKAPMHIIDWKECTKVFPKLTTNMLCASYGNESYDACQGDSGGPLVCNTEPGNKWYQVGIISWGRSCGKRGSPGIYTLLSNYTLWIEKIAQIEGKPLDAKPKRAAVKKKMRGRNQSSKCPALGYPQSWLLSCLLPCVLLRALSNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M1Q6</accession>
    <name>A0A8C2M1Q6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Junctophilin</fullName>
        </recommendedName>
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    <gene>
        <name evidence="13 16" type="primary">Jph2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetidae</taxon>
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            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the junctophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279303.1">
        <property type="nucleotide sequence ID" value="XM_027423502.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M1Q6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013716.1">
        <property type="protein sequence ID" value="ENSCGRP00001009500.1"/>
        <property type="gene ID" value="ENSCGRG00001011605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771806"/>
    <dbReference type="KEGG" id="cge:100771806"/>
    <dbReference type="CTD" id="57158"/>
    <dbReference type="GeneTree" id="ENSGT00940000159411"/>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
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        <property type="term" value="C:Z disc"/>
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        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
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        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055024">
        <property type="term" value="P:regulation of cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000003">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF26">
        <property type="entry name" value="JUNCTOPHILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037387">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="PIRNR" id="PIRNR037387"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009500.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027279303.1"/>
        </source>
    </evidence>
    <sequence length="688" mass="73514" checksum="3D9BD9631DBF6BC3" modified="2022-01-19" version="1">MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSALRTSLSSLRSEHSNGTVAPDSPAADGPVLPSPPVPRGGFALSLLATTEAARPPGLFTRGTLLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDTAAPFDADIDATTTETYMGEWKNDRRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRRVLPLKSNKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANHESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLDTPERGAGAGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPAASKDGLLSPGAWNGEPGGEGSRPVTPSDGAGRRSPARPVSEHMAIEALQPPPAPSREPEVAMYRGYHSYAVRTGPPEPPPLEDEPEPEASGSNSAPPSPSSATAPEEQPSAPRSLVPATPATLEPKPIVPKAEPKAKARKTEARGLSKVKKKGRKEVALAAEAEVEVEEVPNTVLICMVILLNIGLAILFVHLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M9A7</accession>
    <name>A0A8C2M9A7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15 18">Butyrophilin-like protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Btnl10</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. BTN/MOG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283170.1">
        <property type="nucleotide sequence ID" value="XM_027427369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M9A7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019609.1">
        <property type="protein sequence ID" value="ENSCGRP00001015368.1"/>
        <property type="gene ID" value="ENSCGRG00001015992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762433"/>
    <dbReference type="KEGG" id="cge:100762433"/>
    <dbReference type="CTD" id="192194"/>
    <dbReference type="GeneTree" id="ENSGT00940000158017"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05713">
        <property type="entry name" value="IgV_MOG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000208">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF133">
        <property type="entry name" value="BUTYROPHILIN-LIKE PROTEIN 10 PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678793" evidence="12">
        <location>
            <begin position="31"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="13">
        <location>
            <begin position="285"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007591"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023319"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50188"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015368.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027283170.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="54495" checksum="76402E7B96FAF1E1" modified="2022-01-19" version="1">MARPHHGDAATLPSFLVTFIFLQLLPAGNGKSDFRVLGPPDPLLAIFGQDKELLCKLSPNISAEGMELRWYRDQPSTAVHVHKNGEDVYEEQMVEYRGRTTFVGNHMVRGEAAVRINNVSMFDNGTYHCVFKEHTSYSQATLWLKVAGLGSSPRIHVTDTQDKRIRAECTSTGWFPEPKVEWLDLRGQPVPAETHFSATASTGLLTVVSIVTTKDRAVEGLTCSITNPLLPEKKVAETYLPASLFRMPLSAERVPVLPLILAALGLVTAAIACAFGRRHKEDKSEEEEEVDPRASAEVEPFHDSLSLDPETSSPKLVVSENQKSVKRLLFDQDLSPSSKRFDQDPCILAQEQFDAGRHYWEVEVGDRRAWILGVCLESLGREGRIPKSPQHGLWALEFYKKKLQALSYPRTHLSLPQPICRVGIFLDFEAGKISFHNAVNGSLIYVFSGLSFSGPLQPFFCLWTHDPRPLTICSVVRETEEVTDSSEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MAC2</accession>
    <name>A0A8C2MAC2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15 18">Transmembrane protein 131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Tmem131</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM131 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027242651.1">
        <property type="nucleotide sequence ID" value="XM_027386850.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001019272.1">
        <property type="protein sequence ID" value="ENSCGRP00001015033.1"/>
        <property type="gene ID" value="ENSCGRG00001015747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771946"/>
    <dbReference type="KEGG" id="cge:100771946"/>
    <dbReference type="CTD" id="23505"/>
    <dbReference type="OrthoDB" id="168404at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032964">
        <property type="term" value="P:collagen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055435">
        <property type="entry name" value="Ig_TMEM131L_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055436">
        <property type="entry name" value="Ig_TMEM131L_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045695">
        <property type="entry name" value="TMEM131-like_Ig_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056311">
        <property type="entry name" value="TMEM131_Ig_2"/>
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    <dbReference type="InterPro" id="IPR055437">
        <property type="entry name" value="TMEM131L_Ig_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022113">
        <property type="entry name" value="TMEM131L_N"/>
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    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_TMEM131_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_TMEM131L_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_TMEM131L_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24499">
        <property type="entry name" value="Ig_TMEM131L_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_TMEM131L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12371">
        <property type="entry name" value="TMEM131_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1117"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 131-like N-terminal" evidence="9">
        <location>
            <begin position="108"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131 second Ig-like" evidence="11">
        <location>
            <begin position="208"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 131-like second Ig-like" evidence="10">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L third Ig-like" evidence="12">
        <location>
            <begin position="435"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L fourth Ig-like" evidence="13">
        <location>
            <begin position="835"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L fifth Ig-like" evidence="14">
        <location>
            <begin position="1022"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1587"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1763"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1831"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1210"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1244"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1325"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1348"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1375"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1419"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1432"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1506"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1537"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1598"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1608"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1674"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1767"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1831"/>
            <end position="1843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006682"/>
        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
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            <dbReference type="Pfam" id="PF12371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24495"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24498"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015033.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027242651.1"/>
        </source>
    </evidence>
    <sequence length="1877" mass="204872" checksum="4E00FF03FDBA4A86" modified="2022-01-19" version="1">MGKRAGGGGAAATATASASSGAGLEPAAGRGGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFIQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFKPVTLKASESKYTKVASISFDASRAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIQDSPADPVERPIYLTNTFSFAILIHDVLLPEEARTMFKVHNFSKPVLILPNESGYIFTLFFMPSTSSMHIDNNILLVTNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGVLSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVATERGNRTTVIASLPELERSSLPDQSPVTLASGHFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHMVLPPSFPGKIVHQSLNIMNSFSQKVKIQHIRSLSEDVRFYYKRLRGNREDLEPGKKSKIANIYFDPGLQCGDHCYIGLPFLSKSEPKVQPGVAMQEDLWDADWDSHQSLFKAWMGIKENAGHRLNAMFEVNTDLQKNIVSKITAELSWPSILSSPRHVKFPLTNTNCSSEEEITLENPADVPVYVQFIPLALYSNPSIFVDKLISRFNLSKVAKLDLRTLEFQVCRNSAHPLQSPTGFTEGLSRHYILNLILKPGEKKSVKVKFTPLHNRTVSSLIIVRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCLDSLKLREPNFTLKRTFKVENTGQLEIHVETIEISGYACEGYGFKVVNCQEFALSANTSRDIIILFTPDFTASRVIRELKFVTTSGSEFVFVLNASLPYHMLAACAEALPRPNWELALYIIISGVMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIAGISSEGNLNTLGCEHSHGRGFYSSSSSRPGTGSHRQCGTSVHPHSSHSSKTSADVDSVRTKNSSSMSNRTSAQAATSQSTSKTSPLVLEANAVSQSHTASRKSKGSKQSQHSSQHHGHSPLEQHSQPPPPVPQHQEPPSERLSPAPLTHSSHPERASNTRHSSEDSDITSLIEAMDKDFDHHDSPSLDVFTEQPPSPLSKSKGKGKSLQQRKTKPPKKQEEKEKRGKGKPQEDELKDTLADDDSSSTTTETSNPDTEPLLREDTEKQKGKQAMPEKHEGEMSQVKQKSKKLLNVKKEIPADVKGSSFELPYTPSLENKQRRNLPTKIPLPATLTSGSKSRNSQKTKGTNKLVDSRPVALSKFLPSSQELGNTSSSEGEKDSPPPEWDAVPVHKPSSSTDSLYKLSLQTLNADIFLKQRQTSPTPASPSPPTAPCPFTTRGSYSSIVNSSSSDTKAKQPNGSKSKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKISSSKSDFSSSLGISHIPVDSDGSDSSGLWSPISNPSSPDFTPLNSFSAFGNSFNLTGVFSKLGLPRSCSQSSQRSWNEFSSGPSYLWDSPATDPSPSWPANSSSPTHTATSVLGSASGLWSTTPFSSSIWSSNLNSALPFTTPTNTLASIGLMGTENSTTAHAPSASSPADDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MC09</accession>
    <name>A0A8C2MC09_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Stk39</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027276057.1">
        <property type="nucleotide sequence ID" value="XM_027420256.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MC09"/>
    <dbReference type="SMR" id="A0A8C2MC09"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020793.1">
        <property type="protein sequence ID" value="ENSCGRP00001016549.1"/>
        <property type="gene ID" value="ENSCGRG00001016830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762055"/>
    <dbReference type="KEGG" id="cge:100762055"/>
    <dbReference type="CTD" id="27347"/>
    <dbReference type="GeneTree" id="ENSGT00940000154621"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019870">
        <property type="term" value="F:potassium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071476">
        <property type="term" value="P:cellular hypotonic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035865">
        <property type="term" value="P:cellular response to potassium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038146">
        <property type="term" value="P:chemokine (C-X-C motif) ligand 12 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030644">
        <property type="term" value="P:intracellular chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042116">
        <property type="term" value="P:macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036438">
        <property type="term" value="P:maintenance of lens transparency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090188">
        <property type="term" value="P:negative regulation of pancreatic juice secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901380">
        <property type="term" value="P:negative regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902306">
        <property type="term" value="P:negative regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900745">
        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010820">
        <property type="term" value="P:positive regulation of T cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070294">
        <property type="term" value="P:renal sodium ion absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904044">
        <property type="term" value="P:response to aldosterone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002021">
        <property type="term" value="P:response to dietary excess"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000043">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000114">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000068">
        <property type="entry name" value="STE20/SPS1-related proline-alanine-rich protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF14">
        <property type="entry name" value="STE20_SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="72"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="370"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027276057.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="60083" checksum="A1EAAE040F616796" modified="2022-01-19" version="1">MAEPSGSPVHVQLPQQAAPVTAAAAVAAPAAATSAPAPAPAAPAAPAPAPAAAPASAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENPEISVNAGGIHEQIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MCQ5</accession>
    <name>A0A8C2MCQ5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RIKEN cDNA 0610040J01 gene</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein C4orf19 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">CUNH4orf19</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035308422.1">
        <property type="nucleotide sequence ID" value="XM_035452531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MCQ5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020701.1">
        <property type="protein sequence ID" value="ENSCGRP00001016457.1"/>
        <property type="gene ID" value="ENSCGRG00001016782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769651"/>
    <dbReference type="KEGG" id="cge:100769651"/>
    <dbReference type="CTD" id="55286"/>
    <dbReference type="GeneTree" id="ENSGT00390000013778"/>
    <dbReference type="OrthoDB" id="8773301at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031528">
        <property type="entry name" value="C4orf19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16106">
        <property type="entry name" value="CHROMOSOME 4 OPEN READING FRAME 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16106:SF3">
        <property type="entry name" value="CHROMOSOME 4 OPEN READING FRAME 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15770">
        <property type="entry name" value="DUF4699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035308422.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34310" checksum="90F78BD1DF5DEF1A" modified="2022-01-19" version="1">MGCRCCKMIHSYLFDPVQVPSPGFVNEVNNCKLDEDDTVRLKGTQNSEAEVPRNALHGESLTNTENRDGTAGLPHQRSLPQEDSEERHCVEKHGIVNGISPTATLHLVRSPRPHQVDSGSWASSPWEGTIDSTHPAQPFLEEEDCRKQSCMVPTSEETQMVAHGDFKAPAEVLAAADHVLHIPAPDYPQLWNPTVDNADPAEKDYLFENHPEVESLPGIHPRMSEQGLSLPFSLKRSWDSLNEAVTTEVLNVYFKEEGPTHPTSVVDSRNEQEVPHPYNGDRDGVVDEDAEVAEALAALEAATAGEDADEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MFR0</accession>
    <name>A0A8C2MFR0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase 7</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Deubiquitinating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Herpesvirus-associated ubiquitin-specific protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin thioesterase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ubiquitin-specific-processing protease 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Usp7</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 29">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_027279720.1">
        <property type="nucleotide sequence ID" value="XM_027423919.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MFR0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022438.1">
        <property type="protein sequence ID" value="ENSCGRP00001018194.1"/>
        <property type="gene ID" value="ENSCGRG00001018007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769056"/>
    <dbReference type="KEGG" id="cge:100769056"/>
    <dbReference type="CTD" id="7874"/>
    <dbReference type="GeneTree" id="ENSGT00940000156053"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03772">
        <property type="entry name" value="MATH_HAUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000057">
        <property type="entry name" value="Putative ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000064">
        <property type="entry name" value="Putative ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="23">
        <location>
            <begin position="68"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="24">
        <location>
            <begin position="214"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027279720.1"/>
        </source>
    </evidence>
    <sequence length="1102" mass="128302" checksum="842598F3F4D3B455" modified="2022-01-19" version="1">MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHSNAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDDKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGDKASGRLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLITVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MGS7</accession>
    <name>A0A8C2MGS7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100762745</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003509145.1">
        <property type="nucleotide sequence ID" value="XM_003509097.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267444.1">
        <property type="nucleotide sequence ID" value="XM_027411643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MGS7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019753.1">
        <property type="protein sequence ID" value="ENSCGRP00001015510.1"/>
        <property type="gene ID" value="ENSCGRG00001016106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762745"/>
    <dbReference type="KEGG" id="cge:100762745"/>
    <dbReference type="OMA" id="SIFGGME"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15234">
        <property type="entry name" value="7tmA_OR7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027267444.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34917" checksum="74B8FC3A54288EBA" modified="2022-01-19" version="1">MELQNQTSHSEFHLLGLTDNRKLLPLIFTMFLSIYLITVLGNMLIILAISSGTQLHTPMYLFLSVLSINDICYSTVTIPKMLVNIQAQDDSISYTECLSQICFVSIFGGMENFLLAVMAYDRYVAICKPLRYTIIMNPFCCVLMVLFSLFLSIMDALLHSLMVLRLSFCTELEIPHFFCELAQIIKLACSDTFLNNFLIFVAAFVFGGGPVCGIIFSYIYIVSSVLKMTSSGGNHRAFSTCASHLSVVSLFYGTGFGVYISSAVTDSLKNTAMASMMYSVVPPLLNPFIYSLRNREMKEALRKLVGRFIFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MKW2</accession>
    <name>A0A8C2MKW2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8 11">Rho guanine nucleotide exchange factor 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Arhgef19</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
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        </source>
    </evidence>
    <sequence length="700" mass="76505" checksum="A3B1182C7E722504" modified="2022-01-19" version="1">MEEKPGQPQPQHHHSHHHPHHHPQQQQQQQQQQQQQQQSSHHHHHYYFYNHSHNHHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHTLQQHQETPKKKTGYGEINGNAGEISLKSLSSDEATNPISRVLNGNQQVVDPSLKQTVKTSTFGKAGIKTKNFIQKNSMDKKNGKSYENKSGENQAIDKNDVAIPNGVITNNSAYITNGYMGKGADNDGSGSESGYTTPKKRKARRNSAKGCENLNLVQDKIMQETGVPALKQGLESLKPDYSEQKGTRADGSKPIWKYETGPGGTSRGKPAVGDTLRKSSDIKPGLSSKKFDDRPKGKHASAAASKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKTVQNSSVSPSSSSSSSLSTGETQTQSSSRLSQVPMSALKSVTSANFSNGPVLAGTDGNVYPSGGQPLLTTAASTLTPISTGTDSVLQDISLTSAAVEQIKSSLFIYPSNMQTVLLSTAQVDLPSQTDQQNLGDIFQNQWGLSFINEPSAGPETVTGKSSDLKVMEVTFQGEYPATLVSQGAEIIPSGTEHPVFPKAYELEKRTSPQVLGNILKPGTTESGALSLEPSHIGDLQKADTSSQGALVFLSKDYEIENQNPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRAAIVYHTKEMESIWNLQKQDPKRIITYNEAMDSPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MV89</accession>
    <name>A0A8C2MV89_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RILP-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Rab-interacting lysosomal-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Rilpl1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts (when S-nitrosylated) with GAPDH. Interacts with RAB8A; interaction is dependent on the phosphorylation of 'Thr-72' of RAB8A. Interacts with RAB10 and RAB12; the interaction is dependent on the phosphorylation of 'Thr-73' of RAB10, and 'Ser-105' of RAB12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RILPL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003510308.3">
        <property type="nucleotide sequence ID" value="XM_003510260.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269706.1">
        <property type="nucleotide sequence ID" value="XM_027413905.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MV89"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028742.1">
        <property type="protein sequence ID" value="ENSCGRP00001024496.1"/>
        <property type="gene ID" value="ENSCGRG00001022398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773536"/>
    <dbReference type="KEGG" id="cge:100773536"/>
    <dbReference type="CTD" id="353116"/>
    <dbReference type="OrthoDB" id="10069524at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003382">
        <property type="term" value="P:epithelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903445">
        <property type="term" value="P:protein transport from ciliary membrane to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1770:FF:000002">
        <property type="entry name" value="RILP-like protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF6">
        <property type="entry name" value="RILP-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="17">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="18">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="77"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027269706.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="47252" checksum="87AB97BF501DC1FE" modified="2022-01-19" version="1">MEEPLGSPPAALSALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCEAIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRVERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLNHKDVGFSEEEFQKQEGMSERERQVMKRLKEVVDKQRDEIRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEAEIQLQADGEECLSDSEKAALDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEIEEENRIPQPPPIIHPRTSPQPESGIKRLFSFFSRDKKRLTNTQRPTHIHESFGQWANTHRDDGYTEQGQEALQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MXL7</accession>
    <name>A0A8C2MXL7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidoreductase NAD-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8 9" type="primary">Oxnad1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8 9">17A/GY</strain>
            <tissue evidence="8 9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003495352.1">
        <property type="nucleotide sequence ID" value="XM_003495304.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007633148.1">
        <property type="nucleotide sequence ID" value="XM_007634958.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245305.1">
        <property type="nucleotide sequence ID" value="XM_027389504.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245306.1">
        <property type="nucleotide sequence ID" value="XM_027389505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MXL7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027967.1">
        <property type="protein sequence ID" value="ENSCGRP00001023721.1"/>
        <property type="gene ID" value="ENSCGRG00001021866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768576"/>
    <dbReference type="KEGG" id="cge:100768576"/>
    <dbReference type="CTD" id="92106"/>
    <dbReference type="GeneTree" id="ENSGT00390000004280"/>
    <dbReference type="OMA" id="WIDFFIP"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00410">
        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027245305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027245306.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33928" checksum="ACC5C86FF5A0DBD6" modified="2022-01-19" version="1">MAHAVFIPGLSRGTALWRLTASTLRHLTLTSIMKSKRKTDHLERTASALRREVVASAKVCEIAHESPTVKSLRLLVADKAFSFKAGQWVDFFIPGVSVVGGFSICSSPQLLEQERMIELAVKYTNHPPAIWVHNKCTLDSEVALRVGGEFFFDPQPTEAPRNLVLIAGGVGINPLLSILRHSADLHRDQANKGSSYEIGKIKLFYSAKNTSELLFKKNILDLVNEFPEKITCSLHVTKQTAQISEELKPYITEGRITEKEISNHVSAGTLFYICGPPPMTDFFSKQLEDSHVPKEHICFEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N3U2</accession>
    <name>A0A8C2N3U2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Serine/threonine-protein kinase PINK1, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Serine/threonine-protein kinase Pink1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31 34" type="primary">Pink1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="33" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
            <tissue evidence="34">Liver</tissue>
        </source>
    </reference>
    <reference evidence="31" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="26">Upon mitochondrial depolarization, it forms a supercomplex with TOM and TIM23 complexes. PINK1-TOM-TIM23 supercomplex formation requires PINK1 interaction with TOMM20 and TOMM70 and is critical for PINK1 stabilization at the outer mitochondrial membrane, kinase activation and downstream mitophagy. Upon mitochondrial depolarization, interacts with TIMM23; the interaction is required for PINK1 accumulation at the outer mitochondrial membrane, kinase activation by autophosphorylation and PRKN recruitement to mitochondria. Interacts with PRKN. Interacts with FBXO7. Forms a complex with PRKN and PARK7. Interacts with NENF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027255598.1">
        <property type="nucleotide sequence ID" value="XM_027399797.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310741.1">
        <property type="nucleotide sequence ID" value="XM_035454850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N3U2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032104.1">
        <property type="protein sequence ID" value="ENSCGRP00001027856.1"/>
        <property type="gene ID" value="ENSCGRG00001024734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757303"/>
    <dbReference type="KEGG" id="cge:100757303"/>
    <dbReference type="CTD" id="65018"/>
    <dbReference type="GeneTree" id="ENSGT00390000001206"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097449">
        <property type="term" value="C:astrocyte projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055131">
        <property type="term" value="F:C3HC4-type RING finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043422">
        <property type="term" value="F:protein kinase B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014046">
        <property type="term" value="P:dopamine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072655">
        <property type="term" value="P:establishment of protein localization to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072656">
        <property type="term" value="P:maintenance of protein location in mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099074">
        <property type="term" value="P:mitochondrion to lysosome vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902902">
        <property type="term" value="P:negative regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903384">
        <property type="term" value="P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903298">
        <property type="term" value="P:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090258">
        <property type="term" value="P:negative regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000378">
        <property type="term" value="P:negative regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903852">
        <property type="term" value="P:positive regulation of cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033603">
        <property type="term" value="P:positive regulation of dopamine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902958">
        <property type="term" value="P:positive regulation of mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="entry name" value="PTEN induced kinase 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL"/>
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    <keyword evidence="20" id="KW-0072">Autophagy</keyword>
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    <keyword evidence="13 34" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="156"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <sequence length="580" mass="63327" checksum="02090679FE72BFD6" modified="2022-01-19" version="1">MAVRQALGRGLQLGRALLLRFAAKPGPISGLGRPGPAAAWGRGERPGRAAGPRAQPGPLGLPLPDRYRFFRQSVAGLAARIQRQFVVRARGGAGPCGRAAFLAFGLGLGLIEEKQAEGRRAASACQEIQAIFTQKNKLVSDPLDTRHWQGFRLEDYLIGQSIGKGCSAAVYEATMPTLPQHLEKAKCVSLLKKGPDVLPKGADREQAPRAPAFPFAIKMMWNISAGSSSEAILSRMSQELVPASRVALDGEYGGVTYRRPRGGPKQLAPHPNIIRVFRAFTSSVPLLPGALADYPDVLPPSFHPEGLGHSRTLFLVMKNYPCTLRQYLQEHTPSPRLATMMTLQLLEGVDHLVQQGIAHRDLKSDNILVELDSDSCPWLVISDFGCCLADEHIGLQLPFTSWYVDLGGNGSLMAPEVSTAHPGPRTVVDFSKADTWAVGAIAYEIFGLANPFYGQGRAHLESRSYQEAQLPEMPKSVPPDARQLVRSLLQREASKRPSARVAANVLHLSLWGEHLLALKNLKLDKMIGWLLQQSAATLLADRLMEKSSVETKLQMLFLANLEWEALCQAALLLRSWRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N5H0</accession>
    <name>A0A8C2N5H0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2</fullName>
            <ecNumber evidence="4">1.14.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysyl hydroxylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Plod2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[collagen] + 2-oxoglutarate + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16569"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:12752"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:133442"/>
            <dbReference type="EC" id="1.14.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Rough endoplasmic reticulum membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.11.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_016833590.2">
        <property type="nucleotide sequence ID" value="XM_016978101.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266745.1">
        <property type="nucleotide sequence ID" value="XM_027410944.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N5H0"/>
    <dbReference type="SMR" id="A0A8C2N5H0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029512.1">
        <property type="protein sequence ID" value="ENSCGRP00001025266.1"/>
        <property type="gene ID" value="ENSCGRG00001022906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762939"/>
    <dbReference type="KEGG" id="cge:100762939"/>
    <dbReference type="CTD" id="5352"/>
    <dbReference type="GeneTree" id="ENSGT01030000234558"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008475">
        <property type="term" value="F:procollagen-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046947">
        <property type="term" value="P:hydroxylysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000004">
        <property type="entry name" value="Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000140">
        <property type="entry name" value="Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="32"/>
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    <feature type="chain" id="PRO_5044679156" description="Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2" evidence="20">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QGR8</accession>
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    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_007632089.4"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027401700.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSCGRP00001011051.1"/>
        <property type="gene ID" value="ENSCGRG00001012796.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:leukocyte proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of chemokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of interleukin-6 production"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of interleukin-8 production"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="7tm_1"/>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="8 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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            <begin position="23"/>
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            <begin position="90"/>
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            <begin position="146"/>
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    <sequence length="395" mass="44215" checksum="89969DD0E94D82BB" modified="2022-01-19" version="1">MRSLSLAWLLGGVILLAASVSCNRTVQGRNGKGRSIIGRLNTPPPISGEGVTVEPGFSIDEFSTSVLTGKMTTVFLPVIYTIVFVIGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHLHGNNWIYGGAFCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKTNIAIGVSLAIWLLIFLVTIPLYVMKQTIYIPALNITTCHDVLPEEVLVGDMFNYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRQRAIRLIVTVLAMYFICFTPSNLLLVVHYFLIKSQGQSHVYALYLVALCLSTLNSCIDPFVYYFVSQDFRDHAKNALLCRSVRTVKRMQVSLTSNKFSRKSSSYSSSSTSVKTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EW05</accession>
    <name>A0A9J7EW05_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">[histone H3]-lysine(9) N-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.367</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Ehmt2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60280"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.367"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60284"/>
            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.367" evidence="18"/>
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        <property type="nucleotide sequence ID" value="XM_027388786.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100769417"/>
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    <dbReference type="OrthoDB" id="5792673at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140948">
        <property type="term" value="F:histone H3K9 monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20905">
        <property type="entry name" value="EHMT_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10533">
        <property type="entry name" value="SET_EHMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000005">
        <property type="entry name" value="Euchromatic histone-lysine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000029">
        <property type="entry name" value="histone-lysine N-methyltransferase EHMT1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047762">
        <property type="entry name" value="EHMT_CRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038034">
        <property type="entry name" value="SET_EHMT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21533">
        <property type="entry name" value="EHMT1-2_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 19" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="736"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="836"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="902"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="22">
        <location>
            <begin position="1024"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="21">
        <location>
            <begin position="1090"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="334"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="599"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027244587.1"/>
        </source>
    </evidence>
    <sequence length="1262" mass="137715" checksum="98B11999F8BBD47F" modified="2023-06-28" version="1">MRGLPRGRGPMRARGRGXSGPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGLTGPPVPCVPSQGEAPAEMGALLLEKEPRGTAERALGPLGDAPRSEDTLPKADPDSLEPAGPSSPASVTVTVGDEGADTPAGAAPLLGDEPESLEGDGGRVLLGHATKSFPSSPSKGGACPSRAKMSVTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPPPATTTGQEGQPKVHRARKTMSKPGSGQPPVPEKRPPEVQHFRMSDDMHSLGKVTSDAAKRRKLNSGSLSEDFGSARGSGDVTLEKGEPRPLEEWEAVVGDGFSLYYDSYSVDERVDSDSKSEVEALAEPLSEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRTKEPRGVNGVGSTGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFDELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPAGTAAPAPLPLAQDAPGRADTSQPSARMRGHGEPRRPPCDPLTDTIDSSGPSLTLPNGSCLSAVGLPPGPGREALEKALVIQESERRKKLRFHPRQLYVSVKQGELQKVILMLLDNLDPNVQNDQQSKRTPLHAAAQKGFVEICHVLLQAGANINAVDKQQRTPLMEAVVHNRLEVARYMVQLGGCVYSKEEDGSTCLHHAAKMGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCADDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPELSALPPINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZF8</accession>
    <name>A0A9J7EZF8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">E3 ubiquitin-protein ligase ZNRF3</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Kringle-containing protein marking the eye and the nose</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">RING-type E3 ubiquitin transferase ZNRF3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Zinc/RING finger protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">LOC100772745</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="33" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
            <tissue evidence="34">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZNRF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027243170.1">
        <property type="nucleotide sequence ID" value="XM_027387369.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100772745"/>
    <dbReference type="KEGG" id="cge:100772745"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000050">
        <property type="term" value="P:regulation of non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072089">
        <property type="term" value="P:stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16799">
        <property type="entry name" value="RING-H2_ZNRF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000018">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000041">
        <property type="entry name" value="Kremen protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.20.10:FF:000006">
        <property type="entry name" value="Kremen protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000075">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase rnf43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040700">
        <property type="entry name" value="ZNRF-3_ecto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051073">
        <property type="entry name" value="ZNRF3_Arkadia_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045903">
        <property type="entry name" value="ZNRF3_Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16200">
        <property type="entry name" value="RING ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18212">
        <property type="entry name" value="ZNRF_3_ecto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 25" id="KW-0420">Kringle</keyword>
    <keyword evidence="17 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 26" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="1265"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="31">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="30">
        <location>
            <begin position="903"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="32">
        <location>
            <begin position="988"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="29">
        <location>
            <begin position="1086"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="600"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="633"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00056485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00069169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00077187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="RefSeq" id="XP_027243170.1"/>
        </source>
    </evidence>
    <sequence length="1345" mass="146817" checksum="BEF38A8BA72D2D74" modified="2023-06-28" version="1">MRPRSGGRPGAPGRRRRRLRRGPAVVACRRRAXPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRFSRAGAMLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSGSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPGAVCVETSNLTRGRQPRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQNLYSPQTPTYIRGYPPLHLDHTLAPHRCSLEHRAYSPAHPFRRPKFSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQPIPSLTPRGPSRAFPPSGGSSLLFPTVVHMAPPTHVESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSNSSGQCRCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRGPAVHLEGSPPPEELPAAHSQGAGRGEPWLGPASPSGDQLSTCSLEMNYSSNSSLEPRGPNSSTSEVGLEVSPGAALDLRRTWKGGPEGPSCGCCFDPQPSSLGHGTGAAAGGSTLFLGPRLREDCNPTSGEPQPGSSQGLYGLHSDHFPRTDGVKYEGLPCCFYEEKQVAHSAGRGNGCYTEDYSVSVQYTLTEEPPPSCYAGARDLSQRIPIIPEDVDCDLGLPQDCQGMHSHSSWGGMLGLDVSRLHWSLGTTREEEQAPCCQAEVPLQPGCSPEEADASRASLSIAPQDTQESHALAAEASECFTANGADYRGTQSWTALQGGKPCLFWNETFQHPYNTLKYPNGEAGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCDIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKHGEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMAAVVYSPDFPDTYATGRVCYWTIRVPGASHIHFNFTLFDIRDSADMVELLDGYTHRVLVRFNGRNRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQATKEEPPQERPAVNQTLAEVITEQANLSISAAHSSKVLYVITTSPNHPPQTVPGSHSWAPSVGASGHRVEGWTVYGLATLLILTVTAIVAKILLHVTFKSHRVPASGDLRDCRQPGASGEIWTIFYEPSTTISIFKKKLKGQSQQDDRNPLVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F1V5</accession>
    <name>A0A9J7F1V5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRPM8 channel-associated factor 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100753518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003504406.2">
        <property type="nucleotide sequence ID" value="XM_003504358.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245585.1">
        <property type="nucleotide sequence ID" value="XM_027389784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F1V5"/>
    <dbReference type="GeneID" id="100753518"/>
    <dbReference type="KEGG" id="cge:100753518"/>
    <dbReference type="OrthoDB" id="10260387at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.30:FF:000001">
        <property type="entry name" value="TRPM8 channel-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.80:FF:000001">
        <property type="entry name" value="TRPM8 channel-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.80">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051244">
        <property type="entry name" value="TCAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15730">
        <property type="entry name" value="EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15730:SF1">
        <property type="entry name" value="TRPM8 CHANNEL-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="542"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027245585.1"/>
        </source>
    </evidence>
    <sequence length="921" mass="102523" checksum="B0595471EDF86B74" modified="2023-06-28" version="1">MATPSAAFEALMTGVTSWDIPEDAIPCELLLIGESSFPVMVNDMGQVLIAASSYGRGRMVVVAHEDYLVESQLFVFLVNAIGWLRSSPESSIGIHTSLSPLVKILESCGIESTIEPEANDSIGVYCIDAYHESMSDKLVQFVKRGGGLLIGGQAWDWANQGEDERILFTFPGNLVTSVAGVYFTDNKADSTVFKVSKKMPKIPVLVSCEDDLSEDRDELLHGISELDITNSDCFPSQLLVHGALAFPLGLDTYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGKIVVQTELRTLSGLLAVGGIDTSIEPQLTSDASVYCFEPTSDVGVKELQEFVAEGGGLFVGAQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKLGIRTYHFRSTLAEFEVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRENPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMHSSLYLRPSESPITVDVNCTNRGTRYCWMSTALYIPGRQIIEVSLPEDAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLDKPVKSITCLWGGLLYIIVPQNSKLGSVPITVKGAVRAPYYKLGETSQEEWKRRLQEHPGPWGELATDNLILTVPTANLRALENPEPLLRLWDDVMQAVARLGGEPFPLRLPQRIVADVQISVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCNLWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNIKNWNAWTALETYLQLQEAFGWEPFIRLFTEYRNQTNLPTDTADKMNLWAKMFSQQVQKNLAPFFEAWAWPIQKELATSLAYLPEWKENIMKLYLLTQMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F2A0</accession>
    <name>A0A9J7F2A0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine-protein phosphatase non-receptor type 12</fullName>
            <ecNumber evidence="8">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Ptpn12</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="8"/>
    <dbReference type="RefSeq" id="XP_027249253.1">
        <property type="nucleotide sequence ID" value="XM_027393452.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F2A0"/>
    <dbReference type="GeneID" id="100758766"/>
    <dbReference type="KEGG" id="cge:100758766"/>
    <dbReference type="CTD" id="5782"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14604">
        <property type="entry name" value="PTPc-N12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012266">
        <property type="entry name" value="PTN12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047170">
        <property type="entry name" value="PTN12/18/22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047251">
        <property type="entry name" value="PTN12_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983">
        <property type="entry name" value="TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000932">
        <property type="entry name" value="Tyr-Ptase_nr12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027249253.1"/>
        </source>
    </evidence>
    <sequence length="776" mass="86899" checksum="DAF63F4634AE1768" modified="2023-06-28" version="1">MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFRISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYELHGAQKIADSNEITTGNMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMVSSEQHSTDLNRNYSKPSDVTEKNESTVEHIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRAHAIKIKSASSSVVDKTSRPQELNLGDIKVDVPQNSCVDCGAAHSDRAPDSSEESPNSHTLSRPDRLPLDKKGHVTWSFHGPENATPVSDSSEGKSPDNHSQPVKTVSSTASSTTEVEARELVDPHNSSPVSGALLSFTNPLHSDDSDADEGDSDGAVTKSKTSISTASATVSAARSAESASTRKVLPMSIARQDLGGTLHSGAEKDVDVSEESPPPLPERTPESFVLASEHSTPVRSEWSELACQEWSGQIESEDLITSGNEKYDAGGIHIETCTDCPPTFSDKKNQVTESLTEATDIGFGNRCGKPKGPRDPPSEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F4Y3</accession>
    <name>A0A9J7F4Y3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rab11 family-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Rab-coupling protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Rab11fip1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homooligomer. Interacts with RAB11A, RAB11B, RAB25, RAB4A and RAB14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027251188.1">
        <property type="nucleotide sequence ID" value="XM_027395387.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F4Y3"/>
    <dbReference type="GeneID" id="100750840"/>
    <dbReference type="KEGG" id="cge:100750840"/>
    <dbReference type="CTD" id="80223"/>
    <dbReference type="OrthoDB" id="8956628at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010817">
        <property type="term" value="P:regulation of hormone levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08682">
        <property type="entry name" value="C2_Rab11-FIP_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000077">
        <property type="entry name" value="rab11 family-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2440:FF:000002">
        <property type="entry name" value="rab11 family-interacting protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037789">
        <property type="entry name" value="FIP_classI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746:SF22">
        <property type="entry name" value="RAB11 FAMILY-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746">
        <property type="entry name" value="RAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="651"/>
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        </location>
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            <begin position="995"/>
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        </location>
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            <begin position="171"/>
            <end position="187"/>
        </location>
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            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
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            <begin position="414"/>
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            <begin position="577"/>
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            <begin position="666"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00071490"/>
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            <dbReference type="ARBA" id="ARBA00078365"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50004"/>
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            <dbReference type="PROSITE" id="PS51511"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027251188.1"/>
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    <sequence length="1241" mass="133463" checksum="C075B9C5C2D57822" modified="2023-06-28" version="1">MSLAASAGRGLGTMWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPPLLSSGAAPAAAATLQLTVLHRALLGLDKFLGRAEVDLQELHRDQNRRKKQWYTLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSASDTASAIIPSTTPSVDSDEESFSKDKKKKSKIKTLFSKSNLQKTPLSQSMSVLPTSKLDKVLLHPGDLKSRWDDDDNEDESSSASDVMSHKRTPSADHTQLNQTKKEGLSFLGGLRSKNDSLSRSNLCINGNHVYMEQPEAKSEIKDSSPSNSPSPQGFRKKHLFSSTENLAARSPKEPGEGGGVTSDRRLSDSSSKDSVKSMSLPSYRPLTSGDSRESMSPANTEATKETKESKKQENKKSSLLSLVTGKKDVAKGSEGEPLPIVSEKEKERQGTSTEAQLREEDLGRKSERDVVPVASQWGNSLNPFEDVQISNPEASLESKSEPKPPVPAPRAPQTKAVKPRLEVPPKAQPKARLPSSDSAVFPTLPLSSPQAPIFSDMRGDSETQSSESPSASSSFSSPLAAPISTSTPIEHWPPTGKGEADPKEPPLLLKAVSQRESLTPALNTGSSVLGSPYKQLPIPVLKGTEESSGSETGAGKEAHSDESGKNPMGKPEELVTVPFPQQHHVPSPEEAQEVPPVLSLSSGRIANHAEKSPTGGNTDSEHQSRSFVENDHNGGVTSTVREATPPVREEEAASPFDSIAQKHEEMHPNARGGQKRVKKHVSFSEQLFVEEETEKLTRLEEEDEIHPQQLTQEGPVTGSMPDEESPECPHTEGTGEDPVTTAAQSIPSESDSFSEDPTSEASPGRGSAQFWRVEENDGLMTQYQSKASDHEGLLSDPLSDLPSASDVKSPVMSDLSFSLPSIPEVASDDERVDEAGDGGKAAKLEAGVSPGNVSPSSLEKAEGLSGRAHGSVLLENLHDFRSEAPRVAPSEQTAASGIPKSHLGKSSSVNKQSPGPGTVEEEEPKGSERPGSPLHISQGSPMPSPSPSATFPAAHSLPSSPYSDSHHTSVAEPPKKATEGSVAKVENFGKKKPLLQAWVTPSEIHPVSAQPNAGAEAAKHRLHPVKPMSTTAMKIANPGLGTAAIISENLINEAIIKKYQPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRVPTQLGKKAGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F5H1</accession>
    <name>A0A9J7F5H1_CRIGR</name>
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        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113832922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027247657.1">
        <property type="nucleotide sequence ID" value="XM_027391856.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="113832922"/>
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    <dbReference type="OrthoDB" id="9663166at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tmA_OR6C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF78">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="OLFACTORYR"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="38"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027247657.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35102" checksum="6F1E251A6C210D12" modified="2023-06-28" version="1">MRNLTVTTFVLLGLTDDPQLKTLIFIFLLLTYLLSITGNLTIISLIFIDSHLKTAMYFFLQNFSLLEISFTTACIPRYLYNISTGDKTITYNNCAIQIFFTDLFGVTEFFLLAIMSYDRYVAICKPLHYITIMNSKICKRLILCCWAAGLGVVLPPLSLGLNLKFCDSNVIDHFFCDASPLLKISCTDTWLIERLVIVCAVLTFIMTLVCVVLSYVYIIGTIIRFPSAQQRKKAFSTCSSHLIVVSITYGSCIFIYVKPSAKDSVAINKGVTVLTTSLAPMLNPFIYTLRNKQVKQAFNDSVKRLALFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F7S0</accession>
    <name>A0A9J7F7S0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Cytochrome P450</fullName>
            <ecNumber evidence="26">1.14.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC100761779</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.</text>
    </comment>
    <comment type="function">
        <text evidence="26">Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39759"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:76627"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:39760"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39755"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:76624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:39756"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + reduced [NADPH--hemoprotein reductase] + O2 = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:132256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:50297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an omega-methyl-long-chain fatty acid + reduced [NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56748"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:140991"/>
            <dbReference type="ChEBI" id="CHEBI:140992"/>
            <dbReference type="EC" id="1.14.14.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:56749"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24 26">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 26">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 26">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 25">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.-" evidence="26"/>
    <dbReference type="RefSeq" id="XP_027251521.1">
        <property type="nucleotide sequence ID" value="XM_027395720.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F7S0"/>
    <dbReference type="GeneID" id="100761779"/>
    <dbReference type="KEGG" id="cge:100761779"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102033">
        <property type="term" value="F:long-chain fatty acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20666">
        <property type="entry name" value="CYP2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000017">
        <property type="entry name" value="cytochrome P450 2U1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008069">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF364">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01686">
        <property type="entry name" value="EP450ICYP2D"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 24 25" id="KW-0349">Heme</keyword>
    <keyword evidence="14 24 25" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15 25" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="24">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00058812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU368047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027251521.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59992" checksum="5A67332709FADA92" modified="2023-06-28" version="1">MSSPGDPHPAAGEPPGAGPRLRAAGGALLLCGLAVLLGWVWLRRQRACGIPPGPAPRPLVGNIGHLLVPRFLRRQFWLGAGGQKDTDAVATHVRLARLAGVYGNVFSLFIGHRLVVVLSDFHSVREALVQQAEVFSDRPRMPLISIMTKEKGIVFAHYGAVWKQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKEEMQKHGDAPFSPFPIISNAVSNIICSLCFGQRFDYTNTEFKKVLDFMSRGLEICLHSQLFLINLCSWFYYLPFGPCKELRQIERDITCFLKNIIKEHQESLDASNPQDFIDMYLLHVEAERRASSSTSFSEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQKKVHEEIERVIGCDRVPSLTDKAQMPYTEATIMEVQRLSMAVPLAIPHMTSEKTVLQGYTIPKGTVVIPNLWSVHRDPAIWEKPDDFCPDRFLDDQGQLLKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFALPKGSEKPIMTGRFGLTLAPHPFNVTVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FB75</accession>
    <name>A0A9J7FB75_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurobeachin-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Nbeal1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007610116.1">
        <property type="nucleotide sequence ID" value="XM_007611926.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252812.1">
        <property type="nucleotide sequence ID" value="XM_027397011.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100768393"/>
    <dbReference type="KEGG" id="cge:100768393"/>
    <dbReference type="CTD" id="65065"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF115">
        <property type="entry name" value="NEUROBEACHIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1898"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2006"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2502"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1349"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1384"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1349"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1384"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027252812.1"/>
        </source>
    </evidence>
    <sequence length="2708" mass="308768" checksum="1133BE007CC8B083" modified="2023-06-28" version="1">MAARERLFELWMLYCTKKDPDYLRLWLDNFVLSYEQFLDVDFEKLPTRVDDVPPGISLLPDNILQVLRIQLLHCVQKTADGLEEQQQALSILLVKFFIILCRNLSNVEEIGTCSYINHVITMTTLYIQQLKSKKKEKEMADQTSIEEFVIHALAFCESLYDPYRNWRHRISGRILSSVEKSRQKYKPASLTVEFVPFFYQCFQESEHLKESLKCCLLHLFGAIVAGGQRNALQAISPATMEVLMRVLSDCDSWEEGDPEEVGRKRELTLKCLTQVVHILLTSSSDQRQVETSTILENYFKLLNSDHSALPKQRRSRRWESQFIALQIKMLNTITAMLDCADRPVLQAIFLNSNCFEHLIRLLQNCKLFLNAHSMVADKNEKDLANQLLTEISEDQVFQGRLDCLAVSSIQALTAVMKNSPAAKEVFKERIGYMHMFEVLKSLGQPSLELLKELMNMAVEGDHTSVGILGISNVHPLLVLIQWLPELESHDLQIFISDWLKKICCINKQSRTTCVNANMGIRIIETLESHSSLHRICAENLIAIHGSLGSQSVSSEEVRRLLRLLRVDESELIHPYTIPVTRAILTMARKLSFESALQYFNLSHSMAGISVPAIQKWPGSAFSFTAWFCLDQDQLTLGTTNQRGKRKQLYSFFTGSGMGFEAFITHSGMLVVAVCTKREYATVMLPDHSFCDSLWHNITIVHMPGKRPFGQSLVYIYDNGQQKVSAPLRFPAMNEPFTSCCIGSAGQRTTTPPPSQIPDPPFSTPITPHRTSFGGILSSASWGGTIEKSKSVSKLISAGTQDSEWGCPTSLEGQLGSVIVFHEALQPPQVKALYLAGPNCLSPWKCQDCDMADLPSSLLLQYTAKACKNSICLDLSTNCLHGRLTGNKVVNWDIKDIINCIGGLNVLFPLLEQISHLMEGQTSEGMNENTVNELITPIEQDCMALASTKASESRLEKNLVATFILIVKHFIQRHPINQDNLIQSHGVATLGALLQKVPGTLMDVNVLVAIQLLIEQVSLEKNTQLLQQMYQYLLFDFRIWNRGDFPFRIGHIQYLSTIIKDSRRVFRKKYGVQFLLDTLRIYYGHGCTCNELSPDDIRTIRTSLYGLIKYFLCKGGTHEEIQSIIGYIAATNEEEQLFGILDILFSLLRTSPTRGQLFLLMFEPGNADILYALLLNQKYSDKLREIIFKVMEQMLKCTNVYERSKQRIRLREVGYSGMGLLLNEAPVNTSLIKNLVNQIINADPVINFKDLLSVVYISHRTHVNVRVALCGKILQILQSQPDAAYQISQQVGWQDTFVKLFLKENFENVNSLHKHGKAVSVKENKNVSTEKLDDEKMTLADVSSDHWSLEDSQSLNSNTPLFQEDGSEGELSFKSENQEEFWHSNTSHLSLDLSGTDSCELSESGSQMPDSSPSTPSPVESIKSFSMRSDKERSITNEMDFSDDFLESQEGCEEELLQLLTNILNYVMSKGLEKSDEDTWIERGQVFSALTKPGISSELLRPSDEVKLILLQKMLEWAVTENRDAKSSPVTAENAFRLMLIIQDFLQSEGLVNSNVWTEKLLEDTTQLLDCLSVWYSETPVWVKLSQIQLQLLLEFIGRGSLQVCAVASAKLNALLQTKVIENQDEACFILGKLEHILNRSIKEQTEIYSFLIPLFRTLVSKIYELLFMNLHLPSLPFTNGSASFFEDFQEYCNSNEWQVYIEKYIVPYMKQYEVHTFYDGHEYMALYWKNCYEALMVNMHKRDREGGESKLKFQEYFVEPFNRKARQENLRYNNMIKQLSNQQLATFRRWKAIRLYLTCERGPWAERKQNQIHWKLANVENYSRMRLKLVPNYNFKTHEEASALRDNLGVQHLQPSSDSLLLEVVKQVKLSDMEEDKLELLEEDMIARVNIDEKEEQDQKEKLVLTEDCELITVIDIIPGRLEITTQHIYFHDNSIEKEDGIGFDFKWPHSQIREIHLRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKVYSRLLSLHSPNSYGTRSPQELFKASGLTQKWVNREITNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPTVFRDLSKPIGVVNEKNAKAMQEKYETFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNTYDVKELIPEFFYFPEFLENQNEFNLGYLQVSKELVNDVILPRWAKSPEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEVIQKQTKTEISTLNLFQHLPQLKSFFIEGISDGIPLLKAIIPKNQSRSFMSQGSPELLITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKAQRTVNGPFAPGLEITSKLFVVSHDAKLLFSAGHWDNSIQAMSLTKGKIVSHNIRHIDIVTCLATDYCGIHLISGSRDTTCMIWQITQQGGTPVGLASKPFQILYGHTDEILSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVCSSLEEKPTLKDKNMLHVFSVNGKYLGSQVLNEQISDICIIGEHVITGSLQGLLSIRELHSLNLSITPLAMRLPIHCVSVTKENSHVLVGLEDGKLIVVGVGKPAEMRSSQLSRKLWGSSKRLSQISAGETEYNTQDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FLP0</accession>
    <name>A0A9J7FLP0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: proto-oncogene FRAT1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Frat1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSK-3-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263123.1">
        <property type="nucleotide sequence ID" value="XM_027407322.2"/>
    </dbReference>
    <dbReference type="GeneID" id="103160455"/>
    <dbReference type="KEGG" id="cge:103160455"/>
    <dbReference type="CTD" id="10023"/>
    <dbReference type="OrthoDB" id="6381246at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008014">
        <property type="entry name" value="GSK3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35154">
        <property type="entry name" value="GBP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35154:SF1">
        <property type="entry name" value="PROTO-ONCOGENE FRAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05350">
        <property type="entry name" value="GSK-3_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027263123.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="34722" checksum="634406C7528759D7" modified="2023-06-28" version="1">MPCRREEEEEAGDEAEGEDDDDSFLLLQQSVTLGGSADVDRLIAQIGETLQLDAAHDGPASPSAAPGPPPPPPRVVAELPADKARAPARRLLRPSAPAEAGXPAPPGAVRCVLGERGRVRGRAAPYCVAELTAGAGALCPPPPQPGLEGPPVTGKPSTPQPFSGPCRRGWLRSAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLHAKLPAHPFLGPMSAPVHEPPSPGSPRAACSDPGDCRGGRGTELGTTFLSLAANNQGGHRTSLYLGTKGFTQDSTGLVEDSSLCKRDNKLRNTAEKSQIFSWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FS56</accession>
    <name>A0A9J7FS56_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tropomyosin alpha-1 chain isoform X7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Tpm1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027267075.1">
        <property type="nucleotide sequence ID" value="XM_027411274.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FS56"/>
    <dbReference type="GeneID" id="100770615"/>
    <dbReference type="KEGG" id="cge:100770615"/>
    <dbReference type="CTD" id="7168"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027267075.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28774" checksum="62DBA352072EADA5" modified="2023-06-28" version="1">MAGSSSLEAVRRKIRSLQEQADAAEERAGSLQRELDQERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDKFLCFIPSKTSSSSWMSHLSELCICLFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FVZ5</accession>
    <name>A0A9J7FVZ5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BUD13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Bud13</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027267860.1">
        <property type="nucleotide sequence ID" value="XM_027412059.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FVZ5"/>
    <dbReference type="GeneID" id="100773647"/>
    <dbReference type="KEGG" id="cge:100773647"/>
    <dbReference type="CTD" id="84811"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027267860.1"/>
        </source>
    </evidence>
    <sequence length="669" mass="76224" checksum="180C490C83BDA253" modified="2023-06-28" version="1">MAAALPLSKAEYLKRYLSGADAGPEGGPESVRKRRRKRPKPGGAGGKGMRIVDDDVGWAAISTTKPEKEEEEDGDLPVVAEFVDERPEEVKQMEAFRSSAKWRLLGDHSEDGHFHHDDQDPSPPRRVHRDTPDPSSPRRAHHDTPDPSPRRTCHDTPDPSPRRAHHDTPDPSPPRRAHHDTPDPSPRRARNDTPDPSPRRARNDTPDPSPRKARHDTPDPSPPRRARNDTPDPSPPRRARHDTPDPSPPRRSRHDSDTSPPRRVHHDSATSPPRKSHRNSSSVSPRRGHHGSSDISSPRRAHNHSPDTPQHRRTVDPSDPQHLRRPRHDSPDLELPRTKSSKAAERSCNKTVHQRGQEPSHPSVSKNSKYGRDSDLSPRKWQAKAHVGAKKQLDPKGVCQKSSDSDLSPPRQKQNSGHQDSDSDLSPPRNRQRHRSADSDLSPPRRRQRTKSSDSDLSPPRRSPRPGKKAAHMYSGAKTGLVTDVQREHQELKKQDQDTTTLGAQFEFAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKQKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLASKKAVEELAYKWSVEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FXZ8</accession>
    <name>A0A9J7FXZ8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transcriptional coactivator YAP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein yorkie homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Yes-associated protein YAP65 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Yap1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the YAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027270966.1">
        <property type="nucleotide sequence ID" value="XM_027415165.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FXZ8"/>
    <dbReference type="GeneID" id="100761993"/>
    <dbReference type="KEGG" id="cge:100761993"/>
    <dbReference type="CTD" id="10413"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000019">
        <property type="entry name" value="Putative transcriptional coactivator YAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000012">
        <property type="entry name" value="transcriptional coactivator YAP1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053819">
        <property type="entry name" value="TEADIR3_omega_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF9">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15238">
        <property type="entry name" value="TEADIR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="19">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="19">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="344"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027270966.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="53250" checksum="D89846E67E2D0EC5" modified="2023-06-28" version="1">MEPAQQPPPQPAPQGPVPPSAPAPPSGTPAAPPAPPAGHQVVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTVVSGPAATPAAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQLNVPTPASTAVPQTLMNSASGPLPDGWEQAMTQDGDVYYINHKNKTTSWLDPRLDPRFAMNQRITQSAPVKQPPPLAPQSPQGGVLGGGNSSQQQQMQLQQLQMEKERLRLKQQELLRQVRPQAIRNINPSTANAPKCQELALRSQLPTLEQDGGTQNAVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQSRFPDYLEAIPGTNVDLGTLEGDAMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G1N5</accession>
    <name>A0A9J7G1N5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpin B13 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Serpinb13</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family. Ov-serpin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016830853.1">
        <property type="nucleotide sequence ID" value="XM_016975364.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273669.1">
        <property type="nucleotide sequence ID" value="XM_027417868.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G1N5"/>
    <dbReference type="GeneID" id="100773018"/>
    <dbReference type="KEGG" id="cge:100773018"/>
    <dbReference type="CTD" id="5275"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19572">
        <property type="entry name" value="serpinB13_headpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000001">
        <property type="entry name" value="Serpin family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF161">
        <property type="entry name" value="SERPIN B13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="13"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027273669.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45095" checksum="31BDEA21F7A14064" modified="2023-06-28" version="1">MESLGTATAQFGFDLFKELDKTNDGNIFFSPVGISTAIGMIITGTGGATASELQKVLYSEKGTGSSRTKSEEKEVGKFFVLILKIEKTEVHDQFQKLLTEISKFPNGYELKISNRLFGEKTYLFLQKYIDYVEKYYHASLEPVDFVNAADESRKKINSWVESQTHEKVKDQFPEGSFSSSTKLVLINTVYFKGLWDRGFKKEHTKEEDFWLNKSTSKPVQMMTQCSSFSFTLLEDLQAKIVGIPYKNNDLSMFVLLPNDIDGLEKIIDRLSPEKLVEWTSPGHLEQREVDLHLPRMQVEESYELEATLEAMGLRSAFREHADYSGMSAHSGLQAQKFLHRSFVVVTEEGVEATAGTGMGFMVSSAAGCELMHCNHPFLFFIRHRESDSILFFGRFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G1X6</accession>
    <name>A0A9J7G1X6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein lin-52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lin52</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007643877.1">
        <property type="nucleotide sequence ID" value="XM_007645687.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274307.1">
        <property type="nucleotide sequence ID" value="XM_027418506.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G1X6"/>
    <dbReference type="GeneID" id="100755280"/>
    <dbReference type="CTD" id="91750"/>
    <dbReference type="OrthoDB" id="5834362at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070176">
        <property type="term" value="C:DRM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018737">
        <property type="entry name" value="DREAM_LIN52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489">
        <property type="entry name" value="LIN52 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489:SF2">
        <property type="entry name" value="PROTEIN LIN-52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10044">
        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027274307.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13930" checksum="67A105B7680189DD" modified="2023-06-28" version="1">MGWKMASPTDGTDLEASLLSFEKLDRASPDLWPEQLPGVAEFAASFKSPITSSPPKWMAEIERDDIDMLKELGSLTTANLMEKVRGLQNLAYQLGLDECLQLLGRDFSRESDFSKETDQPKDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G327</accession>
    <name>A0A9J7G327_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Liprin-alpha-4 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ppfia4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027273361.1">
        <property type="nucleotide sequence ID" value="XM_027417560.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G327"/>
    <dbReference type="GeneID" id="100760564"/>
    <dbReference type="KEGG" id="cge:100760564"/>
    <dbReference type="CTD" id="8497"/>
    <dbReference type="OrthoDB" id="2132119at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09568">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000003">
        <property type="entry name" value="liprin-alpha-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000002">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000004">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037622">
        <property type="entry name" value="LIP-1_SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF5">
        <property type="entry name" value="LIPRIN-ALPHA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="831"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="944"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="641"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027273361.1"/>
        </source>
    </evidence>
    <sequence length="1177" mass="132931" checksum="1666EED0C4481B1D" modified="2023-06-28" version="1">MCEVMPTINEGDPLGPPHGADADANFEQLMVNMLDEREKLLESLRESQETLVATQSRLQDALHERDQLQRHLNSALPQEFATLTRELSMCREQLLEREEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRAALERVTTLEEQLAGAHQQVSALQQGAGVRDGVAEEEGTMELGPKRLWKDDTGRVEELQGLLEKQNYELSQARERLVTLSATVTELEEDLGTARRDLIKSEELSSKHQRDLREALAQKEDMEERITTLEKRYLAAQREATSIHDLNDKLENELANKESLHRQCEEKARHLQELLEVAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEEHLRQLEGQLEEKNQELARVRQREKMNEDHNKRLSDTVDRLLSESNERLQLHLKERMAALEEKGRLSEEIEKLRQEVDQLKGRGGPFVDGIHSRSHVGSASDVRFSLSTATHAPPGLHQRYTVLREDSAKDWKPSPLSGVLAATTTTAAFDSDPEISDVDEDEPGGLVGTQVDVISPGGHSDAQTLAMMLQEQLDAINQEIRMIQEEKESTELRAEEIETRVTSGSMEALNLTQLRKRGSIPTSLTALSLASASPPLSGRSTPKLTSRSAAQDLDRMGVMTLPSDLRKHRRKLLSPVSREENREDKATIKCETSPPSSPRTLRLEKLGHSALSQEEGKSALEGQDSNPSSSNSSQDSLHKGAKRKGIKSSIGRLFGKKEKGRLIQLSRDATGHVLLTDSELSLQEPMVPAKLGTQAEKDRRLKKKHQLLEDARRKGMPFAQWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNALHRLKLRLAIQEMVSLTSPSAPPTSRTSSGNVWVTHEEMETLATSTKTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELEKRREESQHEIKDVLVWTNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNTLALVLQIPTQNTQARQVMEREFNNLLALGTDRKLDDGEEKVFRRAPSWRKRFRPRDHHSGGMLGTSAETLPVGFRVSTLGPLQPPPAPPKKIMPEAHSHYLYGHMLSAFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G480</accession>
    <name>A0A9J7G480_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lck-interacting transmembrane adapter 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lime1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003503203.2">
        <property type="nucleotide sequence ID" value="XM_003503155.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275759.1">
        <property type="nucleotide sequence ID" value="XM_027419958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G480"/>
    <dbReference type="GeneID" id="100767764"/>
    <dbReference type="KEGG" id="cge:100767764"/>
    <dbReference type="CTD" id="54923"/>
    <dbReference type="OrthoDB" id="9939965at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019815">
        <property type="term" value="C:B cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026072">
        <property type="entry name" value="Lime1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47740:SF1">
        <property type="entry name" value="LCK-INTERACTING TRANSMEMBRANE ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47740">
        <property type="entry name" value="LCK-INTERACTING TRANSMEMBRANE ADAPTER 1, LIME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15332">
        <property type="entry name" value="LIME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027275759.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35098" checksum="B7476D980D2C1D1C" modified="2023-06-28" version="1">MKGLGVSGVLSQPGRKNPPSGQDLQIELQVCTGPSVSPQRSSLLSPGPLFCFYKMRPPVPSAPLALLFLGCFSLLLWLWALCTACHRKRAQRQQTGLQGSLIPVEMSLLRQTHLCSLSKSDTRLHELHQGTRCSIAPRPASMDFLHPHWLEASRGSTRSQVTPSAFSSRQLPRAPPAAPATASSTSPEATYSNVGLAAIPRASLAASPMVWAGTQLTISCAKLGPGAEYACIQKHKETEQGYQESQQKTKMIPAPQMDLLYSRVCKPKRRDPRPVTDEPDPQGGRAILALGSDVEYEAITLRGQDVNQDPLENVYESIREVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G598</accession>
    <name>A0A9J7G598_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Insulinoma-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Zinc finger protein IA-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC113836331</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the INSM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276679.1">
        <property type="nucleotide sequence ID" value="XM_027420878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113836331"/>
    <dbReference type="KEGG" id="cge:113836331"/>
    <dbReference type="OrthoDB" id="8953942at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001458">
        <property type="entry name" value="INSM transcriptional repressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002055">
        <property type="entry name" value="INSM transcriptional repressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000488">
        <property type="entry name" value="Insulinoma-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042972">
        <property type="entry name" value="INSM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065">
        <property type="entry name" value="INSULINOMA-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065:SF5">
        <property type="entry name" value="INSULINOMA-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027276679.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="49592" checksum="92395152E85D16D8" modified="2023-06-28" version="1">MDGPIWRLRAPRRRYTKPRHVRLPIEEQQTVKGGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLAGGGGGANGAGGSGTCGGDALLFAPAELKMGTAFSAGAEAARGPGPGPPLSPAAALRPPGKRPAPPATLAAEPPAKAAKAPSAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGATRPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPAPAATRAPEPEAATRAEARDTAGGGSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAAPPPPPPPAATASSPEDILAFYAGSDDKSPQEAVGDGEAAGVLGLSAAAECHLCPVCGXTFPSKGAQERHLCLLHAAQVFPCKYCPATFYSSPGLTRHINKCXPSENRQVILLQVPPPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G9D1</accession>
    <name>A0A9J7G9D1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22 23" type="primary">Hipk3</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_027278139.1">
        <property type="nucleotide sequence ID" value="XM_027422338.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278140.1">
        <property type="nucleotide sequence ID" value="XM_027422339.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027422340.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G9D1"/>
    <dbReference type="GeneID" id="100772418"/>
    <dbReference type="KEGG" id="cge:100772418"/>
    <dbReference type="CTD" id="10114"/>
    <dbReference type="OrthoDB" id="10030361at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000022">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF45">
        <property type="entry name" value="HOMEODOMAIN-INTERACTING PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21 22 23" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="21 22 23" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 21 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="197"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="827"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="910"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1016"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1049"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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    </evidence>
    <evidence type="ECO:0000256" key="17">
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027278139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027278140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027278141.1"/>
        </source>
    </evidence>
    <sequence length="1230" mass="135178" checksum="5A0A6EC08230F373" modified="2023-06-28" version="1">MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPQTYVNGRNFGNSHPSTKGSAFQTKIPFTKPRGHSFSLQAGAVVVRDTAGATKVIAAQAQQAGVEVPRTVVWQNRLHFLEGPQRCGLKRKSEELDNHSGAMQIVDELSILPAMLQTNMGNPVTVVTTTTGSKQNCTSGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFSSLDEIVHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPVETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHPSSCETNNHSKMSLLRPVASNSTAALTANLTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSSHYNSVMPQPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCVETQDNRHTSEAEARNCQEASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDTDDEETSPRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGRSSPSPCKRPNSMSDDEQESGCETVDGSPTSDSSGHDSPFAESSFVEDTHQNTELGTCAGTEAKPAVGTAVEPPVGIESGLNVDEHMANTDSTCQPLIKGQPAPGKLNHPSASGARQQKPTSAFQQQQQQQQQQQQQQQQQQHLNFSQVQHFGTGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G9F8</accession>
    <name>A0A9J7G9F8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Apoptosis inhibitor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Api5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Monomer. Interacts with FGF2 and ACIN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the API5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016818851.1">
        <property type="nucleotide sequence ID" value="XM_016963362.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016818854.1">
        <property type="nucleotide sequence ID" value="XM_016963365.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278207.1">
        <property type="nucleotide sequence ID" value="XM_027422406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G9F8"/>
    <dbReference type="GeneID" id="100758910"/>
    <dbReference type="KEGG" id="cge:100758910"/>
    <dbReference type="CTD" id="8539"/>
    <dbReference type="OrthoDB" id="19224at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000092">
        <property type="entry name" value="apoptosis inhibitor 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758:SF19">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027278207.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59047" checksum="AAFD0CD073557912" modified="2023-06-28" version="1">MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFSPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLSTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENASNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRANEDTSSGSPPKKSPGGPKRDARQIYNPPSGKYSSNLGNFNYEQRGAFRGSRGGRGWGTRGNRSRGRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GA59</accession>
    <name>A0A9J7GA59_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100759622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276922.1">
        <property type="nucleotide sequence ID" value="XM_027421121.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027294331.1">
        <property type="nucleotide sequence ID" value="XM_027438530.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GA59"/>
    <dbReference type="GeneID" id="100759622"/>
    <dbReference type="KEGG" id="cge:100759622"/>
    <dbReference type="OMA" id="GVICMVS"/>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276922.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34455" checksum="9A521291953FF0D9" modified="2023-06-28" version="1">MIHNNSVTEFILFGLTQDPEKQKAVFGVFLILYIMTLMGNFLIVMTIKISQTLGSPMYFFLFYLSFADACFSTTTAPRLIVDSLSQKKTITYNECMTQVFAAHFFGCMEIFVLILMAFDRYVAICRPLRYTTIMSQRVCGVLVILAWVGSCIHSSAQIFLALRLPFCGPNVIDHYFCDLQPLLKLACMDTYVINLLVVSNSGVICMVSFILLLISYIVILYSLRNHSAEGRRKALSTCTSHFIVVVIFFGPCIFIYTRPPTIFPIDKMVAVFYTIGTPLLNPLIYTLRNAEVKNAMKKLWCGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GF91</accession>
    <name>A0A9J7GF91_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Ift122</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts with IFT43:WDR35; the interaction connects the 2 IFT-A subcomplexes. Interacts with IFTAP; the interaction associates IFTAP with IFT-A complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007646127.1">
        <property type="nucleotide sequence ID" value="XM_007647937.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284984.1">
        <property type="nucleotide sequence ID" value="XM_027429183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GF91"/>
    <dbReference type="GeneID" id="100771127"/>
    <dbReference type="KEGG" id="cge:100771127"/>
    <dbReference type="CTD" id="55764"/>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000003">
        <property type="entry name" value="intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000005">
        <property type="entry name" value="Intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000326">
        <property type="entry name" value="Intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000573">
        <property type="entry name" value="Intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056838">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25144">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25143">
        <property type="entry name" value="Zn_ribbon_IFT122_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="17">
        <location>
            <begin position="2"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="16">
        <location>
            <begin position="356"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="19">
        <location>
            <begin position="617"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 zinc ribbon" evidence="18">
        <location>
            <begin position="1051"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027284984.1"/>
        </source>
    </evidence>
    <sequence length="1242" mass="141847" checksum="1F8B337FA10E25AE" modified="2023-06-28" version="1">MRAVLTWRDKVEQCIYDLAFKPDGTQLILAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSSDFGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMSNGVISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSRWENIWMSRENEDAEDVIVNRYFQEIPSILKSTVYNSQGSEAEEEEQEEEDDSPRDGNSEEHNDILAVADWGQKLSFYQLSGKQIGKDRPLNFDPCCISYFTKGEYILVGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCRVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKKIAIYKNRLAIQLPEKILIYELYSDDSADMHYRVKEKIVKKFECNLLVVCADHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFREAYQIACLGVTDTDWRELAMEALEGLEFETAKKAFTRVQDLRYLELISSIEERKKRGESNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNINEPKAAVEMYISAGEHTKAIEISGSHGWVDMLIDIARKLDKAEREPLLMCARYFKKLDSPGYAAETYLKVGDLKSLVQLYVDTKRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFNDAAYYYWMLSMQCLDMAQADPAQKDVMLDKFHHFQHLAELYHGYQTIHRYTEEPFSFDLPETLFNISKFLLHSLTKATPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLRGLQIPARIQKSIELGTLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYEVLHLVEFYLEEGITDEEAVALIDLEAPRHKRESKWQEVASNNSQMLKLDETMDSLGDDDPFTAKLSFEQGGSEFVPVVVNRSVLRSMSRRDVLIKRWPPPLQWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHACCPYCRRRIDDTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GFE8</accession>
    <name>A0A9J7GFE8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">Ncapd2</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22">17A/GY</strain>
            <tissue evidence="21 22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027284100.1">
        <property type="nucleotide sequence ID" value="XM_027428299.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284101.1">
        <property type="nucleotide sequence ID" value="XM_027428300.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100753087"/>
    <dbReference type="KEGG" id="cge:100753087"/>
    <dbReference type="CTD" id="9918"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000695">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 16" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="10 16" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="19">
        <location>
            <begin position="77"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="18">
        <location>
            <begin position="1060"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="942"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1294"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1331"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1359"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027284100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027284101.1"/>
        </source>
    </evidence>
    <sequence length="1391" mass="156029" checksum="42B523000BBF08DA" modified="2023-06-28" version="1">MSSQNFEFHLPLSPEELLKSGGVNQYVVQEVLPIKYLPSQLRAFQSAFRARGPLAMLEHFDTVYSILHHFRSIDPGLKEDTLEFLIKVVSCHSQELPSILDDTTLSVSDRSAHLNALKMNCYALIRLLESFENMTSRTSLINLEVGGKGKKAQAKAAHGFDWEEERQPVLQLLTQLLQLDIRHLWNHSVIEEEFVSLVTGCCYRLLENPTISHQKNRPTREAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPSVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDTAGTKGFSAFLTELAERIPAILMSSMCILLDHLDGENYMMRNAVLAAMAEVVLQVLKGDQLEETARETRDQFLDILQAHGHDVNSFVRSRVLQLFTRIVQQKVLPLTRFQAVMALAVGRLADKSVLVCKNAIQLLASFVANNPFSCKLSDTDLAGPLQKETQKLQEMRAAQRQTAAASAALDPEEEWEAMLPEVKSTLQQFLELPQEEGDQQIADTETVEEVKGRIRQLLAKASYKQAIILTREATGHFQESEPFSHTDLEETSFLNLLGIIFKGPAASTQESHGDTVPAPTDSKDTPSVSEPEVPQRGDELVKQEMLVQYLQDACSFSQKITEAISIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLSPKGDSARATAQALVQNLSLLLVDASVGTIQCLEEILCEFVQKDEIKPAVTQLLWERTTEKVPCSPLERCSSVMLLGMMARGKPEIIGSNLDTLVRVGLDEKFPQDYRLAQQVCLAISNISDRRKPSLGEREPPFRLPQEHVLFERLREMVTKGFAHPHPLWIPFKEVAVSLTYQLAEGPEVICAQMLQGCAKQALEKLEKTTTEEDPKETVPTLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHRTKEPKEKNTSSETTMEEEMGLVGATADDTEAELIHSICEKELLDGNQVLAAFVPLLLKVCNNPGLYNDPALCAAASLALGKFCMISASFCDSQLRLLFTMLEKSSLPTVRSNLMIATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRRTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIGALAKNFFNELSHKGNAVYNLLPDIISRLSDPECGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCHRFRTARTERQYRDLAYCVSQLPLTDKGLHKMLDNFDCFGDKLLDESVFSAFLSVVGKLRRGAKPEGKATIDEFEQKLRACHTRGMDGIEELETGQEGSQQALSAKKPSAVSRRQPLTSIDSDNDFVTPKPRRTNRHRPNTQQRKSKKKAKVVFSSDESSEDELSAEMTEEETPKRTTPIRRSSARRHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJM2</accession>
    <name>A0A9J7GJM2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periphilin-1 isoform X5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100769134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027288618.2">
        <property type="nucleotide sequence ID" value="XM_027432817.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJM2"/>
    <dbReference type="GeneID" id="100769134"/>
    <dbReference type="KEGG" id="cge:100769134"/>
    <dbReference type="OrthoDB" id="8933311at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097355">
        <property type="term" value="P:protein localization to heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22896">
        <property type="entry name" value="periphilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057603">
        <property type="entry name" value="Periphilin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028851">
        <property type="entry name" value="Pphln1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836">
        <property type="entry name" value="PERIPHILIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836:SF4">
        <property type="entry name" value="PERIPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25234">
        <property type="entry name" value="Periphilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Periphilin-1 C-terminal" evidence="2">
        <location>
            <begin position="324"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027288618.2"/>
        </source>
    </evidence>
    <sequence length="414" mass="47898" checksum="DC481146F9AAFD85" modified="2023-06-28" version="1">MRPPMRDMRSPVRDMRPSVRDMRSPVRDKRPPVRDKRQPVRDMRPSVRDMRSPVHDMRSPELDKRPPVQDKRWPVRDMRAPELDKTAPLRDKRPPVRDKSPPVLDMRPPKLARHDEEGYSRVDYGECDKGHRFSHDPRRGSPHKGDDSGYRRSRGHHFTRQKSEYRNMRDAFRRKSFYSSQYSRDRSPHKRDAPFFRESPVGQKDAPHRRSGSSLSSRSYSPEGSKTSSFHQSQYTSKEKSIQSSKTSGDTSPSRSSEVSSSKVLDQPSWLTEKELAEDASKWDKGKPEKADENTSIDSSEFETGSTGPVFIDQTEEPESNTTDGTELCKDSQLSSRSKAIASKTKEIQQAYRQDFETFGMVVKMLVDKEPSLEKSIQFALRQNLQEMGERCVEELKRFITEYDNSTQDSGDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GKK7</accession>
    <name>A0A9J7GKK7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Low-density lipoprotein receptor-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">Lrp6</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027285673.1">
        <property type="nucleotide sequence ID" value="XM_027429872.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100772150"/>
    <dbReference type="KEGG" id="cge:100772150"/>
    <dbReference type="CTD" id="4040"/>
    <dbReference type="OrthoDB" id="72419at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019534">
        <property type="term" value="F:toxin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046849">
        <property type="term" value="P:bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060444">
        <property type="term" value="P:branching involved in mammary gland duct morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042074">
        <property type="term" value="P:cell migration involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060856">
        <property type="term" value="P:establishment of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990963">
        <property type="term" value="P:establishment of blood-retinal barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001702">
        <property type="term" value="P:gastrulation with mouth forming second"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008078">
        <property type="term" value="P:mesodermal cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000381">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000017">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000016">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000074">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000075">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017049">
        <property type="entry name" value="LRP5/6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF40">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036314">
        <property type="entry name" value="LDL_recpt-rel_p5/6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 25" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="20 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="23 31" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21 25 31" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 25" id="KW-0732">Signal</keyword>
    <keyword evidence="12 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11 25" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039967343" description="Low-density lipoprotein receptor-related protein" evidence="25">
        <location>
            <begin position="20"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1374"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="415"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="458"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="502"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="591"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="674"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="717"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="760"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="843"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="892"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="1026"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="1069"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="27">
        <location>
            <begin position="1114"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1206"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1556"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="1602"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1270"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1288"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1295"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1307"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1326"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1333"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1345"/>
            <end position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00057392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRNR" id="PIRNR036314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027285673.1"/>
        </source>
    </evidence>
    <sequence length="1613" mass="180319" checksum="297443679E8B547C" modified="2023-06-28" version="1">MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFGHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSNRFVIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWAARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSADREVIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDITLPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSIGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSKLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLHEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNCPVCLESQFQCASGQCIDGALRCNGDANCQDKSDENNCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTIYFICQRMLCPRMKGDGEAMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GPU2</accession>
    <name>A0A9J7GPU2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protocadherin gamma-B6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC118238284</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035295393.1">
        <property type="nucleotide sequence ID" value="XM_035439502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GPU2"/>
    <dbReference type="GeneID" id="118238284"/>
    <dbReference type="KEGG" id="cge:118238284"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
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    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF66">
        <property type="entry name" value="PROTOCADHERIN GAMMA-B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039903713" evidence="14">
        <location>
            <begin position="32"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="76"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="135"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="244"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="349"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="454"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="579"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035295393.1"/>
        </source>
    </evidence>
    <sequence length="850" mass="93173" checksum="D11AFCC5EBD133A3" modified="2023-06-28" version="1">MGGSCAQRQRPGRRPQVLFTLLLPLFCPALGQPVRYSIPEELDRGSVVGNLAKDLGLGVLEVSARKLRVSAEKLHFSVDSESGDLLVKDRIDREQICKGRRRCELELEAVLENPLNIFHVVVEIEDINDHAPQFEKRETRLEILESVSVGTRIPLEPATDPDINSNSIKDYQISSTPYFSLMVRVNPDGSKTPELSLEKLLDREEKRSHRLILTALDGGDPPRSATTQIEISVKDINDNSPVFSKEEYRISVSENLSPGSPVLQVTATDEDEGVNAEISYYFRSTAQSTRHVFSLDEKTGTVRNNQPLDFEEVESYTMEVEAKDGGGLSTQCKIIIEVQDENDNSPEILITSLSERILENSPPGVVVAIFKTRDPDFGGNGEVRCDISKGLPFKIHASSSNYYKLVTDGAIDREQNPQYNVTITATDRGKPPLSSSTTVTLHITDVNDNAPAFQKSSYIVHVSENNPPGASIAQVSASDPDLGSNGHISYSIIASDLEPQSLWSYVTVNAQSGVVFAQRAFDHEQLRSFQLTLQARDQGSPPLSANVSLRVLVGDCNDNAPRVLYPALEPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASDPGLFSLGLRTGEVRTARALGDKDAARQRLLVGVRDGGQPPLSATATLLLVFADSLQEALPDLSDRPLPPDPQAELQFYLVVALALISVLFLLAVILAIALRLRHSSSSSVWGCFQPGFCSKTRPGVSLNYSEGTLPYSYNLCIGQTGKTELNFLKCSAPLPSAEDIVCSGSPGASIPLHIGDDLITHPETLISVSFVLFFNNPSFLYIRHSNFVFLSRFIFENRFNCLLNDEMTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GR08</accession>
    <name>A0A9J7GR08_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Zinc finger CCCH domain-containing protein 13 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC100756984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3 4 5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4 5">17A/GY</strain>
            <tissue evidence="3 4 5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027289409.1">
        <property type="nucleotide sequence ID" value="XM_027433608.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289410.1">
        <property type="nucleotide sequence ID" value="XM_027433609.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305790.1">
        <property type="nucleotide sequence ID" value="XM_035449899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GR08"/>
    <dbReference type="GeneID" id="100756984"/>
    <dbReference type="KEGG" id="cge:100756984"/>
    <dbReference type="OrthoDB" id="9634854at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052690">
        <property type="entry name" value="Antho-RFamide"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31709">
        <property type="entry name" value="LEUCINE ZIPPER PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31709:SF3">
        <property type="entry name" value="LEUCINE ZIPPER PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027289409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027289410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035305790.1"/>
        </source>
    </evidence>
    <sequence length="949" mass="113867" checksum="A41E310351E9B1D7" modified="2023-06-28" version="1">MAWNPRRGRGSGNVTGNREDEIRFRRQLEALSSDEEYSEQDDTQRPSFRGPVAIRRHHRGIGFRSGGRGRNDNFFRRRFPENHPSFLLMRHDNSEDRSGWNGNQSEERQPQIEGNQVSFRRFHDHSQSRGRPINRSHGRHSRSPSPFRRAPVHSDRPYHDHSDRPHLDHFDRPQDDHLDRPRHDHSGRPHDHSDRPRHDYSVRLYHDHSDRLHLDHLDRPQDDHLDRPRHDHVGRPHHDHADRLRHDHLDRPQDEHLDGPRHDHANRPYYDHSDRPRHDHGARPYHDHTDRPRHDHSDRFHLDHLDRPQDDHLDRPRHDHVGRPHHDHLDRPEDELSDGPRHDHANRPYYDHSDRPRRDHLDTPEDELSDEPRHDHANRPYYDHSDRPRHDHLDRPEDELSDEPRHDHANRPYYDHSDRPRHAYLDRPEDEHSDGSHHDHANRPYYDHSDRSEDELSDESRHDHANRPYYDHSDRPRHDHLDTPEDELSDEPHHDHANRPYYDHADRPRHDQAIRPYHDHSGRPRHDHLDRPEDELSDRPRHDHANRPYYDHSDRPRHDHLDRPEDELSDEPHHDHANRPYYDHSDRPRHDQASRPYHDHSDRPRHDQAGRPYHDHSDRPHLDRLDRLQNDHSDRPRHDHAGRPHHEYSDRPYHDHSDRPHLDHSGRFHHDHAGRPHHDHSDRPYHDNLDRPHHDHSDRPRLGHMGRARLSRAGLARRGQRGRDHLNHTGLALPNHAERAHLSHTELAHSGHRGRARRGQRGRARPNRTGLVRNSHAGRANNDHLGRLHRGRVRRAHNNRTWRSRSLEERYRGQRERFGRIQTSPESDPEIDRTSTIREQTEYLFDQERHRNELINLNGGLIEEGYSSDQSDESSDSLWRPEVDAEFLNGRYTTIKTIPRHPKGVRLSFNIGARNNRTNLSLHTRFTILRTLRRARLNNMNNGQGRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GSS9</accession>
    <name>A0A9J7GSS9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylacetamide deacetylase-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118238445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035297075.1">
        <property type="nucleotide sequence ID" value="XM_035441184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GSS9"/>
    <dbReference type="GeneID" id="118238445"/>
    <dbReference type="KEGG" id="cge:118238445"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF32">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="194"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035297075.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33215" checksum="0029E311A02E393C" modified="2023-06-28" version="1">MQGVLVYRKHSVGDDGPSWPPSSSRALRSMKEKYRKLPGYHHPVLINDCQNASIYFLKNLASFGVDPSRVVLCGDSVGAWAVAIVTQALTRIPSLSQIKAQILICPLVNLINFQLPSHQQNKNVPLLTRDFMFMCFFKYLVIDPSWKDAILTGSAIPLDKWKKYRKWLSYDNIPRRFWSQDPQPEILGPFNEAAYLETKHTWNAELSPLLADDKTIAQLPETFLVSCEHDIFRDDALLYKKRLEDQGVPVSWYHVEDGFHGCLLLFDKKCFSFPCCMKLINAVISYIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GTT6</accession>
    <name>A0A9J7GTT6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA-binding protein with multiple splicing 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rbpms2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035299242.1">
        <property type="nucleotide sequence ID" value="XM_035443351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GTT6"/>
    <dbReference type="GeneID" id="100752492"/>
    <dbReference type="KEGG" id="cge:100752492"/>
    <dbReference type="CTD" id="348093"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12683">
        <property type="entry name" value="RRM_RBPMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000037">
        <property type="entry name" value="RNA-binding protein with multiple splicing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034787">
        <property type="entry name" value="RBPMS2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035299242.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="22508" checksum="DA552E1E02528934" modified="2023-06-28" version="1">MSNVKPDVEHCTGAGTGTGPSGPLEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTSRQPVGFVIFDSRAGAEAAKNALNGIRFDPDNPQTLRLEFAKANTKMAKSKLIATPNPTNVHPALGAHLIARDPYDLMGAALIPASPEAWAPYPLYTTELAPAISHTALTYPAATAAAAATLHAQVRWYPSSDTTQQGWKYRQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GV05</accession>
    <name>A0A9J7GV05_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Synaptic vesicular amine transporter isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Slc18a2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:73740"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:73744"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297632.1">
        <property type="nucleotide sequence ID" value="XM_035441741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GV05"/>
    <dbReference type="GeneID" id="100774860"/>
    <dbReference type="KEGG" id="cge:100774860"/>
    <dbReference type="CTD" id="6571"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000083">
        <property type="entry name" value="synaptic vesicular amine transporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000116">
        <property type="entry name" value="synaptic vesicular amine transporter isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF30">
        <property type="entry name" value="SYNAPTIC VESICULAR AMINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="22"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035297632.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="56406" checksum="C845125DC6B85F3C" modified="2023-06-28" version="1">MALGELALLRWLRDTRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIEHEKNTTEIQTTKAALTASTSGSFQGIFSYYDNATIPITGNVTRNASRGFPGEQPYKATTQHIVTNTSTVPSDCPSKDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTILLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGIAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIVDIVFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNVQSYPIGDDEESESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GXN6</accession>
    <name>A0A9J7GXN6_CRIGR</name>
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        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 62 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ccdc62</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035299212.1">
        <property type="nucleotide sequence ID" value="XM_035443321.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="100766639"/>
    <dbReference type="KEGG" id="cge:100766639"/>
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    <dbReference type="OrthoDB" id="6155277at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="198"/>
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    </feature>
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        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035299212.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="81505" checksum="9729D9A468AFF4E7" modified="2023-06-28" version="1">MRGRKGASSRAAGSPAPLRLGAYGVSEVTRCWHSLSVGARASPMNPSANFFLRRQNIGSEFENSTIEKQRKELQLLIGELKDRDKELNDMVAVHQRQLLSWEEDRQKVLTLEERCSKLEGELHKRTDIIKSLMKKVKILESNQAECQTALQKTQQQLQEMVQKATHSVLLSEDLEARNENLSSTLVELSAQVGQLQAREQSLTTMIKLKDKDIIEAVNHISDCSAKFKLLEHALRDAKMAETCIVKEKQDYKQKLKALRIEINKLKEDLNEKTTENNEQREEIIRLKQEKSCLNDELIFTAEREKRKDELLDIAKSKQDRTNSELQNLRQIYVKQQSDLQFLNFNVENTQELIQIYDSKMEESKSLEYSRDMCLSDLDNNYPKIDIKRERNQKSLVKDQKFEVTLTQHNRSDKSSCDACREKKLQVNTTFGEKSVIALSSLFTKDLLEKQKSWSLGGKIQTEPENKITLCKIHAKSPKSNEVELQMEEKELSETSISLSDEKQWHDINVYLGLSNCSASKQQGKPDEDCQDPTATSEISCCTQNEVYMGDIDLCNSKCCHPSNIIVEAPGYMTDIEWMNIFKPSKTQRIVRHKTLCTCSGGVSGTKYNSSASEFVAVQPPQCLGPSKSAEREDESETSPDKITSFKSLFISKEAASSNEKDDFSPTSKLQRLLAESRQMVTDLELSTLMPISCENLNRSKLEVSEEPDDKNTLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GXV7</accession>
    <name>A0A9J7GXV7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin regulator protein PCP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pcp4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PCP4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035299333.1">
        <property type="nucleotide sequence ID" value="XM_035443442.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311905.1">
        <property type="nucleotide sequence ID" value="XM_035456014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GXV7"/>
    <dbReference type="GeneID" id="100762325"/>
    <dbReference type="KEGG" id="cge:100762325"/>
    <dbReference type="CTD" id="5121"/>
    <dbReference type="OrthoDB" id="9944346at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052142">
        <property type="entry name" value="Calmodulin_Regulator_PCP4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15359:SF7">
        <property type="entry name" value="CALMODULIN REGULATOR PROTEIN PCP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15359">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035299333.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7973" checksum="D4B20312FAC2C3C2" modified="2023-06-28" version="1">MHNAAEVTVNFTLNRQGAGATNGKDKTSGDNDGQKKVQEEFDIDMDAPETERAAVAIQSQFRKFQKKKAGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZ38</accession>
    <name>A0A9J7GZ38_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Gpn3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer with GPN1. Binds to RNA polymerase II (RNAPII). Interacts directly with subunits RPB4 and RPB7 and the CTD of RPB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035299190.1">
        <property type="nucleotide sequence ID" value="XM_035443299.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302933.1">
        <property type="nucleotide sequence ID" value="XM_035447042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GZ38"/>
    <dbReference type="GeneID" id="100764448"/>
    <dbReference type="CTD" id="51184"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035299190.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43999" checksum="6B9DCE1B765CB2E2" modified="2023-06-28" version="1">MPRYAQLVMGPAGSGKSTYCSTMVQHCEALNRSVQVVNLDPAAEHFNYPVMAGESCTASPGTESGLLSPEGVCSWEAARGGDISESDVVTPPTPLRRVLHLNLETSPSNLPSSTPQHWSYRHVCAQLFTWVLEFHTQVLMLVHQALFISGRLPSPTDIRELIEVDDVMEDSSLRFGPNGGLVFCMEYFANNFDWLENCLGHVEDDYILFDCPGQIELYTHLPVMKQLVQQLEQWEFRVCGVFLVDSQFMVESFKFISGILAALSAMISLEIPQVNIMTKMDLLSKKAKKEIEKFLDPDLYSLLEDSTGDLRSQKFKKLTKAVCGLIDDYSMVRFLPYDQSDEESMSIVLQHIDFAIQYGEDLEFKEPKEQEEESSSMFDEYFQERQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2L6</accession>
    <name>A0A9J7H2L6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC118239111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118239111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035302958.1">
        <property type="nucleotide sequence ID" value="XM_035447067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H2L6"/>
    <dbReference type="GeneID" id="118239111"/>
    <dbReference type="KEGG" id="cge:118239111"/>
    <dbReference type="OrthoDB" id="9633120at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035302958.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="29870" checksum="D1AB124811EDEFD4" modified="2023-06-28" version="1">MAVLLFPEGSVVRDRDSELSSTLKPKKALLAWLRSLGGGVSPNTSSLPQGSWGGSGLLSSSSDRSGSLGAERRWPSGSSGKRQLREPRPWGDPAQAAARMEETSSGAGATGDGLPPQLSSPTAWRGLLQGPTSRRGLCLGPGGGGSRGTRQAQRGKRAASWGRSQEHTAPRPLIVSPLPPGGKQEACRLAERRTGSRANERSRRRAWRQMSAGKRGGTSGRAVTLFPPFGLEAPPFVFPAQSIKIGKKKSPDRSGRVRRRFPHPLPPPPPSLLTMCKAAGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2U4</accession>
    <name>A0A9J7H2U4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100758000</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cell membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301944.1">
        <property type="nucleotide sequence ID" value="XM_035446053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H2U4"/>
    <dbReference type="GeneID" id="100758000"/>
    <dbReference type="KEGG" id="cge:100758000"/>
    <dbReference type="OrthoDB" id="9008036at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15418">
        <property type="entry name" value="7tmA_OR9G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035301944.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35173" checksum="3299C69DFE79A90F" modified="2023-06-28" version="1">MEVDNRTILTEFILLGFTEDPHWQMILFVIFLSIYFMTLSGNMTLIILIRIDSRLHTPMYFFIGGLSFLDFWYNSVYIPKILVNCISEDKSISLAGCGAQFFFSCVAAYTECYLLASMAYDRHAAICSPLLYSSIMSTSLCTGLVAGSYVGGFLNAIAHTANTFRLSFCGKNIIDHFFCDVLPLVKMSCTDTRVYVKILSSMVGFTVLSSILAILISYCNILLAILRIHSASGRRKAFSTCASHLVSVTLFYGSLLFMYSRPSSNYSLQRDKVAAMFYNIINPLLNPFIYSLRNKDVKEAFKKLIQNIQQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H9U7</accession>
    <name>A0A9J7H9U7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Melanocyte protein PMEL isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Pmel</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEL/NMB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306515.1">
        <property type="nucleotide sequence ID" value="XM_035450624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H9U7"/>
    <dbReference type="GeneID" id="100769117"/>
    <dbReference type="CTD" id="6490"/>
    <dbReference type="OrthoDB" id="9939762at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045219">
        <property type="entry name" value="PKAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046846">
        <property type="entry name" value="PKAT_KLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059017">
        <property type="entry name" value="PMEL_NMB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11861:SF1">
        <property type="entry name" value="MELANOCYTE PROTEIN PMEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11861">
        <property type="entry name" value="MELANOCYTE PROTEIN PMEL 17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20433">
        <property type="entry name" value="PKAT_KLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26141">
        <property type="entry name" value="PMEL_NMB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="359"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035306515.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="79849" checksum="364A1503635C0ABD" modified="2023-06-28" version="1">MLGPMFSLSVALHPTKINTLHFEYHNEMKWDIALSSEKGLRTLGSYGTFLLGSRNQDWLGVPRQLGTKAWDRQLYPEWTEVQAPDCWRGGPVSLKVRNDGPTLIGANASFSITLHFPESQKVLPDGQVIWTNNTIVNGSQVWGGQPVYPQGPDDACIFPDGGPCPSGPRPPRRSFVYVWKTWGQYWQVLGGPVSRLSIATGHSWVGTHTMEVTVYHRRGPQSYVPLAHSSSTFTITGKSLERNKASQADGMRWEGCLGLERGSQCQPSKGRGRKIWAEKCETNSHLASQLVCEEHGCGRGVTQAWFLILLAPTPDQVPFSVSVSQLQALDGENKRFLRNQPLIFALHLHDPSGYLVEADLSYTWNFGDNTGTLISRAVEVTHTYLESGSVTAQVVLQAAIPLSSCGSSPVPGTTDGYMPTAEASGTTSILGTTTEGVGTTTGQMPTTQPSGTTVVQMPTTEGIATTSKQLPTSAVLDTTLAEMSTADGRGTTPTRPAGVTDAQAMTTELVETTTEALPTPEPEGPDASPFLPTESSTGSVTPLLDGIDTLMLVKRQVPLDCVLYRYGSFSLTLDIVQGIENAEILQAVTSSKGDAFELTVSCQGGLPKEACMDISSPGCQPPAQRLCQPVPPSPDCQLVLHQALKGGSGTYCLNVSLADANSLAVASTQIVVPGQEGGLGQAPLLVGVLLVLMAVVLASLMYRRRLGKQGPVSQTPNGSTHWLRLPSVFRTCHTGENSPLLSGQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HAB8</accession>
    <name>A0A9J7HAB8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100762763</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the presentation of foreign antigens to the immune system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306826.1">
        <property type="nucleotide sequence ID" value="XM_035450935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HAB8"/>
    <dbReference type="GeneID" id="100762763"/>
    <dbReference type="KEGG" id="cge:100762763"/>
    <dbReference type="OrthoDB" id="8936120at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002486">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002476">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07698">
        <property type="entry name" value="IgC1_MHC_I_alpha3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000014">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF251">
        <property type="entry name" value="HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039939632" evidence="12">
        <location>
            <begin position="24"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="209"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035306826.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41475" checksum="F251462D7CB71C37" modified="2023-06-28" version="1">MGRWRRALLLLLAAALAPSQTRAGSHSLRYFSTFVSRPGLGEPRYMEVGYVDDTQFVRFDSDAENPRMEPRAPWMEREGPEYWERETWRAKDWEQDFRLYLRTALGYYNQSEGGSHTYQVCVCGCDMGSDGRLLHGYEKHAYEGRDYLVLNEDLRTWTVADPAVQITQHMLQQDGYEERYRAYLEDECLKSLRRYLENGKDQLLRTDPPKAHVTHHPGPKGDVTLRCWAMGFYPAEITLTWQREEEEQTQDMELVETRPSGDGTFQKWAAVVVPSGEEQKYTCHVYPEGLPEPLTLRWEPPPQSTVPIMAVIAVLVLLVTIITAVVAVSRKKRRNTGVQDEDSKTHKNELILMLAAGDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCR2</accession>
    <name>A0A9J7HCR2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Refilin-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC113830747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with FLNA and FLNB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Refilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307093.1">
        <property type="nucleotide sequence ID" value="XM_035451202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCR2"/>
    <dbReference type="GeneID" id="113830747"/>
    <dbReference type="KEGG" id="cge:113830747"/>
    <dbReference type="OrthoDB" id="9932345at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031005">
        <property type="term" value="F:filamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061572">
        <property type="term" value="P:actin filament bundle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900158">
        <property type="term" value="P:negative regulation of bone mineralization involved in bone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061182">
        <property type="term" value="P:negative regulation of chondrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028215">
        <property type="entry name" value="Refilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31848">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31848:SF2">
        <property type="entry name" value="REFILIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15068">
        <property type="entry name" value="FAM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035307093.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23304" checksum="9CF5C62EA74B031E" modified="2023-06-28" version="1">MVGRLSLQDVPELVDTKKKGDGVLDSPDSGLPPSPSPSHWGLAAAAGGGGERVPVPGALEPDAAATPAIPNPASLTQSLAAVCSPRLCPLSFGEGVEFDPLPPKEIKYTSSVKYDSERHFIDDVQMPLGLAVASCSQTVTCIPNCTWRNYKAEVHFQPRHKAARFLSTTIIYPKYPKTIYTTTLDYNCHKKLRRFLSSVELEATEFLGSDGLSDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HF10</accession>
    <name>A0A9J7HF10_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRAME family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100751333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRAME family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035293755.1">
        <property type="nucleotide sequence ID" value="XM_035437864.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309721.1">
        <property type="nucleotide sequence ID" value="XM_035453830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HF10"/>
    <dbReference type="GeneID" id="100751333"/>
    <dbReference type="KEGG" id="cge:100751333"/>
    <dbReference type="OrthoDB" id="9628575at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026271">
        <property type="entry name" value="PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF3">
        <property type="entry name" value="PRAME LIKE 17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038286">
        <property type="entry name" value="PRAME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035309721.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="54178" checksum="D57225604AD3C7E6" modified="2023-06-28" version="1">MSIYNPPSLQHLAMQNLLWNEASTISTLEYLPPHLFPPVFKEAFTGRHMQLLKAMVAAWPFSYLPVGALMETPNVELLQAVLGGVDILQAQKVRPRWKLRVLDLRNVNQDFLNVWASRKSWYYCSTEHESEKKDNEMRPDVKVVTDLSLRCHLKEHQTCLLQWAQQRKDSVQLSCVKMEICDFPAEIIKEFLDIFPPEELHLTTNSVLPLLHHIASHLGHMTKLRKCHLSHIFVHGYCDVNAWSVTEDVCAIQFLSQLFKLTSVEHFSMDTFYFFSDVMQLLFSSLKTPLESLSITDSLGPVNLNLLSQCQGLCQLRHLSLSNSMFSLSGDIHLRVLLENTAHTLQTLELVNCRMRDSELRVLLPALSQCSQLITVNFYDNNFSIAALKKLVQGMACLSNLTGEFYPAPLECYDPLGYVLVEEFAQVCLELQDIFFAKRQPKKIAFATRICPKCRRRCVYNMETRLCQCWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J5X0</accession>
    <name>A0A9J7J5X0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vascular permeability factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Vegfa</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027243191.1">
        <property type="nucleotide sequence ID" value="XM_027387390.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100755957"/>
    <dbReference type="KEGG" id="cge:100755957"/>
    <dbReference type="CTD" id="7422"/>
    <dbReference type="OrthoDB" id="6370328at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005172">
        <property type="term" value="F:vascular endothelial growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050930">
        <property type="term" value="P:induction of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001938">
        <property type="term" value="P:positive regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060754">
        <property type="term" value="P:positive regulation of mast cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038084">
        <property type="term" value="P:vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.160.10:FF:000001">
        <property type="entry name" value="Vascular endothelial growth factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.160.10">
        <property type="entry name" value="Vascular endothelial growth factor, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050507">
        <property type="entry name" value="PDGF/VEGF_growth_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027928">
        <property type="entry name" value="VEGF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036841">
        <property type="entry name" value="VEGF_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12025">
        <property type="entry name" value="VASCULAR ENDOTHELIAL GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12025:SF5">
        <property type="entry name" value="VASCULAR ENDOTHELIAL GROWTH FACTOR A, LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14554">
        <property type="entry name" value="VEGF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57593">
        <property type="entry name" value="Heparin-binding domain from vascular endothelial growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0497">Mitogen</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="14">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027243191.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15892" checksum="8AD8FE6FBE54ECB8" modified="2023-06-28" version="1">MSGALGCPIGVWLAGSLTSVIXFLPLQIMRIKPHQSQHIGEMSFLQHSRCECRPKKDRTKPEKKSVRGKGKGQKRKRKKSRFKSWSVHCEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J777</accession>
    <name>A0A9J7J777_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribitol-5-phosphate xylosyltransferase 1 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Rxylt1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027248091.1">
        <property type="nucleotide sequence ID" value="XM_027392290.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J777"/>
    <dbReference type="GeneID" id="100757873"/>
    <dbReference type="KEGG" id="cge:100757873"/>
    <dbReference type="CTD" id="10329"/>
    <dbReference type="OrthoDB" id="8560686at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120053">
        <property type="term" value="F:ribitol beta-1,4-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21099">
        <property type="entry name" value="RXYLT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055286">
        <property type="entry name" value="RXYLT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057538">
        <property type="entry name" value="RXYLT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057539">
        <property type="entry name" value="RXYLT1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15576">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15576:SF1">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24785">
        <property type="entry name" value="RXYLT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24786">
        <property type="entry name" value="RXYLT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RXYLT1 N-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RXYLT1 C-terminal" evidence="1">
        <location>
            <begin position="274"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027248091.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53670" checksum="EF26ECCA3A7565B7" modified="2023-06-28" version="1">MRLTRTRLCSLLVALYCLFSIYAAYHVFFGRRRRATAASSRGSRKAAVQAKERRGRGRAEAGWAAGLRLALRLALGSLGPLDQSALESEEWNPWEGDEKSEQQHRIKTSLQMLTKSTREKTERSIQIWGKAAIGLYLWEHIFEGTLDPTDVTAQWREGQSIVGRTHYSFITGPAVLPGYFSIDVDNVVLVLNGREKAKIVHATQWLLYTQNLIQTQKLQHLAVVLLGNEHCDNDWIMKFLKRNRGFVDLLFITYDSPWINGADVLQWPLGVATYRKFPVVEATWSMLHDERPYICNFLGTVYENSSRQALMNILKQNGSEKLCWVSAREQWQPQETNESLRNYQDALLQSDLTLCPVGVNTECYRIYEASSFGSVPVVEDVMTAGHCGNTSSHHSTPLQLLKAMGAPFIFIKDWKELPAILEKEKTIILQEKVQRRKMLLQWYQHFKTELKRKFTNTLESSFFMNNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J7U8</accession>
    <name>A0A9J7J7U8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein FAM155A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Fam155a</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NALF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027243687.1">
        <property type="nucleotide sequence ID" value="XM_027387886.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J7U8"/>
    <dbReference type="GeneID" id="100754176"/>
    <dbReference type="KEGG" id="cge:100754176"/>
    <dbReference type="CTD" id="728215"/>
    <dbReference type="OrthoDB" id="10047996at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015275">
        <property type="term" value="F:stretch-activated, monoatomic cation-selective, calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055288">
        <property type="entry name" value="NALCN_aux_factor_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819:SF9">
        <property type="entry name" value="NALCN CHANNEL AUXILIARY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN FAM155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027243687.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52400" checksum="E40550D33E4A6F04" modified="2023-06-28" version="1">MTRGAWMCRQYDDGLKIWLAAPRENEKPFIDSERAQKWRLSLASLLFFTVLLSDHLWFCAEAKLTRTRDKEHHQQQQQQQQQQQQQQQQQQQRQQQRQRQQQRQRQQEPSWPALLASMGESSPAAQAHRLLSASSSPTLPPSPGGGGGGSKGNRGKNNRSRALFLGNSAKPVWRLETCYPQGASSGQCFTVESADSVCARNWSRGAAAGEEQSSRGSRPTPLWNLSDFYLSFCNSYTLWELFSGLSSPSTLNCSLDVVLTEGGEMTTCRQCVEAYQDYDHHAQEKYEEFESVLHKYLQSDEYSVKSCPEDCKIVYKAWLCSQYFEVTQFNCRKTIPCKQYCLEVQTRCPFILPDNDEVIYGGLSSFICTGLYETFLTNDEPECCDIRSEEQSAPRPKGTLDRKDSCPRTSLTVSSATRLCPARLKLCVLVLILLHTVLTASAAQNSTGLGLGGLPTLEDNSTRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JE76</accession>
    <name>A0A9J7JE76_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Acid sphingomyelinase-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">Smpdl3b</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="24">Binds 2 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with TLR4, TLR7, TLR8 and TLR9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255330.1">
        <property type="nucleotide sequence ID" value="XM_027399529.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100772622"/>
    <dbReference type="KEGG" id="cge:100772622"/>
    <dbReference type="CTD" id="27293"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000057">
        <property type="entry name" value="Acid sphingomyelinase-like phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017064">
        <property type="entry name" value="ASM-like_Pdiesterase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF25">
        <property type="entry name" value="ACID SPHINGOMYELINASE-LIKE PHOSPHODIESTERASE 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036767">
        <property type="entry name" value="ASM-like_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="18" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 23" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="11 23 24" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039967225" description="Acid sphingomyelinase-like phosphodiesterase" evidence="23">
        <location>
            <begin position="23"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="25">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="26">
        <location>
            <begin position="295"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00063194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR036767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR036767-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027255330.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51586" checksum="6FE5A768C279D798" modified="2023-06-28" version="1">MTLKMTMLRWLILLAPWGVAGAELGRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVPNAGPWGDYLCDSPWALVNSSIYAMKEIEPKPDFIFWTGDDTPHIPNEKLGEAAVLAIVERLTNLIREVFPDTKVYAALNHXFHPKNQFPERARHLXQVADWRPWLATGAIPGCDILGAFYSEKLPGNSSTGRVVVLNTNLYYSSNEQTAGMADPGQQFQWLEDVLSNASRDGEMVYIIGHVPPGFFEKTQDKAWFRESFNEEYLKVVQRHHRVIAGQFFGHHHTDSFRMFYDNTGAPISVMFLVPGVTPWKTTLPGVVNGANNPGIRVFEYDRVTLNLQDMVTYFLNLSQANAQGTPHWELEYRLTEAYQVQDAGTSSMHKALTRIASDQHTLQRYYVYNSVSYDHSACGDICRTEHVCAMQQVAFRPYATCLHGLGSRLLPGFLLMLTVLPSLTVLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JK44</accession>
    <name>A0A9J7JK44_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibulin-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Developmental arteries and neural crest EGF-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Fbln5</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. Monomer, homodimerizes in presence of Ca(2+). Interacts with ELN. Interacts (via N-terminus) with the integrins ITGAV/ITGB3, ITGAV/ITGB5 and ITGA9/ITGB1. Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1. Interacts with EFEMP2 with moderate affinity. Interacts with LOXL1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027274935.1">
        <property type="nucleotide sequence ID" value="XM_027419134.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JK44"/>
    <dbReference type="GeneID" id="100759853"/>
    <dbReference type="KEGG" id="cge:100759853"/>
    <dbReference type="CTD" id="10516"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000091">
        <property type="entry name" value="Fibulin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000487">
        <property type="entry name" value="Fibulin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000190">
        <property type="entry name" value="fibulin-5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF107">
        <property type="entry name" value="FIBULIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039949126" description="Fibulin-5" evidence="17">
        <location>
            <begin position="37"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027274935.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51748" checksum="9EFAA6439BB8CDFE" modified="2023-06-28" version="1">MGPRSFEPMNSGHCRQRRMILTVAILALWLPHPGNAQQQCTNGFDLDRQTGRCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNSVYRGPYSNPYSTPYSGPYPAAAPPVPASNYPTISRPLVCRFGYQMDEGNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNDDGRSCQDVNECETENPCVQTCVNTYGSFICRCDPGYELEEDGIHCSDMDECSFSEFLCQHECVNQPGSYFCSCPPGYVLLDDNRSCQDINECEHRNHTCTPLQSCYNLQGGFKCIDPIRCEEPYLLIGDNRCMCPAENTGCRDQPFTILFRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JLA4</accession>
    <name>A0A9J7JLA4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113835374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269051.1">
        <property type="nucleotide sequence ID" value="XM_027413250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JLA4"/>
    <dbReference type="GeneID" id="113835374"/>
    <dbReference type="KEGG" id="cge:113835374"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027269051.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38237" checksum="DC33440C73BA86DB" modified="2023-06-28" version="1">MAENNYSVTNEFILVGFSDHPDLNTLLFLVFFVIYLVTMVGNLGLVVLIYMEHRLHTPMYIFLGNLALMDSCCSCAITPKMLQNFFSVDRRISLYECMVQFYLLCLAETADCFLLAAMAYDRYVAICNPLQYHTMMSKKLCLQMTVGAYIAGNLHSMIHIGFLFRLTFCRSHVIKHFFCDFLPLYRLSCVDPYLNELMILIFAGLIQVFTITVVLVSYLYVLFTIFTMKSKDGRGKTLSTCASHFLSVSIFYGSLLYMYVQPHSFNEGDKDIPVAIFYTVIIPLLNPFIYSLRNKEVINVMKRIMKRFFSNIRKQGPSPLEKRYKAENALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JM91</accession>
    <name>A0A9J7JM91_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100769618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative pheromone receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027265292.1">
        <property type="nucleotide sequence ID" value="XM_027409491.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JM91"/>
    <dbReference type="GeneID" id="100769618"/>
    <dbReference type="KEGG" id="cge:100769618"/>
    <dbReference type="OrthoDB" id="9626086at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016503">
        <property type="term" value="F:pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000033">
        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027265292.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34115" checksum="BEC1BF00F8249401" modified="2023-06-28" version="1">MKLEMVLSISEMTIFLLLTGLGTVANVSVFVNYICTFMGSGEKSIHLILIHLAFTNITMLFSKGVQTPITALGLRHFLGDVGCHIIVYLERVARGLSICTSSLLTVVQAIIMSPRTSWWGRLRLRSVECVLLSLLFFWILNSLISMNLLYSIRNRGTNILQQSKNNKYCYIKKESQKVNNMFLALMVLRDAVFQGAMGGASGYMVLLLHKHHQHVLYLQNSKLLYRTPPELRAAQSVLLLMLCFLFFYLADCAVSLYLSFSLKNDSLTMHLQQFLTLGYAILSPFILIHRDGHLAECWHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JTM5</accession>
    <name>A0A9J7JTM5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC113838851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027290159.1">
        <property type="nucleotide sequence ID" value="XM_027434358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JTM5"/>
    <dbReference type="GeneID" id="113838851"/>
    <dbReference type="KEGG" id="cge:113838851"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF23">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="12">
        <location>
            <begin position="275"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027290159.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52509" checksum="F2EBAE43E697684C" modified="2023-06-28" version="1">MNVTTLFSFTSPAVKRLLGWKQCDKEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPCSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDCCEFPFSSKQKEVCINPYHYKRVESPVLPPVLVPRYSEYNPQQKLLLAQFCNLGQNEPHMPPNATFPDSFRQPSTHPFPHSSISSSPNSPGSSSSSSSTYPHSRTSSGPGSPFQMPADIPTTAYQPSQDAMAQDGSQPMDTNMMAPALPSEINRGDVQAVVYEEPKHWCSIVYYELNNRVGDTFQASSTSVLVDGYTDPSNNKNGFCLGLLSNINRNSTIENTRQHIGKGVHLYYVGGEVYVECLSDKSIFVQSRNCNYHHGFHPTTVCKIPSGCSVKIFNNQEFAQILAQSVNHGFETVYELTKMCTIRMSFVKGWGAKYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K0U3</accession>
    <name>A0A9J7K0U3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CMRF35-like molecule 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100760538</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CD300 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304058.1">
        <property type="nucleotide sequence ID" value="XM_035448167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K0U3"/>
    <dbReference type="GeneID" id="100760538"/>
    <dbReference type="KEGG" id="cge:100760538"/>
    <dbReference type="OrthoDB" id="8920197at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05716">
        <property type="entry name" value="IgV_pIgR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000370">
        <property type="entry name" value="CMRF35-like molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050671">
        <property type="entry name" value="CD300_family_receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860:SF101">
        <property type="entry name" value="CMRF35-LIKE MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860">
        <property type="entry name" value="POLYMERIC-IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039912711" evidence="13">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035304058.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25292" checksum="038C88F3F1EE74FF" modified="2023-06-28" version="1">MWLFPALLLFLPGCSTAQGAITGPSIVRGQERGSLTVRCRYDSRWKDNKKYWCRGADLNACEILVKTNTSEKLVKNRVSIRDDQIDLIFTVTMEDLRISDAGIYWCGIDRVGYDPSFKVNVNIDPEVSTVIMTTMAPVLTPTLSTRENTGNHGETQTSAPTWSLLSSIYFQLLVFLEVPLLLSMLSAVLWVNRPQRCSGGGEVGLEKVQSSDVRFPQVPTEFVNHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KFY2</accession>
    <name>A0A9J7KFY2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ephrin-B2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">EPH-related receptor tyrosine kinase ligand 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">HTK ligand</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC113838584</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18 19">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309427.1">
        <property type="nucleotide sequence ID" value="XM_035453536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KFY2"/>
    <dbReference type="GeneID" id="113838584"/>
    <dbReference type="KEGG" id="cge:113838584"/>
    <dbReference type="OrthoDB" id="6250301at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000020">
        <property type="entry name" value="Ephrin-B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF18">
        <property type="entry name" value="EPHRIN-B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039911228" description="Ephrin-B2" evidence="22">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="23">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035309427.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32704" checksum="89F9F12990D3E362" modified="2023-06-28" version="1">MAMAGSRRVSVWMSYWGLWMVSCTTAISSPTVLEPIYWNSSNSRFLPGQGLILYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDRDQADRCIIKKKKKTLLNCSRPHRDVKFTIKFQEFSNSIWGLEFQKNKDYYIISTSNGSLEGLNIQEGGVCQTRAMKIIMKVGQGSSTDGNSAGHSRNNLGYKVALFAGIISGCIVFIVIIITLVVLLLKYRRRHRKHSRQHSTTPKRGGNHSGWEPSDVLIPLKIADSVSRPHYEKVSGDYGHPVYIAQEMPPQNPANIYYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3GRR1</accession>
    <name>G3GRR1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cyclin-dependent kinase 10</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cell division protein kinase 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Cdk10</name>
        <name evidence="24" type="ORF">I79_000204</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="JH000004">
        <property type="protein sequence ID" value="EGV94055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003495125.1">
        <property type="nucleotide sequence ID" value="XM_003495077.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266414.1">
        <property type="nucleotide sequence ID" value="XM_027410613.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSCGRP00001014001.1"/>
        <property type="gene ID" value="ENSCGRG00001014991.1"/>
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    <dbReference type="GeneID" id="100762088"/>
    <dbReference type="KEGG" id="cge:100762088"/>
    <dbReference type="CTD" id="8558"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVARATN"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell projection organization"/>
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        <property type="term" value="P:negative regulation of cilium assembly"/>
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        <property type="entry name" value="cyclin-dependent kinase 10 isoform X2"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="CDK"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044093">
        <property type="entry name" value="STKc_CDK10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="24" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="24" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 24 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="39"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGV94055.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014001.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027266414.1"/>
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    </evidence>
    <sequence length="360" mass="40974" checksum="36392CB86E32F925" modified="2011-11-16" version="1">MAEVDLESDQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIMLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLAGQYSLRKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPAATEGQNKRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3GTL8</accession>
    <name>G3GTL8_CRIGR</name>
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        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase-like</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100753272</name>
        <name evidence="13" type="ORF">I79_001003</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JH000020">
        <property type="protein sequence ID" value="EGV91731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003495808.1">
        <property type="nucleotide sequence ID" value="XM_003495760.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258162.1">
        <property type="nucleotide sequence ID" value="XM_027402361.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GTL8"/>
    <dbReference type="STRING" id="10029.G3GTL8"/>
    <dbReference type="PaxDb" id="10029-XP_007629747.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009973.1">
        <property type="protein sequence ID" value="ENSCGRP00001006357.1"/>
        <property type="gene ID" value="ENSCGRG00001008567.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753272"/>
    <dbReference type="KEGG" id="cge:100753272"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00920000149170"/>
    <dbReference type="OMA" id="YSPYWTD"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000105">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000043">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="75"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV91731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027258162.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35571" checksum="805FC903DA340E0F" modified="2011-11-16" version="1">MDQRVDNDAEAWLQLKPVEPLPSQCCGSGCSPCVFDLYSRDLERWEAARARNDRSLLSGKQSPETQGCSTKLSPETFLAFHISAIEKLTKDTLRVRFTLPGNNQLGLHPGQHLILRGIADGLEIQRAYTPISPVTAEGYFDVLIKCYQAGLMSQYVESWRTGDTAFWRGPFGSFLYEPNKYGELLMLAAGTGLAPMVPILHSITDNADDETFVTLVCCFKTFESIYLKTFLQEQARFWNVRTFFVLSQEVSPEQLPWSYREKTHFGRLGQELVDELVACCRRKPFTLVCGSSSFTKDMARCLLSAGLTEDSYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G3H2H2</accession>
    <name>G3H2H2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-crystallin B chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alpha(B)-crystallin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 27 28 29 30 31 32 33 34 35" type="primary">Cryab</name>
        <name evidence="23" type="ORF">I79_004385</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27 28 29" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27 28 29">17A/GY</strain>
            <tissue evidence="27 28 29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17 19 20">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000115">
        <property type="protein sequence ID" value="EGW03814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267956.1">
        <property type="nucleotide sequence ID" value="XM_027412155.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271650.1">
        <property type="nucleotide sequence ID" value="XM_027415849.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299571.1">
        <property type="nucleotide sequence ID" value="XM_035443680.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299572.1">
        <property type="nucleotide sequence ID" value="XM_035443681.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299573.1">
        <property type="nucleotide sequence ID" value="XM_035443682.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299574.1">
        <property type="nucleotide sequence ID" value="XM_035443683.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299575.1">
        <property type="nucleotide sequence ID" value="XM_035443684.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299576.1">
        <property type="nucleotide sequence ID" value="XM_035443685.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299577.1">
        <property type="nucleotide sequence ID" value="XM_035443686.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299578.1">
        <property type="nucleotide sequence ID" value="XM_035443687.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303467.1">
        <property type="nucleotide sequence ID" value="XM_035447576.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303469.1">
        <property type="nucleotide sequence ID" value="XM_035447578.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303471.1">
        <property type="nucleotide sequence ID" value="XM_035447580.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303472.1">
        <property type="nucleotide sequence ID" value="XM_035447581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303476.1">
        <property type="nucleotide sequence ID" value="XM_035447585.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303480.1">
        <property type="nucleotide sequence ID" value="XM_035447589.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303481.1">
        <property type="nucleotide sequence ID" value="XM_035447590.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303483.1">
        <property type="nucleotide sequence ID" value="XM_035447592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H2H2"/>
    <dbReference type="SMR" id="G3H2H2"/>
    <dbReference type="STRING" id="10029.G3H2H2"/>
    <dbReference type="PaxDb" id="10029-XP_007619114.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018060.1">
        <property type="protein sequence ID" value="ENSCGRP00001013823.1"/>
        <property type="gene ID" value="ENSCGRG00001014861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772623"/>
    <dbReference type="KEGG" id="cge:100772623"/>
    <dbReference type="CTD" id="1410"/>
    <dbReference type="eggNOG" id="KOG3591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157434"/>
    <dbReference type="OMA" id="FRDWWED"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060561">
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        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
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        <property type="term" value="P:protein stabilization"/>
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        <property type="term" value="P:response to heat"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:response to hydrogen peroxide"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to hypoxia"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06498">
        <property type="entry name" value="ACD_alphaB-crystallin_HspB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000011">
        <property type="entry name" value="Alpha-crystallin B chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
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    <dbReference type="InterPro" id="IPR037882">
        <property type="entry name" value="ACD_alphaB-crystallin"/>
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    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
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    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
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    <dbReference type="InterPro" id="IPR003090">
        <property type="entry name" value="Alpha-crystallin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF5">
        <property type="entry name" value="ALPHA-CRYSTALLIN B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00525">
        <property type="entry name" value="Crystallin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACRYSTALLIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 17" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="22">
        <location>
            <begin position="56"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018516"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
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        <source>
            <dbReference type="RuleBase" id="RU003616"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
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            <dbReference type="RefSeq" id="XP_027267956.1"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035299571.1"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035299572.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035299575.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035299576.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035299577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="RefSeq" id="XP_035299578.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20075" checksum="BD1CC5B291493038" modified="2011-11-16" version="1">MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFSTATSLSPFYLRPPSFLRAPSWIDTGLSEMRMEKDRFSVNLDVKHFSPEELKVKVLGDVVEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQASGPERTIPITREEKPAVTAAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3H9A5</accession>
    <name>G3H9A5_CRIGR</name>
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        <recommendedName>
            <fullName evidence="11">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC103162312</name>
        <name evidence="12" type="ORF">I79_006971</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>pyruvate(out) + H(+)(out) = pyruvate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64720"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000225">
        <property type="protein sequence ID" value="EGV92209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298400.1">
        <property type="nucleotide sequence ID" value="XM_035442509.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310655.1">
        <property type="nucleotide sequence ID" value="XM_035454764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H9A5"/>
    <dbReference type="STRING" id="10029.G3H9A5"/>
    <dbReference type="PaxDb" id="10029-XP_007648894.1"/>
    <dbReference type="GeneID" id="103162312"/>
    <dbReference type="KEGG" id="cge:103162312"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H9A5"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV92209.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035298400.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3HHI2</accession>
    <name>G3HHI2_CRIGR</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="10 13" type="primary">Nkx6-3</name>
        <name evidence="9" type="ORF">I79_010101</name>
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    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000379">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027395227.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HHI2"/>
    <dbReference type="PaxDb" id="10029-XP_007608061.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023181.1">
        <property type="protein sequence ID" value="ENSCGRP00001018937.1"/>
        <property type="gene ID" value="ENSCGRG00001018532.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100751652"/>
    <dbReference type="CTD" id="157848"/>
    <dbReference type="eggNOG" id="KOG0847">
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    <dbReference type="GeneTree" id="ENSGT00940000160545"/>
    <dbReference type="OMA" id="EMKAPMC"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of stomach neuroendocrine cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:stomach neuroendocrine cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NK6 homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
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    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF20">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-6.3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="199"/>
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        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV95028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018937.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027251028.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28747" checksum="54F0BE07ACFFF5F6" modified="2011-11-16" version="1">MESNLQGTFLLNNTQLAQFSEMKAPMCQYSVQNSFYKLNPPGLGPQLAAGTPHGITDILSRPVATPNSSLLSGYPHVAGFGGLGSQGVYYGPQVGSFSKAGNEYPTRTRNCWADTGQDWRGGARPCSNTPDPLSDTIHKKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALEPSSSTPRAQGGAGGDRAASENEDDEYNKPLDPDSDDEKIRLLLRKHRAAFSVLSLGAHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3HLY0</accession>
    <name>G3HLY0_CRIGR</name>
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        <recommendedName>
            <fullName evidence="10">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Tubg1</name>
        <name evidence="13" type="ORF">I79_011724</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000499">
        <property type="protein sequence ID" value="EGW08052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504708.1">
        <property type="nucleotide sequence ID" value="XM_003504660.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283914.1">
        <property type="nucleotide sequence ID" value="XM_027428113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HLY0"/>
    <dbReference type="SMR" id="G3HLY0"/>
    <dbReference type="STRING" id="10029.G3HLY0"/>
    <dbReference type="PaxDb" id="10029-XP_007618447.1"/>
    <dbReference type="GeneID" id="100759432"/>
    <dbReference type="KEGG" id="cge:100759432"/>
    <dbReference type="CTD" id="7283"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HLY0"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000010">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW08052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027283914.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51101" checksum="A8F1068D12D0C88A" modified="2011-11-16" version="1">MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNLIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQFDKLRKREAFMEQFRKEDIFKDNFDEMDTSREIVQQLIDEYHAATRPDYISWGTQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3HPY6</accession>
    <name>G3HPY6_CRIGR</name>
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        <submittedName>
            <fullName evidence="4">RIKEN cDNA 0610030E20 gene</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">UPF0561 protein C2orf68 homolog</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">UPF0561 protein C2orf68-like</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="primary">CUNH2orf68</name>
        <name evidence="4" type="synonym">C8H2orf68</name>
        <name evidence="3" type="ORF">I79_012872</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0561 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000593">
        <property type="protein sequence ID" value="EGV93189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505675.1">
        <property type="nucleotide sequence ID" value="XM_003505627.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285293.1">
        <property type="nucleotide sequence ID" value="XM_027429492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HPY6"/>
    <dbReference type="PaxDb" id="10029-XP_007625487.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024288.1">
        <property type="protein sequence ID" value="ENSCGRP00001020044.1"/>
        <property type="gene ID" value="ENSCGRG00001019313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773330"/>
    <dbReference type="KEGG" id="cge:100773330"/>
    <dbReference type="CTD" id="137432231"/>
    <dbReference type="eggNOG" id="ENOG502S396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FCLEYEG"/>
    <dbReference type="OrthoDB" id="10033037at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018888">
        <property type="entry name" value="UPF0561"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34256">
        <property type="entry name" value="UPF0561 PROTEIN C2ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34256:SF1">
        <property type="entry name" value="UPF0561 PROTEIN C2ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10573">
        <property type="entry name" value="UPF0561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV93189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027285293.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18700" checksum="EF1CB70937704ACA" modified="2011-11-16" version="1">MEAARDPGPGLCCKPGGRLDMSHGFVHHIRRNQIARDDYDKKVKQAAKEKARRRHTPAPTRPRKPDLQVYLPRHRDGSAHLVNPDCEESGESSSSGSSELEPPGRQLFCLEYEADSGEVTSVIVYQDDDPKRVSEEISAHTPLDPAMQEALRVRIQEELAKRQSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3HQ86</accession>
    <name>G3HQ86_CRIGR</name>
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        <recommendedName>
            <fullName evidence="1 11">BH3-interacting domain death agonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Bid</name>
        <name evidence="13" type="ORF">I79_012981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Induces caspase activation and apoptosis. Allows the release of cytochrome c.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">Induces caspases and apoptosis. Counters the protective effect of BCL2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2. Interacts with PLEKHN1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with ITCH. Interacts with MTCH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGW04925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505770.1">
        <property type="nucleotide sequence ID" value="XM_003505722.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285127.1">
        <property type="nucleotide sequence ID" value="XM_027429326.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HQ86"/>
    <dbReference type="STRING" id="10029.G3HQ86"/>
    <dbReference type="PaxDb" id="10029-XP_007627352.1"/>
    <dbReference type="GeneID" id="100754606"/>
    <dbReference type="KEGG" id="cge:100754606"/>
    <dbReference type="CTD" id="637"/>
    <dbReference type="eggNOG" id="ENOG502SAN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HQ86"/>
    <dbReference type="OrthoDB" id="9941774at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902110">
        <property type="term" value="P:positive regulation of mitochondrial membrane permeability involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090200">
        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000010">
        <property type="entry name" value="BH3-interacting domain death agonist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020728">
        <property type="entry name" value="Bcl2_BH3_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010479">
        <property type="entry name" value="BID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35447">
        <property type="entry name" value="BH3-INTERACTING DOMAIN DEATH AGONIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35447:SF1">
        <property type="entry name" value="BH3-INTERACTING DOMAIN DEATH AGONIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06393">
        <property type="entry name" value="BID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038018">
        <property type="entry name" value="BID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01259">
        <property type="entry name" value="BH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW04925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027285127.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22003" checksum="1B134AFA4A8BB7F0" modified="2011-11-16" version="1">MDSQVSNGSGLDTEHITNLLVFGFLQNSKYHFHRELEVLGQELPVPVYLDADEDELQTDGSRASRSYHGRIQPDSESQEDVIQRIAHHLAQVGDELNHSIQPTLVRQLAAQFMNVSLSEEDRRNCLAKALDEVKTAFPRDMENEKAMLIMTLLLAKSVASHEPSLLRDVFRTTVNFINQNLFTSVRNLLRNGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3HRH5</accession>
    <name>G3HRH5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Med19</name>
        <name evidence="6" type="synonym">MED19</name>
        <name evidence="8" type="ORF">I79_013446</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000637">
        <property type="protein sequence ID" value="EGW09615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506199.1">
        <property type="nucleotide sequence ID" value="XM_003506151.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278482.1">
        <property type="nucleotide sequence ID" value="XM_027422681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HRH5"/>
    <dbReference type="STRING" id="10029.G3HRH5"/>
    <dbReference type="PaxDb" id="10029-XP_007626163.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013907.1">
        <property type="protein sequence ID" value="ENSCGRP00001009688.1"/>
        <property type="gene ID" value="ENSCGRG00001011747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755285"/>
    <dbReference type="KEGG" id="cge:100755285"/>
    <dbReference type="CTD" id="219541"/>
    <dbReference type="eggNOG" id="KOG4043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRFCGSK"/>
    <dbReference type="OrthoDB" id="10044050at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW09615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027278482.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26303" checksum="A63D10B156CB7AEC" modified="2011-11-16" version="1">MENFTALFGAQADPPPPPSALGFGPGKPPPPPPPPPGGGPGTAPPPTATSAPAGADKSAAGSGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFNPITGTMLSGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3HRK4</accession>
    <name>G3HRK4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20 21" type="primary">Rab5b</name>
        <name evidence="16" type="ORF">I79_013509</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21">17A/GY</strain>
            <tissue evidence="20 21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Early endosome membrane</location>
            <topology evidence="13">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="EMBL" id="JH000638">
        <property type="protein sequence ID" value="EGW12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506243.1">
        <property type="nucleotide sequence ID" value="XM_003506195.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007644892.1">
        <property type="nucleotide sequence ID" value="XM_007646702.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247952.1">
        <property type="nucleotide sequence ID" value="XM_027392151.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247953.1">
        <property type="nucleotide sequence ID" value="XM_027392152.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HRK4"/>
    <dbReference type="SMR" id="G3HRK4"/>
    <dbReference type="STRING" id="10029.G3HRK4"/>
    <dbReference type="PaxDb" id="10029-XP_007619071.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000555.1">
        <property type="protein sequence ID" value="ENSCGRP00001000531.1"/>
        <property type="gene ID" value="ENSCGRG00001000428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768837"/>
    <dbReference type="KEGG" id="cge:100768837"/>
    <dbReference type="CTD" id="5869"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160756"/>
    <dbReference type="OMA" id="DEEGLMW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048227">
        <property type="term" value="P:plasma membrane to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000180">
        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027247952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027247953.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23734" checksum="D47AD82166C8B591" modified="2011-11-16" version="1">MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRNRGVDLHEQSQQNKSQCCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3HTH2</accession>
    <name>G3HTH2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Timm22</name>
        <name evidence="10" type="ORF">I79_014197</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH000697">
        <property type="protein sequence ID" value="EGV96744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506768.1">
        <property type="nucleotide sequence ID" value="XM_003506720.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282503.1">
        <property type="nucleotide sequence ID" value="XM_027426702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HTH2"/>
    <dbReference type="STRING" id="10029.G3HTH2"/>
    <dbReference type="PaxDb" id="10029-XP_007624573.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013549.1">
        <property type="protein sequence ID" value="ENSCGRP00001009346.1"/>
        <property type="gene ID" value="ENSCGRG00001011484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762051"/>
    <dbReference type="KEGG" id="cge:100762051"/>
    <dbReference type="CTD" id="29928"/>
    <dbReference type="eggNOG" id="KOG3225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016067"/>
    <dbReference type="OMA" id="VNPNMAD"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV96744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027282503.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="20137" checksum="455372EE9AAE79B2" modified="2011-11-16" version="1">MAATAPSAGASAAESATSAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPSKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGIFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3I2N9</accession>
    <name>G3I2N9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16 20">Potassium channel subfamily K member 5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Potassium channel, subfamily K, member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Kcnk5</name>
        <name evidence="16" type="ORF">I79_017682</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001141">
        <property type="protein sequence ID" value="EGW09997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003509546.1">
        <property type="nucleotide sequence ID" value="XM_003509498.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243396.1">
        <property type="nucleotide sequence ID" value="XM_027387595.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I2N9"/>
    <dbReference type="STRING" id="10029.G3I2N9"/>
    <dbReference type="PaxDb" id="10029-XP_007621618.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025485.1">
        <property type="protein sequence ID" value="ENSCGRP00001021241.1"/>
        <property type="gene ID" value="ENSCGRG00001020146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760223"/>
    <dbReference type="KEGG" id="cge:100760223"/>
    <dbReference type="CTD" id="8645"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156775"/>
    <dbReference type="OMA" id="YWNWPNA"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of resting membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Potassium channel subfamily K member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF241">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
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        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="182"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="172"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="RuleBase" id="RU003857"/>
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    <evidence type="ECO:0000256" key="13">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF07885"/>
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            <dbReference type="EMBL" id="EGW09997.1"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021241.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027243396.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3I4C0</accession>
    <name>G3I4C0_CRIGR</name>
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    <gene>
        <name evidence="17 20" type="primary">Dck</name>
        <name evidence="16" type="ORF">I79_018297</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyadenosine + ATP = dAMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23452"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.76"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
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            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="2.7.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyguanosine + ATP = dGMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19201"/>
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            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.113"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCK/DGK family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGW00581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_003510099.1">
        <property type="nucleotide sequence ID" value="XM_003510051.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245040.1">
        <property type="nucleotide sequence ID" value="XM_027389239.2"/>
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    <dbReference type="AlphaFoldDB" id="G3I4C0"/>
    <dbReference type="STRING" id="10029.G3I4C0"/>
    <dbReference type="PaxDb" id="10029-XP_007622296.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018398.1">
        <property type="protein sequence ID" value="ENSCGRP00001014161.1"/>
        <property type="gene ID" value="ENSCGRG00001015116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751299"/>
    <dbReference type="KEGG" id="cge:100751299"/>
    <dbReference type="CTD" id="1633"/>
    <dbReference type="eggNOG" id="KOG4235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157321"/>
    <dbReference type="OMA" id="EAMVMTP"/>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:deoxyadenosine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:deoxycytidine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:deoxyguanosine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
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        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF19">
        <property type="entry name" value="DEOXYCYTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="28"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="86"/>
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        <location>
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        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
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            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="197"/>
        </location>
        <ligand>
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            <begin position="240"/>
            <end position="242"/>
        </location>
        <ligand>
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        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
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            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00048675"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW00581.1"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014161.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3I4K3</accession>
    <name>G3I4K3_CRIGR</name>
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        <recommendedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 87</fullName>
        </recommendedName>
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    <gene>
        <name evidence="14" type="primary">Ccdc87</name>
        <name evidence="10" type="ORF">H671_3g10134</name>
        <name evidence="9" type="ORF">I79_018385</name>
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    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CCDC87 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001255">
        <property type="protein sequence ID" value="EGW06366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE673007">
        <property type="protein sequence ID" value="ERE78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510197.1">
        <property type="nucleotide sequence ID" value="XM_003510149.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264461.1">
        <property type="nucleotide sequence ID" value="XM_027408660.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I4K3"/>
    <dbReference type="PaxDb" id="10029-XP_007608929.1"/>
    <dbReference type="GeneID" id="100761101"/>
    <dbReference type="KEGG" id="cge:100761101"/>
    <dbReference type="CTD" id="55231"/>
    <dbReference type="eggNOG" id="ENOG502QQN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67750at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1520:FF:000003">
        <property type="entry name" value="Coiled-coil domain-containing protein 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037383">
        <property type="entry name" value="CCDC87"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16078">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16078:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0278">Fertilization</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0744">Spermatogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW06366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ERE78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027264461.1"/>
        </source>
    </evidence>
    <sequence length="861" mass="98994" checksum="EE228BE9D47D2234" modified="2011-11-16" version="1">MDLNNQEPDLSPIYHRLLSPLSLFPRKVTTPPEPPKGPPQKFSPLQSIPLAKLKVGQLCRLVSKRLAGSGRAARVTPKDRLRLTRVILEELKCSWQEPPTEPILNYENNQKLRKRLESYVLICSEQLFIRYLHLLVILPPTRKVFTEAAILSRLVVNLARDCTIFLTSPDVYRFLLADFQTLLNLEQTPGSISKLRPPACPPGTFKLCPIPWPHNTGLDQVPCSSLNLTYLVQLSRPYDFSSEPEPDPVKELKSIPQLKGIKQLLLVPCTKKEKEVEVTPSAMTPLPSHSPGGSEISPFPTSPIYPRLPRGQSMPCLREGWNLADELGLPPLSPHPLTPLVLAPERKPLLFEEMVAKDLKQKTKSMGMEWAHYPPMELGMGLPPLLGVLTRHLTAQQHIENLRQMLKSLQDEEALGKWYLHPPRITPLYPQPVTITVKLQNQVVVQVATVQLSDRYFYDTFHVEGAGVLYNHLTGELDCKAIEEMDADLLTGNSTKEIYKELMTRVSHSHLSFDEGPQVEPSADRDWSNYLFSTFLNQDKQTPINKDLVGFYPRRTSMQQLLPEKKPSPTVVQMRKSWEKRPNKGVWVNWWNTSLSAEDYLKYLDTQETDFLHVIFQIHEEEVPVEIPAPVKRSLEIQHPPPLLEDEEPDFVPGEWNWSSVLEDSFIFSDRGPGKASILNLQQRLERLWDALEVPVQSRLDMVIKYSSKARLQQLPALIRAWERVLKPIQKRELLLARLEWFERQASDPNRFFQKSDLILSRFLEENQSRSYIQRKLNLMESSLITLLKKIESVFGEPVTFKGRRYLDKMKQDKVEMLYWLQQQRRVRNLIRAQKAFYQSSMFTRGSSQSLIAPGNTPVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3IHT4</accession>
    <name>G3IHT4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDP-D-glucose phosphorylase 1</fullName>
            <ecNumber evidence="5">2.7.7.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20 21" type="primary">Gdpgp1</name>
        <name evidence="16" type="ORF">I79_023390</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21">17A/GY</strain>
            <tissue evidence="20 21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30387"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:62230"/>
            <dbReference type="EC" id="2.7.7.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GDPGP1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.78" evidence="5"/>
    <dbReference type="EMBL" id="JH002857">
        <property type="protein sequence ID" value="EGW06016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007652592.1">
        <property type="nucleotide sequence ID" value="XM_007654402.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016818950.1">
        <property type="nucleotide sequence ID" value="XM_016963461.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264032.1">
        <property type="nucleotide sequence ID" value="XM_027408231.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264033.1">
        <property type="nucleotide sequence ID" value="XM_027408232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IHT4"/>
    <dbReference type="STRING" id="10029.G3IHT4"/>
    <dbReference type="PaxDb" id="10029-XP_007619159.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015065.1">
        <property type="protein sequence ID" value="ENSCGRP00001010839.1"/>
        <property type="gene ID" value="ENSCGRG00001012639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772319"/>
    <dbReference type="KEGG" id="cge:100772319"/>
    <dbReference type="CTD" id="390637"/>
    <dbReference type="eggNOG" id="KOG2720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016718"/>
    <dbReference type="OMA" id="GIQWPRT"/>
    <dbReference type="OrthoDB" id="417175at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080048">
        <property type="term" value="F:GDP-D-glucose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026506">
        <property type="entry name" value="GDPGP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058865">
        <property type="entry name" value="GDPGP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058866">
        <property type="entry name" value="GDPGP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20884">
        <property type="entry name" value="GDP-D-GLUCOSE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20884:SF8">
        <property type="entry name" value="GDP-D-GLUCOSE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26216">
        <property type="entry name" value="GDPGP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26217">
        <property type="entry name" value="GDPGP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDPGP1-like N-terminal" evidence="15">
        <location>
            <begin position="58"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="GDPGP1-like C-terminal" evidence="14">
        <location>
            <begin position="241"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF26217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW06016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027264032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027264033.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42032" checksum="C6142FBF4FA1077A" modified="2011-11-16" version="1">MAVPHDSQETSYLLPPNPEDWEEQGIPDFVYGQKDLAGKGVQWPRNAGSTLDSLPRSRFDSALCSAWKQRVELGLFRYRLEDLQTQILPGSVGFVAQLNIERGVQRRPPQNIKSVRQEFDPEQFNFTKIRPGEVLFRLQREPNGPAASKQEDIFVVINVSPLEWGHVLLVPEPAHGLPQRLLPGVLRAGLEAVLLSLHPGFRVGFNSLGGLASVNHLHLHGYYLAHPLPVEGAPSTPLDPKACIYLLQNLPAPGFLFYTSGPGPDLEALISRVCRATDYLSDHEIAHNLFVTRGAPPGQASPSSDLTGIRVILWARKSSFGIKDSGAFNVALCELAGHLPVKTSQDFGSLTEAAAMALIQDCLLPQTQADEVQAALVALMAQEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3IK04</accession>
    <name>G3IK04_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 14 15 16">Solute carrier family 35 member E2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Solute carrier family 35, member E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14 15 16" type="primary">LOC100773575</name>
        <name evidence="10" type="ORF">I79_024196</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15 16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15 16">17A/GY</strain>
            <tissue evidence="14 15 16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TPT transporter family. SLC35E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH003456">
        <property type="protein sequence ID" value="EGW13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514896.1">
        <property type="nucleotide sequence ID" value="XM_003514848.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007653085.1">
        <property type="nucleotide sequence ID" value="XM_007654895.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254357.1">
        <property type="nucleotide sequence ID" value="XM_027398556.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254358.1">
        <property type="nucleotide sequence ID" value="XM_027398557.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254359.1">
        <property type="nucleotide sequence ID" value="XM_027398558.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IK04"/>
    <dbReference type="STRING" id="10029.G3IK04"/>
    <dbReference type="PaxDb" id="10029-XP_007606846.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032106.1">
        <property type="protein sequence ID" value="ENSCGRP00001027858.1"/>
        <property type="gene ID" value="ENSCGRG00001024737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773575"/>
    <dbReference type="KEGG" id="cge:100773575"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159351"/>
    <dbReference type="OMA" id="YFPCGMY"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001835">
        <property type="term" value="P:blastocyst hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="9">
        <location>
            <begin position="73"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGW13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027254357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027254358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027254359.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="44218" checksum="13CDF294985A3986" modified="2011-11-16" version="1">MSSAKSQGPEETVPDCEEELKGKTLLTWGPLFGHRSEKIVFTKGDGSPEESLLTVTITETTVIESDLGVWSSRALIYLTLWFFFSFCTLFLNKYILSLLEGEPSMLGAVQMLSTTLIGCVKIFVPCCLYQHKTRLSYPPNFIMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGLLVNLSLIPVMGGLALCTATEISFNILGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVALLIPAWTFFMDVPVIGRSGKSFSYSQDIVLLLLTDGALFHLQSVTAYALMGKISPVTFSVASTVKHALSIWLSIIVFGNKITSLSAIGTILVTMGVLLYNKARQYQQETMQSLATATSRGPEDDTESLVPLDSRQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IAK5</accession>
    <name>A0A061IAK5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">N-lysine methyltransferase SETD6</fullName>
            <ecNumber evidence="12">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Setd6</name>
        <name evidence="15" type="ORF">H671_3g9299</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67808"/>
            <dbReference type="Rhea" id="RHEA-COMP:17357"/>
            <dbReference type="Rhea" id="RHEA-COMP:17358"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51737"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer, homodimer and homotrimer; these structures are stabilized in the presence of S-adenosyl-L-methionine (SAM).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KE671818">
        <property type="protein sequence ID" value="ERE79831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261519.1">
        <property type="nucleotide sequence ID" value="XM_027405718.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IAK5"/>
    <dbReference type="GeneID" id="100761490"/>
    <dbReference type="KEGG" id="cge:100761490"/>
    <dbReference type="CTD" id="79918"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000004">
        <property type="entry name" value="N-lysine methyltransferase SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1420.10:FF:000002">
        <property type="entry name" value="N-lysine methyltransferase SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 12 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="76"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE79831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027261519.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="54872" checksum="AD6A63C5769EA077" modified="2014-09-03" version="1">MAAPAKRARVSGGSPLTTPCPVRRVTRAPLSPPAPGRGHATCFSPLAAWPRGGQSDGDAVAGFLRWCAGVGLELSPKVAVSRQGTVAGYGMVARESVQPGELLFAVPRSALLSPHTCSISGLLERERGALQSLSGWVPLLLALLHELQAPASPWSPYFALWPELGRLEHPMFWPEEERRRLLQGTGVPEAVEKDLVNITSEYHSIVLPFMEAHSDLFSPTVRSLELYRQLVALVMAYSFQEPLEEEDDDEKEPNSPLMVPAADLLNHIANHNANLEYSADYLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFAEPYPDNTDDTADIQMVTVRDAALQGTKDEAEKLLLCERWDFLCKLEMVGEEGAFVIGHEEVLTEEELATTLKVLCMPAEEFRNYKEQAGQGEEEREEVSLAIANIPKLQASWKRLLRDSVLLTLQTYATDLKTEQDLLSNKEVYAKLSWREQQALQVRYGQKMILHQVLELTSSFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IBA0</accession>
    <name>A0A061IBA0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15 18">RIMS-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100755463</name>
        <name evidence="15" type="ORF">H671_4g11728</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIMBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE674171">
        <property type="protein sequence ID" value="ERE76569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269008.1">
        <property type="nucleotide sequence ID" value="XM_027413207.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100755463"/>
    <dbReference type="KEGG" id="cge:100755463"/>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002177">
        <property type="term" value="C:manchette"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030156">
        <property type="term" value="F:benzodiazepine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000006">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000072">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000232">
        <property type="entry name" value="RIMS-binding protein 3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000246">
        <property type="entry name" value="RIMS-binding protein 3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057950">
        <property type="entry name" value="RIMB1/RIM3A-C-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF21">
        <property type="entry name" value="RIMS-BINDING PROTEIN 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25523">
        <property type="entry name" value="Ig_RIMBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25566">
        <property type="entry name" value="RIMB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="822"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="985"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1423"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1539"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="680"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="741"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1370"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="553"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE76569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027269008.1"/>
        </source>
    </evidence>
    <sequence length="1609" mass="177578" checksum="7F90A1599F226F54" modified="2014-09-03" version="1">MTKDSPTPLGGGRASPKKPSSPGPAAAVLEEQRRELEKLRAELEAERARGRAERRRFGAQARQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAELRQLQQLLHQERDVVVRQARELQRQLAQELVNRGYCGRSGASEASAAQCRCRLQEVLALLRWETDGEQAARIRHLQAALDSERQLFLKYILEHFRWQPALSEPADPQVVHSLDEPPIGAQSNTGGTQKPARRLGSLESLRTGARVSSPDDLLPTRASSLESLATAHPCSLDSTRSCPRAPESELGASSTSASRPGTSSPPPPPQLPSKHKKPSDLKGESSENKPCEAPTLSPPGQDYHELVKQNSELAEALQVLVRRCCDLREENLQLRCTGFSNETDEKVKWLKVKHAELTDLAQRLEDRARKLQETNLQAVSAPVPGESLESLDLGQVFAHQRTQDPSEQADALQAKDLQIEALRRECHLLQAHIAADLGSSSLPGEGATCAQWCNISDLDRLQRESQREVLRLQRQLTLHQSKAGARAEAGSLSSPSEIARYEVQALEEKLGAQRRECEELSAQAAAAERRYEEAEAQLQAALHKGARLSEENARLQALASWVKKMADENSNVPRQQNHARQRQELEATSLLAEQLLQQAGYVQDGWQQLQYYQNKAPSDLLASGKEIQGLQCQPGHPLETSETTQASESQARDSRRPKFKPKSEEHALSLPTRDIEPPVCLSQQENSVTLGEPAGIPQVSEKNSISQPLDSKPQAKKTSSQSNSSSEVESMWATVPSCLSLDMDTASEVDDLEPDSVSSPLEMRSSEAPTTPKLRIFLARCSYNPFEGSKEHSQGQLPLTAGDYVYVFGDMDEDGFYEGELVTGQRGLVPSNLVEQISGSPILNHLLPKSPDICPTALPPEQTKALKKGSLSLGEFKGSLETGLCQVRRTDSKTDVAIEILETKTEACWLGLKPSMEEQSVSRPLLEAKGVFCLAPMQLQLQNVTATSATITWASGSNRYPHVVYLEDEEHTLTPSGVSCYTFQGLHPGTRYRVRVGVQLPRDLLQVLWETMSSTVTFDTPLAGPPDPPLDVLVEHHASPGLLVVSWLPVTIDSAGSSNGVQVTGYAVYVDGFKVTEVADATAGNTLLEFSQLRVPLACQKVSVRTMSLYGESLDSVPAQIPEDCFSCYPFLDTFPFSYMDGDPLTCRVISLSTKTSPHTPGSCGEPQVKFVEAFPKDPTRKHSPISNLISERADNQVQGPAETWKDYEKGLSLQESPQNLKPPLPFGQSGVEEGHSPHMCINGCPAPGFIHLSPEIGPRKVLRWEKPGLEKALQKQYDQTLPPHQQGSSQLPTADFHHVREEKAAVCLDSRCTEKLGQRKNKFQSGQTQETPGGKRECQFHKPTSVLCPVPTSKVIKMASGVPEKPETEANNPVRLFVALFDHSPLVMPVNAKAPEEELVFQKGQLLRVWGSQDPHGFYHGECNGRVGKIPGHLVVEVEVGTDQTDKRQPLPAQGHLHSEAQHEDLEGLTNSQGSLMSQGNSRTPTLWTPKTMVAALDYDPRDGRVGVRAKGKLVLRAGDVVTVYGPVDDKGFYYGEYGGHRGLVPAHLLDDLPVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IEA6</accession>
    <name>A0A061IEA6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycine N-acyltransferase-like protein</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15" type="primary">LOC100767729</name>
        <name evidence="9" type="ORF">H671_3g10036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13 14">17A/GY</strain>
            <tissue evidence="12 13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19869"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57670"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KE672907">
        <property type="protein sequence ID" value="ERE78859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262409.1">
        <property type="nucleotide sequence ID" value="XM_027406608.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262410.1">
        <property type="nucleotide sequence ID" value="XM_027406609.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262411.1">
        <property type="nucleotide sequence ID" value="XM_027406610.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297849.1">
        <property type="nucleotide sequence ID" value="XM_035441958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IEA6"/>
    <dbReference type="GeneID" id="100767729"/>
    <dbReference type="KEGG" id="cge:100767729"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047961">
        <property type="term" value="F:glycine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000075">
        <property type="entry name" value="Glycine N-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013652">
        <property type="entry name" value="Glycine_N-acyltransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015938">
        <property type="entry name" value="Glycine_N-acyltransferase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF11">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08444">
        <property type="entry name" value="Gly_acyl_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06021">
        <property type="entry name" value="Gly_acyl_tr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycine N-acyltransferase N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine N-acyltransferase C-terminal" evidence="8">
        <location>
            <begin position="205"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ERE78859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027262409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027262410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027262411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035297849.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33788" checksum="C3B544D4E9A22C65" modified="2014-09-03" version="1">MLHLRNPQMLQMLEKSLRKHLPESLKVYGTVFHMNQGNPFKLKALVDKWPDFNTVIVRPQEMADDLDPHTNTYQLYSKDPKNCLEFLGTPEAINWKQHLQIQSSQSNLNEVIMGLAAAKLVKVKRTQCILYMMPQTAKKLVPFLMADTENSHNKSGRPRPINQEMFKLSSLDVTHAALVDKYWHFGGNERSQRFIEHCIQTFPSSCLLGPEGTPVSWALMDQTGEMRMAGTVPDYRAQGLISHIIHTQTLVMDELGYPVYNHADRANKTIQKMSYTLQHVPMPCDWNQWNCVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HB38</accession>
    <name>A0A3L7HB38_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Thg1l</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer. Interacts with MFN1 and MFN2; functions as a guanyl-nucleotide exchange factor/GEF for MFN2 and also probably MFN1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="12"/>
    <dbReference type="RefSeq" id="XP_027281077.1">
        <property type="nucleotide sequence ID" value="XM_027425276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HB38"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024677.1">
        <property type="protein sequence ID" value="ENSCGRP00001020433.1"/>
        <property type="gene ID" value="ENSCGRG00001019597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763395"/>
    <dbReference type="KEGG" id="cge:100763395"/>
    <dbReference type="CTD" id="54974"/>
    <dbReference type="GeneTree" id="ENSGT00390000011705"/>
    <dbReference type="OMA" id="WKQHTEI"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990046">
        <property type="term" value="P:stress-induced mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="15">
        <location>
            <begin position="35"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="16">
        <location>
            <begin position="167"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="58"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027281077.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34865" checksum="A8FFB749DA43353D" modified="2019-02-13" version="1">MWPFSAAEIRSRLAATSVTLRRCLRLGVTMAKSKFEYVRDFEADDTCLPHCWVVVRLDGRNFHRFAEKHSFAKPNDSRALQLMTKCAQTVMEELEDIVIAYGQSDEYSFVFRRKSNWFKRRASKFMTLVASQFASSYVFYWRDYFADQPLLYPPGFDGRVVLYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQERLKGTLAGDKNEILFSQFHINYNDEPQMYRKGTVLVWQKVDEVRTQEVRLPAEMEGERMTVTRTRARPVPLYCDLIGDAFWKEHPDILSGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HM07</accession>
    <name>A0A3L7HM07_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GRB10 interacting GYF protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">GRB10-interacting GYF protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Gigyf1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the GIGYF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003510683.1">
        <property type="nucleotide sequence ID" value="XM_003510635.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272033.1">
        <property type="nucleotide sequence ID" value="XM_027416232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HM07"/>
    <dbReference type="SMR" id="A0A3L7HM07"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005186.1">
        <property type="protein sequence ID" value="ENSCGRP00001003574.1"/>
        <property type="gene ID" value="ENSCGRG00001004356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753362"/>
    <dbReference type="KEGG" id="cge:100753362"/>
    <dbReference type="CTD" id="64599"/>
    <dbReference type="GeneTree" id="ENSGT00940000159845"/>
    <dbReference type="OMA" id="FHNTGEC"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048009">
        <property type="term" value="P:insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000001">
        <property type="entry name" value="GRB10-interacting GYF protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF37">
        <property type="entry name" value="GRB10-INTERACTING GYF PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="5">
        <location>
            <begin position="473"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="669"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="858"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003574.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027272033.1"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115227" checksum="5285D420558A6845" modified="2019-02-13" version="1">MAAETLNFGPEWLRALSGGGNVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFTAVLQEEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAATSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKSARRDGARSGFEEGGAGPRKEHARSDSENWRSLREEQEEDGSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGERRRKFDFDLRGERGACGEEDGRLGGGSSHLRRCRGLDGFEDDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEEPSEGVDEEGPEAGGKEVTPLPPPEKSSSPSPLPALGPLWTTNEDGDEVVEKEPPPAEGDEMRGLSLSPGVGSPPGPPGDLEDEEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSTAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQHFLQLVGSRQLPQCTTLREKAAMGDLTPPQQQQLTAFLQQLQALKTPRGGDQNLLPTMSRSLSVPDSGPLWDLHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRLCREEKRRQQQQQQQEEQKRRQEEEELFRRKQVRQQELLLKLLQQQQATSVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQPAPREPLRAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGSSSGSLGLWEDTVKSGGNLARNLGLKNSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTTGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQEAWLSSTSLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HMX8</accession>
    <name>A0A3L7HMX8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Serine/threonine-protein kinase Nek2</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Never in mitosis A-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36 39" type="primary">Nek2</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
            <tissue evidence="39">Liver</tissue>
        </source>
    </reference>
    <reference evidence="36" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Centromere</location>
            <location evidence="4">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_007649308.2">
        <property type="nucleotide sequence ID" value="XM_007651118.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272330.1">
        <property type="nucleotide sequence ID" value="XM_027416529.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317111.1">
        <property type="nucleotide sequence ID" value="XM_035461220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HMX8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031001.1">
        <property type="protein sequence ID" value="ENSCGRP00001026755.1"/>
        <property type="gene ID" value="ENSCGRG00001023977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751300"/>
    <dbReference type="KEGG" id="cge:100751300"/>
    <dbReference type="CTD" id="4751"/>
    <dbReference type="GeneTree" id="ENSGT00940000156989"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001824">
        <property type="term" value="P:blastocyst development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051299">
        <property type="term" value="P:centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903126">
        <property type="term" value="P:negative regulation of centriole-centriole cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051988">
        <property type="term" value="P:regulation of attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046602">
        <property type="term" value="P:regulation of mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000151">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000356">
        <property type="entry name" value="Serine/threonine-protein kinase Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000310">
        <property type="entry name" value="serine/threonine-protein kinase Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="27" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="28" id="KW-0137">Centromere</keyword>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="19" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="23 33" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="24" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="18 39" id="KW-0418">Kinase</keyword>
    <keyword evidence="20" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="26" id="KW-0469">Meiosis</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0493">Microtubule</keyword>
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    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="8"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="33">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="34">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00067730"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082682"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026755.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="RefSeq" id="XP_027272330.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="51550" checksum="6015F11DC754386B" modified="2019-02-13" version="1">MPSRVEDYEVLHSIGTGSYGRCRKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKDRQYLEEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDSSFAKTFVGTPYYMSPEQMSRLSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDIITRMLNLKDYHRPSVEEILESPLIADLVAEEQRRHLERRGQRLGEPSKLQVSSPVLSELKLKEKQLQDRERALRAREDSLEQKERELCIRERLAEDKLARAESLVKNYSLLKEQRFLCLASDPDLDHPSLVMRKKVHFRGESKENTTRSENSESQLAKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HPZ8</accession>
    <name>A0A3L7HPZ8_CRIGR</name>
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        <submittedName>
            <fullName evidence="4">Kelch-like 18</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Kelch-like protein 18 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">Klhl18</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003504298.1">
        <property type="nucleotide sequence ID" value="XM_003504250.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270483.1">
        <property type="nucleotide sequence ID" value="XM_027414682.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HPZ8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026150.1">
        <property type="protein sequence ID" value="ENSCGRP00001021906.1"/>
        <property type="gene ID" value="ENSCGRG00001020613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765054"/>
    <dbReference type="CTD" id="23276"/>
    <dbReference type="OMA" id="DRWTIVT"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18457">
        <property type="entry name" value="BACK_KLHL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18247">
        <property type="entry name" value="BTB_POZ_KLHL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030603">
        <property type="entry name" value="KLHL18_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027270483.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="63800" checksum="4339519DF402E03A" modified="2019-02-13" version="1">MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREKREPCLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANRWEKCHPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTIFEGRIYVSGGHDGLQIFNSVEHYNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRWTFMAPMACHEGGVGVGCIPLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HT87</accession>
    <name>A0A3L7HT87_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100766531</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027267447.1">
        <property type="nucleotide sequence ID" value="XM_027411646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HT87"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019831.1">
        <property type="protein sequence ID" value="ENSCGRP00001015588.1"/>
        <property type="gene ID" value="ENSCGRG00001016165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766531"/>
    <dbReference type="KEGG" id="cge:100766531"/>
    <dbReference type="GeneTree" id="ENSGT00940000154131"/>
    <dbReference type="OrthoDB" id="9592300at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15234">
        <property type="entry name" value="7tmA_OR7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027267447.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34444" checksum="01351F09E531E8D3" modified="2019-02-13" version="1">MEPGNQTGIFHFFLMELTHDATMEPLIFGLFLFTYLVTILGNLLIILAVISDSHLQTPMYLFLSKLSFTDICLSTTTVPNMLKNIHTHDQSISYAGCLTQACFVLNFAVLESCVLAAMAYDRYAAICHPLNYTVIMNPNFCCLLILLSLIISIVNSLLQCLMVLRLSFCTNFQLPLFFCELAQVIKLTCSDALINYILIYLATFIFGGIPISGIIFSYTRIVSSILRISSLKGRYKAFSTCGSHFVVVSLFYGAAVGVYISSAITVSPQITTVSYMMYTVLPQMLNPFIYSLRNKDMKKALGKLITKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HVU2</accession>
    <name>A0A3L7HVU2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Potassium channel subfamily K member 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">TWIK-related arachidonic acid-stimulated potassium channel protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29 32" type="primary">Kcnk4</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
            <tissue evidence="32">Liver</tissue>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Cs(+)(in) = Cs(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78555"/>
            <dbReference type="ChEBI" id="CHEBI:49547"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Rb(+)(in) = Rb(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78547"/>
            <dbReference type="ChEBI" id="CHEBI:49847"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer; disulfide-linked. Forms heterodimers with other 2-pore domain K(+) channel subunits, such as KCNK2 and KCNK10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511330.1">
        <property type="nucleotide sequence ID" value="XM_003511282.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264252.1">
        <property type="nucleotide sequence ID" value="XM_027408451.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HVU2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028619.1">
        <property type="protein sequence ID" value="ENSCGRP00001024373.1"/>
        <property type="gene ID" value="ENSCGRG00001022320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760723"/>
    <dbReference type="KEGG" id="cge:100760723"/>
    <dbReference type="CTD" id="50801"/>
    <dbReference type="GeneTree" id="ENSGT00940000160310"/>
    <dbReference type="OMA" id="VFLKWHV"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034705">
        <property type="term" value="C:potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098782">
        <property type="term" value="F:mechanosensitive potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904551">
        <property type="term" value="P:cellular response to arachidonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050976">
        <property type="term" value="P:detection of mechanical stimulus involved in sensory perception of touch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990478">
        <property type="term" value="P:response to ultrasound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000106">
        <property type="entry name" value="Potassium channel subfamily K member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
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    <dbReference type="InterPro" id="IPR008074">
        <property type="entry name" value="2pore_dom_K_chnl_TRAAK"/>
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    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF30">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
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    <dbReference type="PRINTS" id="PR01691">
        <property type="entry name" value="TRAAKCHANNEL"/>
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    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 24 32" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 24" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="27" id="KW-0732">Signal</keyword>
    <keyword evidence="7 24 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 24" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594427" description="Potassium channel subfamily K member 4" evidence="27">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="28">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="28">
        <location>
            <begin position="181"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="283"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044657"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044691"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063569"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068468"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081382"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024373.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027264252.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43048" checksum="9A3CCD837476CD46" modified="2019-02-13" version="1">MRSTTLLALLALVLLYLVSGALVFQALEKPHEQQVQKELEDGRDKFLKDHPCVSQENLREFIKLLAKTLGGGANPDTSWTNNSNHSSAWNLGSAFFFSGTIITTVGYGNTALQTDAGRLFCIFYALVGIPLFGMLLAGVGDRLGSSLRRGIGHIEAVFLKWHVPPGLVRILSAVLFLLIGCLLFVLTPTFVFSYLESWSKLEAIYFVIVTLTTVGFGDYVPGTSSRHNSAYQPLAWFWILFGLAYFASVLTTIGNWLRAVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPSAPPPEKEQPFLPSSLPAPPGVVEPASMPVSPGSPKKAKTPSPPTASALDYPSENLAFIDESSDTQSERGCALPRAPRGRRRPNAPRKPSKPRGPGRLRDKARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I575</accession>
    <name>A0A3L7I575_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfotransferase</fullName>
            <ecNumber evidence="15">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Hs3st5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15461"/>
            <dbReference type="Rhea" id="RHEA-COMP:9830"/>
            <dbReference type="Rhea" id="RHEA-COMP:9831"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:58388"/>
            <dbReference type="ChEBI" id="CHEBI:70975"/>
            <dbReference type="EC" id="2.8.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_007642220.1">
        <property type="nucleotide sequence ID" value="XM_007644030.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257882.1">
        <property type="nucleotide sequence ID" value="XM_027402081.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I575"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018377.1">
        <property type="protein sequence ID" value="ENSCGRP00001014140.1"/>
        <property type="gene ID" value="ENSCGRG00001015101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763965"/>
    <dbReference type="KEGG" id="cge:100763965"/>
    <dbReference type="CTD" id="222537"/>
    <dbReference type="GeneTree" id="ENSGT00940000158991"/>
    <dbReference type="OMA" id="ISLYHTY"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050819">
        <property type="term" value="P:negative regulation of coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046596">
        <property type="term" value="P:regulation of viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000603">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF46">
        <property type="entry name" value="HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="16">
        <location>
            <begin position="91"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="309"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027257882.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40541" checksum="66E5A93DE4B73044" modified="2019-02-13" version="1">MLFKQQVWLRQKLLVLGSLALGSLLYLVARVGSLDRLQPICPVESRFGGTHSQAEFPLRALQFKRGLLHEFRKGNSSKEQVRLHDLVQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKASQEIHFFDNDENYAKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLIIVREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCEVNTKYKAVRTSIYTKHLERWLKYFPIEQFHIVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLRFNIIFNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IA10</accession>
    <name>A0A3L7IA10_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Rpl22</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007651261.1">
        <property type="nucleotide sequence ID" value="XM_007653071.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254180.1">
        <property type="nucleotide sequence ID" value="XM_027398379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IA10"/>
    <dbReference type="SMR" id="A0A3L7IA10"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016562.1">
        <property type="protein sequence ID" value="ENSCGRP00001012329.1"/>
        <property type="gene ID" value="ENSCGRG00001013766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766349"/>
    <dbReference type="KEGG" id="cge:100766349"/>
    <dbReference type="CTD" id="6146"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046632">
        <property type="term" value="P:alpha-beta T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140236">
        <property type="term" value="P:translation at presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027254180.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14775" checksum="3F258CF27F8EE270" modified="2019-02-13" version="1">MAPMKKPVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IM84</accession>
    <name>A0A3L7IM84_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small ribosomal subunit protein eS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">40S ribosomal protein S10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Rps10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the small ribosomal subunit. The methylated form interacts with NPM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007644995.1">
        <property type="nucleotide sequence ID" value="XM_007646805.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244808.1">
        <property type="nucleotide sequence ID" value="XM_027389007.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IM84"/>
    <dbReference type="SMR" id="A0A3L7IM84"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023443.1">
        <property type="protein sequence ID" value="ENSCGRP00001019199.1"/>
        <property type="gene ID" value="ENSCGRG00001018710.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756654"/>
    <dbReference type="KEGG" id="cge:100756654"/>
    <dbReference type="CTD" id="6204"/>
    <dbReference type="GeneTree" id="ENSGT00440000034918"/>
    <dbReference type="OMA" id="YRRRDQE"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001335">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF10">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 21" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="17">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="90"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027244808.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18916" checksum="75B7005BA57AABA3" modified="2019-02-13" version="1">MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGPEGERPARFTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LNI6</accession>
    <name>A0A8C2LNI6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Semaphorin-3D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Sema3d</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307541.1">
        <property type="nucleotide sequence ID" value="XM_035451650.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314212.1">
        <property type="nucleotide sequence ID" value="XM_035458321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LNI6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009677.1">
        <property type="protein sequence ID" value="ENSCGRP00001006185.1"/>
        <property type="gene ID" value="ENSCGRG00001008283.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754027"/>
    <dbReference type="KEGG" id="cge:100754027"/>
    <dbReference type="CTD" id="223117"/>
    <dbReference type="GeneTree" id="ENSGT00940000156681"/>
    <dbReference type="OMA" id="KIYWPAT"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000026">
        <property type="term" value="P:regulation of multicellular organismal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05871">
        <property type="entry name" value="Ig_Sema3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11252">
        <property type="entry name" value="Sema_3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000015">
        <property type="entry name" value="Semaphorin 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000030">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000001">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042582">
        <property type="entry name" value="Sema3D_Sema"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF36">
        <property type="entry name" value="SEMAPHORIN-3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="13">
        <location>
            <begin position="44"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="611"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="742"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035307541.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="89647" checksum="97964D81C14FF561" modified="2022-01-19" version="1">MNANKDEKPRSRSQDLHLLHVWMMLIMSVLFLPVTETSKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHVFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHAYVCGTGAFHPLCGYIDLGVNKEELIFKLDMHSLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGLTHDHHYIRTDISEHYWLNGAKFIGTFPIPDTYNPDDDKIYFFFRESSQEGSTSDRSILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTHFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSRTYDPMIKSTRDFPDDVISFIRRHPVMYKSVYPVAGAPTFKRINVDYRLTQIAVDHVVAEDGQYDVMFLGTDIGTVLKVVSISKEKWNMEEVVLEELQVFKHPTAILNMELSLKQQQLYVGSWDGLVQLSLHRCDTYGKACADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVIFGIEFNSTFLECIPKSQQASVKWYIQRSGDEHREELKPDERIIKTDYGLLIRSLQKKDSGMYYCKAQEHTFIHTVVKLTLNVIENEQMENTQRAEHQEGQVKDLLAESRLRYKDYIQILSSPNFSLDQYCEQMWYREKRRQRNKGGPKWKHMQEIKKKRNRRHHRDLDELHRAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LP52</accession>
    <name>A0A8C2LP52_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Wdr41</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41. The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41. The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N-terminus). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N-terminus) and C9orf72 (via C-terminus). The C9orf72-SMCR8 complex associates with the ULK1/ATG1 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027401708.2"/>
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    <dbReference type="Ensembl" id="ENSCGRT00001009493.1">
        <property type="protein sequence ID" value="ENSCGRP00001006085.1"/>
        <property type="gene ID" value="ENSCGRG00001008129.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100761254"/>
    <dbReference type="CTD" id="55255"/>
    <dbReference type="OrthoDB" id="273067at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="WD repeat domain 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040102">
        <property type="entry name" value="WDR41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22805:SF2">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22805">
        <property type="entry name" value="WDR41-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25178">
        <property type="entry name" value="Beta-prop_WDR41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
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            <begin position="39"/>
            <end position="79"/>
        </location>
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            <begin position="80"/>
            <end position="128"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00070592"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006085.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027257509.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51345" checksum="325C50AAE992FF71" modified="2022-01-19" version="1">MLRWLIGGGREPQGLAEKAALQTIGEDQSQNPYTELLVLKAHRDIVRFLVQLDDNRFASAGDDGIIIVWNAQTGEKLLELRGHTQKITAVIAFPSLDSCEVDSQLILTASADRTVGVWDCDTGRQIQRVSCFQSTVKCLTVLQGLDIWLSGGNDLGVWNRKLDLLCKTDHLSDTGISALVEIPRNCVVAAVGKELIIFRLVAPTEGLLEWDIIEVKRLLDHQDNILSLVNINDKSFVTGSHVGELIIWDALDWTVQACERSFWNPSPQPDAQQEIKLCQKQNDISINHFTCDEENIFAAVGRGLYVYNLQLKHVIACQKTAHDSNVLHIDRLPNRQLISCSEDGSVRIWEVREKQQLAAEPVPTGFFNMWGFGRVNKQASQPVKKQQENGTTCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILWKNGEQESGFRSIKLFQKLEEDGDLHPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LP97</accession>
    <name>A0A8C2LP97_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100769884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_035450379.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035459146.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSCGRT00001010961.1">
        <property type="protein sequence ID" value="ENSCGRP00001006967.1"/>
        <property type="gene ID" value="ENSCGRG00001009442.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100769884"/>
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    <dbReference type="OrthoDB" id="9441928at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15947">
        <property type="entry name" value="7tmA_OR2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035306270.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34900" checksum="55E76E68FC88833A" modified="2022-01-19" version="1">MVNQSSPVGFLLLGFSEHPRLEKILFVVVLCSYLLTLLGNTLILLLSTLDPRLHSPMYFFLSNLSFLDLCFTTTCVPQMLVNLWGPTKTISFLGCSVQLFIFLSLGTTECILLTVMAFDRYVAVCQPLHYATIIHPRLCWQLAAVAWMMGLLQAIVQTPPTLRLPFCPHRQIDDFLCEVPSLIRLSCGDTTFNEIQLAVSSVILVVVPLSLILVSYGAIARAVLRINSAEAWKKALGTCSSHLIVVTLFYSSVIAVYLQPKNPYAQERGKFFGLFYAVGTPTLNPLIYTLRNKEVKRAFWRLLGRNGDSKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LQ48</accession>
    <name>A0A8C2LQ48_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">LOC100766450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007650384.1">
        <property type="nucleotide sequence ID" value="XM_007652194.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281945.1">
        <property type="nucleotide sequence ID" value="XM_027426144.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LQ48"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012097.1">
        <property type="protein sequence ID" value="ENSCGRP00001008002.1"/>
        <property type="gene ID" value="ENSCGRG00001010357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766450"/>
    <dbReference type="KEGG" id="cge:100766450"/>
    <dbReference type="OMA" id="CWACAFT"/>
    <dbReference type="OrthoDB" id="9565031at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000010">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 12 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027281945.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="34875" checksum="4EBB467C0C11C9BF" modified="2022-01-19" version="1">MQPKLRANGTTVTEFILLGLVEIPELWPVVFILFLLAYMTTVGGNLSILAAVLVESKLHTPMYFFLGNLSVMDVGCISVTIPSMLVRLLSHKRTIPYGDCLTQLFFFHLLAGVDCFLLTAMAYDRFLAICRPLTYSTRMNHIVQRILVATSWACAFSNALTHTVAISTLDFCGPNVINHFYCDLPQLFQLSCSSTQINELLLFAVGFIMAGTPMALIFISYIHVAAAVLRIRSAEGRKKAFSTCSSHLTVVAIFYGTGIFTYMRLGSIKLSDKDKAIGIFNTVINPMVNPLIYSLRNPDVQAALWRVISGRRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LVB2</accession>
    <name>A0A8C2LVB2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deaminated glutathione amidase</fullName>
            <ecNumber evidence="3">3.5.1.128</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nitrilase homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10 11" type="primary">Nit1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10 11">17A/GY</strain>
            <tissue evidence="10 11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.128" evidence="3"/>
    <dbReference type="RefSeq" id="XP_007645582.1">
        <property type="nucleotide sequence ID" value="XM_007647392.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007645583.1">
        <property type="nucleotide sequence ID" value="XM_007647393.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274793.1">
        <property type="nucleotide sequence ID" value="XM_027418992.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274794.1">
        <property type="nucleotide sequence ID" value="XM_027418993.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LVB2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012991.1">
        <property type="protein sequence ID" value="ENSCGRP00001008841.1"/>
        <property type="gene ID" value="ENSCGRG00001011024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766905"/>
    <dbReference type="KEGG" id="cge:100766905"/>
    <dbReference type="CTD" id="4817"/>
    <dbReference type="GeneTree" id="ENSGT00550000075099"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110050">
        <property type="term" value="F:deaminated glutathione amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000005">
        <property type="entry name" value="nitrilase homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027274793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027274794.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36150" checksum="A18F809C52ECB43A" modified="2022-01-19" version="1">MLGFITRPPRQLLSLLCTGNRLPRISVLCTQPRPRAMEVSSSTSWELPLVAVCQVTSTPNKQENFKTCAELVLEAARLGACLAFLPEAFDFIARNPAETLQLSEPLDGDLLGRYSQLARECGIWLSLGGFHERGQDWEQTQKIYNCHVLLNNKGLVVATYRKTHLCDVEIPGQGPMRESNSTMPGTILEPPISTPAGKVGLAICYDMRFPELSLKLAQAGAEILTYPSAFGSVTGPAHWEVLLRARAIESQCYVIAAAQCGRHHETRTSYGHSMVVDPWGTVVASCSEGPGLCLARIDLNFLQQIRQHLPVFQHRRPDLYGNLGQPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LWC7</accession>
    <name>A0A8C2LWC7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP synthase membrane subunit DAPIT, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">LOC113837449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035305508.1">
        <property type="nucleotide sequence ID" value="XM_035449617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LWC7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014875.1">
        <property type="protein sequence ID" value="ENSCGRP00001010651.1"/>
        <property type="gene ID" value="ENSCGRG00001012488.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113837449"/>
    <dbReference type="KEGG" id="cge:113837449"/>
    <dbReference type="GeneTree" id="ENSGT00390000015489"/>
    <dbReference type="OrthoDB" id="9435504at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009125">
        <property type="entry name" value="ATPMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34038">
        <property type="entry name" value="ATP SYNTHASE MEMBRANE SUBUNIT DAPIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34038:SF1">
        <property type="entry name" value="ATP SYNTHASE MEMBRANE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14960">
        <property type="entry name" value="ATP_synth_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01821">
        <property type="entry name" value="DAPIT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035305508.1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6252" checksum="5DABE943324F87C3" modified="2022-01-19" version="1">MAGAESDGQFQCTGIKKHFNSYTLTGRISCVLATYGGIALLVLYFKLRPKRTPAAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M0A2</accession>
    <name>A0A8C2M0A2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitogen-activated protein kinase 4</fullName>
            <ecNumber evidence="5">2.7.11.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Extracellular signal-regulated kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Mapk4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035294920.1">
        <property type="nucleotide sequence ID" value="XM_035439029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M0A2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015653.1">
        <property type="protein sequence ID" value="ENSCGRP00001011421.1"/>
        <property type="gene ID" value="ENSCGRG00001013070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771894"/>
    <dbReference type="KEGG" id="cge:100771894"/>
    <dbReference type="CTD" id="5596"/>
    <dbReference type="OrthoDB" id="8806754at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07854">
        <property type="entry name" value="STKc_MAPK4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000281">
        <property type="entry name" value="Mitogen-activated protein kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000136">
        <property type="entry name" value="mitogen-activated protein kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="368"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035294920.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="65597" checksum="B0A200AC37B98C4E" modified="2022-01-19" version="1">MAEKGDCIASVYGYDLGGRFIDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETDLARLLEQATLTEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILETIPVVREEDKEELLKVMPTFINSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAASQSQLSNWDRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSQSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAASTPPTAAVAADPMSCEDEPASLFLEIAQWVKSTQSGPDHASPTPDAPEHRLSASPPGHPTPVDGGASPQFDLDVFISRALKLCTKPEDLPENKLGDLNGACISEHPGDLVQTEAFSKERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M138</accession>
    <name>A0A8C2M138_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">A disintegrin and metallopeptidase domain 11</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="22">Disintegrin and metalloproteinase domain-containing protein 11 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Adam11</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283797.1">
        <property type="nucleotide sequence ID" value="XM_027427996.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M138"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015607.1">
        <property type="protein sequence ID" value="ENSCGRP00001011375.1"/>
        <property type="gene ID" value="ENSCGRG00001013003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764563"/>
    <dbReference type="KEGG" id="cge:100764563"/>
    <dbReference type="CTD" id="4185"/>
    <dbReference type="GeneTree" id="ENSGT00940000159790"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000147">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000014">
        <property type="entry name" value="disintegrin and metalloproteinase domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF114">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="22" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678705" evidence="15">
        <location>
            <begin position="25"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="18">
        <location>
            <begin position="243"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="17">
        <location>
            <begin position="448"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="677"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027283797.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="84754" checksum="9840B7E100DD193F" modified="2022-01-19" version="1">MRRLRRWAIAALLLLPLLPPPGLGALGPSGALHWRSSAQVGIPESPEGPEVTEPSRLVRESSGGEVRKHQVDTRVRQDPPRGTPVHLAQVSFVIPAFNTNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAGDHCYYHGRLRGNPHSLAALSTCQGLHGVFSDGNLTYIIEPKEMAGPWGPPQGPLPHLIYRTPLLPAPLGCREPGCLFAVPAQSAPPTWPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSRGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQALWGHGAADRFCYEKLNVEGTERGNCGRKGSGWVQCNKQDVLCGFLLCVNISGAPRLGDLGGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLGHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRYDPTQQGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M3F1</accession>
    <name>A0A8C2M3F1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myocyte enhancer factor 2D</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13 14 15">Myocyte-specific enhancer factor 2D isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13 14 15 16 17" type="primary">Mef2d</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14 15">17A/GY</strain>
            <tissue evidence="13 14 15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027248897.1">
        <property type="nucleotide sequence ID" value="XM_027393096.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307940.1">
        <property type="nucleotide sequence ID" value="XM_035452049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307941.1">
        <property type="nucleotide sequence ID" value="XM_035452050.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307942.1">
        <property type="nucleotide sequence ID" value="XM_035452051.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307943.1">
        <property type="nucleotide sequence ID" value="XM_035452052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M3F1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016447.1">
        <property type="protein sequence ID" value="ENSCGRP00001012214.1"/>
        <property type="gene ID" value="ENSCGRG00001013661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754401"/>
    <dbReference type="KEGG" id="cge:100754401"/>
    <dbReference type="CTD" id="4209"/>
    <dbReference type="GeneTree" id="ENSGT00940000159463"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF23">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027248897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035307940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035307941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035307942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035307943.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="54024" checksum="78E2315FED43C7BD" modified="2022-01-19" version="1">MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRASEELDGLFRRYGSSVPAPNFAMPVTVPVSNQSSMQFSNPSGSLVTPSLVTSSLTDPRLLSPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACPSPVGNGYVSARASPGLLPVANGNSLNKVIPAKSPPPPTHNTQLGAPSRKPDLRVITSQGGKGLMHHLNNAQRLGVSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLSSAELSSLPAFSSPAGLALGNVTAWQQPQQPQQPQQPQPPQSQPQPQPPQQPPQQQPHLVPVSLSNLIPGSPLPHVGAALTVTTHPHISIKSEPVSPSRERSPAPPPPAVFPAARPEPGEGLSSPAGGSYETGDRDDGRGDFGPTLGLLRPAPEPEADGSAVKRMRLDTWTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M456</accession>
    <name>A0A8C2M456_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Grik2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16 21">Postsynaptic cell membrane</location>
            <topology evidence="16 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258740.1">
        <property type="nucleotide sequence ID" value="XM_027402939.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M456"/>
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        <property type="protein sequence ID" value="ENSCGRP00001012726.1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M4Y7</accession>
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        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
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            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. ABHD16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003503187.1">
        <property type="nucleotide sequence ID" value="XM_003503139.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275794.1">
        <property type="nucleotide sequence ID" value="XM_027419993.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M4Y7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017615.1">
        <property type="protein sequence ID" value="ENSCGRP00001013378.1"/>
        <property type="gene ID" value="ENSCGRG00001014533.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762917"/>
    <dbReference type="KEGG" id="cge:100762917"/>
    <dbReference type="CTD" id="140701"/>
    <dbReference type="GeneTree" id="ENSGT00940000162803"/>
    <dbReference type="OMA" id="GHRALTC"/>
    <dbReference type="OrthoDB" id="6412627at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000074">
        <property type="entry name" value="Abhydrolase domain containing 16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF37">
        <property type="entry name" value="PROTEIN ABHD16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="174"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027275794.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53488" checksum="38DCFAE85CA92EF9" modified="2022-01-19" version="1">MCVICFMKALVHVFKIYLTANYTYNFRGWPVDFRWDDIHTTVSGSSSHRALTCAAAAAGVWLLHDAALGEDPLTRPPRGTRSQAQCLLQQIRELPSQLASYALAHSLGRWLVYPGSMFLMTRALLPLLQQGQERLVERYRGRRAKLVACDGNEIDTMFMDRRQHPGSHGRGLRLVICCEGNAGFYEMGCLSAPLEAGYSVLGWNHPGFGGSTGAPFPQHDANAMDVVVKYALHRLHFPPAHVVVYGWSIGGFTATWATMTYPELGALVLDATFDDLVPLALKVMPHSWKGLVVRTVREHFNLNVAEQLCCYPGPVLLLRRTQDDVVSTSSHIANLPSCQVEGDVEGNRGNELLLRLLQHRYPSVMAREGRTVVTRWLRTSNLAQEAAFYARYRVDDEWCLATLRSYRDHCQKEMDDAKTWGPHGLTFPWLVGQGLSPRRRRQLALFLARRHLKNLEATHCSPLEPEDFQLPWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M7W3</accession>
    <name>A0A8C2M7W3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">18S rRNA (guanine-N(7))-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bud site selection protein 23 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">rRNA methyltransferase and ribosome maturation factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Bud23</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54584"/>
            <dbReference type="Rhea" id="RHEA-COMP:13937"/>
            <dbReference type="Rhea" id="RHEA-COMP:13938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer with TRMT112; this heterodimerization is necessary for the metabolic stability and activity of the catalytic subunit BUD23. Interacts with GRIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003500970.1">
        <property type="nucleotide sequence ID" value="XM_003500922.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271962.1">
        <property type="nucleotide sequence ID" value="XM_027416161.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M7W3"/>
    <dbReference type="SMR" id="A0A8C2M7W3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019793.1">
        <property type="protein sequence ID" value="ENSCGRP00001015550.1"/>
        <property type="gene ID" value="ENSCGRG00001016132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755551"/>
    <dbReference type="KEGG" id="cge:100755551"/>
    <dbReference type="CTD" id="114049"/>
    <dbReference type="GeneTree" id="ENSGT00390000014737"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="16">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="17">
        <location>
            <begin position="204"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027271962.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31576" checksum="354E3C01F186A934" modified="2022-01-19" version="1">MASRSRRPEHSGPPELFYDQNEARKYVRNSRMIDIQTKMTERALELLCLPEGQPSFLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLLGDMGQGIPFRPGSFDGCISISAVQWLCNANKKSDVPARRLYCFFSSLYSALVHGARAVLQLYPENSEQLELITTQATRAGFTGGVVVDFPNSAKAKKFYLCLFSGPSTSLPKGLTESQDADQATELTFTSERAPHKKARRDLVKKSREWVLEKKERRRRQGKEVRPDTQYTGRKRKPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M936</accession>
    <name>A0A8C2M936_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Unconventional myosin-Va</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dilute myosin heavy chain, non-muscle</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Myo5a</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">May be a homodimer, which associates with multiple calmodulin or myosin light chains. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Interacts with MLPH. Interacts with SYTL4. Interacts with MYRIP. Interacts with RAB10; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles. Interacts with FMR1; this interaction occurs in association with polyribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027266949.1">
        <property type="nucleotide sequence ID" value="XM_027411148.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001020239.1">
        <property type="protein sequence ID" value="ENSCGRP00001015995.1"/>
        <property type="gene ID" value="ENSCGRG00001016350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753457"/>
    <dbReference type="KEGG" id="cge:100753457"/>
    <dbReference type="CTD" id="4644"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042641">
        <property type="term" value="C:actomyosin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043473">
        <property type="term" value="P:pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032252">
        <property type="term" value="P:secretory granule localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030050">
        <property type="term" value="P:vesicle transport along actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15478">
        <property type="entry name" value="Myo5a_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000002">
        <property type="entry name" value="Class V myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000006">
        <property type="entry name" value="Myosin VA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000089">
        <property type="entry name" value="Myosin VC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000003">
        <property type="entry name" value="Myosin-Va isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000001">
        <property type="entry name" value="unconventional myosin-Va"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058662">
        <property type="entry name" value="Myo5a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037988">
        <property type="entry name" value="Myo5a_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF273">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25966">
        <property type="entry name" value="Myo5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="23">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="22">
        <location>
            <begin position="69"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="21">
        <location>
            <begin position="1556"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1105"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="915"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1155"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1336"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1434"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1116"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="163"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027266949.1"/>
        </source>
    </evidence>
    <sequence length="1877" mass="218277" checksum="47AD08C012DA679F" modified="2022-01-19" version="1">MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGTDLEYRLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHEPLTIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDHVNQALHSAVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKAFIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQEEEKAISPTSATSSGRTPLTRVPVKPTKGRPGQMAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLGDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRRYKIRRAATIVVQSYLRGYLARNRYRKILREHKAVIIQKRVRGWLARTHYKRTMQAIIYLQCCFRRMMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLRNDVERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEERADKYKQETEQLVSNLKEENTLLKQEKETLNHLIVEQAKEMTETMERKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMLNVPKPGHKRTDSTHSSNESEYTFSSEFAETEDIVPRTEEPSEKKVPLDMSLFLKLQKRVTELEQEKQIMQDELDRKEEQVLRSKAKEEERPPIRGAELEYESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLILRSQLVSQKEAIQPKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSTMDYQELNEDGELWLVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSYRISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIPRKEKDFQGMLEYKREDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIVGAITLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMRLRDRKDSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLGFIARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MA82</accession>
    <name>A0A8C2MA82_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Hsbp1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003495173.1">
        <property type="nucleotide sequence ID" value="XM_003495125.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266573.1">
        <property type="nucleotide sequence ID" value="XM_027410772.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MA82"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020698.1">
        <property type="protein sequence ID" value="ENSCGRP00001016454.1"/>
        <property type="gene ID" value="ENSCGRG00001016781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751023"/>
    <dbReference type="KEGG" id="cge:100751023"/>
    <dbReference type="CTD" id="3281"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019896">
        <property type="term" value="P:axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF3">
        <property type="entry name" value="HEAT SHOCK FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027266573.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8559" checksum="3E86D8C3CDF87B56" modified="2022-01-19" version="1">MAETDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELEGENKIATAQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MG31</accession>
    <name>A0A8C2MG31_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Serine/arginine-rich splicing factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Splicing factor, arginine/serine-rich 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 31" type="primary">Srsf7</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6. Interacts with NXF1. Interacts with YTHDC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016833122.1">
        <property type="nucleotide sequence ID" value="XM_016977633.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281817.1">
        <property type="nucleotide sequence ID" value="XM_027426016.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MG31"/>
    <dbReference type="SMR" id="A0A8C2MG31"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022773.1">
        <property type="protein sequence ID" value="ENSCGRP00001018529.1"/>
        <property type="gene ID" value="ENSCGRG00001018245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758380"/>
    <dbReference type="KEGG" id="cge:100758380"/>
    <dbReference type="CTD" id="6432"/>
    <dbReference type="GeneTree" id="ENSGT00910000144115"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="14" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
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        <location>
            <begin position="123"/>
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            <begin position="123"/>
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            <begin position="194"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027281817.1"/>
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    </evidence>
    <sequence length="238" mass="27412" checksum="6948C44C62C2AAD9" modified="2022-01-19" version="1">MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSVSLRRSRSASLRRSRSGSIKGSRYFQSRSRSRSRSRSISRPRSSRSKSRSPSPKRSRSPSGSPRRSASPERMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MHH5</accession>
    <name>A0A8C2MHH5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial</fullName>
            <ecNumber evidence="4">1.3.1.124</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,4-dienoyl-CoA reductase [NADPH]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Decr1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2E,4E)-hexadienoyl-CoA + NADPH + H(+) = (3E)-hexenoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84788"/>
            <dbReference type="ChEBI" id="CHEBI:84790"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027259360.1">
        <property type="nucleotide sequence ID" value="XM_027403559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MHH5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023523.1">
        <property type="protein sequence ID" value="ENSCGRP00001019279.1"/>
        <property type="gene ID" value="ENSCGRG00001018780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753128"/>
    <dbReference type="KEGG" id="cge:100753128"/>
    <dbReference type="CTD" id="1666"/>
    <dbReference type="GeneTree" id="ENSGT00940000153801"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000288">
        <property type="entry name" value="2,4-dienoyl-CoA reductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF14">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027259360.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="36290" checksum="BB8A6FA94808E1AE" modified="2022-01-19" version="1">MAQLGRAFLARVSRLPCETGPLRFFSHGTKTLYQSIDAPQSKFFLPLLKPMLPPNTFQGKVAFVTGGGTGLGKAMTTFLSSLGAQCVIASRNIDVLKATAEEISSKTGNKVHAIRCDIRDPDMVHNTVLELIKVAGHPDVVINNAAGNFVSPSERLSPNAWKTITDIVLNGTAYVTLEIGKQLIKAQKGAAFLAITTVYAESGSGFVMPSSSAKSGVEAMNKSLAAEWGRYGMRFNIIQPGPIKTKGAFSRLDPTGRFEKEMIERIPCGRLGTMEELANLATFLCSDYASWINGAVIRFDGGEEVFLSGEFNSLKKVTKEEWDIMEGLIRKTKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQF6</accession>
    <name>A0A8C2MQF6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Voltage-dependent calcium channel gamma-3 subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Neuronal voltage-gated calcium channel gamma-3 subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Transmembrane AMPAR regulatory protein gamma-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Cacng3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with AP4M1 and GRIA1; associates GRIA1 with the adaptor protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511618.1">
        <property type="nucleotide sequence ID" value="XM_003511570.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266082.1">
        <property type="nucleotide sequence ID" value="XM_027410281.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MQF6"/>
    <dbReference type="SMR" id="A0A8C2MQF6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024916.1">
        <property type="protein sequence ID" value="ENSCGRP00001020672.1"/>
        <property type="gene ID" value="ENSCGRG00001019756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760631"/>
    <dbReference type="KEGG" id="cge:100760631"/>
    <dbReference type="CTD" id="10368"/>
    <dbReference type="GeneTree" id="ENSGT01050000244893"/>
    <dbReference type="OMA" id="YEQDTSE"/>
    <dbReference type="OrthoDB" id="9990458at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036477">
        <property type="term" value="C:somatodendritic compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099645">
        <property type="term" value="P:neurotransmitter receptor localization to postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000002">
        <property type="entry name" value="Voltage-dependent calcium channel gamma-2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008368">
        <property type="entry name" value="VDCC_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF5">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01792">
        <property type="entry name" value="VDCCGAMMA"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 19" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027266082.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35516" checksum="FB4EA036C494B6AD" modified="2022-01-19" version="1">MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHSVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRARSHSELLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKLTMGTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MWC6</accession>
    <name>A0A8C2MWC6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Low density lipoprotein receptor class A domain containing 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Low-density lipoprotein receptor class A domain-containing protein 4 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Ldlrad4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PMEPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258473.1">
        <property type="nucleotide sequence ID" value="XM_027402672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MWC6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027912.1">
        <property type="protein sequence ID" value="ENSCGRP00001023666.1"/>
        <property type="gene ID" value="ENSCGRG00001021830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758578"/>
    <dbReference type="KEGG" id="cge:100758578"/>
    <dbReference type="CTD" id="753"/>
    <dbReference type="GeneTree" id="ENSGT00390000000724"/>
    <dbReference type="OrthoDB" id="10038550at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070412">
        <property type="term" value="F:R-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060392">
        <property type="term" value="P:negative regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043445">
        <property type="entry name" value="TMEPAI/LRAD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16514">
        <property type="entry name" value="LOW DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16514:SF4">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027258473.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33856" checksum="76BD60830D93FE36" modified="2022-01-19" version="1">MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQVLIIVVVVTVMVVVVVCLLNHYKVSTRSFINRPNQSRRQEDGLQPEGCLWPSDSSVQRPGASEIMCAPRGRDRFTTPSFIQRDPFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTVFDSDLIDISMYNGGPCPPSSHSGISAATCSSNGRMEGPPPTYSEVMGHYPGTSFFHHQHSNAHRGSRPQFQPNNSEGTIVPIKGKDRKPGNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MXH9</accession>
    <name>A0A8C2MXH9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat domain 39C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 39C isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Ttc39c</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027260143.1">
        <property type="nucleotide sequence ID" value="XM_027404342.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314411.1">
        <property type="nucleotide sequence ID" value="XM_035458520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MXH9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028370.1">
        <property type="protein sequence ID" value="ENSCGRP00001024124.1"/>
        <property type="gene ID" value="ENSCGRG00001022129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754711"/>
    <dbReference type="KEGG" id="cge:100754711"/>
    <dbReference type="CTD" id="125488"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032474">
        <property type="term" value="P:otolith morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027260143.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="65667" checksum="486E3A088B937361" modified="2022-01-19" version="1">MAGSEQQRPRRRDEGEAAAAAAAAPLQDAELALAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCESEEAGVIETIKNKIKKSVDARKSAPSMVDRLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKAWKIYNKCYVDINALQELYQKKLTEEPLSSDAANDNHIVAEGVTEESLNRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLTYASESKDMKAPLATLALLWYHTVVRPFFALDGSDSKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLECQINSALTSFHTALELAIDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDMDGAQLVFKEVQKLFKRKNNQIEQFSVKKAERFRKQTPTRALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDPSVTGLKHLLLGAIHKCLGNSEDAVQFFQRAAKDELCRQNNLYVQPYACYELGCLLLGRPETVGRGRTLLLQAKEDFSGYDFENRLHVRIHAALASLRELVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N055</accession>
    <name>A0A8C2N055_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">3'-5' RNA helicase YTHDC2</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27 30" type="primary">Ythdc2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with MEIOC; binds transcripts that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally. Interacts (via ANK repeats) with XRN1. Interacts with ZCCHC4. Associates with the small ribosomal subunit. Interacts with RBM46.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027256650.1">
        <property type="nucleotide sequence ID" value="XM_027400849.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A8C2N055"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027205.1">
        <property type="protein sequence ID" value="ENSCGRP00001022960.1"/>
        <property type="gene ID" value="ENSCGRG00001021338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772467"/>
    <dbReference type="KEGG" id="cge:100772467"/>
    <dbReference type="CTD" id="64848"/>
    <dbReference type="GeneTree" id="ENSGT00940000155826"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051729">
        <property type="term" value="P:germline cell cycle switching, mitotic to meiotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0044829">
        <property type="term" value="P:host-mediated activation of viral genome replication"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0048599">
        <property type="term" value="P:oocyte development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070555">
        <property type="term" value="P:response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17987">
        <property type="entry name" value="DEXHc_YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06007">
        <property type="entry name" value="R3H_DEXH_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000008">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000004">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000005">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000284">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000811">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000492">
        <property type="entry name" value="YTH domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034083">
        <property type="entry name" value="R3H_DEXH_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 30" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="R3H" evidence="24">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="206"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="21">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="26">
        <location>
            <begin position="615"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="23">
        <location>
            <begin position="1291"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1167"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1194"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1234"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1253"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058947"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072066"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
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    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
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    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022960.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027256650.1"/>
        </source>
    </evidence>
    <sequence length="1433" mass="160299" checksum="DD59F8EAE8C74B12" modified="2022-01-19" version="1">MSRPSSVSPRPPAPGGGGTGGGGGPASCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVVLTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVVVFCGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSSADTEFADGSTTAERVLMKSPSPALHPPQKYKDRGILHPKRSTDDRSDQSSVKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPIRYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESSMVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQVGEQLLQLWERLPLGEKTPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N0H7</accession>
    <name>A0A8C2N0H7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDB1 and CUL4 associated factor 15</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">DDB1- and CUL4-associated factor 15 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Dcaf15</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027262000.1">
        <property type="nucleotide sequence ID" value="XM_027406199.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N0H7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030886.1">
        <property type="protein sequence ID" value="ENSCGRP00001026640.1"/>
        <property type="gene ID" value="ENSCGRG00001023898.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759899"/>
    <dbReference type="KEGG" id="cge:100759899"/>
    <dbReference type="CTD" id="90379"/>
    <dbReference type="GeneTree" id="ENSGT00390000011987"/>
    <dbReference type="OrthoDB" id="6354267at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20913">
        <property type="entry name" value="DCAF15-CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20917">
        <property type="entry name" value="DCAF15-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038914">
        <property type="entry name" value="DCAF15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047319">
        <property type="entry name" value="DCAF15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032734">
        <property type="entry name" value="DCAF15_WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541:SF1">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14939">
        <property type="entry name" value="DCAF15_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 15 WD40 repeat-containing" evidence="2">
        <location>
            <begin position="49"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027262000.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="66350" checksum="3307A528517CD29A" modified="2022-01-19" version="1">MAPSSKSERNSGAGSGGGGPGGAGGKRAAGRRREHVLKQLERVKISGQLSPRLFRKLPPRVCVSLKSIVDEDFLYAGHIFLGFSKCGRYVLSYTSSSGDDDFSFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSDLYLTVCEWPSDASKVIVFGFNTRSANGMLMNMMMMSDENHRDIYISTVAVPPRGRCAACQDASRAHPGDPSAQCLRHGFMLHTKYQVVYPFPTFQPAFQLKKDQVVLLNTSYSLVACAVSVHSAGDSSFCQILYDHTALPPAPPSSPGPWSPEAVPAFPSLGLEVVPARSSGAPEPSPAIAKAKEFVADIFRRAKEAKGGTLEEARLPSGLGPSSSRCRPSSESPAPSGEVAPRDSPPASGASAPEPGYINYTKLHYVLRSGEGTEPEDEFEDDKISLPFVVTDLRGRNLRPMRERTDMQGQYLTVEQLTLDFEYVINEVIRHDATWGHQFCSFSDYDIVILEVCPETNQVLINIGLLLLAFPAPTEEGQLRPKTYHTSLKVAWDLNTGIFETVSVGDLTEVKGQTSGSVWSSYRKSCVDMVMKWLVPESSGRYVNRMTNEALHKGCSLKVLADSERYTWIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N1L3</accession>
    <name>A0A8C2N1L3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LIM domain transcription factor LMO4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Breast tumor autoantigen</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">LIM domain only protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Lmo4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription cofactor. Plays a role in establishing motor neuron identity, in concert with MNX1, acting, at least in part, to disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron genes in motor neurons.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003514658.2">
        <property type="nucleotide sequence ID" value="XM_003514610.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251686.1">
        <property type="nucleotide sequence ID" value="XM_027395885.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N1L3"/>
    <dbReference type="SMR" id="A0A8C2N1L3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030085.1">
        <property type="protein sequence ID" value="ENSCGRP00001025839.1"/>
        <property type="gene ID" value="ENSCGRG00001023324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774445"/>
    <dbReference type="KEGG" id="cge:100774445"/>
    <dbReference type="CTD" id="8543"/>
    <dbReference type="GeneTree" id="ENSGT00940000157730"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050865">
        <property type="term" value="P:regulation of cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042659">
        <property type="term" value="P:regulation of cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021527">
        <property type="term" value="P:spinal cord association neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021520">
        <property type="term" value="P:spinal cord motor neuron cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021514">
        <property type="term" value="P:ventral spinal cord interneuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003281">
        <property type="term" value="P:ventricular septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09386">
        <property type="entry name" value="LIM1_LMO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09387">
        <property type="entry name" value="LIM2_LMO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000051">
        <property type="entry name" value="LIM domain transcription factor LMO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF5">
        <property type="entry name" value="LIM DOMAIN TRANSCRIPTION FACTOR LMO4"/>
        <property type="match status" value="1"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        <source>
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    <sequence length="165" mass="17994" checksum="C8AC295144AD7787" modified="2022-01-19" version="1">MVNPGSSSQPPPVTAGSLSWKRCAGCGGKIADRFLLYAMDSYWHSRCLKCSCCQAQLGDIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMRAQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLPDQKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N2M4</accession>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
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    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00940000158759"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N4H7</accession>
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    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003507631.1">
        <property type="nucleotide sequence ID" value="XM_003507583.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265240.1">
        <property type="nucleotide sequence ID" value="XM_027409439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N4H7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032568.1">
        <property type="protein sequence ID" value="ENSCGRP00001028320.1"/>
        <property type="gene ID" value="ENSCGRG00001025067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764579"/>
    <dbReference type="KEGG" id="cge:100764579"/>
    <dbReference type="CTD" id="56605"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030070">
        <property type="term" value="P:insulin processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF2">
        <property type="entry name" value="ERO1-LIKE PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679129" evidence="18">
        <location>
            <begin position="34"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="17">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="17">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001028320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027265240.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="53563" checksum="C7C08FB741E7778A" modified="2022-01-19" version="1">MSLGFRRAVSGQGAAVAVQLLVTLSFLPSLVKTQVTGVLDDCLCDIDSIDNFNNYKIFPKLKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGHSNKYLQAANNTKELEDCEQANKLGAINSTLSNESKEAFIDWARYDDSQDHFCELDDERSPAAQYVDLLLNPERYTGYKGSSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDDGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFKRRFDPVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNLEEDADTKTLLLSIFQDTKSFPMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEKEIQKLPENSPSKGFQLTRQEIVALLNAFGRLSTSIKELQNFKALLQHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N4R6</accession>
    <name>A0A8C2N4R6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Gtpbp8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003497903.2">
        <property type="nucleotide sequence ID" value="XM_003497855.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268417.1">
        <property type="nucleotide sequence ID" value="XM_027412616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N4R6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032511.1">
        <property type="protein sequence ID" value="ENSCGRP00001028263.1"/>
        <property type="gene ID" value="ENSCGRG00001025024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766372"/>
    <dbReference type="KEGG" id="cge:100766372"/>
    <dbReference type="CTD" id="29083"/>
    <dbReference type="GeneTree" id="ENSGT00390000001083"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000857">
        <property type="entry name" value="GTP-binding protein 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="110"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001028263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027268417.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32085" checksum="BC1EC22A4E4D6BC9" modified="2022-01-19" version="1">MAATGQWRRMGRLFEMAPALRRCPRVYSTSPAFAEVLRLPQKQLTKVLYPLRELAQHLVTDSGSGLIEQGLFDPSLEDIARAESIFEATARNRIEYLSSAVRLDHAPGLQQPEVCFIGRSNVGKSSLIKALFSMAPDVEVRISKKPGHTKKMNFFKVGKYFTLVDMPGYGYRAPEDFVDMVETYLKERKNLKRTFLLVDSVVGITKLDNIAVEMCEEFALPYVMVLTKIDKSSKGYLLKQVLQIQKFVNTQTQGCFPQLFPISAVTYSGVHLLKCFIADITGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QK15</accession>
    <name>A0A8C2QK15_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin Y-like 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Cyclin-Y-like protein 1 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Ccnyl1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin Y subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027252902.1">
        <property type="nucleotide sequence ID" value="XM_027397101.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QK15"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021672.1">
        <property type="protein sequence ID" value="ENSCGRP00001017428.1"/>
        <property type="gene ID" value="ENSCGRG00001017467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760997"/>
    <dbReference type="KEGG" id="cge:100760997"/>
    <dbReference type="CTD" id="151195"/>
    <dbReference type="GeneTree" id="ENSGT00940000154453"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000011">
        <property type="entry name" value="Cyclin-Y isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012399">
        <property type="entry name" value="Cyclin_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028934">
        <property type="entry name" value="Cyclin_CG14939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="196"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027252902.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41150" checksum="4869588427B34715" modified="2022-01-19" version="1">MGNTLTCCVSPNASPKLGRRAGPAEPDYESEIYEAAAGDAVAVAPAPAAAVEPAELDFGAGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTIKCVTLAIYYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKYKDLCRAAMRRSLSADNFIGIQRSNAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QMJ1</accession>
    <name>A0A8C2QMJ1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zinc finger protein 354A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Kidney, ischemia, and developmentally-regulated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Renal transcription factor Kid-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Transcription factor 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">LOC100759975</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016826577.1">
        <property type="nucleotide sequence ID" value="XM_016971088.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271108.1">
        <property type="nucleotide sequence ID" value="XM_027415307.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283418.1">
        <property type="nucleotide sequence ID" value="XM_027427617.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QMJ1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026841.1">
        <property type="protein sequence ID" value="ENSCGRP00001022596.1"/>
        <property type="gene ID" value="ENSCGRG00001021088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759975"/>
    <dbReference type="KEGG" id="cge:100759975"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000005">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000387">
        <property type="entry name" value="Zinc finger protein 354A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001586">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001004">
        <property type="entry name" value="Zinc finger protein 426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000011">
        <property type="entry name" value="zinc finger protein 615 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000416">
        <property type="entry name" value="zinc finger protein 879 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000485">
        <property type="entry name" value="Zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 20" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
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            <begin position="190"/>
            <end position="217"/>
        </location>
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            <end position="245"/>
        </location>
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        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071266"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077862"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00079003"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00080854"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022596.1"/>
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    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027283418.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="66809" checksum="43568B5F8DE30087" modified="2022-01-19" version="1">MAPEQREAKSRVSVTFEDVAVLFTRDEWKKLDHSQRSLYREVMLENYSNLASLAGFPFTKPKVISLLQQGEDPWKVEKEGPGGSPLGLKHNHRTTKSTQTQDSSFQELIVKNSKRNEPLNLKSEKLFIYEGKLEEKQDKNTLTIERSHKNNEFSPKSHREKRSSECEKQNTFKQIPYLSNQLKITPDKRYKCSMCEKTFTNTSSLRKHEKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYVCKECGKAFTLSTSLYKHLRTHTVEKSYRCKECGKSFGRRSGLFIHQKVHAGENPYKYNPGRKSSSCSTSLPGQRIHSRKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGERPYRCNECGKGFTSISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYRCQECDMSFGQSSALIQHRRIHTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKLFNHRSSLTNHYKIHVDEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F000</accession>
    <name>A0A9J7F000_CRIGR</name>
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        <submittedName>
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        <name evidence="5" type="primary">Tbc1d10a</name>
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    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Mammalia</taxon>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_035460195.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="159449at2759"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="111"/>
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        </location>
    </feature>
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            <begin position="429"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="PROSITE" id="PS50086"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F0I7</accession>
    <name>A0A9J7F0I7_CRIGR</name>
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        <recommendedName>
            <fullName evidence="14">Sulfotransferase</fullName>
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    </gene>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan. Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.</text>
            <dbReference type="EC" id="2.8.2.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chondroitin beta-D-glucuronate + n 3'-phosphoadenylyl sulfate = chondroitin 6'-sulfate + n adenosine 3',5'-bisphosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:11108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9827"/>
            <dbReference type="Rhea" id="RHEA-COMP:9828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57652"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:62065"/>
            <dbReference type="EC" id="2.8.2.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11109"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_027244034.1">
        <property type="nucleotide sequence ID" value="XM_027388233.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F0I7"/>
    <dbReference type="GeneID" id="100758880"/>
    <dbReference type="KEGG" id="cge:100758880"/>
    <dbReference type="CTD" id="9469"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008459">
        <property type="term" value="F:chondroitin 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045130">
        <property type="term" value="F:keratan sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000938">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF60">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="15">
        <location>
            <begin position="132"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027244034.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="54130" checksum="6B399D693A00AA99" modified="2023-06-28" version="1">MASPFPMDKGLTLPQDFVHSLKIRGKYALFLAFVVIVFVFIEKENKIISRVSDKLKQIPQVGTDANSTDPALLLSENASLLSLSELDSAFSQLQSRLYNLSLQLGVEPVMEAQGPEAAAEKPSQQAGAGHRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVSFHQGGASSAASALVYRDVLRQLLLCDLYVLEPFINPPPEDHLTQFLFRRGSSRSLCEDPVCTPFVKKVFEKYHCRNRRCGPLNVTLAAEACLRKDHVALKAVRIRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFAGKYESWKKWLAEGQDRLSEDEVQRLRGNCESIRLSAELGLRQPAWLRGRYMLVRYEDVARRPLQKAREMYSFAGIPLTPQVEDWIQKNTQAARDSSDIYSTQKNSSEQFEKWRFSMPFKLAQVVQAACGPAMHLFGYKLARDAASLTNRSISLLEERGTFWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F2T8</accession>
    <name>A0A9J7F2T8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gag-Pol polyprotein</fullName>
            <ecNumber evidence="8">2.7.7.49</ecNumber>
            <ecNumber evidence="7">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="39" type="primary">LOC113832706</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
            <tissue evidence="39">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Host cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="8"/>
    <dbReference type="EC" id="3.1.26.4" evidence="7"/>
    <dbReference type="RefSeq" id="XP_027246381.2">
        <property type="nucleotide sequence ID" value="XM_027390580.2"/>
    </dbReference>
    <dbReference type="GeneID" id="113832706"/>
    <dbReference type="KEGG" id="cge:113832706"/>
    <dbReference type="OrthoDB" id="9950135at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09273">
        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06095">
        <property type="entry name" value="RP_RTVL_H_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03715">
        <property type="entry name" value="RT_ZFREV_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.180">
        <property type="entry name" value="Gamma-retroviral matrix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000840">
        <property type="entry name" value="G_retro_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036946">
        <property type="entry name" value="G_retro_matrix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050462">
        <property type="entry name" value="Retroviral_Gag-Pol_poly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010999">
        <property type="entry name" value="Retrovr_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33166">
        <property type="entry name" value="GAG_P30 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01140">
        <property type="entry name" value="Gag_MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47836">
        <property type="entry name" value="Retroviral matrix proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="25" id="KW-0229">DNA integration</keyword>
    <keyword evidence="29" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="27" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="23" id="KW-1043">Host membrane</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="30" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="28" id="KW-0472">Membrane</keyword>
    <keyword evidence="19 31" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0519">Myristate</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="24" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="26" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0862">Zinc</keyword>
    <keyword evidence="19 31" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="33">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="34">
        <location>
            <begin position="532"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="35">
        <location>
            <begin position="709"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="36">
        <location>
            <begin position="1141"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="37">
        <location>
            <begin position="1404"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="409"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="32">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="RefSeq" id="XP_027246381.2"/>
        </source>
    </evidence>
    <sequence length="1701" mass="189430" checksum="C69A43080E5F45D1" modified="2023-06-28" version="1">MGQTMTTPLTLTLDHWTDVKTWAHNLSVEVRKGPWRTFCSSEWPSFGVGWPSGGTFNLSIISAVKRIIFQATGGHPNQVPYIIVWQDLVQNPPPWMKPWTSGIGTATVAVAAKPKSPPRIYPEINDVSLLDHPPPPYPQPIPHAAPQAPTDSQTASEIGPAAGTXSHRGRSPEGSGAGPDSTVALPLRAYGPAPAPGELVPLQYWPFSSADMYNWKTNHPSFSENPSGLTGLLESLMYSHQPTWDDCQQLLQVLFTTEERERILLEARKNVPGPDGTPTNLPNLIDAAFPLVRSDWDYNSAEGRGRLTVYHRALVAGLKGAIWRPTNLAKVREILQGPVEPPSVFLERLMEAYRRYTPFDPSSEGQQAAVAMAFIGQSASDIKKKLQRLEGIQDYTLQDLVKEAEKVYHKRETEEEKQERKKKEAEERENRRDRRQERNLAKILAAGVGGERSERGQSCYLGNRARRPPEDRTQLEKDQCAYCKEKGHWARDCPRKKQKGRKMLALEEDXGSWGSVPLPEPRVTLSVEGNPVNFLVDTGAENSVLTKPLGQLGSKRTLVIGATGSKLYPWTTERSLEIGKSQVTHSFLVIPECPVPLLGRDLLTKLKARVQFTPKGPEVTWGEAPITCLVLSLEEEYRLHEPKTGILPPKEWLTAFPEVWAEQTEMGLAKQAPPVVVELKEAATPVSVRQYPMTQGAKEGIRPHIQRLLQQGILIPCRSPWNTPLLPVCKPGTNDYRPVQDLSEVNKRVQDIHPTVPNPYNLLSSLPPERSWHTVLGLKDAFFCLRLHPNSQPLFAFEWQDPEGGHTGQLTWTRLPQGFKNSPTLFDEALHCDLAPFRARNPQISLLQYVDDLLLAALTQNXCLDRTRKLLKELGELGYRVSAKKAQLCRSEVTYLGYTLREGKWWLTEARKKTVRQIPTPTTPRQVHEFLGTAGFCRLWIPRFAMLAAPLYPLTKEKVPFTWTEEHQRVFDKIKTALLTAPALALPDLTKPFTLYVDERAGVARGVLTETLGPWKRPVAYLSKKLDPIASGWPSCLKPIAAVALLVKDTDKLTLGQHVTVITPHALESIVQQPPDRWMTNTRMTHYQSLLLNDRITFIPPAILNPATLLPEAEDSTPVHRCTDILAEETGTRKDLTDQSCPGVPNWYTDGSSFVVEGKRRVGAAVVDGKQVIWASSLPKGTSSQKAELLALTQALRLAEGKAINIYTDSRYAFTMAHIHGAIYRQRGLLTSAGRDVKNKEEILALLEAIHLPQKLAIVHCLGHQKGTDPVTKGNQMADLTAKQAAQGAVVLAEETGTPPEPPANYDLIEDMTRAGKARMFSFGGLAKTKDGRIILPSKEGQDYVRRIHQLTHLGNEKLKQLIKGSKYYVLGLNTIIKEVIESCQACTLTNAARSFKEPGKRMRGDRPGIYWEVDFTEIKPGKYGNKYLLVFIDTFSGWLEAFPTKFETAQMLTKKILEEILPRFGIPKVIGSDNGPAFVAQVSQELATQLGTNWKLHCAYRPQSSGQVERMNRTLKETLTKLAIETGGKDWVTLLPFVLFRVRNTPGRFSLTPYEILHGGPPPLTESGGILDPCTDSPSSSALFTHLKALEVVKTQIWDQIKEAYTPGTTSGSHGFQVGDSVLVRRHRAGTLEPRWKGPYLVLLTTPTAVKVDGIAAWIHASHIKKAPSQNENNRENNWTVAASDNPLKLRLCRIPNLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F3X6</accession>
    <name>A0A9J7F3X6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">NF-X1-type zinc finger protein NFXL1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">Nfxl1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13 14">17A/GY</strain>
            <tissue evidence="12 13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027246648.1">
        <property type="nucleotide sequence ID" value="XM_027390847.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246649.1">
        <property type="nucleotide sequence ID" value="XM_027390848.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246650.1">
        <property type="nucleotide sequence ID" value="XM_027390849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F3X6"/>
    <dbReference type="GeneID" id="100768316"/>
    <dbReference type="KEGG" id="cge:100768316"/>
    <dbReference type="CTD" id="152518"/>
    <dbReference type="OrthoDB" id="536399at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd16697">
        <property type="entry name" value="RING-CH-C4HC3_NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF1">
        <property type="entry name" value="NF-X1-TYPE ZINC FINGER PROTEIN NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="826"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027246648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027246649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027246650.1"/>
        </source>
    </evidence>
    <sequence length="914" mass="101251" checksum="53B13D4CDD8F786A" modified="2023-06-28" version="1">MDAWRQVAAGRGRARGRAAAVPSSGNGVPLGGAGGGRVKGSGNAVPSVPSPGGAATLAASGRRQRSTGGEAPQTPGASAELTSQRKFEEIKKANEAAARKLVEENCSSSSSEEEGDEDLEGKQGKIVANTFISYTTHTDGDIHELERTKQYLNEAFQAGAMTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQFLVSSVTDEDFGKKDYPWPCPKCRFEYKRSETPSRYYCYCGKVEDPPLDPWLVPHSCGQVCEREFKPPCGHKCLLLCHPGPCPPCPKMITTTCYCKKAKPIPRRCSAKQWSCQLPCGRKLLCGQHRCENPCHAGTCQPCPRVSRQKCVCGKKEAERSCASPVWHCDQVCGKTLPCGNHTCEQVCHVGACGACPRSGKRSCPCQKSKFSLPCTEDVPTCGDSCDKVLECGIHRCSQRCHRGPCETCRQEVEKQCRCGKHTKRMPCHKPYLCETKCIKMRDCQKHQCRRKCCPGNCLPCDQNCGRTLGCRNHKCPSVCHRGSCYPCPETVEVRCNCGNAKVTVPCGRERTTRPPKCKELCSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHSCPASCHDQALVKQTGRHQPIGPWEQPAEPAFIQTALPCPPCQVPIPVECLGKHEVSPLPCYAVGPYSCKRLCGRMLSCQNHTCMKECHQVTQVDGCTGKNKAGPECLQCEEGCSKPRPLGCPHPCVMPCHPGKCPPCVQMLRLKCHCKITSLYVECRKITTADINEKNLLSCCKNQCPKELPCGHRCKEVCHPGECPFNCNQKVKLRCPCKRIKRELPCNKIRENQVSVECDATCKEMKRKASEIKEAEANAALEEEKRRQQAELEAFENRLKGRRKKNKKRDEVAVELSVWQKYKSYLLPVFGVMVAVLVWYIAYGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F5K2</accession>
    <name>A0A9J7F5K2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding motif, single-stranded-interacting protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Rbms2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007644846.1">
        <property type="nucleotide sequence ID" value="XM_007646656.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248531.1">
        <property type="nucleotide sequence ID" value="XM_027392730.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F5K2"/>
    <dbReference type="GeneID" id="100763596"/>
    <dbReference type="KEGG" id="cge:100763596"/>
    <dbReference type="CTD" id="5939"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12471">
        <property type="entry name" value="RRM1_MSSP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12474">
        <property type="entry name" value="RRM2_MSSP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000014">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027248531.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="46759" checksum="89817DC3D2AAC0E2" modified="2023-06-28" version="1">MLLSVTSRPGISTFGYNKNNKKPYVSLSQQMAPPSPRNSTPNSSSGSNGHDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVTAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNGDMGGMALTYDPTTALPNGFYPTPYNIAHSRVLAQAALSPYLPSPVSSYQRLTQPSLQVPSPSWMQHQSYLMQPSVSVQKWADKETTGCKEKPRALMTGYVGGSVLTPGMDHPLSLQPASMMGPLTQQLGHLSLNSLGTFMPTAAAIQGAYIPQYPPGPSSNVSVEESSGQQNQVAVETPSDHGVYPFQFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F6M3</accession>
    <name>A0A9J7F6M3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Collagen alpha-1(IX) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Col9a1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structural component of hyaline cartilage and vitreous of the eye.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotrimer of an alpha 1(IX), an alpha 2(IX) and an alpha 3(IX) chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027248573.1">
        <property type="nucleotide sequence ID" value="XM_027392772.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F6M3"/>
    <dbReference type="GeneID" id="100755811"/>
    <dbReference type="KEGG" id="cge:100755811"/>
    <dbReference type="CTD" id="1297"/>
    <dbReference type="OrthoDB" id="6161718at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000105">
        <property type="entry name" value="Collagen type IX alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039947830" description="Collagen alpha-1(IX) chain" evidence="14">
        <location>
            <begin position="24"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="15">
        <location>
            <begin position="48"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="250"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="783"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027248573.1"/>
        </source>
    </evidence>
    <sequence length="920" mass="91785" checksum="C6801EC335F732E3" modified="2023-06-28" version="1">MKKFWEIPVFFFACSCLGPWVSATPKRRPRFPASPNGGSELCPKIRIGQDDLPGFDLISQFQIERTASRRTVQRVVGSTALQVAYKLGSNVDFRIPTRHLYPSGLPEEYSFLTTFRMTGSTLEKNWNIWQIQDSSGKEQVGVKINGQTKSVAFSYKGVDGSLQSAGFSNSPSLFDSQWHKIMIGVERTSATLYIDCVRIESLPIKPRGQVDTDGFAVLGKLVDNPRVSVPFELQWMVIHCDPLRPRRETCHELPVRSTPSQTTDDERGPPGEQGPPGPPGPPGVPGIDGIDGDRGPKGPVGPPGPPGEPGKPGAPGKPGTPGADGLTGPDGSPGSIGPRGQKGEPGVPGSRGFPGRGIPGPPGPPGTTGLPGELGRVGPSGDPGKRGPPGPPGPPGPSGTIGFHDGDPLCPNSCPPGRSGYPGLPGMRGHKGAKGEIGEPGRQGHKGEEGDQGELGEVGAQGPPGAQGLRGITGIVGDKGEKGARGLDGEPGPQGIPGAAGDQGQRGPPGEAGPKGDRGAQGSRGIPGSPGPKGDTGLPGVDGRDGIPGMPGTKGEAGKPGPPGDVGSQGLPGVPGIPGAKGVAGEKGNTGAPGKPGQLGSSGKPGQQGPPGEVGPRGPRGLTGSRGEAGPEGSPGIPGKLGPLGSPGLPGLPGPPGLPGMKGDRGVFGEPGPKGEQGASGEEGEAGARGDLGDIGLPGPKGSVGNPGEPGLRGPEGVRGLPGMEGPRGPPGPRGVQGEQGATGLPGIQGPPGRAPTDQHIKQVCMRVMQEHFAEMAASLKRPDVGASGLPGRPGPPGPPGPPGEHGFPGQMGLRGLPGIKGPPGALGLRGPKGDLGEKGERGPPGRGPKGLPGAIGLPGDPGPASYGKNGRDGEQGPPGVAGIPGVPGPPGPPGPPGFCEPASCTLQSGQRAFSKGPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FK45</accession>
    <name>A0A9J7FK45_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gag-Pol polyprotein</fullName>
            <ecNumber evidence="8">2.7.7.49</ecNumber>
            <ecNumber evidence="7">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="38" type="primary">LOC113834687</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="37" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
            <tissue evidence="38">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Host cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="8"/>
    <dbReference type="EC" id="3.1.26.4" evidence="7"/>
    <dbReference type="RefSeq" id="XP_027261909.1">
        <property type="nucleotide sequence ID" value="XM_027406108.2"/>
    </dbReference>
    <dbReference type="GeneID" id="113834687"/>
    <dbReference type="KEGG" id="cge:113834687"/>
    <dbReference type="OrthoDB" id="9893755at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09273">
        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06095">
        <property type="entry name" value="RP_RTVL_H_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03715">
        <property type="entry name" value="RT_ZFREV_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.180">
        <property type="entry name" value="Gamma-retroviral matrix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000840">
        <property type="entry name" value="G_retro_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036946">
        <property type="entry name" value="G_retro_matrix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050462">
        <property type="entry name" value="Retroviral_Gag-Pol_poly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010999">
        <property type="entry name" value="Retrovr_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33166">
        <property type="entry name" value="GAG_P30 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01140">
        <property type="entry name" value="Gag_MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47836">
        <property type="entry name" value="Retroviral matrix proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="28" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="26" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="23" id="KW-1043">Host membrane</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="29" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="27" id="KW-0472">Membrane</keyword>
    <keyword evidence="19 30" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0519">Myristate</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="24" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="25" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0862">Zinc</keyword>
    <keyword evidence="19 30" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="32">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="33">
        <location>
            <begin position="540"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="34">
        <location>
            <begin position="717"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="35">
        <location>
            <begin position="1149"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="36">
        <location>
            <begin position="1425"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="31">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="31">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="RefSeq" id="XP_027261909.1"/>
        </source>
    </evidence>
    <sequence length="1722" mass="192360" checksum="D96014AE0FC30153" modified="2023-06-28" version="1">MGQTVTTPLTLTLDHWTDVKTRAHNLSVEVRKGPWWTFCSSEWPSFCVGWPSGGTFNLSIISAVKRIIFQAKGGHPDQVLYIIVWQDLVQNPPPWMKPWTLGIGTATVAMAARKVPPSDFPEPAPTAPPRIYPEIDDVSLLDHPPPPYPQPVPHAAPQAPTDSRTASEIGPAARTRSRRGRSPEGSGAGPDLPLRAYGPAPAPGELIPLQYWPFSSADMYNWXTNHPSFSENPSGLTGLLESLMYSHQPTWDDCQQLLQVLFTTEERERILLEARKNVPGPDGTPTNLPNLIDAAFPLVRPDWDYNSGEGRGRLTVYRQALVAGLKGAARRPTILAKVREILQGPVEPPSVFLERLMEAYRRYTPFDPSSEGQQAAVAMAFIAQLASDIKKKLQRLEGLQDYTLQDLVKEAEKVYHKRETEEEKQERKKKEAEERENRRDRCQERNLTKILAAVVGGERSERGQSGYLGNRARRLPGGXRLQLEKDQCAYCKEKGHWARDCPRKKQKGPKMLALKEDXGSRGSFPLPEPRVALSVEGNPVNFLVDMGAEHSVLTKPLGQLGSKKTLVIGATGSKLYPWTTERSLEIGKSQVTHSFLVIPECPAPLLGRDLLTKLKAQVQFTPKGPQVTWGEAPITCLVLSLEEEYHLLEPKTGVLLPKEWLTAFPEVWAEQTEMGLAKQVPPMVVELKAAATPVSVRQYPMTQGAKEGIRPHIQRLLQQGILIPCWSPWNTPLLPVRKPGTNDYRPVQDLREVNKRVQDIHPTVPNPYNLLSSLPPERSWYTILDLKDAFFCLRLHLNSQPLFTFEWRDPEGGHTGQLTWTRLPQGFKNSPTLFDEXLHHDLAPFRARNPQISLLQYVDDLLLVASTQELCLDGTRKLLKELGELGYWVSAKKAQLCRSEVTYLGYTLREGKRWLTEARKKTVMQIPTPTTLRQVREFLGTXGFCRLWIPGFATLAAPLYPLTKEKVPFTWTEEHQRAFDKIKTSLLTAPXLTLPDLTKTFTLYVDERAVVARGVLTQTLGPWNRPVAYLSKKLDPVASRXPSCLKAIAXVALLVKDADKLTLGQHVTVITPHALESIVRQPPDRWMTNARMTHYQSLLLNDQITFAPPAILNPATLLPEAEDSTPVLRCIDVLDEETGTRKDLTDQPWPSVPNWYTDSSSFVVEGKRRAGAEVVDGKQVIWASSLPEGTSAQKAELLALTQALRLAEGKAINIYTDSRYAFATAHIHGAIYRQRGLLTSAGRDVKNKEEILALLEAIHLPQKLAIVHCLGHQKGTDQVTKGNQMADLTAKQAAQGAVVLGEETGTPPEPPQASFIHPSFIYPYKDYDLIEDMTRAGKAQMFSFGGLAKTKDGRIILPSKEGQDCVRRIHQLTHLGNKKLKQLIKGSKYYVLGLNTIIKEVIESCQACTLTNAARSFKEPGKRMRGDRPGIYWEVDFTEIKPGKYGNKYLLVFIDTFSGWVEAFPTKSETAQMVTKKILEEILPRFGIPKVIGSDNGPAFVAQVSQELATQLGTNWKLHCAYRPQSSGQAERMNRTLKETLTKLAIETGGKDWVTLLPFALLRVRNTPGRFGLTPYEILHGGLPPLTESGGILDPCTDSPSSSALFTHLKSLEVVKTQIWDQIKEAYTPGTTEVPHRFQVGDSVLVRRHRAGTLDPRWKGPYLVLLTTPTAVKVDRIAAWIHASHIKKVPSQNENNRENNWTVAASDNPLKLRLHRSPNLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FKH5</accession>
    <name>A0A9J7FKH5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Papss2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262199.1">
        <property type="nucleotide sequence ID" value="XM_027406398.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FKH5"/>
    <dbReference type="GeneID" id="100764888"/>
    <dbReference type="KEGG" id="cge:100764888"/>
    <dbReference type="CTD" id="9060"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000001">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000006">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF16">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="40"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="216"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="383"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027262199.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="69456" checksum="34D0C21946FDE36C" modified="2023-06-28" version="1">MSGVKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLICITSFISPFTKDRENARKIHELAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPECVLKTNLSSVSECVQQVVELLQEQNIVPHTTIKGIHELFVPENKVDQVRAEAESLPALSITKLDLQWVQVLSEGWATPLKGFMREKEYLQIIHFDTLLDDGVINMSVPIVLPVSVDDKVRLEGCSKFALMYEGRRVAILQDPEFYEHRKEERCSRVWGTATAKHPHIKMVMEGGDWLVGGDLQVLERIRWDDGMDQYRLTPLELKQKWKDMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLNWRMKQHAAVLEEGVLDPKSTVVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKTKKAMDFYDPARHDEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FML5</accession>
    <name>A0A9J7FML5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100754179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003513976.1">
        <property type="nucleotide sequence ID" value="XM_003513928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263775.1">
        <property type="nucleotide sequence ID" value="XM_027407974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FML5"/>
    <dbReference type="GeneID" id="100754179"/>
    <dbReference type="KEGG" id="cge:100754179"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15222">
        <property type="entry name" value="7tmA_OR51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000002">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF195">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027263775.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34789" checksum="04A9D0ECBE42A6F9" modified="2023-06-28" version="1">MPTSQNTTTSSIIFLLTGVPGLEAFHIWISIPFCFLYATALSGNSLILFAIITQPSLHEPMYYFLSMLSTTDLGLSISTLATMLGIFWFNAREISFNACLSQMFFIQLFTVMESSVLLAMAFDRYVAISNPLRYSSVLTDLKIVVIGVAIVARGTLIQTPLAVLLKRLSYCSSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALISTAGVDSVFIILSYVLIIRTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFVHRFGKGAPPYVHTLIANAYLLIPPVMNPIIYSVKTKQIRKAVLKVLRSSMAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FTX0</accession>
    <name>A0A9J7FTX0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Slc6a5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027266308.1">
        <property type="nucleotide sequence ID" value="XM_027410507.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FTX0"/>
    <dbReference type="GeneID" id="100761450"/>
    <dbReference type="KEGG" id="cge:100761450"/>
    <dbReference type="CTD" id="9152"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11499">
        <property type="entry name" value="SLC6sbd_GlyT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF241">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="502"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027266308.1"/>
        </source>
    </evidence>
    <sequence length="790" mass="87126" checksum="67DBC5DF4357E681" modified="2023-06-28" version="1">MNKQPANSLEAAVRGHRDSPRAPRTSPEQDLPAAAAATTAPPRVPRSASTGAQTFQSADARTYEAQQPGVRFCKLSSPRAQATSGALRDLSEGHSAQANPPSVAAGASNTLHCKIPALRGPEEDVNVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVVSDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FXG9</accession>
    <name>A0A9J7FXG9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Keratin-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100762761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with hair keratins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269103.1">
        <property type="nucleotide sequence ID" value="XM_027413302.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100762761"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007951">
        <property type="entry name" value="KRTAP_PMG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05287">
        <property type="entry name" value="PMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0416">Keratin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027269103.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18004" checksum="7BA5CA811CA1789B" modified="2023-06-28" version="1">MAYSCCSANFSSRSLRRCLPSSGSSCGSPYPSNLVYTTTTCSPTICQLGPSLNSGCQETCIEPISCQRSCVVSSPCQTACYYPRSSTPCSPCQGTYAGCLGFGSRSCRSLGYGSRSCYSVGCGPSGFRSLNCGVSGFPSVWYGPRFYYPAYLASTTFQPSCYRSVCGTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G1L8</accession>
    <name>A0A9J7G1L8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Band 4.1-like protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Erythrocyte membrane protein band 4.1-like 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">Epb41l5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16 17">17A/GY</strain>
            <tissue evidence="16 17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a complex composed of PALS1, CRB1 and EPB41L5. Within the complex, interacts (via FERM domain) with PALS1 (via HOOK domain) and with CRB1 (via intracellular domain). Interacts with CRB2 (via intracellular domain). Interacts with CRB3 (via intracellular domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027273606.1">
        <property type="nucleotide sequence ID" value="XM_027417805.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273607.1">
        <property type="nucleotide sequence ID" value="XM_027417806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G1L8"/>
    <dbReference type="GeneID" id="100757297"/>
    <dbReference type="KEGG" id="cge:100757297"/>
    <dbReference type="CTD" id="57669"/>
    <dbReference type="OrthoDB" id="6235974at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <location>
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            <begin position="582"/>
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            <begin position="585"/>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G2Q8</accession>
    <name>A0A9J7G2Q8_CRIGR</name>
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        </submittedName>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
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    <reference evidence="8" key="3">
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:vesicle-mediated transport"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="137"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027274611.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20172" checksum="14B9388DD2753519" modified="2023-06-28" version="1">MEAVVFLFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELTGHTIVTVLMLASLHWFIFLLNLPVATWNIYRFIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGFYLLCFFMYLYSFHYLSYSGFSSRPDGGFTELKQAMTLKWLQGGGGLGLKCSILSKRS</sequence>
</entry>
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    <accession>A0A9J7G443</accession>
    <name>A0A9J7G443_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEK6-subfamily protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">Nek7</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19">17A/GY</strain>
            <tissue evidence="18 19">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.34" evidence="13"/>
    <dbReference type="RefSeq" id="XP_007643379.1">
        <property type="nucleotide sequence ID" value="XM_007645189.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273258.1">
        <property type="nucleotide sequence ID" value="XM_027417457.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301569.1">
        <property type="nucleotide sequence ID" value="XM_035445678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G443"/>
    <dbReference type="GeneID" id="100765727"/>
    <dbReference type="KEGG" id="cge:100765727"/>
    <dbReference type="CTD" id="140609"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08224">
        <property type="entry name" value="STKc_Nek6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000204">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000240">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 18 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027273258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035301569.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36478" checksum="0D776D1B72D8CD0C" modified="2023-06-28" version="1">MDEQPQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYESPLKLLCAYISFTGSVLQMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVYDVAKRMHACTANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G488</accession>
    <name>A0A9J7G488_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Poly(RC)-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100768330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003500016.1">
        <property type="nucleotide sequence ID" value="XM_003499968.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276672.1">
        <property type="nucleotide sequence ID" value="XM_027420871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G488"/>
    <dbReference type="GeneID" id="100768330"/>
    <dbReference type="KEGG" id="cge:100768330"/>
    <dbReference type="OrthoDB" id="5799458at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22515">
        <property type="entry name" value="KH-I_PCBP1_2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22518">
        <property type="entry name" value="KH-I_PCBP1_2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000002">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000003">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="263"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027276672.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="34212" checksum="5286F1A255A92FAB" modified="2023-06-28" version="1">MDTGVIEGGLNATLTSRLLMHGKEVGSIIAKKGESVKKMREESGARTSISDGNCPERIITLAGPTNAIFKAFAMIIDKLEEGISSSMTNSTAASRPPVALRLVVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTEWAITIAGIPQSLIECVKQICVVMLETLSQPPHPHPKGLTITYRPKPSSSLVIFAGGQDRYSTGSDSASFPHTTQSMCLNPDLEGPPLELTKLHQLALQQSHFPMTHGNTGFSAGLDASAQTTSHELTISNDLIGCIIGRQGAKINEIRQMSGAQIKTANPVEGSTDRQVTITGSAASISLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G809</accession>
    <name>A0A9J7G809_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vomeronasal secretory protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC113836462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027278531.1">
        <property type="nucleotide sequence ID" value="XM_027422730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G809"/>
    <dbReference type="GeneID" id="113836462"/>
    <dbReference type="KEGG" id="cge:113836462"/>
    <dbReference type="OrthoDB" id="9621919at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002450">
        <property type="entry name" value="von_Ebner_gland"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF5">
        <property type="entry name" value="VOMERONASAL SECRETORY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01175">
        <property type="entry name" value="VNEBNERGLAND"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039953627" evidence="5">
        <location>
            <begin position="34"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="6">
        <location>
            <begin position="47"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027278531.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23329" checksum="462C4AC2E06E058F" modified="2023-06-28" version="1">MTDMDLSRRGQSLEMKSLLLTVTLFVLVAVLQAQDDLPFLSEDKNVSGTWYRKATVSNVNITESERPMEEFPFVMRTLEKGKIEITVTTMLNGECIQREFMMDKKKPGQYTAFWNMFLLYIYELPVMDHYIFYSEMKVLEQKVYVGELIGKDPTENHEALEDFKKFTERKGFPQENIIVPKQREMCVPVDDNDAPHSCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GA13</accession>
    <name>A0A9J7GA13_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Histone acetyltransferase</fullName>
            <ecNumber evidence="26">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">Kat7</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 26">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 26">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="26"/>
    <dbReference type="RefSeq" id="XP_007642669.1">
        <property type="nucleotide sequence ID" value="XM_007644479.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280081.1">
        <property type="nucleotide sequence ID" value="XM_027424280.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GA13"/>
    <dbReference type="GeneID" id="100757223"/>
    <dbReference type="CTD" id="11143"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902035">
        <property type="term" value="P:positive regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000092">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="22" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="23" id="KW-0137">Centromere</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21 26" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="28">
        <location>
            <begin position="343"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="24">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027280081.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="71688" checksum="4B47B280D66521C1" modified="2023-06-28" version="1">MAIGAKASWGDCFPFQRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLPSFGTEEPAYSTRRVTRSQQQPNPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADQDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQTPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GB46</accession>
    <name>A0A9J7GB46_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100773119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007639747.1">
        <property type="nucleotide sequence ID" value="XM_007641557.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280995.1">
        <property type="nucleotide sequence ID" value="XM_027425194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GB46"/>
    <dbReference type="GeneID" id="100773119"/>
    <dbReference type="KEGG" id="cge:100773119"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS3 C-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027280995.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12639" checksum="9FF835C236BB038E" modified="2023-06-28" version="1">MESGAEGCEVVVSGKLRGERAKSMKLVDGLMIHSGDPVNYYVDTAIRHVLLRQGVLGIKVKIMLPWDPSGKIGPKKPLPDHVSIMEPKDEILPTTPISQQKGGKPEPPAMPQPVPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GBX3</accession>
    <name>A0A9J7GBX3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein HID1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Hid1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003495714.1">
        <property type="nucleotide sequence ID" value="XM_003495666.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281523.1">
        <property type="nucleotide sequence ID" value="XM_027425722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GBX3"/>
    <dbReference type="GeneID" id="100772114"/>
    <dbReference type="KEGG" id="cge:100772114"/>
    <dbReference type="CTD" id="283987"/>
    <dbReference type="OMA" id="IFEDDKW"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027281523.1"/>
        </source>
    </evidence>
    <sequence length="788" mass="88538" checksum="B72B413C022B6A2C" modified="2023-06-28" version="1">MGSADSKLNFRKAVIQLTTKTQPVEATDDAFWDQFWADTATSVQDVFALVPAAEIRAVREESPSNLATLCYKAVEKLVQGAESGCHSEKERQVVLNCSRLLTRVLPYIFEDPDWRGFFWSTVPGAGRGGQGEEDDETARPLAESLLLAIADLLFCPDFTVQSHRRNNVDSAEDVRSLDSCEYIWEAGVGFAHSPQPNSIHDMNRMELLKLLLTCFSEAMYLPPSPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSATSTTCTVDGTTTGTAMDDAEPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLFFVLKSSDVLDILVPILYFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSVRVPMDIPVFTGTHADLLIVVFHKIVTSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLFSASQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRGVFHQLANLPTDPPSIHKALQRRRKTPEPLSRAGSQEGASMEGSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVSEDGTLRSLEPESQSSSAEGSPSEGEPSQTWREQRRLSSASASGQWNPTSDWILSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAVWFRTYMWGVIYLRNVDPPIWYDTDVKLFEIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GDJ4</accession>
    <name>A0A9J7GDJ4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Canalicular multispecific organic anion transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Abcc3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82961"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:60129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19121"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19122"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003501429.1">
        <property type="nucleotide sequence ID" value="XM_003501381.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280163.1">
        <property type="nucleotide sequence ID" value="XM_027424362.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100767558"/>
    <dbReference type="KEGG" id="cge:100767558"/>
    <dbReference type="CTD" id="8714"/>
    <dbReference type="OMA" id="KTWIMAF"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000007">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF405">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="961"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1096"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="311"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="626"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="967"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="1286"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="903"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027280163.1"/>
        </source>
    </evidence>
    <sequence length="1522" mass="169370" checksum="ED5830D21EBAFB9D" modified="2023-06-28" version="1">MDRLCGSGELGSKFWDSNLSVYTDTPDLTPCFQNSLLAWIPCIYLWAALPCYLFYLRNQQRGYIVLTRLSRLKTALGVLLWCVSWVDLFYAFHRLIYGSAPAPVFFITPLVVGITMLLGTLLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSATAEGKIADPLRFTTFYIYFALVLCSLILSCFKEKPPLFSPENVDPNPCPEASAGFLSRLSFWWFTKLAILGYRRPLEENDLWTLDEEDCSHKLVQRLLEAWQKQQKRASGPQTAAFEQKTPGEDEVLLRARPKSQKPSFLWALVRTFTSSLLMGVCFKLIQDLLSFINPQLLSILIRFISDPTAPTWWGFLLAGLMFVSSMMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSVLAGVAVIVLLIPLNGAVSMKMRTYQVQQMKFKDSRIKLMNEILNGIKVLKLYAWEPSFLEQVEGIRLSELQLLRKGAYLQAISTFIWVCTPFLVTLITLGVYVSVDENNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQDELDPQCVERETISPGYAITVHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGHVGCGKSSLVSALLGEMEKLEGAVCVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANVFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGHYSALLQHNGSFANFLRNYAPDEDQEGHEVFQDADEEVLLIEDTLSTHTDLTDNEPSMYEVRKQFMRQMSTMSSEGESQNRPVSKRHMNPSEKEMQVTKAKETGALIKDETAETGNVKMSVFWDYAKSVGLYTTLAICLLYAGQSAASIGANVWLSAWANDAVVNGRQNNTSQRLGVYATLGILQGLLVMLSAFTMVVGSVQAARLLHSALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLFNSFYTSISTLVVIVASTPLFIVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIEDFKVLSDKKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGEVGLSVSYALQITLALNWMIRMMSDLESNIIAVERVKEYSKTETEAPWVVEGSRAPEGWPTHGAVEFRNYSVRYRPGLELVLKNLTLRVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEICIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLHSFVSSQPAGLDFECSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFDDCTVLTIAHRLNTIMDYDRVLVLDKGVVAEFDSPTNLIAAGGIFYGMAKDAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GK35</accession>
    <name>A0A9J7GK35_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription cofactor vestigial-like protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Vgll1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a specific coactivator for the mammalian TEFs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the vestigial family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289230.1">
        <property type="nucleotide sequence ID" value="XM_027433429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GK35"/>
    <dbReference type="GeneID" id="100767081"/>
    <dbReference type="KEGG" id="cge:100767081"/>
    <dbReference type="CTD" id="51442"/>
    <dbReference type="OrthoDB" id="10069705at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF20">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027289230.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28398" checksum="D022597C550F3625" modified="2023-06-28" version="1">MDKIKKIGVQMPKSRQKPVKTEWNARCVIFSYFQGDISSVVDEHFSRALSNLKRSQRWSSLTHGENVILRNDSSMPPNQWRLTSSSTKPQPEASLVNGASSSNVDESGPEAIDQCPLSMPKTPSAHPQEMWQLSPLERQDFLEPTCSRALPDRHPAPEVYPDGRRGSLLALLQQDRYLNRPLEPATRENCNHAKIAGSTGLHMNLPPNSDHCKEMLTDTYKVIVVDNKKMDRHGSAGPSIDNETTVPDGRGFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GS73</accession>
    <name>A0A9J7GS73_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: C2 calcium-dependent domain-containing protein 6 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">C2cd6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035294725.1">
        <property type="nucleotide sequence ID" value="XM_035438834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759628"/>
    <dbReference type="KEGG" id="cge:100759628"/>
    <dbReference type="CTD" id="151254"/>
    <dbReference type="OrthoDB" id="2144823at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031462">
        <property type="entry name" value="CTSRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048363">
        <property type="entry name" value="CTSRT_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21665">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED TARGETING SUBUNIT TAU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21665:SF2">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED TARGETING SUBUNIT TAU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15729">
        <property type="entry name" value="CTSRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation channel sperm-associated targeting subunit tau C2" evidence="2">
        <location>
            <begin position="135"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2134"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035294725.1"/>
        </source>
    </evidence>
    <sequence length="2239" mass="251691" checksum="9633586DA4819139" modified="2023-06-28" version="1">MELPPPGNRRVSISNPQETPQKFSISSGMVRHRPSMVSAGTSRLSTLRPQSLQPNPILQRRSLSPSDAPMMRRGSNVSSVRYADEEGQTRSATEKDKEDKEKSKSTGTRLLNMLRKTLKGSQSEEMIVAQETPNLIPFGEVVGCLAVHIKSCRQFSHRFIVQQHVNLFIRISINHVVKYTKLRNLKSINNERNLVLRFDEVKYFSVQVPRRQDDERNNIFLELMQDGGDTGKPALSLGSVESHLYEVIQKGCFTEALQMKHRNSAICRLEVEFMFSYGAFGYGFSHQLKPLQKIIEPSMFMKIAPPPDRTDPATNVITPQQVEYPAFLSPDLNVSIGAPETSTNVVRLTKLHEKPRERLEKMKTEYRHLDTWIEKAEYLRNLITPKVAHKGSELVDKGDKESLVIPVLKVLDQDLSDPALYESAESIPEETLLPPIHTLLIKEDEAPPRLHVPLGREDRSIAFAPGEALIHKRPSIVRIVSSPQEDKQKKEKVPHFPYELVIPDKLTRQENTNQKGKTSNQLRTFWERQPTDIVGRLRKVAFAQNEYTTPIFRAEYTEFKPKHHFQKLSKGGPDPFLRNINSKMPFRKKNDQDVYIYPSTLSTEVAEHEDQDPPYPEHSRSAGSNTTWAEDPNLIAIHMVNKNNLPPDHITTTTMTSDRKNKSHAPTLNTTNTSNIKNIFASGTPVITITKISDSNSKLSTDPSFNTTKSSDTRRLSSGPSYHTTKLSDSKLSSGPTSDTTKPSDSRLSSGPSSHTTKLSDSKLSSGPNSHTTKLSDSRLSSGPSSHTTKPSDSKLSSGPSSDTTKPSDSRLSSGPSYHTTKLSDSKLSSGPSSDTTKPSDSRLSSGPSYHTTKLSDSRLSSGPSSDTTKPSDSRLSSGPSYHTTKLSDSKLSSGPSSDTTKPSDSRLSSGPSSHTTKPSDTRLSSGPSSHTTKPSDSRLSNGPSSHTTKPSDSRLSSGPSSDTTKPSDSRLSSGPSFHTTKASDTRLSSDMMLSSGPGSNSTQPSGTNRLSQNPSINGNKSSDLIKLSRDPSTISTKSSDPKKKLSHDPSITSTKSLDSKNKLSSSNRTVNSDLTNTANSPALRDTLALGPDLFTEDSSNMQSELEQLSNVSLPSYQRQSSMTRKVDIFHTLSSINFTSDIEHLKQSIVLKSILSKNLQHLSDELFSKSEVSTNTEPSGRMQDRVFEKVQDINSWFSPKDILNSQTLLSPVIKSVPQDLLPEGGPGTSSDIEHISDRLLEAVETHFPMNRKSSFKTKHLVSEVPASNPGSNGSACDCVVKQILSTPMLSQLETGMTPSEAQMALQDQLFTSWERCVSSQILNYGEKGKAVPLSHPKTGVSKIMQSFPVETLLENGIIKVIELDKENQSSLLNMQTASHKENLQNPTEQHSNVKNQTKLLARQNTPTSNPTDTFVCGADYTEDRQGMSAQESKYPTADKKSDLPNEHQSLDTEEAGPSSTSETLSSLLGRLKDPDKVMLKSCLKNIFNVFKSERKEHPEKEFDRLIQHSSPHGTEHLEKNQENFNKADKEDRKHILDPKLCVFLEKLSESEVKNMKSELGKHIQHYIIEKLSEAGHITKEDLTNIYQNLYQMNEKEEKEELKEQSPFQDKYSETVKEIMSFVNNFNHHFIDKHLEIKLRSFLNEILQNYFLKNLSENNLLNETDGVALCPSVPSLRNKSTQGSLHGLMQDISSGSFGSRLKINMNYPLNESLQNNLKVVSENELLSIKADLSEYFQVLFKDKLHKSELMTERQLKGINEQVNSITSPPTPLKHIKTDLSFRDESYFMREDLEEQIKYSKIGQNATLQIYLEEAELARKQEKGSAFSHNLKENPPTIWDHKHVYSREVKALNVIKVQSPNKNIKANLLNKSPERPSDLLLKKHKKDHGFMQLPQAENSVYKTETQEPYSWDGRSKTIQSKPFFEKTLKVRPLDKRENNNNCKLTAQEKPDTGFSPYLKLPTCKMSRENEHLNRLSFPTWRANTLIYVNPESGEQSKLDQYCQRWKGSNNNNKKHLVTFAQFKNEMENLYINPYEACNEKCAKISDSQSFKHKGNEKNSRPFFFPEVLKKENMKSTRKESDYAVKSKKSLHKIVRILPATLPPTRPHLRKSVPRTLLHWTARKTIHDCLDRYEDLQIPPVKPPKNSKSRARLLGKSPDDSNNRXKHCARPYTAPEPNKRRESIPGKFASPRMVSAGLVHIQIPTPEYEIRKIRSKRKLKENIEKRPLICERKGERKEKICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GV80</accession>
    <name>A0A9J7GV80_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin-related family member 4 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Cdhr4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
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                <person name="MacDonald M.L."/>
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                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
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                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
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            <strain evidence="13">17A/GY</strain>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="8" id="KW-1043">Host membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="50"/>
            <end position="69"/>
        </location>
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    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="375"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
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        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035299489.1"/>
        </source>
    </evidence>
    <sequence length="668" mass="74348" checksum="C3B920CDF874F140" modified="2023-06-28" version="1">MTGHFPSLFGEGPRLEGFAIFTGDEEGGPPSSTLSQFLLSTLCRNRAAKVCSVLFGLCLVAVICALLSLETMGQTVTTPLSLTLSHWKDVQEYAHNQSVNVRKRKWITLCSSEWPTFDVGWPRDGTFNPQTIFQIKEKIMDPGPHGHPDQVAYIVTWEALVQDPPPWVRPFLHPKGPSLLPPSNRSNRPIPSAPTPPTPLIPPNPPSHSNLYPTVVKDTKAKEKKTPKVLPPGEDQLVDLLMEEPPPYPPLPPPPEAEADSAAALAEAAPDPSPMAYRLRGRREQPVPDSTTLPLRTGLNGQPQYWPFSASDLYNWKNNNPSFSADPVRLTSLIESVLTTHQPTWDDCQQLLQVLLTSEEKQRVLLEARKNVPGVNGQPTQLPNEIDAACPLERPEWDFTTEADTFSGWVEAFPTKHETAKIVTKKLLEEIFPRYGMPQVLGTDNGPAFVSQVSQSVATLLGIDWKLHCAYRPQSSGQVERMNRTIKETLTKLSLATGTRDWVLLLPLALYRARNTPGPHGLTPFEILYGVPTPIINFLDQDVSDFANSPSLQAHLQALQLVQREVWKPLAQAYKDQRDHPTIPHSYQIGDTVWVRRHQAKNLEPRWKGPYIVLLTTPTALKVDGIAAWIHASHVKPARPTDSATASEWTAHRTQNPLKIRLSRTPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZG1</accession>
    <name>A0A9J7GZG1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Reticulon-4 receptor isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Rtn4r</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <topology evidence="4">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the Nogo receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300036.1">
        <property type="nucleotide sequence ID" value="XM_035444145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GZG1"/>
    <dbReference type="GeneID" id="100771485"/>
    <dbReference type="KEGG" id="cge:100771485"/>
    <dbReference type="CTD" id="65078"/>
    <dbReference type="OrthoDB" id="546383at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905573">
        <property type="term" value="F:ganglioside GM1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905576">
        <property type="term" value="F:ganglioside GT1b binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000018">
        <property type="entry name" value="Reticulon 4 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF174">
        <property type="entry name" value="RETICULON-4 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039934674" evidence="17">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="342"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035300036.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="50325" checksum="EF56F9D3B9C92330" modified="2023-06-28" version="1">MAAGSRLLAWVLWLQAWRVAAPCPGACVCYNEPKVTTSCPQQGLQAVPTGIPASSQRIFLHGNRISHVPAASFHSCRNLTILWLHSNALARIDATAFTGLTLLEQLDLSDNAQLRTVDPTTFHGLGHLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNNLQALPDNAFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFQDLGRLMTLYLFANNLSMLPAEALVPLRSLQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPPRLASHDLKRLAASDLEGCVVASGPFRPILTTQLTDEELLSLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPSSAEPPLTAVRPGGSESPGLPTTGPRRRPGCSRKNRTRSHCRLGQAGSGSSGAGEAEGSGALPALACSLAPVGLALILWTVLGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H1A3</accession>
    <name>A0A9J7H1A3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC113838236</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC118237702</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC118237702</name>
        <name evidence="14" type="synonym">LOC113838236</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15">17A/GY</strain>
            <tissue evidence="14 15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027289845.1">
        <property type="nucleotide sequence ID" value="XM_027434044.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301795.1">
        <property type="nucleotide sequence ID" value="XM_035445904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H1A3"/>
    <dbReference type="GeneID" id="118237702"/>
    <dbReference type="KEGG" id="cge:113838236"/>
    <dbReference type="KEGG" id="cge:118237702"/>
    <dbReference type="OrthoDB" id="9450483at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04981">
        <property type="entry name" value="IgV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001791">
        <property type="entry name" value="Ig gamma-2B chain C region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001142">
        <property type="entry name" value="Immunoglobulin heavy variable 5-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
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                <person name="MacDonald M.L."/>
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                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
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                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
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                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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                <person name="Lee K.H."/>
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        </source>
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    </evidence>
    <sequence length="295" mass="33637" checksum="5B16958CFBDF398C" modified="2023-06-28" version="1">MGCIQSITCKARIRRENIVVYDVCATIDQCPTRIEETSPIVLRYKTPYFKASARVVMPPIPRHETWVVGWIQACNQMEFFNTYSDLGMVFRVLCDFFIPLGCPAEAEEQPQVLNTTPKRFPGSSWELPDLREGRVKAISDSDGVSYPWYGNTTETVTLVGPTNKISRFSVSMNDNFYPSVTWAVPVSDSNVPLLTRIKRDQSFTTWLVAMNTTTKEKIILQTIKWRMRVDIEVDPLQLLGQRARLVGRTQQEQPRILSRMEPIPPNALVKPNANDAQVLMWRPKRGPPLVVIPPK</sequence>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
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            <authorList>
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            <strain evidence="10">17A/GY</strain>
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        <subcellularLocation>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2H2</accession>
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        <name evidence="10" type="primary">Tac4</name>
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    <organism evidence="9 10">
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tachykinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303700.1">
        <property type="nucleotide sequence ID" value="XM_035447809.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312733.1">
        <property type="nucleotide sequence ID" value="XM_035456842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H2H2"/>
    <dbReference type="GeneID" id="100761569"/>
    <dbReference type="CTD" id="255061"/>
    <dbReference type="OrthoDB" id="9538060at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031835">
        <property type="term" value="F:substance P receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007217">
        <property type="term" value="P:tachykinin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013055">
        <property type="entry name" value="Tachy_Neuro_lke_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11250">
        <property type="entry name" value="TACHYKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11250:SF2">
        <property type="entry name" value="TACHYKININ-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00267">
        <property type="entry name" value="TACHYKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039921315" evidence="8">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035303700.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20582" checksum="DA86850074FF7963" modified="2023-06-28" version="1">MLPLLALLLLIGPSVCTTTGDREQLTLGTAAESWVTVNLKGIPVASIELQLQEMKRSRTRQFYGLMGKRLEGIRPIQPKARMGYQLGRIMQDLLGERGLFVEVLYLTSGSFLFPDGTLATGKKDRMNCFSLEIFSGNLQTGDTPPECRAWSSGHRRPSESKRESRLSPSPATCSSLPGHRRGWPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H3H0</accession>
    <name>A0A9J7H3H0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC118239146 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC118239146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035303490.1">
        <property type="nucleotide sequence ID" value="XM_035447599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H3H0"/>
    <dbReference type="GeneID" id="118239146"/>
    <dbReference type="KEGG" id="cge:118239146"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035303490.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22805" checksum="8E9EFA2046E9C565" modified="2023-06-28" version="1">MIPAGLGENKALGRDALGFSVGCTIHTTVTLPSCHRHLRQKKGLGRPRVVRMCLCLEFFEDQLHPNGISGKTSGFLCFCIQSVVMSNIMEIPGRSNSALPFPPSLKEEKGSALEPWLFVLRHFRNVHECAKAGFRRDIQVYTENNLRNTKDFLTYHIHRAWWRRWTSCSIMSGLMEVGGPTLNVGRTIDGQRPQTELKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4H3</accession>
    <name>A0A9J7H4H3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Slc6a13</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70687"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:70688"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71247"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hypotaurine(out) + chloride(out) + 2 Na(+)(out) = hypotaurine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71243"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:71244"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>taurine(out) + chloride(out) + 2 Na(+)(out) = taurine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71223"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71224"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304650.1">
        <property type="nucleotide sequence ID" value="XM_035448759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4H3"/>
    <dbReference type="GeneID" id="100752749"/>
    <dbReference type="KEGG" id="cge:100752749"/>
    <dbReference type="CTD" id="6540"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002981">
        <property type="entry name" value="Na/ntran_symport_GABA_GAT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF111">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01196">
        <property type="entry name" value="GAT2TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 19" id="KW-0769">Symport</keyword>
    <keyword evidence="6 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="418"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="448"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="389"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
            <position position="390"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00033998"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00034027"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049351"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035304650.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="68324" checksum="12899B002322F9ED" modified="2023-06-28" version="1">MDNRVSGTTSNGETKPVCPVMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRKICPIFEGIGYASQIIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKTNDSLNVTSENATSPVIEFWERRVLKLSDGIQHLGMLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLAVLLIRGVTLPGAAQGIQFYLYPDITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCVLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREILILIVSVISFLIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESFCVAWVYGASRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCMATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKIRTLKGPLRERLRQLVCPAEDLPQKNRPEPTAPATPMTSLLRLTELESNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H7K1</accession>
    <name>A0A9J7H7K1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100763726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.</text>
    </comment>
    <comment type="function">
        <text evidence="10">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304054.1">
        <property type="nucleotide sequence ID" value="XM_035448163.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311962.1">
        <property type="nucleotide sequence ID" value="XM_035456071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H7K1"/>
    <dbReference type="GeneID" id="100763726"/>
    <dbReference type="KEGG" id="cge:100763726"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035304054.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13410" checksum="CF0B9ED9D0308443" modified="2023-06-28" version="1">MGHETAVDLTRQDQEMFSGIAQFPKRLPKLPKVVVIKSRLPADESSQVVNVLRGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAKLVNVLQERVRELMDQNAFSLTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HF47</accession>
    <name>A0A9J7HF47_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carcinoembryonic antigen-related cell adhesion molecule 3-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100755643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the immunoglobulin superfamily. CEA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309634.1">
        <property type="nucleotide sequence ID" value="XM_035453743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HF47"/>
    <dbReference type="GeneID" id="100755643"/>
    <dbReference type="KEGG" id="cge:100755643"/>
    <dbReference type="OrthoDB" id="6353782at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05740">
        <property type="entry name" value="IgI_hCEACAM_2_4_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05774">
        <property type="entry name" value="IgV_CEACAM_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000340">
        <property type="entry name" value="Carcinoembryonic antigen-related cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000244">
        <property type="entry name" value="carcinoembryonic antigen-related cell adhesion molecule 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050831">
        <property type="entry name" value="CEA_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427:SF1">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="266"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035309634.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40028" checksum="9B882BEAAE6308DF" modified="2023-06-28" version="1">MADEYPCALRKQKLTLGLPCAVNTPWLSVPSLHCERSPISTQPTIELVPSRVAEGESVLLVVHNLPENLRAFFWYKRANVFKNLEIARHIIATNSTVLGPVHSGREIVYSNGSLLLHNVTWNDTGFYTLRTLSTDMNDELAHVKLQLDTCRLPPITAQFSIEAMPPNVVEGESALLLPRNIPKNLRAFSWYKGVIIVSRHEIAWKEIITKKTLLGPAHSGREIVYFNGTLVLQNTTQNDAGYYTLITLNAQLETQETHVYLHIYKPVTQPIIRVTSTTVTAQSSVVLTCLPGDTGVSIRWIFNNRSLQLTERMTLSPTKCQLSIDPVRIEDAGDYQCEVFNPVSSKTSLPVSLVVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J7L1</accession>
    <name>A0A9J7J7L1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-defensin 110-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC113832331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027243292.1">
        <property type="nucleotide sequence ID" value="XM_027387491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J7L1"/>
    <dbReference type="GeneID" id="113832331"/>
    <dbReference type="KEGG" id="cge:113832331"/>
    <dbReference type="OrthoDB" id="9827999at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_027243292.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9421" checksum="DAAF298AB5A85E67" modified="2023-06-28" version="1">MAICACKRRIVRRVRQSLRDCWPADLEKARSNTPPKYRLERCEKVRGMCKTYRDGDEYNYGYCIRWRNQCCKQTASHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JAX2</accession>
    <name>A0A9J7JAX2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Ano8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027250600.1">
        <property type="nucleotide sequence ID" value="XM_027394799.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JAX2"/>
    <dbReference type="GeneID" id="100751640"/>
    <dbReference type="KEGG" id="cge:100751640"/>
    <dbReference type="CTD" id="57719"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF51">
        <property type="entry name" value="ANOCTAMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="238"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="705"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1014"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="920"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="964"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027250600.1"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117525" checksum="9AC4180136C01AB9" modified="2023-06-28" version="1">MAEAASGAGGATLEGERGKRPPPEGEPAAAPASGVLDKLFGKRLLQAGRYLVSHKAWMKTVPTEDCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTATYESLLRGADELGLRKAVKAEFGGGTRSFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQAVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNVIWSTLFLEEWKRREAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQLLVSLPLCLACLVCVFVLMLGCFQLQELVLSVKGLPRLVRFLPKVMLALLVSVSAEGYKKLAVWLNDMENYRLESAYERHLIIKVVLFQFVNSYLSLFYIGFYLKDMDRLKEMLATLLITRQLLQNLREVLQPHLYRRLGRGELGLRAVGELARALLGLLNPLRPDPRRHLEAQADEGGAGSHKCLGGGCGAPEEEEETPMERRPAGEGGEVPDGPRGVKEEDEEDEEDEEDEEDYEDEGEEGGLLDCGLRLKKVSFAERGAGRRRPGPGSDGLLEEGSPTMVEKGLEPGVFTLAEEDDESEGPPGSPGPEPPTILLRRAGGEGRDQGPDGGRDPETGSSDTAGRQRRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPEAAIVSVVVLEHLALLVKYLIHAAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQQRFQQQQRRRGEEEGSGTRTAGAARDAGGGRARARPGSRPRGARRPRQGRERPRRPGALLPPGPVLRLKQIIPLQARPPTPSGCAPPPRSPADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFAAREPAANGAPGGGARAHRNAGDEPAAAEPEPRPEDAGHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JE78</accession>
    <name>A0A9J7JE78_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fucose mutarotase</fullName>
            <ecNumber evidence="3">5.1.3.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Fuom</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-L-fucose = beta-L-fucose</text>
            <dbReference type="Rhea" id="RHEA:25580"/>
            <dbReference type="ChEBI" id="CHEBI:42548"/>
            <dbReference type="ChEBI" id="CHEBI:42589"/>
            <dbReference type="EC" id="5.1.3.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.1.3.29" evidence="3"/>
    <dbReference type="RefSeq" id="XP_007650706.1">
        <property type="nucleotide sequence ID" value="XM_007652516.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264855.1">
        <property type="nucleotide sequence ID" value="XM_027409054.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JE78"/>
    <dbReference type="GeneID" id="100772971"/>
    <dbReference type="KEGG" id="cge:100772971"/>
    <dbReference type="CTD" id="282969"/>
    <dbReference type="OrthoDB" id="10011710at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036373">
        <property type="term" value="F:L-fucose mutarotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="entry name" value="RbsD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050443">
        <property type="entry name" value="RbsD/FucU_mutarotase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31690">
        <property type="entry name" value="FUCOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31690:SF4">
        <property type="entry name" value="FUCOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="RbsD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027264855.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19622" checksum="9A0A0FD857D101AC" modified="2023-06-28" version="1">MCDKFTGSTLAGQEPNHSHQLLAGPWLQRAQDNEMYAGCPKKEFVQALVKLSVLADANFPTSSICQCGPVEIRADGLDIPQILEAVLKLLPLDTYVESPAAVMELVPSDKERGLQTPIWNHYESLLLKADCKKALMKIERFEFYERAKKAFAVVATGEMALYGNIILKKGTLDLDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JGD8</accession>
    <name>A0A9J7JGD8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc knuckle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC103162633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM90 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258890.1">
        <property type="nucleotide sequence ID" value="XM_027403089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JGD8"/>
    <dbReference type="GeneID" id="103162633"/>
    <dbReference type="KEGG" id="cge:103162633"/>
    <dbReference type="OrthoDB" id="9623814at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039213">
        <property type="entry name" value="FAM90"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16035:SF14">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 90 MEMBER A11, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16035">
        <property type="entry name" value="PROTEIN FAM90A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc knuckle" evidence="3">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027258890.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39787" checksum="8381017F7633B586" modified="2023-06-28" version="1">MSLEKHTSFQGHRGLPSQRAQRKPKGPMAQKVPPEEENPRVKCRDCGAFGHTWKSRRCPIKHAYEITVPQAQQGRNEKENRDPGRPQTQENLCQVERDKRPIQGKGQRCDVQQKKAPLEKLPLMNPRTNQHVQLAHPKMPGVIAGNRKRALPDGLETREPPVKKSLGRQMCPGNPSTKRHAGSCILPSRQEECQRMPAPGVLKPAFKQDGRMAFSEDPRRQKLPCTSEHHPRDVPKRNGLGQVFHMESKGQAPRTDQARLPLTVALVSDRACTESQETSSNCVVGQSLRMIFTRIQGDCWTSRFVDGAPGLPIEKQIPPSKCPASQEKGDGALSQVPWSVLSEDLLVSSSSEDSDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JK56</accession>
    <name>A0A9J7JK56_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Synaptotagmin-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Synaptotagmin XII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Syt12</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Can also form heterodimers. Interacts with SYT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027264481.1">
        <property type="nucleotide sequence ID" value="XM_027408680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JK56"/>
    <dbReference type="GeneID" id="100760230"/>
    <dbReference type="KEGG" id="cge:100760230"/>
    <dbReference type="CTD" id="91683"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08406">
        <property type="entry name" value="C2B_Synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000080">
        <property type="entry name" value="Putative synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000129">
        <property type="entry name" value="Synaptotagmin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030537">
        <property type="entry name" value="Syt12_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="152"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="283"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027264481.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="46664" checksum="5C2A3819D41C34EA" modified="2023-06-28" version="1">MAVDVTEYHLSVIKSPAGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPNPSPFPNYDYRYLQQKYGEAYVEAKLKRVSQWNAQRTNPRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMDYDAGSHTLHVAVLQGKDLLEREEATFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSVPLDPTALQEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKVADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKATADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNLGHVIIGPAASGMGTTHWNQMLATLRRPVSMWHPVRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JLF2</accession>
    <name>A0A9J7JLF2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ral guanine nucleotide dissociation stimulator-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100751191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007648513.1">
        <property type="nucleotide sequence ID" value="XM_007650323.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269206.1">
        <property type="nucleotide sequence ID" value="XM_027413405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JLF2"/>
    <dbReference type="GeneID" id="100751191"/>
    <dbReference type="KEGG" id="cge:100751191"/>
    <dbReference type="OrthoDB" id="9624459at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46793:SF1">
        <property type="entry name" value="1700018F24RIK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46793">
        <property type="entry name" value="1700018F24RIK PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="2">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027269206.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32519" checksum="20BF5C987DF46F24" modified="2023-06-28" version="1">MFCCFQASDDDSGHQRAKRCVLGHLWRRWRKRKLSKSPRFNTRSPDYLENFISCIPTAIKNQDILEIYVFLAVYPKFATTWEVLDLIMEMYGSFQPDCVEDQETKTAIFSFLSMWVHTHPQDFCDYPDVATVKRLVDYIRLNVPSSDVTIQTEELLSVLEEQEFEKDEEASDCGLFREGTPEDPVLDISGMEETLSLREASVEGPQGDLKPQDDTKLIDLEDGEPDVAEVEPVQLLFSDQPLPTSADAEKPLDVAAYVPAVEQIFVLGVVQLGDPEPFFPLPEVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JQ23</accession>
    <name>A0A9J7JQ23_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">General transcription factor II-I repeat domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Gtf2ird1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the retinoblastoma protein (RB1) via its C-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027271921.1">
        <property type="nucleotide sequence ID" value="XM_027416120.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JQ23"/>
    <dbReference type="GeneID" id="100769489"/>
    <dbReference type="KEGG" id="cge:100769489"/>
    <dbReference type="CTD" id="9569"/>
    <dbReference type="OrthoDB" id="9876044at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1460.10:FF:000002">
        <property type="entry name" value="General transcription factor II-I isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1460.10:FF:000005">
        <property type="entry name" value="general transcription factor II-I repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1460.10:FF:000006">
        <property type="entry name" value="General transcription factor II-I repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1460.10:FF:000007">
        <property type="entry name" value="General transcription factor II-I repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1460.10:FF:000008">
        <property type="entry name" value="General transcription factor II-I repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1460.10">
        <property type="entry name" value="GTF2I-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004212">
        <property type="entry name" value="GTF2I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036647">
        <property type="entry name" value="GTF2I-like_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016659">
        <property type="entry name" value="TF_II-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46304">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46304:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02946">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016441">
        <property type="entry name" value="TF_II-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117773">
        <property type="entry name" value="GTF2I-like repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51139">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="955"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="993"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027271921.1"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120163" checksum="2B482A355A208388" modified="2023-06-28" version="1">MVSFFPPDTCWNRESRHPSYPHIPWRWRERRPTGLEPGRPGYSWANEVTMALLGKLCDIPTNGCGSERWNSFARKDELINSLVSALDSMCSALSKLNTEVACVAVHNESVFVMGTEKGRMFLNTRKELQSDFLRFCRGPLWKDPEAGHPKKVQRCEGGGRSIPRSSLEQCSDVYLLQKMVEEVFDVLYSEAMGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLRRPPDDGGRDSKALLEMNGISLLPKGSRDFGLYGQASKVTPQDLPPTATPSSMTNFLYSTSMPNHTIRELKQEAPTCPLTPSDLSLGWPMPEPQVPSAQDFSDCCGQKPAGPAGPLIQNVHASKRILFSIVHDKSEKWDVFIKEMEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDPMKLEPASPPEDTSTEVCRDTMLDLAGTAWSDKSSVSEDCGPGTSGELGMLRPIKIEPEELDIIQVTVPDPSPTSEEMADSLPGHLPSEDSGYGMEIPADKGPSEEPWQEEKPAEESPGDVIRPLRKQVEMLFNTKYAKAIGTSEPVKVPYSKFLMHPEELFVLGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKRPELLTDGVKEQVVDTAGISPLPLSGLPPRSHLRPQVLPPHVPSLPTPPPERDSWDRLVDETPKRQGLQENYDTRLSRIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVLIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVKGLPDDIPFRNPNTYDIHRLEKILKARENVRMVIINQLQPFAEVCNDAKVPGSSGGRHRRAPSIRPQQLFLPPAKDIPKRKRKRVSEGNSVSSSSSSSSSSSNPESVASTNQISLVVKSRRSELHPNSVWPLPLPRAGPPTAPGTGRHWALRGTQPASEVQAHALVLPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JSS8</accession>
    <name>A0A9J7JSS8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-coenzyme A thioesterase 5 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100753824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027274271.1">
        <property type="nucleotide sequence ID" value="XM_027418470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JSS8"/>
    <dbReference type="GeneID" id="100753824"/>
    <dbReference type="KEGG" id="cge:100753824"/>
    <dbReference type="OrthoDB" id="6347013at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2240:FF:000001">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000024">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF3">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="6">
        <location>
            <begin position="203"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027274271.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="46434" checksum="400D934C468A3EDA" modified="2023-06-28" version="1">MVPTVSLKPAGRSCWDEPLGISVHGLAPEQPVTLRAALRDEKGALFRAHARYRADDHGGLDLARAPALGGSFAGIEPMGLLWALEPERPLWRLIKRDVWTPFVVELEVLDGHEPDGGRLLARAVHERHFMAPGVRRVPVREGRVRATLFLPPGNGPFPGIIDLFGIGGGLPEYRASLLAGKGFAVMALAYYNYDDLPKDMDIIHLEYFEEAVNYLLSHPQVKGPGIGLLGISRGGELCLSMASFLKGITAAVIINGSLANVVGKLCYKDETLPPLRVNADRIRVTKDGLSDISDVLSCPIEGPDQKSIIPVERSDTTFLLLVGQDDRNWKSEFYANEISKRLEAHGKEKPQVICYPETGHYIEPPYFPWCKASLHAYFGKPVVFGGEPRAHAMAQVDAWQKLQTFFHKHLDGEVRTTLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JTI9</accession>
    <name>A0A9J7JTI9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short transient receptor potential channel 4-associated protein isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Trpc4ap</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027277173.1">
        <property type="nucleotide sequence ID" value="XM_027421372.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JTI9"/>
    <dbReference type="GeneID" id="100753499"/>
    <dbReference type="KEGG" id="cge:100753499"/>
    <dbReference type="CTD" id="26133"/>
    <dbReference type="OrthoDB" id="1866965at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022162">
        <property type="entry name" value="TRPC4AP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743:SF1">
        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN TCPC4AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12463">
        <property type="entry name" value="DUF3689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_027277173.1"/>
        </source>
    </evidence>
    <sequence length="797" mass="90559" checksum="955892A3B05F8BAB" modified="2023-06-28" version="1">MAAAPAAAGAGASRGRQSAATAAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKLSKWSGIPQLLLKLHATSHLHSDFIECQNILKEISPLLSMEAMAFVTEDRKLTQEATYPNTYIFDLFGGVDLLVEILMRPTISIRGQKLKMSDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLGPSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVASEESEHSQASTVSPPVGTSGDNALPHTSARTQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRCVTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K0Z9</accession>
    <name>A0A9J7K0Z9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 88B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Tmem88b</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM88 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295224.1">
        <property type="nucleotide sequence ID" value="XM_035439333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316731.1">
        <property type="nucleotide sequence ID" value="XM_035460840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K0Z9"/>
    <dbReference type="GeneID" id="100771424"/>
    <dbReference type="KEGG" id="cge:100771424"/>
    <dbReference type="CTD" id="643965"/>
    <dbReference type="OrthoDB" id="9948320at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033355">
        <property type="entry name" value="TMEM88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28628">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 88-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28628:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 88B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035295224.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19544" checksum="C58DD6B6B53D236A" modified="2023-06-28" version="1">MSDQQERETEEDEGSTSDTAPMIPRRGSTDYHVSVLVCPRWPMLVTQGLRTLLLPGRTLVGFLFHLLLPGTVFLLVLLPAAAIVYLGFLCHSRVHPAPGPRCRALLSDRGSATLIVFGFLSLPPLLVLASAARSLLVRRLRPMLQSPAGTPEPPCPPRCSEEGLAGDRPDEEKQLCAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K296</accession>
    <name>A0A9J7K296_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Thymidine phosphorylase</fullName>
            <shortName evidence="12">TP</shortName>
            <ecNumber evidence="3 12">2.4.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">TdRPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Tymp</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>thymidine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 12">Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_035296716.1">
        <property type="nucleotide sequence ID" value="XM_035440825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K296"/>
    <dbReference type="GeneID" id="100757152"/>
    <dbReference type="KEGG" id="cge:100757152"/>
    <dbReference type="CTD" id="1890"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000003">
        <property type="entry name" value="Pyrimidine-nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.10:FF:000011">
        <property type="entry name" value="Thymidine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.30:FF:000003">
        <property type="entry name" value="Thymidine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004490">
        <property type="entry name" value="PRK05820.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515:SF0">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyrimidine nucleoside phosphorylase C-terminal" evidence="14">
        <location>
            <begin position="381"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035296716.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="50183" checksum="49F7DCB3805B42AE" modified="2023-06-28" version="1">MAAPGLPPPSTPEAAGAVSGRVSREPKQLPELIRLKRDGGHLSEADIRDFVHAVMDGSAQDTQIGAMLMAIRLQGMDIEETSVLTQALADSGQQLEWPKAWHQKLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVTQSPEQILLLLEEVGCCIVSQSEKLVPADGILYAARDVTATVDSLPLITASILSKKVVEGLSTLVVDVKFGGAAVFPDQEQARELAKTLVSVGVGLGLRVAAALTAMDNPLGRSVGHTLEVEEALLCMDGAGPPDLRDLVIRLGGTILWLSGQAETQDQGAARVAAVLDDGSALRRFQLMLSAQGVDPGLARALCSGSPTQRRQLLPHAREQVELLAPADGTVEHVLALPLARVLHELGAGRSRAGQPITPGVGAELLVDVGQWLDRGTPWLRVHLDGPVLSCQQRRALQGALVLSNRAPFKAPSPFAELVLPPTFAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K356</accession>
    <name>A0A9J7K356_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sorbin and SH3 domain-containing protein 1 isoform X18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Sorbs1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035297747.1">
        <property type="nucleotide sequence ID" value="XM_035441856.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315488.1">
        <property type="nucleotide sequence ID" value="XM_035459597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K356"/>
    <dbReference type="GeneID" id="100755778"/>
    <dbReference type="CTD" id="10580"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031589">
        <property type="term" value="P:cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11919">
        <property type="entry name" value="SH3_Sorbs1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11922">
        <property type="entry name" value="SH3_Sorbs1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11916">
        <property type="entry name" value="SH3_Sorbs1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000001">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000003">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000004">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003127">
        <property type="entry name" value="SoHo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035606">
        <property type="entry name" value="SORBS1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035610">
        <property type="entry name" value="SORBS1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035611">
        <property type="entry name" value="SORBS1_SH3_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF64">
        <property type="entry name" value="SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02208">
        <property type="entry name" value="Sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00459">
        <property type="entry name" value="Sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50831">
        <property type="entry name" value="SOHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SoHo" evidence="14">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="702"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="776"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1153"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="853"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="978"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1023"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1111"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035297747.1"/>
        </source>
    </evidence>
    <sequence length="1214" mass="134194" checksum="ECD4BFBBB6194BD6" modified="2023-06-28" version="1">MSSECDVGSSKAVVNGLAPGSHGQDKGMDPTKICTGKGTVTLRASSSYRETPSSSPVSPQESPKHESKSDEWRLSSSADANGNAQPSPLAAKGYRSVHPSLSTDKPQDATSSPAPSEVIVVPLYLVNTDRGQEGTATTPASLGPLGCIHTIPATTPAASPLTFPTLDDFIPPHLQRRPHHSQPASACGSLPPASQRPPPSPPPPLVPPIPEDLHRALEPDLPGPVSSTGSPLINEVSSSHIETDSQAFLPTSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPASERRVGEQDSVPTPAELTSPSRTAERRAKDDSRRVVKSAQDLSNVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLHSPRYSFSEDTKSPLSVPRSKSEMNSIDGEKVVKRSATLPLPARSSSLKSSPERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLEKDLNFCQAELEADLEKVETVNKSPSANSPQSSAISPDVTSEPPGYIYSSNFHAVKRESDGTPGVHTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESAEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGLEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPCTYIELLPPAEKAQPRKLAPVQILEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVLKRPLVKNPVDYIDLPYSSSPSRSTTASPQCTSHSKLIMPAPSSLPHPRRALSPEMHAITSEWISLTVGVPGRRSLAMTPPLPPLPEASVYDTDRLALSARARPSLPLSLPYSSRSDHSTLRPVVSPLALPPPHRAYSLAPGAQAPLHINGDGSVHTHQDGFSQSPHGNSDRVISELSDAFSSQSKRQPWREDGPYERKAESEAGERCPGGPKISKKSCLRPSDVVRCLSSEQRLSEFHTPDDSQSFKPLGSPFPAREAGPPELHRGVEADRKAAQSGISQPSHHSLSAGPDLTESEKNYVQPQAQQRRVTPDRSQTSQDLCSYQALYSYVPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KE27</accession>
    <name>A0A9J7KE27_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Unconventional myosin-Ia</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Brush border myosin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Myosin I heavy chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Myo1a</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in directing the movement of organelles along actin filaments.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306793.1">
        <property type="nucleotide sequence ID" value="XM_035450902.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A9J7KE27"/>
    <dbReference type="GeneID" id="100752754"/>
    <dbReference type="KEGG" id="cge:100752754"/>
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    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="C:microvillus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000043">
        <property type="entry name" value="unconventional myosin-Ia isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
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    </dbReference>
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        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR13140">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF291">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00612">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 14" id="KW-0518">Myosin</keyword>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="19"/>
            <end position="765"/>
        </location>
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    <feature type="domain" description="TH1" evidence="16">
        <location>
            <begin position="929"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="14">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041221"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057482"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3H6V4</accession>
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    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23464"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:12575"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:132105"/>
            <dbReference type="EC" id="2.4.1.174"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus</location>
            <location evidence="1 13">Golgi stack membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JH000181">
        <property type="protein sequence ID" value="EGV97756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307689.1">
        <property type="nucleotide sequence ID" value="XM_035451798.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310074.1">
        <property type="nucleotide sequence ID" value="XM_035454183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H6V4"/>
    <dbReference type="STRING" id="10029.G3H6V4"/>
    <dbReference type="PaxDb" id="10029-XP_007607333.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010720.1">
        <property type="protein sequence ID" value="ENSCGRP00001006790.1"/>
        <property type="gene ID" value="ENSCGRG00001009227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754969"/>
    <dbReference type="KEGG" id="cge:100754969"/>
    <dbReference type="CTD" id="55790"/>
    <dbReference type="eggNOG" id="KOG3588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244968"/>
    <dbReference type="OMA" id="IVVYFGE"/>
    <dbReference type="OrthoDB" id="431432at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047237">
        <property type="term" value="F:glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046398">
        <property type="term" value="P:UDP-glucuronate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019276">
        <property type="term" value="P:UDP-N-acetylgalactosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000059">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF19">
        <property type="entry name" value="CHONDROITIN SULFATE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV97756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035307689.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="60767" checksum="00407FE6CD6FB9B6" modified="2011-11-16" version="1">MVRRGLLGWISRVVILLVLLCCAISVLYMLACTPKGDQEQLGLPWANGPTGKDGYQAVLQEREEQHRNYVNSLKRQIAQLKDELQARSEQLRSGLDQASDATGLRSGWDSAPKAQADLLAFLRGQVDKAEVHAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDELVEAIESALESLNSPVESSPHQRAYTAADFIEGIYRTERDKGTLYELTFKGDHKHEFQRLVLFRPFGPIMKVKEEKLNMANTLINIIVPLARRVDKFRHFMQNFREMCIQQDGRVHLTVVYFGKEEMNEVKGILENTSKAANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGIIYGHQDAVPPLEQQLVIKKETGFWRDFGFGMTCQYQSDFINIGGFDLDIKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKHCMDELTPEQYKMCMQSKAMNEASHGQLGMLVFRHEIEAHLRKQKQKAGSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3H9H0</accession>
    <name>G3H9H0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 9">40S ribosomal protein S3a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100769276</name>
        <name evidence="6" type="ORF">I79_007042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000229">
        <property type="protein sequence ID" value="EGW00221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297554.1">
        <property type="nucleotide sequence ID" value="XM_035441663.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310686.1">
        <property type="nucleotide sequence ID" value="XM_035454795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H9H0"/>
    <dbReference type="STRING" id="10029.G3H9H0"/>
    <dbReference type="GeneID" id="100769276"/>
    <dbReference type="KEGG" id="cge:100769276"/>
    <dbReference type="InParanoid" id="G3H9H0"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGW00221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035297554.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10784" checksum="478197DE7A24BE60" modified="2011-11-16" version="1">MVLGKNKRLTKDRNKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTKTQGTKIASDGLKGRVFEVSLADLQNDEIAFRKFKLITEDVQVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3HBX9</accession>
    <name>G3HBX9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 140 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">WD and tetratricopeptide repeats protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24 25" type="primary">Ift140</name>
        <name evidence="20" type="ORF">I79_007932</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24 25">17A/GY</strain>
            <tissue evidence="24 25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the IFT complex A (IFT-A). IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts (via C-terminal region) with IFT122 (via C-terminal region). Interacts with TTC25. Interacts with TTC21A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000273">
        <property type="protein sequence ID" value="EGW04417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003501531.1">
        <property type="nucleotide sequence ID" value="XM_003501483.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280817.1">
        <property type="nucleotide sequence ID" value="XM_027425016.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303497.1">
        <property type="nucleotide sequence ID" value="XM_035447606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311142.1">
        <property type="nucleotide sequence ID" value="XM_035455251.1"/>
    </dbReference>
    <dbReference type="STRING" id="10029.G3HBX9"/>
    <dbReference type="PaxDb" id="10029-XP_007606672.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025502.1">
        <property type="protein sequence ID" value="ENSCGRP00001021258.1"/>
        <property type="gene ID" value="ENSCGRG00001020155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774958"/>
    <dbReference type="KEGG" id="cge:100774958"/>
    <dbReference type="CTD" id="9742"/>
    <dbReference type="eggNOG" id="KOG3617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153417"/>
    <dbReference type="OMA" id="YAQFMES"/>
    <dbReference type="OrthoDB" id="10258787at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120199">
        <property type="term" value="C:cone photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990403">
        <property type="term" value="P:embryonic brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031076">
        <property type="term" value="P:embryonic camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048701">
        <property type="term" value="P:embryonic cranial skeleton morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021532">
        <property type="term" value="P:neural tube patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035845">
        <property type="term" value="P:photoreceptor cell outer segment organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008589">
        <property type="term" value="P:regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000675">
        <property type="entry name" value="Intraflagellar transport 140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000010">
        <property type="entry name" value="Intraflagellar transport 140 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000011">
        <property type="entry name" value="Intraflagellar transport protein 140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002476">
        <property type="entry name" value="Intraflagellar transport protein 140 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056155">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056156">
        <property type="entry name" value="TPR_IF140_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23385">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24760">
        <property type="entry name" value="TPR_IF140_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="20" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="16">
        <location>
            <begin position="2"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 second beta-propeller" evidence="17">
        <location>
            <begin position="415"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="19">
        <location>
            <begin position="786"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="IF140 C-terminal TPR" evidence="18">
        <location>
            <begin position="1280"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGW04417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027280817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035303497.1"/>
        </source>
    </evidence>
    <sequence length="1462" mass="166052" checksum="10B8730EC307E19B" modified="2011-11-16" version="1">MALYFDHRIKAPDVSRSPSHITWHPTHPFLAVASVSPSCGGNVDIYLEQGEPVPDTHIERSSRVTSLCWHPTRLILAVGWETGEVIMFNKQDKEQHTVPLPHTTDIVILSWSTSGSCLVSGDKLGVLLLWRLDQRGRVQGTPLLKHEYGKSLTHCIFRLPPPGEDLVQLAKAAVSGDEKALDMFNWRKSSFGSFLKTGSQEGLSFFVSLMDGTVHYVDEKGKTAQVASTDSSIQMLFYIEKREALVVVTQNLLLSLYVVTPEGEAEEVMKVKLSGKTGRRADITLIEGTLLVTAVGEPVLRFWDLERGENYILSPQEKFGFEKGENINCVCFCKTKGLLAAGTNKGRVALWKKVPNSLSGRGVEGKDMWALQTPTELEGNITQIKWGSRKNLLAVSSADSVSILSEQAMSSHFHQQVAAVQISPSLVNVSFLSTGSTHSLRTDMHISGVFATKDAVAVWNGKQVAVFEPSGSTLRNAGTFLCETSVLAMHEESIYTVEPNRIQVRTWQGTVKQLLLFSESEGSPCFLDVCGTFLVAGTDLAHFKSFDLSRREAKVHCSSKNLAHMIPDVGSIMSLRCNANGNKISILLNKVDNSPDSKIYIYDVEMDTVNVFNFKTGQIGQTQTLPFNEPEMNESHIFMHERLASYIPVNHFWDQSEPRLFVCEALQEASGAQPQGVDKQPHVEDTCHKEDVLILSFFASEEHGFLLHDCFPRPPIYQSLLGMEVPHYYFTKKPGEAEKEDRVDSGHYHIPQMVAKRPLRDFVGLEDCDKPTREAMLNFSFFVTIGDMDEAFKSIKLIKSETVWENMARMCVKTQRLDVAKVCLGNMGHARGARALREAEREPELEARVAMLAIQLGMLEEAEELYKKCKRYDLLNKLYQASDQWQKAVEVAEVHDRVHLRTTYYNYAKHLEASADCGLALSYYEKSDTHRFEVPRMLSEDLQSLELYINRMKDKTLWRWWAQYLESQAEMDTALRYYELAQDYFSLVRIHCFQGNIQKAAEIANETGDWAASYHLARQYESQDEVKQAVHFYTRAQAFNNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEKGEQMDRAVMLYHKAGHFSKALELAFTTQQFAALQLIAEDLDEKSDPALLSRCSDFCIEHRQFEKAVELLLAAKKYHEALQLCLEQNMTITEEMAEKMTVSKDSKDLSEESRRELLEQIANCCMRQGNYHLATKKYTQAGNKLKAMRALLKSGDTEKIVFFAGVSRQKEIYIMAANYLQSLDWRKEPEIMKNIISFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLSKAKAKSPLDQETKLAQLQSKMTLVKRFIQARRTYTEDPKESIRQCELLLEEPDLDSTIRIGDVYGFLVEHHVQMEEYQMAFKYLEEMRKRIPSANISYYVDQRTVDTVHQGLGLPPSRILPERVRHNSMEDHKDVYEEVMEEVENDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>G3HD76</accession>
    <name>G3HD76_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Homeobox A6</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15 19">Homeobox protein Hox-A6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Hoxa6</name>
        <name evidence="15" type="ORF">I79_008452</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000291">
        <property type="protein sequence ID" value="EGW08855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502048.1">
        <property type="nucleotide sequence ID" value="XM_003502000.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285437.1">
        <property type="nucleotide sequence ID" value="XM_027429636.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HD76"/>
    <dbReference type="STRING" id="10029.G3HD76"/>
    <dbReference type="PaxDb" id="10029-XP_007620623.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001004670.1">
        <property type="protein sequence ID" value="ENSCGRP00001003267.1"/>
        <property type="gene ID" value="ENSCGRG00001003922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764757"/>
    <dbReference type="KEGG" id="cge:100764757"/>
    <dbReference type="CTD" id="3203"/>
    <dbReference type="eggNOG" id="KOG0489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161585"/>
    <dbReference type="OMA" id="YSSPCFY"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000879">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF14">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="155"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGW08855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027285437.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26479" checksum="090A43C59CDD5FBF" modified="2011-11-16" version="1">MSSYFVNPTFPGSLPSGQDSFLGQLPLYPAGYDALRPFPASYGASSLPDKTYTSPCFYQQSNSVLACNRASYEYGASCFYSDKDLSGASPSGNSKQRGPGDYLHFSPEQQYKPDSSSVQGKVLHEEGTDRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSGEDSEAKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3HGZ5</accession>
    <name>G3HGZ5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 17 18">Glucocorticoid modulatory element-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 17 18" type="primary">Gmeb2</name>
        <name evidence="13" type="ORF">I79_009890</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
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            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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                <person name="Wang J."/>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="10">Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
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                <person name="Andersen M.R."/>
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                <person name="Passarelli B."/>
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                <person name="Betenbaugh M.J."/>
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        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
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                <person name="Andersen M.R."/>
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                <person name="Wang J."/>
                <person name="Gui Y."/>
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                <person name="Betenbaugh M.J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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                <consortium name="RefSeq"/>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
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    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="82"/>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3HJM5</accession>
    <name>G3HJM5_CRIGR</name>
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        <recommendedName>
            <fullName evidence="8">Gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="3">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Ggct</name>
        <name evidence="11" type="ORF">I79_010873</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20505"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:71304"/>
            <dbReference type="EC" id="4.3.2.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:20506"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="3"/>
    <dbReference type="EMBL" id="JH000434">
        <property type="protein sequence ID" value="EGW05200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003503976.1">
        <property type="nucleotide sequence ID" value="XM_003503928.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285480.1">
        <property type="nucleotide sequence ID" value="XM_027429679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HJM5"/>
    <dbReference type="SMR" id="G3HJM5"/>
    <dbReference type="STRING" id="10029.G3HJM5"/>
    <dbReference type="PaxDb" id="10029-XP_007635603.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001147.1">
        <property type="protein sequence ID" value="ENSCGRP00001001123.1"/>
        <property type="gene ID" value="ENSCGRG00001000866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774679"/>
    <dbReference type="KEGG" id="cge:100774679"/>
    <dbReference type="CTD" id="79017"/>
    <dbReference type="eggNOG" id="KOG4059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="APHDYVM"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000007">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW05200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027285480.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21398" checksum="AA02A4FE807C286D" modified="2011-11-16" version="1">MASSGCEDHAGQEGETFLYFAYGSNLLTERIHLRNPSAVFCCVARLQDFKLDFGNFQGKTSERWHGGIATIFQSPGDEVWGVVWKMNKSNLSSLDEQEGVKSGVYVVIEIKVSTQEGKEITCRSYLMTNYESAPPSPQYKKVICMGAKENGLPLEYQEKLKAIEPNDYKGKISDEMEEIIKKGESKLYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3HLF4</accession>
    <name>G3HLF4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">LOC100767185</name>
        <name evidence="14" type="ORF">I79_011542</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000490">
        <property type="protein sequence ID" value="EGW04586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504511.1">
        <property type="nucleotide sequence ID" value="XM_003504463.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279386.1">
        <property type="nucleotide sequence ID" value="XM_027423585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HLF4"/>
    <dbReference type="STRING" id="10029.G3HLF4"/>
    <dbReference type="PaxDb" id="10029-XP_007630313.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016279.1">
        <property type="protein sequence ID" value="ENSCGRP00001012046.1"/>
        <property type="gene ID" value="ENSCGRG00001013553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767185"/>
    <dbReference type="KEGG" id="cge:100767185"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9590981at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW04586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027279386.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34837" checksum="47A938C52E6E1F0B" modified="2011-11-16" version="1">MSCVRRNNQSSTSEFILLGLPIWPQHQDMYSALFLAMYLATVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDISFSSVTAPKMLMNMLTHTQSISYAGCVSQVYFFLFFGDLDSFLLTSMAYDRYVAICHPLHYTTIMSQNLCILLVVVSWVLSFVSALVHTLLLVRLSFCGDNTIPHFFCDLSALLKLSSSDTTINDLVIVTVGVVIITVPLICILVSYGHIGATILRTPSTKGICKALSTCGSHLCVVSLYYGAIIGLYFFPSSSNTNGKDVIVSVLYTVVTPMLNPFIYSLRNRDMKGALRNTLSRTVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3HV50</accession>
    <name>G3HV50_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Pfdn5</name>
        <name evidence="5" type="ORF">I79_014827</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000760">
        <property type="protein sequence ID" value="EGV95373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003507253.1">
        <property type="nucleotide sequence ID" value="XM_003507205.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252494.1">
        <property type="nucleotide sequence ID" value="XM_027396693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HV50"/>
    <dbReference type="SMR" id="G3HV50"/>
    <dbReference type="STRING" id="10029.G3HV50"/>
    <dbReference type="PaxDb" id="10029-XP_007637722.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020696.1">
        <property type="protein sequence ID" value="ENSCGRP00001016452.1"/>
        <property type="gene ID" value="ENSCGRG00001016773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768547"/>
    <dbReference type="KEGG" id="cge:100768547"/>
    <dbReference type="CTD" id="5204"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905907">
        <property type="term" value="P:negative regulation of amyloid fibril formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV95373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027252494.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17314" checksum="0DB54C2FB7FF2764" modified="2011-11-16" version="1">MAQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLNKSNEGKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPAVQEKHAMKQAVMETMSQKIQQLTALGATQATAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>G3HVN3</accession>
    <name>G3HVN3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RAF proto-oncogene serine/threonine-protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Proto-oncogene c-RAF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Raf-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 30" type="primary">Raf1</name>
        <name evidence="26" type="ORF">I79_015011</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="27" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JH000781">
        <property type="protein sequence ID" value="EGW12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003507391.1">
        <property type="nucleotide sequence ID" value="XM_003507343.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284970.1">
        <property type="nucleotide sequence ID" value="XM_027429169.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HVN3"/>
    <dbReference type="IntAct" id="G3HVN3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="10029.G3HVN3"/>
    <dbReference type="GlyGen" id="G3HVN3">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007621058.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025415.1">
        <property type="protein sequence ID" value="ENSCGRP00001021171.1"/>
        <property type="gene ID" value="ENSCGRG00001020096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769018"/>
    <dbReference type="KEGG" id="cge:100769018"/>
    <dbReference type="CTD" id="5894"/>
    <dbReference type="eggNOG" id="KOG0193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SAYKRHA"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="8" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="301"/>
        </location>
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        <location>
            <position position="375"/>
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        <ligand>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027284970.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="72894" checksum="E55EDD67B23E9C26" modified="2011-11-16" version="1">MEHIQGAWKSISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTVGDSGVPALPSLTMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3HZG3</accession>
    <name>G3HZG3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4 8 9">G patch domain and ankyrin repeat-containing protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein BAT4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">Gpank1</name>
        <name evidence="4" type="ORF">H671_1g2787</name>
        <name evidence="3" type="ORF">I79_016464</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CHO K1 cell line</strain>
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        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8 9">17A/GY</strain>
            <tissue evidence="8 9">Liver</tissue>
        </source>
    </reference>
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        <property type="entry name" value="GPANK1"/>
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        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
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        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
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            <end position="298"/>
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            <begin position="201"/>
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        <source>
            <dbReference type="EMBL" id="EGV95288.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ERE88834.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000030759"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CHO K1 cell line</strain>
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    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
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    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer; the dimers can form tetramers. Interacts with NALCN. Interacts with TMEM147.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EGV95582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003509406.5"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027405051.2"/>
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    <dbReference type="Ensembl" id="ENSCGRT00001012964.1">
        <property type="protein sequence ID" value="ENSCGRP00001008816.1"/>
        <property type="gene ID" value="ENSCGRG00001011017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753955"/>
    <dbReference type="KEGG" id="cge:100753955"/>
    <dbReference type="CTD" id="1131"/>
    <dbReference type="eggNOG" id="KOG4220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160084"/>
    <dbReference type="OMA" id="ISASWIH"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:basolateral plasma membrane"/>
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    <sequence length="589" mass="66140" checksum="F5FAD2BBF567BA1E" modified="2011-11-16" version="1">MTLHSNSTTSPLFPNISSSWVHSSSEAGLPLGTVTHLGSYNISQAAGNFSSNDTSSDPLGGHTVWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISIVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQSMKRSSRRKYGRCHFWFTTKSWKPSVEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNATKLPSSDNLQVPDEDLGTVDVERNANKLQAQKSMDDGDSCQKDFSKLPIQLESAVDTTKTSDTNSSVDKTTSTLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
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        <name evidence="7" type="ORF">I79_018678</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPOT14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGW00450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027407682.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297908.1">
        <property type="nucleotide sequence ID" value="XM_027442107.2"/>
    </dbReference>
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    <dbReference type="PaxDb" id="10029-XP_007612826.1"/>
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        <property type="protein sequence ID" value="ENSCGRP00001004713.1"/>
        <property type="gene ID" value="ENSCGRG00001006063.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100766732"/>
    <dbReference type="CTD" id="7069"/>
    <dbReference type="eggNOG" id="ENOG502S7IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044890"/>
    <dbReference type="OMA" id="FASLHHI"/>
    <dbReference type="OrthoDB" id="9450804at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140678">
        <property type="term" value="F:molecular function inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010866">
        <property type="term" value="P:regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053719">
        <property type="entry name" value="Lipogen_MT_Stabilize_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009786">
        <property type="entry name" value="Spot_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315">
        <property type="entry name" value="SPOT14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315:SF18">
        <property type="entry name" value="THYROID HORMONE-INDUCIBLE HEPATIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07084">
        <property type="entry name" value="Spot_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGW00450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027263483.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16997" checksum="44D61B346BA7CCFA" modified="2011-11-16" version="1">MQVLTKRYPKNCLLTVMDRYSAVVRNMEQVVMIPSLLRDVQLSGHGGSAQEGAPDLYTYFTMLKTICVEVEHGLLPREEWQAKVAGSEASDTENEAVEAEEAEDERVSGELDLEAQFHLHFSSLHHILTHLTHKAQEVTRKYQEMTGQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3I7Z1</accession>
    <name>G3I7Z1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Tfdp1</name>
        <name evidence="12" type="ORF">I79_019645</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001471">
        <property type="protein sequence ID" value="EGW14684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511220.1">
        <property type="nucleotide sequence ID" value="XM_003511172.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308296.1">
        <property type="nucleotide sequence ID" value="XM_035452405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I7Z1"/>
    <dbReference type="STRING" id="10029.G3I7Z1"/>
    <dbReference type="PaxDb" id="10029-XP_007630456.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031516.1">
        <property type="protein sequence ID" value="ENSCGRP00001027269.1"/>
        <property type="gene ID" value="ENSCGRG00001024323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774706"/>
    <dbReference type="CTD" id="7027"/>
    <dbReference type="eggNOG" id="KOG2829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154652"/>
    <dbReference type="OMA" id="MSPNDAH"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.80:FF:000001">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009404">
        <property type="entry name" value="Transcription_factor_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="11">
        <location>
            <begin position="111"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="10">
        <location>
            <begin position="200"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGW14684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035308296.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45227" checksum="E1501D0FAED165B8" modified="2011-11-16" version="1">MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGKQLLPKTFGQSNVNITQQVVIGTPQRPAASNTIVVGSPHTPNTHFVSQNQPSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGNCSAEDLKVARSLVPKALEPYVTEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGEDDDDDDDFNENDEED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-01-01" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>P14413</accession>
    <name>ATP6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase F(0) complex subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>F-ATPase protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Proton-conducting channel, ATP synthase F(0) complex subunit a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MT-ATP6</name>
        <name type="synonym">ATP6</name>
        <name type="synonym">ATPASE6</name>
        <name type="synonym">MTATP6</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion"/>
    <reference key="1">
        <citation type="journal article" date="1986" name="J. Biol. Chem." volume="261" first="11680" last="11685">
            <title>Mitochondrial DNA of two independent oligomycin-resistant Chinese hamster ovary cell lines contains a single nucleotide change in the ATPase 6 gene.</title>
            <authorList>
                <person name="Breen G.A.M."/>
                <person name="Miller D.L."/>
                <person name="Holmans P.L."/>
                <person name="Welch G."/>
            </authorList>
            <dbReference type="PubMed" id="3017940"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit c (ATP5MC1), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) = H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Interacts with DNAJC30; interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion inner membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="M14311">
        <property type="protein sequence ID" value="AAA68616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B25188">
        <property type="entry name" value="B25188"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P14413"/>
    <dbReference type="SMR" id="P14413"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.220:FF:000004">
        <property type="entry name" value="ATP synthase subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000082110" description="ATP synthase F(0) complex subunit a">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="226" mass="25040" checksum="E90B091319B533F4" modified="1990-01-01" version="1">MNENLFSSFITPTLMGLPIIILIIMFPPVIMTSSKRLVNNRFHTFQQWLIKLITKQMMAIHSPKGRTWSLMLASLIIFIGSTNLLGLLPHTFTPTTQLSMNLGMAIPPWAGAVILGFRHKMKDSLAHFLPQGTPIPLIPMLVIIETISLFIQPMALAVRLTANITAGHLLMHLIGGATLVLTSISLPTAMITFIILIMLTILEFAVALIQAYVFTLLVSLYLHDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HWT6</accession>
    <name>A0A061HWT6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G-protein signaling 7-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Regulator of G-protein signaling 9-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Regulator of G-protein signalling 9 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">LOC113837182</name>
        <name evidence="4" type="ORF">H671_21617</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
    </comment>
    <dbReference type="EMBL" id="KE690703">
        <property type="protein sequence ID" value="ERE47772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286096.1">
        <property type="nucleotide sequence ID" value="XM_027430295.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HWT6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007785.1">
        <property type="protein sequence ID" value="ENSCGRP00001005099.1"/>
        <property type="gene ID" value="ENSCGRG00001006642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113837182"/>
    <dbReference type="KEGG" id="cge:113837182"/>
    <dbReference type="GeneTree" id="ENSGT00940000153725"/>
    <dbReference type="OrthoDB" id="6358515at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120200">
        <property type="term" value="C:rod photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026512">
        <property type="entry name" value="RGS7BP/RGS9BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21029">
        <property type="entry name" value="R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ERE47772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027286096.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25118" checksum="25DDF97AF2A6FBA1" modified="2014-09-03" version="1">MAREECKALLDALNKTTACYHHLVLTVGGSADTQDLREELQKTRQKARELAVATGARLTVALRDRGLASEERAEFERLWVAFSGCLDLLEADMRRSLALGAAFPLHAPRRPLVRTGVAGGSSAVAARALSARSLRHEAEGDFDVADLPELEREVLQVGEMIDDMEMKVNVPRWTVQARQAAGAELLSAASAGASSAGGVSVEERAGPCDPSKALAATVFGAVLLMAVILALCVANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I1N7</accession>
    <name>A0A061I1N7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pyroglutamylated RF-amide peptide receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">AQ27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">G-protein coupled receptor 103</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Orexigenic neuropeptide QRFP receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">SP9155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Qrfpr</name>
        <name evidence="20" type="ORF">H671_8g19708</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
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                <person name="Borth N."/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        </citation>
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            <strain evidence="22">17A/GY</strain>
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    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
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        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
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    </reference>
    <comment type="function">
        <text evidence="11">Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.</text>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2 17">Belongs to the G-protein coupled receptor 1 family.</text>
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                <person name="Laux H."/>
                <person name="Kollin F."/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
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                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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                <consortium name="Ensembl"/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Ernst W."/>
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                <person name="Leonard M."/>
                <person name="Grillari J."/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
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                <person name="Lee K.H."/>
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        </source>
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    <reference evidence="17" key="4">
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            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027268052.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35525" checksum="47A542C744B9F5FB" modified="2014-09-03" version="1">MAVKNGSLVTEFILLGITEDPDLQVPLFFLFLLIYMTTILGNLTLIILIVLNSHLHSPMYFFLLNLSLIDLCYSSVITPKMLMKFFLKKNSISYMGCMSQLFLFCSFGITECYMLTAMAYDRYVAICNPLLYNISMSPKVCLYLMLGSYLMGLSGAMVHTGCMLRLTFCDGNIINHYFCDIRPLLQLSCTSTYVNEIGLFTVAGKDIIVPTVIIFTSYGFIISSILKIRSTEGRSKAFNTCSSHIIAVSLFFGSCAFMYLQPSSAWSMDEGKISSIFYTIVIPMMNPLIYSLRNKDVKVSLRKTLSRRIINQNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I6T0</accession>
    <name>A0A061I6T0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Zinc finger protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">Zinc finger protein 878 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">LOC100773813</name>
        <name evidence="15" type="ORF">H671_5g13643</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE676156">
        <property type="protein sequence ID" value="ERE74154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007645719.1">
        <property type="nucleotide sequence ID" value="XM_007647529.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272711.1">
        <property type="nucleotide sequence ID" value="XM_027416910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I6T0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017636.1">
        <property type="protein sequence ID" value="ENSCGRP00001013399.1"/>
        <property type="gene ID" value="ENSCGRG00001014545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773813"/>
    <dbReference type="KEGG" id="cge:100773813"/>
    <dbReference type="GeneTree" id="ENSGT00950000182755"/>
    <dbReference type="OMA" id="STCRVHE"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000339">
        <property type="entry name" value="zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000156">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000564">
        <property type="entry name" value="zinc finger protein 699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE74154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027272711.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51701" checksum="0CEFF6847157E8B9" modified="2014-09-03" version="1">MDCLTFDDVAVNFTLEEWDLLDPSQKQLYTDVMQETFKNLVAIGQTEEGQRIEDDGHFRRNLRNGIVELLFEPSEGRQCEEIFSQFPDTVMNKKIHHGLKLCESKLCADVLVGLPPLNMHKRVPTGHKPYEYEIYGDGLYKFKECRKAFMYPECFLKHENNHRVEKPYKCQQCGKAFSSSSKVRRHERTHTGEKPYICNHCGKAFPSRGSLRRHDRIHSGEKPFVCKYCGKAFTGQSSLPRHERIHSGEKPYVCKYCGKCFISSSTCRVHERTHTGEKLYVCNLCNKAVTTRTSLRNHERIHSGEKPYVCEQCGKGFISSGTFRIHERIHTGEKPYKCKECGKAFTIQSSLQRHERIHTREKPYDCKECGKAFSGYSSLRRHERIHSGERPYACKQCGKAFPALGDCQRHEQIHTGEKPYICKQCGKAFTRCGSLRIHEKTHTRENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061III2</accession>
    <name>A0A061III2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FERM domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Frmd3</name>
        <name evidence="10" type="ORF">H671_2g5739</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
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            <name>Ca(2+)</name>
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        </cofactor>
        <cofactor evidence="18">
            <name>Mg(2+)</name>
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        </cofactor>
        <cofactor evidence="18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the type II topoisomerase family.</text>
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        <property type="protein sequence ID" value="ENSCGRP00001021489.1"/>
        <property type="gene ID" value="ENSCGRG00001020296.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:heterochromatin"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="term" value="P:forebrain development"/>
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        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
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    </dbReference>
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        <property type="entry name" value="Topo_IIA_A_a_sf"/>
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        <property type="entry name" value="Topo_IIA_B_C"/>
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        <property type="entry name" value="DNA TOPOISOMERASE 2-BETA"/>
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        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TOPISMRASEII"/>
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        <property type="entry name" value="TPI2FAMILY"/>
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    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="464"/>
            <end position="581"/>
        </location>
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    <feature type="domain" description="Topo IIA-type catalytic" evidence="21">
        <location>
            <begin position="724"/>
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        </location>
    </feature>
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        <location>
            <begin position="1098"/>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1245"/>
            <end position="1586"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1322"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1346"/>
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        </location>
    </feature>
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        <location>
            <begin position="1362"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1417"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1443"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1526"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1550"/>
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        </location>
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        <location>
            <position position="814"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS52040"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ERE89862.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
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    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027245183.1"/>
        </source>
    </evidence>
    <sequence length="1612" mass="182075" checksum="C01D6FC40620FC68" modified="2015-01-07" version="1">MAKSSLAGADGALTWVNNAAKKEELETSNKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLAKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVRAWKEAQEKAAEEEDTQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQEREDILAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIVPEITAMKADASRKLLKKKKGDPDTPVVKVEFDEEFSGTPVEGTGEETLTPSAPVNKGPKPKREKKEPGTRVRKTPTSAGKPNAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEEEDADDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYAFSPGKSKATPEKSSHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDTASVFTPSFGLKQTDKVPSKTVAAKKGKPPSDTAPKAKRAPKQKKVVETVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKPSKTASKKPKKTSFDQDSDVDIFPSDFTSEPPALPRTGRARKEVKYFAESDEEEDVDFAMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H851</accession>
    <name>A0A3L7H851_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Basic helix-loop-helix family, member e41</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Class E basic helix-loop-helix protein 41 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Bhlhe41</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007646812.2">
        <property type="nucleotide sequence ID" value="XM_007648622.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285916.1">
        <property type="nucleotide sequence ID" value="XM_027430115.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H851"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000103.1">
        <property type="protein sequence ID" value="ENSCGRP00001000079.1"/>
        <property type="gene ID" value="ENSCGRG00001000097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759250"/>
    <dbReference type="KEGG" id="cge:100759250"/>
    <dbReference type="CTD" id="79365"/>
    <dbReference type="GeneTree" id="ENSGT00940000161014"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043426">
        <property type="term" value="F:MRF binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010832">
        <property type="term" value="P:negative regulation of myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010944">
        <property type="term" value="P:negative regulation of transcription by competitive promoter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19750">
        <property type="entry name" value="bHLH-O_DEC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000020">
        <property type="entry name" value="class E basic helix-loop-helix protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="13">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027285916.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="43867" checksum="40BBB43142D63AFA" modified="2019-02-13" version="1">MDEGIPHLQERQLLEHRDFIGLDYSALYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVSHLHAVATQLLTPQVPPGRVPGRAPCSTGAAAAPGPDRAARCVPVIQRTQPGTEPEHDTDTDSGYGGEAEQGRAAIKQEPPGDPSPAPKRPKLEARGALLGPEPALLGSLVALGGGSPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIPAAAAAAAAAFPCLSSVLSPPPEKAGAAAGVPLLAHEVAPPGPLRPQHAHSRTHLPRAGNPESSQEDASQPAKDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HJ10</accession>
    <name>A0A3L7HJ10_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pleckstrin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Plek2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Lamellipodium membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003498318.1">
        <property type="nucleotide sequence ID" value="XM_003498270.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274152.1">
        <property type="nucleotide sequence ID" value="XM_027418351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HJ10"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018654.1">
        <property type="protein sequence ID" value="ENSCGRP00001014417.1"/>
        <property type="gene ID" value="ENSCGRG00001015296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761631"/>
    <dbReference type="KEGG" id="cge:100761631"/>
    <dbReference type="CTD" id="26499"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
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            <begin position="139"/>
            <end position="225"/>
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    <sequence length="353" mass="40034" checksum="8B36BAA7CB2DBFBD" modified="2019-02-13" version="1">MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLLYYKLEGGRRVTPPKGRILLDGCTITCPCLEYENRPLLIKLKTRTSTEYFLEACSREERDSWAFEITGAIHSGQPGKVQQLHIQKNSFKLPPHISLHRIVDKMHDSSSGIRPCPNMEQGSTYKKTFLGSSLVDWLISSSFAASRLEGVTLASMLMEENFLRPVGVRSMGAIRAGDLVEQFLDDSTALYTFAESYKKKVSSKEEISLSTMELSGVVVKQGYLSKQGHKRKNWKVRRFVLRRDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HX59</accession>
    <name>A0A3L7HX59_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 15">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Fah</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_027263373.1">
        <property type="nucleotide sequence ID" value="XM_027407572.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035293592.1">
        <property type="nucleotide sequence ID" value="XM_035437701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HX59"/>
    <dbReference type="SMR" id="A0A3L7HX59"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029003.1">
        <property type="protein sequence ID" value="ENSCGRP00001024757.1"/>
        <property type="gene ID" value="ENSCGRG00001022569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757944"/>
    <dbReference type="KEGG" id="cge:100757944"/>
    <dbReference type="CTD" id="2184"/>
    <dbReference type="GeneTree" id="ENSGT00390000008646"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:L-arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="17">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="16">
        <location>
            <begin position="126"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027263373.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46091" checksum="0898AE537401172F" modified="2019-02-13" version="1">MSYIPVAEDSDFPIQNLPYGVFSTQSHPKPRIGVAIGDQILDLSVIKHLFTGPVLSKHQHVFDETTLNSFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASAKMHLPASIGDYTDFYSSRPHATNVGIMFRGKENALMPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGASKLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVSNPEQDPKPLPYLCHKQPYTFDINLSVALKGEGMSQAATICRSNFKNMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSEPGSFGSMLELSWRGTKAIDLGQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPALTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I0C9</accession>
    <name>A0A3L7I0C9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2</fullName>
            <ecNumber evidence="18">2.4.3.2</ecNumber>
            <ecNumber evidence="19">2.4.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Gal-NAc6S</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Monosialoganglioside sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">ST3Gal II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">ST3GalA.2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Sialyltransferase 4B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36 39" type="primary">St3gal2</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
            <tissue evidence="39">Liver</tissue>
        </source>
    </reference>
    <reference evidence="36" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:139596"/>
            <dbReference type="EC" id="2.4.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:21617"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27938"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:88069"/>
            <dbReference type="ChEBI" id="CHEBI:90151"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:77709"/>
            <dbReference type="ChEBI" id="CHEBI:78445"/>
            <dbReference type="EC" id="2.4.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:18022"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate = a globoside MSGG + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:140623"/>
            <dbReference type="ChEBI" id="CHEBI:140691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:65373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>ganglioside GM1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GD1a (18:1(4E)/18:0) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73110"/>
            <dbReference type="ChEBI" id="CHEBI:90153"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48249"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycolipid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="28">Homodimer; disulfide-linked. Homodimer formation occurs in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.2" evidence="18"/>
    <dbReference type="EC" id="2.4.3.4" evidence="19"/>
    <dbReference type="RefSeq" id="XP_003501120.3">
        <property type="nucleotide sequence ID" value="XM_003501072.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261818.1">
        <property type="nucleotide sequence ID" value="XM_027406017.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I0C9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025052.1">
        <property type="protein sequence ID" value="ENSCGRP00001020808.1"/>
        <property type="gene ID" value="ENSCGRG00001019838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767717"/>
    <dbReference type="KEGG" id="cge:100767717"/>
    <dbReference type="CTD" id="6483"/>
    <dbReference type="GeneTree" id="ENSGT00940000156356"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047288">
        <property type="term" value="F:beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003836">
        <property type="term" value="F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009101">
        <property type="term" value="P:glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23979">
        <property type="entry name" value="GT29_ST3GAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000002">
        <property type="entry name" value="CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051757">
        <property type="entry name" value="Beta-gal_alpha2-3_sialyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46032">
        <property type="entry name" value="ALPHA-2,3-SIALYLTRANSFERASE ST3GAL I ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46032:SF4">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 35" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="276"/>
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        <source>
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    <sequence length="350" mass="39973" checksum="166F1D21FBC3ABD4" modified="2019-02-13" version="1">MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALGGTHRVKLVPGYTGLQRLGKEGLSGKSCACSRCMGDAGTSDWFDSHFDSNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I879</accession>
    <name>A0A3L7I879_CRIGR</name>
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        <recommendedName>
            <fullName evidence="13">Angiogenic factor with G patch and FHA domains 1</fullName>
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        <alternativeName>
            <fullName evidence="14">Angiogenic factor VG5Q</fullName>
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    <gene>
        <name evidence="19 22" type="primary">Aggf1</name>
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    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
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        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="11">Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the secreted angiogenic factor TNFSF12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
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    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="OCRE"/>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
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        <location>
            <begin position="423"/>
            <end position="476"/>
        </location>
    </feature>
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            <begin position="608"/>
            <end position="654"/>
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            <dbReference type="ARBA" id="ARBA00067796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027257506.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="78645" checksum="146981E35FCF82FC" modified="2019-02-13" version="1">MASEAPSPPPASPEPELAQLRRKVEKLERELRSCKRQVREVEKLLHHTERLYQSAESNNQELRTQVEELSKILHCGRYEDRKKSDVEVQTENHAPWSISDYYYQTYYDDSLPSKETDLTAQQSQYAQASTKDESQIDSGSHAGIDGAECVKHGQEDPFTSDSQESASALAAEGTALEGSSIADSLRAAAEAAVSQTGFTYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSSIKPSKDKKLKKRRKEPGFCTANDEKDLSSEDQNICSIEYINCSEEENSANMKKKARIDTAYRSSPLTLTVPVSGGTAASPGDDNSASSKDEKIRESESEPEEGEITDSQSENSYDEDSTSENKGSSEESEDEVEEEKIWPPCIRVIVVRSPVLQTGSLFIITAVNPATIGREKDMEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTVVNGKQILQPKTKSDPYVLEHGDEVKIGETVLSFHIHPGSETCDGCEPGQVRAHLRLDKKGEPFVGPALSKEEKELERRKALKKIRVKYGLQNTDYEDEKALKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWRKGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKPSSVDDLHFLQNKSKTNWDKARERFAENFTETKPLKDSPGAMPWVKGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LA21</accession>
    <name>A0A8C2LA21_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Clcn4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003508814.1">
        <property type="nucleotide sequence ID" value="XM_003508766.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287643.1">
        <property type="nucleotide sequence ID" value="XM_027431842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LA21"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001200.1">
        <property type="protein sequence ID" value="ENSCGRP00001001176.1"/>
        <property type="gene ID" value="ENSCGRG00001000904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762547"/>
    <dbReference type="CTD" id="1183"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000001">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000001">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002246">
        <property type="entry name" value="Cl_channel-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF2">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01115">
        <property type="entry name" value="CLCHANNEL4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0129">CBS domain</keyword>
    <keyword evidence="13 15" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="600"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="697"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027287643.1"/>
        </source>
    </evidence>
    <sequence length="760" mass="84911" checksum="7F5C6F545EE0FF37" modified="2022-01-19" version="1">MVSAGAMSASGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLLSQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFTRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVITIFTFGMKIPSGLFIPSMAVGAMAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LCF0</accession>
    <name>A0A8C2LCF0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zinc finger protein 263</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Zinc finger protein FPM315</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zinc finger protein with KRAB and SCAN domains 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Znf263</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor. Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression. Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with a number of proteins involved in chromatin modification and transcriptional corepression including DNMT1, DNMT3A, HDAC2, PHF8, TRIM28/KAP1, SETDB1, EZH2, UHRF1, CBX3/HP1-gamma, and CBX5/HP1-alpha; recruits these proteins to the SIX3 promoter region, leading to SIX3 transcriptional repression. Interacts with MAPK3/ERK1 and MAPK1/ERK2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003508751.1">
        <property type="nucleotide sequence ID" value="XM_003508703.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279839.1">
        <property type="nucleotide sequence ID" value="XM_027424038.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LCF0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000976.1">
        <property type="protein sequence ID" value="ENSCGRP00001000952.1"/>
        <property type="gene ID" value="ENSCGRG00001000735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765651"/>
    <dbReference type="KEGG" id="cge:100765651"/>
    <dbReference type="CTD" id="10127"/>
    <dbReference type="GeneTree" id="ENSGT00940000159965"/>
    <dbReference type="OMA" id="QQVTNQG"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001749">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003262">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002887">
        <property type="entry name" value="Zinc finger protein 263 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000953">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF377">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="23">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="24">
        <location>
            <begin position="219"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="271"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027279839.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="77822" checksum="21C6E6204ECE8ECE" modified="2022-01-19" version="1">MTMAAGPGSQEPEGLLIVKLEEDCTWSQEVPPPDPEPSPEASHLRFRRFRFQEAAGPREALSQLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELRPESGEEAVTLVERMQRELGKLRQQVTNQGRGAEVLLEEPLPLETAGESPSFKLEPMETERSPGPRLQELLDPSPKRDPQAVKERALSAPWLSLFPPEGNMEDKDMTGSQLPENFEDVAMYISQEWGHQDPSKRALSREMVQDSYENVGTLESCIPGQEVISTQVEQGGKPWDPSVQSCKGGRSPRDPVPGVDKFENPERSVESVSPESAHPPVLLPGQARREVPWSPEQGRPDDREEGHWECPPEDKIEESLVGTTNCRGLVQPKEQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAEKLCMDVECGEVFGGHPHFLSLHRTHIGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPYQCNVCGKSFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYRCSECGKSFSRSSHLVIHERTHEKERLDPLPECGQGINNDSATFLTNHGAHRVEKKLFECLTCGKSFRQGMHLTRHQRTHTGEKPYKCTLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLTSHQRTHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LLG2</accession>
    <name>A0A8C2LLG2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA demethylase ALKBH5</fullName>
            <ecNumber evidence="4">1.14.11.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alkylated DNA repair protein alkB homolog 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Alkbh5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Interacts with RBM33; promoting desumoylation by SENP1 and recruitment to N(6)-methyladenosine-containing mRNAs. Interacts (when acetylated by KAT8) with PSPC1; interaction facilitates recognition of N(6)-methyladenosine (m6A) mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027283092.1">
        <property type="nucleotide sequence ID" value="XM_027427291.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LLG2"/>
    <dbReference type="SMR" id="A0A8C2LLG2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005063.1">
        <property type="protein sequence ID" value="ENSCGRP00001003503.1"/>
        <property type="gene ID" value="ENSCGRG00001004268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755624"/>
    <dbReference type="KEGG" id="cge:100755624"/>
    <dbReference type="CTD" id="54890"/>
    <dbReference type="GeneTree" id="ENSGT00390000009298"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042382">
        <property type="term" value="C:paraspeckles"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046630">
        <property type="term" value="P:gamma-delta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010793">
        <property type="term" value="P:regulation of mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000002">
        <property type="entry name" value="RNA demethylase ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032860">
        <property type="entry name" value="ALKBH5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32074">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32074:SF2">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="17">
        <location>
            <begin position="115"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="294"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027283092.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44443" checksum="264EC7195E47F63A" modified="2022-01-19" version="1">MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAAAAAAEPYPVSGTTKRKYQEDSDPERSDYEEQQLQKEEEARKVKSGIRQIRLFSQDECSKIEARIDEVVSRAEKGLYNEHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSSTLPPNYTSDRLSGNSRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCPEGAGSPTRKVKMRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LTD4</accession>
    <name>A0A8C2LTD4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="18">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Usp4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with RB1 (both dephosphorylated and hypophosphorylated forms). Interacts with RBL1 and RBL2. Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct. Interacts with SART3; recruits USP4 to its substrate PRPF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the peptidase C19 family. USP4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="18"/>
    <dbReference type="RefSeq" id="XP_027270360.1">
        <property type="nucleotide sequence ID" value="XM_027414559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LTD4"/>
    <dbReference type="SMR" id="A0A8C2LTD4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013590.1">
        <property type="protein sequence ID" value="ENSCGRP00001009383.1"/>
        <property type="gene ID" value="ENSCGRG00001011482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771478"/>
    <dbReference type="KEGG" id="cge:100771478"/>
    <dbReference type="CTD" id="7375"/>
    <dbReference type="GeneTree" id="ENSGT00940000156645"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031685">
        <property type="term" value="F:adenosine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
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        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="term" value="P:negative regulation of protein ubiquitination"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="DUSP-like"/>
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    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pept_C19_DUSP"/>
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        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
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    <keyword evidence="10 18 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 18" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
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        <location>
            <begin position="302"/>
            <end position="922"/>
        </location>
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        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="641"/>
            <end position="701"/>
        </location>
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        <location>
            <begin position="930"/>
            <end position="963"/>
        </location>
    </feature>
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        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00000707"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
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    </evidence>
    <sequence length="963" mass="108364" checksum="6141848428081714" modified="2022-01-19" version="1">MAEGRGSRERPDVETQKTELGALMGTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTIQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKPSASPYSSVSASLIANGDGTNTSGMHSSGVSRGGSGFSASYNCQEPQSPHTQPGLCGLGNLGNTCFMNSALQCLSNTAPLTEYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDTHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFILDGLHEDLNRVKKKPYLEPKDASGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPQCRPIQCRVTVPLMGAISDLCEALAKLSGIAAENMVVTDVYNHRFHKIFQMDEGLSHIMPRDDIFVYEVCNTSMDGSECITLPVYFREKKSRPSSTSSGAVLYGQPLLVSVPKHKLTLEALYQAVCDRISRYIKQPLPDEFLSSPLEPGACNGSRSSYEGDDDEEMDHQEEGKEHLSETEGSGEDEQGDGPSEPTHKVKGQPGHRRLFTFSLVNSYGTADINSLATDGKLLKLNSRSTLAIDWDSETRSLYYDQQESEACEKHVSMSQPQKKKKTAVALRECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPVRGLNMSEFVCDRSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDECHNAPLLTSFPGSSDGGMRLGSSQQGLGDDEASSMDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LW42</accession>
    <name>A0A8C2LW42_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GRB2-associated-binding protein 1 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Growth factor receptor bound protein 2-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Gab1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027260676.1">
        <property type="nucleotide sequence ID" value="XM_027404875.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LW42"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012523.1">
        <property type="protein sequence ID" value="ENSCGRP00001008395.1"/>
        <property type="gene ID" value="ENSCGRG00001010681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753832"/>
    <dbReference type="KEGG" id="cge:100753832"/>
    <dbReference type="CTD" id="2549"/>
    <dbReference type="GeneTree" id="ENSGT00940000156801"/>
    <dbReference type="OrthoDB" id="67516at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035767">
        <property type="term" value="P:endothelial cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038084">
        <property type="term" value="P:vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01266">
        <property type="entry name" value="PH_Gab1_Gab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000166">
        <property type="entry name" value="GRB2-associated-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046355">
        <property type="entry name" value="Gab1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960:SF5">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027260676.1"/>
        </source>
    </evidence>
    <sequence length="724" mass="80025" checksum="80F7D7CB1CB9EDF7" modified="2022-01-19" version="1">MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEDMNKWVRCICDICGFNPTEEDPVKPLGNSSQAPVDSPFAVSTAPASTQLEASSVTLPPSYQLISLPPHPETLGLQDDPQDYLLLINCQSKKPEPTRTHVDSAKLTSSETDCNDNVPSHKTPASSQSKHGMNGFFQQQMLYDCPPSRAASVSVDSSLYNLPRSYSHDVLPKESPSSTEADGELYVFNTPSGTSSVEAQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQSSKLDTIPDIPPPRPPKPHPTHDRSPVETCGTPRTASDTDSSYCVPTAGMPPSRSNTISTVDLNKLRKDASSQDCYDIPRTFPSDRSSSLEGFHNQSKIKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEPNYVPMTPGTFDFSSFGMQVPPPAHLGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRPKPHGLERTDSQTIADFATRRKAKPAPLEIKPLPEWEELQAPVRSPITRSFARNSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSSMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSMADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPTKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LYZ8</accession>
    <name>A0A8C2LYZ8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor-type tyrosine-protein phosphatase F</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Leukocyte common antigen related</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29 32" type="primary">Ptprf</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
            <tissue evidence="32">Liver</tissue>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 33">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with PTPRF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035294816.1">
        <property type="nucleotide sequence ID" value="XM_035438925.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001012583.1">
        <property type="protein sequence ID" value="ENSCGRP00001008454.1"/>
        <property type="gene ID" value="ENSCGRG00001010673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766403"/>
    <dbReference type="KEGG" id="cge:100766403"/>
    <dbReference type="CTD" id="5792"/>
    <dbReference type="GeneTree" id="ENSGT00940000155060"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035373">
        <property type="term" value="F:chondroitin sulfate proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031102">
        <property type="term" value="P:neuron projection regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048679">
        <property type="term" value="P:regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd05738">
        <property type="entry name" value="IgI_2_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05739">
        <property type="entry name" value="IgI_3_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14629">
        <property type="entry name" value="R-PTP-F-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000027">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000144">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000015">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000128">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000098">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000353">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF9">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14 32" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 24" id="KW-0732">Signal</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678731" description="Receptor-type tyrosine-protein phosphatase F" evidence="24">
        <location>
            <begin position="30"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1261"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="135"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="232"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="321"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="416"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="514"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="609"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="711"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="820"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="918"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="25">
        <location>
            <begin position="1352"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="26">
        <location>
            <begin position="1527"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="25">
        <location>
            <begin position="1639"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="26">
        <location>
            <begin position="1816"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_035294816.1"/>
        </source>
    </evidence>
    <sequence length="1907" mass="212784" checksum="C2DCD1D5253DC822" modified="2022-01-19" version="1">MAPEPAPGRMMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKARTATMLCAASGTPDPEISWFKDFLPVDPTSSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSSVTRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNAEPVSYYGIQYRAAGTDGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFLAEAESDTRIHLSWLLPPQERITKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTVYHFQLAARSDLGVGVFTPTIEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGINREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTAGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEAQPNTIDFGKDDQHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVIGLTTSTTELSWDPPVLAERNGRITNYTVVYRDINSQHELHNFTDDIHLTLFGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPMEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQVDELPDTFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIALERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LZF9</accession>
    <name>A0A8C2LZF9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline rich 30</fullName>
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        <submittedName>
            <fullName evidence="5">Proline-rich protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Prr30</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003497091.1">
        <property type="nucleotide sequence ID" value="XM_003497043.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280197.1">
        <property type="nucleotide sequence ID" value="XM_027424396.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LZF9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015165.1">
        <property type="protein sequence ID" value="ENSCGRP00001010937.1"/>
        <property type="gene ID" value="ENSCGRG00001012712.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764438"/>
    <dbReference type="KEGG" id="cge:100764438"/>
    <dbReference type="CTD" id="339779"/>
    <dbReference type="GeneTree" id="ENSGT00390000005754"/>
    <dbReference type="OrthoDB" id="9807493at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031461">
        <property type="entry name" value="DUF4679"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22235">
        <property type="entry name" value="PROLINE-RICH PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22235:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15728">
        <property type="entry name" value="DUF4679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027280197.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="42954" checksum="62286F12B74EB36B" modified="2022-01-19" version="1">MLPQNKGQALLQNTVPPGCPPQVLSQFLDSPLSNLASLSPHQSLPPSHLPLPSPTQAYFPFSTLPQPHSPGSHFFSSDSNSDFVPLPYSSSLPSSPTFFNQNYTCLPSPHSSASPNYQLCLSPPLTRCSSSLSQVQNSPPGPCQSPSHLQDVHSPTITSPSPSSPTRGIPSNKQTWQWPQSRNTRSPGEAGGCVASKVDPAEFKDPGALARALVVHVGHRRIARDLQLLFLQRLWLGPTHQAPVVEYPVCLVCLQPRTPSCPIPKYKTGPRLVAFPQLLMPCTQGQDSGPLRIGIGFGLRLPRGQAKALHLLPEKKRRGVRPQGEVLRSQTPATQAPAAQVTGTLSQVGSLRSAGLQPPKSNQCSRPPPQAPRQATALPKPRPSPAPKRSPESTLRKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M3Y5</accession>
    <name>A0A8C2M3Y5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">GLIS family zinc finger 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19 20 21">Zinc finger protein GLIS3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 19 20 21" type="primary">Glis3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19 20 21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19 20 21">17A/GY</strain>
            <tissue evidence="19 20 21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007645004.1">
        <property type="nucleotide sequence ID" value="XM_007646814.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262258.1">
        <property type="nucleotide sequence ID" value="XM_027406457.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262259.1">
        <property type="nucleotide sequence ID" value="XM_027406458.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262260.1">
        <property type="nucleotide sequence ID" value="XM_027406459.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027295030.1">
        <property type="nucleotide sequence ID" value="XM_027439229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M3Y5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017206.1">
        <property type="protein sequence ID" value="ENSCGRP00001012970.1"/>
        <property type="gene ID" value="ENSCGRG00001014233.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760016"/>
    <dbReference type="KEGG" id="cge:100760016"/>
    <dbReference type="CTD" id="169792"/>
    <dbReference type="GeneTree" id="ENSGT00940000156896"/>
    <dbReference type="OMA" id="SECGRMQ"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000453">
        <property type="entry name" value="GLIS family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN GLIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="628"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="238"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="685"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027262258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027262259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027262260.1"/>
        </source>
    </evidence>
    <sequence length="933" mass="99936" checksum="ED0699E0920A516B" modified="2022-01-19" version="1">MNGRSCGMSLHRTSRTPQGPGLFSGQHIPPIRASSGPAGLSSCASTPSPIIASLTNSPHLKMSSGAGMAPQSNMAVSPLHLPALSPRRQLLTNGKPQFQATQADGMAAPLTLKHKQQEFGDHFSSNPEKGALGFGPQCKSIGKGSCNNLVVTSSPMMVQRLGPISPPASQVSTACKQISPSLPRAVNAANLNRPPSDSRSLILQESLVSTTLSLTESQSALSVKQEWSQSYRTFPSLSSNHGSQNGMDLGDLLSLPPGTPGSSNSIANSLPPYLFGMENSHSPYPSPRHSASRSHSARSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYINGSRASPANMSPQSEVYGHFLGVRGSCIPQSCAVSTGQKGMLLASGGQALPGYVEDDTLEYERMQQLEHGGLQSGPVNNMVLQPGLPGQEGQSANMLKTERLEEFPGGALDLPSAPPLPPLPAPQGPPPPYHAHPHLHHPELLPHTQPLALAQPGLDEDGEMEDSGGKHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLAVQPLQPATSPRDAAADGAVGCSPGPGPGPELYPAPIFASNHPNRSATAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDASTERFAPPTPSPQHMSPGRIPAPPSLLQRAQPPHTQQPPGSLLKSYHPETNPAFQSNGIHVHGFYGQLQTFCPPHYPDSQRTVPPSSSCSMVPSFEDCLVPTTMGQAGFDVFHRAFSTHSGITVYDLPSASSSLFGEPLRSGPEDPTFLQLSAVDRCPSQLSSVYTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MF72</accession>
    <name>A0A8C2MF72_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 25 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphate carrier protein, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Phosphate transport protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24 25" type="primary">Slc25a3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24 25">17A/GY</strain>
            <tissue evidence="24 25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment. Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP. Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly. May also play a role in regulation of the mitochondrial permeability transition pore (mPTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>phosphate(in) + H(+)(in) = phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:29941"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PPIF; the interaction is impaired by CsA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016834724.1">
        <property type="nucleotide sequence ID" value="XM_016979235.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248422.1">
        <property type="nucleotide sequence ID" value="XM_027392621.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306753.1">
        <property type="nucleotide sequence ID" value="XM_035450862.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316370.1">
        <property type="nucleotide sequence ID" value="XM_035460479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MF72"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019100.1">
        <property type="protein sequence ID" value="ENSCGRP00001014862.1"/>
        <property type="gene ID" value="ENSCGRG00001015631.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758020"/>
    <dbReference type="KEGG" id="cge:100758020"/>
    <dbReference type="CTD" id="5250"/>
    <dbReference type="OMA" id="YKGAIWL"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="58"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="155"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="256"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027248422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035306753.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39554" checksum="DFA3E15F607ECCA1" modified="2022-01-19" version="1">MFSSVAHLARANPFNAPHLQLVHDGLSGPRSPPGPPQRSRHLAAAAVEEYSCEFGSMKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLAKGWAPTFIGYSMQGLCKFGFYEVFKALYSNMLGEENTYLWRTSLYLAASASAEFFADIALAPMEATKVRIQTQPGYANTLREAVPKMYKEEGLNAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECTKAEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSTASQVLQRLGFRGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPASLKKKLGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MF98</accession>
    <name>A0A8C2MF98_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glycerophosphodiester phosphodiesterase domain containing 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">Lysophospholipase D GDPD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Gdpd1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:137009"/>
            <dbReference type="ChEBI" id="CHEBI:137017"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:53185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41143"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85222"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:56461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45544"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:45545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53168"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85217"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:53169"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003503862.1">
        <property type="nucleotide sequence ID" value="XM_003503814.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282149.1">
        <property type="nucleotide sequence ID" value="XM_027426348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MF98"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022257.1">
        <property type="protein sequence ID" value="ENSCGRP00001018013.1"/>
        <property type="gene ID" value="ENSCGRG00001017891.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758659"/>
    <dbReference type="KEGG" id="cge:100758659"/>
    <dbReference type="CTD" id="284161"/>
    <dbReference type="GeneTree" id="ENSGT00940000156673"/>
    <dbReference type="OMA" id="VHVWTID"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08612">
        <property type="entry name" value="GDPD_GDE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052271">
        <property type="entry name" value="GDPD-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758:SF1">
        <property type="entry name" value="LYSOPHOSPHOLIPASE D GDPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="14">
        <location>
            <begin position="40"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027282149.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35901" checksum="758F382F735E3246" modified="2022-01-19" version="1">MSSTAAFCLLSTLGGYLVTSFLLLKYPTLLHQKKKQRFLSRHISHRGGAGENLENTMTAFQHAVNIGTDMLELDCHITKDEQVVVSHDANLKRSTGINVNVSDLKYSELPPYLCKLDVPFQRASKSEGKDTRIPLLKEVFEAFPETPINIDIKVNNNVLIRKVSELVKQYKREHLTVWGNASSEIVEKCFKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSKSHKFLVWLSDTLLMRKALFDHLTARGIQVYVWVLNEEHEFKRAFDLGATGVMTDYPTKLKHFLNNFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MFV5</accession>
    <name>A0A8C2MFV5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium-dependent phosphatase 1</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">LOC100758361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_003502101.1">
        <property type="nucleotide sequence ID" value="XM_003502053.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246349.1">
        <property type="nucleotide sequence ID" value="XM_027390548.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MFV5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022910.1">
        <property type="protein sequence ID" value="ENSCGRP00001018666.1"/>
        <property type="gene ID" value="ENSCGRG00001018339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758361"/>
    <dbReference type="KEGG" id="cge:100758361"/>
    <dbReference type="GeneTree" id="ENSGT00390000004110"/>
    <dbReference type="OMA" id="GVWAWRK"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000127">
        <property type="entry name" value="Magnesium-dependent phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027246349.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18543" checksum="AB7A0AB8CC860DD1" modified="2022-01-19" version="1">MTPLPKLAVFDLDYTLWPFWVDTHVDPPFHKSSDGTIRDRRGQNIQLYPEVPEVLERLQSLGVPVAAASRTGEIQGANQLLELFDLVKYFVHREIYPGSKVAHFERLHHKTGVPFSQMVFFDDEKRNIIDVGTLGVTCIHIQNGMTLQTLTQGLEAFAKAQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MKJ5</accession>
    <name>A0A8C2MKJ5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dysferlin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dystrophy-associated fer-1-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Fer-1-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Dysf</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferlin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027284343.1">
        <property type="nucleotide sequence ID" value="XM_027428542.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001024496.1">
        <property type="protein sequence ID" value="ENSCGRP00001020252.1"/>
        <property type="gene ID" value="ENSCGRG00001019260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756449"/>
    <dbReference type="KEGG" id="cge:100756449"/>
    <dbReference type="CTD" id="8291"/>
    <dbReference type="GeneTree" id="ENSGT00940000156187"/>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098857">
        <property type="term" value="C:membrane microdomain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002280">
        <property type="term" value="P:monocyte activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050765">
        <property type="term" value="P:negative regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033292">
        <property type="term" value="P:T-tubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08373">
        <property type="entry name" value="C2A_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000009">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000021">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000026">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000033">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000037">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000061">
        <property type="entry name" value="dysferlin isoform X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037726">
        <property type="entry name" value="C2A_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012560">
        <property type="entry name" value="Ferlin_A-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF44">
        <property type="entry name" value="DYSFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08165">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01200">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="2080"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="238"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="394"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1170"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1344"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1595"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1829"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="172"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2029"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060070"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027284343.1"/>
        </source>
    </evidence>
    <sequence length="2114" mass="240718" checksum="811DB264DA95503E" modified="2022-01-19" version="1">MLCCLVARASNLPNVKKDQRSDPVASLIFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNRFLGEAKIPLQEVLATPSLSASFNAPLLDTKQQPTGASLVLQVSYTPPPGAVPLFPPPASLAPSPTLPDMDLVAGGGQSRAETWSLLSDSTMDTRYSGKKWPAPTDTGGEEDTEDQGLTGDEAEPFLDQSGAVGPGGPTTPKKLPSHPPPHHPGAKRKRSSAPPRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIQKGNSPVFNETLFFNVFDSPSELFDEPIFITVVDSRSLRTDALLGEFRMDVGTVYREPRHAYLRKWLLLSDPDDFSAGARGYLKASLCVLGPGDEAPLERKDPSEDKEDIEGNLLRPTGVALRGAHFCLKLFRAEDLPQMDDAVMDNVKQIFGFDSNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRVMDWDRLTHNDTVATTYLGMSKISASGGEIEEEPAGVLKPPKATDLDDNLGFLPTFGPCYVNLYGSPREFTGFPDPYAELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDTTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLRIADRLEASLEQIHLALKAQCSSEDMDALVAQLTDELLADCSQPLCDIHEIPSATHLDQYLFRLRTCHLNQIKEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIIIWMLQGDKRVAYQRVPTHEVLFSRRGPSYCGRNCGKLQTIFLKYPMEGVPGTRMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENQTKLALVGNWGTTGLTYPKFSDITGKIKLPKDSFRPSTGWAWAGDWFVCPEKTLLHDADAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPDRKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGMVDDRSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYLYQARDLPAMDKDSFSDPYAIVSFLHQSQKTVVEKNTLNPTWDQTLIFYEIEIFGEPASVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGGQPAGELLAAFELIQREKPAIHHIPGFEMHETSRILDETEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQMASISSPSLVVECGGQTVQSCVIRNLRKNPNFDVCTLFMEVMLPREDLYCPPIVIKVIDNRQFGRRPVVGQCTIRSLEKFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPVQEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLEKVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIIRAFGLQPKDPNGKCDPYIKISIGKKSVNDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVIDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLQLFCQQHRVKAPVYRTDRVTFQDKEYTIEEIEAGRLPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWIDLFPKVLGRPGPPFNITPRKARRFFLRCIIWNTKDVILDDLSLTGEKMSDIYVKGWMVGFEEHKQKTDVHYRSLGGEGNFNWRFVFPFDYLPAEQVCAVAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNHMPKPAKTAEKCSLDQLDDTFHPEWFVSLFEQKTVKGWWPCVTEEGEKKMLAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEEPRRPDTSFLWFTSPYKTMKFILWRRFRCAIILFIILFILLLFLGIFVYAFPNYAAMKLVKPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MTD1</accession>
    <name>A0A8C2MTD1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crumbs family member 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 8">Protein crumbs homolog 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7 8" type="primary">Crb3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7 8">17A/GY</strain>
            <tissue evidence="7 8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007640628.1">
        <property type="nucleotide sequence ID" value="XM_007642438.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301346.1">
        <property type="nucleotide sequence ID" value="XM_035445455.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301347.1">
        <property type="nucleotide sequence ID" value="XM_035445456.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311332.1">
        <property type="nucleotide sequence ID" value="XM_035455441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MTD1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027778.1">
        <property type="protein sequence ID" value="ENSCGRP00001023532.1"/>
        <property type="gene ID" value="ENSCGRG00001021736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762804"/>
    <dbReference type="KEGG" id="cge:100762804"/>
    <dbReference type="CTD" id="92359"/>
    <dbReference type="GeneTree" id="ENSGT00950000183101"/>
    <dbReference type="OrthoDB" id="9949034at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035003">
        <property type="term" value="C:subapical complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679046" evidence="3">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035301346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035301347.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12663" checksum="177514677D0555EA" modified="2022-01-19" version="1">MATPGLRQLLLAFGLPMLPAGWSQTTPDFFTSNVTLPPDSGSNGGLSSEAVVAIIVVFSILGVILLAVLLFLLVRKLREKRQTEGTYRPSSEEQFSHAAAEARAPQDSKEPVRGCLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N5X5</accession>
    <name>A0A8C2N5X5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="3">1.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Zinc-binding alcohol dehydrogenase domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Ptgr3</name>
        <name evidence="21" type="synonym">Zadh2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57402"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027259515.1">
        <property type="nucleotide sequence ID" value="XM_027403714.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N5X5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029692.1">
        <property type="protein sequence ID" value="ENSCGRP00001025446.1"/>
        <property type="gene ID" value="ENSCGRG00001023041.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cge:100762407"/>
    <dbReference type="GeneTree" id="ENSGT00920000149172"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08250">
        <property type="entry name" value="Mgc45594_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000023">
        <property type="entry name" value="Prostaglandin reductase 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="17">
        <location>
            <begin position="44"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027259515.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="40277" checksum="25FC73912E2FB837" modified="2022-01-19" version="1">MLRLTAAGARAIVDMSYARHFLDFQGSAIPRAMQKLVVTRLSPNFREAVTLRRDCPVPLPGDGDLLVRNRFVGINASDINYSAGRYDPSVKPPFDIGFEGIGEVVALGLSASARYTVGQAVAYVAPGSFAEYTVVPANIAIPLPSVKPEYLTLLVSGTTAYISLKELGGLSEGKKVLVTAAAGGTGQFAVQLSKIAKCHVIGTCSSDKKLAFLKSIGCDRPINYKAEAVHAVLKQEYPDGVDVVYESVGGAMFDLALDALATKGRLIIIGFISGYQSPAGLSPIKAGALPAKLLKKSASLQGFFLNHYFSKYQAAMEHLLELYAHGELVCEVDLGHLAPEGRFIGLDSIFRAVDYMYTGKNTGKLVVELPHCVSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QJL1</accession>
    <name>A0A8C2QJL1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-hydroxytryptamine receptor 2C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Serotonin receptor 2C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Htr2c</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="21">17A/GY</strain>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="14">Interacts with MPDZ. Interacts with ARRB2. Interacts with MPP3; this interaction stabilizes the receptor at the plasma membrane and prevents the desensitization of the HTR2C receptor-mediated calcium response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_035450077.1"/>
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        <property type="nucleotide sequence ID" value="XM_035460068.1"/>
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        <property type="gene ID" value="ENSCGRG00001017187.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="component" value="Chromosome X"/>
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        <property type="term" value="C:dendrite"/>
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        <property type="term" value="C:G protein-coupled serotonin receptor complex"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:synapse"/>
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        <property type="project" value="GOC"/>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="5" type="primary">Ccdc138</name>
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    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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        </lineage>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="CCDC138"/>
    </dbReference>
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        <property type="entry name" value="CCDC138_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048751">
        <property type="entry name" value="CCDC138_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34523">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34523:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21035">
        <property type="entry name" value="CCDC138_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21037">
        <property type="entry name" value="CCDC138_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil-domain-containing protein 138 coiled-coil" evidence="3">
        <location>
            <begin position="282"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="2">
        <location>
            <begin position="381"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027244143.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="78975" checksum="A6A99A9D042F33FF" modified="2023-06-28" version="1">MERRVVKPPGQDMIVERLKSLYGLAGSCSVEQEFSNFDQTKYKRRILTSPEDLDTYCSGDRGVSSLRCYSDERKHPTTPFCSSFKHLNVNCLDDELDSFHNLKKWETEKELTEDDHRDSASKITKQSFREIEKDALPTNIASSRLHTEHHSDSVDSPLKHVIYPKSKVSNKQSLLPHQINQIYDELFHIHLKLQCETASQQKFAEELQQREWFLAEREQLLFRHETALSKIKGVEEEVLTRFQILKEDPMWFGPVQALDMLPHSQHNTEVGHLTEVLKEKNKESKRMRSSFDALRELNDNLRKQLHEVSEENRKMEIQAKRVQARLDNLQRKYEFMTIQRLKEDSHATHEMKSLKQEKAPVSKPVKTALSGQVYELLIVFMDWISDHHLNKVEPEEPGVDGEKPSFKPFQKSDIQEKCVKLLPLMTEQLQWMPLVNPKIHEPFLKFIYWSLRQLHPGTQHSTMTSTLRRLGEDIFKGVAIKGTQDNSSEHSVENRPKTAAFFKSSSLSLRFLSTLIVLKTVTQADYLAQAFDSLCLDLKTDEGKTLFLEYQAVPVILKHLRISSKGLLSNAIDSLLQMTVESKSLQPFLEACSNSLFFRTCSVLLRTPKLDLHILEKLSIILQKLSKIKSNKKLFEVFTIHLMLQEIQRTTHPEHAFLCINLNSTLFNLGLTKCNSLTSSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F608</accession>
    <name>A0A9J7F608_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Palmitoyltransferase</fullName>
            <ecNumber evidence="16">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Zdhhc17</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="16"/>
    <dbReference type="RefSeq" id="XP_027248240.1">
        <property type="nucleotide sequence ID" value="XM_027392439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F608"/>
    <dbReference type="GeneID" id="100764376"/>
    <dbReference type="KEGG" id="cge:100764376"/>
    <dbReference type="CTD" id="23390"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000035">
        <property type="entry name" value="Palmitoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF18">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="17">
        <location>
            <begin position="439"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027248240.1"/>
        </source>
    </evidence>
    <sequence length="633" mass="72770" checksum="D8C4F53CEC5C6935" modified="2023-06-28" version="1">MQREEGFNTKMADGPDEYDTETGCVPLLHPEQEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGGNVDAQNVKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCVSYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQITCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F841</accession>
    <name>A0A9J7F841_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-ureidopropionase</fullName>
            <ecNumber evidence="11">3.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-alanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">N-carbamoyl-beta-alanine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Upb1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:37339"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:74414"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:11184"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer, homotetramer, homooctamer; can also form higher homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_027250004.1">
        <property type="nucleotide sequence ID" value="XM_027394203.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027296361.1">
        <property type="nucleotide sequence ID" value="XM_027440560.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F841"/>
    <dbReference type="GeneID" id="100762944"/>
    <dbReference type="KEGG" id="cge:100762944"/>
    <dbReference type="CTD" id="51733"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07587">
        <property type="entry name" value="ML_beta-AS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000009">
        <property type="entry name" value="Beta-ureidopropionase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="15">
        <location>
            <begin position="72"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027250004.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45590" checksum="F0869693689868DD" modified="2023-06-28" version="1">MAGPEWQSLEQCLEQHLPPDELGEVKRILYGKQTRKLDLPRKALETAAERNFELKGYAFEAAKEQRRCPQIVRVGLVQNRIPLPTSTPVAEQVSALHKRIESIVEVAAMCGVNIICFQEAWNMPFAFCTREKLPWTEFAESAEDGLTTRFCQKLAKRHNMVVVSPILERDRDHGGVLWNTAVVISNSGLVMGKTRKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPLNWLMYSINGAEIIFNPSATIGELSESLWPIEARNAAIANHCFTCAINRVGQEHYPNEFTSGDGKKAHHDLGYFYGSSYVAAPDGSRTPGLSRNQDGLLVTELNLNLCQQINDFWTFKTLLHPASDLITPPGPRGSQSSGLGCVSHLASFNFTGIHEEVIMQLLVFIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F9T6</accession>
    <name>A0A9J7F9T6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Adhesion G protein-coupled receptor L2 isoform X9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Adgrl2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Synaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027251742.1">
        <property type="nucleotide sequence ID" value="XM_027395941.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100769271"/>
    <dbReference type="KEGG" id="cge:100769271"/>
    <dbReference type="CTD" id="23266"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16006">
        <property type="entry name" value="7tmB2_Latrophilin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22845">
        <property type="entry name" value="Gal_Rha_Lectin_LPHN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000011">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.610:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003924">
        <property type="entry name" value="GPCR_2_latrophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003334">
        <property type="entry name" value="GPCR_2_latrophilin_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF61">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02354">
        <property type="entry name" value="Latrophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01444">
        <property type="entry name" value="LATROPHILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039936443" evidence="19">
        <location>
            <begin position="26"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="991"/>
            <end position="1014"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1035"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
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    <feature type="domain" description="SUEL-type lectin" evidence="22">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
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        <location>
            <begin position="135"/>
            <end position="394"/>
        </location>
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        <location>
            <begin position="468"/>
            <end position="525"/>
        </location>
    </feature>
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        <location>
            <begin position="659"/>
            <end position="837"/>
        </location>
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        <location>
            <begin position="847"/>
            <end position="1088"/>
        </location>
    </feature>
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        <location>
            <begin position="418"/>
            <end position="456"/>
        </location>
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        <location>
            <begin position="1358"/>
            <end position="1400"/>
        </location>
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        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
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        <location>
            <begin position="1364"/>
            <end position="1376"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="318"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023040"/>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="PROSITE" id="PS50221"/>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51132"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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            <dbReference type="RefSeq" id="XP_027251742.1"/>
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    <sequence length="1459" mass="163419" checksum="BEC1947D99D852B9" modified="2023-06-28" version="1">MVSSGCRMRSLWFIIIISFSPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCVVVTGSDVFPDPCPGTYKYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNTIDYIYNTRLSRGEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTTVSTTSTTSQRGPVSTTVAGPQEGSRGTKPPPAVSTTKIPPVTNIFPLPERFCEALDVRGIKWPQTQRGMMVERPCPKGTRGTASYLCLASTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRHEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVDVLSTEGQVQDFKFPLGIKGAGSTIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSLNKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREISYKDGVHELLLTVITWVGILVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYSIACPVFAGLLHFFFLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTQKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFVNEETVVMAYLFTTFNTFQGVFIFIFHCALQKKVRKEYGKCFRHWYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAPSAPVFNSPGHSLNNARDASAMDTLPLNGNFNNSYSLRKGDYHDGVQVVDCGLSLNDTAFEKMIISELVHNNLRGGTKAHNLELKLPVKPVIGGSSSEDDAIVADASSLMHGDNPALEFRHKELEAPLIPQRTHSLLYQPQKKGKPEATDSYVSQLTAEADDHLQSPNRDSLYTSMPNLRDSPYPESSPDMAEDLSPSRRSENEDIYYKSMPNLGAGRQLQMCYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FCN0</accession>
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        <name evidence="11" type="primary">Hes2</name>
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    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
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        <property type="component" value="Chromosome 2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="9">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027253940.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17357" checksum="6FCD7A4764D668B8" modified="2023-06-28" version="1">MRLPRRVGDAAELRKTLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVRFLQEQPVSPYPTAAPEPLDSYLEGYRACLARLARMLPACSVLEPAVSARLLEHLRQRTVSGVPPSQTPTPAPAPAPSPQVPPPGSPGLWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FGK1</accession>
    <name>A0A9J7FGK1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Forkhead box protein D3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113833990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027256154.1">
        <property type="nucleotide sequence ID" value="XM_027400353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FGK1"/>
    <dbReference type="GeneID" id="113833990"/>
    <dbReference type="KEGG" id="cge:113833990"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FH_FOXD3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FH_FOXD3"/>
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    <dbReference type="InterPro" id="IPR001766">
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    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF405">
        <property type="entry name" value="FORKHEAD BOX PROTEIN D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="11">
        <location>
            <begin position="136"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="9">
        <location>
            <begin position="136"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027256154.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="47338" checksum="801C0EAB48761247" modified="2023-06-28" version="1">MTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLDEKDSDAGCDSPAGPPELRLDEADEGPPATAHHGQSQPPHQQPLALPTEATAGGPGNDAGAPEADGCKGGEDAVAGGGGPGAGGGAPGGLTPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSLAAAAGAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPSLQLQLNTLGAAAAAAGTAGAAGTTSLIKSEPSARPSFSIENIIGAGPTAPGGSAGGGGSAGGLGGRGGGGGGSTQSFLRPPGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAVQAKWPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FM72</accession>
    <name>A0A9J7FM72_CRIGR</name>
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        <submittedName>
            <fullName evidence="9">Protein FAM189A1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Fam189a1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ENTREP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263884.2">
        <property type="nucleotide sequence ID" value="XM_027408083.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FM72"/>
    <dbReference type="GeneID" id="100764965"/>
    <dbReference type="KEGG" id="cge:100764965"/>
    <dbReference type="CTD" id="23359"/>
    <dbReference type="OrthoDB" id="10036151at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030431">
        <property type="entry name" value="ENTREP1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17615:SF6">
        <property type="entry name" value="PROTEIN ENTREP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17615">
        <property type="entry name" value="PROTEIN FAM189A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
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        <location>
            <begin position="248"/>
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        </location>
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        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027263884.2"/>
        </source>
    </evidence>
    <sequence length="463" mass="49064" checksum="6C46F08C3494BBEE" modified="2023-06-28" version="1">MTMKGKVFQKGALGAIGNYQAIFPPSLAKWVINLCLVCFQITFFMLLSAVCVMLNLAGSILSCQNAQLVSSLEGCQLIKFDSVEVCVCCELQHHSSGCSNLGETLKLNPLQENCNAVRLTLKDLLFSVCALNVLSTIVCALATAMCCMQMVSADVLQMFFPQRSHSAGAACVTPHGTILHQTLDFDEFIAPLPPPPYYPPEYTCTPTAEAHRGLHLDFASSPFSTLYDVAINSPGMLYPAELPPPYEAVVGQTPASQVPSVDHQVADSSSGDPNTAAGFSTPVPASSTSLPTSEGAASLGPSHPSPDGTLDTPPPLLSTPVPHPMSPEATSLSTQAQPSPGRVARSASDPTSCTSSEAVSALRPAMAACQHQLSSAGNPDTWKMDQGAKPETLQTVSKERPHSLVESKAYMDTRVLVAKFLEHSHCTVPSEVRHVVGTIRSTVTSEEPRVEEAIFGAGVLDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FMJ0</accession>
    <name>A0A9J7FMJ0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Vomeronasal type-2 receptor 116-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100758916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027263734.1">
        <property type="nucleotide sequence ID" value="XM_027407933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FMJ0"/>
    <dbReference type="GeneID" id="100758916"/>
    <dbReference type="KEGG" id="cge:100758916"/>
    <dbReference type="OrthoDB" id="9608793at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06365">
        <property type="entry name" value="PBP1_pheromone_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000009">
        <property type="entry name" value="Vomeronasal 2, receptor 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000024">
        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000687">
        <property type="entry name" value="Vomeronasal 2, receptor 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF409">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039927637" evidence="12">
        <location>
            <begin position="24"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="583"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027263734.1"/>
        </source>
    </evidence>
    <sequence length="854" mass="97504" checksum="4AB9D8DF0D0A2ACF" modified="2023-06-28" version="1">MIKMLSLMVVFLILKLSFLFSSSIEPKCFWRLKTNKNWEGDKDIDCFFSIYTKRGHVKNEHFSENLDKRLTAKNIHLILSLYFALKEINQNPHFLPNISLLVKVECSLLDDWRINSLASKRGEFIPNYYCISQRRYLIVLTGPMWLASAILGPLLYISKTPELYYGPLNPLLSSREQFPYLYQTAPKHTSLALAMVSLMVHFSWNWVGTIISDDDLGLQFLLELRKEMQRNTVCLSIVSIITNDPTVFLKNINIYYSQIMMSSAKVVIIYGDKDSYLQVNLRIWNSMNIQRIWVTTAQWDMIIHEGKFLLNSFYGTLTFIHHYSELTGFKTFIQTTHPTNYSNDISLARLWWMYFNCSLSSFNCKNLKNCSTKTILNWLSKNHSEISLSGTSYDLHNAVYAVAHALHQMLLQQVDTWQSNDGKGLEFDSWRMVPFLENIQFINPAEDQVSLNQKEKLNAKYDIYHTMDILPKLGLKVKIGTFSQYLPHGQQLGMSEEVIKWNTDIKQTPTSMCSVPCSPGFRKSPQQGKAVCCFDCIPCPENEISNMTDMDHCIKCPDDQYDDPGRTHCLKKVVTFLSYEDPLGMSLACLALGFFALTALILCVFLKHQDTPTVKANNRTLSYVLLMALIFCFLCSLLFIGHPVMATCIMQQTIFAIMFTVAASTVLAKTVTVILAFKVTNPSRRLRWLLVSRAPNYIIPIFTMIQLIICGIWLGTYPPFVDADVHAQRGHILIICNKGSIIAFYCVLGYLTSIAIGSFTLAFLARNLPDTFNEAKYLTFSMLVFCSVWVTFLPVYHSTKGKAMVAVEVFCILASSAGLLLCIFGPKCFIILLRPEGNSFQKSRNVHFKIQNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FNL7</accession>
    <name>A0A9J7FNL7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100768654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="RefSeq" id="XP_007649297.1">
        <property type="nucleotide sequence ID" value="XM_007651107.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262344.1">
        <property type="nucleotide sequence ID" value="XM_027406543.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FNL7"/>
    <dbReference type="GeneID" id="100768654"/>
    <dbReference type="KEGG" id="cge:100768654"/>
    <dbReference type="OMA" id="VRHVMIK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07141">
        <property type="entry name" value="ALDH_F1AB_F2_RALDH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000029">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027262344.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="54453" checksum="545B42DBE40B8F79" modified="2023-06-28" version="1">MSQPEVPAPLANLKIQYTKIFINNEWHDSVSGKKFPVINPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLFKLADLMERDRLLLATLEAINGGKVFASSYLFDLGGCIKALKYCAGWADKVHGQTIPSDGDIFTYTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVIVKPAEQTPLTALYMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDTAIEFAHNGVFYHQGQCCVAASRLFVEESIYDEFVRRSVERAKKYVLGNPLNTGINQGPQIDKEQHEKILDLIESGKKEGAKLECGGGRWGNKGYFVQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTSYGLAAGVFTKDVDKAITVSSALQAGVVWVNCYMMLSPQCPFGGFKMSGNGRELGEHGIYEYTELKTVAMKISQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FQC9</accession>
    <name>A0A9J7FQC9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquilin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ubqlnl</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027263840.1">
        <property type="nucleotide sequence ID" value="XM_027408039.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FQC9"/>
    <dbReference type="GeneID" id="100765298"/>
    <dbReference type="KEGG" id="cge:100765298"/>
    <dbReference type="CTD" id="143630"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000095">
        <property type="entry name" value="Ubiquilin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000077">
        <property type="entry name" value="Ubiquilin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF9">
        <property type="entry name" value="UBIQUILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="557"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00074668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027263840.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="66980" checksum="D6C6235A32E6E367" modified="2023-06-28" version="1">MPHIISRTPRMPQSRCPAGMPADGNICPSVIRVIVKTPGHQNNFTVAGDNSVRQFKEKLSARFKCQMDQLVLVFMGRLLKDHDILSHRGITDGHTIHVVIKSKHGSRSLAHSFRNLLTKNPCHQDRSTKGNNSRMCQSAGMGQTKVESSLLTESEAPTQNPEVDSPEHIAQMLENLCVQRMLSNMDCMRQLISEHPDIQELIQQNPEVSHILDNSEILCQTLELARHLAIIQEIMQLNQPAQNFEHPPNPQPYLGLETIPNGNNVLGQSYDFNDQMLNGMQDFLEGNSFTALLAGQVLEQVQTPPLSVPPSEEQWDQAPNAQVIYANSCGLSSITPTNATLNNTNHASRENPVTVTIEGESHVCAVEQPAGVPVLSSTAVTQELQEDKGTTPPLGSSHQWLEEDLQQPDEQTSQITGGMIQLLRNYPHVAAQMLLLMNMPQQNEQWRQQSPTSLQSSQLSDLLLALANPKTSQAILQIEHGLQLLATEAPILLPCIEPYLWSLGWFPLSNSNYTDTVPWALNEPDMAEPQWPECCPKSGTVLQRVQPPSGDPSHCPQAPEVHFSKQMEHLQAMGFVNYNANLQALIATDGDTNAAIHRLKRSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FTJ1</accession>
    <name>A0A9J7FTJ1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan-specific phospholipase D</fullName>
            <ecNumber evidence="4">3.1.4.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Glycoprotein phospholipase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glycosyl-phosphatidylinositol-specific phospholipase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22 23 24 25 26 27" type="primary">Gpld1</name>
    </gene>
    <organism evidence="20 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10832"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57997"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:58700"/>
            <dbReference type="EC" id="3.1.4.50"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPLD1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.50" evidence="4"/>
    <dbReference type="RefSeq" id="XP_007641003.1">
        <property type="nucleotide sequence ID" value="XM_007642813.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641004.1">
        <property type="nucleotide sequence ID" value="XM_007642814.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641005.1">
        <property type="nucleotide sequence ID" value="XM_007642815.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641007.1">
        <property type="nucleotide sequence ID" value="XM_007642817.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016830968.1">
        <property type="nucleotide sequence ID" value="XM_016975479.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265121.1">
        <property type="nucleotide sequence ID" value="XM_027409320.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265122.1">
        <property type="nucleotide sequence ID" value="XM_027409321.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265123.1">
        <property type="nucleotide sequence ID" value="XM_027409322.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265125.1">
        <property type="nucleotide sequence ID" value="XM_027409324.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265126.1">
        <property type="nucleotide sequence ID" value="XM_027409325.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265127.1">
        <property type="nucleotide sequence ID" value="XM_027409326.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265128.1">
        <property type="nucleotide sequence ID" value="XM_027409327.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027292224.1">
        <property type="nucleotide sequence ID" value="XM_027436423.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027292225.1">
        <property type="nucleotide sequence ID" value="XM_027436424.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FTJ1"/>
    <dbReference type="GeneID" id="100759513"/>
    <dbReference type="KEGG" id="cge:100759513"/>
    <dbReference type="CTD" id="2822"/>
    <dbReference type="OMA" id="CGMTTHN"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004621">
        <property type="term" value="F:glycosylphosphatidylinositol phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000010">
        <property type="entry name" value="Glycosylphosphatidylinositol specific phospholipase D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000011">
        <property type="entry name" value="Glycosylphosphatidylinositol specific phospholipase D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001028">
        <property type="entry name" value="Gprt_PLipase_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00718">
        <property type="entry name" value="PHPHLIPASED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0345">HDL</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044698677" description="Phosphatidylinositol-glycan-specific phospholipase D" evidence="18">
        <location>
            <begin position="24"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase C/D" evidence="19">
        <location>
            <begin position="28"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="17">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="17">
        <location>
            <begin position="436"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="17">
        <location>
            <begin position="499"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="17">
        <location>
            <begin position="633"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="17">
        <location>
            <begin position="705"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027265121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027265122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027265123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027265125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027265126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027265127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027265128.1"/>
        </source>
    </evidence>
    <sequence length="841" mass="93606" checksum="3CB1243F0F6EB0C5" modified="2023-06-28" version="1">MPTGRLWSGLLLLLSFFCSRSSSCGLSTHVEIGHRALEFLQLQDGHINYKELLLEHQDAYQAGTVFPDAFYPSICKRGKYHDVSERTHWTPFLNASIHYIRENYPLPWEKDTEKLVAFLFGITSHMVADVSWHSLGIEQGFLRTMGAIDFHDSYSEAHSAGDFGGDVLSQFEFNFNYLSRRWYVPIKDLLRIYDNLYGRKVITENVIVDCTYLQFLEMHGEMLAVSKLYSTYSMKSPFLVEQFQEYFLGGLDDMAFWSTNIYRLTSFMLENGTSDCHLPENPLFITCDGRRNHILGSKVQKNDFHGNLTMFIRKDIRKNLNYTERGVFYSTGSWAPESVTFMYQNLERNLRMMFSGSSQTPLKHVSSPSASYFLSVPYARLGWVMASADLNQDGHSDLVVGAPGYSHPGLFQIGRVYIIYSNDLGLPPINLDLDKEAHGILQGFQPSGRFGSALAVVDFNKDGLPDLAVGAPSVGSGQLTYNGSVYVYYGSQQGTLSPSPNITISCKDTYCNLGWTLLSADMDGDGQPDLVMGSPFAPGGGKQRGIVAAFYSRPRQSDKEILTVEEADWKVSGEEDFSWFGYSLHGVTVTNRTLLLVGSPTWKNVSRLARSSHRNHEKNSLGRVYGYFPPNRQSEITISGDKTMGKLGTSLSSGHVRLNGTLTQVLLLGAPTHDVVSKMAFLTMNLHQGGATRMYELALEKTQPALLSTFSGDRRFSRFGSILHLTDLDDDGLDEIIMAAPLRITDVTSGLLGGEDGRVYIYNGKHTTLGDMTGKCKSWMTPCPEEKAQYVLISPEASSRFGSSLVSVRSKERNQVVVAAGRSSWGARLSGALHVYSLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FYB8</accession>
    <name>A0A9J7FYB8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100772095</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027268077.1">
        <property type="nucleotide sequence ID" value="XM_027412276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FYB8"/>
    <dbReference type="GeneID" id="100772095"/>
    <dbReference type="KEGG" id="cge:100772095"/>
    <dbReference type="OrthoDB" id="9440924at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15406">
        <property type="entry name" value="7tmA_OR8D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027268077.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35096" checksum="4BDC917676A7D662" modified="2023-06-28" version="1">MAAGNHCTVTEFFLAGLSEKPELQMPLFLLFIGIYVVTVVGNLGMVTLIGLSSHLHTPMYYFLSSLSFIDFCQSTVVTPKMLVSFVKKKNLISYPGCMTQLYFFLIFAIAECYILAAMAYDRYVAICNPLLYNVTMSYQIYMSLISGVYIIGVFCASVHTGFMIRMQFCKLDVINHYFCDLLPLLKLAHSNTYINELLILFFGTLNIFVPILTIITSYIFIIASILRIQSTEGRSKAFSTCSSHILAVSVFFGSLAFMYLQPSSVNSMDQGKVSSVFYTIVVPMLNPMIYSLRNKDVTVALRKMLERKTFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FYK9</accession>
    <name>A0A9J7FYK9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Keratin-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100763914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with hair keratins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269036.1">
        <property type="nucleotide sequence ID" value="XM_027413235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FYK9"/>
    <dbReference type="GeneID" id="100763914"/>
    <dbReference type="KEGG" id="cge:100763914"/>
    <dbReference type="OrthoDB" id="9835168at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007951">
        <property type="entry name" value="KRTAP_PMG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05287">
        <property type="entry name" value="PMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0416">Keratin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027269036.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18315" checksum="1A9D896BE611B366" modified="2023-06-28" version="1">MTCDCCSSNSSCSSLRRCLPSSGSSCGSPYPSNLVYTTTSCSPSTCQLGSSLNSGCQETCIEPTICQRSCVVSSPCQTACYYPRSFATCSPCQETYAGCLAFGPSSFQTLECGSRGCYIMGCGPSGCESLYYGVSGFPFQRCGPRFCYSTLLPASTSQAGYKPICGNTLYGVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FZC5</accession>
    <name>A0A9J7FZC5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: coiled-coil domain-containing protein 71L-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113835857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027272808.1">
        <property type="nucleotide sequence ID" value="XM_027417007.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FZC5"/>
    <dbReference type="GeneID" id="113835857"/>
    <dbReference type="KEGG" id="cge:113835857"/>
    <dbReference type="OrthoDB" id="9939459at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026695">
        <property type="entry name" value="Ccdc71/71L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14484">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14484:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 71L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15374">
        <property type="entry name" value="CCDC71L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027272808.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="24882" checksum="12980F5AAE6D4B53" modified="2023-06-28" version="1">MRRGVKRRRRRPRAAWGGGYGADGGAGLQALEEKVVYSRSQLSLAGSTEALGDAFKLFMPSSTEFMSSEAELWSFLCSLKHQFSPHILRSKDVYGYSSCRALVPDLPAPAGRPARRPRPRPTPRRRRRGARAAAGTLGPRPPPPPQPPPSAASAAAEPGPPASCFGGRTLEEIWRAATPTLTSFPTIRVGDDVWGERSLAVARRRASQVLRVDLDPVVRLRRFPVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G145</accession>
    <name>A0A9J7G145_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/arginine-rich splicing factor 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Delayed-early protein HRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor SRP40</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Splicing factor, arginine/serine-rich 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Srsf5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027274212.1">
        <property type="nucleotide sequence ID" value="XM_027418411.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301835.1">
        <property type="nucleotide sequence ID" value="XM_035445944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G145"/>
    <dbReference type="SMR" id="A0A9J7G145"/>
    <dbReference type="GeneID" id="100757287"/>
    <dbReference type="KEGG" id="cge:100757287"/>
    <dbReference type="CTD" id="6430"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12595">
        <property type="entry name" value="RRM1_SRSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12765">
        <property type="entry name" value="RRM2_SRSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000028">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000138">
        <property type="entry name" value="Serine/arginine-rich splicing factor 5 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF59">
        <property type="entry name" value="SERINE AND ARGININE RICH SPLICING FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027274212.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30978" checksum="EA3E8C9E6D10B680" modified="2023-06-28" version="1">MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIEGSKRHSRSRSRSRSRTRSSSRSRSRSRSRRSKSYSRSRSRSRSRSKSRSGSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G1U5</accession>
    <name>A0A9J7G1U5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CSL-type zinc finger-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100758158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase. Interacts with SERGEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027273922.1">
        <property type="nucleotide sequence ID" value="XM_027418121.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G1U5"/>
    <dbReference type="GeneID" id="100758158"/>
    <dbReference type="KEGG" id="cge:100758158"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027273922.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9411" checksum="CCD3EDBF57383774" modified="2023-06-28" version="1">MVVFHDEVEIEDFQYDEDSETYFHPCLCGDNFSITKEDLENGEDVATCPSCSLIIKVIYDKDQFMCGETVPPPSINKELVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G4I9</accession>
    <name>A0A9J7G4I9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Integrin alpha-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">CD49 antigen-like family member F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">VLA-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">Itga6</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
            <tissue evidence="32">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 (ITGB1) or beta-4 (ITGB4) to form ITGA6:ITGB1 and ITGA6:ITGB4, respectively. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3. ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R. ITGA6:ITGB4 interacts with IGF2. Interacts with ADAM9. Interacts with RAB21. Interacts with MDK. ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite outgrowth. Interacts with CD82; this interaction down-regulates ITGA6-mediated cell adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Membrane</location>
            <topology evidence="27">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 27">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027275995.1">
        <property type="nucleotide sequence ID" value="XM_027420194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G4I9"/>
    <dbReference type="GeneID" id="100769534"/>
    <dbReference type="KEGG" id="cge:100769534"/>
    <dbReference type="CTD" id="3655"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000002">
        <property type="entry name" value="integrin alpha-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000002">
        <property type="entry name" value="integrin alpha-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000002">
        <property type="entry name" value="Integrin subunit alpha 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1530:FF:000001">
        <property type="entry name" value="Integrin subunit alpha 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF9">
        <property type="entry name" value="INTEGRIN ALPHA-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 27" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 27 32" id="KW-0401">Integrin</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18 27" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 27" id="KW-0732">Signal</keyword>
    <keyword evidence="7 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039962103" description="Integrin alpha-6" evidence="27">
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            <begin position="24"/>
            <end position="1091"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
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            <begin position="30"/>
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            <begin position="301"/>
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        <location>
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        <location>
            <begin position="420"/>
            <end position="479"/>
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    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="28">
        <location>
            <begin position="464"/>
            <end position="624"/>
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    </feature>
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        <location>
            <begin position="626"/>
            <end position="791"/>
        </location>
    </feature>
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        <location>
            <begin position="797"/>
            <end position="1003"/>
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            <dbReference type="Pfam" id="PF08441"/>
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            <dbReference type="Pfam" id="PF20805"/>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G581</accession>
    <name>A0A9J7G581_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sphingosine 1-phosphate receptor 4</fullName>
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        <alternativeName>
            <fullName evidence="14">Endothelial differentiation G-protein coupled receptor 6</fullName>
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        <alternativeName>
            <fullName evidence="15">Sphingosine 1-phosphate receptor Edg-6</fullName>
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        <name evidence="19" type="primary">S1pr4</name>
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    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_007646959.4"/>
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        <property type="nucleotide sequence ID" value="XM_027419222.2"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038036">
        <property type="term" value="F:sphingosine-1-phosphate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sphingosine 1-phosphate receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004064">
        <property type="entry name" value="EDG6_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004061">
        <property type="entry name" value="S1P_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01526">
        <property type="entry name" value="EDG6RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01523">
        <property type="entry name" value="S1PRECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="65"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027275023.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="41944" checksum="5413FFB1EC563990" modified="2023-06-28" version="1">MSPGEAMNISTWSCHRLAASGHSLLIVLHYNHSGRLAGRGGPEDGGGLGMLRGPSVAAGCLVVLENAVVLAAIATRMRSHRWVYYCLLNITLSDLLTGLAYLVNVLLSGARTFQLSPAHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATKTSRVYGCIGLCWLLAATLGLLPLLGWNCVCAFPRCSSLLPLYSKGYVLFCVVVFALILVAILGLYGAIFRVVRANGQKSPRAPARRKARRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNIWAQEYLRGMDWILALAVLNSAINPLIYSFRSREVQRAVLAFLCCSCLWLGLRGPDDCLIRITEVHSGASTTDSSLRTRDSFRASRSLSFKMREPLSSISSVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G5A7</accession>
    <name>A0A9J7G5A7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Izumo sperm-egg fusion protein 4 isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Izumo4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Izumo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027275119.1">
        <property type="nucleotide sequence ID" value="XM_027419318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G5A7"/>
    <dbReference type="GeneID" id="100759426"/>
    <dbReference type="KEGG" id="cge:100759426"/>
    <dbReference type="CTD" id="113177"/>
    <dbReference type="OrthoDB" id="9904630at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029389">
        <property type="entry name" value="IZUMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052868">
        <property type="entry name" value="Izumo_fusion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37357">
        <property type="entry name" value="IZUMO SPERM-EGG FUSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37357:SF1">
        <property type="entry name" value="IZUMO SPERM-EGG FUSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15005">
        <property type="entry name" value="IZUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039941127" evidence="3">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027275119.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29619" checksum="0C7CEE3BFECE2F12" modified="2023-06-28" version="1">MDEHGRPGQAMALLLCLGMTAALARGCLHCDPNFLPKFSFYRHHVNLKSWWVGDIPVSGVLLTEWSQNTMKELHLAIPAEITREKLEQVAGAVYQRMDQLYQGKMYFPGYFPNELRAIFREQVRLLQNAIIESRIDCQRHCGIFQYQTISCINCTDSHVVCFGYYCKYGLATCSTAHGVPGSPPGHRGDLGFGDTPSASPVFPRSSAQWESAVQGLLSYINTWHKQDIGSRTTPAFLSPRIRCLEPQHLANLTLESASECLTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G7L1</accession>
    <name>A0A9J7G7L1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-type tyrosine-protein phosphatase eta</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-tyrosine phosphatase receptor type J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Ptprj</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 27">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027278416.1">
        <property type="nucleotide sequence ID" value="XM_027422615.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100765394"/>
    <dbReference type="KEGG" id="cge:100765394"/>
    <dbReference type="CTD" id="5795"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14615">
        <property type="entry name" value="R-PTPc-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000009">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000362">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase eta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF5">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="26" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="148"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="386"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="474"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="559"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="738"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="22">
        <location>
            <begin position="1058"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="23">
        <location>
            <begin position="1233"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027278416.1"/>
        </source>
    </evidence>
    <sequence length="1354" mass="149504" checksum="96D250C37CD88D00" modified="2023-06-28" version="1">MTRGGGRGSSRGRRSWKPGATRGGWVSLAPPREAPACLGPRPLRAKRARLRRVAAAAAAAMSPGKPGAGGAGTRRTGWRRRRRRRRLEAGTREPGFGHTAGRVPGTFQGAQGMKPAALETRPPPRSPGLRWALLLLLRLGQVLCAGAAPSPGFDIEAVSSPTNVTLTWKHVSTPSEYTYRIETKMEKNMTFTTAKNQTSYTIRGLSAATSYTFSITPMIANETSGNSTDKNVTTKPWPVSDLQVASKGETQAALNWSDANGTASYRMLLECFGNSKQITPHSAFNISGLKPGSCNICNLLGAEGELQNCASDTNDIERSPVANLSQVHRNFLCSVVLACVQSPSLTQVLLTGLKPGTNYTAKVYPRAADDTEGQPGIKAFTTDSIKVSDIRAVSISATNMTLTWKINNNESSFCYTYKIHVAGGSSAFNQTVNKTEAIIRGLTSSTLYNITICPFLGHDEGESDFLQVYTSPGPVSDFQVTNVSIREIGLTWRSNDSEFRILTMEVGGEKIKNYTTRNQSFIIEDLKPGTSYHFEIFPRGPDGTEGPSRTVDGRTDRSAVIDIRIVSVTSSEMQLEWENTDSTSGYNYHVVLESECGRSNTTSSQKSITLRDLTPGTLYNVTVTPEVEQVQGDATSVAQYTRPSNVSDIEVNTSTTVATIWWNNLDKASPKYSYRLILKAGDGSNVTKMIITDVGITSQMVYDLIPGSSYTVEIFAKVGNVTESLVPGWKSFCMEPAPVAFFHCEVVPKEPVLVLKWPCPPGMNTGFELGVRNDTWNNMTYLKNCNSEDDTECRGKVQNLTFSTSYNISIVTLSCGKMAAPTQSTCTTGITDPPSPDGSPNITSVSHNSVKVKFSGFKASNGPIKAYAIILTTGEAGQPSADVLKYTYEDFKKGASDTYVTYLIRIEEKGRSPGLSEVLKYEIDVGNQSTTLGYYNGRLEPLGSYRVCVAGFTNIAYNLHNEQLINGNESYVSFSQYSEAVFLPQDPGVICGAVFGCIFGALAIVAVGGFVFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYTAEVAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQGRTKCEEYWPSKQAHDYGDITVAMTSEVVLPEWTIRDFVVKNMQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQKDSKVDLIYQNTTAMTIYENLEPVSMFGKTNGYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GCS6</accession>
    <name>A0A9J7GCS6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100763532</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282593.1">
        <property type="nucleotide sequence ID" value="XM_027426792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GCS6"/>
    <dbReference type="GeneID" id="100763532"/>
    <dbReference type="KEGG" id="cge:100763532"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15918">
        <property type="entry name" value="7tmA_OR1_7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027282593.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35462" checksum="A31BF85E09D16D6C" modified="2023-06-28" version="1">MMGNNQTVISQFLLLGMPIPPEHQNMFFTLFLAMYLTTVLGNLLIIILILLDSHLHTPMYLFLSNLSFSDLCFSSVTMPKLLQNMQSRDTFISYVDCLTQMYFLMAFGDMESLLLVVMAYDRYVAICFPLHYTSIMNPKFCACLLMPLWMLTLLDAMMHTMLVARLSFCDDNVIPHFFCDISALLKLACSDTYVNELMIFITGGPIIIVPFLLIVISYARIVSSILKVSSTRGIHKVFSTCGSHLSVVSLFYGTIFGLYFSPSDNNSTVKETTMAMMFTVVTPMLNPFIYSLRNRDIKQALIRLTCKRKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GF32</accession>
    <name>A0A9J7GF32_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Ccdc200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027283888.1">
        <property type="nucleotide sequence ID" value="XM_027428087.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293949.1">
        <property type="nucleotide sequence ID" value="XM_027438148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GF32"/>
    <dbReference type="GeneID" id="113836909"/>
    <dbReference type="KEGG" id="cge:113836909"/>
    <dbReference type="CTD" id="100874261"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027283888.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15721" checksum="12321CE19C6DA903" modified="2023-06-28" version="1">MGSAYHWEARRRQMALERRKALIAQQQEQEVKQQEEKKQQCENKSQPSQDSKGPLPPPAKQKPPPEQPQEQVHPQPPPGPKPPKEQDPPTQSTFKDNLQKDTQRQGPAGAQQDGQQPCKSRDGPTILSGYGECATRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GG40</accession>
    <name>A0A9J7GG40_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein ZXDC isoform X5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Zxdc</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZXD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027284652.1">
        <property type="nucleotide sequence ID" value="XM_027428851.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297527.1">
        <property type="nucleotide sequence ID" value="XM_035441636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GG40"/>
    <dbReference type="GeneID" id="100771535"/>
    <dbReference type="KEGG" id="cge:100771535"/>
    <dbReference type="CTD" id="79364"/>
    <dbReference type="OrthoDB" id="6277246at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000543">
        <property type="entry name" value="Zinc finger protein 384 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000872">
        <property type="entry name" value="zinc finger X-linked protein ZXDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000257">
        <property type="entry name" value="ZXD family zinc finger C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000499">
        <property type="entry name" value="ZXD family zinc finger C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001192">
        <property type="entry name" value="ZXD family zinc finger C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF5">
        <property type="entry name" value="ZINC FINGER PROTEIN ZXDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="685"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="750"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027284652.1"/>
        </source>
    </evidence>
    <sequence length="898" mass="94745" checksum="C3F2915ECD174185" modified="2023-06-28" version="1">MPGRAGRLFSGGCGSDASAGPKMDIPAVLAAPVARGDQHGGGPSRLRRGTGPSLGAGPGRRRLLLLRGPEDGGPGPRQEEAPGPSPPPSEDGSDSFVVLLEVPRAADAHGQEEAEPGPCASPPEQVPAAAPGAALAGTVTIHNQDLLVRFDRGVFTLAAAPAPAAPSLHPATTAGPEPSSASVSRRGPVATSAGSPIYRCPEPQCALSFAKKHQLKVHLLTHGSLQGRRPFKCPLDGCGWAFTTSYKLKRHLQSHDKLRPFGCPVGGCGKKFTTVYNLKAHMKGHEQESLFKCEVCAERFPTHAKLNSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQELFSCSFPGCNKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHKRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSKKHLQDVGAPKSRCPVSSCNRLFTSKHSMKAHMVRQHSRHQDLVPHLEAPSSLTPSSELSSPGQSELTNIDLAALFSDTPANSGNSAPGSDEALNSGILTIDVTSVSSSLGGNLPSNNNSLGPMDPLVLVAHSDMPPSLDSPLVLGTSATVLQPGSFSTDDSQAMSTGAVGCLVALPVRNLGQDPPALTPSSNLAAPDAAPTSSGTAQETARVPDLLVPIKVEQDLPPVPDVVQGQEESHRPSQSMLSSSAEKPGAHKDSEFSAGTGSLYLESGGSARTDYRAIQLVKKKKQKGTGSDEGASESAHGKMKGSVVSPPHVHSGQHSCFCGNLMVPSGGLPTPAPAAGLQCVQIPVLQPVSLHLCKPLPLLGLTYQDDSSGEGGLPLALSPQRSAFHPYFTVDLPVYVLQEVLPASGGSAGLEAAQVPGSTINLQDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GHF4</accession>
    <name>A0A9J7GHF4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAUS augmin-like complex subunit 5 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Haus5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027287040.1">
        <property type="nucleotide sequence ID" value="XM_027431239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GHF4"/>
    <dbReference type="GeneID" id="100751456"/>
    <dbReference type="KEGG" id="cge:100751456"/>
    <dbReference type="CTD" id="23354"/>
    <dbReference type="OrthoDB" id="2019614at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029131">
        <property type="entry name" value="HAUS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026215">
        <property type="entry name" value="HAUS5_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14817">
        <property type="entry name" value="HAUS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02091">
        <property type="entry name" value="HAUSAUGMINL5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027287040.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="71089" checksum="4E17721B6F99E97E" modified="2023-06-28" version="1">MEDLRQKVRELSRWAAEEMEAPRAAVPGEPALRRMCLGQGADIWAYIVQHVRSQRSVKTVRGNLLWYGHQDNSKVRRKLELEATVARLRAESQKLDQSLELMDQETEAQDMTIAQTLQSLKETQHRTLLLQAKGRAVQRQQCGLQGPMKRLQNQLSHLQDMQRKAKVDVAFGPPVSAAPALEPGVLCDVQTACSLRTQFLQNLLIPQARGGSILPQDDDHFRSSHQQWLSSVETLLTNHPAGHILAALKYLAAEREKEIWSLCSGDGLKEEAPSSPQAPEPSSSRQALPPVVHLIQEGWQAIGALYTERNVLLEEHQALTGRLQSLVEEVVGRHAPGSSERKALLLGLKCSGRKAELTSLRAQCQELKNAVGSRKLLLRELQAKQQQILRWRQLVEETQERIRLLIKDNSVSKTRLSQGPEEVLALMQQKVVPTSEAVAPQSQELLHCLKKEAQHLPHIQLGPLLRYHAKGLKPLSKSLPSIQQLHPATPRSCSHILLSHTLGLPVGKAPELLLPKAASLRQDLLFLQDQRDLQRGNLHVKTSLPLGPSTQELLQIKASQEKEQKEDMGQTLKKLEDLVTQSLEQIPKLQWLVGDWWEQPGQATLSGEPCQGLSLPQWQLRWAQACRALQQPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GI67</accession>
    <name>A0A9J7GI67_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 40 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Tmem40</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027284972.1">
        <property type="nucleotide sequence ID" value="XM_027429171.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GI67"/>
    <dbReference type="GeneID" id="100769883"/>
    <dbReference type="KEGG" id="cge:100769883"/>
    <dbReference type="CTD" id="55287"/>
    <dbReference type="OrthoDB" id="9382530at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026181">
        <property type="entry name" value="TMEM40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16108">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16108:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15817">
        <property type="entry name" value="TMEM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027284972.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25742" checksum="127E4B945A9CF17A" modified="2023-06-28" version="1">MSPGTPGKEMEASGSSSQSEEASGIHRETENLNYQETEFHKQDGKARERCERDKSSSSSSSSSSSSSSSSSSSSSDSSDEDQHPRGPREHRRKPHRDSSPGADHGELEVLRDDLQLYGGDSGEMVLAGESGLRRRGSGSTGGEMEASQLRRLNIKKDDEFFHFVLLCFAIGALLVCYHYYADWFMSLGVGLLTFASLETIGIYFGLVYRIHSVLQGFIPLLQKFRLPGFRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GLS3</accession>
    <name>A0A9J7GLS3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aminopeptidase Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Laeverin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Lvrn</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294621.1">
        <property type="nucleotide sequence ID" value="XM_035438730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GLS3"/>
    <dbReference type="GeneID" id="100770836"/>
    <dbReference type="KEGG" id="cge:100770836"/>
    <dbReference type="CTD" id="206338"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000015">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000005">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF31">
        <property type="entry name" value="AMINOPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 24" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="22">
        <location>
            <begin position="102"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="22">
        <location>
            <begin position="270"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="20">
        <location>
            <begin position="379"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="21">
        <location>
            <begin position="684"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="18">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035294621.1"/>
        </source>
    </evidence>
    <sequence length="1031" mass="118064" checksum="7C0B98E03DF6994B" modified="2023-06-28" version="1">MSPPSSSGIYVSRGVALLLAGLTAAVLLVLVALAALYGNCARVQQHSPGVKDTELSPPGGQKQAPPTPTSEAASEPAVATTSKDWRPPSGPWEHLRLPLWLVPFHYDLELWPRLRPDDLSMPSLTFTGCVNITVRCTVATSRMLLHSFLLNYKRVEVWGPLALGTRNATAGRVPVDNVWFALEMQYMVLDLGQTLQPGSKYELDLCFSGQVLQHASEGLFLNFYIDQGEHSCQGPQCLLRAVCGIWCILPNFRALHFWNFSAGICQSIALIASQMEPTFARNVFPCFDEPALKATFNITIIHHPAYVALSNMPQLGQSERMDVNGSRWKVSTFHTTPRMPTYLVALAVCDFDHVSRTERGKEIRVWARKDDIANGNVDFAVNITGPIFSFLEDLFNISYPLPKTDIIALPTFDNRAMENWGLLIFDEAFLLLEPDDELTEKRAMVLSIISHEVGHQWFGNLVTMSWWNNIWLNEGFASYFELGIINYFYPKLPRNEIFFFNFLHGVLREDHALESRAVSTDMEIFTETREINELFDIYTYNKGACMARMLDSFLDQHLFVNALKSYLETFSYSNAEQDDLWRHFQMAIDEQNVIHLPTTVKNIMDSWTYQGGFPVVTLNVSTGIMKQEPFYLEKAENQILVSRNNTWIVPIFWMKNGITQPLVWLDKSNMVFPEMQLSDSDGDWVILNLNVTGYYRVNYDELGWKKLSQQLEKDPKAIPVIHRLQLVSDAFALSKNNYLEIETALDLTKYLAEEDEILVWFEVLINLINRNVISDVNNFAIYPLLKKYLLKRINSIWNTYSAIIRENVAALQDNYLALLSLEKFFETACWLGLEDCLQLSKELFRKWMADPETEIPHPIQRVVLCNGIALGSDKEWDFLLRFYINTTKEEEEEERRVHLIYALSCSKEPWTLNRFMEYAITVSPSPFNETNIIEAVATSEVGCYVAKEFLINNWLAVIERYGPQSLDALVWVIGRTVSTDLQVMELQRFLGNVLEEHQRTAAHAKLQAIKTENLKNKKRIARMAEWLRKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMP9</accession>
    <name>A0A9J7GMP9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lymphocyte antigen 6K-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC113834494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035294692.1">
        <property type="nucleotide sequence ID" value="XM_035438801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GMP9"/>
    <dbReference type="GeneID" id="113834494"/>
    <dbReference type="KEGG" id="cge:113834494"/>
    <dbReference type="OrthoDB" id="9617216at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23550">
        <property type="entry name" value="TFP_LU_ECD_Ly6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052874">
        <property type="entry name" value="Sperm-ZP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15049">
        <property type="entry name" value="GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED MOLECULE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15049:SF1">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039930328" evidence="2">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="3">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035294692.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18557" checksum="23FA23477F86D280" modified="2023-06-28" version="1">MEMLVLLALLTTMGLPLAQTKDRTKREEKFSCHVCELENSFNCTNPTECPSDKQFCVMAAIRLFERFYLTSKQCSKSCPVPPYVRQEKFVPPEPKPFLPQKPLPFMYTRCCKWNLCNEGGPSISVFKEQPGKASERRHRYTELFLTGFIVLSASAVTDLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GN67</accession>
    <name>A0A9J7GN67_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 120-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113838906</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027290215.1">
        <property type="nucleotide sequence ID" value="XM_027434414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GN67"/>
    <dbReference type="GeneID" id="113838906"/>
    <dbReference type="KEGG" id="cge:113838906"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000240">
        <property type="entry name" value="Zinc finger protein 250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027290215.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38564" checksum="88805C577EBE3C8D" modified="2023-06-28" version="1">MTYDDVHIDFTWEEWTLLDTSQKNLYIDVILDTYRNLTDIGYCWEDNTIEEHCASSKRHERHEGRQTGEKPYVYTQCLKAFACYSHLQMHKRTHSGEKPYECNLCGKDFAHYSYLKTHKRTHTGEKPHECNHCGQAFSRHSHLQTHERRHTGEKPYECNQCGKAFAQQRTLQMHKRTHTGEKPYECNQCGQAFSRHSHLQSHKRRHTGEKPYECYQCGKAFSHLSSLHVHKRTHTREKPYECNQCGKAFARCSQLQIHKRTHTGEKPYECNQCGKAFSQNGSLQIHKRRHTGEKPYECNQCGKAFSHHGSLQMHKRRHTGEKPYECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GR28</accession>
    <name>A0A9J7GR28_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 809-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113838792</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027290113.2">
        <property type="nucleotide sequence ID" value="XM_027434312.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GR28"/>
    <dbReference type="GeneID" id="113838792"/>
    <dbReference type="KEGG" id="cge:113838792"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004135">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000003">
        <property type="entry name" value="Zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF390">
        <property type="entry name" value="ZINC FINGER PROTEIN 37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027290113.2"/>
        </source>
    </evidence>
    <sequence length="444" mass="51306" checksum="39F57B070743B8AD" modified="2023-06-28" version="1">MVESLAAPGRLGPGATGSHQAGAALQLRRFSTAQHTAALISGLQSLGGGLVSFEDIAVVFTWEEWQELDAAQRTLYRDVMLENYSNLVFLELCTVKPKLIFNLEHGCGPWSLAEASVWSPPNVHKVSDLIDTSKENPEIHLGQLEITNQKTPDEDTTRAKLKTQQEVYKGTKSHHRGACHQKLQKSKSQTLHRDEKLYDCKDCGKTFCTNSTLIKHRRRTHNIEKRFECTKCGKSYHWKSDLTSHQKTHWQERTYICKGCGKAFFRKSHLNAHERTHTGEKPHKCTECNKAFHYKSDLTRHKKIHLGEKPYKCEECNKGFSRKSKLDIHQKTLTGEKPYECTDCGKTFFHKSQLTAHRIVHSSENFYECKECNKSFHWKCQLTAHQKRHTGRSFMNEECRKILHESEVTGLWRNQAAEEPYEYEEFKEEFYIEPDLTVLYQGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUE7</accession>
    <name>A0A9J7GUE7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cadherin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Cdh13</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035298600.1">
        <property type="nucleotide sequence ID" value="XM_035442709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751312"/>
    <dbReference type="KEGG" id="cge:100751312"/>
    <dbReference type="CTD" id="1012"/>
    <dbReference type="OrthoDB" id="9933746at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000095">
        <property type="entry name" value="Cadherin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000022">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000031">
        <property type="entry name" value="Cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000148">
        <property type="entry name" value="cadherin-13 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014868">
        <property type="entry name" value="Cadherin_pro_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF80">
        <property type="entry name" value="CADHERIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08758">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01055">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="297"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="415"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="529"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="635"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035298600.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="83782" checksum="ED32081A036C2999" modified="2023-06-28" version="1">MQTPPGASSSRARCSXELRSPCAFCCPRAKQPNCTAMWTNYPLQEHPSKSSPWMPGMDPLSPSTLQVLLVTSADDLDCTPGFQQKVLHIQQPAEFIEDQPVLNLTFSDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVGRTLFVHARTLHAEDMAELVIVGGKEIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPEGSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDRETIATYQLFVETTDVSGKTLEGPVPLEVIVIDQNDNRPIFREGPYVGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIVIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTKWENISVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVHNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHPNTDPFKFEIHKQSVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMANITDLRVQVCSCKNSKVDCNAAETLHLSLSLLLFFSLLSLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GXJ6</accession>
    <name>A0A9J7GXJ6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cathepsin E</fullName>
            <ecNumber evidence="5">3.4.23.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Ctse</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Similar to cathepsin D, but slightly broader specificity.</text>
            <dbReference type="EC" id="3.4.23.34"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.34" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035301585.1">
        <property type="nucleotide sequence ID" value="XM_035445694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GXJ6"/>
    <dbReference type="GeneID" id="100757212"/>
    <dbReference type="KEGG" id="cge:100757212"/>
    <dbReference type="CTD" id="1510"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019886">
        <property type="term" value="P:antigen processing and presentation of exogenous peptide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000006">
        <property type="entry name" value="Cathepsin E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF26">
        <property type="entry name" value="CATHEPSIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039925373" description="Cathepsin E" evidence="19">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="20">
        <location>
            <begin position="78"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035301585.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="42758" checksum="F90C2043EFC868BE" modified="2023-06-28" version="1">MKSLLALLLVLLDLGQAYGAIHRVPLRKHQSIRKKLRARGKLSDFWKSQNLDMIQFSESCKMDQSTNEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHPVFHPSQSSTYEEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVDGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPIFSVYMSSDPQGGSGSELTFGGFDPSHFSGNLNWIPVTKQGYWQIALDGVQVGDTVMFCSEGCQAIVDTGTSLITGPSHKIKQLQEAIGATPMDGEYAVDCANLNTMPNVAFILNGVSYTLSPTAYILPDLVDGMQFCGSGFQGLDIQPPSGPLWILGDVFIRQFYAVFDRGNNQVGLAPAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H004</accession>
    <name>A0A9J7H004_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: LBH domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lbhd2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035301803.1">
        <property type="nucleotide sequence ID" value="XM_035445912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113835825"/>
    <dbReference type="KEGG" id="cge:113835825"/>
    <dbReference type="CTD" id="107984640"/>
    <dbReference type="OrthoDB" id="9421103at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038990">
        <property type="entry name" value="LBH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042945">
        <property type="entry name" value="LBH_dom_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14987:SF3">
        <property type="entry name" value="LBH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14987">
        <property type="entry name" value="PROTEIN LBH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15317">
        <property type="entry name" value="Lbh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035301803.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="16280" checksum="B2BCB158E8106AA3" modified="2023-06-28" version="1">MTMFRQAVSFPLAPSIGSSMSTLQSESPVEGTGGPEGKLAMWREEAKDPAGKRPERKNAGFQAAVGVREKGPRLCQRLPSIVVEPTDVGTVESGELRWPPEGTQRGTPQIQAAAVTSSSPPGTLGKASDHDGMEGXSSGHQAFPGPVTDKGMAGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H0T6</accession>
    <name>A0A9J7H0T6_CRIGR</name>
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            <fullName evidence="18">Neurexin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Neurexin I-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Neurexin-1-alpha</fullName>
        </alternativeName>
    </protein>
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        <name evidence="28" type="primary">Nrxn1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Presynaptic cell membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301075.1">
        <property type="nucleotide sequence ID" value="XM_035445184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761660"/>
    <dbReference type="CTD" id="9378"/>
    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032940">
        <property type="term" value="P:secretion by cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000029">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000001">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000003">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000004">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000005">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000007">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000014">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF51">
        <property type="entry name" value="NEUREXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 21" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 24" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039905235" description="Neurexin-1" evidence="24">
        <location>
            <begin position="26"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1477"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="25">
        <location>
            <begin position="30"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="219"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="25">
        <location>
            <begin position="320"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="25">
        <location>
            <begin position="524"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="720"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="25">
        <location>
            <begin position="762"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="25">
        <location>
            <begin position="949"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="26">
        <location>
            <begin position="1127"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="25">
        <location>
            <begin position="1170"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1433"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1518"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_035301075.1"/>
        </source>
    </evidence>
    <sequence length="1551" mass="170469" checksum="8AE42A792E876DED" modified="2023-06-28" version="1">MGSALVQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDQAEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDSGEVKLDDEPPNSGGGSPCEAGDEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQGKACPTPVSVYLFYVFIFYDHDQGKYSCINTEKPLNQKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQSTAGVKPSCSRETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPVSQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H131</accession>
    <name>A0A9J7H131_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Nuclear receptor coactivator 6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8 9 10" type="primary">Ncoa6</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4 5 6">17A/GY</strain>
            <tissue evidence="4 5 6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003501176.1">
        <property type="nucleotide sequence ID" value="XM_003501128.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640015.1">
        <property type="nucleotide sequence ID" value="XM_007641825.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277190.1">
        <property type="nucleotide sequence ID" value="XM_027421389.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277191.1">
        <property type="nucleotide sequence ID" value="XM_027421390.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277193.1">
        <property type="nucleotide sequence ID" value="XM_027421392.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302631.1">
        <property type="nucleotide sequence ID" value="XM_035446740.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302632.1">
        <property type="nucleotide sequence ID" value="XM_035446741.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302633.1">
        <property type="nucleotide sequence ID" value="XM_035446742.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302634.1">
        <property type="nucleotide sequence ID" value="XM_035446743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751846"/>
    <dbReference type="KEGG" id="cge:100751846"/>
    <dbReference type="CTD" id="23054"/>
    <dbReference type="OMA" id="RDYPFES"/>
    <dbReference type="OrthoDB" id="5967287at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026638">
        <property type="entry name" value="NCOA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032715">
        <property type="entry name" value="NCOA6_TRADD-N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15690">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15690:SF0">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13820">
        <property type="entry name" value="NCOA6_TRADD-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear receptor coactivator 6 TRADD-N" evidence="2">
        <location>
            <begin position="47"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1451"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1950"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1796"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1851"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1999"/>
            <end position="2008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027277190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027277191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027277193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035302631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035302632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035302633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035302634.1"/>
        </source>
    </evidence>
    <sequence length="2060" mass="219110" checksum="C7A78B0F2906A5E2" modified="2023-06-28" version="1">MVLDDLPNFEDIYTSLCSSTMEDSEVDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALGQNRSQDVRMNGPMASGNSVRMEAGFPMASGPGLIRMASPATVMMPQGGNMSSSMMAPGPSPELQPRTPRPASHSDAMDPLLSGLHIQQQSHPSGSLPPAHHPMQPVPGNRQMNPANFPQLQQQQQQQQQQQQQQQQQLQTRPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPSPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPIPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATTPGNSGALQLQANQNVQHGGGQGAGPPQNQMQVSHGPPNMMQSSLMGIHGNINNQQAGSSGVPQVTLGNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPQNQNLGPSPQRMTPPKQMLPQQGQQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLSQQGPVNSSPSQVMGIQGQVLRPPGPSPHMAQQHGDPATTANNDVNLSQMLPDVSMQQTNMVPPHVQSMQGNSASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNCQQDLNTQDNRPAGLEEADQQSLPGEQGINLDNTGPKLPEFSNRPPGYPTQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQQQPPPPPSQPQSQQHQQQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRMPVQQSGNVPVMVSLQGPASVPPSPDKQRIPMSVNTPLGSNSRKMVYQENPQNSSSSPLAELSSLPEASGNEVPSVSGGPNNMPSHLVVSQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTINNPPNFAAPQAHKLDSVVVNSGKQSNPGTTKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQPSTTLLQNMELPRNVLVSPTPIANPTLSGSFPNNSGLNPQNPSVPVPVPAVGAVLEDNKESLNVPQDNDCQNSQGRKEQVNVELKVVPIQEAKMVVPEDQSKKDGQPLDANKLPSVEENKNLMSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLEVAPPVVSGEDLKKASVIPTLQDPPSKEPSNSLNLPHSNEPCSTLAHPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAALPTNLHSALMSTVVTMPNVGNKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVAPNVPSSSPAPNIQTGRPLVLSSRATPVQLPSPPCTSSPVVAPNSSIQQVKELNPDEASPQMNTSADQSTLLSSQSTTVVSPLLTNSPGSSANRRSPVSSTKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGPGLETTTPGLMGTEQCSTELDSKTPTPSAPTLLKMTSSPMGPSSTSTGPILPGGALPTSVRSIVTTLVPSELISTAPTTKGNHGGVASEPLAGGLVEEKVGPHPELLPSIAPSQTLVPKETPATALQGPVARPELEANAVIVSGQSSEPKEIVEKSKTPSRRNSRTEEPTVASESVENGHRKRSSRPASASSSTKDITGAVQSKRRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H3L8</accession>
    <name>A0A9J7H3L8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Casein kinase II subunit alpha</fullName>
            <shortName evidence="9">CK II alpha</shortName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Csnk2a1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="RefSeq" id="XP_035302736.1">
        <property type="nucleotide sequence ID" value="XM_035446845.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317721.1">
        <property type="nucleotide sequence ID" value="XM_035461830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H3L8"/>
    <dbReference type="GeneID" id="100759365"/>
    <dbReference type="KEGG" id="cge:100759365"/>
    <dbReference type="CTD" id="1457"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF16">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035302736.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="46309" checksum="B5A0FB10FFEF2B13" modified="2023-06-28" version="1">MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSSNMPGGSTPVSSATMMSGISSVPTPSPLGPLAGSPVIAAANPLGCLFQLPLVPNSNDPHPSPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4L3</accession>
    <name>A0A9J7H4L3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Single-stranded DNA cytosine deaminase</fullName>
            <ecNumber evidence="13">3.5.4.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Activation-induced cytidine deaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Aicda</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50948"/>
            <dbReference type="Rhea" id="RHEA-COMP:12846"/>
            <dbReference type="Rhea" id="RHEA-COMP:12847"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:133902"/>
            <dbReference type="EC" id="3.5.4.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.38" evidence="13"/>
    <dbReference type="RefSeq" id="XP_035304910.1">
        <property type="nucleotide sequence ID" value="XM_035449019.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316213.1">
        <property type="nucleotide sequence ID" value="XM_035460322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4L3"/>
    <dbReference type="GeneID" id="100689250"/>
    <dbReference type="KEGG" id="cge:100689250"/>
    <dbReference type="CTD" id="57379"/>
    <dbReference type="OrthoDB" id="8676111at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016554">
        <property type="term" value="P:cytidine to uridine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070383">
        <property type="term" value="P:DNA cytosine deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045869">
        <property type="term" value="P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016445">
        <property type="term" value="P:somatic diversification of immunoglobulins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000022">
        <property type="entry name" value="Single-stranded DNA cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050610">
        <property type="entry name" value="APOBEC_Cyt_Deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13857">
        <property type="entry name" value="MRNA EDITING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13857:SF10">
        <property type="entry name" value="SINGLE-STRANDED DNA CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18778">
        <property type="entry name" value="NAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035304910.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22781" checksum="BC2EFD90294FC6A3" modified="2023-06-28" version="1">LIHSLLMKQKKFLYHFKNVRWAKGRHETYLCYVVKRRDSATSFSLDFGHLRNKSGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVAEFLRWNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIGIMTFKENHERTFKAWEGLHENSVRLTRQLRRILLPLYEVDDLRDAFRILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HB04</accession>
    <name>A0A9J7HB04_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Relaxin-3 receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">G-protein coupled receptor 100</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Insulin-like peptide INSL5 receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Relaxin family peptide receptor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Rxfp4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">High affinity receptor for INSL5. Also acts as a receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035307220.1">
        <property type="nucleotide sequence ID" value="XM_035451329.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312059.1">
        <property type="nucleotide sequence ID" value="XM_035456168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764058"/>
    <dbReference type="KEGG" id="cge:100764058"/>
    <dbReference type="CTD" id="339403"/>
    <dbReference type="OrthoDB" id="9936726at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15925">
        <property type="entry name" value="7tmA_RNL3R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000273">
        <property type="entry name" value="Relaxin family peptide/INSL5 receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000248">
        <property type="entry name" value="ATII_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF951">
        <property type="entry name" value="RELAXIN FAMILY PEPTIDE_INSL5 RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00241">
        <property type="entry name" value="ANGIOTENSINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="56"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00084004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035307220.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49219" checksum="294764E409665E81" modified="2023-06-28" version="1">MATSNSSASLSTLFWANGSGDSVLSTDGAAMPAQFLALRIMVALAYGLVGIIGLLGNLAVLWVLGNCAQRAPGPPSDTFVFSLALADLGLALTLPFWATESALDFHWPFGSVLCKIVLTTTVLSIYASIFLITALSVARYWVVAMAVGPGSHLSVFWARVVTLAVWVAAALMTVPTAIFGAEGELWGVHLCLLRFPSRYWLGAYQLQRVILAFIVPLGIITTSYLLLLAFLQRQQRCRPQQWQDSRVVARSVRILVASFVLCWFPNHVVTLWGVLVKFDLVPWDSTFYTIHTYVFPVTTCLAHSNSCLNPVLYCLLRRKPRQVLVSSLRDLWSRLWPQSKACVEQVALKEVGGRXVASTQQRPFHXHAQTQRHLDEGCNLDTPFSEIHQGQNPQIVGRRTQKLELKQKVGEAKLVSRDGKKKLRIKLWFIHDCLDLSCQYSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HBD3</accession>
    <name>A0A9J7HBD3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Placenta-specific protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Plac9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035308965.1">
        <property type="nucleotide sequence ID" value="XM_035453074.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312294.1">
        <property type="nucleotide sequence ID" value="XM_035456403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HBD3"/>
    <dbReference type="GeneID" id="100754984"/>
    <dbReference type="KEGG" id="cge:100754984"/>
    <dbReference type="CTD" id="219348"/>
    <dbReference type="OrthoDB" id="9937406at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027941">
        <property type="entry name" value="PLAC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37355">
        <property type="entry name" value="PLACENTA-SPECIFIC PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37355:SF1">
        <property type="entry name" value="PLACENTA-SPECIFIC PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15205">
        <property type="entry name" value="PLAC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039899476" evidence="2">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035308965.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23375" checksum="4377682265F9646D" modified="2023-06-28" version="1">MQPLLCALAGLALLGVEAGEWGQGPRDTPGRRAAESSSSSREDIAWSPGCDRHVAVQGRLDIMEETVEKTVEHLEAEVTGLLGLLEELASNLPPGPFSPEPDLLGGGEWLRRQRDTCWACHLGPLAAGGARTHRGCYAAVPGTELVVAHHPIGVLGPGILSELRPSPAPVLTPVFWYCCPKRLGSWREDIGGHSILSCSLRAHPLLQITSDHQGAVEPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HC46</accession>
    <name>A0A9J7HC46_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC113838583</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035309509.1">
        <property type="nucleotide sequence ID" value="XM_035453618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HC46"/>
    <dbReference type="GeneID" id="113838583"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035309509.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21607" checksum="B655056727C63CF2" modified="2023-06-28" version="1">MSEYKLMVVGADGVGKSALTIQLIQNHFVDVYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAMNNTKSFEAIHHYREQIKRAKDSEDMPMVLVGNKCDLPSRTVDTNQAQDLAGSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGRVKNKKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCE6</accession>
    <name>A0A9J7HCE6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vitamin D-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Gc-globulin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Group-specific component</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Gc</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035309388.1">
        <property type="nucleotide sequence ID" value="XM_035453497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCE6"/>
    <dbReference type="GeneID" id="100763450"/>
    <dbReference type="KEGG" id="cge:100763450"/>
    <dbReference type="CTD" id="2638"/>
    <dbReference type="OrthoDB" id="9874779at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005499">
        <property type="term" value="F:vitamin D binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00015">
        <property type="entry name" value="ALBUMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.10:FF:000007">
        <property type="entry name" value="Vitamin D-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.10:FF:000010">
        <property type="entry name" value="Vitamin D-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000264">
        <property type="entry name" value="ALB/AFP/VDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020858">
        <property type="entry name" value="Serum_albumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020857">
        <property type="entry name" value="Serum_albumin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014760">
        <property type="entry name" value="Serum_albumin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000213">
        <property type="entry name" value="VitD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015247">
        <property type="entry name" value="VitD-bind_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11385">
        <property type="entry name" value="SERUM ALBUMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11385:SF11">
        <property type="entry name" value="VITAMIN D-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00273">
        <property type="entry name" value="Serum_albumin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09164">
        <property type="entry name" value="VitD-bind_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00802">
        <property type="entry name" value="SERUMALBUMIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00804">
        <property type="entry name" value="VITAMNDBNDNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00103">
        <property type="entry name" value="ALBUMIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48552">
        <property type="entry name" value="Serum albumin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00212">
        <property type="entry name" value="ALBUMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51438">
        <property type="entry name" value="ALBUMIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0848">Vitamin D</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039945366" description="Vitamin D-binding protein" evidence="15">
        <location>
            <begin position="17"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Albumin" evidence="16">
        <location>
            <begin position="16"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Albumin" evidence="16">
        <location>
            <begin position="209"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035309388.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53179" checksum="D81E96020E204A43" modified="2023-06-28" version="1">MKRVAALLLALALGHALERGRDYEKDKVCKELAMLGKDDFRSLSLILYSRKFPSGTFQQVSQLVKEVVSLTEECCAEGADPNCYDTRTSELSIKSCESDAPFPVHPGTPECCTQEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKGFADEFLYEYSSNYGQAPLSLLVGYTKSYLSMVGSCCTSASPTVCFLKERLQIKHLSLLTIMSNRVCSQYAVYGKEKSRLSHLIKLAQKVPTANLEDVMPLAEDLTQILSRCCESTSEDCMAKELPEHTLKICDNLSTKNSKFEECCQEKTPMDIFMCTYFMPAAEPLQLPAIKLPTETDLCGQSTTQAMDQYTFELSRRTRVPEVFLSKVLETTLKSLSECCDAQDSKACFSTQSPILKKQLTSFIERGQELCADYSENTFTEYKKKLAERLRTKTPNASPGDLEDMVDKHSDFASKCCSINSPPLYCSSQIDAEMRDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J6V3</accession>
    <name>A0A9J7J6V3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Transmembrane protein 106C isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13" type="primary">Tmem106c</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10 11 12">17A/GY</strain>
            <tissue evidence="10 11 12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM106 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007651493.1">
        <property type="nucleotide sequence ID" value="XM_007653303.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651494.1">
        <property type="nucleotide sequence ID" value="XM_007653304.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651495.1">
        <property type="nucleotide sequence ID" value="XM_007653305.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651496.1">
        <property type="nucleotide sequence ID" value="XM_007653306.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252227.1">
        <property type="nucleotide sequence ID" value="XM_027396426.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252228.1">
        <property type="nucleotide sequence ID" value="XM_027396427.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252229.1">
        <property type="nucleotide sequence ID" value="XM_027396428.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252230.1">
        <property type="nucleotide sequence ID" value="XM_027396429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J6V3"/>
    <dbReference type="GeneID" id="100755506"/>
    <dbReference type="KEGG" id="cge:100755506"/>
    <dbReference type="CTD" id="79022"/>
    <dbReference type="OrthoDB" id="508875at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009790">
        <property type="entry name" value="TMEM106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048509">
        <property type="entry name" value="TMEM106_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048511">
        <property type="entry name" value="TMEM106_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07092">
        <property type="entry name" value="TMEM106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21002">
        <property type="entry name" value="TMEM106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 C-terminal" evidence="7">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027252227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027252228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027252229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027252230.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28808" checksum="940664A34CEC9645" modified="2023-06-28" version="1">MGSQHSSSARTFCQRRKDDNLEDLEAEREQEEAIAQFPYVEFTGRNSITCHTCQGAGYVPAEQLNELVALIPHSDQRLRPQRTKQYVLLSVLLCLLASGLVFFFLFPHSVLVDDNGIKVVKVTFNKQDSLVMLDVMATLKIRNSNFYPVAVTNLFSQVQYMKAVVGTYMTTNVSLIPPRSEHLVNFTVKAKLHLHGTCHPGAQHRDLHEDFCEDFIHWPHVPEHLGDTTLCGLWGEFHSCLEPAFSSPLAVPVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JEJ0</accession>
    <name>A0A9J7JEJ0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase Topors</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RING-type E3 ubiquitin transferase Topors</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">SUMO1-protein E3 ligase Topors</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Topoisomerase I-binding RING finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Topoisomerase I-binding arginine/serine-rich protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Tumor suppressor p53-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Topors</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_003506016.2">
        <property type="nucleotide sequence ID" value="XM_003505968.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259175.1">
        <property type="nucleotide sequence ID" value="XM_027403374.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JEJ0"/>
    <dbReference type="GeneID" id="100765733"/>
    <dbReference type="KEGG" id="cge:100765733"/>
    <dbReference type="CTD" id="10210"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000136">
        <property type="entry name" value="E3 ubiquitin-protein ligase Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058745">
        <property type="entry name" value="PWI_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26084">
        <property type="entry name" value="PWI_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="499"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="716"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="615"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="773"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="818"/>
            <end position="841"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="855"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="881"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071236"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00076856"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076940"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079184"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082108"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027259175.1"/>
        </source>
    </evidence>
    <sequence length="1041" mass="118222" checksum="069DCC18606B7570" modified="2023-06-28" version="1">MGSQPPPPGSPLSREEGEAPPLAPAEEGRRRSRRVRLRGSCRHRPSLLNRRELASSGPAGPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQNVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFSCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRAPTTYGSFTVPPEVRRFRYRTTMTRERNAPFYPASSTTTRRTTAPPDSGVLFEGLGISAARPRDVEIPQFMRQMALRGTASADERSLRKIQEQDIINFRRTLYRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSHSDSSVITISPDEAETQELDVNVSTVRQAPWDDETPGPSYSSSEQVHVGMSSLLNSSDSSDEELVPTGATSQVQEEQTNDDLNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSELGSYEKVETVKTQEQEQSYSSDDSDVCQCSSPRSLLGKDEQVSKSPCDSDRRIKSKKEEKRSTSSSTPRDSSSTRGDRVYSPYNHRHRKRGRSRSSDSHSQSRSGHDQRNHRKHHGKKRMKNKQSRSRESSSRPRARRDKKRSRTRESSWSRRSQTLSLSSGSSSRSRSRSSDHDKRRSRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRKRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERHRSRSLSSNRSRTTSTGPDRVRNEKPGGKRKYKTRHLEGTNEVGQPSRDCATKVKDSHYQKSSKLDGNYKNESDSFSDSRSSDRETKHKKRKRRARSLSVEIVYEGKTIDTTKHHKKKKKKHKKKHKKHHGDNTSRSPVIITIDSDSDKDSVLKARVDPSNSKLPQPVHSEVLTPSLEEAFETKDVVTIEDELGVLDKECDVTALADDLNTSQTLDNSVPPAVSVEQTLDVREESTFASDLESQSSNTSIQSEPSGPLPSPRTSLLSVSLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JEJ3</accession>
    <name>A0A9J7JEJ3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Pappalysin-1</fullName>
            <ecNumber evidence="18">3.4.24.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Insulin-like growth factor-dependent IGF-binding protein 4 protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Pregnancy-associated plasma protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">Pappa</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.</text>
            <dbReference type="EC" id="3.4.24.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.79" evidence="18"/>
    <dbReference type="RefSeq" id="XP_027256063.1">
        <property type="nucleotide sequence ID" value="XM_027400262.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100764393"/>
    <dbReference type="KEGG" id="cge:100764393"/>
    <dbReference type="CTD" id="5069"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000045">
        <property type="entry name" value="Pappalysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000057">
        <property type="entry name" value="Pappalysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000061">
        <property type="entry name" value="Pappalysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000068">
        <property type="entry name" value="Pappalysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000097">
        <property type="entry name" value="Pappalysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000026">
        <property type="entry name" value="Pappalysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043543">
        <property type="entry name" value="PAPPA/PAPPA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058897">
        <property type="entry name" value="PAPPA_SD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130">
        <property type="entry name" value="LAMGL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130:SF2">
        <property type="entry name" value="PAPPALYSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25900">
        <property type="entry name" value="PAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 24" id="KW-0732">Signal</keyword>
    <keyword evidence="5 22" id="KW-0768">Sushi</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039955301" description="Pappalysin-1" evidence="24">
        <location>
            <begin position="23"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="25">
        <location>
            <begin position="1280"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="25">
        <location>
            <begin position="1410"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="1412"/>
            <end position="1455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027256063.1"/>
        </source>
    </evidence>
    <sequence length="1624" mass="181308" checksum="87548B66F25875C1" modified="2023-06-28" version="1">MRLWSWVLRLGLLSAALGCGLAERPRRARRDPRAVRXPRPAAGPATCATRAARGRRASPPPPPGGAWEAVRVPRRRQQRAARGAEEPSPPSRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYDKCSYTSRDRGWVVGIHTISDQGNRDPRYFFSLKTDRARKVTTIDAHRSYLPGQWVYLAATYDGRLMKLYMNGAQVATSGEQVGGIFSPLTQKCKVLMLGGSAQNHNFRGYIEHFSLWKVARTQREILSDMETHGLHAPLPQLLLQENWDNVKRTWSPMKDGNSPRVEFSNAHNFLLDTSLEPPLCGQTLCDNTEVISSYNQLPSFRRPKVVRYRVVNIYDDDHKDPTVSQQQIDFQHQQLAEAFQHYNISWELEVLKINSSSLRHRLILANCDISKIGDEKCDPECNHTLTGHDGGDCRQLRYPAFTKKQQNGVCDMDCNYERFNFDGGECCDPDITDVTKTCFDPDSPHRAYLDINELKNILRLDGSTHLNIFFANSSEEELAGVATWPWDKEALMHLGGIVLNPSFYGIPGHTHTMIHEIGHSLGLYHIFRGISEIQSCSDPCMETEPSFETGDLCNDTNPAPKHKFCGDPGPGNDTCGFHSFFDTPYNNFMSYADDDCTDSFTPNQVSRMHCYLDLIYQSWQPSRKPAPVALAPQVVGHTTDSVMLEWFPPIDGHFFERELGSACDLCLEGRILVQYAFNASSPMPCGPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFQYPLVPESLTIWVTFVSIDWDSSGAVNDIKLLTVGGKNISLGPQNIFCDIPLTIRLRDVGEEVYGIQIYTLDEHLEIDAAMLTSTADSPLCLECKPLQYKVLRDPPLREDIASLLHLNRRFIDMDLKLGSVYQYQIITISGTEESEPSPAAIYTHGSGYCGDGIIQKGQGEECDDRNKINGDGCSLFCQQEVSFNCIDEPSRCYFHDGDGMCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVVIGQPAASQVCRTKVIDLSEGISQHAWYPCTINYPYYQLPQTTFWLQTYFSQPMVAAAVIIHLVTDGTYYGDQKQETISVQLLDTKEQSHDLGLHVLSCRNNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSPAEQSCVHFACEATDCPELAVENASLNCSSSQHYHGAQCTVSCLTGYVLQIQRDDELIKSQVGPSITVTCTEGKWNKQVTCEPVDCGVPDQHHVYAASFSCPEGTTFGKRCSFQCRHPAQLKGNNSILTCMEDGLWSFPEALCELMCLAPPPVPNADLQTVRCRESKHKVGSFCKYKCKPGYHVPSSSRKSKKRAFKTQCTQDGSWQAGTCVPVTCDPPPPKFHGLYQCTNGFQFNSECRIKCEDSEGSQGRGNNIIHCRKDGTWSGSFHVCREMQGQCLAPNQLNSNLKLQCPDGYAIGSECATSCLDHNSESIVLPVNVTVRDIPHWMNPTRVERIVCTAGLQWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQDDCACRDPEAQEHSRKDLRGYSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JHB1</accession>
    <name>A0A9J7JHB1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Nol12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with KIAA1191.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007649112.1">
        <property type="nucleotide sequence ID" value="XM_007650922.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259773.1">
        <property type="nucleotide sequence ID" value="XM_027403972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JHB1"/>
    <dbReference type="GeneID" id="100752251"/>
    <dbReference type="KEGG" id="cge:100752251"/>
    <dbReference type="CTD" id="79159"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027259773.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28119" checksum="95B66A6676413253" modified="2023-06-28" version="1">MSTQGTLPAPPLDVPDQAGWCRPLSTRRFRPAQSCALDHPNPARSMVPAHSQLLVVVDKREYLTGFHKRKVERKKAAIEEIKQRLKQEQKKLREERHQEYLKMLAEREEALEEADELERLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLPLPEQGDLDGSQEEVSCMEKPTKALPRKSKDPLLSQRISSLTATLHAHSRKKVKRKHPRRAQDSTKKPPSATRTSKTQRRRRMTGKARHSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JJF6</accession>
    <name>A0A9J7JJF6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100760660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003514363.1">
        <property type="nucleotide sequence ID" value="XM_003514315.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262616.1">
        <property type="nucleotide sequence ID" value="XM_027406815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JJF6"/>
    <dbReference type="GeneID" id="100760660"/>
    <dbReference type="KEGG" id="cge:100760660"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15936">
        <property type="entry name" value="7tmA_OR4D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027262616.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34470" checksum="3492B299AE8941A7" modified="2023-06-28" version="1">MEQSNYSRVKEFVFEGLTQSQELSLVLFLFLFLVYTATVLGNLLIMVTVTWESRLHTPMYFLLRNLSVLDICFSSITAPKVLVDLLSIRKTISFNGCFTQMFFFHLLGGADIFSLSVMAFDRYMAISKPLHYVTIMSKGRCTALIVASWVGGFVHSIVQISLLLPLPFCGPNVVDGFYCDVPQVLKLACTSTFALEVLMISNNGLISTLWFVFLLVSYTVIMTMLRSHTGEGRRKAISTCTSHITVVTLHFVPCIYVYARPFTALPMDRAVSITFTVIIPVLNPMIYTLRNQEMKSAMKKLRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JNL7</accession>
    <name>A0A9J7JNL7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Disintegrin and metalloproteinase domain-containing protein 21-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100758249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272491.1">
        <property type="nucleotide sequence ID" value="XM_027416690.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JNL7"/>
    <dbReference type="GeneID" id="100758249"/>
    <dbReference type="KEGG" id="cge:100758249"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990913">
        <property type="term" value="C:sperm head plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF140">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="215"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="10">
        <location>
            <begin position="418"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="644"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027272491.1"/>
        </source>
    </evidence>
    <sequence length="755" mass="84999" checksum="8104153695BCF355" modified="2023-06-28" version="1">MVLSLNWGMRLVGRSVTLRAPLLLAALWVLLLVPSQCFQGRPTWRYVSSEVVTPRKVTYHGKGFQAPGRLSYSLRFRGQRHIIHMRRKTLFWPRHLLLTTQDDQGALQMDFPFFPVDCYYVGFLEEIPQSTVTLDTCSGGLNGVVMFDDLAYEIKPLSDSHRFEHVISQVVADSGAVGPMNKGKPMEHNTDPVFSGTNSSVAPRISSRDYASHPAAIKGHFQATSEVLKKARYNVSRCAHYLFSVASLMDTYFNSIHVRYYVILLTVYTWRNPFRHDYNLQNGEALRYYKSNFFNNIRPDTSNIINEYGPDDHVVVPIANSICTGDALNPVGQNDRYYVYVSVVVTTRVGIIVGLKFDDEKHCFCQRRSTCVMFKNPGLTDAFSNCSISELNKIVNTPGQASCLFYDHHFYYNRSYTYSVCGNSVIDEGEQCDCGSNKACYVNPCCGNDCKYSRDSICDEQLCCANCTYSPPGTLCRSVQNVCDLPEYCSGSAVTCPNDFYLQDGTPCSEEGYCYAGNCTDRSVHCKEIFGAGVQAGSEKCYEINKEKFRFGHCYRSPESLEFTACSDQDKMCGRLQCTNVTYLPRLQDHVSFHQSDISGFSCFGLDEHRGTGRTDVGHVRYGTQCSKSNFCDRGSCNGSVTGLNYDCTPEKCNFRGVCNNLRHCHCHLGWEPPHCVGEGFGGSLDGGHLLPNMRTIRQSKEPIVYLRLVFGRIYLFIASLLFGVAFRVCFTKIIKYEVWKASVLLHLQQQGPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JRX3</accession>
    <name>A0A9J7JRX3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="14">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Xrn2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Possesses 5'-&gt;3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with POLR2A and SMN1/SMN2. Interacts with CDKN2AIP and NKRF. Interacts with CDKN2AIPNL; the interaction is direct. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner. Interacts with DHX34; the interaction is RNA-independent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_027277388.1">
        <property type="nucleotide sequence ID" value="XM_027421587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JRX3"/>
    <dbReference type="GeneID" id="100770311"/>
    <dbReference type="KEGG" id="cge:100770311"/>
    <dbReference type="CTD" id="22803"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="17">
        <location>
            <begin position="326"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="408"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="902"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027277388.1"/>
        </source>
    </evidence>
    <sequence length="948" mass="108290" checksum="6F78020D55D9F751" modified="2023-06-28" version="1">MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCALCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFIRLNVLREYLERELTMASLPFPFDVERSIDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGCHVASNPRQAAYEMRMHSNSSPSISPNTSFASDGSPSPGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMSSEFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGGDVMFVGKLHPLHDFILELYQTGSTEPIDVPPELCHGIQGKFSLDEEAILPDQTVCSPVPMLRDLTQNTAVSINFKDPQFAEDYVFKAVMLPGARKPAAVLKPGDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGVYSNTAPPPATYQGSLYRPLLRGQTQIPKLMSNMRPQDSWRGPPPLFQQQRFDRSVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JVP2</accession>
    <name>A0A9J7JVP2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gastrin/cholecystokinin type B receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholecystokinin-2 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Cckbr</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297230.1">
        <property type="nucleotide sequence ID" value="XM_035441339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JVP2"/>
    <dbReference type="GeneID" id="100754060"/>
    <dbReference type="CTD" id="887"/>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015054">
        <property type="term" value="F:gastrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000314">
        <property type="entry name" value="Gastrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF45">
        <property type="entry name" value="GASTRIN_CHOLECYSTOKININ TYPE B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00527">
        <property type="entry name" value="GASTRINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 16 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="71"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035297230.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="53902" checksum="F8A12C4AE6CB0E3C" modified="2023-06-28" version="1">MELLKLNRSIPGSEPGPGSSLCRPGVPLLNGSSAGNLTCETPRIRGTGTRELELAIRVTLYAVIFLTSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTAVHPVGPRVLQCVHHWPSARVRQTWSVLLLLFLFFIPGVVMAVAYGLISRELYLGLRFDGDDSDTQSRVRNQGGLPGGAAPVGGSERSVERRQEPRVKAVGKGRRVKVGLRLASAFCFDRTLCVLCSGPVHQNGACRPETTQAGEDSDGCYVQLPRSRLEMTALTTPTPGPGPGSRPIQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLDTCARCCPRPPRAHPRPLPDEDPPTPSIASLSRLSYTTISTLGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JVY4</accession>
    <name>A0A9J7JVY4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: reelin domain-containing protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Reeld1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035297553.1">
        <property type="nucleotide sequence ID" value="XM_035441662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113834595"/>
    <dbReference type="KEGG" id="cge:113834595"/>
    <dbReference type="CTD" id="345051"/>
    <dbReference type="OrthoDB" id="2419613at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF51">
        <property type="entry name" value="REELIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="67"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035297553.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="54243" checksum="596416D6EC0C27C0" modified="2023-06-28" version="1">MAAEPAVRADRAFRLPAVVHCSQCLRSSVFPTNELLAPKGRCGLGLPVLEVAVRLSGACHFELLLSVAVSVRRSQDFLGFLLQAHTVTADQTVGXFVSTSPHCKLMTCFEEADXSDKTRKRKLFFLRKAPAQPVGDIRFLLSIIKSCFVYWARVELSVVSQPTHSGGHSANVHHTQPRSPALAPWRGQMLLKELYWVLLASCSQAWLSSSASAIVHSGSKHNASFLDNKNNRSVFLTVLEAERSKITSMSGAEDDSAYDDNVPRGEQRVCPSHLHTSGQQPTRQSNPTLQPSLDVHSFERLVSLRDGTLCSFVYIPSTHHREKLMEWTTELDRANHLGVEESDKKKGGGQIYPTQGDLSFDSLETCLHLDKDEQGSQSNSWLPSPWHSQESLGCIKALCWEYRVEEGVMGYLSKTNLRPGMRLQGTSAHLETQLRTPQLLILICLSTTVGVSLAAGXSEPTADAIARNDEGEXYMSKRQVNAYILVQVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JZN1</accession>
    <name>A0A9J7JZN1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Amine oxidase</fullName>
            <ecNumber evidence="19">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Aoc3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine. Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:25265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16424"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:225237"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25266"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59424"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17169"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:225238"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:59425"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>methylamine + O2 + H2O = formaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:59421"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="19">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="19">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="18">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer; disulfide-linked. Probably forms heterodimers with AOC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="18 19">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_027283859.1">
        <property type="nucleotide sequence ID" value="XM_027428058.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JZN1"/>
    <dbReference type="GeneID" id="100762926"/>
    <dbReference type="KEGG" id="cge:100762926"/>
    <dbReference type="CTD" id="8639"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000003">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000003">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF23">
        <property type="entry name" value="MEMBRANE PRIMARY AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 19" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17 19" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="21">
        <location>
            <begin position="66"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="22">
        <location>
            <begin position="169"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="20">
        <location>
            <begin position="315"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="17">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="18">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027283859.1"/>
        </source>
    </evidence>
    <sequence length="763" mass="84529" checksum="6DD512A188A31A2A" modified="2023-06-28" version="1">MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGGLSQPLHCPSIPPTAQPWTNPGQSQLFADLNPEELTAVMSFLTKHLGPGLVDPAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPAREALAIIFFGAQPQPNVTELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVTATEYNDIHKMIFNQELPQVSGLLHHCCFYKHRGHNLLTMTTVPRGLQSGDRATWFGVYYNLSGAGFYPHPIGLELLVNHKALIPEHWTIQKVFYQGRYFDSLAQLEDQFEAGLINVVLVPDNGTGGSWSLKSPVPPGSAPPLQFHPQGPRFSVQGYRVTSSLWTFSFGLGAYSGPRVFDVRFQGERVAYEVSVQEAIALYGGNSPAAMVTLYMDGHFGIGKYATPLTRGVDCPYLATYLDWHFLLESQTPTTLHDAFCVFEQNQGLPLRRHHSDFYSRYFGGVVETVLVVRSVSTLLNYDYVWDTIFHPNGAIEVKFHATGYISSAFFFGAGERFGNRVAAHTLGTVHTHSAHFKVDLDVAGLKNWAWAEDMAFVPMSIPWSPEYQIQRLQVNRKLLETEEEAAFPLGGATPRYLYLASNHSNKWGHRRGYRIQIFSFSGEPLPQKSPIEKAVSWGRYHFAVTRRKEEEPSSTSIFNQNDPWTPTVDFSGFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFREGQDTSDCEINPLACLSQTATCAPDVPGFSHAGFAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K539</accession>
    <name>A0A9J7K539_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase TRIM39</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING-type E3 ubiquitin transferase TRIM39</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Tripartite motif-containing protein 39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">LOC113832515</name>
        <name evidence="29" type="synonym">LOC100761321</name>
    </gene>
    <organism evidence="28 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29 30" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29 30">17A/GY</strain>
            <tissue evidence="29 30">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="RefSeq" id="XP_035306465.1">
        <property type="nucleotide sequence ID" value="XM_035450574.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309754.1">
        <property type="nucleotide sequence ID" value="XM_035453863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K539"/>
    <dbReference type="GeneID" id="113832515"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13745">
        <property type="entry name" value="SPRY_PRY_TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000171">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035033">
        <property type="entry name" value="PRY/SPRY_TRIM39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="26">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="27">
        <location>
            <begin position="300"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_035306465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_035309754.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="57928" checksum="DC61C12447A30267" modified="2023-06-28" version="1">MAEKRSMLEFEALAASTAAALENLQVEANCSVCLEYLKEPVILECGHNFCKVCITRCWEDLEQDFPCPVCRKTSQYQNLWPNRQLGSMVEIAKYLKRVRQKTREENLCFEHQEAMSLLCYEDQEAVCPTCAIYHTQQAHTVLQLDDVTKECKEKLQKCLELLNQKLRDISRCKASEEKKPGELKRLVESRRQQILKEFEELHRRLDEEQQTLLSRLEEEEQDILQRLRENAAHLGAKRQDLTYLVAEVECRSLLPGFKMLKDVKSTLEKCDKVKTMEVTTVSIELEKNFSNFPRQYFALRKILKQLIGDSPLWLLPPADVTLDPETAHPCLVLSEDRKSVKFVETRRRDLPDTPQRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRIRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGVSAGRKNAAPLTIRPPTDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K8I1</accession>
    <name>A0A9J7K8I1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Platelet glycoprotein Ib beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC113835359</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage. Interacts with TRAF4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035300035.1">
        <property type="nucleotide sequence ID" value="XM_035444144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K8I1"/>
    <dbReference type="GeneID" id="113835359"/>
    <dbReference type="KEGG" id="cge:113835359"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000441">
        <property type="entry name" value="Platelet glycoprotein Ib beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052313">
        <property type="entry name" value="GPIb-IX-V_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22650">
        <property type="entry name" value="GLYCOPROTEIN IB BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22650:SF7">
        <property type="entry name" value="PLATELET GLYCOPROTEIN IB BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039942459" description="Platelet glycoprotein Ib beta chain" evidence="17">
        <location>
            <begin position="32"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="18">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="19">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035300035.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="22880" checksum="15A0DEF880BEF90B" modified="2023-06-28" version="1">MLATHPSASLPGPRGALSLLLLLLARPNLPAAGCPAPCSCAGTVVDCGRRGLTWASLPAAFPPDTTELVLTGNNLTALPPGLLDALPALRAAHLGANPWRCDCRLLPLRAWLAGRREHEFYRDLRCVAPPAMRGRLLRYVAEEELRAACAPGLLCWGALVAQLALLVLGLLHALLLVLLLGRLRRLRAHARDWAFHELSLTGPLVAEPDGADAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KCR1</accession>
    <name>A0A9J7KCR1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRB2-associated-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118239752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035309424.1">
        <property type="nucleotide sequence ID" value="XM_035453533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KCR1"/>
    <dbReference type="GeneID" id="118239752"/>
    <dbReference type="KEGG" id="cge:118239752"/>
    <dbReference type="OrthoDB" id="67516at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046355">
        <property type="entry name" value="Gab1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960:SF1">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035309424.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37291" checksum="4281B2CE0DCCA210" modified="2023-06-28" version="1">MVQSDNASFSQSNVQESDTAAQKLAQGNRHSIHRVSSQVHDFYSLPKPSQYSGFDLPRSLASPSHTKADFSVSASDSEDMYTFKEPRNTPCSEFGDLPVDSAIAPPPLPPKTPWGSSPQQRPPDSDYKYPTRDGETACWCDKSPKKTIVGLPHNASSDDSYVSINPGSDIPMSTMPLHIASRGSEIQPPPVYRHLKPGRKAKPEPLDLRDNTVINELPFKSPVTKPWSTGNNTFNPSSSQYCHSISITDSGDCEENYVPMQNLTSSSPLPSGTNNPAPKKSTGNVNYIDPDFQKPSPSPQHKPSTSSLISDKKGVYVQIDEEKNQALQKTIQESTKMRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G3GTZ6</accession>
    <name>G3GTZ6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type phospholipid transporter</fullName>
            <ecNumber evidence="3">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Abca1</name>
        <name evidence="16" type="ORF">I79_001140</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JH000024">
        <property type="protein sequence ID" value="EGV97299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003495905.1">
        <property type="nucleotide sequence ID" value="XM_003495857.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258886.1">
        <property type="nucleotide sequence ID" value="XM_027403085.2"/>
    </dbReference>
    <dbReference type="STRING" id="10029.G3GTZ6"/>
    <dbReference type="GlyGen" id="G3GTZ6">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007635060.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022380.1">
        <property type="protein sequence ID" value="ENSCGRP00001018136.1"/>
        <property type="gene ID" value="ENSCGRG00001017941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761226"/>
    <dbReference type="KEGG" id="cge:100761226"/>
    <dbReference type="CTD" id="19"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AWQDYIS"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034186">
        <property type="term" value="F:apolipoprotein A-I binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034188">
        <property type="term" value="F:apolipoprotein A-I receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046623">
        <property type="term" value="F:sphingolipid floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034380">
        <property type="term" value="P:high-density lipoprotein particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002790">
        <property type="term" value="P:peptide secretion"/>
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    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0033700">
        <property type="term" value="P:phospholipid efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:phospholipid homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060155">
        <property type="term" value="P:platelet dense granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010875">
        <property type="term" value="P:positive regulation of cholesterol efflux"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090108">
        <property type="term" value="P:positive regulation of high-density lipoprotein particle assembly"/>
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    </dbReference>
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        <property type="term" value="P:protein secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032489">
        <property type="term" value="P:regulation of Cdc42 protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034616">
        <property type="term" value="P:response to laminar fluid shear stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043691">
        <property type="term" value="P:reverse cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023061">
        <property type="term" value="P:signal release"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000232">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000264">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF34">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="818"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1347"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1655"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1697"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1735"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1766"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1853"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="899"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1912"/>
            <end position="2144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV97299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027258886.1"/>
        </source>
    </evidence>
    <sequence length="2261" mass="254229" checksum="235413BC2F69C168" modified="2011-11-16" version="1">MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDARRLLLYSQKDTSIKDIHKVLRTLRQIKHSNPNLKLQDFLVDNETFSGFLHHNLSLPRQTVDILLKADVSLQKVFLQGYQLHLSSLCNGSKLEEIIQLGDLEVSALCGLPREKLDAAERVLRYNMDILKPVVTRLNSTSPLLTQHLAEATRTLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNSTEEDMETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQLWTFMESSQEMDLVRTLLDSRGNDRFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGLTPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLVSAGLLVIILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHLGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPRSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDVIDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTQELLNALTRDPGFGTRCMEGNPIPDTPCLVGDEDWTTAPVPQTIKDLFQNGNWTMKNPSPTCQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPPSQEVNDAIKQVKKLLKLTKDSSADRFLSSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILTNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3GWR3</accession>
    <name>G3GWR3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 10">Catechol O-methyltransferase domain-containing protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Catechol-O-methyltransferase domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Comtd1</name>
        <name evidence="6" type="ORF">I79_002193</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000053">
        <property type="protein sequence ID" value="EGV97825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003496783.1">
        <property type="nucleotide sequence ID" value="XM_003496735.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243305.1">
        <property type="nucleotide sequence ID" value="XM_027387504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GWR3"/>
    <dbReference type="STRING" id="10029.G3GWR3"/>
    <dbReference type="PaxDb" id="10029-XP_007621564.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029598.1">
        <property type="protein sequence ID" value="ENSCGRP00001025352.1"/>
        <property type="gene ID" value="ENSCGRG00001022974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762102"/>
    <dbReference type="KEGG" id="cge:100762102"/>
    <dbReference type="CTD" id="118881"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004409"/>
    <dbReference type="OMA" id="PYDMIFI"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000823">
        <property type="entry name" value="Catechol O-methyltransferase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF93">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV97825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027243305.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28905" checksum="4BA2D2298E90AD08" modified="2011-11-16" version="1">MAQPLLRISVPAALALGSAALGAAFATGLLLGRWWPAWGSRRQQRLLPPEDNPLWQYLLSRSMREHPALRSLRLLTLKHPQGDSMMTCEQAQLLANLARLIKAEKALDLGTFTGYSALALALALPEAGRVVTCEVDTEPPELGRPLWKQAEVEQKIDLRLQPALQTLDELLAAGEAGTFDVAVVDADKENCTAYYERCLQLLRPGGMLAVLRVLWRGEVLQPKPKDKAAECVRNLNERILRDARVYISLLPLGDGLSLAFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3GZ92</accession>
    <name>G3GZ92_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-wave-sensitive opsin 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Blue cone photoreceptor pigment</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Blue-sensitive opsin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29 33" type="primary">Opn1sw</name>
        <name evidence="28" type="ORF">H671_1g2306</name>
        <name evidence="27" type="ORF">I79_003126</name>
    </gene>
    <organism evidence="27 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="33" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
            <tissue evidence="33">Liver</tissue>
        </source>
    </reference>
    <reference evidence="29" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors. Involved in ensuring correct abundance and localization of retinal membrane proteins. May increase spectral sensitivity in dim light.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 24">Membrane</location>
            <topology evidence="1 24">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000073">
        <property type="protein sequence ID" value="EGV98174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE664704">
        <property type="protein sequence ID" value="ERE89496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497566.1">
        <property type="nucleotide sequence ID" value="XM_003497518.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247155.1">
        <property type="nucleotide sequence ID" value="XM_027391354.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GZ92"/>
    <dbReference type="SMR" id="G3GZ92"/>
    <dbReference type="STRING" id="10029.G3GZ92"/>
    <dbReference type="PaxDb" id="10029-XP_007636715.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027551.1">
        <property type="protein sequence ID" value="ENSCGRP00001023305.1"/>
        <property type="gene ID" value="ENSCGRG00001021579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751225"/>
    <dbReference type="KEGG" id="cge:100751225"/>
    <dbReference type="CTD" id="611"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234549"/>
    <dbReference type="OMA" id="QTAFMGF"/>
    <dbReference type="OrthoDB" id="6142583at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120199">
        <property type="term" value="C:cone photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071492">
        <property type="term" value="P:cellular response to UV-A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15076">
        <property type="entry name" value="7tmA_SWS1_opsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000018">
        <property type="entry name" value="Rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001521">
        <property type="entry name" value="Opsin_blue"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00574">
        <property type="entry name" value="OPSINBLUE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
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            <begin position="323"/>
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            <dbReference type="EMBL" id="ERE89496.1"/>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3H2P2</accession>
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    <organism evidence="3 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CHO K1 cell line</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">17A/GY</strain>
        </source>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8 9 10">17A/GY</strain>
            <tissue evidence="8 9 10">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
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        <property type="protein sequence ID" value="EGW04707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE675384">
        <property type="protein sequence ID" value="ERE75678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007630188.3"/>
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        <property type="nucleotide sequence ID" value="XM_027415297.2"/>
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        <property type="nucleotide sequence ID" value="XM_027415298.2"/>
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        <property type="nucleotide sequence ID" value="XM_027415299.2"/>
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    <dbReference type="RefSeq" id="XP_027271101.1">
        <property type="nucleotide sequence ID" value="XM_027415300.2"/>
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        <property type="glycosylation" value="1 site"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MPP_YkuE_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
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    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
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    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="207"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGW04707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ERE75678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027271098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027271099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027271100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027271101.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49181" checksum="9D61F3190FB83E25" modified="2011-11-16" version="1">MALFRQLSLGSKAALAAATVFVSMILSRSFLAETLELQAWRWLFRLQLVLFVNSLMLIGSLYIWRSTVSNLSHSPVVESTCFQLWKLVVTAFLALAHSSFFTMLFLVAEEPYVFSLAAYSCLGAYIIMVFFLCILNAMEQAYQFLAWRSGRVVGSLDKTRHLVLRPALAVAVTAVLSTIGLLNAAQPPVVKTVEVPIPQLPASMNNLRIVLLSDIHLGPTVGRTKMEMFVRMVNTLEPDITVIVGDLSDSEASILQTAVAPLGHLRSRLGTYFVTGNHEYYTSDVSNWFTLLESLHVRPLHNENVKISAPGDQDSGGAGKEWVCLAGVDDIEADILHYSGHGMDLDKALEGCSPDDTTILLAHQPLAAKRALQARPDINLILSGHTHAGQIFPWNVAAYLLNPFFAGLYQVGRATFVYVSPGTAYYGIPMRLGSRAEITELILWRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3H6P5</accession>
    <name>G3H6P5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8 11">Tripartite motif-containing protein 60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100756234</name>
        <name evidence="8" type="ORF">I79_006012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JH000179">
        <property type="protein sequence ID" value="EGV92633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003499916.2">
        <property type="nucleotide sequence ID" value="XM_003499868.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249852.1">
        <property type="nucleotide sequence ID" value="XM_027394051.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H6P5"/>
    <dbReference type="PaxDb" id="10029-XP_007628010.1"/>
    <dbReference type="GeneID" id="100756234"/>
    <dbReference type="KEGG" id="cge:100756234"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H6P5"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15828">
        <property type="entry name" value="SPRY_PRY_TRIM60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035786">
        <property type="entry name" value="SPRY/PRY_TRIM60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="280"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV92633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027249852.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="55173" checksum="84342DC64D815D54" modified="2011-11-16" version="1">MSSPTKLQGSMELKAAQVDLQAEAHCPICKEDFKNRVTIGCRHDFCHACISEFWKDRKGSFPCPVCHFNCPEGKFWSHEHLSQATEVSQPLPVKKIRNSPQGTCSSEMRPQPPAPCSGKDQEVFSPSPTSHFVWPIEDAALCTREQIEFYIKMWREKVEPAEKAIATQRRRSLELKRRVHLRREEVMSEYQQYMLILQNEEKSILEQLENEKVIALAKMNKNLENFSEHMSSLKCLLMEVEKKCAKSELELLASVKDVYKRNKNLECPRIVFFELKVRSLVLPPQYSGLDRIIKQFHVDVTLDPETAHCRLDVSEDKKAVLYGQMKELPNNQRRFHMYPIVLGSEGYSSGRQYWEVAVEHMCDWFLGVCKEPFPRSMDRSKNEQQPFSLQDGLWGVGLTSCQDYIGLGLKKIDLLPKVAPNRVGIFLDSDLHEVSFYNLSDKSLLCHFSDCASGALWPYFYTGYASVPLKICTAEDPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3H9V1</accession>
    <name>G3H9V1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RIKEN cDNA 5730409E04Rik gene</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">UPF0500 protein C1orf216 homolog</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">UPF0500 protein C1orf216-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">CUNH1orf216</name>
        <name evidence="1" type="ORF">I79_007182</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
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    </reference>
    <reference evidence="2" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH000238">
        <property type="protein sequence ID" value="EGW01089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003500888.5"/>
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    <dbReference type="RefSeq" id="XP_027255093.1">
        <property type="nucleotide sequence ID" value="XM_027399292.2"/>
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    <dbReference type="AlphaFoldDB" id="G3H9V1"/>
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    <dbReference type="Ensembl" id="ENSCGRT00001002020.1">
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    <dbReference type="GeneID" id="100767757"/>
    <dbReference type="KEGG" id="cge:100767757"/>
    <dbReference type="CTD" id="109318459"/>
    <dbReference type="eggNOG" id="ENOG502S1PX">
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    <dbReference type="OrthoDB" id="9900901at2759"/>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="Proteomes" id="UP001108280">
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    </evidence>
    <evidence type="ECO:0000313" key="5">
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">CHO K1 cell line</strain>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000490">
        <property type="protein sequence ID" value="EGW04590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE681232">
        <property type="protein sequence ID" value="ERE70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504514.1">
        <property type="nucleotide sequence ID" value="XM_003504466.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279391.1">
        <property type="nucleotide sequence ID" value="XM_027423590.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HLF8"/>
    <dbReference type="STRING" id="10029.G3HLF8"/>
    <dbReference type="PaxDb" id="10029-XP_007630316.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016203.1">
        <property type="protein sequence ID" value="ENSCGRP00001011970.1"/>
        <property type="gene ID" value="ENSCGRG00001013489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768346"/>
    <dbReference type="KEGG" id="cge:100768346"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162739"/>
    <dbReference type="OMA" id="AICFNPH"/>
    <dbReference type="OrthoDB" id="8772365at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="7tmA_OR1A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="83"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="103"/>
            <end position="121"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="142"/>
            <end position="163"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
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            <begin position="42"/>
            <end position="290"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW04590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027279391.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35068" checksum="4024528DB53B4C85" modified="2011-11-16" version="1">MERVNQNISVSEFILLGLSSRPEDQKPLFILLLTIYLVTIAGNLLIILAIYSDPHLQTPMYFFLSFLSFTDICFTTTIVPKMLVNFLSEKKTISYAGCLTQMYFLYALGNSDSCLLAVMAFDRYVAICNPFHYVTIMNHHRCVLLVTISCSLPHLHSLLHTLLLNCLTFCDSNVIHHFLCDLSPLIKLSCSSTFVNEIVIVTEGALVLVTPFLCIAFSYIRILLMVLKIPSAAGKHKAFSTCGSHLTVVTLFYGSIFYVYLQPVSTYTVKDHIATLVYTVLTSMLNPFIYSLRNKDLKQGLRKLMSRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3HPM5</accession>
    <name>G3HPM5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha N-terminal protein methyltransferase 1B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methyltransferase-like protein 11B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">N-terminal Xaa-Pro-Lys N-methyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Mettl11b</name>
        <name evidence="6" type="synonym">Ntmt2</name>
        <name evidence="5" type="ORF">I79_012740</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000580">
        <property type="protein sequence ID" value="EGW10331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505576.1">
        <property type="nucleotide sequence ID" value="XM_003505528.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272983.1">
        <property type="nucleotide sequence ID" value="XM_027417182.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HPM5"/>
    <dbReference type="STRING" id="10029.G3HPM5"/>
    <dbReference type="PaxDb" id="10029-XP_007628154.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016476.1">
        <property type="protein sequence ID" value="ENSCGRP00001012243.1"/>
        <property type="gene ID" value="ENSCGRG00001013692.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752444"/>
    <dbReference type="KEGG" id="cge:100752444"/>
    <dbReference type="CTD" id="149281"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008371"/>
    <dbReference type="OMA" id="ETYYCFN"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF2">
        <property type="entry name" value="N-TERMINAL XAA-PRO-LYS N-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGW10331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027272983.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32290" checksum="21C09E5F3FD2BE9B" modified="2011-11-16" version="1">MAHLGAHFAFRSRWQKTDDELCRHSMSFILHKAIRNDFFQSYLYLLEKIPLVKLYALTSQVIDGEMQFYARAKLFYQEVPATEEGMMGNFIELSNPDIQASREFLRKFVGGPGRAGTGCALDCGSGIGRVSKHVLLPVFSSVELVDMMESFLLEAQNYLQVIEDKVESYHCYSLQEFTPPLGRYDVIWIQWVSGYLTDKDLLAFLSRCRSGLKENGVIILKDNVAREGCIFDLSDSSVTRDMDILRSLIRKSGLVVLGQEKQEGFPEQCVPVWMFALHSDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3HT51</accession>
    <name>G3HT51_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger and BTB domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 23 24 25" type="primary">Zbtb14</name>
        <name evidence="19" type="ORF">I79_014069</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23 24 25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23 24 25">17A/GY</strain>
            <tissue evidence="23 24 25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with ZBTB21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000686">
        <property type="protein sequence ID" value="EGW09824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007645346.1">
        <property type="nucleotide sequence ID" value="XM_007647156.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253609.1">
        <property type="nucleotide sequence ID" value="XM_027397808.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253610.1">
        <property type="nucleotide sequence ID" value="XM_027397809.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253611.1">
        <property type="nucleotide sequence ID" value="XM_027397810.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HT51"/>
    <dbReference type="PaxDb" id="10029-XP_007623264.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013515.1">
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        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR KAISO"/>
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        <location>
            <begin position="36"/>
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    <sequence length="449" mass="50900" checksum="C805ED0FCCE42C4B" modified="2011-11-16" version="1">MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDESNGQSKSKYCLKLNRPMGDAADAQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMGEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHNDRKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS</sequence>
</entry>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Myomorpha</taxon>
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            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="EGW09751.1"/>
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        <property type="nucleotide sequence ID" value="XM_003509541.5"/>
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        <property type="nucleotide sequence ID" value="XM_027424904.2"/>
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        <property type="protein sequence ID" value="ENSCGRP00001022385.1"/>
        <property type="gene ID" value="ENSCGRG00001020943.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="9939072at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031518">
        <property type="entry name" value="DUF4693"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14870">
        <property type="entry name" value="TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14870:SF1">
        <property type="entry name" value="TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15764">
        <property type="entry name" value="DUF4693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW09751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027280705.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="47690" checksum="BC889E1A84BBC259" modified="2011-11-16" version="1">MLGAKVDCLLPTDCARRLVAEMQGALDACAHRQRQLERSLRVSRRLLQVWEPARTPAPEPETKEEAATPACTPNAQDLKELELLTQALEKAVRVRKVVSKARQRDRTPSLASASNAATSGATAPAHSQAPSQASSLASGARSTKGVQRATVPSRSADPECRRRSRGDRTQERTEAQVTGSGPGLRGQQMAPGAVPPSTELFTLKEKGTLLQLPVAFRKAASQNSRLWAQLSSIQASDSTDVTRAAKTEFLHKLQMASGSSSHRPSAAEVEAHVQSLRKARTLLRLHMQKELSTAPTDWMQEYRGLLILEGLQTIVGQCLHRVQVLQAAVTEQLPGLHLVEKPTQASSLGGGEMDTSWSPELLLYSSTEELQTLATLKLRVAMLDQQIHLEKVLMAELFPLINTQEAGGSPQLALCRAAYSLLCEGGEQFLTVLRDDPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G3I5T3</accession>
    <name>G3I5T3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable ATP-dependent RNA helicase DDX6</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DEAD box protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Oncogene RCK homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable ATP-dependent RNA helicase ddx6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 28 29 30 31 32 33" type="primary">Ddx6</name>
        <name evidence="23" type="ORF">H671_4g12986</name>
        <name evidence="22" type="ORF">I79_018840</name>
    </gene>
    <organism evidence="22 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28 29 30" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28 29 30">17A/GY</strain>
            <tissue evidence="28 29 30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JH001318">
        <property type="protein sequence ID" value="EGW05727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE675610">
        <property type="protein sequence ID" value="ERE75009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510566.1">
        <property type="nucleotide sequence ID" value="XM_003510518.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649340.1">
        <property type="nucleotide sequence ID" value="XM_007651150.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267757.1">
        <property type="nucleotide sequence ID" value="XM_027411956.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267758.1">
        <property type="nucleotide sequence ID" value="XM_027411957.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267759.1">
        <property type="nucleotide sequence ID" value="XM_027411958.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267760.1">
        <property type="nucleotide sequence ID" value="XM_027411959.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267761.1">
        <property type="nucleotide sequence ID" value="XM_027411960.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267762.1">
        <property type="nucleotide sequence ID" value="XM_027411961.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I5T3"/>
    <dbReference type="SMR" id="G3I5T3"/>
    <dbReference type="STRING" id="10029.G3I5T3"/>
    <dbReference type="PaxDb" id="10029-XP_007618913.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030278.1">
        <property type="protein sequence ID" value="ENSCGRP00001026032.1"/>
        <property type="gene ID" value="ENSCGRG00001023465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759836"/>
    <dbReference type="KEGG" id="cge:100759836"/>
    <dbReference type="CTD" id="1656"/>
    <dbReference type="eggNOG" id="KOG0326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141067"/>
    <dbReference type="OMA" id="PRDHQMI"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035278">
        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019827">
        <property type="term" value="P:stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019074">
        <property type="term" value="P:viral RNA genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="127"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="308"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGW05727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ERE75009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027267757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027267758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027267759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027267760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027267761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_027267762.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="54373" checksum="C911CE16EB11D42F" modified="2011-11-16" version="1">MSTARTENPVIMGLSSQNGQLRGPVKPSGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTATIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3I7K0</accession>
    <name>G3I7K0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 21">Neuroligin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Nlgn3</name>
        <name evidence="17" type="ORF">I79_019492</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001436">
        <property type="protein sequence ID" value="EGW02956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511093.1">
        <property type="nucleotide sequence ID" value="XM_003511045.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306174.1">
        <property type="nucleotide sequence ID" value="XM_035450283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I7K0"/>
    <dbReference type="STRING" id="10029.G3I7K0"/>
    <dbReference type="ESTHER" id="crigr-g3i7k0">
        <property type="family name" value="Neuroligin"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.987"/>
    <dbReference type="GlyGen" id="G3I7K0">
        <property type="glycosylation" value="2 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007634306.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000721.1">
        <property type="protein sequence ID" value="ENSCGRP00001000697.1"/>
        <property type="gene ID" value="ENSCGRG00001000542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755495"/>
    <dbReference type="KEGG" id="cge:100755495"/>
    <dbReference type="CTD" id="54413"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159580"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031644">
        <property type="term" value="P:regulation of nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000001">
        <property type="entry name" value="Neuroligin 3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732350" evidence="15">
        <location>
            <begin position="38"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="16">
        <location>
            <begin position="41"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="625"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW02956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035306174.1"/>
        </source>
    </evidence>
    <sequence length="828" mass="91566" checksum="256C03475356DD9D" modified="2011-11-16" version="1">MWLQLGLPLLSPSPTPTVGRSLCLTLWFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPVGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGPAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPHSHSTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3IA36</accession>
    <name>G3IA36_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lung adenoma susceptibility protein 2 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RIKEN cDNA 4930503L19 gene</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein C18orf54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C2H18orf54</name>
        <name evidence="6" type="synonym">CUNH18orf54</name>
        <name evidence="2" type="ORF">I79_020453</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH001668">
        <property type="protein sequence ID" value="EGW01125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007650539.1">
        <property type="nucleotide sequence ID" value="XM_007652349.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295960.1">
        <property type="nucleotide sequence ID" value="XM_035440069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IA36"/>
    <dbReference type="STRING" id="10029.G3IA36"/>
    <dbReference type="PaxDb" id="10029-XP_007626922.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012505.1">
        <property type="protein sequence ID" value="ENSCGRP00001008377.1"/>
        <property type="gene ID" value="ENSCGRG00001010669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756190"/>
    <dbReference type="CTD" id="121304327"/>
    <dbReference type="eggNOG" id="ENOG502RM40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008823"/>
    <dbReference type="OrthoDB" id="9934714at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052679">
        <property type="entry name" value="Cell_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031587">
        <property type="entry name" value="LAS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35079">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35079:SF1">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15792">
        <property type="entry name" value="LAS2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGW01125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035295960.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59890" checksum="C71DA77A80290628" modified="2011-11-16" version="1">MAKSNTKHRVCSRESSVTSLLASCSLSGGSSSSSNSSFHYKDKLYSSASEALQAYIDDFDLSREHSGANTGRVNIDEESGNMLRFSSYVHKPNNAFENLDHKQHLNSLCYRRETINDMDSISLTTDDLLRLPADGSFSFTSVIPGHRPSEKNKKYIERQDSSSDIKKKPNFHIDSTPKSKDNVVTCDVYSNVNGKKCGRPGTLKPVNRNNKRVLESSLSIPKESSFKDSSNYGPEMNYPRWLTSQKSDLNISGVTSIPDFKYPIWLHNQDLLPDANNQSVSKLLNEDEYSPVHSYQKQRTTQLTNEVDGFEYSFQPVNFTDSFIENKGLVNQCKCDSENGQCHCENLLLPGQSPKPFCGDKIELLILKAKKNLRQSTEDLAKPVEKDDSPCSLDKLEAERSWENVPVTFKSPVPVNADDSPQQSSGTQCIDEILEDSLNDENQSSTLSGGKHHGPVEALKQMLFNLQAVQESFNQNKNTDPEEEFIQVSEDDFSTLQLKENMIPITRSLQTALQHLSRLRDLVDDTSGKQSPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3IEN9</accession>
    <name>G3IEN9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC100764419</name>
        <name evidence="15" type="ORF">H671_3g9753</name>
        <name evidence="14" type="ORF">I79_022190</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002236">
        <property type="protein sequence ID" value="EGW07341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE672560">
        <property type="protein sequence ID" value="ERE79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513304.1">
        <property type="nucleotide sequence ID" value="XM_003513256.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263842.1">
        <property type="nucleotide sequence ID" value="XM_027408041.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IEN9"/>
    <dbReference type="STRING" id="10029.G3IEN9"/>
    <dbReference type="PaxDb" id="10029-XP_007633568.1"/>
    <dbReference type="GeneID" id="100764419"/>
    <dbReference type="KEGG" id="cge:100764419"/>
    <dbReference type="eggNOG" id="ENOG502QW9N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15221">
        <property type="entry name" value="7tmA_OR52B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF12">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW07341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027263842.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35432" checksum="DCC28092410789B3" modified="2011-11-16" version="1">MVMHNMSSYNTGPFTLSGIPGLEQYHVWISIPFCFIYLVAIVGNGLLLYLIAVENSLHSPMFFFLSMLATTDLILSTTCVPKTLSIFWFGPQEISFPGCLTQLFFLHYSFVLDSAILLAMAFDRYVAICSPLRYTTILTPKAVVKIAVGISFRSFCVFVPCVFLVNRLPFCRTHVIAHTYCEHIGVARLACADISINIWYGFCVPIMTVITDVVLIAISYTLILCAVFRLPSRDARQKALGTCGSHVCVILMFYIPAFFSILAHRFGHNVPRTFHIMFANLYVIIPPALNPVVYGVKTKQIRDKAILLLFPKWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3IFT4</accession>
    <name>G3IFT4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA methyltransferase 10 homolog A</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA (guanine-9-)-methyltransferase domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA (guanine(9)-N(1))-methyltransferase TRMT10A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">Trmt10a</name>
        <name evidence="14" type="ORF">I79_022607</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="4">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with tRNA.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="JH002448">
        <property type="protein sequence ID" value="EGW13798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007652048.1">
        <property type="nucleotide sequence ID" value="XM_007653858.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251603.1">
        <property type="nucleotide sequence ID" value="XM_027395802.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251604.1">
        <property type="nucleotide sequence ID" value="XM_027395803.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035293298.1">
        <property type="nucleotide sequence ID" value="XM_035437407.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306768.1">
        <property type="nucleotide sequence ID" value="XM_035450877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IFT4"/>
    <dbReference type="SMR" id="G3IFT4"/>
    <dbReference type="STRING" id="10029.G3IFT4"/>
    <dbReference type="PaxDb" id="10029-XP_007628996.1"/>
    <dbReference type="GeneID" id="100758993"/>
    <dbReference type="KEGG" id="cge:100758993"/>
    <dbReference type="CTD" id="93587"/>
    <dbReference type="eggNOG" id="KOG2967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3IFT4"/>
    <dbReference type="OMA" id="FKKNDGW"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18101">
        <property type="entry name" value="Trm10euk_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000001">
        <property type="entry name" value="tRNA methyltransferase 10 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016653">
        <property type="entry name" value="TRM10/TRM10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016323">
        <property type="entry name" value="tRNA_m1G_mtfrase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 14 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="13">
        <location>
            <begin position="89"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="282"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016323-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW13798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027251603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027251604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035306768.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38713" checksum="6115AFBA553E4F05" modified="2011-11-16" version="1">MSSEMLPVSVETPNVEKEPGVSEGDEERHKPRLDAGTEPISKRQMKKLMKQKQWEEQRELRREKRKEKRKRKKLERQHQLESGSDGSDRKRIRRDGVHSSLRLVIDCSFDDLMVLKDIKKLHKQIQRCYAENRRASHPVQFYLTSHGGQLKQNMDENDRGWVNWKDIHIKSEHYSELIKKEDLVYLTSDSPNVLKDLDESKAYVIGGLVDHNHHKGLTFKQASSHGIEHAQLPLADFVKMNSRKVLAVNHVFEIILEFLETRDWQEAFFTILPQRKGAVPAHKAYENSSQDQQPRPEGWDSSSEGENCRNDPASPQKEEQGPQSSPVSSVSSVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3ILF6</accession>
    <name>G3ILF6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">LOC100752097</name>
        <name evidence="15" type="ORF">I79_024721</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH004014">
        <property type="protein sequence ID" value="EGW14734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003515290.1">
        <property type="nucleotide sequence ID" value="XM_003515242.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244460.1">
        <property type="nucleotide sequence ID" value="XM_027388659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ILF6"/>
    <dbReference type="STRING" id="10029.G3ILF6"/>
    <dbReference type="PaxDb" id="10029-XP_007632114.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011620.1">
        <property type="protein sequence ID" value="ENSCGRP00001007569.1"/>
        <property type="gene ID" value="ENSCGRG00001009969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752097"/>
    <dbReference type="KEGG" id="cge:100752097"/>
    <dbReference type="eggNOG" id="ENOG502SJYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9442215at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15947">
        <property type="entry name" value="7tmA_OR2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000005">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGW14734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027244460.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34961" checksum="47BBC775A52F7FFC" modified="2011-11-16" version="1">MTVNKSSDGDFILVGFSDQPQLEKALFVVVLIFYLLTLVGNTAIILASCLDSTLQTPMYYFLTNLSFVDICFSTSIVPQLLWNLHGPAKTITPTGCAIQLYVSLALGSTECVLLAVMAFDRYAAVCRPLHYTTVMHPRLCQSLAGIAWLSGVGNTLIQGTITLRLPRCGNHRIYHFICEVPAMIKLACVDIHANEVQLFMASLVLLLLPLALILVSYGYIAQVLMRLRSALTWGKALGTCGSHLLVVVLFYGTITAVYIQPNSSYAHSQGKFITLLYTVVIPTLNPLIYTLRNKDVKGALKRLVRKNNSTRDKILSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>O54935</accession>
    <name>XRCC1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>DNA repair protein XRCC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>X-ray repair cross-complementing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">XRCC1</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Nucleic Acids Res." volume="26" first="1032" last="1037">
            <title>Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair.</title>
            <authorList>
                <person name="Shen M.R."/>
                <person name="Zdzienicka M.Z."/>
                <person name="Mohrenweiser H."/>
                <person name="Thompson L.H."/>
                <person name="Thelen M.P."/>
            </authorList>
            <dbReference type="PubMed" id="9461464"/>
            <dbReference type="DOI" id="10.1093/nar/26.4.1032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>VARIANTS LYS-102 AND TYR-390</scope>
        <source>
            <tissue>Ovary</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. Interacts with (poly-ADP-ribosylated) PARP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <text evidence="1">Moves from the nucleoli to the global nuclear chromatin upon DNA damage. Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylation of Ser-372 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Sumoylated.</text>
    </comment>
    <dbReference type="EMBL" id="AF034203">
        <property type="protein sequence ID" value="AAC40038.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233608.1">
        <property type="nucleotide sequence ID" value="NM_001246679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O54935"/>
    <dbReference type="SMR" id="O54935"/>
    <dbReference type="PaxDb" id="10029-NP_001233608.1"/>
    <dbReference type="GeneID" id="100689414"/>
    <dbReference type="KEGG" id="cge:100689414"/>
    <dbReference type="CTD" id="7515"/>
    <dbReference type="eggNOG" id="KOG3226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25840at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="BHF-UCL"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17725">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17707">
        <property type="entry name" value="BRCT_XRCC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000025">
        <property type="entry name" value="DNA repair protein XRCC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000008">
        <property type="entry name" value="X-ray repair cross complementing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000012">
        <property type="entry name" value="X-ray repair cross complementing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045080">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF5">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000066043" description="DNA repair protein XRCC1">
        <location>
            <begin position="1"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 1" evidence="2">
        <location>
            <begin position="316"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 2" evidence="2">
        <location>
            <begin position="538"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In a mutant cell line defective in DNA repair." evidence="4">
        <original>E</original>
        <variation>K</variation>
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In a mutant cell line defective in DNA repair." evidence="4">
        <original>C</original>
        <variation>Y</variation>
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P18887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="9461464"/>
        </source>
    </evidence>
    <sequence length="633" mass="69147" checksum="1C0A1427D9059FC6" modified="1998-06-01" version="1">MPEISLRHVVSGSSQDSTHCAENLLKADTYRKWRAATAGEKTISVVLQLEKEEQIHSIDIGNDGSAFVEVLVTRSAGGGGATAIEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPYGLSFVRFHSPPDKDEAETPSQKGTVTKLGQFRVKEEDDGASSLKPGALFFSRINKTSSASARGPAGPSYAAATLQASNATSSASSVSKALGSSCKPQESPKGKRKLDLNLEDRRPASKPSAGPPTLKRPKLTVPSRSPAAAAASTPAQKAAPGKPREGTEPRGARAGPQELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTPDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCYRLRRRLPSRRYLMAGLGSSSEDEEDDSPGESGEDEAPKLSRKRPQAKAKTQAAGPSSPQRPPTPKETKSPSPEPQDNSDTEGEQSEGQDNGAEDSGDTEDELRRVAEQREQRQPPAPGENGEDPYAGSTDENTDNEASTEADLPIPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDYMSERVQFVITAQEWDPIFEEALMENPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q60455</accession>
    <name>Q60455_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Tubb4b</name>
        <name evidence="19" type="synonym">Tubb2c</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="1991" name="Biochim. Biophys. Acta" volume="1090" first="252" last="254">
            <title>Nucleotide sequences of three different isoforms of beta-tubulin cDNA from Chinese hamster ovary cells.</title>
            <authorList>
                <person name="Ahmad S."/>
                <person name="Singh B."/>
                <person name="Gupta R.S."/>
            </authorList>
            <dbReference type="PubMed" id="1657186"/>
            <dbReference type="DOI" id="10.1016/0167-4781(91)90112-Y"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
            <authorList>
                <person name="Becker J."/>
                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
            </authorList>
            <dbReference type="PubMed" id="21945585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="X60785">
        <property type="protein sequence ID" value="CAA43198.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="PIR" id="S18457">
        <property type="entry name" value="S18457"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001231027.1">
        <property type="nucleotide sequence ID" value="NM_001244098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q60455"/>
    <dbReference type="SMR" id="Q60455"/>
    <dbReference type="GeneID" id="100689089"/>
    <dbReference type="KEGG" id="cge:100689089"/>
    <dbReference type="CTD" id="10383"/>
    <dbReference type="OrthoDB" id="9987387at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="245"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAA43198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="NP_001231027.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49748" checksum="96BDD92F1B126393" modified="1996-11-01" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSAFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q8VI73</accession>
    <name>TALDO_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Transaldolase</fullName>
            <ecNumber evidence="1">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TALDO1</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Perl A."/>
                <person name="Banki K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Ovary</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:17054"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:17055"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with KPNA1 and KPNA4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The first 10 amino acids are essential for nuclear localization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AF128242">
        <property type="protein sequence ID" value="AAL55523.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8VI73"/>
    <dbReference type="SMR" id="Q8VI73"/>
    <dbReference type="PaxDb" id="10029-NP_001233704.1"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000002">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173563" description="Transaldolase">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P37837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q93092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="337" mass="37386" checksum="B6AED8B21FB1C374" modified="2002-03-01" version="1">MSGSPVKRQRMESALDQLKQFTTVVADTGDFNAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGKKLGGPQEEQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARAKRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPQEDPGVKSVTKIYNYYKKFGYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLKDNTKLAPVLSIKAAQTSDLGKIHLDEKAFRWLHSEDQMAVEKLSDGIRKFAADAIKLERMLTERMFSAENGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q9Z313</accession>
    <name>RL13_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL13</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-05" db="EMBL/GenBank/DDBJ databases">
            <title>Identification of genes highly expressed in association with G2 arrest induced by DNA damage of Chinese hamster overy cells by differential display.</title>
            <authorList>
                <person name="Sasaki Y."/>
                <person name="Itoh F."/>
                <person name="Suzuki H."/>
                <person name="Hinoda Y."/>
                <person name="Imai K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 60S large ribosomal subunit (LSU).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AB014876">
        <property type="protein sequence ID" value="BAA34291.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233732.1">
        <property type="nucleotide sequence ID" value="NM_001246803.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z313"/>
    <dbReference type="SMR" id="Q9Z313"/>
    <dbReference type="MINT" id="Q9Z313"/>
    <dbReference type="PaxDb" id="10029-NP_001233732.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029001">
        <property type="protein sequence ID" value="ENSCGRP00001024755"/>
        <property type="gene ID" value="ENSCGRG00001022563"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00015077266">
        <property type="protein sequence ID" value="ENSCGRP00015047873"/>
        <property type="gene ID" value="ENSCGRG00015020336"/>
    </dbReference>
    <dbReference type="GeneID" id="100689376"/>
    <dbReference type="KEGG" id="cge:100689376"/>
    <dbReference type="CTD" id="6137"/>
    <dbReference type="eggNOG" id="KOG3295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007818"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000192918" description="Large ribosomal subunit protein eL13">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P26373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="211" mass="24393" checksum="5860CA75674A19A6" modified="2007-01-23" version="3">MAPSRNGMILKPHFHKDWQRRVDTWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMRIRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ICL8</accession>
    <name>A0A061ICL8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 20">Vacuolar protein sorting-associated protein 41 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26 29" type="primary">Vps41</name>
        <name evidence="25" type="ORF">H671_3g8578</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="26" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Early endosome membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Endosome membrane</location>
            <topology evidence="20">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4 20">Late endosome membrane</location>
            <topology evidence="4 20">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18 20">Lysosome membrane</location>
            <topology evidence="18 20">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 20">Golgi apparatus</location>
            <location evidence="3 20">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cytoplasmic vesicle</location>
            <location evidence="20">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the VPS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE670879">
        <property type="protein sequence ID" value="ERE80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003496290.1">
        <property type="nucleotide sequence ID" value="XM_003496242.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265183.1">
        <property type="nucleotide sequence ID" value="XM_027409382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061ICL8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023399.1">
        <property type="protein sequence ID" value="ENSCGRP00001019155.1"/>
        <property type="gene ID" value="ENSCGRG00001018659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768202"/>
    <dbReference type="KEGG" id="cge:100768202"/>
    <dbReference type="CTD" id="27072"/>
    <dbReference type="GeneTree" id="ENSGT00390000000481"/>
    <dbReference type="OMA" id="PQLVWQD"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16690">
        <property type="entry name" value="RING-H2_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000247">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000107">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057779">
        <property type="entry name" value="Znf_RING_Vps41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23555">
        <property type="entry name" value="zf-RING_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17 20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 20" id="KW-0967">Endosome</keyword>
    <keyword evidence="14 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16 20" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 20" id="KW-0653">Protein transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="22">
        <location>
            <begin position="567"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="790"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ERE80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027265183.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="98318" checksum="9A3691894745113A" modified="2014-09-03" version="1">MAEAEEQETGSLEESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDESGEHMGVCSEDGKVQVFGLYSGEEFHETFDCPIKIIAVHPQFVRSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDITSKQRITNVPRDDISLRPDMYPCSLCWKDTVTLIIGWGTSIKICSVKERHASEMRDLPNRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEVSEKTEREYCARPRLDIIQPLPETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQRNIKRHKILDIGLAYINHLVARGEYDMAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQCYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICSAKSRGPGSAILEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061INQ8</accession>
    <name>A0A061INQ8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein MAK16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Mak16</name>
        <name evidence="8" type="ORF">H671_1g1196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE663660">
        <property type="protein sequence ID" value="ERE91087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244898.1">
        <property type="nucleotide sequence ID" value="XM_027389097.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061INQ8"/>
    <dbReference type="GeneID" id="100760844"/>
    <dbReference type="KEGG" id="cge:100760844"/>
    <dbReference type="CTD" id="84549"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000003">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="7">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ERE91087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027244898.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="35020" checksum="CB5ACC234C33A245" modified="2014-09-03" version="1">MQSDDVIWNTLGNKQFCSFKIRTKTQGFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLSKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRRKKLVPLSKKVERREKRREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEKQEAESDSEEEDEEEDEEDVGKREFVEDDEVDESDLSDFEDMDKLDAGSDEGQDEESSSEEEEEKALKAKHKGKAPLKGPLRKKRAYVEIEYEQETEPMTKAKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IP97</accession>
    <name>A0A061IP97_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 17 18">Epiphycan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 17 18" type="primary">Epyc</name>
        <name evidence="13" type="ORF">H671_1g2239</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18">17A/GY</strain>
            <tissue evidence="17 18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE664676">
        <property type="protein sequence ID" value="ERE89587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016831835.1">
        <property type="nucleotide sequence ID" value="XM_016976346.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249914.1">
        <property type="nucleotide sequence ID" value="XM_027394113.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307419.1">
        <property type="nucleotide sequence ID" value="XM_035451528.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312696.1">
        <property type="nucleotide sequence ID" value="XM_035456805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IP97"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000300.1">
        <property type="protein sequence ID" value="ENSCGRP00001000276.1"/>
        <property type="gene ID" value="ENSCGRG00001000236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754407"/>
    <dbReference type="KEGG" id="cge:100754407"/>
    <dbReference type="CTD" id="1833"/>
    <dbReference type="GeneTree" id="ENSGT00940000157574"/>
    <dbReference type="OMA" id="EFYDIPL"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005615">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:articular cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000167">
        <property type="entry name" value="epiphycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043547">
        <property type="entry name" value="Mimecan/Epiphycan/Opticin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269:SF3">
        <property type="entry name" value="EPIPHYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269">
        <property type="entry name" value="EPIPHYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044538928" evidence="11">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
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    <evidence type="ECO:0000259" key="12">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
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            <dbReference type="EMBL" id="ERE89587.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000276.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027249914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035307419.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36899" checksum="F6F0C5B4324D9B7D" modified="2014-09-03" version="1">MKMLARIVLVLIIFDATLTAPTTELFNYDSEVYDAILEDVGTFYNYEQIPINQVETEKVTERLSGNRELLTPGPQLEDTQDEDKDEESTPRLIDGSSPQEPEFPGLLGPHTNEDFPTCLLCTCISTTVYCDDQELDAIPPLPKKTAYFYSRFNRIKKINKNDFANLSDLKRIDLTSNLISEIDEDAFRKLPHLQELVLRDNKIKQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYITDNSLDHIPLPLPESLQALHLQNNNILEMHEDTFCNVKNLTYVRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7ILG0</accession>
    <name>A0A3L7ILG0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock 70 kDa protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">LOC100760804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with PRKN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the heat shock protein 70 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027388812.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7ILG0"/>
    <dbReference type="SMR" id="A0A3L7ILG0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000936.1">
        <property type="protein sequence ID" value="ENSCGRP00001000912.1"/>
        <property type="gene ID" value="ENSCGRG00001000703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760804"/>
    <dbReference type="KEGG" id="cge:100760804"/>
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    </dbReference>
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    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002199">
        <property type="term" value="C:zona pellucida receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903955">
        <property type="term" value="P:positive regulation of protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000019">
        <property type="entry name" value="Heat shock 70 kDa protein 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027244613.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="70561" checksum="425CEAF93F1860CA" modified="2019-02-13" version="1">MAANKGMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVLVSYKGEKKAFYPEEISSMVLTKMKETAEAFLGHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLFEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMDKAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEGQREKIAAKNALESYAFNMKSAVSDEGLKDKISESDKKKILDKCNEVLSWLEANQLAEKDEFDHKRKELENMCNPVITKLYQGGCTGPTCAPGYTPSRAATGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LD49</accession>
    <name>A0A8C2LD49_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromodomain Y-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Crotonyl-CoA hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Cdyl</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:78611"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027266157.1">
        <property type="nucleotide sequence ID" value="XM_027410356.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LD49"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003265.1">
        <property type="protein sequence ID" value="ENSCGRP00001002466.1"/>
        <property type="gene ID" value="ENSCGRG00001002703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763740"/>
    <dbReference type="KEGG" id="cge:100763740"/>
    <dbReference type="CTD" id="9425"/>
    <dbReference type="GeneTree" id="ENSGT00940000155106"/>
    <dbReference type="OrthoDB" id="6357915at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18634">
        <property type="entry name" value="CD_CDY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000006">
        <property type="entry name" value="Chromodomain Y-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000012">
        <property type="entry name" value="Chromodomain Y-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000029">
        <property type="entry name" value="chromodomain Y-like protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF5">
        <property type="entry name" value="CHROMODOMAIN Y-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027266157.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="60334" checksum="F5F336B0FC9EB95E" modified="2022-01-19" version="1">MASEELYEVERIVDKRKNKKGKTEYLVRWKGYESEDDTWEPEQHLVNCEEYIHDFNRRHSERQKEGSLARANRSSPSNARKQISRSTHSNLSKTTPKALVVGKDHESKNSQLLATSQKFRKNTAPSLANRKNMDLAKSGIKILVPKSPVKGRTSVDGFQGESPEKLDPIEQGPEDTTAPEVTAEKPVGALLGPGAERARMGSRPRIHPLVPQVSGPVTAAMATGLAVNGKGTSPFMDALTANGTATIQTSVTGVTAGKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEVMKEVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMADAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLLSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LG71</accession>
    <name>A0A8C2LG71_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100763435</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263802.1">
        <property type="nucleotide sequence ID" value="XM_027408001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LG71"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003653.1">
        <property type="protein sequence ID" value="ENSCGRP00001002682.1"/>
        <property type="gene ID" value="ENSCGRG00001003040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763435"/>
    <dbReference type="KEGG" id="cge:100763435"/>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15917">
        <property type="entry name" value="7tmA_OR51_52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF116">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027263802.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35368" checksum="6E5769EBF1A5E391" modified="2022-01-19" version="1">MPSCNHSIPQPTIFTLAGIPGLESSQGWFSVPFFLIFVITIIGNITILSIIWIERSLHEPMFLLLATLSVVDLCLVIVTVPRMLGIFWMNAKEISFDACLTQMFFIPSFYVMESGILLAMAFDRFVAICYPLRYTTILDYSMLLKMVLAILARAVTVLTPAPILTKRLEQFQTKVIAYSYCAYMALVMIACGDITNHIVYGLLVIVASVGVDLVFVILSYILILHAVFHIPSWQARSKALSTCGSHLCVIGLFYSPVVFSVLSQILGYHMAPYLQIIIDNLYFLVPPMVNPLIYAARTKQMREWVFQVLSCHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LJP0</accession>
    <name>A0A8C2LJP0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11 14">Neurogenin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">LOC113833495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027251483.1">
        <property type="nucleotide sequence ID" value="XM_027395682.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LJP0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005052.1">
        <property type="protein sequence ID" value="ENSCGRP00001003492.1"/>
        <property type="gene ID" value="ENSCGRG00001004256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113833495"/>
    <dbReference type="KEGG" id="cge:113833495"/>
    <dbReference type="GeneTree" id="ENSGT00940000162895"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19717">
        <property type="entry name" value="bHLH_TS_NGN2_ATOH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032655">
        <property type="entry name" value="Ngn-2_bHLH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF171">
        <property type="entry name" value="NEUROGENIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027251483.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="28290" checksum="81D0FB5877CEE087" modified="2022-01-19" version="1">MFVKSETLELKEEEEVLMLLGSASPASATLTPMTSSADEEEDEELRRPGAVLGQRGAEGGQGAQGSSASGAGGCRPARLLGLVHECKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCAGGGGLQGALFSEAVLLSPSAALGAGGDSPSPPSSSWSCTNSPASSSASSSSTSPYSCTLSPASPGSDVDYWQPPPPDKHRYAPHLPVARDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LMB8</accession>
    <name>A0A8C2LMB8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dermatan sulfate epimerase-like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15 16 17">Dermatan-sulfate epimerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15 16 17" type="primary">Dsel</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16 17">17A/GY</strain>
            <tissue evidence="15 16 17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatan-sulfate isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003508508.1">
        <property type="nucleotide sequence ID" value="XM_003508460.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007647271.1">
        <property type="nucleotide sequence ID" value="XM_007649081.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273679.1">
        <property type="nucleotide sequence ID" value="XM_027417878.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273680.1">
        <property type="nucleotide sequence ID" value="XM_027417879.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301287.1">
        <property type="nucleotide sequence ID" value="XM_035445396.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315741.1">
        <property type="nucleotide sequence ID" value="XM_035459850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LMB8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010748.1">
        <property type="protein sequence ID" value="ENSCGRP00001006809.1"/>
        <property type="gene ID" value="ENSCGRG00001009262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756462"/>
    <dbReference type="KEGG" id="cge:100756462"/>
    <dbReference type="CTD" id="92126"/>
    <dbReference type="GeneTree" id="ENSGT00390000006522"/>
    <dbReference type="OMA" id="WVITEEM"/>
    <dbReference type="OrthoDB" id="5946629at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047757">
        <property type="term" value="F:chondroitin-glucuronate 5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050654">
        <property type="term" value="P:chondroitin sulfate proteoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050655">
        <property type="term" value="P:dermatan sulfate proteoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.100:FF:000001">
        <property type="entry name" value="dermatan-sulfate epimerase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.70:FF:000001">
        <property type="entry name" value="dermatan-sulfate epimerase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052447">
        <property type="entry name" value="Dermatan-Sulfate_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15532:SF2">
        <property type="entry name" value="DERMATAN-SULFATE EPIMERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678577" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="11">
        <location>
            <begin position="848"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027273679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027273680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035301287.1"/>
        </source>
    </evidence>
    <sequence length="1207" mass="138744" checksum="191102ABFD888B04" modified="2022-01-19" version="1">MALMFTGYFLFLTLMIFIFSTCEESVSNFSGWAVFTDDTEQFKNQKVQDFRSNQKLHPNLYFDAGDIQTMRQKSRTSHLHLFRAIRSAVTIMLSNPTYYLPPPKHADFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVLEYMDRMVSYKDWLVENAPGDEVPVGHSLTGFATAFDFLYNLLGNQRKQKYLEKIQIVTEEMYEYSKIRSWGKQLLHNHQATNMIALLIGALVTGIDKGSKTNIWKQDVVDVMEKTMFLLNHIVDGSLDEGVAYGSYTSKSVTQYVFLAQRHFNINNLDNNWLKMHFWFYYATLLPGYQRTVGVADSNYNWFYGPESQLVFLDKFILRNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWYDPKLTPQPPVDFGTAKMHTFPNWGVVTYGAGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKFSHLNNVLVFAPSPSSQCNKPWEGQLGECAQWLKWTGEEAGDAAGEVITASQHGEMMFVSGEAVSAYSSAMRLKSVYRALLLLNSQTLLVVDHIERQETSPINSVSAFFHNLDIDFKYIPYRFMNRYNGAMMDVWDAHYKMFWFDHHGNTPVANIQEAEQAAEFKKRWTQFVNVTFHMESTITRIAYVFYGPYINVSSCRFIDSSSSGLQISLNVNNTEHSVSVVTDYQNLKSRFDYLGFGGFASVANQGQITRFGLGTQALVNPVRHDTVIFPFGFKFNIAVGFILCISLVILTFQWWFYLSFRKLMRCVLILVIALWFIELLDVWSTCTQPICAKWTRTESKANEKTLISEGKHVDLPDVVITSLPGSGAEILKQLFFNSSDFLYIRIPTAYIDIPETEFEIDSFVDACEWKVSDIHTGHFHLLRGWLLSLVQDTKLHLQNIHLHETSRNKLAQYFAANKDKKRKLKRRESLQEQRSRMKGAFDRDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGTSMRALYIIRDPRAWIYSMLYGSKPSLYSLKNVPEHLAKLFKIQEGKSKCSLNSGYAFEYESLKKELETSQSNTVSLLSHLWLANTAAAMRINTDLLPTSYQLVKFEDIVHFPQKTTERIFAFLGIPLSPASLNQILFATSTNLFYLPYEGEISPSNTNIWKQNLPRDEIKLIESICWTLMDRLGYPKFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LQZ5</accession>
    <name>A0A8C2LQZ5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Target of rapamycin complex 2 subunit MAPKAP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Stress-activated map kinase-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29 32 33" type="primary">Mapkap1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32 33" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32 33">17A/GY</strain>
            <tissue evidence="32 33">Liver</tissue>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="23">Component of the mechanistic target of rapamycin complex 2 (mTORC2), consisting in two heterotretramers composed of MTOR, MLST8, RICTOR and MAPKAP1/SIN1. The mTORC2 core complex associates with PRR5/PROTOR1 and/or PRR5L/PROTOR2. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with MAP3K2. Interacts with ATF2. Interacts with MAPK8. Interacts with GTP-bound HRAS and KRAS; inhibiting their activity. Interacts with IFNAR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Late endosome membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Lysosome membrane</location>
            <topology evidence="21">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279529.1">
        <property type="nucleotide sequence ID" value="XM_027423728.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279530.1">
        <property type="nucleotide sequence ID" value="XM_027423729.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LQZ5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011042.1">
        <property type="protein sequence ID" value="ENSCGRP00001007041.1"/>
        <property type="gene ID" value="ENSCGRG00001009499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755792"/>
    <dbReference type="KEGG" id="cge:100755792"/>
    <dbReference type="CTD" id="79109"/>
    <dbReference type="GeneTree" id="ENSGT00390000000642"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140767">
        <property type="term" value="F:enzyme-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13331">
        <property type="entry name" value="PH_Avo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000585">
        <property type="entry name" value="target of rapamycin complex 2 subunit MAPKAP1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057339">
        <property type="entry name" value="RBD_SIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032679">
        <property type="entry name" value="Sin1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25322">
        <property type="entry name" value="RBD_SIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05422">
        <property type="entry name" value="SIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="19" id="KW-0458">Lysosome</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sin1 N-terminal" evidence="25">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CRIM" evidence="26">
        <location>
            <begin position="139"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Target of rapamycin complex 2 subunit MAPKAP1-like Ras-binding" evidence="28">
        <location>
            <begin position="287"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="27">
        <location>
            <begin position="382"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00014183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF05422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF25322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027279529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_027279530.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59037" checksum="3EC6B8FA811134B4" modified="2022-01-19" version="1">MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKTHPPSVPGDSGSEVQGSSGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELRSLFEKKSLKEKPPSLGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEKQSEPNIAVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAVFKLTYLSGHDYKHLYFESDAATVSEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LWZ1</accession>
    <name>A0A8C2LWZ1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 39 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Zrt- and Irt-like protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Slc39a11</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003495737.1">
        <property type="nucleotide sequence ID" value="XM_003495689.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281580.1">
        <property type="nucleotide sequence ID" value="XM_027425779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LWZ1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012885.1">
        <property type="protein sequence ID" value="ENSCGRP00001008743.1"/>
        <property type="gene ID" value="ENSCGRG00001010962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753680"/>
    <dbReference type="CTD" id="201266"/>
    <dbReference type="OMA" id="MIFVVIE"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027281580.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="34946" checksum="29F4BE363688AF0B" modified="2022-01-19" version="1">MLQGYSSVFQALLGTFFTWAMTAAGAALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTALALNLDPALMKKKSDPEGPTTLLLPERELSIRIDKSENGEVHQRKKMAVAGLPEGTVPSGPVQGNPGQTGVSSWRRIALLILAITLHNVPEGLAVGVGFGAVEKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPVLPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASWASILGFVVMMSLDVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LX11</accession>
    <name>A0A8C2LX11_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">G-protein-signaling modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Activator of G-protein signaling 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Gpsm1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GPSM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007649625.2">
        <property type="nucleotide sequence ID" value="XM_007651435.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278739.1">
        <property type="nucleotide sequence ID" value="XM_027422938.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LX11"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015167.1">
        <property type="protein sequence ID" value="ENSCGRP00001010939.1"/>
        <property type="gene ID" value="ENSCGRG00001012682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758972"/>
    <dbReference type="KEGG" id="cge:100758972"/>
    <dbReference type="CTD" id="26086"/>
    <dbReference type="GeneTree" id="ENSGT00940000154667"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000192">
        <property type="entry name" value="G-protein-signaling modulator 1 isoform a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000145">
        <property type="entry name" value="G-protein-signaling modulator 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000043">
        <property type="entry name" value="G-protein-signaling modulator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF2">
        <property type="entry name" value="G-PROTEIN-SIGNALING MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="15" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 21" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="21">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="420"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="644"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027278739.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="74447" checksum="656CB4943ED00804" modified="2022-01-19" version="1">MASPAPPAADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKAGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEYSRALQFHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAAQDPGHLPPDVRETLHRASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDRNGELTARMNIAQLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDREQNGDTHHTGDWRGPGRDSLPLPMRSRKYQEGVDTTERRPREGSHSPLDSADVRVQVPRTGIPRAPSSDEECFFDLLSKFQSSRMDDQRCPLEEGQAGAAEATAAPALEERAAQPSVTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITLNNVGHLRGDGDPQEPGDEFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGSPEQEASGLHEPRQQCPPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M0V3</accession>
    <name>A0A8C2M0V3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-FMRFamide-related neuropeptide VF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Npvf</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion. Induces secretion of prolactin.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003498609.2">
        <property type="nucleotide sequence ID" value="XM_003498561.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285555.1">
        <property type="nucleotide sequence ID" value="XM_027429754.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M0V3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016298.1">
        <property type="protein sequence ID" value="ENSCGRP00001012065.1"/>
        <property type="gene ID" value="ENSCGRG00001013575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759879"/>
    <dbReference type="KEGG" id="cge:100759879"/>
    <dbReference type="CTD" id="64111"/>
    <dbReference type="GeneTree" id="ENSGT00390000003271"/>
    <dbReference type="OMA" id="KMPHSVA"/>
    <dbReference type="OrthoDB" id="8834619at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160041">
        <property type="term" value="F:neuropeptide activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032277">
        <property type="term" value="P:negative regulation of gonadotropin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026297">
        <property type="entry name" value="FMRFamide-related/fGRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14403:SF6">
        <property type="entry name" value="PRO-FMRFAMIDE-RELATED NEUROPEPTIDE VF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14403">
        <property type="entry name" value="RFAMIDE PEPTIDE GONADOTROPIN INHIBITORY HORMONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0027">Amidation</keyword>
    <keyword evidence="7 15" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678699" description="Pro-FMRFamide-related neuropeptide VF" evidence="11">
        <location>
            <begin position="27"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027285555.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21355" checksum="A2B60C3462907630" modified="2022-01-19" version="1">MEIISSKRFILLTLATSSLLTSNIFCTDELMVPHCHSKEKDGKYSQPRGIPKGEKERSVTFQELKDWGAKNVIKMSPAPANKVPHSAANLPLRFGRTLEEERSPRARANMEAMTLSRVPSLPQRFGRTTARSIPKTLSHLLQRSLHSLATSELLYAMTCQHQEIQSPDGKQARRQAFMETDDEEGKHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M6Z6</accession>
    <name>A0A8C2M6Z6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Alpha-aminoadipic semialdehyde synthase, mitochondrial</fullName>
            <ecNumber evidence="6">1.5.1.8</ecNumber>
            <ecNumber evidence="7">1.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">LKR/SDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26 27" type="primary">Aass</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26 27">17A/GY</strain>
            <tissue evidence="26 27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Bifunctional enzyme that catalyzes the first two steps in lysine degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24520"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="EC" id="1.5.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19373"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.8"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:19375"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.8" evidence="6"/>
    <dbReference type="EC" id="1.5.1.9" evidence="7"/>
    <dbReference type="RefSeq" id="XP_007643548.1">
        <property type="nucleotide sequence ID" value="XM_007645358.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245778.1">
        <property type="nucleotide sequence ID" value="XM_027389977.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245779.1">
        <property type="nucleotide sequence ID" value="XM_027389978.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027294086.1">
        <property type="nucleotide sequence ID" value="XM_027438285.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M6Z6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017063.1">
        <property type="protein sequence ID" value="ENSCGRP00001012828.1"/>
        <property type="gene ID" value="ENSCGRG00001014114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751161"/>
    <dbReference type="KEGG" id="cge:100751161"/>
    <dbReference type="CTD" id="10157"/>
    <dbReference type="GeneTree" id="ENSGT00390000013249"/>
    <dbReference type="OMA" id="TPHVHDI"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
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    </dbReference>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
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    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="22">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="21">
        <location>
            <begin position="197"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00025744"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00051926"/>
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            <dbReference type="SMART" id="SM01003"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
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    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027245779.1"/>
        </source>
    </evidence>
    <sequence length="923" mass="102528" checksum="844C293C0C9F10D0" modified="2022-01-19" version="1">MLRVQRPRLVRLRACLSRGLHHKPVMALRREDVNAWERRAPLAPKHIKGITKLGYKVLIQPSNRRAIHDKEYARAGGILQEDITEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMSLLDQVLKQEIRLIDYEKMVDHRGSRIVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEVFNELPCEYVEPHELKEVSKTGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYEKYPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAKSLLAPVKSAVVPVEGCPELPHKLVAICDISADTGGSIDFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVITSNGILTDKYKYIQKLRESRERIQFLSMSTKKKVLVLGSGYVSGPVLEYLSRDNKIEITVGSDMTNQMQQLSKKYNINPVSVTIGKQEEKLQSLIASQDLVISLLPYALHPVVAKACISNRVNMITASYITPAMKELEKSVDDAGITIIGELGLDPGLDHMLAMETIDKAKELGATIESYVSYCGGLPAPECSDNPLRYKFSWSPVGVLMNVMQPASYLLNGEVVNVTGGVSFLDSVAPMDYFPGLNLEGYPNRDSIRYAEIYGIPSAHTLLRGTLRYKGYSKALNGFVKLGLINREALRPEANPLTWKQLLCDLVGISRSSSCETLKEAVFSKLGGDSTQLEAAEWLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRDSFGIRHPSGHLENKIIDLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIEAKGLMGPFTKEIYGPILERIRAEGIVFNTQSTIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MIY9</accession>
    <name>A0A8C2MIY9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA binding motif protein 6</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11 12 13">RNA-binding protein 6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11 12 13 14" type="primary">Rbm6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11 12 13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11 12 13">17A/GY</strain>
            <tissue evidence="11 12 13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003500460.1">
        <property type="nucleotide sequence ID" value="XM_003500412.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639298.1">
        <property type="nucleotide sequence ID" value="XM_007641108.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639299.1">
        <property type="nucleotide sequence ID" value="XM_007641109.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639300.1">
        <property type="nucleotide sequence ID" value="XM_007641110.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270297.1">
        <property type="nucleotide sequence ID" value="XM_027414496.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270298.1">
        <property type="nucleotide sequence ID" value="XM_027414497.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270299.1">
        <property type="nucleotide sequence ID" value="XM_027414498.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270300.1">
        <property type="nucleotide sequence ID" value="XM_027414499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MIY9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024138.1">
        <property type="protein sequence ID" value="ENSCGRP00001019894.1"/>
        <property type="gene ID" value="ENSCGRG00001019202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755843"/>
    <dbReference type="KEGG" id="cge:100755843"/>
    <dbReference type="CTD" id="10180"/>
    <dbReference type="GeneTree" id="ENSGT00940000157976"/>
    <dbReference type="OMA" id="RNIPHAD"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12314">
        <property type="entry name" value="RRM1_RBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12563">
        <property type="entry name" value="RRM2_RBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.80:FF:000004">
        <property type="entry name" value="RNA-binding motif protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000304">
        <property type="entry name" value="RNA-binding protein 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034123">
        <property type="entry name" value="RBM6_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034125">
        <property type="entry name" value="RBM6_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF22">
        <property type="entry name" value="RNA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="456"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    <sequence length="1119" mass="128337" checksum="188571FB9D319269" modified="2022-01-19" version="1">MWGDSRSANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGPHGDYQGGEGPGHDFRGGDFSSSDFQSRDSAQLDFRNRDMHSGDFRDREGPPMDYRGGDGTPMDYRGRETPHMNYRDRDSHPIDFRSRDVPPSDFRGRGTYDLDFRGRDGSHADFRGRDLSDLDFRSRDQSRSDFRNRDVSDLDLRDKEGTQVDFRGRGSATTDLDFRSRDAAHSDFRGRHRSRTYQDFRGREVGPCMEFKDREMPPVDPKILDYIQPSTQEREHSGVNVNKREEPTHDHAMEMAAFGVQKGEFEHSETREGETQSGTFEHESPSDFQNSQSPVQDQDKPKLPGGEQQSSDAGLFKEEGDLDFLGRQDTDYRNIEYCDVDHRLPGSQIFGYGQNKSFPQGKMSRDAQQELQDQDYRTGPSEEKPNRLIRLSGVPKNATKEEILNAFRTSDGIPVKELQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQGTLMIHDKEVTLEYVPSPDFWYCKRCKASTGGHQSSCSFCKGPKEEVKQELVSYPQPQKTSIPVPSEKQPNQPRPADKEHEFRKREEGQESRSGHQKRDSERYFPHSRREGLTFRRDREKESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVHLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGNRNSDWSSDTNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPESPEEEESKEKKSTSQGKSSSKKETSKRDSKEKKDRGVTKFQESTSEGKSPPEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQAPPVQLRTAQPQQREELTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGRFKERGNDRREKLQSFDSPERKRIKYSRETDSDRNPVDKEDTDTNSKGGCAQQAAGWRKGTGLGYSHPGLGSSEETEGRMRGPGGAPGRTSKRQSNETYRDAVRRVMFARYKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJ34</accession>
    <name>A0A8C2MJ34_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D</fullName>
            <ecNumber evidence="8">3.1.4.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="42 45" type="primary">Napepld</name>
    </gene>
    <organism evidence="42 43">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="44" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="44">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="44" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="44">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="45" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="45">17A/GY</strain>
            <tissue evidence="45">Liver</tissue>
        </source>
    </reference>
    <reference evidence="42" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56464"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:138663"/>
            <dbReference type="ChEBI" id="CHEBI:140452"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:56465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85291"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:45533"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>N,1-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1-acyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52640"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:85216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:53165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85334"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:45597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45592"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:85335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:45593"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45528"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85277"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:45529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56548"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:140532"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:56549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45544"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:45545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-butanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45620"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85298"/>
            <dbReference type="ChEBI" id="CHEBI:85304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:45621"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-decanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85295"/>
            <dbReference type="ChEBI" id="CHEBI:85301"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:45609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-dodecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85263"/>
            <dbReference type="ChEBI" id="CHEBI:85294"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:45557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45540"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:78097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:45541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45616"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85297"/>
            <dbReference type="ChEBI" id="CHEBI:85303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:45617"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octadecanoyl ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45536"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85292"/>
            <dbReference type="ChEBI" id="CHEBI:85299"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:45537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72860"/>
            <dbReference type="ChEBI" id="CHEBI:85296"/>
            <dbReference type="ChEBI" id="CHEBI:85302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:45613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-tetradecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85262"/>
            <dbReference type="ChEBI" id="CHEBI:85293"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:45553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52640"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
            <dbReference type="EC" id="3.1.4.54"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:33160"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NAPE-PLD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.54" evidence="8"/>
    <dbReference type="RefSeq" id="XP_027249231.1">
        <property type="nucleotide sequence ID" value="XM_027393430.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MJ34"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023834.1">
        <property type="protein sequence ID" value="ENSCGRP00001019590.1"/>
        <property type="gene ID" value="ENSCGRG00001018986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759349"/>
    <dbReference type="KEGG" id="cge:100759349"/>
    <dbReference type="CTD" id="222236"/>
    <dbReference type="GeneTree" id="ENSGT00390000017990"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098686">
        <property type="term" value="C:hippocampal mossy fiber to CA3 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030868">
        <property type="term" value="C:smooth endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032052">
        <property type="term" value="F:bile acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048874">
        <property type="term" value="P:host-mediated modulation of intestinal microbiota composition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090336">
        <property type="term" value="P:positive regulation of brown fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001659">
        <property type="term" value="P:temperature homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000016">
        <property type="entry name" value="N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0595">Phospholipid degradation</keyword>
    <keyword evidence="21" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="44" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="41">
        <location>
            <begin position="214"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="40">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="40">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="40">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="40">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00016017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00049023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00049463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00051257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="RefSeq" id="XP_027249231.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="53147" checksum="33E90E7109D6823D" modified="2022-01-19" version="1">MARRRALTRCVQLWARSAEQGRRRGGRRSAGRGLCGTSGAAWPAASWASAEGTPRHARSLALRTSFSPKDMDENENSQSSTTSYQYPKETVRKRQNSVQNSGGSVSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNISISNVFRWLIMEKDHSSVPVSKEELDKELPVLKPYFISDPKEAGVTEAGLRVTWLGHATLMVEMDELIFLTDPMFSSRASPSQYMGPKRFCGPPCTISELPPIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWSKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEDAVRIHIDVQTKKSVAIHWGTFALANEHYLEPPVKLNEALERYGLKSEDFFVLKHGESRYLNNDKAFEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJ97</accession>
    <name>A0A8C2MJ97_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4">Melanoregulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">Mreg</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">17A/GY</strain>
        </source>
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        <source>
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        <source>
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    <sequence length="214" mass="25059" checksum="0A7A89514745376C" modified="2022-01-19" version="1">MGLRRWLRSACCCCPCRCLEEPARPEKEPLVSDSNLYSSFGATLERDDEKNLWSMPHDVSHTEADDDRILYNLIVIRNQQTKDSEEWQRLNYDIYSLRQIRREVRNRWRRILEDLGFQREADSLLSVTKLSTMSDSKNTRKAREMLLKLAEETTIFPASWELSERYLLVVDRLIALDAAEEFFKIASRTYPKKPGVPCLGDGQKKLHYLPFPSP</sequence>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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                <person name="Samoudi M."/>
                <person name="Hao H."/>
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                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
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            <authorList>
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            <strain evidence="6">17A/GY</strain>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <accession>A0A8C2MN26</accession>
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                <person name="Dhiman H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">17A/GY</strain>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <source>
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    </evidence>
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    </evidence>
    <sequence length="249" mass="28007" checksum="035A143A92FA1A49" modified="2022-01-19" version="1">MGARAFQEPQAPPGLRLLLLFLLLMLLALVAPGAQGARGRGTADKNSHRRAASTFSQSVNSLFGEDNVRAAQKLLSRLTERFVQGVDMFMETIWKVWMELLEVLGLDVSNLSQYFSPASVSNNPTRALVLVGVVLLAYWFLSLTLGFTFSFLHLVFGRFFWLVRVILFSMSCVYILHKYEGEPEHTVLPLCLVVAIYFMTGPMGYWRGSPGGLGSPSVEEKLEHLENQVRLLNIRLNRVLENLDRSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MX24</accession>
    <name>A0A8C2MX24_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-B-cell leukemia transcription factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17 18">Homeobox protein PBX1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Pbx1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a heterodimer with MEIS1 which binds DNA. The PBX1-MEIS1 heterodimer binds a cAMP-responsive sequence in CYP17. It also binds a consensus region in the SOX3 promoter. PBX1 forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Forms heterodimers with HOXA1, HOXA5, HOXB7 and HOXB8 which bind the 5'-TGATTGAT-3' consensus sequence. Also forms heterodimers with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 which bind the 5'-ATCAATCAA-3' consensus sequence. Interacts with PBXIP1. Interacts with TLX1. Interacts with FOXC1. Interacts with MN1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Part of a PDX1:PBX1b:MEIS2B complex; PBX1b recruits MEIS2B to the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/PBX homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016831969.2">
        <property type="nucleotide sequence ID" value="XM_016976480.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272892.1">
        <property type="nucleotide sequence ID" value="XM_027417091.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MX24"/>
    <dbReference type="SMR" id="A0A8C2MX24"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028571.1">
        <property type="protein sequence ID" value="ENSCGRP00001024325.1"/>
        <property type="gene ID" value="ENSCGRG00001022276.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772263"/>
    <dbReference type="KEGG" id="cge:100772263"/>
    <dbReference type="CTD" id="5087"/>
    <dbReference type="GeneTree" id="ENSGT00940000154374"/>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030325">
        <property type="term" value="P:adrenal gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035162">
        <property type="term" value="P:embryonic hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001779">
        <property type="term" value="P:natural killer cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000648">
        <property type="term" value="P:positive regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030278">
        <property type="term" value="P:regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072089">
        <property type="term" value="P:stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001655">
        <property type="term" value="P:urogenital system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000277">
        <property type="entry name" value="Pre-B-cell leukemia transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005542">
        <property type="entry name" value="PBX_PBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03792">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51978">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 19" id="KW-0371">Homeobox</keyword>
    <keyword evidence="11 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="12" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PBC" evidence="22">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="21">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="19">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027272892.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="46626" checksum="AD3FFACBC5A9E715" modified="2022-01-19" version="1">MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MZB0</accession>
    <name>A0A8C2MZB0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Equilibrative nucleoside transporter 1 isoform X5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Solute carrier family 29 (nucleoside transporters), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13 14" type="primary">LOC100754792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14">17A/GY</strain>
            <tissue evidence="13 14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027243208.1">
        <property type="nucleotide sequence ID" value="XM_027387407.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308577.1">
        <property type="nucleotide sequence ID" value="XM_035452686.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311247.1">
        <property type="nucleotide sequence ID" value="XM_035455356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MZB0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030483.1">
        <property type="protein sequence ID" value="ENSCGRP00001026237.1"/>
        <property type="gene ID" value="ENSCGRG00001023604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754792"/>
    <dbReference type="GeneTree" id="ENSGT00950000182898"/>
    <dbReference type="OMA" id="KIMFINS"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015207">
        <property type="term" value="F:adenine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015212">
        <property type="term" value="F:cytidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015208">
        <property type="term" value="F:guanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015211">
        <property type="term" value="F:purine nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015389">
        <property type="term" value="F:pyrimidine- and adenosine-specific:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015210">
        <property type="term" value="F:uracil transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015213">
        <property type="term" value="F:uridine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032238">
        <property type="term" value="P:adenosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046032">
        <property type="term" value="P:ADP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035344">
        <property type="term" value="P:hypoxanthine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035340">
        <property type="term" value="P:inosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001504">
        <property type="term" value="P:neurotransmitter uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035364">
        <property type="term" value="P:thymine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034764">
        <property type="entry name" value="ENT1/ENT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00939">
        <property type="entry name" value="2a57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF9">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027243208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035308577.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50283" checksum="F14DFE4070596E07" modified="2022-01-19" version="1">MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDLYQNVSSATDKPSKDTEALPAPTVTLPERSPLSAIFSNVMTLCAMLPLLLFTCLNSFLHQRISQSVRILGSLVAILLVFLITAILVKVEVDALTFFIITMIKIVLINSFGAVLQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMICAIASGSKLSESAFGYFITACVFVILAIVCYLALPRLEFYRYYLQLNLEGPSDQETKLDLISKGEEPRGGREESGVPARSSPPSSKNHSIKAILKNISVLALSVCFIFTVTIGLFPAVTTEVESSIAGTSAWKSYYFIPVACFLNFNVFDWLGRSLTAICMWPGKDSLWLPVLVVSRIVFIPLLLLCKVKHRYYLRSIFTHDAWFIIFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLALGAVLSFLLRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N7B3</accession>
    <name>A0A8C2N7B3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thrombospondin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Thbs2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035296344.1">
        <property type="nucleotide sequence ID" value="XM_035440453.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312806.1">
        <property type="nucleotide sequence ID" value="XM_035456915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N7B3"/>
    <dbReference type="SMR" id="A0A8C2N7B3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030284.1">
        <property type="protein sequence ID" value="ENSCGRP00001026038.1"/>
        <property type="gene ID" value="ENSCGRG00001023457.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752022"/>
    <dbReference type="KEGG" id="cge:100752022"/>
    <dbReference type="CTD" id="7058"/>
    <dbReference type="GeneTree" id="ENSGT00940000157846"/>
    <dbReference type="OMA" id="MPGVMLQ"/>
    <dbReference type="OrthoDB" id="14563at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031091">
        <property type="term" value="C:platelet alpha granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000004">
        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000009">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000070">
        <property type="entry name" value="Thrombospondin 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thrombospondin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000003">
        <property type="entry name" value="Thrombospondin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000025">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000001">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017897">
        <property type="entry name" value="Thrombospondin_3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008859">
        <property type="entry name" value="Thrombospondin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199">
        <property type="entry name" value="THROMBOSPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199:SF10">
        <property type="entry name" value="THROMBOSPONDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05735">
        <property type="entry name" value="TSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51234">
        <property type="entry name" value="TSP3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51236">
        <property type="entry name" value="TSP_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679149" description="Thrombospondin-2" evidence="15">
        <location>
            <begin position="19"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="17">
        <location>
            <begin position="318"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="549"/>
            <end position="589"/>
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    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="648"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="13">
        <location>
            <begin position="729"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="13">
        <location>
            <begin position="788"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="13">
        <location>
            <begin position="885"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="13">
        <location>
            <begin position="921"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="TSP C-terminal" evidence="18">
        <location>
            <begin position="960"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="727"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="846"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="925"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QFT0</accession>
    <name>A0A8C2QFT0_CRIGR</name>
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        </submittedName>
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        <name evidence="10" type="synonym">Kiaa0895</name>
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    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_007647728.1">
        <property type="nucleotide sequence ID" value="XM_007649538.2"/>
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        <property type="nucleotide sequence ID" value="XM_027411672.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSCGRP00001009063.1"/>
        <property type="gene ID" value="ENSCGRG00001011224.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100768942"/>
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    <dbReference type="GeneTree" id="ENSGT00390000004417"/>
    <dbReference type="OMA" id="CNHEIGT"/>
    <dbReference type="OrthoDB" id="449345at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012548">
        <property type="entry name" value="MATCAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817:SF3">
        <property type="entry name" value="TYROSINE CARBOXYPEPTIDASE MATCAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08014">
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
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        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027267473.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="59685" checksum="C50485F2B83A172B" modified="2022-01-19" version="1">MLESIRVTEKLHWPEHELAKKSVLNAEEQLIIDSKRSFSSLSSGVLKDTFTTGTSSYNVLLQTKEERKHHSQKQFSSTFSKRRRKPSKSPSSSNILKDPHRMTALVPVTSTGTWYCLDRQSAVFIGNSVPSPLKFTHDISVTGSSLALPPKPKSKVKCRSVTPLPKPKQQPQLCRSFEKGDDLSGKKLCILTAIKPINLEKEKLRFFKSDYTYNPQFEYANPALPGVLAKYSNASDRFLKQSIKIMELTLQKYGSYEKFEQATGGSLLTKTRIWSHVRKYMLKEGCLGEIVVHLTEDLLSRASMTVVNGCPTLTINISTAREHWLEGMLRHEIGTHYFRAVNNLQQPWNSWPGRKKHELKPNNPTEEGLASIHSVLFRKDPFLWRAALLYYTVYQASQMSFCELFKDIGKFVQDPNTRWDYCVRAKRGWTDTSQPGCFSKDQVYLDGILQILRFRDSIDFHLLTALGKVSYEDVDRLKELAVTENMRVPHFLHDHSRYMEHLEKIMEVNELTDAELKALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QGX9</accession>
    <name>A0A8C2QGX9_CRIGR</name>
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            <fullName evidence="1">RAB6A GEF compex partner 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4 5">RAB6A-GEF complex partner protein 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 4 5" type="primary">Rgp1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4 5">17A/GY</strain>
            <tissue evidence="4 5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="1" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027259035.1">
        <property type="nucleotide sequence ID" value="XM_027403234.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259036.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QGX9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015668.1">
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    </dbReference>
    <dbReference type="GeneID" id="100755470"/>
    <dbReference type="KEGG" id="cge:100755470"/>
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    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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            <dbReference type="Ensembl" id="ENSCGRP00001011436.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027259035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027259036.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="42526" checksum="711A114CF428EEEA" modified="2022-01-19" version="1">MIEVVAELSRGPVFLAGEALECLVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPDSQTVFLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPTEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVHFPQDEAVAPSSPFLEEDESGKKDSWLAELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGTGVAPSVSHVTHARHQESCLHTARTSFSLPIPLCSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPLEQPEPSTWTGPEQVPVDTFSWDLPIKVLPTSPTLVSYAAPGPSTTSITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QME8</accession>
    <name>A0A8C2QME8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat and transmembrane domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Lrtm2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035304819.1">
        <property type="nucleotide sequence ID" value="XM_035448928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QME8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026600.1">
        <property type="protein sequence ID" value="ENSCGRP00001022355.1"/>
        <property type="gene ID" value="ENSCGRG00001020923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752413"/>
    <dbReference type="KEGG" id="cge:100752413"/>
    <dbReference type="CTD" id="654429"/>
    <dbReference type="GeneTree" id="ENSGT00940000157572"/>
    <dbReference type="OrthoDB" id="1600340at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000576">
        <property type="entry name" value="Leucine rich repeats and transmembrane domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF175">
        <property type="entry name" value="LEUCINE RICH REPEATS AND TRANSMEMBRANE DOMAINS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="13">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035304819.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41037" checksum="DBDD1985C022ABFA" modified="2022-01-19" version="1">MLAPGSGPEQRSKLALQWRQVAWITCWIALCAVEVLPACPFSCICDSRSLEVDCSGLGLTTVPPDVPAATQSLLLLNNKLSALPSWAFANLSNLQRLDLSNNFLDQLPRSIFQDLVNLTELQLRNNSIRTLDRDLLQHAPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQSLDRLTFEPLASLQLLQVGDNPWECDCNLREFKHWLEWFSYRGGRLDQLACTLPKELRGKDMRAVPMEMFNYCSQLEDENNSAGMDAPGPPCTKASPEPAKPKPGPEPEPEPSTACPQKQRYRPVSVRRAIGTVIIAGVVCGIVCIMMVVAAAYGCIYASLMAKYHRELKKRQPLMGDPEGEHEDQKQISSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F073</accession>
    <name>A0A9J7F073_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transmembrane protein 258</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100755652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027247058.1">
        <property type="nucleotide sequence ID" value="XM_027391257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F073"/>
    <dbReference type="GeneID" id="100755652"/>
    <dbReference type="KEGG" id="cge:100755652"/>
    <dbReference type="OrthoDB" id="18408at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13636">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027247058.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9124" checksum="5EC51532F5DFCF1E" modified="2023-06-28" version="1">MELQAMSRYTSLVNPAVFPHLTVVLLAISMFFIAWFFIYKVTSTEYTCDIYKEHPISLVASLFMDFGVLFFLLLVGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F117</accession>
    <name>A0A9J7F117_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCNA-interacting partner</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PARP-1 binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PARP1-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Parpbp</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with RAD51 and PCNA. Interacts with PARP1. Interacts with TASOR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PARI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027248358.1">
        <property type="nucleotide sequence ID" value="XM_027392557.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F117"/>
    <dbReference type="GeneID" id="100770705"/>
    <dbReference type="KEGG" id="cge:100770705"/>
    <dbReference type="CTD" id="55010"/>
    <dbReference type="OrthoDB" id="6427080at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.486.10:FF:000004">
        <property type="entry name" value="PCNA-interacting partner isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038932">
        <property type="entry name" value="PARPBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32121">
        <property type="entry name" value="PCNA-INTERACTING PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32121:SF0">
        <property type="entry name" value="PCNA-INTERACTING PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027248358.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="64174" checksum="69E8FD5F03AFCE11" modified="2023-06-28" version="1">MAVLNQMSVLGMIKEFRRNWRAHCNSERTTLCGPDSMLLALQLSMAENNKQHNGEFTVSLSDVLLTWKYFLHEKLNLPTESVKVVDHYEDIKKTYDDFLKNSNMLDLIDVYEKCSNLTSNCENSIISSSQLRDFLSGTQCAVNDETNPQIPVSPVKCNQHEQMRLLAKKIFFSYLGLLVNSKNDLALAHVLNIPDRGLGREAFTDLKHAAREKQLSMFLMATSFIRTLELGGKGYAPSPSDPLRAHAKGLSDFISFIDKLDEILGETPNPSLAGGRILSVIKMRLIKGHSSGDPFYKAVEEVVQDLDLRIKNIINSQESVTVSTTNISPVPPKSFAINHDTAYCGRDAVKILLVLLDEDAASAPTRNRAELLYNDESTVPHNGTSILTLFRSPTQVNNTSIKPLKERICKSVQAEKNKMRQTLIRSQFACTYKDDYIMSKNKWNVNLSSKPLHVLHLENDVSEGAHSSVGRARIERSSENVHLDGSKDDKIPRKSTENKISKRKQVDLDSNNIHCENGNELYQHTNFKFPKVSNDSHNKAGGKLARGAKGNRCTAKDKLIPGQTKLTQFFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F550</accession>
    <name>A0A9J7F550_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CCR4-NOT transcription complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CCR4-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC100755143</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027248165.1">
        <property type="nucleotide sequence ID" value="XM_027392364.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F550"/>
    <dbReference type="SMR" id="A0A9J7F550"/>
    <dbReference type="GeneID" id="100755143"/>
    <dbReference type="KEGG" id="cge:100755143"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000001">
        <property type="entry name" value="Putative CCR4-NOT transcription complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="17">
        <location>
            <begin position="407"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="286"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027248165.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="60906" checksum="E9840E6F559CAF2B" modified="2023-06-28" version="1">MRTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYGQQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSLSSNIFNGTDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FBF3</accession>
    <name>A0A9J7FBF3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inositol polyphosphate 1-phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC100755639</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Signal transduction; phosphatidylinositol signaling pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="12"/>
    <dbReference type="RefSeq" id="XP_027252645.1">
        <property type="nucleotide sequence ID" value="XM_027396844.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252646.1">
        <property type="nucleotide sequence ID" value="XM_027396845.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252647.1">
        <property type="nucleotide sequence ID" value="XM_027396846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FBF3"/>
    <dbReference type="GeneID" id="100755639"/>
    <dbReference type="KEGG" id="cge:100755639"/>
    <dbReference type="OrthoDB" id="9977309at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01640">
        <property type="entry name" value="IPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000015">
        <property type="entry name" value="Inositol polyphosphate 1-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.460.10:FF:000001">
        <property type="entry name" value="Inositol polyphosphate 1-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.460.10">
        <property type="entry name" value="Inositol Polyphosphate 1-phosphatase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044897">
        <property type="entry name" value="INPP1_dom_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF3">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 1-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0452">Lithium</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027252645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027252646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027252647.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43898" checksum="85D492E76A6D9E4E" modified="2023-06-28" version="1">MSDILKELLRVSEKAANIARACRQQETLFQLLIQEKKDEEKNKKFATDFKTLADVLVQEVIKQNMENKFPGLGKKILGEESNEFTNDLGEKITVELQSTEEETAELLSRVLNGNMLASEALAKVVHQDVDLTDPSLEALEISIPQDILGIWVDPIDSTYQYIKGSANVKSNQGVFPNGLQCVTILIGVYDIQTGMPLMGVINQPFVSQNLTTLRWKGQYYWGLSYMGTNIHSLQFSIPKGNNSETHTENSDLEFSRPFSAVISTSEKETIKAAMSRICEGGVFSAAGAGYKSLCVVQGLVDIYIFSEDTTYKWDSCAAHAILRAMGGGIVDMKECLARSPESGLDLPQLLYHMENKGASGVDLWANKGGLIAYRSRNRLDTFLSCLTQNLGPLKTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FCQ8</accession>
    <name>A0A9J7FCQ8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Natriuretic peptides A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Atrial natriuretic factor prohormone</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Atrial natriuretic peptide prohormone</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Atriopeptigen</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cardiodilatin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">preproCDD-ANF</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Nppa</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.</text>
    </comment>
    <comment type="function">
        <text evidence="5">May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.</text>
    </comment>
    <comment type="function">
        <text evidence="1">May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.</text>
    </comment>
    <comment type="function">
        <text evidence="6">May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.</text>
    </comment>
    <comment type="function">
        <text evidence="3">May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.</text>
    </comment>
    <comment type="function">
        <text evidence="20">May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.</text>
    </comment>
    <comment type="function">
        <text evidence="4">May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer; disulfide-linked antiparallel dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 21">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 21">Belongs to the natriuretic peptide family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027253980.1">
        <property type="nucleotide sequence ID" value="XM_027398179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FCQ8"/>
    <dbReference type="GeneID" id="100774350"/>
    <dbReference type="KEGG" id="cge:100774350"/>
    <dbReference type="CTD" id="4878"/>
    <dbReference type="OrthoDB" id="8865096at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051427">
        <property type="term" value="F:hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006182">
        <property type="term" value="P:cGMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000663">
        <property type="entry name" value="Natr_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030480">
        <property type="entry name" value="Natr_peptide_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050787">
        <property type="entry name" value="Natriuretic_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002407">
        <property type="entry name" value="Natriuretic_peptide_atrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14066">
        <property type="entry name" value="ATRIAL NATRIURETIC FACTOR PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14066:SF2">
        <property type="entry name" value="NATRIURETIC PEPTIDES A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00212">
        <property type="entry name" value="ANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00711">
        <property type="entry name" value="ANATPEPTIDE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00710">
        <property type="entry name" value="NATPEPTIDES"/>
    </dbReference>
    <dbReference type="SMART" id="SM00183">
        <property type="entry name" value="NAT_PEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00263">
        <property type="entry name" value="NATRIURETIC_PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0372">Hormone</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="13 21" id="KW-0838">Vasoactive</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039890895" description="Natriuretic peptides A" evidence="23">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00011384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00020078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027253980.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16784" checksum="9CAAE7226B6EE8F8" modified="2023-06-28" version="1">MGSFSIAMGFFLLLAFWLPGHIGANPVYSAVSNTDLMDFKNLLDHLEEKMPLEDEVVPPQALSEQNDEAPGAVLNSLPEVPPWTGEVNPPQREGSTLGRSSWEPSDRSALLKSKLRALLAAPRSLRRSSCFGGRIDRIGAQSGLGCNSFRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FPW7</accession>
    <name>A0A9J7FPW7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100769910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative pheromone receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027265297.1">
        <property type="nucleotide sequence ID" value="XM_027409496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FPW7"/>
    <dbReference type="GeneID" id="100769910"/>
    <dbReference type="KEGG" id="cge:100769910"/>
    <dbReference type="OrthoDB" id="9596041at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016503">
        <property type="term" value="F:pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000033">
        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027265297.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34232" checksum="BE3F8A09CD8F956D" modified="2023-06-28" version="1">MVLDPVKGTVFLCLTGIGIMGNILVFVSYVHMFQSTEKKPIHLILAHLALTNIGMLLSKGMPKTIEAFNFGNFLDDTSCKVVVYLARVSRGLSICTSSFLTMVQAITISPRHSRWQRLKLKTPQHILSSMLFFWILNSLISMNLPYYIKSINSVNITQIKRGGNYCYFVPESQITRWIFLTLMVLRDAVFQGAMGGASGYMVLLLHKHHQHVLYLQNSKLLYRTPPELRAAQSVLLLMLCFLFFYWADCFISLYFTFFIENYSKILYVPEFLTLGYAVISPFILIHRDEHLTKCCHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FUH9</accession>
    <name>A0A9J7FUH9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC113835189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="RefSeq" id="XP_027266894.1">
        <property type="nucleotide sequence ID" value="XM_027411093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FUH9"/>
    <dbReference type="GeneID" id="113835189"/>
    <dbReference type="KEGG" id="cge:113835189"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03077">
        <property type="entry name" value="GST_N_Alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000005">
        <property type="entry name" value="Glutathione S-transferase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003080">
        <property type="entry name" value="GST_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF233">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01266">
        <property type="entry name" value="GSTRNSFRASEA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027266894.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25445" checksum="B554F4035783D4CD" modified="2023-06-28" version="1">MSGKPVLHHFNGRGRVECIRWLLAAAGVEFEEKFIECPEDLEKLRKDGKLMFEQVPMVEIDGMTLVQTRAILNYIATKYDLDGKDVKERALIDMYAEGIADLSEMMGQLVVTPPDQKEAKIALIKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHLLELLLYVEEIDSSLLAPFPLLKALKSRLSNLPNVKKFLQPGSQRKPPIDEKVLEKAKKIFKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FXM4</accession>
    <name>A0A9J7FXM4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Vomeronasal type-2 receptor 116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100770554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269195.1">
        <property type="nucleotide sequence ID" value="XM_027413394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FXM4"/>
    <dbReference type="GeneID" id="100770554"/>
    <dbReference type="KEGG" id="cge:100770554"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06365">
        <property type="entry name" value="PBP1_pheromone_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000024">
        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF545">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 118-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="541"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027269195.1"/>
        </source>
    </evidence>
    <sequence length="820" mass="93550" checksum="138F7A971E9928E6" modified="2023-06-28" version="1">MIASNWYSVWYGSFPSILTKHFCRFKFKSYQCSLAFIFAIEEINRNPHLLPNTSLGFDFYNVQRSEWDFLREAFLWLTGMGINIPNYTCRRENKAVALLTGVSWATSARIGRLLNLYKYPQLSFGPFDSFLSDRSQFSSLYQTAPRDTSLFFGIVSLMIHFSWSWVGLILIDNHKGIQILSDFREEFQRNKICVAFIKMMSENMIYSDYVDEATLRLILMSSANVVIFYDDIESAHGILLHPMYLLKTWKVWVMNSQMDIGSIVDPFVFDSFHGTIYFVHHHDEISDFRKFMQTYTPSKYPEDHYLARFWNLYFNCSFSLPDCKISDNCLPNASLELLPSNMWNMDMTEEAYNMYNSVYAVAHSLHEMTLKQIQIKTHGNGVGNPNPLELHSFLKQIHFKNGAGHHVVLDSQMKLDEEYDIFNVWNFPPGFRQNIKVGTFSLKAPQGHQLFLSDHMIQWDTGFTELPSSVCSESCVPGFRKSTQEGQAICCYDCIPCPLNEISNKTDMDNCVKCPESHYANAQQTHCLEKAVTFLSYEDPLGMALSCMSLGCSVLTLGVFSVFVKHHHTPIVKANNQALTYILLMTLTFCFLCPLLFIGHPNTVTCILQQSTFAILFTVALSTVLAKTLTVVLAFKSTVTGRMVSWIMKSRAPNYIIPICSLILLVLCGIWLSTSPPFTDSDAYTEHGHIIIICNKGSTIAFHSVLGYLCSMALGNYILAYLSRNLPDTFNEAKFITFSMLVFFSVWVTFLPVYHSTKGKVMLAMEVFAILASSAGLLGFIFAPKCYILLLRPERNSLHFMKSKTHSIRNINVHLLTHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G000</accession>
    <name>A0A9J7G000_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein of 126 kDa isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cep126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027270959.1">
        <property type="nucleotide sequence ID" value="XM_027415158.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G000"/>
    <dbReference type="GeneID" id="100762281"/>
    <dbReference type="KEGG" id="cge:100762281"/>
    <dbReference type="CTD" id="57562"/>
    <dbReference type="OrthoDB" id="9900339at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028257">
        <property type="entry name" value="CEP126"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31191">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31191:SF4">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 126 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15352">
        <property type="entry name" value="K1377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027270959.1"/>
        </source>
    </evidence>
    <sequence length="1100" mass="123364" checksum="A6345459A836F228" modified="2023-06-28" version="1">MLAGRPGAQSAGAGRSDSPGAKDGGRRPRPCAYLRDMKIHLEKNLEEERKILLQQQKICRNRARKYFIESSRRRKAFEEKRREQEEREHQMRERILQQRKQKLEEVTEKFQRCHVPLSHRRRAVFHSPVPPLEEALKQIQESNLKSELNIPHSHRPATSWQAIDSALPTPLSKNDHKHQKYLVRRINCDKEMKENNIANVATNKNVFQLKLEETQKLLENQHLSSLQKFCDEVNQITNSETLSSVDSLEAGEREEIYITLMTPSTSAQPNSVPLKSASLQSAHLNYYDEDRLSLSKTQHINNWLTNIDAQNTQPVASFSDILSKSSVLPSWECLSNKEQNPPTLSRTVERATKTANDSVLFVCSPSVVALDKKRENTSEGNTVRTSESTCGTPQREWLPSAKSPAFKVSGAWTTPEPLTQEAPSFSIQERLSELTQENRTASIPASFVPLLSPNSQSSGPSPENNTHIKEINPVQCSDKLDELKDVKYEKISYLNCNKEKLSLFSGNFQATCAPQNSNSKDRKQKASGPSAPLCNITPDCDLPDHSMKHMVHEQNGVRLLKSILKKESRYDHDYLKALVINQGFRFRHQKAEAIRDSIELTKQKGKGTGTPKTTKKLRWLDESNYTENCMDDSHPVRNRAGMALQWLQHYHTRSVQVPTCNPTSIPDCTAHSAGGKKAKADGVSENVTDSGGYEMDSVPLNFSTPAGCSFAKQAWSACRREDNKAPMHAGDAKTQKSKLPRSAKGTRRAGSTKVQTGLLYMNRKTTISQPLSSSKANTLAQAQGKLIIPNPLPKPPTNIKNGKNMQMSPCHLATPEQSQNIMTQNYLSSCMLPTEYRLNQWTQESHPPFPDSCSDLLAVTPALPTPHSAECQTSAKANYSNSTHTGFQQDGTVYCTQGSPVCEESNQSLTHRSTEEESVLSWKRRNNGCHNDRATDSAVTRRKQVIGNKWRNLLEQKRKISGSVGMKHTEQMIHFGQSVPLSASEPVQATRGPKTEEVSGSTSERLVPEDEILTAINSKPLQKPNLSLSKTHPANTCAVSAEEQKVLKSLRHLNQRLYYVQEAIYKNPSIKNTLQLIPLLNSQPRTRFSPDTGSRVQKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G5Q8</accession>
    <name>A0A9J7G5Q8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100752325</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276951.1">
        <property type="nucleotide sequence ID" value="XM_027421150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G5Q8"/>
    <dbReference type="GeneID" id="100752325"/>
    <dbReference type="KEGG" id="cge:100752325"/>
    <dbReference type="OrthoDB" id="9575991at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15945">
        <property type="entry name" value="7tmA_OR5C1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027276951.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34640" checksum="C8810CB4BB8CCBF0" modified="2023-06-28" version="1">MEKGNCSSLPEFLLLGITNNPEVKVLLFTMFLIVYLTNLLTNLGMIILIKMDPQLHTPMYFFLSQLSFSDLCYSTAIGPKMLVDLLSKNTSIPFLGCAAQFFTFCIFIDAECVLLAVMAFDRYKAISNPLLYSVDMSSSVCFQLLTGVYAVALADALVHTTLTFHLCFCGSNKINHFFCDIPPVLVLSCSDTQVNVLVIFTVFGFIELSTISGVLVSYCYIISSVLKISSTSGRLKAFSTCTSHLTAVAIFQGTMLFMYFRPSSSYSLDQDKVTSLFYTLVIPMLNPLIYSLRNKDVKEALQRVKSKMCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G9H9</accession>
    <name>A0A9J7G9H9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Propionate--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.1</ecNumber>
            <ecNumber evidence="3">6.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Acss2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:23177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20373"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:20374"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="4"/>
    <dbReference type="EC" id="6.2.1.17" evidence="3"/>
    <dbReference type="RefSeq" id="XP_016830467.1">
        <property type="nucleotide sequence ID" value="XM_016974978.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277177.1">
        <property type="nucleotide sequence ID" value="XM_027421376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G9H9"/>
    <dbReference type="GeneID" id="100752902"/>
    <dbReference type="KEGG" id="cge:100752902"/>
    <dbReference type="CTD" id="55902"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF126">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="15">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="13">
        <location>
            <begin position="115"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="13">
        <location>
            <begin position="348"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="14">
        <location>
            <begin position="608"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027277177.1"/>
        </source>
    </evidence>
    <sequence length="726" mass="81613" checksum="811BCEF67EEDD96C" modified="2023-06-28" version="1">MGLPEEQRKSDSGSRAREETGSEGRVRGWSPPPEVRRSAHVSSLQRYRELHRHSVEEPGEFWGNIAKEFYWKTPCPGPFLQYNFDVTKGKIFTEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTKITYRELLVQVCQFSNVLRKQGIQKGDRVAIYMPMILELVVAMLACARLGALHSIVFAGFSAESLCERILDSSCSLLITTDAFYRGEKLVNLKELADESLEKCREKGFPVRCCIVVKHVGRAELGMNDSPSQSPPVKRQCPDVQISWNEGVDLWWHELMQEAGDEFEPEWCDAEDPLFILYTSGSTGKPKLCAGSICWSVEMDTKPQPEDPFSPQGVVHTIGGYMLYVATTFKYVFDFHPEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDESRLWSIVDKYKVTKFYTAPTAIRMLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGSQHCPIVDTFWQTETGGHMLTPLPGATPMKPGSASFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTIYGNHTRFETTYFKKFPGYYVTGDGCRRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSSTLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDTSTVADPSVINHLFSHRCLTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GAS9</accession>
    <name>A0A9J7GAS9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Rars1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity. Interacts (via N-terminus) with LARS2 (via C-terminus). Monomer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18. Interacts with QARS1. Part of a complex composed of RARS1, QARS1 and AIMP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027281025.1">
        <property type="nucleotide sequence ID" value="XM_027425224.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GAS9"/>
    <dbReference type="SMR" id="A0A9J7GAS9"/>
    <dbReference type="GeneID" id="100767723"/>
    <dbReference type="KEGG" id="cge:100767723"/>
    <dbReference type="CTD" id="5917"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000016">
        <property type="entry name" value="Arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000002">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000084">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="18">
        <location>
            <begin position="79"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="17">
        <location>
            <begin position="535"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027281025.1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75602" checksum="12EB1C85655EB8F4" modified="2023-06-28" version="1">MDGLVAQCSARLLQQEKEIKSLTAEIDRLKNCGHLEDSPSLDQLREENLKLKYRLNILQRSLQAEKRRRPTKNMININSRLQDVFGCAIKAAYPDLDNPPLVVTPSQQPKFGDYQCNSAMGISQMLKAKEQKVNPRGIAENITKHLPNNEYIDRVEIAGPGFINVHLRKDFVSEQLTNLLVNGIQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESMSRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDQFPDYLTVSPPIGDLQAFYKESKKRFDTEEEFKKRAYQCVVSLQSKDPDFIKAWNLICDVSRAEFNKIYDALDITLIERGESFYQDRMKDIVKEFEDKGYVQVDDGRKIVFVPGCSIPLTIVKSDGGFTYDTSDLAAIKQRLFEEKANKIIYVVDNGQAVHFQTIFAAAQMIGWYDPKVTQVTHVGFGVVLGEDKKKFKTRSGETVRLVDLLGEGLKRSMDKLKEKERDKVLTEEELTAAQTSIAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANVDEEMLQKAARETKIVLDHEKEWKLGRCILRFPEILQKMLDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQTGKVLKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GCK9</accession>
    <name>A0A9J7GCK9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100766727</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003509221.1">
        <property type="nucleotide sequence ID" value="XM_003509173.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281971.1">
        <property type="nucleotide sequence ID" value="XM_027426170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GCK9"/>
    <dbReference type="GeneID" id="100766727"/>
    <dbReference type="KEGG" id="cge:100766727"/>
    <dbReference type="OrthoDB" id="9975554at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15918">
        <property type="entry name" value="7tmA_OR1_7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027281971.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35634" checksum="C712CA69D5B2EDC5" modified="2023-06-28" version="1">MQGNTKRNQTVISQFLLLGLPIPTEHQNLFYSLFLAMYLITVLGNLLIIILIQLDSHLHTPMYSLLSNLSFSDLCFSSVTMPKLLQNMQSQVPSIPYAGCLAQMYFFLFFADLESFLLVAMAYDRYVAICFPLHYTSIMSPKLCVGLVVFSWVLTTFHAMLHTLLMARLSFCEDNVIPHFFCDMSALLKLSCSDTHVNELVIFITGGLILVIPFVLIVVSYARIVSSILKVPSARGIRKAFSTCGSHLSVVSLFYGTVIGLYLCPSANNSTLKETVMGMMYTVVTPMLNPFIYSLRNRDMKGALFRVLCKKKILFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GGY2</accession>
    <name>A0A9J7GGY2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Cation channel sperm-associated protein subunit gamma isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9 10" type="primary">Catsperg</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7 8 9">17A/GY</strain>
            <tissue evidence="7 8 9">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027286352.1">
        <property type="nucleotide sequence ID" value="XM_027430551.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286358.1">
        <property type="nucleotide sequence ID" value="XM_027430557.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305316.1">
        <property type="nucleotide sequence ID" value="XM_035449425.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305321.1">
        <property type="nucleotide sequence ID" value="XM_035449430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GGY2"/>
    <dbReference type="GeneID" id="100764558"/>
    <dbReference type="KEGG" id="cge:100764558"/>
    <dbReference type="CTD" id="57828"/>
    <dbReference type="OrthoDB" id="9949093at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097228">
        <property type="term" value="C:sperm principal piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028246">
        <property type="entry name" value="CATSPERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053871">
        <property type="entry name" value="CATSPERG_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053873">
        <property type="entry name" value="CATSPERG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053874">
        <property type="entry name" value="CATSPERG_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053872">
        <property type="entry name" value="CATSPERG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14327:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14327">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15064">
        <property type="entry name" value="CATSPERG_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22846">
        <property type="entry name" value="CATSPERG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22851">
        <property type="entry name" value="CATSPERG_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22840">
        <property type="entry name" value="CATSPERG_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERG N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERG beta-propeller" evidence="2">
        <location>
            <begin position="208"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERG Ig-like" evidence="5">
        <location>
            <begin position="754"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERG C-terminal" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027286352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027286358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035305316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035305321.1"/>
        </source>
    </evidence>
    <sequence length="1212" mass="139294" checksum="3BB3B6BA49B2DCE2" modified="2023-06-28" version="1">MVCWPAMSPVSPVWSRRPSVWACWGLLLVLLLSWKSWAVYHLQQCRWLVVLNKFEKVGSLPSKDRFLEQEPTDTVAEVFEKLVDSPVDPREKYMGFPYYLKVNYSCMGKDDEELSRKGHLMGMRPVVLISYKYPVNFYHWKIENLQIQMEAAPLRSSGFCIAEIVCALNWYVPMPIKNGSVVMSVDIRSNGLGPYIPPTRFYMNMNGFLKRDESGKPIFTMGYETFIMKTAHFKRSKSRPLWYTINHSPVFILGGIEDEKTILLSDTSFQDYSLVELSIDSCWVGSYYCPMLEFSATIHDAISTESTLFIRQNQLVYYFTGRYSSLFDNSRSSSSWVRVLASECIKRLCPVFIHGNGSEYILALTTGKHEGYIHIGTITDGLVSFRMVPEKWSICDKFIGTNCSINWATYITDEKILLLLVQVLSWDSALVYNLVSFNLETQNLEVLYVLPLFIPEAQGLDFLVLDGTEPYTTTSMVPKGLFFNTFNNMLYIWGNFILQSYNRIHFIYLADFPKESTIKYMVNSYQGDMAFVTEKDEIWYFLEGGYDVYQIIPSKGWSIYFNLQKMHQSSLFAEQEFLVSVFYEDGQLYQLIYLLESGNERLVKRVLPVAQLLLYNQNNPVTLQKHGSYRMPFFTNFCPFKVMRLRDLPKKQHFARQELYHAPPPLVSESLGFHNNKTLAVYQGLVYYLLWLHSKYDKPYADPVHDPTWRWWEQKTQYKDYYFYLSSNWLAAEGVYIDMSSYQKLYNISNDYGLPETVFLDKGNAFSFTIFLSSDDDTFKLNSNPVTGYQVEKKLAVAVAVADPDCLKASVKQEVLLNRKAVLYRITIKDRKVCYDQGLSGHNLKKTSMMVKVLGSSGKCFQTSYSGTSMQGHLMVPVLIGCPPGKRLAFDVTYTILHSRELNKHYFDCGRTNPEMPCFLFRDCVFHPFSRVHCPPVLAILSPLPSSLCVQPSAPTPSSPPLPSCSSLDKANFFLPSSPSQPTVFQPFFLIQDMVTGDSGSFLGSYLLKVVGGGHTIDTIRDYTEEEIYHYNSPLDKTNSLIWKTKVERTTLDKKFYIMSYQSPGIEWLCLENSPCHDITPQNIFAPEFFLKLLVSNRGVDTSTYCDYQLIFVLHMHGLPLSGKRSLFIVIVSISLLVGLVVFYILFLLLWPHIVRAWISLRWKINNIMASESYYTYATSNPAFSFQSHSGSEQSYKEGSKEETIVKKEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GN91</accession>
    <name>A0A9J7GN91_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MLV-related proviral Env polyprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC113833976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035295734.1">
        <property type="nucleotide sequence ID" value="XM_035439843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GN91"/>
    <dbReference type="GeneID" id="113833976"/>
    <dbReference type="KEGG" id="cge:113833976"/>
    <dbReference type="OrthoDB" id="9634693at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09851">
        <property type="entry name" value="HTLV-1-like_HR1-HR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.310.10">
        <property type="entry name" value="ENV polyprotein, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008981">
        <property type="entry name" value="FMuLV_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF72">
        <property type="entry name" value="BC035947 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49830">
        <property type="entry name" value="ENV polyprotein, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035295734.1"/>
        </source>
    </evidence>
    <sequence length="656" mass="72458" checksum="2A93F76CF56B59AF" modified="2023-06-28" version="1">MDRTPHSKSFKDKTLSYTLLLIGCLFTPHVATNPHRVYNITWKIANLGTGEIANLSTYIGTLHDGFPPLYVDLCDLVGSDWDPSDQEPFPGYGCHHPGGRIGTRSKDFYVCPGHKPTHGCGGPQEGYCARWGCETTGEAYWKPSSSWDFITLKRREIPGYAGKGPWRCGQRACGPCYDSAGGGGFQGATPGGKCNPLILRFTDAGKRTTWDSPKVWGLRLHRAGKDPVTLFSLYRQITPLSQQSVGPNTVIADQRAPTQFQVPEPPTIPKATPGAVTFSPTPDALNIEITRDPPGTGDRLLQLIQGVYQALNFSDPNKTQECWLCLVSRPPYYEGVAILGNYSNQTSAPTSCGAAMQHKLTISEVSGKGLCIGRIPPSHQELCNQVEPLSQDSRYLVAPYGTYWACSTGLTPCVSTTVLNTTIDFCILIELWPKVTYHQPEYVYSVLEKSTRYKREPISFTVALLLGGITVGGIAASIGTGTIALQGINHFKLLQQAMHTDIQVLEESVSALEKSLTSLSEVVLQNRRGLDLLFLQEGGLCAALKEECCFYADHTGIVRDSMAKLRERLKQRQQLFESQQGWFEGWFAKSPWLTTLISTLMGPLVILFLILIFGPCILNKLTQFIRERLSVVQALVLTQQYHQLKQIDPEYPETSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GN94</accession>
    <name>A0A9J7GN94_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100771771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294994.1">
        <property type="nucleotide sequence ID" value="XM_035439103.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310938.1">
        <property type="nucleotide sequence ID" value="XM_035455047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771771"/>
    <dbReference type="KEGG" id="cge:100771771"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035294994.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13848" checksum="CBA4E4939E454EFE" modified="2023-06-28" version="1">MSKQGHVVSSGVKFCFSLGLPVGAVINCTDSAGTKYLHIISLKEIKGQLERLPAAVVGNMVIATLKRSKSAVRKEXVVIKQQKFFXFEDDAGIIVNNKGVTKGPVITGPVPKKCSDLWPRTAFDAGRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GNH9</accession>
    <name>A0A9J7GNH9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lymphocyte antigen 6H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100758308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with CHRNA4 and CHRNA7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035294694.1">
        <property type="nucleotide sequence ID" value="XM_035438803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GNH9"/>
    <dbReference type="GeneID" id="100758308"/>
    <dbReference type="KEGG" id="cge:100758308"/>
    <dbReference type="OrthoDB" id="9620902at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033130">
        <property type="term" value="F:acetylcholine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030550">
        <property type="term" value="F:acetylcholine receptor inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0095500">
        <property type="term" value="P:acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23549">
        <property type="entry name" value="TFP_LU_ECD_Ly6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000011">
        <property type="entry name" value="lymphocyte antigen 6H isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051445">
        <property type="entry name" value="LY6H/LY6L_nAChR_modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32217">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32217:SF5">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UPAR/Ly6" evidence="12">
        <location>
            <begin position="174"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035294694.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="30381" checksum="9CA4C74C02CDD2D0" modified="2023-06-28" version="1">MDKKELWLTTQSPGVDLANAPYSKIRVVTFWPRAPPAPRVSPPRAAPAPAPPRPSRGVRVCGCVPRKTKLRPGSGPHSTPRFAVSAEARARGPGEGTRRGVPGPPAQGWGRGRGRGRGTYPPPSPQVRPAPQRTPACSPRASLRPSQSMLPAAMKSLGLALLALLLCLSPAHGLWCQDCTLANSSHCAPKQCQPTDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKRHFFSDYLMGFINSGILKVDVDCCEKDLCNGASATGRSPWALAGGLLLSLGPALLWAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GP53</accession>
    <name>A0A9J7GP53_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 431-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC118237701</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289652.1">
        <property type="nucleotide sequence ID" value="XM_027433851.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GP53"/>
    <dbReference type="GeneID" id="118237701"/>
    <dbReference type="KEGG" id="cge:118237701"/>
    <dbReference type="OrthoDB" id="3156061at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000555">
        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF96">
        <property type="entry name" value="GENE, 32687-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027289652.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50995" checksum="5A03CE6A8AADE862" modified="2023-06-28" version="1">MLETYKNLNDIGYIWEDHTIEEHGASSKRHERHETNQIGEKSSLYTEYVKAFAYNSNLQRHKQTCTGEKPYECIHCCKVLATHSNFQKHKRKYTGEKIYESNQYGKAFAKHIQIEGHKRTHTGQKPYECNQCGKAFPQHSHLQRHKRTHTGEKPYECTQCGKGFADPSSLRVHKRTHTGEKPYECTQCGKGFADPSSLRVHKRTHTGEKPYECNQCGKAFAQHIHLKRHKITHTGEKPYECNQCGKAFAQHIHLQRHKITHTREKPYECNQCGKAFSHQSHLQRHKRTHTGEKPYECNQCGKAFAQHSHLQKHKRTRTGEKPYPCTQCGKAFMCHSHLQSHKRIHTGEKPYECNQCGKGFADASSLLVHKRTHTGEKPYECTQCGKAFAQNSHLQRHKRRHTGEKPYECNYCGKAFADPSALCVHKRTHSGEKPYECTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQB5</accession>
    <name>A0A9J7GQB5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100765721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_035439803.1"/>
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        <property type="nucleotide sequence ID" value="XM_035456383.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100765721"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
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        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
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        <property type="entry name" value="Ribosomal_uS14_sf"/>
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        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
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        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
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    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035295694.1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6611" checksum="8E0AC45CACEF7531" modified="2023-06-28" version="1">MGHQQLYWSHPRGSSLVRKFGQGPGSCHICSNCHGLIRKYGLNMCRQYSKDIGFIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQS9</accession>
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        <submittedName>
            <fullName evidence="6">Microtubule-associated protein 1B isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Map1b</name>
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    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035296410.1">
        <property type="nucleotide sequence ID" value="XM_035440519.1"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:neuronal cell body"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:actin binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of microtubule depolymerization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MAP1"/>
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        <property type="entry name" value="MAP1A/B/S-like_MBL"/>
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        <property type="entry name" value="MAP1B/S_N"/>
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    <dbReference type="InterPro" id="IPR000102">
        <property type="entry name" value="MAP1B_neuraxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843:SF5">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00414">
        <property type="entry name" value="MAP1B_neuraxin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23415">
        <property type="entry name" value="MAPB1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25281">
        <property type="entry name" value="MBL_MAP1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00230">
        <property type="entry name" value="MAP1B_NEURAXIN"/>
        <property type="match status" value="4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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    <feature type="domain" description="Microtubule-associated protein 1B/S N-terminal" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Microtubule-associated protein 1A/B/S-like MBL-like" evidence="4">
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            <begin position="277"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="2499" mass="274399" checksum="F12FB1B76DCF00B4" modified="2023-06-28" version="1">MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPVSRATSEVEIPLLSQKQASSFHLEKLKVSSLCVFVPSGQKILHHRSDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEMEGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQWTGTNKDKAELILPNGQEVDIPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPTVKQVKLKQRADSRESLKPATKPLPSKSVRKESKEEAPEVTKPSQVEKTPKVESKEKVTVKKDKPIKTETKPSVTEKEVPSKEEQSPVKAEVAEKQATESKPKVTKEKVVKKEIKAKPEEKKEEKEKPKREVAKKEDKTPLKKDEKPKKEEVKKEVKKEIKKEEKKELKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKISKDIKKSTPVSETKKPAALKPKVAKKEEATKKEPAAASKLKDKGKVKVIKKEGKTTEAAATAVGTAATTAAAVAAAGIVATGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDIKPQLELIEDEEKLKETESVEAYVIQKETEVLKGSAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNVSGSASKHSPTEDDESAKAEADVHIKEKRESVTSGDDRAEEDMDEALEKEEAEQSEEEGEEEDKAEDAREEDYEPEKLEGEDYVMAVVDKAAEAGVAEEQYGFLSTPTKQPGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPIVASFNGLSEGSKTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEEKEVKASAALDIKDVSDERLSPTKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEADVTSVSPGMTQAVVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKASHLPTEATEKPQAVPVSFEFSEEAKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYEDFLSADGKALGRGIESPFEGKNEKQGESPVSEVTSTGLYQEEQEGKSTGFIPIREDFGPEKKTNEVEIMSSQSALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEHSLAMDFSRQSPDHPTVGASMLHITENGPTEVDYSPSDIQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDMSLYASLTSEKAQSLEGEKLSPKSDISPLTPRESSPLYSPGFSDSTSATTENAAGRQTSSPPMDAASAEPYGFRASMLFDTMQHHLALNRDLTTSSVEKDSGGKTPGDFNYAYEKPEKTTRSPDEEDYDYESYEKTSRAPDTDGYYYEKTERTIKSPCDSGYSYETIEKTIKPQEDGGYACEITEKTTRTPEEGGYSYEISEKTTRTPEVGGYTYEKTERSRRLLDDISNGYDDSEDGGHTLADCSYSYETTEKISSFPESESYSYEMSTKTTRSPDTATYCYETMEKITKTPQASTYSYETSDRCYTPEKRSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEESTEDSEKPLAESGGAPPPSGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKADGKSKPLAASPKPGALKESSDKVSRVASPKKKESVEKATKTTTTPEIKATRGDEKDKETKNAANASASKSAKTATAGPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDESFPACKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GVV2</accession>
    <name>A0A9J7GVV2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibroblast growth factor</fullName>
            <shortName evidence="6">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Fgf8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297216.1">
        <property type="nucleotide sequence ID" value="XM_035441325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GVV2"/>
    <dbReference type="GeneID" id="100750999"/>
    <dbReference type="KEGG" id="cge:100750999"/>
    <dbReference type="CTD" id="2253"/>
    <dbReference type="OrthoDB" id="5988014at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23322">
        <property type="entry name" value="beta-trefoil_FGF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000007">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0339">Growth factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035297216.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49249" checksum="0458B687C90A702E" modified="2023-06-28" version="1">MHPLPAAPPRAAPPPPGRRPGPSAQPGGAGFGRPPRTPPSRPVRRPPPLPFTSLPPPHPPRRPVTLPPAPAPEQPAATGSGSGAERISARGEHDIPRDPPSRVGIVAGLPHPDLPRPPPLRLVPRPPAASRVPRSPRVPVGRRPPRPLCSPRASLLPAFVSHRLLHLLLLCLQAQVRSAAQRRGPGAGDPADTVGQGHEDRPFGQRSRAGKNLTNPAPNYPEEGSKEQRDSVLPKVTQREGPGGGPALGREPASLLRAGREPQGVSQQHVREQSLVTDQLSRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKKGKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GWC2</accession>
    <name>A0A9J7GWC2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich single-pass membrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Lsmem2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035299830.1">
        <property type="nucleotide sequence ID" value="XM_035443939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310429.1">
        <property type="nucleotide sequence ID" value="XM_035454538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GWC2"/>
    <dbReference type="GeneID" id="100753916"/>
    <dbReference type="KEGG" id="cge:100753916"/>
    <dbReference type="CTD" id="132228"/>
    <dbReference type="OrthoDB" id="9447266at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031674">
        <property type="entry name" value="DUF4714"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37333">
        <property type="entry name" value="LEUCINE-RICH SINGLE-PASS MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37333:SF1">
        <property type="entry name" value="LEUCINE-RICH SINGLE-PASS MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15833">
        <property type="entry name" value="DUF4714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035299830.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15126" checksum="A472155936847E7A" modified="2023-06-28" version="1">MQNQRSRGTLAPNHVQEVHLHRVESISELHSGGSLQPYLAEEAQTWEELLGVLPPSLCTQAGCSPMCGRGGFLLLLALLVFTCLALAILAVYLSVLQSESLRVLAHTLRTQEETLLKLRLASLSQLRRLNSTEARAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZY3</accession>
    <name>A0A9J7GZY3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">SPARC-related modular calcium-binding protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Smoc1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
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            <strain evidence="16">17A/GY</strain>
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            <strain evidence="16">17A/GY</strain>
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        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
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            <strain evidence="8">17A/GY</strain>
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    </dbReference>
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        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="304"/>
            <end position="313"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035304008.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39152" checksum="77FDC6868C98DA56" modified="2023-06-28" version="1">MSENKGENMKVQTLTKYIKFLTRKRGGVPDEDYLKRLYQEYSPAQWDLDGRTRSCQDPDVRAHGSPNPAPRARARRWRSSGLNRRLRLVGLALWPILGPSAPSPPAPSLAPPSAALALPAGPAEAVCALCQRAPXEPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRAVEPGRPPLSRRLLALEEAAAAPTRDGPASEAALQLLCRADGDPLCSACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKDEGPSEDDEQADPAERFRSLLQAVSELEKKHRNLGLSMLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H9X7</accession>
    <name>A0A9J7H9X7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Melanoma-derived growth regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC103159367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIA/OTOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305382.1">
        <property type="nucleotide sequence ID" value="XM_035449491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H9X7"/>
    <dbReference type="GeneID" id="103159367"/>
    <dbReference type="KEGG" id="cge:103159367"/>
    <dbReference type="OrthoDB" id="6627676at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000175">
        <property type="entry name" value="Melanoma-derived growth regulatory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043369">
        <property type="entry name" value="MIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47312">
        <property type="entry name" value="MELANOMA-DERIVED GROWTH REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47312:SF1">
        <property type="entry name" value="MELANOMA-DERIVED GROWTH REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039924452" evidence="8">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="42"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035305382.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16282" checksum="B42E0F2640E2276D" modified="2023-06-28" version="1">MMVWLPVLLGVILSVFPGPIEAERDMPKLADWKLCADEECSHPISMAVALQDYMAPDCRFLNIYRGQVVYVFSKLKGRGRLFWGGSVQGDYYGDLAARLGYFPSSIVREDLILKPAKIDMKTDVSALWWRWECMCNQALLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HDI9</accession>
    <name>A0A9J7HDI9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 431-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC113837944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309719.1">
        <property type="nucleotide sequence ID" value="XM_035453828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HDI9"/>
    <dbReference type="GeneID" id="113837944"/>
    <dbReference type="KEGG" id="cge:113837944"/>
    <dbReference type="OrthoDB" id="9827751at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="12">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035309719.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="67811" checksum="7360711E8D4E3BCD" modified="2023-06-28" version="1">MASIMISIAYMYVIFQNAITYDDVHIDFTSEEWALLDISQKKLYKDVMLETYKNLTDVGYSWEDHTIEERCSSSERQERHERRQTGEQFSVYTKCVKPFAYNSHLQRHKRAHTGDNPYQCNQCGKAFAHHSVHHVHKRNHNGEKPYESNQCVKSFAKNNTLQIHERSHIEEKHYECNQCDKTFSRHSLLQRHKRTHTGEKPYECNQCGKAFSRHSHLQRHKRTHTGEKPYECNQCGKAFSQHSILQRHKITHTGEKPYECDQCGKGFAYPSALHLHKITHTGEKPYECNQCGKAFSRHSNLQMHKRTHIGEKPYECNQCGKAFSRHNHLQMHKRTHTGEKPYACNQCGKAFAKHSTLQMHKRTHTGEKPYECIQCGKAFSRHSHLQIHNRTHTGEKPYECNQCGKPFSRHSHLQSHKRTHTGEKPYACDQCCKTFSRHSHLQMHKRTHTGEKPYQCNQCGKAFARHSHLRMHIKTHSGEKPYTGEKPYEYNHCGKAFADPSALRLHKRTHSREETYKCSQCGKAFIQQIQLQEQKTHTGEKPYECNQGCKVFACQSFFKIKGAQTGVKPFYGNQCACIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HED1</accession>
    <name>A0A9J7HED1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100763196</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Interacts with RB. Interacts with FAM168B/MANI. Interacts with MCPH1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035308832.1">
        <property type="nucleotide sequence ID" value="XM_035452941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763196"/>
    <dbReference type="KEGG" id="cge:100763196"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000085">
        <property type="entry name" value="Cell division cycle 27 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000051">
        <property type="entry name" value="Cell division cycle protein 27 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="18" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="669"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="737"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="349"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="782"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035308832.1"/>
        </source>
    </evidence>
    <sequence length="824" mass="91961" checksum="E9F956ABC1946BFD" modified="2023-06-28" version="1">MIVLQEPVQAAIQQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYHSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDHTFKLTSIQNFSSCLSNTCTTLVSNHNLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSMTYIDSAVISPDNVPLGXGASILSKQVQNKTKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDMPSTRAPTKKFVARMGQTGTKSVFSQSGNSQEVTPILVTQTQSSGPQTSTTPQVLSPTITSPPKALPRRSSRLFTSDSSTAKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFKLQKAAAGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTDRVLCQIGRAYFELSEYMHAERIFSEVRRIDDYRVEGMEIYSTTLGHLQKDVALSVLPKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYVYVYTLLGHEFVLTEELDRALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVINPKNPLCKFHRASVLFANEKYKSALQKLEELKQIVPKESLVYFLTGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HEP9</accession>
    <name>A0A9J7HEP9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease inhibitor Kazal-type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC113830786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035308933.1">
        <property type="nucleotide sequence ID" value="XM_035453042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HEP9"/>
    <dbReference type="GeneID" id="113830786"/>
    <dbReference type="KEGG" id="cge:113830786"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000031">
        <property type="entry name" value="Serine protease inhibitor Kazal-type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042167">
        <property type="entry name" value="SPINK2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47608:SF1">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47608">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 2, SPINK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035308933.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11316" checksum="C53B3EC2DB3E2BA6" modified="2023-06-28" version="1">MGEEDQLRDDSVGLLGMCCGCECVPLLAVLPVSSNYLDLTESHIVQPSEFRTPNCGHYDYPACPRNLNPVCGSDMNTYGNECTLCMKIREDGNPIKIIKDSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HFX1</accession>
    <name>A0A9J7HFX1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Poly(A) polymerase</fullName>
            <ecNumber evidence="14">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC100774938</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="14"/>
    <dbReference type="RefSeq" id="XP_035309648.1">
        <property type="nucleotide sequence ID" value="XM_035453757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774938"/>
    <dbReference type="KEGG" id="cge:100774938"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF9">
        <property type="entry name" value="POLY(A) POLYMERASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="20">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="19">
        <location>
            <begin position="220"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="18">
        <location>
            <begin position="367"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="524"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035309648.1"/>
        </source>
    </evidence>
    <sequence length="740" mass="82615" checksum="6A3E99E987BA2BE2" modified="2023-06-28" version="1">MMPFPVIMQGSQQRQTPKRHYGITSPIILAAPKETECLLTKKLIETLKPFGVFEEEEELQHRILILGKLNNLVKEWIXEISESKNLPQSVIENVGGKIFTFGSYGLGVHTKGADIDALCVAPRHVDRSDFFTSSYDKLKLQEEVKDLRAVEDAFVPVIKLCFDGIEIDILFARLALQTILEDLDLRDDSLLKNLDIRCIRSLNVCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFFGGVSXAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPMWDPRVNPSDRKHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAHTEKQRLECVDLVESKICILVGSLEKNEFIKLAHVNPQSFPAPKDNPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYSQAINSKMFELDMKITTMHVKRKQLHQLLPSHVLQKRKKHSTEGVKLTALNDSTLDLSMDSDNSMSVPSPTSAMKTSPLNSSGISQGRNSPAPAVTKASVTSIQASEFSVPQANSSGSSGGKSSESIPQNATQPAISPPPKPTVSRVVSSTRLVNPSPRTSGNAATKVPNPIAGVKRTSSSYKEESPKQTKTDEDKTSEDAKCLDLSANDKKETKDQVDMETSAIQSETLPYSASLLASQKTSSTDLSDIPALPANPIPLIKNSIKLRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J6N6</accession>
    <name>A0A9J7J6N6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100761906</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Possible taste receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007653014.1">
        <property type="nucleotide sequence ID" value="XM_007654824.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251814.1">
        <property type="nucleotide sequence ID" value="XM_027396013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J6N6"/>
    <dbReference type="GeneID" id="100761906"/>
    <dbReference type="KEGG" id="cge:100761906"/>
    <dbReference type="OrthoDB" id="9035478at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15229">
        <property type="entry name" value="7tmA_OR8S1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000015">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027251814.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="33849" checksum="7C22CD8D9A375B1D" modified="2023-06-28" version="1">MGNLSVVSEFILLGLPADAQIQATLFVIFLVIYVLTLTGNSVILLVIIADAHLRSPMYFFLGHLSFVDLSYSTVSVPKMLENLMAKSKTIPVKGCLAQAFFVFAIGGTEALLLAVMAYDRYAAICHPLLYGQMMSNGFCEGLVFGSWGLAILNSLINTLLAVNLDFCDYGTIHNYNCEIPSLFPLSCSDVSTNATVLLWSFVIHASGTFLLVLSSYGCIFSTILNMRSTTGRSKAFSTCSSHLTIVILYFGSACLRYTMPTSGSPMEIIFSLQYSVITPMLNPLIYSLKNKEVTTAIRKMLGKCCQHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J7E4</accession>
    <name>A0A9J7J7E4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA N(3)-cytidine methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Mettl6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50956"/>
            <dbReference type="Rhea" id="RHEA-COMP:12849"/>
            <dbReference type="Rhea" id="RHEA-COMP:12851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74894"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50957"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with SARS1/SerRS; interaction is mediated via tRNA(Ser) and is required for N(3)-methylcytidine methylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_027245323.1">
        <property type="nucleotide sequence ID" value="XM_027389522.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281950.1">
        <property type="nucleotide sequence ID" value="XM_027426149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766645"/>
    <dbReference type="KEGG" id="cge:100766645"/>
    <dbReference type="CTD" id="131965"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000279">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="14">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027245323.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34722" checksum="DD52AC07124DDAE3" modified="2023-06-28" version="1">MVKDQRIFSRVEATAMASFQRKGLQARMLSSEEEEKLQRDQALVSDFKQQKLEKEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSCREYEDQKLTLLEAGCGVGNCLFPLLEEDLNIFAYACDFSPRAVDYVKQNPLYNTERCKVFQCDLTKDDLLDHIPPESVDAVTLIFVLSAIHPEKMHLVLLNVYKVLKPGRSVLFRDYGLHDHAMLRFKAGSKLGKNFYVRQDGTRSYFFTDEFLAKLFVDAGYEEVANEYVFRETVNKKEGLCVPRVFLQSKFRKPPKDXDPTIDSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J800</accession>
    <name>A0A9J7J800_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="17">PARP</shortName>
            <ecNumber evidence="17">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Parp4</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:58224"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15089"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142540"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="17"/>
    <dbReference type="RefSeq" id="XP_027246310.1">
        <property type="nucleotide sequence ID" value="XM_027390509.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100765231"/>
    <dbReference type="KEGG" id="cge:100765231"/>
    <dbReference type="CTD" id="143"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17726">
        <property type="entry name" value="BRCT_PARP4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000065">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000083">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000013">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031273">
        <property type="entry name" value="PARP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058904">
        <property type="entry name" value="PARP4_MVP-ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058905">
        <property type="entry name" value="WGR-like_PARP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46530">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46530:SF1">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26156">
        <property type="entry name" value="PARP4_MVP-ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26166">
        <property type="entry name" value="WGR-like_PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="22">
        <location>
            <begin position="239"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="21">
        <location>
            <begin position="366"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="23">
        <location>
            <begin position="604"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="20">
        <location>
            <begin position="873"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1374"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1558"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1376"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1566"/>
            <end position="1582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027246310.1"/>
        </source>
    </evidence>
    <sequence length="1781" mass="197028" checksum="67EF3977393B719E" modified="2023-06-28" version="1">MTLGIFANCIFCLKIKYLPRQQKKKLQTDIKNNGGKFSFLLNPQCTHVILDNADALSQYQLNSIQKNDVQIASPDFIWDSVNQRRLMNVTNYDPKSLALMPPPGEKGCAEVETEDVSLDNTPENENTEVTQVSAENVEIPHFLQDFEVVKYNVLEKVGADGDQEAAVVELQCSQDPGDCPFVISAHFLLADHLQTRRESIGKQTSESASEYYEHYIEDLKRQGFLLQEHFTAEATQLASEKLQALLLEEVISSGTLSQEVSDLVEMVWAEALGHLEQTLLKPVNSISLNDVSKAEGVLLLVKSALKNGETQEQLQKAMADFYRLIPHKHPASEDVNLRLLAQKEDLCQLVRDMVNVCETNLSKPNPPSLAKYRALRCKIEHVEKNTEEFSRVRKEVLQSNHSANPVDVLQIFRVGRVNEASEFLSKLGNVQSLFHGSPVRNILGILSRGLLLPKVVEDRGVQRTDAGSLGSGIYFSDSLSTSIKYSHAGETDGARLLVICDVALGKCMDLLKKDFSLTEAPPGYDSVHGVSKTASVPTDFEDDEFVVYKTNQVKMKYIVKFLIPGDQIKDFHPHENTELEEHRAAPSNVSKPEDFQLPDIKPLASIKAGLQDASANSVPLDSVHIKGRIIDFVAQVIVFQTYTNQSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIVGEIKEKEEAKQEYREAISQGHGAYLMDQDTPDVFTVSVGNLPPRAKVLIKITYITELSIQSPVAIFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLAMSIEMPYKIEFISSDTHELRQKSTDCKAVISTVEGSSLDSSGFSLHIGLHDAYLPRMWVEKHPEKESEACMLVFQPDLAATLPDLREKNEVIICLDCSNSMEGVTFMQAKQVALYALSLVGEEQKVNIMQFGTGYKELFSYPKYIANNKMATEFIMSAAPTLGNTDFWKILRYLSFLYPSEGLRNILLISDGHLQSENLTLQLVKRNIQHTRLFTCAVGSTANRHILRTLSQCGAGVFEYFNSKSKQSWKKQIEAQMTRIRSPSCHSVSVKWQQLSRDAPEPLQAPAQVPSLFHNDRLLVYGFIPHCTQATLCAFIQEKEFHTMVSTTELQKTTGTMIHKLAARALIRDYEDGVLHDNETNHEMKKKIMKSLIIELSKENSLITQFTSFVAVEKRDGNEIPFANVPNISELVAKEDVDFLPYMSWKEEQPEAFTTLVPEISIQHPVAGDALGSFDSIKPFSVSSERNEKQPLFRKKCKKKIRICGLELSEGFEDMTLEPQSLATAESLKDHSQSKDVDRPSGVIRVEAMKKGTLRTPKLLSAGPVSLGSSASAGFPFHSPCSSQSAFFSPSCHISPIPPAPPRVPSLAGGTLLPPPPPLPGGTLLPPPPPLPGGTLLPPPLPGGTLLPPPPPGGIHLPPSPREFTPFKFGSNMFGQTPKPLGGINISHDLGSSPGQRFVGFGRVASFRSSGDFDLGKGSQDPNVGVFSPKARELDSLHGSLFCTNFMPPICSPTKPPFVPPLPTNVLSSEHPQSPSSLPFLSAKRLGIGRMDPLESALPLAGSPSTASSDKVSSTSSDESSFETDMDEVVCAEGVTLESMKKTSVTSDASSEEDGKFVPYEESCPLPWASLSALQTQDGFWKLTPELGLILKLNVNVLHEFLEEKGIRSLGTKGRDRLLDLIATLLVLQFLRSWLEKEGMVAKSLLKMDDTFISRNIPWAFENIKKASEWATRIEGQYPSICQRLELGKDWESATKQLLGIQPQPNTSLHRILHSNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J987</accession>
    <name>A0A9J7J987_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Regulation of nuclear pre-mRNA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rprd1a</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with the RNA polymerase II complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a heterodimer with RPRD1B. Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UPF0400 (RTT103) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027256387.1">
        <property type="nucleotide sequence ID" value="XM_027400586.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J987"/>
    <dbReference type="GeneID" id="100767756"/>
    <dbReference type="CTD" id="55197"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001111">
        <property type="term" value="P:RNA polymerase II promoter clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17011">
        <property type="entry name" value="CID_RPRD1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000007">
        <property type="entry name" value="Regulation of nuclear pre-mRNA domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032337">
        <property type="entry name" value="RPRD1A/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047884">
        <property type="entry name" value="RPRD1A_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF2">
        <property type="entry name" value="REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16566">
        <property type="entry name" value="CREPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027256387.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37855" checksum="FFACABE5FB4CF0E3" modified="2023-06-28" version="1">MSAFSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVWERELRKAKPNRKLTFLYLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYENDVLEQLKHALYGDKKTRKRTYEQIKVDENENCSSLGSPSEPPQTLDLVRALQDLENAASGDAAVHQRIASLPVEVQEVSLLEKITDKESGERLSKMVEDACMLLADYNGRLAAEIDDRKQLTRMLADFLRCQKEALAEKEHKLEVRIGHGVSSKDVIIISIFFRLKINIKLQSLYCLMFLKIEEQSFIILFIPAFSLLVLTIIGFKNRIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J9T7</accession>
    <name>A0A9J7J9T7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Disintegrin and metalloproteinase domain-containing protein 26A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100774518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007650342.2">
        <property type="nucleotide sequence ID" value="XM_007652152.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246825.1">
        <property type="nucleotide sequence ID" value="XM_027391024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J9T7"/>
    <dbReference type="GeneID" id="100774518"/>
    <dbReference type="KEGG" id="cge:100774518"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990913">
        <property type="term" value="C:sperm head plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF239">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 26B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="234"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="10">
        <location>
            <begin position="432"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
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        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="386"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027246825.1"/>
        </source>
    </evidence>
    <sequence length="795" mass="89897" checksum="7D3BB7EFA71CE680" modified="2023-06-28" version="1">MEEETGIQSLLPLRIYEDSYFSWGEDIVTVGEVLVHERIMVFQLCLWMVLFLSPWSLTEHTKYSSPPEVVIPLRVTDTRRHDSSPGWLSYSLRFGGERHIITMKPTKYFISRNFLLLTYTDKDDLLAEQPFVQSDCYYHGDVDGDPESMVSLTTCLGSLQGILEINGAVYEIMPKSSTSTFEHLLYQMKSEETESRPMRCGLTEEEIAQQMKLQDNHNDTLMQSHYEGWWTHHKYIEYFVVLDNKRFVYTGSNVTRSSNEVLAVFNGMKGYYVSIEIDLIFAGLEIWTEQNYVKVEGNVISVLVSFCQWKERTNKARNQYDIIHLWAKEGYGTNLGISYIGSVCISDSNCAINSFLWDTLGPVSFSIAHELGHNLGMPHDQKNCVCGQEKCIMFKEMTMSTAFSNCSYAAMWDRISQRTCLRNIANDALTPPASCGNTLVEEGEQCDCGSLESCKDDPCCSQHCVVKPGAECATGPCCKNCKFMKPGTLCRGMNDECDLPEWCNGTSAECPEDVFREDASPCNGGFCYKKACNTHNKHCQKIFGMGARSTNETCYMDMNKRGDRFGNCGNNSYNYKKCSDSDILCGRIQCEDVTELPRLQNHVTVYWTHLNTAICWTTEYHFGINTADIGAVRDGTPCGPKHICINRRCVDMPILLSNCSEILCNMQGVCNNKHHCHCNDEWKPPDCVLSGFGGSIDSGPPPVRLSKKQLIRYILGVSVLFPILICCFICINRRIKKRIAGEETRSTTETRSTTETRSTTETTKPKPKSLEKQKPTLKVSPEKGDANEKHKAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JAB5</accession>
    <name>A0A9J7JAB5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LOW QUALITY PROTEIN: transcription factor SOX-21-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC113833262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027249744.1">
        <property type="nucleotide sequence ID" value="XM_027393943.2"/>
    </dbReference>
    <dbReference type="GeneID" id="113833262"/>
    <dbReference type="KEGG" id="cge:113833262"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="transcription factor Sox-2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF313">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027249744.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="28549" checksum="BFE9EC406D1F06BC" modified="2023-06-28" version="1">MSKPVDHVKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYGLGGVADAEHPALKAGGGLHAGAGAGLVPESLLANPEKAAAAAAAAAARVFFPQSAAAAAAAAAAAXGSPYSLLDLGSKMAEISSSSSGLPYASSLGYPTAGAGAFHGAAAAAAAAAAAAGGHTHSHPSPGNPGYMIPCNCSAWPSPGLQPPLAYILLPGMGKPQLDPYPAAYAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JB90</accession>
    <name>A0A9J7JB90_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 24">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 24">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">Kat6a</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 24">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 24">Nucleus</location>
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    </comment>
    <comment type="similarity">
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="PHD2_KAT6A_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone acetyltransferase"/>
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        <property type="entry name" value="Histone acetyltransferase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HAT_MYST-type"/>
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    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
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        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT6A"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0012">Acyltransferase</keyword>
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    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 23 24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
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            <begin position="262"/>
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    <feature type="domain" description="MYST-type HAT" evidence="28">
        <location>
            <begin position="503"/>
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        <location>
            <begin position="334"/>
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    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="439"/>
            <end position="466"/>
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    <feature type="region of interest" description="Disordered" evidence="25">
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            <begin position="982"/>
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            <begin position="1789"/>
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            <begin position="445"/>
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        <location>
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            <begin position="1133"/>
            <end position="1144"/>
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        <location>
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            <begin position="1201"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00048017"/>
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            <dbReference type="PIRSR" id="PIRSR602717-51"/>
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        <source>
            <dbReference type="RuleBase" id="RU361211"/>
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    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
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    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
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    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
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    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
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    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027251081.1"/>
        </source>
    </evidence>
    <sequence length="1994" mass="224012" checksum="E4027D91CAAA324C" modified="2023-06-28" version="1">MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDTKQSVDWNKLLKRAFEGLAESGGSTLKSIERFLKSQKDVSAAYGGSAASGFHQQLRLAIKRAVGHGRLLKDGPLYRINTKAASADGKEGCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSTELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKIPISSQSASSSEEGYLERIDGLDFCRDSNVPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKKGNRKSSTSDWPTDNQDGWDSKQENEERLFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGVCPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEDADEGDREEPQGQERELETTVRVGKSLSRENKDQDSSSSIESEKKPEVKELSSSSRLSKQVLPRDSLPANSQPLRRGRCTRKNRKTQERFGDKDSKVLVDETSTPQEQYGECEEKSEASQEQYPEIEEHSAACQVQPDGKADIPKGRLSESVELWRGQLKKSPETLKCRVPEGNDRLPCCYSDGDRAVFRGFSESSEEEEEPESPRSNSPPILTKPTLKRKKPILHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEDEDENELFPRGYFHRLSSQDVLRCQSSSKRPSKDEEEEEESDDVDDTPILKPVSLLRKCDVNSASLEPDTSTPMKKKKGWPKGKSRKPIHWKKRPGRKPGFKLNQEIIAVSTKECIIEPIVPIKPGRKPRTQENEEMVEVKEDLPLLEERKEEMHTEADEEEEDTTSSDIRAMSPLDSSNSPEAEPKEPEADEEDEKPLEEQRQSEEEPQELEEQEQEEDDEVTAEANQNEDHDADDEDDGHLESLKTKEPEEQPAREDHKEEPGIPESFLDANMQDSRENTKDKDETEPDSEEEQPSHEASVVSETMPGSEEDHEEDSNTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTHTDEDPQMSMVEDCHASEHNSPISSIPSHPSQSVRSVSSPSVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGSSICGNNSSQSSCSYGGLSSSSSLTQNSCVVTQQMANIGNSCSMLQQNSVQPATNCNIKSPQTCVVERPPSNQQPPPPPPPPPPPQQQQQQQQPAPQPPPPQPQQQQQPPPPQQQPQPPPPPQQQPPLSQCSMNNSFTTAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAPLAPSHPLAGAPQAQATMTPPPNLASPTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSATAHQQQLYGRSPPAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JH76</accession>
    <name>A0A9J7JH76_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lymphocyte antigen 6D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Ly6d</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027259613.1">
        <property type="nucleotide sequence ID" value="XM_027403812.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JH76"/>
    <dbReference type="GeneID" id="100774259"/>
    <dbReference type="KEGG" id="cge:100774259"/>
    <dbReference type="CTD" id="8581"/>
    <dbReference type="OrthoDB" id="9449056at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030098">
        <property type="term" value="P:lymphocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23542">
        <property type="entry name" value="TFP_LU_ECD_Ly6D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000003">
        <property type="entry name" value="lymphocyte antigen 6E isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018363">
        <property type="entry name" value="CD59_antigen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042339">
        <property type="entry name" value="Ly6D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035076">
        <property type="entry name" value="Toxin/TOLIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16982">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16982:SF2">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00087">
        <property type="entry name" value="Toxin_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00983">
        <property type="entry name" value="LY6_UPAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039900113" evidence="7">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="8">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027259613.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13225" checksum="F7337B3437B6FE31" modified="2023-06-28" version="1">MKTALLLLLAVAVATSPACALRCHVCSSSTNCKQPQTCPASSQYCKTVTTVDTLTGNLVKKDCVDSCTSNNSQQGQISSGSWVTQCCQGDLCNERLYSAAPARALFSNATLGLAISLGFLALMVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JHA6</accession>
    <name>A0A9J7JHA6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caspase recruitment domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Card10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10. Interacts with TMEM43; this interaction is essential for EGFR-mediated NF-kappa-B activation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027259753.1">
        <property type="nucleotide sequence ID" value="XM_027403952.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JHA6"/>
    <dbReference type="GeneID" id="100762588"/>
    <dbReference type="KEGG" id="cge:100762588"/>
    <dbReference type="CTD" id="29775"/>
    <dbReference type="OrthoDB" id="8868836at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050700">
        <property type="term" value="F:CARD domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08807">
        <property type="entry name" value="CARD_CARD10_CARMA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000143">
        <property type="entry name" value="Caspase recruitment domain family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000867">
        <property type="entry name" value="Caspase recruitment domain family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000003">
        <property type="entry name" value="Caspase recruitment domain family, member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042140">
        <property type="entry name" value="CARD_CARD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559:SF12">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="8">
        <location>
            <begin position="72"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="388"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027259753.1"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121751" checksum="E95743B3B4D2164B" modified="2023-06-28" version="1">MWGGSGGRGAGGGANDPEGTAPSRRRSRRPSTEPAAQGSCGARDSEDAAMQGRADAGEADEEAGAGSGSEAEEDALWERIEGVRHRLTRALNPAKLTPYLRQCRVLDEQDEEEVLSTYRFPCRANRTGRLIDILRCRGKRGFEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRALEEERAGLEQRLREQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPLPGPEDKEEPDGADLLSELRAENQRLTASLQELQEGLQQEVSRPGASGSERILLDILEHDWREAQDSRQELCQKLHTVQGELQWAEELRDKYLQEMEDLRLKHRTLLKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTVTSLEGTKAMLEAQLQRAQGGSCLKACTSSHSLCSNLSSTWSLSEFPSPLGGPEATGEAGGSEAHTSAPGLICELRAEMGGLEVTGLILGLQEEATDSEKEINRLSILPFPPSAGSILRRQREEDPEPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDLLNRSLAIRVSGWSPSGGLELQDKSPDSLPVIGDRWSGAMVRRVLSGPGSARTEQKEPRAEGTGLEGSGLEAEAQQRTLPWNQGSTLPFLLDSKACQSFHEALDAWAKGSGTEPFYIRANLSLPERADPHALCVKAQEILRLVDAAHKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLLSSRHRSPRSNLKKRALGLVRPKPAGGAAGDSAEQLPAELCSELERSLKPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAAESFSGEEQCTSSAPGAPKAWPSTPGLGNRIRAIQESVGKKKHCLLELGARGVKELVQSEVYPIVIHVEVTEKNVREIRGLLGRPGWRDSELLRQCRGSEQWLWGLPCSWVQVPAHAWGHAEELAKVVRGRILQEQARLVWVERGSSRGGCGSSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JIF8</accession>
    <name>A0A9J7JIF8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="19">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">Prkd1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="19">Activated by DAG and phorbol esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 19">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="19"/>
    <dbReference type="RefSeq" id="XP_027272091.1">
        <property type="nucleotide sequence ID" value="XM_027416290.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JIF8"/>
    <dbReference type="GeneID" id="100762119"/>
    <dbReference type="KEGG" id="cge:100762119"/>
    <dbReference type="CTD" id="5587"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010647">
        <property type="term" value="P:positive regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023056">
        <property type="term" value="P:positive regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20839">
        <property type="entry name" value="C1_PKD1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20842">
        <property type="entry name" value="C1_PKD1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01239">
        <property type="entry name" value="PH_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14082">
        <property type="entry name" value="STKc_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000151">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000056">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000137">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000007">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015727">
        <property type="entry name" value="Protein_Kinase_C_mu-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057764">
        <property type="entry name" value="Ubiquitin_PRKD1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25525">
        <property type="entry name" value="Ubiquitin_PRKD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000552">
        <property type="entry name" value="PKC_mu_nu_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 19 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="26">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="26">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="24">
        <location>
            <begin position="423"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="584"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="590"/>
            <end position="598"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 22">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000552-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000552-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027272091.1"/>
        </source>
    </evidence>
    <sequence length="913" mass="102045" checksum="8156A66BC2BB22D3" modified="2023-06-28" version="1">MSAPPLLRRPLLPARPPAAAAAALVPAPGRAVPALGRPAGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGLYDKILLFRHDPTSENILQLVKMASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGLSTVRTSSAEFSTSAPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSYIGRPIQLDKILMSKVKVPHTFVIHSYTRPTVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDIVMEEGSDDNDSERNSGLMDDMDEAMVQNAEMAMAEGQGDGAEMQDPDADQEDSNRTISPSTSNNIPLMRVVQSVKHTKRRSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILCLEPAKPSALIPIGANPHCFEITTANVVYYVGENVVNPSSPPPNNSVFTSGIGADVARMWEVAIQHALMPVIPKGSSVGSGTNLHKDVSVSISVSNCQIQENVDISTIYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDSRWEQYAGDQGLQYPAHLISLSASHSDSPEAEEREMKALSERVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JKH5</accession>
    <name>A0A9J7JKH5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="22">LOW QUALITY PROTEIN: attractin-like protein 1 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC100764329</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262697.1">
        <property type="nucleotide sequence ID" value="XM_027406896.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100764329"/>
    <dbReference type="KEGG" id="cge:100764329"/>
    <dbReference type="OrthoDB" id="9998912at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03597">
        <property type="entry name" value="CLECT_attractin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000079">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000164">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000022">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000036">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000008">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000013">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034011">
        <property type="entry name" value="Attractin-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF4">
        <property type="entry name" value="ATTRACTIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1231"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="94"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="756"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="19">
        <location>
            <begin position="1015"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1350"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1044"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027262697.1"/>
        </source>
    </evidence>
    <sequence length="1380" mass="152278" checksum="A54A4DD80AFF59A0" modified="2023-06-28" version="1">MDPGGRARXGAPQPAAPGLCRARAAGGGGGASSRLLLLDGRSWLLSYGFLYLALYAQVSQSKPCERTGSCFSGRCVNSTCLCDPGWVGDQCQHCQGRFKLTEPSGYLTDGPINYKYKTKCTWLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLVAVLSGLIVPEVRGNETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINSCPNNCSGHGKCTASVLVASQVYCECDKYWKGEACDIPYCKANCGSPDHGYCDLTGEKLCVCNDSWQGPDCSLNVPSTESYWILPNVKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVLNYNLESSIWNVGAVSRGPLQRYGHSLALYQENIFMYGGRIETSDGNVTDELWVFNIPSQSWSTKTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIVIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQGGYGHTSVYDEVTKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFARYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKTLPKPNLHRDVNRFGHSAVVINGSMYIFGGFSSVLLSDVLVYKPPDCRAFQDEELCRNAGPGIKCVWNKNHCESWETGNANTILRAKCPPKTAALDDRCYRYADCASCTANTNGCQWCDDKKCISANSNCSMSVRNYTKCHVRNEQICNKLTSCKSCSLNLNCQWDQRQQECQALPAHLCGEGWNHVGDACLRINSSRESYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQQKVSPWVGLRKINVSYWGWEDMSPFTNTTLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMADGLVCEKPVVSPNQNARPCKKPCSLRTSCSNCTSNGMECMWCGSTKRCVDSNAYIISFPYGQCLEWQTATCSPQNCSGLRTCGQCLEQPGCGWCNDPSDTGRGYCTEGSSRGPMRLGGAHGSEVALDTSLCPKEKNYEWSFIQCPACQCNGHSTCIDSNVCEQCKNLTTGKQCQDCMPGYYGDPTNGGQCTACTCSGHANICHLHTGKCFCTTKGIKGDQCQLCDSENRYVGNPLRGTCYYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGSTGGTISGEETPIVSKTNIREYRDSFSYEKFNFRSNPNITFYVYVSNFSWPIKIQIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVELEVGAEQTDFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDTSQQKPSDNKDKTSGVRNRKHLSTRQGTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JMT0</accession>
    <name>A0A9J7JMT0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH2 domain-containing protein 3C isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Sh2d3c</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027279586.1">
        <property type="nucleotide sequence ID" value="XM_027423785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JMT0"/>
    <dbReference type="GeneID" id="100759629"/>
    <dbReference type="KEGG" id="cge:100759629"/>
    <dbReference type="CTD" id="10044"/>
    <dbReference type="OrthoDB" id="2412973at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10337">
        <property type="entry name" value="SH2_BCAR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000007">
        <property type="entry name" value="SH2 domain containing 3C (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000013">
        <property type="entry name" value="SH2 domain-containing protein 3C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051853">
        <property type="entry name" value="SH2-Ras-GEF_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044102">
        <property type="entry name" value="SH2_SHEP1/BCAR3/NSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247:SF6">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="239"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="603"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027279586.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="96908" checksum="309B074967F99214" modified="2023-06-28" version="1">MTEMPKKTGKKFKFFKFKGLGSLSNLPRSFSLRRSSASISIRSYLEPDTFEATQDDMVTVPKSPPAYARSSDMYSHMGTMPRPNIKKVRQQQAAQKAQEVSLQSHLVPQGLEAAKEAVERKDAPLEDTPGVGPTPSAVEVDPLRKPEEPRVDTKEEQIPGDVYPERATGELEAAGDYVKRTGFQPFTATLGLCGAGHQTRGLLQFSKEKYILDSSPEKLHKELEEELKLNSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWHNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLSQASSKAASPVSPSGSKGSHMKRRSITMTDGLTTDKVTRSDGCPNSTSLPHPRDSIRNCALSMDQIPDLHSPLSPISESPSSPAYSTVTRVHAAPTTPSTTAPPASPVARRPSEPQSSHGSTPKPPVESDKPHASPSHTLCKASRSPSLNSYSDPDSGHYCQLQPSVRGSREWAAGETPRKTRSSGERQKELSENGVSDGEWGKPFAVPVVEATSSFNLATFQSQLIPKENRPLEVGLLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALEMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKGLNEGKESLPLSNTTFPHVLPFITLLECDSAPTEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEAKLQGFQARPELLEVFSTEFQMRLLWGSQGANSSQARRYEKFDKVLTALSHKLEPAIRSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JPD7</accession>
    <name>A0A9J7JPD7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase LMTK2</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Brain-enriched kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Lemur tyrosine kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Lmtk2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Phosphorylates PPP1C, phosphorylase b and CFTR.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PPP1C and inhibitor-2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_027269404.1">
        <property type="nucleotide sequence ID" value="XM_027413603.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100769717"/>
    <dbReference type="KEGG" id="cge:100769717"/>
    <dbReference type="CTD" id="22853"/>
    <dbReference type="OrthoDB" id="5973359at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05086">
        <property type="entry name" value="PTKc_Aatyk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000275">
        <property type="entry name" value="Apoptosis associated tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000386">
        <property type="entry name" value="serine/threonine-protein kinase LMTK2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE LMTK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417:SF8">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE LMTK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039951912" description="Serine/threonine-protein kinase LMTK2" evidence="21">
        <location>
            <begin position="28"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="137"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="581"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="957"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1002"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1266"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1362"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="957"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="974"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1188"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1374"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="1398"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1419"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027269404.1"/>
        </source>
    </evidence>
    <sequence length="1491" mass="162275" checksum="3CD3C9A7636265F7" modified="2023-06-28" version="1">MPGPPASSPPPVLLLLLLLLTVGSARAAPLPQTGAGEAPVSEVPSLFVILSVCSLMILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQSSVEGLKSQVARHSLNYIQEIGSGWFGKVLLGETYTGTSVARVIVKELKASASPKEQDTFLKNGEPYYILQHPNVLQCVGQCVEAIPYLLVFEFCDLGDLKAYLRNEQEHVRGDSQTMLLQRMACEIAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFSNAAQPYANLSDLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLAPDKRPAAEDVHRLLTYLRMQSQRDSEVDFEQQWTALKPNTSSRDTSSSAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHNHFDEQGRGHPDEALSYSSMFFPVEVFESSLSDPGPGKQDDSGQEVPLRAPGVVPVFDAHNLSVGSDYYIQLEEKSSSNLGLDYPPVLLTTEVDNTERVGAEAPQPMALKNPVSEEPSAGDDFFQSSTHPKEPSSSEDSHAASIPGSPFNIFNDLDKADDLPSHQKIFDLMELNGVQADFKPATLSSSLDDPKDTCHSDKEKSHKLFDQDPVCLSESLLHQDHFDPLSVQELSENFLFLQEKNLLKGSVPNKEPVNDLQTEFKNAGFTSALLDSPQRGSQGSEVEFPENTLDFPLSQENMSGENEGTGIMLQGSTSPQASPEVQGPLASLTEEASPNGLLDKVLRPGETKSFVDVRVPEGSVCLDLSPNPMTAPDEIPSTDAKIDDEVTGPPDITCQSNKAMILTKRDSILVNDSLAGQGSMGSSLPESRQDLQNQPFSEVLLSGSILERSLVAVETSNQLNYKAVPKDAASALSSDSTSQDSLLEDSLSTPIPTSEQSVETPDSLDSVDVHEALLESLGSHTPQKLLPPDKPADSGYETENLESPEWTLHPAPEGATDSDVAAAGDSGQNSLPPNPVIVISDAGDGQRGAEGPPQSFTLGTQSSYRDSAYFSDNDSEPDKKPEEVPVSSPSALAFVKDQSAPEPVVPEESSDIGDSCLQAPQSKPNQSEVSAVQNSCHSELQEMLQPTPADGSRETFPVDDEASSPLSLLNSELSSCDDLETQEDRPCTLASTGTNTNELLAYASSTLDKSMSSPFEGPKIKEPDIEGKYLGKLCVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDDTEHPVPIIVSNDDGRHLRSLLKPSATEAPKQLPDEWKKEKKAVTFFDDVTVYLFDQETPTKELGHCGGEAHGPGPSSPTASSGSPYLGRCMNSESSTDEEGGGFEWDDDFSPDPFMSKTTSLLGSKPSLQSSKYFSPPPPARSAEQSWPHVSPCSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUE9</accession>
    <name>A0A9J7JUE9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Regulator of chromosome condensation</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chromosome condensation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Rcc1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with RAN. Interacts with KPNA3. Interacts (via N-terminus and RCC1 repeats) with KPNA4. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007625066.1">
        <property type="nucleotide sequence ID" value="XM_007626876.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016825985.1">
        <property type="nucleotide sequence ID" value="XM_016970496.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295446.1">
        <property type="nucleotide sequence ID" value="XM_035439555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JUE9"/>
    <dbReference type="GeneID" id="100769945"/>
    <dbReference type="CTD" id="1104"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000008">
        <property type="entry name" value="regulator of chromosome condensation isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF9">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="21">
        <location>
            <begin position="83"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="132"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="237"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="305"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="359"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035295446.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="50296" checksum="E97A4A36AFDAD648" modified="2023-06-28" version="1">MQFGKVVCIRSSTQNFVKLGKHLFIAVLSLERKMPPKRIAKRRSPPEDAIPKSKKVKDPRNRGPAARSCQVSHRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVTVLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSAEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDMPVVKVASGNDHLVMLTTEGDLYTLGCGDQGQLGRVPELFANRGGRQGLERLLVPRCVLLKARGCRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPIVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQEEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUP9</accession>
    <name>A0A9J7JUP9_CRIGR</name>
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        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
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    <gene>
        <name evidence="14" type="primary">LOC100769209</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027421077.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="100769209"/>
    <dbReference type="KEGG" id="cge:100769209"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276878.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35207" checksum="E89684360000BEAE" modified="2023-06-28" version="1">MGQRNNVTEFILLGLTQDPTGQKVLFAMFLIIYIVTMVGNLLIVGTVVASPSLNSPMYFFLAFLSIMDAVYSTSTTLKLVMDLLSEKKTISFTACMGQLFTAHLTGGAEVFLLVVMAYDRYVAICKPLHYLTIMNRKICILLLVIAWVGGFAHSVVQVIFVSNLPFCGPNVIDHFICDMYPLLTLACSDTYFIGLTVVANGGAICMIIFILLLISYAFILNSLKSYSQEGRRKALSTCGSHITVVVLFFVPCIFIYVRPVSNFPIDKSISVVFTAFTPMLNPLIYTMRNSEMKNAMQKLWCKKLTTYRIRVHSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JV15</accession>
    <name>A0A9J7JV15_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Olfactomedin-like protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Olfml2a</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279449.2">
        <property type="nucleotide sequence ID" value="XM_027423648.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JV15"/>
    <dbReference type="GeneID" id="100750647"/>
    <dbReference type="KEGG" id="cge:100750647"/>
    <dbReference type="CTD" id="169611"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF29">
        <property type="entry name" value="OLFACTOMEDIN-LIKE PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039897450" evidence="5">
        <location>
            <begin position="28"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="6">
        <location>
            <begin position="392"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027279449.2"/>
        </source>
    </evidence>
    <sequence length="650" mass="73484" checksum="2BABFC185513E648" modified="2023-06-28" version="1">MAAATLLPWCPQLKLLLLLLLLFLLRAGPVQPDSKIFSNLDQVRMTSEGSDCRCKCIMRPLSKDACSRVRSGRGQIEDFYTVETLSSGTDCRCSCTAPPSSLNPCENEWKMEKLKKQAPELFKLQSMVDLLEGALYSVDLMKVHAYIHKVASQMNTLEENIKANLSQENEVVKDSIRHLGEQLKRYENQSAIMMSIKKELSSLGLQLLQRDAAAVPATAPDSSPDSKAQDTAGRQGKDLNKYGSIQKSFSDKGLAKPPKEKLLKVEKLRKESIKARIPHPTARPHALAQQQAVVQSFTYYKAARQEAKKEAPKATADNTLKGTSWLGKVPPKMETKLPEPNSAKHNGVMPQPSEGASLVPDISTSTPTPITTLWPKEPHLHPENPSQGREDSCEGTLGAVDPPVKHHSYGRHEGAWMKDPTALDDRIYVTNYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHVVYQGAFYYNRAFTKNIIKYDLHQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAVDEQDETQHEVIVLSRLDPGDLSVHQETTWKTRLRRNSYGNCFLVCGILYAVDTYNQREGQVAYAFDTHTGTDAHPQLSFLNEYSYTTQVDYNPKERVLYAWDNGHQLTYTLNFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JW28</accession>
    <name>A0A9J7JW28_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Rexo4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027278801.1">
        <property type="nucleotide sequence ID" value="XM_027423000.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JW28"/>
    <dbReference type="GeneID" id="100770295"/>
    <dbReference type="KEGG" id="cge:100770295"/>
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    <dbReference type="OrthoDB" id="8191639at2759"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
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        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF158">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="231"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027278801.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46622" checksum="EDB1D834EDA5591A" modified="2023-06-28" version="1">MKAKATAPVSQPEPIKELVRKKARKRFRKSKAQGGSVAPGSLPAAVAVRPPKAPENFSQNWKALQELLKQKSQAPEKPLVSQMDDKMHPQIIQQNKKETSDKAKGDGKRTEKDQTIKGSVTALSKKDRKRPVPPTNSSGPEQKKSAQKRTFSDNASHQEDIKHKWKAKEVAVVLNQSSPTEEDIWFDDVDPDDIEAAIGPEAAMLVRKRLGQKSKSTISLVKEQAFGGLTKALALDCEMVGVGPKGEESIAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPENLKQGEEFEVVKKEVAEMLKGRTLVGHALHNDLKVLFLDHPKKKIRDTQKFKPFRSQVRSGKPSLKQLSEKILGIRVQQAEHCSIHLKCQHPAWCSPHCPWDETWGAGIPRGVRSYCLGHCEQKGCLPAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JXE5</accession>
    <name>A0A9J7JXE5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Ccdc154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027280615.1">
        <property type="nucleotide sequence ID" value="XM_027424814.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027291743.1">
        <property type="nucleotide sequence ID" value="XM_027435942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JXE5"/>
    <dbReference type="GeneID" id="100764550"/>
    <dbReference type="KEGG" id="cge:100764550"/>
    <dbReference type="CTD" id="645811"/>
    <dbReference type="OrthoDB" id="9445857at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035630">
        <property type="term" value="P:bone mineralization involved in bone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029512">
        <property type="entry name" value="CCDC154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15450">
        <property type="entry name" value="CCDC154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="539"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027280615.1"/>
        </source>
    </evidence>
    <sequence length="704" mass="80516" checksum="23730581675C5AED" modified="2023-06-28" version="1">MAQAGWSLTQQELGSGWHLSKITGTATVPEHKLPRCLLLEPADSPSLGLSPSQLSTVTLEDLQLLLTEGLASPKPLSVETSERYECGSRESSSLVPEHDTPKQRKQLEQWVAELQAEVVRLRRHKERCEHATLGLLRELLQVRARVQLQASELRQLRQEVQQAAWSPEKEALELSGPQSQNQIQVLDKRLVEVREALTQIRRTQVLQDSERKCSEQEINLRVTKLTDLLRQEEKGREAACSTLQKNQEDINQKVDLGLAKMQDQVTEFGEEMSIRFLKREAKLCSFLQKCFLAMEQRMKSSESTRLMAESSLREELESHWKKLHELTEERLRALQIHSEEEEGRLLEQCRGLDKAVVYLTKFVRQNQVSLNRVLLAEQKAREAKVSLEENQAGELASYVHENLEAVQMAGKLAQQEMQSELQLLQEKSQVLEGSMARLEQQLKDLSDHCLALNWKLDLQEQTLGLKLSQVQTAWEGVEQDSLQSLTQCLKEISAHLQEMQEKVNSLPQQIESICNKCVLLKSDVDLKISAEGKTRESEVEAVRQELATLLMSVQFLKEENPGRKIAEIQGQLATFQKQIIKLENSLQANKTIQNLKFNNETKLRTEEIATLRESMLSLWSEEGPWPLTLGSKRVFMSLVRQRFFIKDLALGELLPVNSWGLYQAVRWLQWKTVLLNLVAQQRPRTISAMTHWKPAAEIMSLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K1R4</accession>
    <name>A0A9J7K1R4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer dense fiber protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Odf1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027287180.1">
        <property type="nucleotide sequence ID" value="XM_027431379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K1R4"/>
    <dbReference type="GeneID" id="100767282"/>
    <dbReference type="KEGG" id="cge:100767282"/>
    <dbReference type="CTD" id="4956"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001520">
        <property type="term" value="C:outer dense fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06482">
        <property type="entry name" value="ACD_HspB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000026">
        <property type="entry name" value="Outer dense fiber protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037552">
        <property type="entry name" value="ODF1_ACD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037389">
        <property type="entry name" value="ODFP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17125">
        <property type="entry name" value="OUTER DENSE FIBER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17125:SF2">
        <property type="entry name" value="OUTER DENSE FIBER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="SHSP" evidence="15">
        <location>
            <begin position="131"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027287180.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29037" checksum="8DFD570FFD8E016B" modified="2023-06-28" version="1">MAALSCLLDSVRRDIKKVDRELRQLRCIDEISSRCLCDLYMHPYCCCDLHPYPYCLCYSKRSRSCGLCDLYYPCCLCDYKLYCLRPSLRSLERKVTRAIEDDRKMELAELRRTTNRILASSCCSSNILGSVNVCGFEPDQVKVRVKDGKVCVSAERENRYDCLGSKKYSYMNICKEFSLPPCVDEKDVTYSYGLGSCVKIESPCYPCTSPCNPCNPCSPCSPCNPCGPCGPCGPCGPCDPCNPCYPCGSRFSCRKMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K1X2</accession>
    <name>A0A9J7K1X2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100774255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_027290031.1">
        <property type="nucleotide sequence ID" value="XM_027434230.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K1X2"/>
    <dbReference type="GeneID" id="100774255"/>
    <dbReference type="KEGG" id="cge:100774255"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF651">
        <property type="entry name" value="INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="124"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027290031.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="62974" checksum="18D0489011A6C503" modified="2023-06-28" version="1">MTEVQKRQHLGQVHLWSDWQKRVASIHLLPEKSAARCLQVAAGDMEAAQRLSEVESPWKAGTGCKPSSHAVDSEVSSCSYGSADSAWSSPLTQDLHQDNAQGTAELAARGKHSASWERALGVGVGLLNTGNSCYLNAALQCLTHTPPLANYMLSREHSQSCCHHPGSCTMCALEAQVNQSLLHSKDVMQPSKILTGAFHRQKQEDAHEFLMFTLNAMHEACLRGRKPSEESSKDSTPIYEIFGGSWRSQVRCLQCQGTSDAFSPFLDVLLDIHEAHSVKQALEYLVKAEELCGENAYFCDHCQEKTPALKSLAIQGASKVLLLVLNRSSDSAGGKTDRKVRYPESLDLRPYMSQSNRGPLVYALYAVLVHAGATCHSGHYFCYVRAGNGKWYKMDDSTVTRCEVASVLSESAYLLFYVQGTDGRGDSVNRPVGTGNKAHAGKGWQKKHKRRSCVQATEPCREREEAAAQAKSLDQWKVLEENKRPESGLNLQRPGSTPPADGVGIHRARSREDWDRNRPDKENHPWHDSARFPPAPRAMDSGLPCSQEERARSKKKKKKPTWRPLPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K283</accession>
    <name>A0A9J7K283_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">Taz</name>
        <name evidence="17" type="synonym">TAZ</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21">17A/GY</strain>
            <tissue evidence="20 21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)</text>
            <dbReference type="Rhea" id="RHEA:67752"/>
            <dbReference type="ChEBI" id="CHEBI:72840"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74563"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:67753"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:67754"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:68988"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:68989"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:68990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:67748"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:64840"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67749"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:67750"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with multiple protein complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027288194.1">
        <property type="nucleotide sequence ID" value="XM_027432393.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288195.1">
        <property type="nucleotide sequence ID" value="XM_027432394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K283"/>
    <dbReference type="GeneID" id="100758692"/>
    <dbReference type="KEGG" id="cge:100758692"/>
    <dbReference type="CTD" id="6901"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="18">
        <location>
            <begin position="63"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027288194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027288195.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34890" checksum="1C502E3E33065501" modified="2023-06-28" version="1">MPLHVKWPFPAVPRLTWTIASSVVMGLVGTYSCFWTKYMNQLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWVGIGRLIAECHLNPIILPLWHVGGDSESPHRLHSRGIPAAEDAGGTAPQPFPAWKIGFAYPVCAPKSLAKGALGPPGFGKWWYRTLPKLAWLCTAFEFLPCTKLRLGDGPMLLIQIDWLIIPAFLSSFCFETGFLCVALAVLELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3N9</accession>
    <name>A0A9J7K3N9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">H-2 class II histocompatibility antigen, I-E alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100752328</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MHC class II family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307877.1">
        <property type="nucleotide sequence ID" value="XM_035451986.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313925.1">
        <property type="nucleotide sequence ID" value="XM_035458034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3N9"/>
    <dbReference type="GeneID" id="100752328"/>
    <dbReference type="KEGG" id="cge:100752328"/>
    <dbReference type="OrthoDB" id="8925804at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002504">
        <property type="term" value="P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000280">
        <property type="entry name" value="HLA class II histocompatibility antigen, DR alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.320.10:FF:000002">
        <property type="entry name" value="HLA class II histocompatibility antigen, DR alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001003">
        <property type="entry name" value="MHC_II_a_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF59">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00993">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00920">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0491">MHC II</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039918729" evidence="13">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035307877.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28212" checksum="1F0E939709FC7A93" modified="2023-06-28" version="1">MTPSRALILGILALTTALSPCGGQDDIQADHVGLYGLNLYQSHQPNGQYTMEFDDDELFYVDLDKKETIWRIPEFAQLRSFDPQGGLQEIAVAKYNLDILIKETNSTPAANEVPEVTVFPKSPVLLGQPNVLICLVNNIFPPVINITWLRNSKSVTEGVYETSFLSNSDHSFHKMAYLTFIPSDDDIYDCRVEHWGLEEPALKHWEPEVPAPVSELPETVVCALGLSVGIVGIVVGTVFIIQGLRSGGPSRHPGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3U8</accession>
    <name>A0A9J7K3U8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Haptoglobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC100756921</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Tetramer of two alpha and two beta chains; disulfide-linked. The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163. Interacts with ERGIC3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035298556.1">
        <property type="nucleotide sequence ID" value="XM_035442665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3U8"/>
    <dbReference type="GeneID" id="100756921"/>
    <dbReference type="KEGG" id="cge:100756921"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030492">
        <property type="term" value="F:hemoglobin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000048">
        <property type="entry name" value="Haptoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000027">
        <property type="entry name" value="Haptoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000031">
        <property type="entry name" value="Haptoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008292">
        <property type="entry name" value="Haptoglobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF27">
        <property type="entry name" value="HAPTOGLOBIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001137">
        <property type="entry name" value="Haptoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0011">Acute phase</keyword>
    <keyword evidence="9" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0351">Hemoglobin-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0721">Serine protease homolog</keyword>
    <keyword evidence="7 15" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="78"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="14">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (between alpha and beta chains)" evidence="14">
        <location>
            <begin position="65"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001137-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035298556.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36288" checksum="12343025FFC5FC23" modified="2023-06-28" version="1">MDTADDSCPKPPEIENGYVEHLVRYRCRQYYRLRTEGNGVYTLNSEKQWVNTATGERLPECEAVCGKPKHPVDQVQRIIGGFMDAKGSFPWQAKMVSRHKLITGATLISDQWLLTMAKNLYLNHSENAKAKDIAPTLKLYVGKMQPVEIEKVVIHPNRSVVDIGLIKLKQKVLVNETVMPICLPSKDYVAPGRMGYVSGWGRNANFRFTDRLKYVMLPVADQDSCVLHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGLTKYEEDTCYGDAGSAFAIHDMEQDTWYAAGILSFDKSCSVAEYGVYMKVNSFLDWIQETMAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4Z0</accession>
    <name>A0A9J7K4Z0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Nucleoporin SEH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">GATOR2 complex protein SEH1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Nucleoporin seh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25 26">Nup107-160 subcomplex subunit SEH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC113838012</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. The SEH1 subunit appears to be only weakly associated with the Nup107-160 subcomplex. Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids. SESN1, SESN2 and SESN3 convey leucine availability via direct interaction with SEH1L and WDR24.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309551.1">
        <property type="nucleotide sequence ID" value="XM_035453660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K4Z0"/>
    <dbReference type="GeneID" id="113838012"/>
    <dbReference type="KEGG" id="cge:113838012"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000063">
        <property type="entry name" value="SEH1 like nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="19" id="KW-0137">Centromere</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 27" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="27">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="27">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00063713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00069777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00079639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00082440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00083053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_035309551.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37623" checksum="FEA38EA2459CAEB2" modified="2023-06-28" version="1">MFLPRSIETDHKDLIHDVSFDFHGRRMATCSSDHSIKVWDKSESGDWQCTATWKSHNGSVWHVTWAHPEFGQVLASCSFDRTAAVWEEVVGESSKKLRGQSHWVKRTTLLDSRTSVTDVKFAPKHMGLMLVTCSADGIVRIYEAPDVMNLNQWFLEHEISCKLSCSCISWNPSVSRAHSPMIAVGSNDNSPKAMAKVQIFEYNENIRKYAEAETLMTATDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHMVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAIYMDNWKCTGILKHHWSTVNVGSQLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KB70</accession>
    <name>A0A9J7KB70_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carcinoembryonic antigen-related cell adhesion molecule 3-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100771234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the immunoglobulin superfamily. CEA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305000.1">
        <property type="nucleotide sequence ID" value="XM_035449109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KB70"/>
    <dbReference type="GeneID" id="100771234"/>
    <dbReference type="KEGG" id="cge:100771234"/>
    <dbReference type="OrthoDB" id="6353782at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05774">
        <property type="entry name" value="IgV_CEACAM_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000340">
        <property type="entry name" value="Carcinoembryonic antigen-related cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050831">
        <property type="entry name" value="CEA_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427:SF4">
        <property type="entry name" value="PREGNANCY SPECIFIC BETA-1-GLYCOPROTEIN 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039955455" evidence="5">
        <location>
            <begin position="33"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="6">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="6">
        <location>
            <begin position="159"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035305000.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29103" checksum="328746D8CF415585" modified="2023-06-28" version="1">MPSVLLCNGCTPWQGLLLTASLVTFWHYPTTAEHVTIESVPPHVVEGENVLLLVQNLPENLATLVWSKGVKISNNVIGLYDLNKDVSAPGPLHSGRETVYSNGSLLLRNVTWKDTALYTLKCLNRHGDTASTTTIYLEVHSKYTHCGCPCSSAQPTIELVPPSIVEGESVLLVAHNLPENLRSFFWYKGGIVFKNFEIAQHIIATHSTLLGPVHNGRERVYSNGSLLLQNVTWNDIGFYTLRTLSRNMKSELVRVQLQLDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3H309</accession>
    <name>G3H309_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Betaine--homocysteine S-methyltransferase 1</fullName>
            <ecNumber evidence="13">2.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Bhmt</name>
        <name evidence="22" type="ORF">I79_004614</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:22336"/>
            <dbReference type="ChEBI" id="CHEBI:17750"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58251"/>
            <dbReference type="EC" id="2.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:22337"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.5" evidence="13"/>
    <dbReference type="EMBL" id="JH000121">
        <property type="protein sequence ID" value="EGW04217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498744.1">
        <property type="nucleotide sequence ID" value="XM_003498696.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257522.1">
        <property type="nucleotide sequence ID" value="XM_027401721.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H309"/>
    <dbReference type="STRING" id="10029.G3H309"/>
    <dbReference type="PaxDb" id="10029-XP_007634364.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024020.1">
        <property type="protein sequence ID" value="ENSCGRP00001019776.1"/>
        <property type="gene ID" value="ENSCGRG00001019116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754488"/>
    <dbReference type="KEGG" id="cge:100754488"/>
    <dbReference type="CTD" id="635"/>
    <dbReference type="eggNOG" id="KOG1579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003122"/>
    <dbReference type="OMA" id="CKDKTEV"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006577">
        <property type="term" value="P:amino-acid betaine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071267">
        <property type="term" value="P:L-methionine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000003">
        <property type="entry name" value="Betaine--homocysteine S-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051524">
        <property type="entry name" value="BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120:SF2">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="21">
        <location>
            <begin position="11"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="20">
        <location>
            <begin position="347"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGW04217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027257522.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45065" checksum="54F68725748230E0" modified="2011-11-16" version="1">MAPVAGKKAKKGILERLNAGEVVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSEMEVKKIFQQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKTSGKPIAATMCIGPEGDLHGVSPGECAVRLVKAGASIVGVNCHFDPATSLQTVKLMKEGLEGARLKAYLMTQPLAYHTPDCSKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSKPDAWGVTKGTSELMQQKEATTEQQLKELFEKQKFKSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3H4A8</accession>
    <name>G3H4A8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 21 22 23 24" type="primary">Rab3a</name>
        <name evidence="16" type="ORF">H671_1g2629</name>
        <name evidence="15" type="ORF">I79_005108</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Lipid-anchor</topology>
            <orientation evidence="2 13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000137">
        <property type="protein sequence ID" value="EGV97450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE665172">
        <property type="protein sequence ID" value="ERE88997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003499209.1">
        <property type="nucleotide sequence ID" value="XM_003499161.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250536.1">
        <property type="nucleotide sequence ID" value="XM_027394735.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250537.1">
        <property type="nucleotide sequence ID" value="XM_027394736.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284094.1">
        <property type="nucleotide sequence ID" value="XM_027428293.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306408.1">
        <property type="nucleotide sequence ID" value="XM_035450517.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306409.1">
        <property type="nucleotide sequence ID" value="XM_035450518.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307136.1">
        <property type="nucleotide sequence ID" value="XM_035451245.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307138.1">
        <property type="nucleotide sequence ID" value="XM_035451247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H4A8"/>
    <dbReference type="SMR" id="G3H4A8"/>
    <dbReference type="STRING" id="10029.G3H4A8"/>
    <dbReference type="PaxDb" id="10029-XP_007611090.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027256.1">
        <property type="protein sequence ID" value="ENSCGRP00001023011.1"/>
        <property type="gene ID" value="ENSCGRG00001021376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759024"/>
    <dbReference type="KEGG" id="cge:100759024"/>
    <dbReference type="CTD" id="5864"/>
    <dbReference type="eggNOG" id="KOG0093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158959"/>
    <dbReference type="OMA" id="CSMARDI"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060478">
        <property type="term" value="P:acrosomal vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061670">
        <property type="term" value="P:evoked neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903307">
        <property type="term" value="P:positive regulation of regulated secretory pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905684">
        <property type="term" value="P:regulation of plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of presynaptic dense core granule exocytosis"/>
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        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
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        <property type="term" value="P:regulation of synaptic vesicle fusion to presynaptic active zone membrane"/>
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        <property type="term" value="P:respiratory system process"/>
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        <property type="term" value="P:response to electrical stimulus"/>
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        <property type="term" value="P:sensory perception of touch"/>
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        <property type="term" value="P:synaptic vesicle clustering"/>
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        <property type="term" value="P:synaptic vesicle exocytosis"/>
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        <property type="term" value="P:synaptic vesicle maturation"/>
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        <property type="term" value="P:synaptic vesicle transport"/>
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        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ras-related protein Rab-3C"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTPase"/>
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        <property type="entry name" value="Small_GTPase_Rab"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RASTRNSFRMNG"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0488">Methylation</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367096"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV97450.1"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023011.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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            <dbReference type="Proteomes" id="UP000030759"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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        <source>
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    <evidence type="ECO:0000313" key="22">
        <source>
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        <source>
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        <source>
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    <sequence length="220" mass="24970" checksum="1A3E9F8C9D09EB40" modified="2011-11-16" version="1">MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLTDQQAPPHQDCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3H4I0</accession>
    <name>G3H4I0_CRIGR</name>
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        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Hsh2d</name>
        <name evidence="5" type="ORF">I79_005181</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH000137">
        <property type="protein sequence ID" value="EGV97522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007636440.1">
        <property type="nucleotide sequence ID" value="XM_007638250.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250706.1">
        <property type="nucleotide sequence ID" value="XM_027394905.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H4I0"/>
    <dbReference type="STRING" id="10029.G3H4I0"/>
    <dbReference type="PaxDb" id="10029-XP_007627278.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023179.1">
        <property type="protein sequence ID" value="ENSCGRP00001018935.1"/>
        <property type="gene ID" value="ENSCGRG00001018531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760566"/>
    <dbReference type="KEGG" id="cge:100760566"/>
    <dbReference type="CTD" id="84941"/>
    <dbReference type="eggNOG" id="ENOG502RZYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161678"/>
    <dbReference type="OMA" id="CGQKDPA"/>
    <dbReference type="OrthoDB" id="67310at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002903">
        <property type="term" value="P:negative regulation of B cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051902">
        <property type="term" value="P:negative regulation of mitochondrial depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000059">
        <property type="entry name" value="hematopoietic SH2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF3">
        <property type="entry name" value="HEMATOPOIETIC SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV97522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027250706.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37424" checksum="0170662C8D6FC378" modified="2011-11-16" version="1">MAEAWRPPLPLPPRLDWFVHTQVDQLAQYGIPEWFHGTISREVAENLLESQPLGTFLIRVSHSHVGYTLSYKAQTCCRHFMVKLSDDGTFILAGDHVTHASLDALVTFHQQKPIRPYRELLTQACGQKDPANVDYEDLLLYSNALVQDAESRGPTEVQRPSSCPPEEAPERRPNAATDGKLPSAPCSPKAHFGEAGQKLWKNLRTLPETSRRVKQRLTSHLSATNLLGDARRVVQHCSPVTRVSSWDSASHSKDPGAATSLQNLSEPQAQRSRESTFTASRPASWKEAVSGVRAWRGKVARALSVQATKSEPEDLPEAQDWLPEEYLRPPPFAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3H6M6</accession>
    <name>G3H6M6_CRIGR</name>
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        <recommendedName>
            <fullName evidence="8">Gremlin</fullName>
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    <gene>
        <name evidence="13 16" type="primary">Grem2</name>
        <name evidence="12" type="ORF">I79_005992</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
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            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH000177">
        <property type="protein sequence ID" value="EGW05763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300878.1">
        <property type="nucleotide sequence ID" value="XM_035444987.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310039.1">
        <property type="nucleotide sequence ID" value="XM_035454148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H6M6"/>
    <dbReference type="SMR" id="G3H6M6"/>
    <dbReference type="STRING" id="10029.G3H6M6"/>
    <dbReference type="PaxDb" id="10029-XP_007620981.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002742.1">
        <property type="protein sequence ID" value="ENSCGRP00001002153.1"/>
        <property type="gene ID" value="ENSCGRG00001002244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773984"/>
    <dbReference type="KEGG" id="cge:100773984"/>
    <dbReference type="CTD" id="64388"/>
    <dbReference type="eggNOG" id="ENOG502QZFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154209"/>
    <dbReference type="OMA" id="YIPRHIK"/>
    <dbReference type="OrthoDB" id="10061784at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048263">
        <property type="term" value="P:determination of dorsal identity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010172">
        <property type="term" value="P:embryonic body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017159">
        <property type="entry name" value="Gremlin-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF2">
        <property type="entry name" value="GREMLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037254">
        <property type="entry name" value="Gremlin_precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6 9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044536643" description="Gremlin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="11">
        <location>
            <begin position="73"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9 10">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGW05763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035300878.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19334" checksum="6361C1581D49C281" modified="2011-11-16" version="1">MFWKLSLTLLLVAVLVKVAETRKNRPAGAIPSPYKDGSSNNSERWHHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEDSFQSCAFCKPQRVTSVIVELECPGLDPPFRIKKIQKVKHCRCMSVNLSDSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3H7Y7</accession>
    <name>G3H7Y7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G protein-activated inward rectifier potassium channel 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inward rectifier K(+) channel Kir3.3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Potassium channel, inwardly rectifying subfamily J member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 27" type="primary">Kcnj9</name>
        <name evidence="23" type="ORF">I79_006483</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Associates with KCNJ3/GIRK1 to form a G-protein-activated heteromultimer pore-forming unit. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000204">
        <property type="protein sequence ID" value="EGV93403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301511.1">
        <property type="nucleotide sequence ID" value="XM_035445620.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310293.1">
        <property type="nucleotide sequence ID" value="XM_035454402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H7Y7"/>
    <dbReference type="STRING" id="10029.G3H7Y7"/>
    <dbReference type="PaxDb" id="10029-XP_007609584.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001287.1">
        <property type="protein sequence ID" value="ENSCGRP00001001258.1"/>
        <property type="gene ID" value="ENSCGRG00001000969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764245"/>
    <dbReference type="KEGG" id="cge:100764245"/>
    <dbReference type="CTD" id="3765"/>
    <dbReference type="eggNOG" id="KOG3827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01080000257365"/>
    <dbReference type="OMA" id="RFSPMML"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902937">
        <property type="term" value="C:inward rectifier potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098688">
        <property type="term" value="C:parallel fiber to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015467">
        <property type="term" value="F:G-protein activated inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099505">
        <property type="term" value="P:regulation of presynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000019">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003276">
        <property type="entry name" value="K_chnl_inward-rec_Kir3.3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF17">
        <property type="entry name" value="G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01329">
        <property type="entry name" value="KIR33CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 18" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="5 18" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="21">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="22">
        <location>
            <begin position="171"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="17">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV93403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_035301511.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43979" checksum="4C221AAA9885F180" modified="2011-11-16" version="1">MAQDNAAFSPVSEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGGGDGADKEQNGCLPPPESESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3HA80</accession>
    <name>G3HA80_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein sel-1 homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Suppressor of lin-12-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Sel1l</name>
        <name evidence="21" type="ORF">I79_007325</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer and homooligomer. May form a complex with ERLEC1, HSPA5, OS9, and SYVN1. Interacts with FOXRED2 and EDEM1. Interacts with LPL and LMF1; may stabilize the complex formed by LPL and LMF1 and thereby promote the export of LPL dimers. Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1. SYNV1 assembles with SEL1L and FAM8A1 through its transmembrane domains, but interaction with its cytoplasmic domain is required to confer stability to FAM8A1 and enhance recruitment of HERPUD1. The interaction with SYNV1/HRD1 is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000245">
        <property type="protein sequence ID" value="EGW05827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003501029.1">
        <property type="nucleotide sequence ID" value="XM_003500981.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274448.1">
        <property type="nucleotide sequence ID" value="XM_027418647.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HA80"/>
    <dbReference type="STRING" id="10029.G3HA80"/>
    <dbReference type="PaxDb" id="10029-XP_007618151.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030748.1">
        <property type="protein sequence ID" value="ENSCGRP00001026502.1"/>
        <property type="gene ID" value="ENSCGRG00001023783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751353"/>
    <dbReference type="KEGG" id="cge:100751353"/>
    <dbReference type="CTD" id="6400"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156671"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036513">
        <property type="term" value="C:Derlin-1 retrotranslocation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000208">
        <property type="entry name" value="Protein sel-1 homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000193">
        <property type="entry name" value="protein sel-1 homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000200">
        <property type="entry name" value="protein sel-1 homolog 1 precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF70">
        <property type="entry name" value="PROTEIN SEL-1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 19" id="KW-0732">Signal</keyword>
    <keyword evidence="2 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732129" description="Protein sel-1 homolog 1" evidence="19">
        <location>
            <begin position="22"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="20">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGW05827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027274448.1"/>
        </source>
    </evidence>
    <sequence length="794" mass="88527" checksum="572EAB9B51AF548C" modified="2011-11-16" version="1">MQVRVGLTLMLCAVLLSSATASSDDESNQDESIDSKSSLPADESVKDHSTTGRVVAGQVFVDSEEPEVESPLQDEEESSKTEEEVSVSEEISFVESPSLSSKSYEEAKRARKPVLTAIEGTAHGEPCHFPFLFLDKEYDECTSDGRQDGRLWCATTYDYKTDEKWGFCETEEDAAKRRQMQEAEMIYQAGMKILNGSNRKSQKREAYRYLQKAAGMNHTKALERVSYALLFGDYLTQNIQAAKEMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVVQYLLLAEQGYEVAQSNSAFILDQKEATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIREANIRDIFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPVPRPPGPRPAPPQQEGPPEQQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3HDR1</accession>
    <name>G3HDR1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Commd1</name>
        <name evidence="5" type="ORF">I79_008648</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the COMM domain-containing protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000301">
        <property type="protein sequence ID" value="EGW00368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502196.1">
        <property type="nucleotide sequence ID" value="XM_003502148.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243829.1">
        <property type="nucleotide sequence ID" value="XM_027388028.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HDR1"/>
    <dbReference type="STRING" id="10029.G3HDR1"/>
    <dbReference type="PaxDb" id="10029-XP_007612460.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009154.1">
        <property type="protein sequence ID" value="ENSCGRP00001005903.1"/>
        <property type="gene ID" value="ENSCGRG00001007842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767564"/>
    <dbReference type="KEGG" id="cge:100767564"/>
    <dbReference type="CTD" id="150684"/>
    <dbReference type="eggNOG" id="ENOG502RXN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012029"/>
    <dbReference type="OMA" id="MPTAIVE"/>
    <dbReference type="OrthoDB" id="10251426at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019871">
        <property type="term" value="F:sodium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034383">
        <property type="term" value="P:low-density lipoprotein particle clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902072">
        <property type="term" value="P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902306">
        <property type="term" value="P:negative regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048227">
        <property type="term" value="P:plasma membrane to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904109">
        <property type="term" value="P:positive regulation of cholesterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905751">
        <property type="term" value="P:positive regulation of endosome to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000010">
        <property type="term" value="P:positive regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04749">
        <property type="entry name" value="Commd1_MURR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033776">
        <property type="entry name" value="COMMD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037351">
        <property type="entry name" value="Murr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17221">
        <property type="entry name" value="COMMD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="COMM" evidence="4">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGW00368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027243829.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20936" checksum="9EE04B40DD38F43C" modified="2011-11-16" version="1">MAGELEGSKSLSGLLSGLAQDAFHGHPGITEELLHSQLYPEVPLEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITCEQAAVISKFWKSHKTRIRESLVNQSRWDNGLRGLSWRVDGKSQSRHSAQIDTPVAIIELEFGKSGQESEFLCLEFDEVKVKQTLKRLSEVEESISTLMQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3HE13</accession>
    <name>G3HE13_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Borealin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cell division cycle-associated protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Cdca8</name>
        <name evidence="15" type="ORF">I79_008782</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000307">
        <property type="protein sequence ID" value="EGW00542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502292.1">
        <property type="nucleotide sequence ID" value="XM_003502244.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255032.1">
        <property type="nucleotide sequence ID" value="XM_027399231.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HE13"/>
    <dbReference type="STRING" id="10029.G3HE13"/>
    <dbReference type="GlyGen" id="G3HE13">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007616757.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010925.1">
        <property type="protein sequence ID" value="ENSCGRP00001006934.1"/>
        <property type="gene ID" value="ENSCGRG00001009411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753031"/>
    <dbReference type="KEGG" id="cge:100753031"/>
    <dbReference type="CTD" id="55143"/>
    <dbReference type="eggNOG" id="ENOG502QS4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011115"/>
    <dbReference type="OrthoDB" id="6360905at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046466">
        <property type="entry name" value="Borealin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF6">
        <property type="entry name" value="BOREALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10512">
        <property type="entry name" value="Borealin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="13">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Borealin C-terminal" evidence="14">
        <location>
            <begin position="166"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGW00542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027255032.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31142" checksum="9C21871C4C7933F8" modified="2011-11-16" version="1">MAPKKGSSRGARANALRSRKLASFLKDFDREVQIRINQIESDRQNLLKEVENLYNIEILRLPKALREMNWLDYFALGGNKQALEEAATADVDITEINKLTAEAIQTPLKSVKKRKVVQVDEVIMEEEEEEKNPKNLRSTRVKRCPPSKKRTQSIQGRSRSKRLSHDFVTPAVSRLEPSMVKPTPGVTPRFDSRVFKTPGLRTPAAREQIYNVSINGSPLADSKEISLTVPVGGGASLRLLASDLQRFDIAQLNPETLGNIKKLSNRLAQICSSIRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3HFH2</accession>
    <name>G3HFH2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cell division cycle protein 20 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">p55CDC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22 23 24" type="primary">Cdc20</name>
        <name evidence="18" type="ORF">I79_009312</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23 24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23 24">17A/GY</strain>
            <tissue evidence="22 23 24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation. Recognizes and binds the destruction box (D box) on protein substrates. Involved in the metaphase/anaphase transition of cell cycle. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with NEUROD2. Interacts with dimeric MAD2L1 in its closed conformation form. Interacts with BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with SIRT2. Interacts with isoform 1 of NEK2. Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex. Interacts (via the N-terminal substrate-binding domain) with FBXO5. Interacts with CCNF. Interacts with USP22.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000327">
        <property type="protein sequence ID" value="EGW08123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641477.1">
        <property type="nucleotide sequence ID" value="XM_007643287.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641478.1">
        <property type="nucleotide sequence ID" value="XM_007643288.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254843.1">
        <property type="nucleotide sequence ID" value="XM_027399042.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254844.1">
        <property type="nucleotide sequence ID" value="XM_027399043.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254846.1">
        <property type="nucleotide sequence ID" value="XM_027399045.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HFH2"/>
    <dbReference type="STRING" id="10029.G3HFH2"/>
    <dbReference type="PaxDb" id="10029-XP_007617364.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017746.1">
        <property type="protein sequence ID" value="ENSCGRP00001013509.1"/>
        <property type="gene ID" value="ENSCGRG00001014621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767761"/>
    <dbReference type="KEGG" id="cge:100767761"/>
    <dbReference type="CTD" id="991"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183104"/>
    <dbReference type="OMA" id="EAGINEC"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990949">
        <property type="term" value="P:metaphase/anaphase transition of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090129">
        <property type="term" value="P:positive regulation of synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031915">
        <property type="term" value="P:positive regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040020">
        <property type="term" value="P:regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000224">
        <property type="entry name" value="cell division cycle protein 20 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF3">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 18 22" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="17">
        <location>
            <begin position="176"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGW08123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027254843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027254844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027254846.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="54723" checksum="2DF1A3CACF4B80C2" modified="2011-11-16" version="1">MAQFVFESDLHSLLKLDAPIPNAPVARWQRKAKEATGPAPSPMRAANRSHSAGRTPGRTPGKSNSKVQSTPSKPGGDRYIPHRSASQMEVASFLLSKENQPEDGETPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMEQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKRLRNMASHSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNVVNVWPSGPGESGWAPLQTFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTARVLSLTMSPDGATVASAAADETLRLWRCFELDPALRKEREKASVAKSSLIHQGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3HRQ4</accession>
    <name>G3HRQ4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myosin light polypeptide 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Myl6</name>
        <name evidence="11" type="ORF">I79_013501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory light chain of myosin. Does not bind calcium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6.</text>
    </comment>
    <dbReference type="EMBL" id="JH000638">
        <property type="protein sequence ID" value="EGW12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007644884.1">
        <property type="nucleotide sequence ID" value="XM_007646694.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248561.1">
        <property type="nucleotide sequence ID" value="XM_027392760.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HRQ4"/>
    <dbReference type="SMR" id="G3HRQ4"/>
    <dbReference type="STRING" id="10029.G3HRQ4"/>
    <dbReference type="PaxDb" id="10029-XP_007644883.1"/>
    <dbReference type="GeneID" id="100689052"/>
    <dbReference type="CTD" id="4637"/>
    <dbReference type="eggNOG" id="KOG0030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HRQ4"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000019">
        <property type="entry name" value="Myosin light chain 1 skeletal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000056">
        <property type="entry name" value="Myosin light chain 1 skeletal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF43">
        <property type="entry name" value="MYOSIN LIGHT POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="4" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027248561.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16930" checksum="A2B7B4F41179523D" modified="2011-11-16" version="1">MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3HUG5</accession>
    <name>G3HUG5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 18">Olfactory receptor 10K2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">LOC100750789</name>
        <name evidence="14" type="ORF">I79_014575</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000737">
        <property type="protein sequence ID" value="EGV98769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003507011.4"/>
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        <property type="nucleotide sequence ID" value="XM_027416934.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HUG5"/>
    <dbReference type="STRING" id="10029.G3HUG5"/>
    <dbReference type="PaxDb" id="10029-XP_007628343.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005982.1">
        <property type="protein sequence ID" value="ENSCGRP00001004039.1"/>
        <property type="gene ID" value="ENSCGRG00001005057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750789"/>
    <dbReference type="KEGG" id="cge:100750789"/>
    <dbReference type="eggNOG" id="ENOG502QSAJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9975554at2759"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 14 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGV98769.1"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004039.1"/>
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            <dbReference type="Proteomes" id="UP000001075"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027272735.1"/>
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    </evidence>
    <sequence length="314" mass="35152" checksum="6EC994B170142686" modified="2011-11-16" version="1">MECVNKTVVKEFVFLGFSTLAELQLLLFIVFLLLYLFTLSTNAVIISTIVLDRALHTPMYFFLSVLSCSETCYTFVIVPKMLVDLLARKKSISFLGCAVQMFAFLFLGCSHSFLLAAMGYDRYVAICHPLRYTVLMGHRVCVGLVAAACVCGFTVAQIITSLVFHLPFQTSNQLRHFFCDISPVLKLACHHAHFTQITIFLLCVLVLVIPLLLILASYVHIISAILQFPSTLGRYKAFSTCASHLIVVIVHYGCASFIYLRPKSGYSSSQDALISVSYTILTPLFNPVIYSLRNKEFKSALHRVIGRTVTLRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3HWJ9</accession>
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        <name evidence="7 10 11" type="primary">Fam83h</name>
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    <organism evidence="6 8">
        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10 11">17A/GY</strain>
            <tissue evidence="10 11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM83 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000832">
        <property type="protein sequence ID" value="EGV92735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003507632.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259988.1">
        <property type="nucleotide sequence ID" value="XM_027404187.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259989.1">
        <property type="nucleotide sequence ID" value="XM_027404188.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HWJ9"/>
    <dbReference type="STRING" id="10029.G3HWJ9"/>
    <dbReference type="PaxDb" id="10029-XP_007614797.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016239.1">
        <property type="protein sequence ID" value="ENSCGRP00001012006.1"/>
        <property type="gene ID" value="ENSCGRG00001013512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754245"/>
    <dbReference type="KEGG" id="cge:100754245"/>
    <dbReference type="CTD" id="286077"/>
    <dbReference type="eggNOG" id="ENOG502QW7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159342"/>
    <dbReference type="OMA" id="GCHGEDT"/>
    <dbReference type="OrthoDB" id="9832446at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990254">
        <property type="term" value="F:keratin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044380">
        <property type="term" value="P:protein localization to cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09188">
        <property type="entry name" value="PLDc_FAM83H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000004">
        <property type="entry name" value="protein FAM83H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050944">
        <property type="entry name" value="FAM83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041996">
        <property type="entry name" value="PLDc_FAM83H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012461">
        <property type="entry name" value="SACK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16181">
        <property type="entry name" value="PROTEIN FAM83A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16181:SF29">
        <property type="entry name" value="PROTEIN FAM83A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07894">
        <property type="entry name" value="SACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffolding anchor of CK1" evidence="5">
        <location>
            <begin position="14"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV92735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027259988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027259989.1"/>
        </source>
    </evidence>
    <sequence length="1165" mass="126578" checksum="647E01C0A529078F" modified="2011-11-16" version="1">MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALTEGGPEAYSRFLASEGAPDFLCPEELEHVSRHLQPPQYVAREPPEGSPPDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHLKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGMLARMDAYALAPYSGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREELQRMPGGALEPHAGLRPLARPAEAGPMGELAGPRGFFQARHLEMDAFKRHSYTAADGAGAVENFAAARQVSRQTFLSHGDDFRFQTSHFQRDQLYQQHYQWDPQFAPTRPQGLFEKLRAGRPGFADPDDLALGAGSRFPELGGDVHQRLEYVPSSASREVRHGSDPAFGTGPRGVEPNGALRPNLGQRFPCQASLRQGLDTTTEVEPERRGGPEGRAGLRHWRLASYLSGCHGDGGEEGLPMETEAYDDEVLTPGGRDLLPSAFRNPVPFPAKGPKPGSGSGGGDSSEREGTEETNLTKQDSFRSRLNPLIQRSSRLRSSLIFASQAEGASGTTATTTEKVQLLHKEQTVSETLGPSGEAVRSSASAKVAELLEKYKGPARDPGGAGGPITASHHSKAVVAQSWREEVVAPGGAGTERRSLESCLLDLRDSFAQQLHQEAERHPGAASLTAAQLLDTLGSTDRLPSRLLSTQGRSLSPQGRDSPPLEGPGTHQLPYSEPKGSPTPNYPEHKGSPTSGFPSRRGSPTTGLTEQKGSPTSAYPDRRGSPVPPVPERRGSPVPPVPERRGSLTFAGEPSKTGPTEEVTSGPMEALRKGSLRLRQFLSPKSERRGEDEGSFPAPQENGQPESPRRPSLGRGDSTEAAADERSPKVRLASATANALYSSNLRDDTKAILEQISAHGQKHRGVPAPGPSHSSPELGRPTTAGDLSPDMSDKDKCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEAGSTGAGDNLADEDTRDSKMGKFVPKILGTFKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G3HWR5</accession>
    <name>G3HWR5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100756949</name>
        <name evidence="13" type="ORF">I79_015413</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000837">
        <property type="protein sequence ID" value="EGW08426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007646468.1">
        <property type="nucleotide sequence ID" value="XM_007648278.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242305.1">
        <property type="nucleotide sequence ID" value="XM_027386504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HWR5"/>
    <dbReference type="STRING" id="10029.G3HWR5"/>
    <dbReference type="PaxDb" id="10029-XP_007614099.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018224.1">
        <property type="protein sequence ID" value="ENSCGRP00001013987.1"/>
        <property type="gene ID" value="ENSCGRG00001014981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756949"/>
    <dbReference type="KEGG" id="cge:100756949"/>
    <dbReference type="eggNOG" id="ENOG502RCGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163058"/>
    <dbReference type="OMA" id="KMLRDTW"/>
    <dbReference type="OrthoDB" id="9615015at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15940">
        <property type="entry name" value="7tmA_OR4E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="44"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW08426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027242305.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35452" checksum="AE113019772FB938" modified="2011-11-16" version="1">MDKAVLANQTSVMSFRLRGLSVNPKIQMAVFFMFLIFYVLTLIGNILIVITIIYDRRLHTPMYFFLSNLSFIDVCHSTVTVPKMLRDTLSEEKLIPFDACVVQMFFLHLFACTEIFLLTVMAYDRYVAICKPLQYMTVMNWKVCMLLAGALWTGGTIHSISLTSLTINLPYCGPDEIDNFFCDVPQVIKLACTDTRIIEILIVSNSGLISVVCFVVLVVSYAVILVSLRQQISEGKRKALSTCAAHLTVVTLFLGHCIFIYSRPSTSLPEDKVVSVFFTAVTPLLNPIIYTLRNEDMKNALNKLIRRKEIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3HXL1</accession>
    <name>G3HXL1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 13">Poly(rC)-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Pcbp1</name>
        <name evidence="9" type="ORF">I79_015737</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027428603.2"/>
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    <dbReference type="SMR" id="G3HXL1"/>
    <dbReference type="STRING" id="10029.G3HXL1"/>
    <dbReference type="PaxDb" id="10029-XP_007607497.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018327.1">
        <property type="protein sequence ID" value="ENSCGRP00001014090.1"/>
        <property type="gene ID" value="ENSCGRG00001015078.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000161582"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
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    </dbReference>
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        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
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        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
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    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
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    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="278"/>
            <end position="348"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="SMART" id="SM00322"/>
        </source>
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            <dbReference type="EMBL" id="EGW06913.1"/>
        </source>
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    </evidence>
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        <name evidence="9" type="ORF">I79_015756</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH000883">
        <property type="protein sequence ID" value="EGW12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003508027.1">
        <property type="nucleotide sequence ID" value="XM_003507979.4"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027415761.2"/>
    </dbReference>
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    <dbReference type="SMR" id="G3HXM8"/>
    <dbReference type="STRING" id="10029.G3HXM8"/>
    <dbReference type="PaxDb" id="10029-XP_007634757.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014011.1">
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        <property type="gene ID" value="ENSCGRG00001011829.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751181"/>
    <dbReference type="KEGG" id="cge:100751181"/>
    <dbReference type="CTD" id="23562"/>
    <dbReference type="eggNOG" id="ENOG502QR8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161312"/>
    <dbReference type="OMA" id="PTAYKDN"/>
    <dbReference type="OrthoDB" id="8749238at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01385">
        <property type="entry name" value="CLAUDIN14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027271562.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25559" checksum="2D4F29C5F5A456C3" modified="2011-11-16" version="1">MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSLLALPRDLQAARALMVISCLLSGTASACAVVGMKCTRCAKGTPAKTTFAVLGGALFLLAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYQAQSRAGATTTAAAPAYRPPAAYKDNRAPSVTSASHSGYRLNDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3HXX1</accession>
    <name>G3HXX1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">Hus1</name>
        <name evidence="11" type="ORF">H671_1g1461</name>
        <name evidence="10" type="ORF">I79_015887</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. HUS1 interacts with POLB, HDAC1, FEN1, PCNA and RAD9B. HUS1 does not interact with RAD17. Interacts with DNAJC7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000896">
        <property type="protein sequence ID" value="EGW04888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE663858">
        <property type="protein sequence ID" value="ERE90724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007646881.1">
        <property type="nucleotide sequence ID" value="XM_007648691.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243929.1">
        <property type="nucleotide sequence ID" value="XM_027388128.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HXX1"/>
    <dbReference type="STRING" id="10029.G3HXX1"/>
    <dbReference type="PaxDb" id="10029-XP_007637839.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020544.1">
        <property type="protein sequence ID" value="ENSCGRP00001016300.1"/>
        <property type="gene ID" value="ENSCGRG00001016677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754140"/>
    <dbReference type="KEGG" id="cge:100754140"/>
    <dbReference type="CTD" id="3364"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000706"/>
    <dbReference type="OMA" id="VCWMRLE"/>
    <dbReference type="OrthoDB" id="10063861at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000006">
        <property type="entry name" value="Checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF4">
        <property type="entry name" value="CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGW04888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ERE90724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027243929.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31486" checksum="9ED7CFD62A6B0F4F" modified="2011-11-16" version="1">MKFRAKIVDLACLNHFTRVSNMIAKLAKTCTLRISPEKLNFILSDKLASGGVSMWCELEQENIFSEFQMEGVSAENNAIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELQLSSSSSSRIVTHDIPIKVIPRRLWKDLQEPSVPDSDVSIYLPALKTMKSVVEKMKNISNHLVIEANLNGELNLKIETELVCVTTHFKDLGNPLLSSESASQSRHPEDMAEVHIDIKKLLQFLAGQQVTPTKAVCNIVSNRIVHFDLLLEDISLQYFIPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3I0I2</accession>
    <name>G3I0I2_CRIGR</name>
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        <submittedName>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">LOC100763520</name>
        <name evidence="9" type="ORF">I79_016867</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha/beta interferon family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001015">
        <property type="protein sequence ID" value="EGV95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027400519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I0I2"/>
    <dbReference type="STRING" id="10029.G3I0I2"/>
    <dbReference type="PaxDb" id="10029-XP_007616866.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007347.1">
        <property type="protein sequence ID" value="ENSCGRP00001004848.1"/>
        <property type="gene ID" value="ENSCGRG00001006253.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100763520"/>
    <dbReference type="eggNOG" id="ENOG502TDM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVEATCC"/>
    <dbReference type="OrthoDB" id="9620590at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Interferon_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691:SF37">
        <property type="entry name" value="INTERFERON OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691">
        <property type="entry name" value="TYPE I INTERFERON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 7" id="KW-0202">Cytokine</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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    <feature type="chain" id="PRO_5044732293" evidence="8">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027256320.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21881" checksum="8CA8F68CFDFFAA34" modified="2011-11-16" version="1">MLPVLPLLLGLTLGCSKDCSLDRGAFWSMHSQRIEALGFLRKLKIMPVVPCLQDRNDFRCPWKKGPVTQGMQRVEATCCLSEMLGQVLHLFATEASRRAWPETMLRQLLNSLFYALEALEGTGERRLSCPPTFVLAIRTYFSRISGYLEGKRFSPCSWEIVRAEMQVALATLPVPPERSPKKRRIAMPESPLQ</sequence>
</entry>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14 15">17A/GY</strain>
            <tissue evidence="13 14 15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001318">
        <property type="protein sequence ID" value="EGW05720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510562.1">
        <property type="nucleotide sequence ID" value="XM_003510514.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267792.1">
        <property type="nucleotide sequence ID" value="XM_027411991.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299520.1">
        <property type="nucleotide sequence ID" value="XM_035443629.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299521.1">
        <property type="nucleotide sequence ID" value="XM_035443630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299522.1">
        <property type="nucleotide sequence ID" value="XM_035443631.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317124.1">
        <property type="nucleotide sequence ID" value="XM_035461233.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317125.1">
        <property type="nucleotide sequence ID" value="XM_035461234.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317126.1">
        <property type="nucleotide sequence ID" value="XM_035461235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I5S6"/>
    <dbReference type="STRING" id="10029.G3I5S6"/>
    <dbReference type="PaxDb" id="10029-XP_007618921.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031684.1">
        <property type="protein sequence ID" value="ENSCGRP00001027437.1"/>
        <property type="gene ID" value="ENSCGRG00001024448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758681"/>
    <dbReference type="KEGG" id="cge:100758681"/>
    <dbReference type="CTD" id="56912"/>
    <dbReference type="eggNOG" id="ENOG502QPNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QYIRRYT"/>
    <dbReference type="OrthoDB" id="2119217at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW05720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027267792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035299520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035299521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035299522.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34158" checksum="9F6A7C06AD8305A4" modified="2011-11-16" version="1">MADNSSDEYEEENNKEKKKPSQLTPQRGFSENDDDDDDDSSETDSDDDDDDEEHGAPLEGAYDPADYEHLPVSAEIKELFEYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVPRPDGKPDHLGLLVLDEPSTKQSDPTVLSLWLTENSKQHNITQHMKVKSLEDAEKNPKAIDTWIESISELHRSKPPATVHYTRPMPDIDTLMQEWSPEFEELLGKVSLPTVEIDCSLADYIDMICAILDIPFYKSRIQSLHLLFSLYSEFKNSQHFKALAEGKKAFTPPSNSASQAGDAETLTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3I702</accession>
    <name>G3I702_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lipoyl amidotransferase LIPT1, mitochondrial</fullName>
            <ecNumber evidence="12">2.3.1.200</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipoate biosynthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Lipoate-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Lipoyl ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Lipoyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Lipt1</name>
        <name evidence="19" type="ORF">I79_019283</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2. In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20473"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:83091"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]</text>
            <dbReference type="Rhea" id="RHEA:16413"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="EC" id="2.3.1.200"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16414"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.200" evidence="12"/>
    <dbReference type="EMBL" id="JH001401">
        <property type="protein sequence ID" value="EGW10904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510916.1">
        <property type="nucleotide sequence ID" value="XM_003510868.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242621.1">
        <property type="nucleotide sequence ID" value="XM_027386820.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I702"/>
    <dbReference type="STRING" id="10029.G3I702"/>
    <dbReference type="GlyGen" id="G3I702">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007612014.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002685.1">
        <property type="protein sequence ID" value="ENSCGRP00001002121.1"/>
        <property type="gene ID" value="ENSCGRG00001002192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763903"/>
    <dbReference type="KEGG" id="cge:100763903"/>
    <dbReference type="CTD" id="51601"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008846"/>
    <dbReference type="OMA" id="RYQNWDW"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000005">
        <property type="entry name" value="Lipoyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000045">
        <property type="entry name" value="lipoyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="18">
        <location>
            <begin position="57"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGW10904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027242621.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42431" checksum="EDE2E6760228480D" modified="2011-11-16" version="1">MLIPFSMKNCFRLLCHHKVPTASFRNPATHGLILQSISNDVYQNLALEDWIHDHIHLEGMPILFLWRNSPCVVIGRHQNPWQECNLHLMRQEGIKLARRRSGGGTVYHDLGNINLTFFTTKTKYDRMENLKLIVRALNAVQPYLDVQPTKKFDLLLDGQYKISGTASKIGRIAAYHHCTLLCSADRTALSSLLKSPYQGIKSNATPSVPSVIKNLLEKDPLLSCEVLMSAIAAEYAACHQIDNHIKLINPADETQFPGINSKAKELQSWQWIYGRTPKFSVNTTFRVPYEQAHLEIQVFMDVKNGLIETCDIKAPDHWLPLEIVNKLNSGFIGSKFCPIETTLLTNILLRTCPDEQHLHSKWNILCEKIRGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3I776</accession>
    <name>G3I776_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11 12" type="primary">Rrad</name>
        <name evidence="7" type="ORF">I79_019361</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11 12">17A/GY</strain>
            <tissue evidence="11 12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Interacts with Calmodulin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001411">
        <property type="protein sequence ID" value="EGW11239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510982.1">
        <property type="nucleotide sequence ID" value="XM_003510934.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016835415.1">
        <property type="nucleotide sequence ID" value="XM_016979926.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261554.1">
        <property type="nucleotide sequence ID" value="XM_027405753.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261556.1">
        <property type="nucleotide sequence ID" value="XM_027405755.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I776"/>
    <dbReference type="STRING" id="10029.G3I776"/>
    <dbReference type="PaxDb" id="10029-XP_007626381.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024281.1">
        <property type="protein sequence ID" value="ENSCGRP00001020037.1"/>
        <property type="gene ID" value="ENSCGRG00001019311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760818"/>
    <dbReference type="KEGG" id="cge:100760818"/>
    <dbReference type="CTD" id="6236"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159836"/>
    <dbReference type="OMA" id="MKAKSCH"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04148">
        <property type="entry name" value="RGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000311">
        <property type="entry name" value="GTP-binding protein RAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017358">
        <property type="entry name" value="RGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN RAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038017">
        <property type="entry name" value="GTP-binding_GEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGW11239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027261554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027261556.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33123" checksum="641E0665056A87A5" modified="2011-11-16" version="1">MTLNGGNGGSRGAGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALAPGSLAATTAGTRTQGQRLDWPEGSSDSLSSGGSSSEEGVYKVLLLGAPGVGKSALARIFGGIEDGPDAEAAGHTYDRSITVDGEEASLMVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQTDNVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-11-09" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q9JIG1</accession>
    <name>FUT9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9</fullName>
            <ecNumber evidence="3">2.4.1.152</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fucosyltransferase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Fucosyltransferase IX</fullName>
            <shortName evidence="5">Fuc-TIX</shortName>
            <shortName>FucT-IX</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Galactoside 3-L-fucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FUT9</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Arch. Biochem. Biophys." volume="375" first="322" last="332">
            <title>Alpha(1,3)fucosyltransferases expressed by the gain-of-function Chinese hamster ovary glycosylation mutants LEC12, LEC29, and LEC30.</title>
            <authorList>
                <person name="Patnaik S.K."/>
                <person name="Zhang A."/>
                <person name="Shi S."/>
                <person name="Stanley P."/>
            </authorList>
            <dbReference type="PubMed" id="10700388"/>
            <dbReference type="DOI" id="10.1006/abbi.1999.1693"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference key="2">
        <citation type="submission" date="2004-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Patnaik S.K."/>
                <person name="Potvin B."/>
                <person name="Stanley P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes alpha(1-&gt;3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation (By similarity). Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity). Can also modify milk oligosaccharides in particular type 2 tetrasaccharide LNnT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1-&gt;4)-[alpha-L-fucosyl-(1-&gt;3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14257"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:137941"/>
            <dbReference type="EC" id="2.4.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:14258"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68044"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:145343"/>
            <dbReference type="ChEBI" id="CHEBI:176900"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:68045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-N-glycoloylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-[alpha-L-fucosyl-(1-&gt;3)]-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:90383"/>
            <dbReference type="ChEBI" id="CHEBI:90384"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:90380"/>
            <dbReference type="ChEBI" id="CHEBI:90381"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:90376"/>
            <dbReference type="ChEBI" id="CHEBI:90379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56076"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:136545"/>
            <dbReference type="ChEBI" id="CHEBI:139509"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:56077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-D-Glc + GDP-beta-L-fucose = beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-D-Glc + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:60239"/>
            <dbReference type="ChEBI" id="CHEBI:61352"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:77188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77191"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133510"/>
            <dbReference type="ChEBI" id="CHEBI:195560"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:77192"/>
        </physiologicalReaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Activated by Mn2+.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The donor-binding domain adopts a Rossman-like fold involved in GDP-beta-L-fucose sugar donor interactions.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The acceptor-binding domain adopts a Rossman-like fold consisting of six-stranded parallel beta sheets characteristic of the Toll/interleukin-1 receptor (TIR) fold family. Interacts with the LacNAc unit of type 2 LacNAc and H-type 2 LacNAc structures. It contains the catalytic base Glu-137 which deprotonates the hydroxyl group of GlcNAc while forming bridging interactions with the donor sugar to position the catalytic machinery in the active site.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">N-glycosylated with complex-type N-glycans.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.152" evidence="3"/>
    <dbReference type="EMBL" id="AF230460">
        <property type="protein sequence ID" value="AAF82412.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY628212">
        <property type="protein sequence ID" value="AAT47342.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY628213">
        <property type="protein sequence ID" value="AAT47343.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001230953.1">
        <property type="nucleotide sequence ID" value="NM_001244024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9JIG1"/>
    <dbReference type="SMR" id="Q9JIG1"/>
    <dbReference type="CAZy" id="GT10">
        <property type="family name" value="Glycosyltransferase Family 10"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q9JIG1">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-NP_001230953.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008589">
        <property type="protein sequence ID" value="ENSCGRP00001005567"/>
        <property type="gene ID" value="ENSCGRG00001007342"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00015048513">
        <property type="protein sequence ID" value="ENSCGRP00015059946"/>
        <property type="gene ID" value="ENSCGRG00015040511"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00015057520">
        <property type="protein sequence ID" value="ENSCGRP00015058682"/>
        <property type="gene ID" value="ENSCGRG00015040511"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00015061261">
        <property type="protein sequence ID" value="ENSCGRP00015039795"/>
        <property type="gene ID" value="ENSCGRG00015040511"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00015066843">
        <property type="protein sequence ID" value="ENSCGRP00015047675"/>
        <property type="gene ID" value="ENSCGRG00015040511"/>
    </dbReference>
    <dbReference type="GeneID" id="100689036"/>
    <dbReference type="KEGG" id="cge:100689036"/>
    <dbReference type="CTD" id="10690"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155095"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017083">
        <property type="term" value="F:4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106402">
        <property type="term" value="P:Lewis x epitope biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036445">
        <property type="term" value="P:neuronal stem cell division"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903236">
        <property type="term" value="P:regulation of leukocyte tethering or rolling"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000001">
        <property type="entry name" value="alpha-(1,3)-fucosyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF10">
        <property type="entry name" value="4-GALACTOSYL-N-ACETYLGLUCOSAMINIDE 3-ALPHA-L-FUCOSYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000221117" description="4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acceptor-binding" evidence="3">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Donor-binding" evidence="3">
        <location>
            <begin position="169"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acceptor-binding" evidence="3">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>GDP-beta-L-fucose</name>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3 4">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="82"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="91"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="190"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O88819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q6P4F1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9Y231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="10700388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="359" mass="42071" checksum="9D5CD8BFF07EA902" modified="2000-10-01" version="1">MTSTSKGILRPFLIVCVILACFMACLLIYIKPTNSWVFSPMESASSVLKMKNFFSTKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNEKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V5QSN9</accession>
    <name>V5QSN9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Adenylosuccinate synthetase isozyme 2</fullName>
            <shortName evidence="13">AMPSase 2</shortName>
            <shortName evidence="13">AdSS 2</shortName>
            <ecNumber evidence="13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Adenylosuccinate synthetase, acidic isozyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Adenylosuccinate synthetase, liver isozyme</fullName>
            <shortName evidence="13">L-type adenylosuccinate synthetase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">IMP--aspartate ligase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">ADSS</name>
        <name evidence="20" type="synonym">Adss</name>
        <name evidence="13" type="synonym">ADSS2</name>
        <name evidence="18 20" type="synonym">Adss2</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
            <authorList>
                <person name="Becker J."/>
                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
            </authorList>
            <dbReference type="PubMed" id="21945585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-08" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization of ADSS and ADSSL1 genes in CHO K1 cells, and genetic analysis of AdeH and AdeHG mutants of adenine biosynthesis.</title>
            <authorList>
                <person name="Vacano G.N."/>
                <person name="Patterson D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="17">Ovary</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 15">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 15">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="13"/>
    <dbReference type="EMBL" id="KF574260">
        <property type="protein sequence ID" value="AHB20190.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001278988.1">
        <property type="nucleotide sequence ID" value="NM_001292059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V5QSN9"/>
    <dbReference type="SMR" id="V5QSN9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008509.1">
        <property type="protein sequence ID" value="ENSCGRP00001005521.1"/>
        <property type="gene ID" value="ENSCGRG00001007265.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767083"/>
    <dbReference type="KEGG" id="cge:100767083"/>
    <dbReference type="CTD" id="159"/>
    <dbReference type="GeneTree" id="ENSGT00390000015553"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03127">
        <property type="entry name" value="Adenylosucc_synth_vert_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027529">
        <property type="entry name" value="AdSS_2_vert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF13">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE ISOZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="39"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="65"/>
            <end position="68"/>
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            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
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            <begin position="67"/>
            <end position="69"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
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        <location>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="162"/>
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        <ligand>
            <name>IMP</name>
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        </ligand>
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        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
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        <location>
            <begin position="330"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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            <end position="364"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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            <end position="447"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000520"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="AHB20190.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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            <dbReference type="RefSeq" id="NP_001278988.1"/>
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    <sequence length="456" mass="50035" checksum="9902899FB8EA405A" modified="2014-02-19" version="1">MSISESNPAAASLPNGDCGRPRAPPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLDGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMERIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHFPANQEVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HTB7</accession>
    <name>A0A061HTB7_CRIGR</name>
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        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
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        <name evidence="12 15 16 17 18" type="primary">LOC113837383</name>
        <name evidence="11" type="ORF">H671_21719</name>
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    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
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    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16 17">17A/GY</strain>
            <tissue evidence="15 16 17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KE691368">
        <property type="protein sequence ID" value="ERE43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287134.1">
        <property type="nucleotide sequence ID" value="XM_027431333.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287136.1">
        <property type="nucleotide sequence ID" value="XM_027431335.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287137.1">
        <property type="nucleotide sequence ID" value="XM_027431336.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305314.1">
        <property type="nucleotide sequence ID" value="XM_035449423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HTB7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023832.1">
        <property type="protein sequence ID" value="ENSCGRP00001019588.1"/>
        <property type="gene ID" value="ENSCGRG00001018981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113837383"/>
    <dbReference type="KEGG" id="cge:113837383"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043584">
        <property type="term" value="P:nose development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
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        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ERE43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027287134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027287136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027287137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035305314.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7825" checksum="153206A93A2CBA40" modified="2014-09-03" version="1">MSNNMAKIAEARKTVEQLKLEVNIDRIKVSQAAAELLAFCETHAKDDPLVTPVPAAENPFRDKRLFCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HZ21</accession>
    <name>A0A061HZ21_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="12">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Dus4l</name>
        <name evidence="16" type="ORF">H671_5g14797</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = uridine(20a) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:53350"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = uridine(20a) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5,6-dihydrouridine(20b) in tRNA + NAD(+) = uridine(20b) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53352"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:53354"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5,6-dihydrouridine(20b) in tRNA + NADP(+) = uridine(20b) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53356"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:53358"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Dus family. Dus4 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KE680281">
        <property type="protein sequence ID" value="ERE72718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511158.1">
        <property type="nucleotide sequence ID" value="XM_003511110.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272801.1">
        <property type="nucleotide sequence ID" value="XM_027417000.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HZ21"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017127.1">
        <property type="protein sequence ID" value="ENSCGRP00001012892.1"/>
        <property type="gene ID" value="ENSCGRG00001014181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754261"/>
    <dbReference type="KEGG" id="cge:100754261"/>
    <dbReference type="CTD" id="11062"/>
    <dbReference type="OMA" id="QRPHHDI"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102266">
        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000100">
        <property type="entry name" value="tRNA-dihydrouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 12 14" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ERE72718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027272801.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35848" checksum="E1D6B547482358A5" modified="2014-09-03" version="1">MRSDSIPITICQERKKDPMEMFQSGQMVKICAPMVRYSKLAFRTLVRKYSCDLCYTPMIVAADFVRSIKARDSEFTTNQGDCPLIVQFAANDARILSDAAQIVCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQDMVKQVRNQVENPRFSVSIKIRIHDDLTRTIDLCQKAEATGVSWITVHGRTIEERHQPVHYEAIKIIKESVSIPVVANGDIRNLKEAENVWQMSGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVDIALELGTPFMCFHQHLMYMMEKITSRQEKRVFNALSSTSAVLEYLTDNYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HZD8</accession>
    <name>A0A061HZD8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="1 5">HAUS augmin-like complex subunit 7</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">HAUS augmin-like complex, subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">Haus7</name>
        <name evidence="1" type="ORF">H671_xg20649</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
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                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">17A/GY</strain>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <strain evidence="4">17A/GY</strain>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="KE685970">
        <property type="protein sequence ID" value="ERE63790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="ERE63790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013004.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027288229.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41031" checksum="D7258154D94E906A" modified="2014-09-03" version="1">MAEKGAATVVGGDSGDSYYEDVCDDRVVKAAVEVFEKLKGVKCPFLDGLYITEPKTILELLCRPSKYRLDILEWMCIWVCPSLQDKFSSLKGTAVDVKIQEMVKLGHDLMLCTPDDQDLLMGRECPQKQLQFMDQLLDMMRSLATGCSTSSSLKEHLEDTTEKNEALLGELLSSPNLWAILKPENEPWPLDMQSSLNKQCDDLPKAGPSAQSEGEKVADLARQLQESATKLQTLRDQCFAQHKAGTDTSTIDQKLRLVISDFYQLILAFLQVYDDELGKCCQRPLPSLHPSGPIIQAVYQTLTSCGQLLRAVMEIADTSAEAMEAARRQQGEPNCWGSNNSGISLATRIDEVTQKYKILTDTLHRETR</sequence>
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    <name>A0A061I259_CRIGR</name>
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        <submittedName>
            <fullName evidence="12">C-type lectin domain family 9 member A isoform X1</fullName>
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        <submittedName>
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        <submittedName>
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        <name evidence="9 12" type="primary">Clec9a</name>
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    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE682674">
        <property type="protein sequence ID" value="ERE66436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003509298.1">
        <property type="nucleotide sequence ID" value="XM_003509250.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285625.1">
        <property type="nucleotide sequence ID" value="XM_027429824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I259"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011643.1">
        <property type="protein sequence ID" value="ENSCGRP00001007589.1"/>
        <property type="gene ID" value="ENSCGRG00001009980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770747"/>
    <dbReference type="KEGG" id="cge:100770747"/>
    <dbReference type="CTD" id="283420"/>
    <dbReference type="GeneTree" id="ENSGT00940000161796"/>
    <dbReference type="OMA" id="WDSPAPN"/>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
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        <property type="entry name" value="CLEC9A"/>
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        <property type="entry name" value="CTDL_fold"/>
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        <property type="entry name" value="NKR-like_CTLD"/>
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        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 9 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47727:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 9 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="120"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ERE66436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027285625.1"/>
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        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
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                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
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                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
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                <person name="Goesmann A."/>
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                <person name="Mott J.E."/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
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                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
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        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
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                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
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    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73008"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:40816"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="12"/>
    <dbReference type="EMBL" id="KE668298">
        <property type="protein sequence ID" value="ERE84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506943.1">
        <property type="nucleotide sequence ID" value="XM_003506895.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254798.1">
        <property type="nucleotide sequence ID" value="XM_027398997.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IDH0"/>
    <dbReference type="SMR" id="A0A061IDH0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028547.1">
        <property type="protein sequence ID" value="ENSCGRP00001024301.1"/>
        <property type="gene ID" value="ENSCGRG00001022269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753835"/>
    <dbReference type="KEGG" id="cge:100753835"/>
    <dbReference type="CTD" id="30814"/>
    <dbReference type="OMA" id="IGGSHWP"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034374">
        <property type="term" value="P:low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046471">
        <property type="term" value="P:phosphatidylglycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000001">
        <property type="entry name" value="Basic phospholipase A2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF56">
        <property type="entry name" value="GROUP IIE SECRETORY PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044513394" description="Phospholipase A2" evidence="12">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="13">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="61"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027254798.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IQ68</accession>
    <name>A0A061IQ68_CRIGR</name>
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        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="15">Tropomyosin alpha-4 chain isoform X1</fullName>
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    </protein>
    <gene>
        <name evidence="15" type="primary">Tpm4</name>
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    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE664018">
        <property type="protein sequence ID" value="ERE90441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003499135.3">
        <property type="nucleotide sequence ID" value="XM_003499087.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250708.1">
        <property type="nucleotide sequence ID" value="XM_027394907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IQ68"/>
    <dbReference type="GeneID" id="100761146"/>
    <dbReference type="KEGG" id="cge:100761146"/>
    <dbReference type="CTD" id="7171"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="RefSeq" id="XP_027250708.1"/>
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    </evidence>
    <sequence length="284" mass="32779" checksum="A61422F0175B8F59" modified="2014-09-03" version="1">MEAIKKKMQMLKLDKENAIDRAEQAEVDKKAAEDKCKQVEEELTHLQKKLKGTEDELDRHSEDLKEAQEKLELAEKKALDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7GQY5</accession>
    <name>A0A3L7GQY5_CRIGR</name>
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        <submittedName>
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        </submittedName>
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    <gene>
        <name evidence="13 16" type="primary">Ltb4r2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF8">
        <property type="entry name" value="LEUKOTRIENE B4 RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01478">
        <property type="entry name" value="LTB2RECEPTOR"/>
    </dbReference>
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        <property type="entry name" value="LTBRECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="288"/>
        </location>
    </feature>
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        <location>
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            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027245861.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="37923" checksum="C330553542F70350" modified="2019-02-13" version="1">MSVCYRPPGNETLLSWKASRATGTAFLLLAALLGLPGNCFVVWSLAGWRPTAGRPLAATLVLHLALADGAVLLLTPLFVAFLSGQAWPLGQVGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLGVWLAALVLAVPAAVYRHLWGDRVCQLCHPSALHAAAHLSLETLTAFVLPFGTVLSCYGVTLARLRGARWGSGRHGTRVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGPLARLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGETRGGSRSREGTMELRTTPRLKVVGQGRGNGDPGGGERMEKNSQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H5L6</accession>
    <name>A0A3L7H5L6_CRIGR</name>
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        <recommendedName>
            <fullName evidence="8">B9 domain-containing protein 2</fullName>
        </recommendedName>
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    <gene>
        <name evidence="9 12" type="primary">B9d2</name>
    </gene>
    <organism evidence="9 10">
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027239924.2">
        <property type="nucleotide sequence ID" value="XM_027384123.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286180.1">
        <property type="nucleotide sequence ID" value="XM_027430379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H5L6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012786.1">
        <property type="protein sequence ID" value="ENSCGRP00001008655.1"/>
        <property type="gene ID" value="ENSCGRG00001010904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103160326"/>
    <dbReference type="KEGG" id="cge:103160326"/>
    <dbReference type="CTD" id="80776"/>
    <dbReference type="OrthoDB" id="184109at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF2">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027286180.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19264" checksum="790E5EB1313345E0" modified="2019-02-13" version="1">MAEVHVIGQILGATGFSESSLFCKWGIHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHLQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLDCPTWRPLGSWREQLARAFVGGGPQLLHADTIYSGADRYRLHTAAGGTVHLAIGLLLRHFDRYGVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HCV9</accession>
    <name>A0A3L7HCV9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAP four-disulfide core domain 15B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">WAP four-disulfide core domain protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Wfdc12</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003504640.1">
        <property type="nucleotide sequence ID" value="XM_003504592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279054.1">
        <property type="nucleotide sequence ID" value="XM_027423253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HCV9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016533.1">
        <property type="protein sequence ID" value="ENSCGRP00001012300.1"/>
        <property type="gene ID" value="ENSCGRG00001013744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763499"/>
    <dbReference type="KEGG" id="cge:100763499"/>
    <dbReference type="CTD" id="128488"/>
    <dbReference type="GeneTree" id="ENSGT00390000002529"/>
    <dbReference type="OMA" id="AKKCCFY"/>
    <dbReference type="OrthoDB" id="9794641at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594370" evidence="1">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027279054.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9299" checksum="7AF208C67C45A65B" modified="2019-02-13" version="1">MKPLSLSLLTVTILLCCDMTQPTFRKGMSVDKPGYCPEFHLSCPFTLLPICWRDRSCRGAKKCCFFYCQMRCVEPWHTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HS96</accession>
    <name>A0A3L7HS96_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Claudin domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Claudin-25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18 19 20" type="primary">Cldnd1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19 20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19 20">17A/GY</strain>
            <tissue evidence="18 19 20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in negatively regulating the permeability of cells to small molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMP-22/EMP/MP20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003509937.1">
        <property type="nucleotide sequence ID" value="XM_003509889.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268252.1">
        <property type="nucleotide sequence ID" value="XM_027412451.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300334.1">
        <property type="nucleotide sequence ID" value="XM_035444443.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300336.1">
        <property type="nucleotide sequence ID" value="XM_035444445.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316659.1">
        <property type="nucleotide sequence ID" value="XM_035460768.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316661.1">
        <property type="nucleotide sequence ID" value="XM_035460770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HS96"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030083.1">
        <property type="protein sequence ID" value="ENSCGRP00001025837.1"/>
        <property type="gene ID" value="ENSCGRG00001023323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770002"/>
    <dbReference type="KEGG" id="cge:100770002"/>
    <dbReference type="CTD" id="56650"/>
    <dbReference type="OMA" id="NKSIWED"/>
    <dbReference type="OrthoDB" id="9885915at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000009">
        <property type="entry name" value="Claudin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042356">
        <property type="entry name" value="CLDN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14347">
        <property type="entry name" value="CLAUDIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14347:SF3">
        <property type="entry name" value="CLAUDIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027268252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035300334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035300336.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28502" checksum="08CA6AC31A27BC1B" modified="2019-02-13" version="1">MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDSNKVAWDDFLGDEADEKTYNDALFRYNGTMGLWRRCITIPKNTYWYTPPERTESFDVVTKCMSFSLNEQFMEKYVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLVCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLGLPENVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IG90</accession>
    <name>A0A3L7IG90_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Translocator protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Tspo2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035292380.1">
        <property type="nucleotide sequence ID" value="XM_035436489.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306906.1">
        <property type="nucleotide sequence ID" value="XM_035451015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IG90"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012951.1">
        <property type="protein sequence ID" value="ENSCGRP00001008804.1"/>
        <property type="gene ID" value="ENSCGRG00001011008.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756965"/>
    <dbReference type="KEGG" id="cge:100756965"/>
    <dbReference type="CTD" id="222642"/>
    <dbReference type="GeneTree" id="ENSGT00390000012980"/>
    <dbReference type="OMA" id="RDSLCPE"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140485">
        <property type="term" value="F:5-aminolevulinic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140484">
        <property type="term" value="P:5-aminolevulinic acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043353">
        <property type="term" value="P:enucleate erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF4">
        <property type="entry name" value="TRANSLOCATOR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035306906.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18365" checksum="D291D1FA447B4D68" modified="2019-02-13" version="1">MKLQGPVFVGVPLLGPILICMFTHNQTTSWCEDERKLWCPPHKVILLVWATIYSVIGYASYLVWKDLGGGFRWPLALPLGLYTLQLTLSWTFLMLFLTANNPGLALLDLLLLYGLVASMVLIWQPINKLAALLLLPYLAWLTVTTAITYRLWRDSLCPAYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LAZ4</accession>
    <name>A0A8C2LAZ4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Lsm7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Interacts with TACC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007641420.1">
        <property type="nucleotide sequence ID" value="XM_007643230.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275104.1">
        <property type="nucleotide sequence ID" value="XM_027419303.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LAZ4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001075.1">
        <property type="protein sequence ID" value="ENSCGRP00001001051.1"/>
        <property type="gene ID" value="ENSCGRG00001000807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772252"/>
    <dbReference type="CTD" id="51690"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000025">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027275104.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11588" checksum="7429DC0FB37759C8" modified="2022-01-19" version="1">MADKEKKKKESILDLSKYIDKTIRVKFQGGREASGILKGFDPLLNLVLDGTIEYMRDPDDQYKLTEDTRQLGLVVCRGTSVVLICPQDGMEAIPNPFVQQQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LCG2</accession>
    <name>A0A8C2LCG2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL16m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Mrpl16</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016819046.1">
        <property type="nucleotide sequence ID" value="XM_016963557.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262449.1">
        <property type="nucleotide sequence ID" value="XM_027406648.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LCG2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001043.1">
        <property type="protein sequence ID" value="ENSCGRP00001001019.1"/>
        <property type="gene ID" value="ENSCGRG00001000785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756893"/>
    <dbReference type="KEGG" id="cge:100756893"/>
    <dbReference type="CTD" id="54948"/>
    <dbReference type="GeneTree" id="ENSGT00390000002038"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027262449.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28568" checksum="88B3DAD2CB39412E" modified="2022-01-19" version="1">MWRLLTRTPAPLLRVHVSDSWAALPTSAGLKTLLPVPSFEDISIPERSKLKFVERVPLVPKVRREPKNLKDIRGPSTEATEFTEGNFAVLALGGGYLHWGHFEMMRLTINRSMDPKNMFAKWRVPAPFKPVTRKGVGQRMGGGKGAIDHYVTPVKTGTLIVELGGRCEFKEVQGFLDLVAHKLPFPAKAVSRETLEKMRQNQKERENNNQNPWTFERIATANMLGIRKFLSPYDLTQKGQYWGKFFLPKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LSF1</accession>
    <name>A0A8C2LSF1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Keratin-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">LOC100755805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with hair keratins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the PMG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003495593.1">
        <property type="nucleotide sequence ID" value="XM_003495545.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271559.1">
        <property type="nucleotide sequence ID" value="XM_027415758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LSF1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010743.1">
        <property type="protein sequence ID" value="ENSCGRP00001006806.1"/>
        <property type="gene ID" value="ENSCGRG00001009257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755805"/>
    <dbReference type="KEGG" id="cge:100755805"/>
    <dbReference type="GeneTree" id="ENSGT00730000111463"/>
    <dbReference type="OMA" id="CQPVGGI"/>
    <dbReference type="OrthoDB" id="9444590at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007659">
        <property type="entry name" value="Keratin_matx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007951">
        <property type="entry name" value="KRTAP_PMG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23260">
        <property type="entry name" value="KERATIN ASSOCIATED PROTEIN 3-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23260:SF9">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 11-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05287">
        <property type="entry name" value="PMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0416">Keratin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027271559.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18043" checksum="50022D9AB8531E34" modified="2022-01-19" version="1">MSFNCSTRNCSSRPVGGRYTVPAGPVTTASARDADCLSGIYLPSSFQTGSWLLDHCQESCCEPTVCQPTCYQRTSCISTPVQVTCNRQTTCVSNPCSTPCSRPLTFVSSGCQSLGGISSSCQPVGGISTTCQPVGGISTVCQPVGGISTVCQPTCGVTRTYQQSCVSSCRRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LVC8</accession>
    <name>A0A8C2LVC8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LZIC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Leucine zipper and CTNNBIP1 domain-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucine zipper and ICAT homologous domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12 13" type="primary">Lzic</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13">17A/GY</strain>
            <tissue evidence="12 13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Does not interact with CTNNB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTNNBIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511927.1">
        <property type="nucleotide sequence ID" value="XM_003511879.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007650565.1">
        <property type="nucleotide sequence ID" value="XM_007652375.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254067.1">
        <property type="nucleotide sequence ID" value="XM_027398266.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254068.1">
        <property type="nucleotide sequence ID" value="XM_027398267.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LVC8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011022.1">
        <property type="protein sequence ID" value="ENSCGRP00001007023.1"/>
        <property type="gene ID" value="ENSCGRG00001009492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770661"/>
    <dbReference type="KEGG" id="cge:100770661"/>
    <dbReference type="CTD" id="84328"/>
    <dbReference type="GeneTree" id="ENSGT00940000159001"/>
    <dbReference type="OMA" id="TKMMAGN"/>
    <dbReference type="OrthoDB" id="10262856at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.490:FF:000002">
        <property type="entry name" value="protein LZIC isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.490">
        <property type="entry name" value="Beta-catenin-interacting ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009428">
        <property type="entry name" value="ICAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036911">
        <property type="entry name" value="ICAT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47142">
        <property type="entry name" value="BETA-CATENIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47142:SF1">
        <property type="entry name" value="BETA-CATENIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06384">
        <property type="entry name" value="ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81730">
        <property type="entry name" value="beta-catenin-interacting protein ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-catenin-interacting ICAT" evidence="8">
        <location>
            <begin position="113"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027254067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027254068.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21541" checksum="0719CBC547A549B3" modified="2022-01-19" version="1">MASRGKTETSKLKQNLEEQLDRLMQQLQDLEECREELDTDEYEETKKETLEQLSEFHDSLKKIMSGNMTLVDELSGMQLAIQAAISQAFKTPEVIRLFAKKQPGQLRTRLAEMDRDLMVGKLERDLYTQQKVEILTALRKLGEKLREDDEAFLLANAGAALSQFEKVSTDLGSGDKVLALAGFEVEKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MA28</accession>
    <name>A0A8C2MA28_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L32, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Mrpl32</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027265206.1">
        <property type="nucleotide sequence ID" value="XM_027409405.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027295104.1">
        <property type="nucleotide sequence ID" value="XM_027439303.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MA28"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020222.1">
        <property type="protein sequence ID" value="ENSCGRP00001015978.1"/>
        <property type="gene ID" value="ENSCGRG00001016443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751170"/>
    <dbReference type="KEGG" id="cge:100751170"/>
    <dbReference type="CTD" id="64983"/>
    <dbReference type="GeneTree" id="ENSGT00390000014996"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 14" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678819" description="Large ribosomal subunit protein bL32m" evidence="10">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027265206.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22087" checksum="8F85DB4A4E88DC03" modified="2022-01-19" version="1">MHPTPARNMASALLLLHFPWPARPLRRCSELLQQLQRSWKGVASPQWAPALAVQGPSVLTELSHEASGNKEDSSFLDNIFWMAAPKNRRTIEVNLCRRRNSQKLIKIKNNIDICPECGHLKQKHVLCGYCYEKVRKETTKIRQQIWAQEGGPFKAPTVETVVLYTGEKPSEQDQGKRIVERNMKRPSWFTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MGQ0</accession>
    <name>A0A8C2MGQ0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neurotensin receptor type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Ntsr1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts (palmitoylated form) with GNA11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003503165.1">
        <property type="nucleotide sequence ID" value="XM_003503117.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027275698.1">
        <property type="nucleotide sequence ID" value="XM_027419897.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MGQ0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021193.1">
        <property type="protein sequence ID" value="ENSCGRP00001016949.1"/>
        <property type="gene ID" value="ENSCGRG00001017131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756437"/>
    <dbReference type="KEGG" id="cge:100756437"/>
    <dbReference type="CTD" id="4923"/>
    <dbReference type="GeneTree" id="ENSGT01120000271823"/>
    <dbReference type="OMA" id="CLCPLWG"/>
    <dbReference type="OrthoDB" id="9835116at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016492">
        <property type="term" value="F:G protein-coupled neurotensin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15355">
        <property type="entry name" value="7tmA_NTSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000217">
        <property type="entry name" value="neurotensin receptor type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003985">
        <property type="entry name" value="NT1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003984">
        <property type="entry name" value="NT_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF9">
        <property type="entry name" value="NEUROTENSIN RECEPTOR TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01479">
        <property type="entry name" value="NEUROTENSINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01480">
        <property type="entry name" value="NEUROTENSN1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 17 24" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="81"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027275698.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46921" checksum="DBF86618D4335635" modified="2022-01-19" version="1">MRLNSSVQQGAPVELGGQPFPRSQSGLEAMLLALGLGNGSSNTSESVLAAPNSDLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASGLLAVPMLFTMGLQNRSADGQHPGGLVCTPIVDTATVKVVIQVNTFMSFVFPMLVISILNTVIANKLTVMVRQANEQGVVCTVGTQNSLQHSTFNMSIDPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYISSAINPILYNLVSANFRQVFLSTLTCLCPGWRRRKKRPTFSRKPNSMSSNHAFSTSATRETVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MMZ9</accession>
    <name>A0A8C2MMZ9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 168, member A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6 7">Protein FAM168A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6 7" type="primary">Fam168a</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6 7">17A/GY</strain>
            <tissue evidence="6 7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM168 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003513630.1">
        <property type="nucleotide sequence ID" value="XM_003513582.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263603.1">
        <property type="nucleotide sequence ID" value="XM_027407802.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263604.1">
        <property type="nucleotide sequence ID" value="XM_027407803.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MMZ9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025200.1">
        <property type="protein sequence ID" value="ENSCGRP00001020956.1"/>
        <property type="gene ID" value="ENSCGRG00001019939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752186"/>
    <dbReference type="KEGG" id="cge:100752186"/>
    <dbReference type="CTD" id="23201"/>
    <dbReference type="GeneTree" id="ENSGT00390000005140"/>
    <dbReference type="OMA" id="WTNNINI"/>
    <dbReference type="OrthoDB" id="9940490at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029247">
        <property type="entry name" value="FAM168A/MANI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31844">
        <property type="entry name" value="MYELIN-ASSOCIATED NEURITE-OUTGROWTH INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027263603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027263604.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26184" checksum="60E3E9621665D30C" modified="2022-01-19" version="1">MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYATLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAPPPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAIYPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYVPPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MP54</accession>
    <name>A0A8C2MP54_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D(2) dopamine receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Dopamine D2 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Drd2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003498590.1">
        <property type="nucleotide sequence ID" value="XM_003498542.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267907.1">
        <property type="nucleotide sequence ID" value="XM_027412106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MP54"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025840.1">
        <property type="protein sequence ID" value="ENSCGRP00001021596.1"/>
        <property type="gene ID" value="ENSCGRG00001020389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751925"/>
    <dbReference type="KEGG" id="cge:100751925"/>
    <dbReference type="CTD" id="1813"/>
    <dbReference type="GeneTree" id="ENSGT00940000155539"/>
    <dbReference type="OMA" id="TPLKGNC"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098691">
        <property type="term" value="C:dopaminergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097648">
        <property type="term" value="C:G protein-coupled receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032795">
        <property type="term" value="F:heterotrimeric G-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021984">
        <property type="term" value="P:adenohypophysis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007195">
        <property type="term" value="P:adenylate cyclase-inhibiting dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048148">
        <property type="term" value="P:behavioral response to cocaine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048755">
        <property type="term" value="P:branching morphogenesis of a nerve"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021853">
        <property type="term" value="P:cerebral cortex GABAergic interneuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007631">
        <property type="term" value="P:feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007625">
        <property type="term" value="P:grooming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990384">
        <property type="term" value="P:hyaloid vascular plexus regression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045776">
        <property type="term" value="P:negative regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051481">
        <property type="term" value="P:negative regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060160">
        <property type="term" value="P:negative regulation of dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001223">
        <property type="term" value="P:negative regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051967">
        <property type="term" value="P:negative regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001976">
        <property type="term" value="P:nervous system process involved in regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007270">
        <property type="term" value="P:neuron-neuron synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030432">
        <property type="term" value="P:peristalsis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060158">
        <property type="term" value="P:phospholipase C-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043473">
        <property type="term" value="P:pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051586">
        <property type="term" value="P:positive regulation of dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900168">
        <property type="term" value="P:positive regulation of glial cell-derived neurotrophic factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060124">
        <property type="term" value="P:positive regulation of growth hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">17A/GY</strain>
        </source>
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        </citation>
        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000059">
        <property type="entry name" value="Plastin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000012">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000014">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000025">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF27">
        <property type="entry name" value="PLASTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="122"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="266"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="396"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="517"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035300424.1"/>
        </source>
    </evidence>
    <sequence length="630" mass="70535" checksum="9A647E9B58234BE9" modified="2022-01-19" version="1">MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKIFVVADSSKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSSISSEGTQHSYSDEEKVAFVNWINKALEDDPDCSHLLPMNPSDDSLFKSLADGILLCKMVNLSEPDTIDERAINKKKLTPFTVSENLNLALNSASAIGCTVVNIGAQDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLKEGEELEELMKLSPEELLLRWVNYHLTNAGWRTISNFSQDIKDSKAYFHLLNQIAPKGDRDDEPAIAIDLSGFNEKNDLKRAGFMLQEADKLGCRQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPDNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNEAKFSLVGIAGQDLNEGNATLTLALVWQLMRRYTLNVLSDLGEGEKVNDDIIIKWVNQTLKSANKNTSISSFKDKSISTSLPVLDLIDAIAPNAVRQEMIKRENLTDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKGLNRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MS96</accession>
    <name>A0A8C2MS96_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SRY (sex determining region Y)-box 7</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Transcription factor SOX-7 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Sox7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027246147.1">
        <property type="nucleotide sequence ID" value="XM_027390346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MS96"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027327.1">
        <property type="protein sequence ID" value="ENSCGRP00001023082.1"/>
        <property type="gene ID" value="ENSCGRG00001021410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754082"/>
    <dbReference type="KEGG" id="cge:100754082"/>
    <dbReference type="CTD" id="83595"/>
    <dbReference type="GeneTree" id="ENSGT00940000161092"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001706">
        <property type="term" value="P:endoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22046">
        <property type="entry name" value="HMG-box_SoxF_SOX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000008">
        <property type="entry name" value="transcription factor SOX-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033392">
        <property type="entry name" value="Sox7/17/18_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021934">
        <property type="entry name" value="Sox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF210">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12067">
        <property type="entry name" value="Sox17_18_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51516">
        <property type="entry name" value="SOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sox C-terminal" evidence="8">
        <location>
            <begin position="263"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027246147.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="41575" checksum="FCCB67BDDFABC941" modified="2022-01-19" version="1">MASLLGAYPWTEGLECPALESELSDGLSPPAVPRPPGDKGSESRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRPRRKKQGKRLCKRVDPGFLLSSLSRDQNTLPEKNGVGRGALGEKEDRGEYSPGAALPGLHSCYHEGAAGAPGSVDTYPYGLPTPPEMSPLDVLEPEQTFFSSSCQEEHGHPHCLPHLPGPPYSPEFTPSPLHCSHPLGSLALGQSPGVSMMSTVPGCPPSPAYYSPATYHPLHPNLQAHLGQLSPPPEHPGFDTLDQLSQVELLGDMDRNEFDQYLNTPGHPDSAAGAGNLSGHAPLSQGTTTGPTETSLISVLADATATYYNSYSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MYD2</accession>
    <name>A0A8C2MYD2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA decay activator protein ZFP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Zinc finger protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC113835924</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027273732.1">
        <property type="nucleotide sequence ID" value="XM_027417931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MYD2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030030.1">
        <property type="protein sequence ID" value="ENSCGRP00001025784.1"/>
        <property type="gene ID" value="ENSCGRG00001023281.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113835924"/>
    <dbReference type="KEGG" id="cge:113835924"/>
    <dbReference type="GeneTree" id="ENSGT00940000161584"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061158">
        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044344">
        <property type="term" value="P:cellular response to fibroblast growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071385">
        <property type="term" value="P:cellular response to glucocorticoid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097011">
        <property type="term" value="P:cellular response to granulocyte macrophage colony-stimulating factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060216">
        <property type="term" value="P:definitive hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000737">
        <property type="term" value="P:negative regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900153">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045577">
        <property type="term" value="P:regulation of B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048103">
        <property type="term" value="P:somatic stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007635">
        <property type="entry name" value="Tis11B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF174">
        <property type="entry name" value="MRNA DECAY ACTIVATOR PROTEIN ZFP36L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04553">
        <property type="entry name" value="Tis11B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="399"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027273732.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="50431" checksum="CDCABDE1B2568C60" modified="2022-01-19" version="1">MSTTLLSAFYDIDFLCKTEKSLANLNLNNMLDKKAVGTPVAAVPSSSFTPGFLRRHSASNLHALAHPAAPSPGSCSPKFPGAPNGGSCGPAGAGGPATYGQLKEPSGGGGGTTLVNKESKFRDRSFSENGERSQHLLHLQQQQQKGGSGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRAFGARDALHLGFAREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSSASSCSSSASSCSSTSAASTPSGAPTCCASAAAAAAAALLYGPGSSEDLLPPGGPCATCSATSCANNAFAFGPELSSLITPLAIQTHSFAAAAAAYYRSQQQGLAGPAPPPAQPPAAPAPPSPPFGFQLPRRLSESPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N135</accession>
    <name>A0A8C2N135_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Bile acid receptor isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Nuclear receptor subfamily 1, group H, member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">LOC100751364</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027249620.1">
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        <property type="entry name" value="HOLI"/>
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        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
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    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="247"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
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    </evidence>
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        <source>
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    <sequence length="504" mass="57223" checksum="3C00857B9B601342" modified="2022-01-19" version="1">MANTYVTASDGYCLAEPTQYYDILPEQIHYQLCDTDFQEASYCQYSTAQFPPALQSPSFQSHFNTYGLDPQYGSGGWCGLDACEASQSTYMFVHDDEDGFPGIQRSRPTCSLRWKGQDELCVVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYSCKNGGHCEMDMYMRRKCQECRLKKCKAVGMLAECLLTEIQCKSKRLRKNSKQKIALYSDLQVEDEGTDSKLVSSTTRYGKGVQESLALTQEEHHLMNTIVTAHQKFMTPLGAASLLLQEYSNPEVSFLRLSEAAVLNIQGLMNFTKGLPGFENLTNEDQTALQKESKTEVMFLHVAHLYSGKESTSGSIMRPSKPSARTREVHNQSSEENVYSLENFFKQGSSSATLTGITEEFVTSLTYFYRRMSELNITDTEYALLTATTVLFSDRPSLKNKQQVENLQEPVLQLLFKYSKLYHPEEPQHFAHLIGRLTELRTLSHRHSEILSTWKTKDPRLVTILSEKWNLHSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N1J5</accession>
    <name>A0A8C2N1J5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium voltage-gated channel, shaker-related subfamily, beta member 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Voltage-gated potassium channel subunit beta-3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Kcnab3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282844.1">
        <property type="nucleotide sequence ID" value="XM_027427043.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N1J5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030061.1">
        <property type="protein sequence ID" value="ENSCGRP00001025815.1"/>
        <property type="gene ID" value="ENSCGRG00001023295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755337"/>
    <dbReference type="KEGG" id="cge:100755337"/>
    <dbReference type="CTD" id="9196"/>
    <dbReference type="GeneTree" id="ENSGT00940000159306"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19160">
        <property type="entry name" value="AKR_KCAB3B_AKR6A9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000001">
        <property type="entry name" value="voltage-gated potassium channel subunit beta-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005983">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005402">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01293">
        <property type="entry name" value="Kv_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF3">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01580">
        <property type="entry name" value="KCNAB3CHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="90"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027282844.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43690" checksum="75BA07BE934AF5FB" modified="2022-01-19" version="1">MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPVGGGHGNPPGGGPKSRAALVPRPPAPAGALRESTGRSTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGVNLFDTAEVYATGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLQGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGLALYWGTSRWSAAEIMEAYSMARQFNLIPPVCEQAENHFFQREKVEMQLPELYHKIGVGSVTWSPLACGLITSKYDGRVQDTCKATVKGYQWLKEKVQSEDGKKQQARVMDLLPIAHQLDCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLLEHLGSLEVLSQLTPQTVMEIDALLGNKSHSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QC72</accession>
    <name>A0A8C2QC72_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nudix hydrolase 22</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Uridine diphosphate glucose pyrophosphatase NUDT22 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Nudt22</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_003511315.3">
        <property type="nucleotide sequence ID" value="XM_003511267.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264224.2">
        <property type="nucleotide sequence ID" value="XM_027408423.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QC72"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001572.1">
        <property type="protein sequence ID" value="ENSCGRP00001001461.1"/>
        <property type="gene ID" value="ENSCGRG00001001214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756578"/>
    <dbReference type="KEGG" id="cge:100756578"/>
    <dbReference type="CTD" id="84304"/>
    <dbReference type="OMA" id="TCYRDFI"/>
    <dbReference type="OrthoDB" id="242473at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052751">
        <property type="term" value="F:GDP-mannose hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008768">
        <property type="term" value="F:UDP-sugar diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055295">
        <property type="entry name" value="NUDT22/NUDT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835:SF1">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="117"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027264224.2"/>
        </source>
    </evidence>
    <sequence length="308" mass="33411" checksum="A6E28C8B1266DE77" modified="2022-01-19" version="1">MDPEVSLLLLCPPGGLSQEQVAVELSPAHDRRPLPGGDKTITAIWETRLQTQPWIFDAPKFRLHSAILASSSPQPQLLLNLGLTSYRDFLGTNWSSSASWLRQQGATDWGEKQAYLADPLGVGAILVTADDFLVFLRRSQQVAEAPGMVDVPGGHPEPQALCSGGIPQHKDLPGELVVRELFSSVLQEICDEVNVPPHTLSQPLLLGIACNETSAGRASAEFHVQCSLTSEEVRSYYMSGGPEAHESTGIIFVETQRVQRLQETEMWAQLCPSAKGAILLYNRHPPLQSGAGTSRLSHPSVPALSLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QDN5</accession>
    <name>A0A8C2QDN5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfotransferase</fullName>
            <ecNumber evidence="7">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Sult6b1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>thyroxine + 3'-phosphoadenylyl sulfate = thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26422"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:58910"/>
            <dbReference type="ChEBI" id="CHEBI:305790"/>
            <dbReference type="EC" id="2.8.2.n2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_003507909.1">
        <property type="nucleotide sequence ID" value="XM_003507861.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281672.1">
        <property type="nucleotide sequence ID" value="XM_027425871.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QDN5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006951.1">
        <property type="protein sequence ID" value="ENSCGRP00001004618.1"/>
        <property type="gene ID" value="ENSCGRG00001005892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757336"/>
    <dbReference type="KEGG" id="cge:100757336"/>
    <dbReference type="CTD" id="391365"/>
    <dbReference type="GeneTree" id="ENSGT00940000159084"/>
    <dbReference type="OMA" id="EFPILEC"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002302">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027281672.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35081" checksum="05CC6A987DEA05A3" modified="2022-01-19" version="1">MADKSKFIEYIHDALEKSKETALSHLFFTYQGIPYPVTMCTSETFQALDAFEARSDDIVIASYPKCGSNWILHIVSELIFAVSKKKYTCPEFPVLECGDTEKYQRMKLFPSPRILTTHLHYDKLPQSVFKNKAKILVIFRNPKDTAASFFHFHNDVPDIPSYASWDEFFRQFIQGQVSWGSYFDFAINWNKHIDDENVKFMLYEDLKENLLAGIKQISEFLGFSLTDEQIRAVSDQSTFQAMRENSQETHGAIGPFLFRKGEVGDWKNLFNETQNQEMDERFKECLAGTSLGVKLKYESHCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QIW7</accession>
    <name>A0A8C2QIW7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Rab11 family-interacting protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Rab11-interacting protein Rip11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Rab11fip5</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RAB11FIP4. Interacts with NAPG. Interacts with RO60. Interacts with RAB11A that has been activated by GTP binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Recycling endosome membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027284543.1">
        <property type="nucleotide sequence ID" value="XM_027428742.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001019254.1">
        <property type="protein sequence ID" value="ENSCGRP00001015015.1"/>
        <property type="gene ID" value="ENSCGRG00001015733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769415"/>
    <dbReference type="KEGG" id="cge:100769415"/>
    <dbReference type="CTD" id="26056"/>
    <dbReference type="GeneTree" id="ENSGT00940000158783"/>
    <dbReference type="OrthoDB" id="8956628at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010817">
        <property type="term" value="P:regulation of hormone levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000077">
        <property type="entry name" value="rab11 family-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2440:FF:000004">
        <property type="entry name" value="rab11 family-interacting protein 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037789">
        <property type="entry name" value="FIP_classI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746:SF14">
        <property type="entry name" value="RAB11 FAMILY-INTERACTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746">
        <property type="entry name" value="RAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="20">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="FIP-RBD" evidence="21">
        <location>
            <begin position="1242"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="341"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="463"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="666"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="828"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1082"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1116"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1154"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027284543.1"/>
        </source>
    </evidence>
    <sequence length="1309" mass="138331" checksum="BBE898E9894F6845" modified="2022-01-19" version="1">MALVRDTEPAAGSSRWLPTHVQVTVLRASGLRGKSSGAGSTSDAYTVIQVGREKYSTSVVEKTQGCPEWCEECSFELPPGALDGLLRAQEADGAPAPWASGPNASCELVLTTMHRSLIGVDKFLGRATVALDEVFRAGRAQHTQWYKLHSKPGKQEKERGEIQVTIQFTRNNLSASMFDLSAKDKPRSPFSKLKDKVKGKKKYELESASAILPSSALEDPELGSLAKMGKAKGFFLRNKLRKSSLTQSNTSLGSDSTLSSTSGSLVYQGPGAELLTRSPSHSSWLSTEGGRDSTQSPKLLTHKRTYSDEASQLRAAPPRALLELQGHLDGASRSSLCVNGSHVYNEEPQPPIRHRSSISGPFPPSSTLHSVPPRPSEEGPRSSDDSWGRGSRGTSSSEAVPGQEELSTQAKVLALGASCSGAEEGTRPPEGKPVQVATPMVASSEAMAEKERKPRMGLFHHHYHHHHQGLSRRGSVGEKGSPSLGASPHHSSTGEEKAKSSWFGLRESKEPTQKPSLDVSPQVESDPAAPPHPCSPWALAPPTPAPAAAPMLSTNLFAATSPAAATAAAATIVPGATPSGFLGVTNPFLTSLQSNPFFEELKADIALNSPSPAPSLPSASRASLAPLASPGKALPEWDDTFDIFAAGRLQPEAGSEILAPTEMGLEEDGLQDPGSGTMAVKATEPQRESGGGRGGSSIRLEPRVPVDSGLDQASTSVSDPGPLESSGTGPSSRAAHLHLRASAPASASTPDRELPASEVGAGQSPADSGTSLFSSPEVLSVWERLPGSDDIPGGQDEETPQDGSQLFQELNTVEDSWPWDVITISPTAEVVSSTMQGESDEVPPPQVQPESPAAVHPVESEGHPALQLELEPEQGLDEGPWPGPPPPKPPRLFTPTNSQVEEEEEEEKEEEENSGGPGVEEDTTPRELVVGSQDSKEEGVNPELEELHSLPSGTLMGEPELEELVGDTGAPGSGAFPPSPTSCLEGPIPRSRSSPSSTLLSQKVWGASDTGESLETQSQELAKEGSELLSATPQQADLWASEEEEDALNPFLRQESQDPPSLPSASPPGSRESPVHSSPEELPTPPEPAFTPPLLPPWASHRHGVPGPPCPPLPVAWPLTSSSSPPEESASPLGPLEFSPTGGSPTPYGEDRAAATPASPLALLPLETRPAEEPQLSGSPHPVKPLSAAPVEPSPDRKHPRTSLSTALSSGLEKLKTVTSGSIQSVVPASQLGPTVDTKRLKDSALLDQSAKYYHLTHDELIGLLLQRERELSQRDEHVQELESYIDRLLVRIMETSPTLLQISPAPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EY50</accession>
    <name>A0A9J7EY50_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dedicator of cytokinesis protein 9 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Dock9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027245460.1">
        <property type="nucleotide sequence ID" value="XM_027389659.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100768424"/>
    <dbReference type="KEGG" id="cge:100768424"/>
    <dbReference type="CTD" id="23348"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11698">
        <property type="entry name" value="DHR2_DOCK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000016">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000015">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF77">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="185"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="649"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1637"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1264"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027245460.1"/>
        </source>
    </evidence>
    <sequence length="2128" mass="242930" checksum="9AE299CCD5856CFB" modified="2023-06-28" version="1">MGCTTSVILFKGIRTVFERNCAYMCAQQGERNALEYTAYNWSKEDSELLISPCLAKPKLIEPLDYENVLVQKKTQILNDCLREVLLFPFDDFQTAILRRQGRYMRSTVPVNAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPSKAVKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDSHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDAQRLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPPSPTLMNGGQSPPAFQGAFHAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSIAHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNGRFSAVYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPTQLHEKHHLLLTFFHVSCDNSTKGSTKRKDAVETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELSMGRHYGPEIKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGNELVKYLKSLHAMEGHVVIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYIASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVKDVSPFPVNPGSIVKDEPLAVPTGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPERNPEKSNSLDKHQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTTELMDFFTISEVCLHQFQYMGKRYIARNQEGLGAIGHDRKSQTLPVSRNRTGVMHARLQQLGSLDNSVTFNHSYGHSEADVLHQSLLEANIATEVCLTTLDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSTFYEGRADMCASLCYEVLKCCNSKLGSIRTDASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEADLALQRESTVLPYSHNTCQRKSLGGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERKTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIQCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALVVNERLIKEDQLEYQEEMKANYREMAKELSGIMHEQICPLEEKTSVLPNSLHIFNAISGTPTSTVVQGLTSSSSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EYB6</accession>
    <name>A0A9J7EYB6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PACRG-like protein isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pacrgl</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027242775.2">
        <property type="nucleotide sequence ID" value="XM_027386974.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EYB6"/>
    <dbReference type="GeneID" id="100755632"/>
    <dbReference type="KEGG" id="cge:100755632"/>
    <dbReference type="CTD" id="133015"/>
    <dbReference type="OrthoDB" id="10258089at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF1">
        <property type="entry name" value="PACRG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027242775.2"/>
        </source>
    </evidence>
    <sequence length="248" mass="27288" checksum="01A81051E37D62FF" modified="2023-06-28" version="1">MQKSEYPGDVHLRNRATGNYDQRTSSSAQIKHSTTVQRSKSSSLTSSPEAARRVHPRPSDKLNPKTINPFGEQSRAPSAFAAIYSKGGIPCRLVHGSVKHRLQWECPPEILPFDPLLITLAEGLRETKHPYTFVSKEGFRELLLVKGAPEKAVPLLPRLIPVLKAALVHSDDEVFERGLSALVQLSVVVGPSLNGHLKLLLTSLSKRLMDKKFKEPITSALQKLEQHGGSASLIVIKSKIPTYCSICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZR5</accession>
    <name>A0A9J7EZR5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Lgalsl</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Does not bind lactose, and may not bind carbohydrates.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027243859.2">
        <property type="nucleotide sequence ID" value="XM_027388058.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EZR5"/>
    <dbReference type="GeneID" id="100755244"/>
    <dbReference type="KEGG" id="cge:100755244"/>
    <dbReference type="CTD" id="29094"/>
    <dbReference type="OrthoDB" id="9857238at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000046">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF98">
        <property type="entry name" value="GALECTIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="5">
        <location>
            <begin position="108"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027243859.2"/>
        </source>
    </evidence>
    <sequence length="240" mass="26365" checksum="E3DF3C2A60E65B25" modified="2023-06-28" version="1">MPPRADALRPSPPSSLRRRDLRAARFPSPPPPGPAAAPASGVRARPCERARPARTRARRRVPAARCRNMAGSVADSDAVVKLDDGHLNNSLGSPVQADVYFPRLIVPFCGHIKGGMRPGKKVLVMGIVDLNPESFAISLTCGDSEDPPADVAIELKAVFTDRQLLRNSCISGERGEEQSAIPYFPFIPDQPFRVEILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTIKINGDLQITKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F3D9</accession>
    <name>A0A9J7F3D9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cathepsin S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Ctss</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007629366.2">
        <property type="nucleotide sequence ID" value="XM_007631176.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249435.1">
        <property type="nucleotide sequence ID" value="XM_027393634.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F3D9"/>
    <dbReference type="GeneID" id="100751823"/>
    <dbReference type="KEGG" id="cge:100751823"/>
    <dbReference type="CTD" id="1520"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039912924" evidence="9">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="124"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027249435.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38460" checksum="DCB8DA456FF0B13A" modified="2023-06-28" version="1">MGTPAHATITRWLFWVPMVCCLAGDQLQRDPTLDHHWDLWKKFHGKQYKEKNEEEARRLIWEKNLKLVMLHNLEYSLEMHSYSLGMNHMGDMTSEEVLGQMRPLRVPSQRHRNSTYKSNPNQKLPDSMDWREKGCVTEVKYQGSCGSCWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEEKYGNKGCDGGFMTRAFQYIIDNGGIDSDASYPYKAVAEKCHYDSKSRAATCSRYMELPSGDEEALKEAVANKGPVSVGIDASHPSFFLYKSGVYDEPSCTENVNHGVLVVGYGNLDGKDYWLVKNSWGLHFGDQGYIRMARNNKNQCGIASYGSYPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F3E0</accession>
    <name>A0A9J7F3E0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC113832766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="10"/>
    <dbReference type="RefSeq" id="XP_027246800.1">
        <property type="nucleotide sequence ID" value="XM_027390999.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F3E0"/>
    <dbReference type="GeneID" id="113832766"/>
    <dbReference type="KEGG" id="cge:113832766"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000001">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000081">
        <property type="entry name" value="UDP-glucuronosyltransferase 2A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF45">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039963654" description="UDP-glucuronosyltransferase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027246800.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="60303" checksum="86B470FE51A7B736" modified="2023-06-28" version="1">MSVKMTAALLLLQLSGFFESGSGGKVLVWPMEYSHWLNLKTILDELVKKGHEVTVLIPSASLSYEVEDTSAIEFEIYPSSLSKAILEELYMEAINKYIYELPKLSFWRYFLMLQELFLLESEYSESLCKDVVLNKELMTKLQNSSFDVILADPFLPCGDLLAEILKTPLVFSLRFFPGSTYVKYSGGLPLPPSYVPPALSELSDQMTFMERVQNVLYVLCFDFWFQTFNEKKWNQLYTEVLGRPTTLLEMMGKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCRPAKPLPKEIEDFVQSSGEHGVVVFSLGSMVGKLTEERANVIAAGLAQIPQKVLWRFEGKKPDTLGSNTQLYKWIPQNDLLGHPKTRVFITHGGTNGLYEAIYHGVPVVGIPLFGDQFDNVVHMKIKGAGVRLDFLTMSSTDLLNAVKTVTTDPSYKENAMRLSRIHHDQPVKPLDRAVFWVEYVMRNKGAKHLRVAAHDLTWFQYHSLDVLGFLLACVVTVIFIITKCCLFCCQKFAKGGKKKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FAY9</accession>
    <name>A0A9J7FAY9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23 26">Anti-Muellerian hormone type-2 receptor</fullName>
            <ecNumber evidence="3 26">2.7.11.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24 26">Anti-Muellerian hormone type II receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25 26">MIS type II receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">Amhr2</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21 26">On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 26">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="26">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="26">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with type I receptor ACVR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 26">Membrane</location>
            <topology evidence="1 26">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 26">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3 26"/>
    <dbReference type="RefSeq" id="XP_027252500.2">
        <property type="nucleotide sequence ID" value="XM_027396699.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027295659.2">
        <property type="nucleotide sequence ID" value="XM_027439858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FAY9"/>
    <dbReference type="GeneID" id="100772657"/>
    <dbReference type="KEGG" id="cge:100772657"/>
    <dbReference type="CTD" id="269"/>
    <dbReference type="OrthoDB" id="669224at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005024">
        <property type="term" value="F:transforming growth factor beta receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23616">
        <property type="entry name" value="TFP_LU_ECD_AMHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000487">
        <property type="entry name" value="Anti-Muellerian hormone type-2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000349">
        <property type="entry name" value="Anti-Muellerian hormone type-2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015771">
        <property type="entry name" value="Anti-muellerian_hrmn_rcpt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF49">
        <property type="entry name" value="ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037392">
        <property type="entry name" value="AMHRII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 26" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 26" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 26 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 26 31" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 26" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 28" id="KW-0732">Signal</keyword>
    <keyword evidence="5 26" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039929310" description="Anti-Muellerian hormone type-2 receptor" evidence="28">
        <location>
            <begin position="16"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="199"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00065680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00072617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRNR" id="PIRNR037392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027252500.2"/>
        </source>
    </evidence>
    <sequence length="569" mass="61192" checksum="18F6551E34358085" modified="2023-06-28" version="1">MLGTLGLWTLLPAVAQVTPNSRTCVFFEAPGVRGSAKTLGEVLDERPGPPKSIRCLYSHCCFGIWNLTHGRARVEMQGCRDSDEPGCESLHCDPVPRAHPSPISTLLTCSCGSDFCNANYSHLPPSGNQGAPGPQDPQPTTGGPIWMALLLLGMFLVLLLGSIILALLQRKTCAVNGGSDPEPVSGGDCSEELPELNELCFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLPGLQHNHIVRFITAGQGGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLARTPASAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDRRPPPFQLAYEAELGSNPSACELWALAVEERRRPNIPSTWSCSATDPGGLRELLEDCWDADPEARLTAECVQQRLAALAYPQVASCFPDSGPKACTPLCPENCPSAPASATVPCRPQQGSCHLSVQQGLGSRSPQPVSTSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FL52</accession>
    <name>A0A9J7FL52_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Centrosomal protein of 78 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cep78</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis. Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. Involved in cilium biogenesis and controls cilium length. Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins. Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110. Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PLK4. Interacts with FAM161A. Interacts with IFT20; regulating IFT20 stability and localization. Interacts with TTC21A; regulating TTC21A stability and localization. Interacts with USP16; promoting USP16-dependent deubiquitination of tektins. Interacts with DCAF1/VPRBP; promoting localization of the EDVP complex to centrosomes. Interacts with CEP350; promoting CEP78 localization to centrosome and centriole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CEP78 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007653190.4">
        <property type="nucleotide sequence ID" value="XM_007655000.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262382.1">
        <property type="nucleotide sequence ID" value="XM_027406581.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FL52"/>
    <dbReference type="GeneID" id="100761244"/>
    <dbReference type="KEGG" id="cge:100761244"/>
    <dbReference type="CTD" id="84131"/>
    <dbReference type="OrthoDB" id="78308at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000057">
        <property type="entry name" value="Centrosomal protein of 78 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000070">
        <property type="entry name" value="Centrosomal protein of 78 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026212">
        <property type="entry name" value="Cep78"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110:SF3">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02062">
        <property type="entry name" value="CENTROSOME78"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="619"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="747"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="665"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027262382.1"/>
        </source>
    </evidence>
    <sequence length="783" mass="86358" checksum="885856218808AF25" modified="2023-06-28" version="1">MIDSVKLRRDSAADFFSHYEYLCALQDSVPLPAVRACLREGVLDFNADRLRVVDWAPLLSTLRVNRDLPLVAIKSSFQPWLGETGSDTRRVCRNRVPAIRSKDMSFQLCKALKGCLSISSVLRNLELNGLILRERDLTSLTKGLSKSASLVHLSLANCPIGDGGLEIVCQGIKNSVTLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDFDGMAGLRRITLNCNTLIGDQGASAFADSLSEDLWLRALDLQQCGLTSEGAKALLEALETNRTLVVLDIRKNLLIDHSMMKAVIKRVLQNGRSAKSEYQWITSPSVKESSKTAKQKKRTIVLGNSRKGKATIRIGLATKKPGNNGRKHGLSKDCYAPDPLPPGASGFLPWRTAERARRNRGFPLFKTRDMPNLLKQSDFPVTVTVESPSSSETDDFEDSSESAHEAPQKISIRQDTLQEKLNECLQQLKEERVIRLKADKRVSELEHENAQLRNINFSLSEALHAQSVTNMILDDEGVLGSIENSFQKFHAFLDLLKDAGLGQLATMAGIDQSDFHLVGRPQMNSTVSAPVEEQIALEEQKPDLEQTAVGQMQNIQFQKIRDDARIPLPLDTSQVPISTREASVASRDHLGASAPEPQEGSAVGLAARTGSPLADGISGSGSQREEAVLSKHSRCSEKASGKNEHSRKSAPEKHSGKDLLSDPGSPVNSKSKGIGDNRSLLNEPIKSESLKKHISVKKENRIVTVSSKTIKSKPNPVEHSENDTLGSDFEFQESIHSSART</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FNU8</accession>
    <name>A0A9J7FNU8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100760209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262574.1">
        <property type="nucleotide sequence ID" value="XM_027406773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FNU8"/>
    <dbReference type="GeneID" id="100760209"/>
    <dbReference type="KEGG" id="cge:100760209"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000012">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039902566" description="Lipase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027262574.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46077" checksum="1A546185DC0F88D4" modified="2023-06-28" version="1">MWWLLKTICLVHVIGNILCLLKPKPKNPEANMNISEIISYWGYKWEVYEVVSGDGYILPIYRIPCGKNETMDSSPKTVVYLQHGLTLSASSWILNPPSSSLGFLLADANFDVWLGNSRGNNYAMKHVYLDPNSEAFWDFSFDEQIKFDIPAIIDFIVNKTGQKQIYYVGHSQGTLLAYGAFATNPQVAQKIKANLALAPVVTTRYLSGAFRTIAYVDPTVIKQVFGEKDIMTGKDDNHIIQFICHRQTIGTVCNNLLTLLFGYNPQNLNESRIDVYAGQIPAGTSVRSILHFAQGIRTGLVQAYNWGSEALNMQHYNQSTPPIYNLENMKVQTVIWSGVNDILANPMDVKNLAAKTNNLVYHEKTEKYNHVDFLIGKDVTMLHMSKSLQIPSLDAFNLLERTKENQAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FQ03</accession>
    <name>A0A9J7FQ03_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cathepsin L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100766062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">To the propeptide regions of cysteine proteases.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003513369.1">
        <property type="nucleotide sequence ID" value="XM_003513321.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265486.1">
        <property type="nucleotide sequence ID" value="XM_027409685.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FQ03"/>
    <dbReference type="GeneID" id="100766062"/>
    <dbReference type="KEGG" id="cge:100766062"/>
    <dbReference type="OMA" id="ENQGCED"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2250:FF:000003">
        <property type="entry name" value="Cathepsin L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039897807" evidence="5">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="114"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027265486.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37298" checksum="3E4E35285E8AA3F2" modified="2023-06-28" version="1">MIPIFFLATLCLGVVPAAPTHDPSLDDEWQEWKTRHGKTYSMDEEGQKRAVWENNRKMIELHNEDYTKGKHGFHLEMNAFGDLTNIEFRQLMTGFQSMGTKEMNVFQEPLLGDVPKSVDWRNLSYVTPVKDQGQCSSCWAFSAVGSLEGQIFRKTGQLISLSEQNLVDCSWSYGNIGCFGGLMEYAFRYVKENRGLDTRVSYPYEARNGPCRYDPKNSAANVTDFVKIPISEDALMKAVATVGPISVGVDSHHHSFRFYKGGMYYEPHCSSSNLDHAVLVVGYGEESDGNKYWMVKNSWGQGWGMNGYIKMARDRNNNCGIATYAIYPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FT68</accession>
    <name>A0A9J7FT68_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="24">A disintegrin and metalloproteinase with thrombospondin motifs 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Adamts8</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027267536.1">
        <property type="nucleotide sequence ID" value="XM_027411735.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FT68"/>
    <dbReference type="GeneID" id="100754641"/>
    <dbReference type="KEGG" id="cge:100754641"/>
    <dbReference type="CTD" id="11095"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000048">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013277">
        <property type="entry name" value="Pept_M12B_ADAM-TS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF41">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01861">
        <property type="entry name" value="ADAMTS8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="14 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 17 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="11 17 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039912033" evidence="21">
        <location>
            <begin position="30"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="22">
        <location>
            <begin position="235"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 19">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="339"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="357"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="559"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027267536.1"/>
        </source>
    </evidence>
    <sequence length="906" mass="99358" checksum="4B068B4792D76381" modified="2023-06-28" version="1">MLLDPTAARWPPLLLLLLQLLPPPPLVCGAPAEPGTRSQASELLVPTRLPGSTSELAFHLSAFGQGFVLRLAPDASFLAPEFKIERLGGSGAAAGGEPGLRGCFFSGTVNGERESLAAVSLCRGLSGSFLLAGEEFTIQPQGAGDSLDQPHRLQRWGPGQHREDPGLAAAEVFPVPQGLKWEVEMGEGQGPERSDDEEDREQDKEGLRKKREDSSELPPPLRSKTRSKRFVSEARFVETLLVADASMAAFYGTDLQNHILTVMAMAARIYKHPSIRNSINLVVVKVLIVEEEGWGPEVSDNGGLTLRNFCNWQRRFNKPSDRHPEHYDTAILFTRQNFCGKGEQCDTLGMADVGTICDPNKSCSVIKDEGLQAAYTLAHELGHVLSMPHDDSKPCVRLFGSMGKYHMMAPFFIHVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSFLPLPTGLPGHSTLYELDQQCKQIFGPDFQHCPNTSVEDICVQLWCRHQDSDEPVCHTKNGSLLWADGTPCGPEHLCLYGSCVLKEEVENPKAVVDGDWGPWGPWGECSRTCGGGIQFSNRECDNPVPQNGGRFCLGERVKYQSCNTEECPPNGKSFREQQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPDTLSVCVRGQCVKAGCDHVVNSLKKLDKCGVCGGKGTTCRKVSGSFTSFSYGYNDIVTIPAGATNIDVKQRSHPGARNDGSYLALKTANGQYLLNGNLAISAIEQDILMKGTILKYSGSMATLERLQSFQALPEPLIVQLLTVSDEVFPPKVRYTFFVPNDMDFSMQNSKEKATTNIIQSLPHAEWVLGDWSECPSTCGGSWHRRTVECRDPSGQASDTCDEALKPEDVKPCGNQPCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FW26</accession>
    <name>A0A9J7FW26_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Osteocrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Ostn</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003495641.1">
        <property type="nucleotide sequence ID" value="XM_003495593.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268737.1">
        <property type="nucleotide sequence ID" value="XM_027412936.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FW26"/>
    <dbReference type="GeneID" id="100771159"/>
    <dbReference type="KEGG" id="cge:100771159"/>
    <dbReference type="CTD" id="344901"/>
    <dbReference type="OrthoDB" id="9900165at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021088">
        <property type="entry name" value="Osteocrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35353">
        <property type="entry name" value="OSTEOCRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35353:SF1">
        <property type="entry name" value="OSTEOCRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11037">
        <property type="entry name" value="Musclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039922648" evidence="1">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027268737.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14470" checksum="7F31210FFC0525C7" modified="2023-06-28" version="1">MLDRRLASTYFILAMIVMLWSSGKAFSVDLATEASEFGAAGLQSPPTGKEEKSATDLAAKLLLLDELVSLENDVFETKKKRSFPGFGSPLDRLSAGSVEHKGKQRKIVDHSKKRFGIPMDRIGRNRLSGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G7Y9</accession>
    <name>A0A9J7G7Y9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">cAMP-regulated phosphoprotein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100762699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA. Interacts with PPP2R2A; the interaction is direct and this interaction inhibits PP2A activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279041.1">
        <property type="nucleotide sequence ID" value="XM_027423240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G7Y9"/>
    <dbReference type="GeneID" id="100762699"/>
    <dbReference type="KEGG" id="cge:100762699"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF4">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 11" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027279041.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12336" checksum="E1EC941489CAF5AB" modified="2023-06-28" version="1">MSAEVPEAASAEEQKEMEDKVTSLEKAEEAKLKARYPHLGQKPGGSDFLRKRLQKGQKYFDSGNYNMAKAKMKNKQLPAAAPDKTEVTGDHIPTPQDLPQRKPSLVVSKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G8V1</accession>
    <name>A0A9J7G8V1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Myelin expression factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Myef2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027277774.1">
        <property type="nucleotide sequence ID" value="XM_027421973.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100763790"/>
    <dbReference type="KEGG" id="cge:100763790"/>
    <dbReference type="CTD" id="50804"/>
    <dbReference type="OrthoDB" id="610462at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12658">
        <property type="entry name" value="RRM1_MYEF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12660">
        <property type="entry name" value="RRM2_MYEF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12662">
        <property type="entry name" value="RRM3_MYEF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000033">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein M isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000034">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein M isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000625">
        <property type="entry name" value="myelin expression factor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034630">
        <property type="entry name" value="MYEF2_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034631">
        <property type="entry name" value="MYEF2_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF15">
        <property type="entry name" value="MYELIN EXPRESSION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="514"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027277774.1"/>
        </source>
    </evidence>
    <sequence length="591" mass="63324" checksum="45531C6B2AC564D1" modified="2023-06-28" version="1">MADADKPEAAAGDDGSQQQPAEPRRDPHPAEPXKPPRSSANGVKMENDESVKEEKSDLKEKSTGNKKANRFHPYSKDKNSGTGEKKGPNRNRVFISNIPYDMKWQAIKDLMREKVGEVTYVELFKDAEGKSRGCGVVEFKDEEFVKKALETMNKYDLSGRPLNIKEDPDGENARRALQRTGTSFQGSHASDVGSGLVNLPPSILNNPNIPPEVISNLQAGRLGSTIFVANLDFKVGWKKLKEVFSIAGTVKRADIKEDKDGKSRGMGTVTFEQAIEAVQAISMFNGQFLFDRPMHVKMDDKSVPHEDYRSHDSKTSQLPRGLGGIGMGLGPGGQPISASQLNISGVMGNLGPSGMGMDGPGFGGMNRIGGGVGFGGLEAMNSMAGFGGVGRMGELYRGAMTSSMERDFGRGDIGINRGFGDSFGRLGSAMIGGFAGRIGASNMGPVGTGISGSMGGMSSVTGGMGMGLDRMSSSFDRMGPGIGAILERSIDVDRGFLSGPMGSGMRDRLGSKGNQIFVRNLPFDLTWQKLKEKFSQCGHVMFAEIKMENGKSKGCGTVRFESPESAEKACRIMNGIKISGREIDVRLDRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G912</accession>
    <name>A0A9J7G912_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Lcmt2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RNF144B/IBRDC2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027277876.1">
        <property type="nucleotide sequence ID" value="XM_027422075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G912"/>
    <dbReference type="GeneID" id="100768317"/>
    <dbReference type="KEGG" id="cge:100768317"/>
    <dbReference type="CTD" id="9836"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000084">
        <property type="entry name" value="Leucine carboxyl methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000207">
        <property type="entry name" value="Leucine carboxyl methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027277876.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="75209" checksum="473F595E4F1FEE63" modified="2023-06-28" version="1">MGPRSRERRAGTVQSTNDSSALSKRSLAAHGYVRDAFAALLAPGPVRRTPLIHRGYYVRARAVRHCVRAFLQRTGALPAPARAQILSLGSGSDSLYFRLKAAGLLARTAVWEVDFPDVSRRKAERIRDVPELCSLTGPFQVGDSASALCFESSDYRILGADLRELPRLGEALDCAGLDATSPTLLLAEAVLTYLEPAGAAALIAWAAQRFPDALFVIYEQMKPRDAFGQIMLQHFGRLHSPLHGLELFPDVEAQVQRFLQAGWTACSALDLNEFYRRWLPAEERQRVETLEPFDEFEEWHLKCAHYFILAASRGDTLSETPVFPPSEASFRVDPASPTGFFSATVVTSDHQHSSLKRYGHTSILLSPGIIFSAGGFGEQGGRHCRVSTFHLLLRSCDSEWKGSQISSLGTGGQWDGRLYHTMTRLSDTQVLVLGGRLSPVSPASRALQLDLYRSEDNCPEIQNVTVTKAALEEGPMSRWRHSTTEVYYQNQRYLLVYGGRSVVEPVLSDCHFLHVETMAWVRIPVEGAAPEGRHSHSACSWQGGALIAGGLGASEEPLSSVFFLRPKPSGFLWESVDIQPPITPRYSHTAHVFNGKLLLVGGVWIHSSSVPGVTVINLTTGLSSEYQLDTTSVPWPLMLHNHSSVLLPEEQQILLTGGGGNCFSFGTYFNPHTVALDLSSLSTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GA98</accession>
    <name>A0A9J7GA98_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Matrix metalloproteinase-25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">Mmp25</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">May activate progelatinase A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="21">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027280664.1">
        <property type="nucleotide sequence ID" value="XM_027424863.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GA98"/>
    <dbReference type="GeneID" id="100774116"/>
    <dbReference type="KEGG" id="cge:100774116"/>
    <dbReference type="CTD" id="64386"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000016">
        <property type="entry name" value="Matrix metallopeptidase 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000016">
        <property type="entry name" value="Matrix metallopeptidase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF142">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 27" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="24" id="KW-0732">Signal</keyword>
    <keyword evidence="9 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039929816" description="Matrix metalloproteinase-25" evidence="24">
        <location>
            <begin position="26"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="25">
        <location>
            <begin position="115"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="22">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="22">
        <location>
            <begin position="370"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="22">
        <location>
            <begin position="416"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="22">
        <location>
            <begin position="465"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="21">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027280664.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="62086" checksum="62F1E6E31BF0E62F" modified="2023-06-28" version="1">MRLQALGLWLLLGLLLILLLQPVRAPIPRAQDVSLGVDWLTRYGYLPPADPSQAQLQSLEKLQDAIKIMQRFAGLPETGQMDPITIATMHKPRCSLPDILGAAGLVRRRRRYALSGSMWKKRTLTWSIQSFSQSSQLNQLTVRTLMSYALAVWAVESGLTFKEVDSQNQEADILIHFSRGYHQDTYPFDGPGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKVSNSPNGKPTRKPLASPPLPPALPPDSPSTPVPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPTHVRVIQAAYARPRDGRIILFSGPWFWVFQDRQLEGEARPLVEFGLPPGEEVDAVFSWPLNGKTYLIRGQQYWRYDEEAARLDPGYPRVLSLWEGAPPSPDDVTVSNTGDTYFFKGTHFWRFAKGSVKSESDSPQPMGPKWLDCPAPSSPKTTPKTGTCNCHCELNQAAEQPSATLLLPLLPLLAGAVFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GAX0</accession>
    <name>A0A9J7GAX0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Forkhead box protein K2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Interleukin enhancer-binding factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Foxk2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of SIN3A-, but not SIN3B-, containing multiprotein complexes. Interacts with DVL1, DVL2 (when phosphorylated) and DVL3; the interaction induces DVL2 nuclear translocation. Interacts with SUDS3. Interacts with BAP1 (when phosphorylated); leading to recruit the PR-DUB complex and repress FOXK2 target genes. Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex, at least composed of BAP1, one of ASXL1, ASXL2 or (probably) ASXL3 and one of MBD5 or MBD6. The PR-DUB core associates with a number of accessory proteins, including FOXK1, FOXK2, KDM1B, HCFC1 and OGT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027281659.2">
        <property type="nucleotide sequence ID" value="XM_027425858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GAX0"/>
    <dbReference type="GeneID" id="100752578"/>
    <dbReference type="KEGG" id="cge:100752578"/>
    <dbReference type="CTD" id="3607"/>
    <dbReference type="OrthoDB" id="691130at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20055">
        <property type="entry name" value="FH_FOXK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22723">
        <property type="entry name" value="FHA_FOXK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000025">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047397">
        <property type="entry name" value="FH_FOXK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047398">
        <property type="entry name" value="FHA_FOXK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="17">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="18">
        <location>
            <begin position="410"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="15">
        <location>
            <begin position="410"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="53"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="355"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="511"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027281659.2"/>
        </source>
    </evidence>
    <sequence length="812" mass="85397" checksum="B25E0637EB497D2C" modified="2023-06-28" version="1">MSMRTLLPIACIQGPPYWCDVLHDHVPLSAEPKQVHRNALRSWERHWGLSSRSVPALTSPHPPGFSAPPRPNLRRATPRTCGRSAARSPLPDLVAPLRAPRPLASGPVVAGPGARPCELPPSQLSSRPAASATVLGSRGPTTAPRASARQGARAIGRALAGDGGRGALSGAGAPPAGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPPGGGHGAAAPEPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSSEKREKQEAPESPVKPVQPHISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKMGRVIPSDLNLMADNSQPENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLVEQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPVEPEPGAAQPKLAVIQEARFAQSAPGSPLSSQPVLITVQRQLPPAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAVSVTSVAGLAPANTYTVAGQAVVTQAAVLAPPKAEPQENGDHREVKVKVEPVPAISPATLGAASRIIQTSQGAPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVVPTPTAVHSQVNNAVASPLHMLATHASASASLPTKRQNGDQAEQPELKRIKAEDGESIVIALSMDAPPAAMREKGIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GC95</accession>
    <name>A0A9J7GC95_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Unconventional myosin-Ic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Myosin I beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">Myo1c</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="23">Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM. Interacts with POLR1A. Interacts with POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts (via its IQ motifs) with CALM; this precludes interaction with YWHAB. Interacts with YWHAB; this precludes interaction with CALM. Interacts with RPS6. Interacts with actin. Interacts with LLPH. Interacts with GLUT4. Interacts (via its IQ motifs) with SH3BGRL3; the interaction is dependent on calcium and takes place at membrane ruffles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Stereocilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 26">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027282529.1">
        <property type="nucleotide sequence ID" value="XM_027426728.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GC95"/>
    <dbReference type="GeneID" id="100759064"/>
    <dbReference type="KEGG" id="cge:100759064"/>
    <dbReference type="CTD" id="4641"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060171">
        <property type="term" value="C:stereocilium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900078">
        <property type="term" value="P:positive regulation of cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000017">
        <property type="entry name" value="unconventional myosin-Ic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000013">
        <property type="entry name" value="unconventional myosin-Ic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF255">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19 26" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="22" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="18 26" id="KW-0505">Motor protein</keyword>
    <keyword evidence="16 26" id="KW-0518">Myosin</keyword>
    <keyword evidence="12 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="27">
        <location>
            <begin position="28"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="28">
        <location>
            <begin position="866"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="26">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00063700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00078851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027282529.1"/>
        </source>
    </evidence>
    <sequence length="1044" mass="119895" checksum="A5DC545FD91AA882" modified="2023-06-28" version="1">MRYRASALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWRVVRKALSVIDFTEDEVEDLLSIVASVLHLGNIHFAADEESNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQKTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSMNPIMSQCFDRNELSDKKRPETVATQFKMSLLQLVEILKSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHAPRCPENAFFLDHVRTSFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQALGSEPIQVKNPSVKYDRKGYKPRSRQLLLTPSAVVIVEDAKVKQRIDYTNLTGISVSSLSDSLFVLHVQREDNKQKGDVVLQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVVAPRLNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GEP5</accession>
    <name>A0A9J7GEP5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Keratin-associated protein 1-3 isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC103164462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027283568.1">
        <property type="nucleotide sequence ID" value="XM_027427767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GEP5"/>
    <dbReference type="GeneID" id="103164462"/>
    <dbReference type="KEGG" id="cge:103164462"/>
    <dbReference type="OrthoDB" id="9838409at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002494">
        <property type="entry name" value="KAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01500">
        <property type="entry name" value="Keratin_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027283568.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="18720" checksum="44F285E420FBA80A" modified="2023-06-28" version="1">MACCATSFCGFPTCSTGGTCGSSCCQPSCCQSSCCQPSCSQSSCCQPSCCQPSCSQSSCCQPSCSQSSCCQPSCCQPSCCGTGSGLEGGSGGMSCRVRWCRPDCRVEGTCLPPCCVVSSTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCQPSCSEPTCCQPSCSEPTCCQPSCSEPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GG10</accession>
    <name>A0A9J7GG10_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate kinase 4, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100774512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027284593.1">
        <property type="nucleotide sequence ID" value="XM_027428792.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GG10"/>
    <dbReference type="GeneID" id="100774512"/>
    <dbReference type="KEGG" id="cge:100774512"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027284593.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23005" checksum="07E13E5D4BC642F6" modified="2023-06-28" version="1">MREDAQNFGLQHLSSGHFLRENLKASMQVGDTAKQYLQKGLLVPDHAITRLMVSELETRSTQHCLLDGFPRTLEQVEEEALDRICDLVINLNIPFETLKDLLSRRWIHPSSGSVYNLDFNLPQVLGVDDITGEPLVQQEDDKPEAVAAKLRQLKDAAKPVIELYKSQGVLHQFSGTETNKIWPYVYTLFSNRITPIRSKEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJ61</accession>
    <name>A0A9J7GJ61_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Taste receptor type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100771227</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor T2R family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003510594.1">
        <property type="nucleotide sequence ID" value="XM_003510546.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285811.1">
        <property type="nucleotide sequence ID" value="XM_027430010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJ61"/>
    <dbReference type="GeneID" id="100771227"/>
    <dbReference type="KEGG" id="cge:100771227"/>
    <dbReference type="OrthoDB" id="8876749at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033038">
        <property type="term" value="F:bitter taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15021">
        <property type="entry name" value="7tm_TAS2R10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000042">
        <property type="entry name" value="Taste receptor type 2 member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007960">
        <property type="entry name" value="TAS2R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394:SF63">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2 MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05296">
        <property type="entry name" value="TAS2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3 13" id="KW-0919">Taste</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027285811.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35083" checksum="DDB8DFD8564DF343" modified="2023-06-28" version="1">MLSTAEGILLFISTSEAVLGILGDTVIGFVNCNDFIKNKKLSKIGLIISGLVISRIFLAWLLITDAYTKLFSGQLISVFNITEYMNYLWIIANNLSVWFATSLSVFYFLKIANFSHHMFLWLKKRIKVVFIFLTGCLLVTWLLSFPLVGKLIQENKRNTSQQFPIKKSEFIVEYVFVNVGVIFCFMVALTACFLLIISLWRHRRRMKSHVLGFRDLNTEAHVKAMKVLISFIILYMLYFIGIAIYIFCLFIPENKLLFLFGLTIACMCPCCHSLILILTNSQLKQYSVGLLQRLRCGEKGTDLRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GKN8</accession>
    <name>A0A9J7GKN8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TSC22 domain family protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tsc22d3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TSC-22/Dip/Bun family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289402.1">
        <property type="nucleotide sequence ID" value="XM_027433601.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GKN8"/>
    <dbReference type="GeneID" id="100760120"/>
    <dbReference type="KEGG" id="cge:100760120"/>
    <dbReference type="CTD" id="1831"/>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070236">
        <property type="term" value="P:negative regulation of activation-induced cell death of T cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21940">
        <property type="entry name" value="ZIP_TSC22D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000002">
        <property type="entry name" value="TSC22 domain family, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047862">
        <property type="entry name" value="TSC22/BUN_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF24">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01289">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027289402.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28095" checksum="E2DED4A53FBAA62E" modified="2023-06-28" version="1">MGLRDGAQDGVTSVEKRAPRESGLSFPGTLESQKASSAGAHLPAAPDTADQAASEPEKMAQSKTDCRSPVGLDCCNCCLDLANRSNLQKDSSGENKPGSPTVSNFRQLQEKLIFENLNTDKLNTIMRQDSLEPVLRDPCYLINEGICNRNIDQTMLSILLFFHSASGASVVALDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSRLSPEEPAPEAPETPEAPGGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GM65</accession>
    <name>A0A9J7GM65_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA-binding motif protein, X-linked 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rbmx2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed of at least 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IST3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289313.2">
        <property type="nucleotide sequence ID" value="XM_027433512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GM65"/>
    <dbReference type="GeneID" id="100773395"/>
    <dbReference type="KEGG" id="cge:100773395"/>
    <dbReference type="CTD" id="51634"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000218">
        <property type="entry name" value="RNA-binding motif protein, X-linked 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027289313.2"/>
        </source>
    </evidence>
    <sequence length="412" mass="47199" checksum="FA4B2B1B9B102AF9" modified="2023-06-28" version="1">MRQVLTCRSGSSSGSSASSSAASNLSWVIGCARPSSPHPEAHFLREEREGANMNPLTKVKLINELNEREAQLGVAEKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTVLAVDNFNGIKIKGRTIRVDHVSNYRAPQESEDMDEVTRELQEKGCGAKTPPSSSTEVSEDEDVKPTIKHKKDKKEKKKKKKEKEKMEHKVQAEPPSCSLPSGSRAVKEKDEEGPKKHSSKTSEKAQKSESREGRKNHTGFPDIRSSFHGRAEAPKWEPKKEKPKHEHKSSSRREGEEKSRGKDRGRSSGTHTSRHGGHSEGRSHRSRSRSHRSRSRSHRSRSRSRRSRRSRSRRSRSRRSRSLDKSYRHKKHRQSRERESYHASYRRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GNG1</accession>
    <name>A0A9J7GNG1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 4X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100766854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295604.1">
        <property type="nucleotide sequence ID" value="XM_035439713.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296389.1">
        <property type="nucleotide sequence ID" value="XM_035440498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GNG1"/>
    <dbReference type="GeneID" id="100766854"/>
    <dbReference type="KEGG" id="cge:100766854"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20678">
        <property type="entry name" value="CYP4B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF63">
        <property type="entry name" value="CYTOCHROME P450 4X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035295604.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50754" checksum="B251F45259827267" modified="2023-06-28" version="1">MEKLDEIVKKYPCAFPCWIGPFQAFFYIYDPDYAKIFLSRTDPKAQYVHQLMTPCIGRGLLNLDGPRWFQHRCLLTPAFHHDILKTCVDMMAHSVNTMLDKWEKSWSAQETTMEVFEHINLMALDIIMKCAFGQETNCQINRTYEPYMKATFELGEIISSYLYNFWHHHDIIFKFSPKGHCFQELGKVIHQCTEKIIQDRKKLLKDGIKQDDTQKSQDFLDIVLSAQAEDERAFSDTDLRSEVNTFMWAGHDASAVSISWLLYCLALNPEHQDRCRTEIRSILGDGSSITWDQLDEMSYTTMCIKETLRLIPPIPSISRELSKPLTLPDGHSLPGGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSDQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQVAPDLTRPPAFSSHTVLRPKHGIYLHLKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GNL9</accession>
    <name>A0A9J7GNL9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apolipoprotein L3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC100775029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294696.1">
        <property type="nucleotide sequence ID" value="XM_035438805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GNL9"/>
    <dbReference type="GeneID" id="100775029"/>
    <dbReference type="KEGG" id="cge:100775029"/>
    <dbReference type="OrthoDB" id="6363454at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF27">
        <property type="entry name" value="APOLIPOPROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05461">
        <property type="entry name" value="ApoL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035294696.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="36814" checksum="EC02F8587722FB36" modified="2023-06-28" version="1">MVAYLLDTRSTEALKFLLTEEEAWKQLVEGTDPDIEDEDMLQNDLQEKTERDEEEALSEALGDTIVNSDVDDEYHLQRELEAQKRFLDVYPQVKLELEQHIRKLHDLADKVDKVHRDCTITQVVANSTSAVSEVLKILGFALAPVTPGVSLGLSATGLGLGAAAAATSVSTSIVETASTASAEAEASQLGPTNQDTANTIKEVLEKSTPGLASVYEKSFQDLEVFKKNIDAINLVKTNPRLANNAKRLMTTGAVSARKTRQVQKSFGGTALAMTRRARVMGAANSGLSLVMDVVSLVEASKHLHEGAKADYAAELRKQARDLEQKLQDLIQVHDSLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GPW8</accession>
    <name>A0A9J7GPW8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protocadherin gamma-A7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100756169</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_035295443.1">
        <property type="nucleotide sequence ID" value="XM_035439552.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A9J7GPW8"/>
    <dbReference type="GeneID" id="100756169"/>
    <dbReference type="KEGG" id="cge:100756169"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_C"/>
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        <property type="entry name" value="Cadherin_CS"/>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
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    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039944456" evidence="14">
        <location>
            <begin position="29"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="689"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="348"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="453"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="579"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
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    </evidence>
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        </source>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035295443.1"/>
        </source>
    </evidence>
    <sequence length="895" mass="98179" checksum="E75E9A80376F81D9" modified="2023-06-28" version="1">MATGQRGAGYRGFVLLSIFLGTRWEARAGQILYSVSEETDKGSFVGNITKDLGLQPRELAERGVRIISKGKTQLFSLNPRSGSLVTAGRIDREEMCAQSPRCLISFNILIEDKMNLYPIEVEIMDVNDNAPRFLTEEINVKIMENAAPGMRFPLTEATDSDVGTNSLQKYQLSPNRHFSLAMQSGDDGTKYPELVLEKVLDREEEGIHHLVLTAYDGGDPPRSGTASIRVTVVDVNDHAPVFSLPRYQATVPENVPVGTRLLTVNAIDLDEGVYGEVTYSFRKVTPELLQIFHLSSLTGELSTLKDLDYEESSFYELEVQAQDGAGSLTKAKVLITILDVNDNAPEVTVTSVSSPVPEDTPPGTVVALFYLQDKDSGKNGEVTCSFPENLPFKLERSIDNYYRLVTAQNLDREKMSMYNITLKATDGGIPPLSTETHLPIHVSDTNDNPPAFSDSSYSIYIPENNLRGASIFSVTAQDPDGDKNAQITYALAEDTIQGVPVSSYISINSDTGVLYALGSFDYEQFQNLQLRVTARDSGDPPLSSNVSVNLFVLDKNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGPNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVANSIPDVLADLGSIKTPSEPDDSDITLYLVVAVATVSCVFLVFVTVLLALRLWRWHKSHMLQATGGGLEDVPASHFVGLDGVQAFLQTYSHEVSLTADSRKSHIIFPQPNYVDTLISQDSCEKRDSLLTSIDFQQCKGETPSNQTSMGSGDPNCDSHTFESNNLSMSHLQRLESLELHFPRSRRALLSKEPFLCLSFKYRFFQAKEGSFHRLELASKSIWNPEYPQHGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQ71</accession>
    <name>A0A9J7GQ71_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">Formin-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC113833746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035296013.1">
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
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            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
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        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035296013.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="38478" checksum="088159440C669AD2" modified="2023-06-28" version="1">MAASERPAPRTLSPRGPAGSHTPQEGAVERAELGFCSRGDPTSSSRSACRAPFTLARPAQPRFRDRGSGNRIPTLGPALNPIPRPRSRIRDQHSVSPGHRPRSLITDAALSPRPQPRSASRPRRLRPNQCGTQAPPPTQPTPTLRSPPTPPWRAGCPRGGKKSRRARLDSARPGATQNRGHAHLAPSGAHAAAWSTRSSRSRPAGRSRRGWSGPRGGCSSPSPAALAARARPPPPPPPPSPSAPQTPPAIRMGAAAPACSLGKPHVASLRTGSVRVLRPPPRPPRLCACASGLKASGPFSGVFEGATCRSVSVASGLRLLVSAPMPRAPSQRAVCSACVSGPPGLEGVAIPPSLPASETEAYPCIHTPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUT9</accession>
    <name>A0A9J7GUT9_CRIGR</name>
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        <submittedName>
            <fullName evidence="7">Dipeptidase 3</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">LOC100756154</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035297334.1">
        <property type="nucleotide sequence ID" value="XM_035441443.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312963.1">
        <property type="nucleotide sequence ID" value="XM_035457072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GUT9"/>
    <dbReference type="GeneID" id="100756154"/>
    <dbReference type="KEGG" id="cge:100756154"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000030">
        <property type="entry name" value="Dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF14">
        <property type="entry name" value="DIPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039954935" evidence="5">
        <location>
            <begin position="38"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035297334.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54044" checksum="2C9D5A5C621188E8" modified="2023-06-28" version="1">MQPAGLEGLRALGLRPLGHWLFLLGVLLLVPPLWVTCTQTTPSSSSIPTTPATSSANTTLGTPNASTTPGTTSDPRLREQARALMRDFPLVDGHNDLPLLLREQFQNKLQDVNLRNFTRGQTSLDRLREGLVGGQFWSAYIPCQTQDRDAVRLALEQIDLIRRMCAAYPELELVTSAEGLNNTQKLACLIGVEGGHSLDTSLSVLRSFYDLGVRYLTLTFTCSTPWAESATKFRHHFYTNISGLTSFGENVVEEMNRLGMMIDLSHASDTLVKQTLEVSRAPVIFSHSAARAVCDNLLNVPDDILQLLKKNGGIVMVTLSMGVLQCSLFANVSTVADHFDHIRTVIGSEYIGIGGNYDGSGRFPQGLEDVSTYPVLIEELLRRGWSEHELQGVLRGNLLRVFRQVEQERERSRAQSPVEVQFPDRQLSSTCHSHLLPQPQEKHQDTYFKVTKRPTNQVLRRASKASPCPIPDLMVAVTSLALILWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GWD0</accession>
    <name>A0A9J7GWD0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Epithelial sodium channel subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Amiloride-sensitive sodium channel subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gamma-NaCH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Nonvoltage-gated sodium channel 1 subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SCNEG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Scnn1g</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Component of the heterotrimeric epithelial sodium channel (ENaC) composed of an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. Interacts with WWP1 (via WW domains). Interacts with WWP2 (via WW domains); inhibits the channel. Interacts with the full-length immature form of PCSK9 (pro-PCSK9); inhibits ENaC by promoting its proteasomal degradation. Interacts with BPIFA1; the interaction is indirect via SCNN1B and inhibits the proteolytic maturation of SCNN1A and SCNN1G and the activation of ENaC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297507.1">
        <property type="nucleotide sequence ID" value="XM_035441616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GWD0"/>
    <dbReference type="GeneID" id="100764998"/>
    <dbReference type="KEGG" id="cge:100764998"/>
    <dbReference type="CTD" id="6340"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034706">
        <property type="term" value="C:sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000005">
        <property type="entry name" value="Amiloride-sensitive sodium channel subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.470.10:FF:000005">
        <property type="entry name" value="Amiloride-sensitive sodium channel subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004724">
        <property type="entry name" value="ENaC_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00859">
        <property type="entry name" value="ENaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF19">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 25" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="586"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035297507.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="74576" checksum="EE497FF2A35EE5A0" modified="2023-06-28" version="1">MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCMNTNTHGCRRIVVSRGRLRRLLWILFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKDFPEAKAQKRREARSMRSTGEGSQPRFLNLIPLLLFNENEKGKATDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDNSDCATYTFSSGINAIQEWYKLHYMNIMAQVPVDKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNRENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLIHQQNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPITNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQACSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQGQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARHQWQKAKDWWARRRAPLSSETHSSRQGQDNPALDTDDDLPTFTSAMRLPPAPEATVPGTPPPRYNTLRLDSAFSSQLTDTQLTNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GYR7</accession>
    <name>A0A9J7GYR7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 45 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Prostate cancer-associated protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Prostein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Slc45a3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Proton-associated sucrose transporter. May be able to transport also glucose and fructose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sucrose(out) + H(+)(out) = sucrose(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301568.1">
        <property type="nucleotide sequence ID" value="XM_035445677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GYR7"/>
    <dbReference type="GeneID" id="100755754"/>
    <dbReference type="KEGG" id="cge:100755754"/>
    <dbReference type="CTD" id="85414"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17313">
        <property type="entry name" value="MFS_SLC45_SUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001230">
        <property type="entry name" value="Solute carrier family 45 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF37">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035301568.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="60612" checksum="154FDFBCCF4A7AB6" modified="2023-06-28" version="1">MAPGALTALSIMIQRLWASRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDQWRGRYGRRRPFIWALSLGVLLSLFLIPRAGWLAGLLCPDTRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAFSVYAFMISLGGCLGYLLPAIDWDTSALAPYLGSQEECLFGLLTLIFLTCMAATLFVAEEAVLGPPEPAEGLLVPSVSSRCCPCRVGLAFRNLGTLFPRLHQLCCRTPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGIRMGSLGLFLQCTISLVFSLVMDRLVQRFGTRSVYLASVMTFPLAAGATCLSHSVVVVTASAALTGFTFSALQILPYTLASLYHREKQVFLPKYRGDAGCGGSEDSQTTSFLPGPKPGAPFPSGHVGPGSSILVPPPALCGASACDVSMRVMVGELPEAKVVTGRGICLDLAILDSAFLLSQVAPSLFMGSIVQLSHSVTAYMVSAAGLGLVAIYFATQVVFDKNDLAKYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZG9</accession>
    <name>A0A9J7GZG9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Kpna7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions in nuclear protein import.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300279.1">
        <property type="nucleotide sequence ID" value="XM_035444388.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316517.1">
        <property type="nucleotide sequence ID" value="XM_035460626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GZG9"/>
    <dbReference type="GeneID" id="100750897"/>
    <dbReference type="CTD" id="402569"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035300279.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="61650" checksum="FCBFF56CE36E1545" modified="2023-06-28" version="1">MPDLEAFEDRLKKFKYRGKDVSARRQQRIAANLQLRKAKKDEQTLKRRNISLFSNDLFSQEPVKVQASLILEDIIKGVNSSDPMVCLMATQAARKMLSQERNPPLKSIIEAGIIPKLVEFLKVSLLPNLQFEAAWALTNIASGTSEQTQAVVKGGAIQPLIELLSSPHMSVCEQAVWALGNIAGDGPAFRDNIISNNAIPKLLDLISTNIPVTFLRNITWTLSNLCRNKNPYPSQEAVLQILPTLSELLQHHDNEILSDTCWALSYLTEGHNDRIHHVVAMGVLPRLVELMTSPELIILTPSLRTMGNIVTGTDQQTQMAIDAGMLKVLGQLLRHPKPSIQKEAAWAMSNVAAGPKHHIQQLITCDLLPPLVALLRNAEFKIQKEAVWTVANFATGATQNQLAMLVHSGVLEPLLNLLTAPDLRIVTIILDIVSFFLQEADKMHEKQKLCLLMEEVGGIEKIEALQLHQNCHISHSALNIIEKHFSGVSNKGPVSWGYLLVAMLPTLLLQTWRSAMLTSLPHPPEFSWLPSWLLLFRWPLSIKQLVCELGGGSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H108</accession>
    <name>A0A9J7H108_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100751452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303548.1">
        <property type="nucleotide sequence ID" value="XM_035447657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751452"/>
    <dbReference type="KEGG" id="cge:100751452"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000010">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="72"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="273"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035303548.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53817" checksum="570AC1772FBF6640" modified="2023-06-28" version="1">MMPRMGSAARRLRRTHTAHAQSQRPCQNTGXQRLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYAKLYNPENIYLSEHGGGAGNNWARGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQYDKLWKRGAFLEQFRKEDIFKDNFEEMDRSREVVQELIDEYHAATRPDYISWGTQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H314</accession>
    <name>A0A9J7H314_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 9 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Lrrc9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035301763.1">
        <property type="nucleotide sequence ID" value="XM_035445872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751685"/>
    <dbReference type="KEGG" id="cge:100751685"/>
    <dbReference type="CTD" id="341883"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035301763.1"/>
        </source>
    </evidence>
    <sequence length="1459" mass="167300" checksum="0B110E94438E2B05" modified="2023-06-28" version="1">MIEIENLSRSEIIKELCLCNGLSYEMVGQEGSETSKLEMFFSGYPRIVGLSLFPNLSSLTIVAQDIKEISGLETCVQLKELWIAECCIEKIEGLQECRNLEKLYLYYNKISKIQNLERLMRLEVLWLNHNMIKNIEGLQMLKNLNDLNLAGNLISSIGRCLDPNEQLEKLNLSGNQITSFKDLTNLTRLPRLKDLSLNDPQYKSNPVCQLCNYSTHMLYHLPFLQRLDTFDVSAKQIKELADTTAMKKIMYYNMRIKTVERHLNEELEKLNDKKCKLQKLPEERIKLFHFAKKTLERELAELKGSSKGQNDNAPEAEKTRSNETVAQESSLQQKILTKLSALNERVTFWNKKLNEIEAIYHFGVKQKKKSHGLLTPFLLTELETVGNIHFEEGTRADDWFNSCYELILSRFCTWDFRAYGITGVKVKRVIKVNNRILRLKFEEKFQKCLDHEDMHDSESCRKMLECLFYVFDPEVPVKKKHLLQILERGFEESDTSKPPFKKEAVPLVNSLSMCECPRIEFLQQKYKDKMKSPAECDLLRYGTILIAKVFLGQSVQAREEEPISKANYPMVNSVFMPQRHFLNSIIGQRNCDCGYRQYKWFVFDHDLVLPEYIVEFEYITVVKVHSLFSTLNTVILEEGKKYSEGLVFSQDLKFDDEVMKMEPRIKPRPKLISLDDKTITSLAKTNIYSHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKTGDEINVLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLDGLFISEEETRAALNFINGTKITQLTLLQHSSSKEERPRMLSVWPSAKILTQISKLGPHFQLTGNWFLKITALNLDGQHLFEITNLEKLENLKWASFSNNNLSKMEGLESCVNLEELTLDGNCISKIEGIARLTKLSRLSMNNNLLTGLEKHTFDNMLHLHSLSLENNRITSLSALQKTFTLIELYISNNYIAVNQEIYNLKGLCNLVILDMFGNIIIWNQENYRLFVIFHLPELKALDGISIEPSEVENAKDLFGGRLTSDMIAERQGHSNFNQMQELNWTSSSIRTVDLIPVDHFRNVSNVNLQNNNLTSFSGLIYLPNVKVLCLNYNHIESIMPRVKPQSHLSNRQLLYQKVPSSGYGQQGATKLNRDSISNENLAPIMQSLEVLHLGYNGICNLVQLQLNRLRNLKFLFLQGNEITQVEGLDNLVILQELVVDHNRIRAFNETAFAKPSSLVTLHLEENRLRELGKLQSLVKLEKLFLGYNKIQEIAELEKLDVIPSLRELTVYGNPICRKMVHRHVLIFRLPNLQMLDGIPINADDRAKAEFHFSELQAKKNTFVPVTSSPSDGGSFCHMKASPIKITNVILPAGFSHFLGPDFALTPEVEGTAHPTPTPGFFVIPLLQLQLAAFHNSLAVVSPLDESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H3M5</accession>
    <name>A0A9J7H3M5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">Myo3b</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21 30">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 30">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Stereocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035302398.1">
        <property type="nucleotide sequence ID" value="XM_035446507.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772899"/>
    <dbReference type="KEGG" id="cge:100772899"/>
    <dbReference type="CTD" id="140469"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090103">
        <property type="term" value="P:cochlea morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051491">
        <property type="term" value="P:positive regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01379">
        <property type="entry name" value="MYSc_Myo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000006">
        <property type="entry name" value="Myosin IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000247">
        <property type="entry name" value="Myosin IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000010">
        <property type="entry name" value="Myosin IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036083">
        <property type="entry name" value="MYSc_Myo3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF1">
        <property type="entry name" value="MYOSIN-IIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 23" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1009">Hearing</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 23" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14 23" id="KW-0518">Myosin</keyword>
    <keyword evidence="11 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0844">Vision</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="27">
        <location>
            <begin position="331"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="23">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1106"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1177"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1281"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1107"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1288"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="424"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_035302398.1"/>
        </source>
    </evidence>
    <sequence length="1305" mass="148122" checksum="2CCE23F408BD54A3" modified="2023-06-28" version="1">MMLGLESLPDPMDTWEIIETIGKGTYGKVYKVANKRDGSLAAVKILDPVSDMDEEIEAEYNILRFLPNHPNVVKFYGMFYKVDHCVGGQLWLVLELCNGGSVTELVKGLLRCGERLDEAVISYILYGALLGLQHLHHHRIIHRDVKGNNVLLTAEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFKIPRNPPPTLLHPEEWCEEFNHFISQCLIKDFENRPSVTHLLDHPFIKGAQGNVLFLQKRLAKLLQDQKHLNPVAKTRHERMHTRRPYRVEDADKYCLEGDLVNLEVLDEDTIIYWLQKRYADGLIYTYVGDILIALNPFQTLSIYSPQFSRLYHGVKRASNPPHIFASADNAYQCLVTSSKDQCIVISGESGSGKTESAHLIVQHLTFLGKANNQTLRQKILQVNSLVEAFGNACTAINDNSSRFGKYLEMMFTPTGAVMGARISEYLLEKSRVIKQAAGEKNFHIFYYIYAGLYHQKRLSEFRLPEEKPPRYIAAETGRVMQDITSKESYQRRFEAIQHCFKIIGFTNKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALENAACVLCISPEELQEALTSHCVVTRGETIVRANTVDRAADVRDAMSKALYGRLFSWMVNRINTLLQPDKNICRAEDRMNVGILDIFGFEDFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKFFWRPKGVELCFGIRHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITASSRSLPPHFSAGRAKVDTLEMIRHPEETTNMKRQTMASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRILFEDFVKRYYYLAFRAHQTPPANKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVMLQAYTKGWLGARRYKRARQKREKAAIAIQSAWRGYDARRKFKQISHRRCESAAHTQAALQTSPDKKSCPNSEAESNNGHEETSSNFSAKADTDWHPQARSSPTGCDVALGHAFKAAGHTDAELSVAGTDESSSWTSHPAPAHQSLSPCEGPPKPGSKDGLSQKQRAPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSQRKPRKLGQIKVLDGEDQYYKCLSPETCAPEENDSSHTFFSPSSPRGDSVAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H3Z5</accession>
    <name>A0A9J7H3Z5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: lipocalin-15 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Lcn15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035302970.1">
        <property type="nucleotide sequence ID" value="XM_035447079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763749"/>
    <dbReference type="KEGG" id="cge:100763749"/>
    <dbReference type="CTD" id="389812"/>
    <dbReference type="OrthoDB" id="9627583at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF64">
        <property type="entry name" value="LIPOCALIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035302970.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27261" checksum="DD1B0A796B56C8FB" modified="2023-06-28" version="1">MSKRYKASCCAHVGRDQASAARTTLQFSGLWYVIAMVFDCKVLDNKDLLTSTRAVSAPVEGDLNVHMEFPRXVAYGCNQIEAEYLRMGSQGHFXSTCLAVMAAKREAGSFNIRDCIPTFSRVSLVWCSRGAPNSCPGFVLATCATSSAALHYLDVXHVCVDYSSFAEVYIYKEPDDTLSAMAQLPSERPGLPLSLAPLHFSVYPPAHSDQNLPPLGPSPASPHSFLTCLSSPLVGLVPPFSCPHLINLVQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4N6</accession>
    <name>A0A9J7H4N6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Retinal cadherin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Cdh4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cell membrane</location>
            <topology evidence="1 17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035302766.1">
        <property type="nucleotide sequence ID" value="XM_035446875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4N6"/>
    <dbReference type="GeneID" id="103160107"/>
    <dbReference type="KEGG" id="cge:103160107"/>
    <dbReference type="CTD" id="1002"/>
    <dbReference type="OrthoDB" id="6079678at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000022">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000027">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000045">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000287">
        <property type="entry name" value="Cadherin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014868">
        <property type="entry name" value="Cadherin_pro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF81">
        <property type="entry name" value="CADHERIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08758">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01820">
        <property type="entry name" value="DESMOCOLLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01055">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039926265" description="Cadherin-4" evidence="20">
        <location>
            <begin position="21"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="169"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="277"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="392"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="507"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="613"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035302766.1"/>
        </source>
    </evidence>
    <sequence length="915" mass="100273" checksum="FFC3583EC48246A3" modified="2023-06-28" version="1">MTTGSVLPLLLLGLSGALRAQHEDLTGREACKAGFSEEDYTALISPNVLEGEKLLRVKFSSCLGTKGTQYETNSLDFKVGADGTVFATRELKIPSEQVAFTVTARERQTAEQWDAMVRLLVAQTSSPHSGHKPQKGKAVALDPSQSPKDTLLPWPQHQSSSGLRRQKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREERASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTTSTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFTVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISVTDVNEAPYFPSNHKLIRLEEGVPTGTALTTFSAVDPDRFMQQAVRYSKLSDPANWLHINTSNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPQLLPKEAQICERPGLNAINITAADADMDPNIGPYVFELPFIPTTVRKNWTITRLNGDYAQLSLRILYLEAGVYDVPIIVTDSGNPPLSNTSIIKVKVCPCDENGDCTTIGAVAAAGLGTGAIVAILICIVILLTMVLLFVVWMRRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMEHVLSKAPGVRRVDERPVGAEPQYPVRPVVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4T2</accession>
    <name>A0A9J7H4T2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caspase recruitment domain-containing protein 9 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Card9</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035302441.1">
        <property type="nucleotide sequence ID" value="XM_035446550.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317331.1">
        <property type="nucleotide sequence ID" value="XM_035461440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4T2"/>
    <dbReference type="GeneID" id="100759255"/>
    <dbReference type="CTD" id="64170"/>
    <dbReference type="OrthoDB" id="8868836at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050700">
        <property type="term" value="F:CARD domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08809">
        <property type="entry name" value="CARD_CARD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000003">
        <property type="entry name" value="Caspase recruitment domain family, member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042142">
        <property type="entry name" value="CARD_CARD9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559:SF3">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="5">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="147"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="336"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035302441.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="63471" checksum="7433FE0B4E94D2CD" modified="2023-06-28" version="1">MSDYENDDECWSALESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSRELKRCKDENYDLAMRLAHLSEEKGSALMRNRDLQLEVDRLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELMWELQQEKDLLQARVQELEVSVQEGKLDRNSPYIQVLQEDWRQALQEHQEQANTIFSLRKDLRQAEALRTRCVEEREMFELQCLALRKDAKMYKDRIEAILQQMEEVSIERDQAMASREELHAQCAQSFQDKDELRKQVRELSEKADELQLQLFQSEGRLVAAEGRLKQQQLDMLILSSDLEDTSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFVAQSKEQLSQTHLPAPFLVQGTGPSSSEPPEKERRRLKESFENYRRKRALRKAQNSWRQDEGDRENTTGSDNTDTEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H6M3</accession>
    <name>A0A9J7H6M3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rhomboid-related protein 1</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Rhomboid-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Rhbdl1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035303987.1">
        <property type="nucleotide sequence ID" value="XM_035448096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H6M3"/>
    <dbReference type="GeneID" id="100771192"/>
    <dbReference type="KEGG" id="cge:100771192"/>
    <dbReference type="CTD" id="9028"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000006">
        <property type="entry name" value="rhomboid-related protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF4">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="16">
        <location>
            <begin position="323"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035303987.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="56802" checksum="65FA7F30630FB216" modified="2023-06-28" version="1">MPSCGSGSSCLVGDRSAQDVRESRRRVRVLGTRVLCPCTRRAGISVTLSELGAHRAEQVERAGRGGAERSAEQPLPASADPGPRPGSMDRSSLLQLIQEQGEYEVLEQPNQASCPARAWEQAGSSKQALTGPEVQLPSQPGSALWLEVGPPSTPPPQQLDPENTGFIGADTFAGLVHSHELPLDPTKLDMLVALAQSNERGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGLLDEPGLGIYKRFVRYVAYEILPCEVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGVLRISLLYLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAIFWNVFAYDLLGADIPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H6Q6</accession>
    <name>A0A9J7H6Q6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Interleukin-17 receptor E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Il17re</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035304920.1">
        <property type="nucleotide sequence ID" value="XM_035449029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H6Q6"/>
    <dbReference type="GeneID" id="100751042"/>
    <dbReference type="KEGG" id="cge:100751042"/>
    <dbReference type="CTD" id="132014"/>
    <dbReference type="OrthoDB" id="9894203at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030368">
        <property type="term" value="F:interleukin-17 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11530:FF:000006">
        <property type="entry name" value="interleukin-17 receptor E isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039465">
        <property type="entry name" value="IL-17_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027841">
        <property type="entry name" value="IL-17_rcpt_C/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583:SF5">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15037">
        <property type="entry name" value="IL17_R_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SEFIR" evidence="12">
        <location>
            <begin position="436"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035304920.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="69353" checksum="34854382EAA4B4C9" modified="2023-06-28" version="1">MIGTKSSGSMHLLQFPSNHTSLISFPHWALYLQDKNSAGLQWNWFPLLVKKSKSPPKSEFYWRRRRPASSQRKLLSSLSLSQEDHSISNPFPAISHGGPHCKRTQPLDTGGVEHFPRAGSQKRGGPEFSFDLLPEAQAIRVTIPPGPEASVRLCYQWALECEDMSSPFDTQKIVSGGHTVDLPYEFLLPCMCIEASYLQEDTVRCKKCPFQSWPEAYGSDFWKSVHFTDYSQNNQMVMAVTLRCPLKLEASLCQKQDPLLPCETLPNATAQESEGWYVLENVDLHPHLCFKFSFENSSHVECPHQSGSLPSWSVSMGTQGQRLTLHFSSTTYASFSAAWSNPGSGLDALMPPVYSISQTQGSVPVTFDLIIPFLNPGSCILVWRSDVQFASKHLLCPDVSHRHLGLLILALLGLTTLLGVVLVLLCRRLLPGPGQARPILLLHAADSEAQRRLVGALAELLRTALGGGRDVIVDLWEGTHVARIGPLPWFWAARERVVREQGTVLLLWNCAGPSPAGSGDPHPASIRTLLCAAPRRLLLAYFSRLCAKGDIPQPLRALPRYRLLRDLPRLLRALDARPATLATSWSHTGAKQCLQRRLELCHRLELAAKIDYQTSTDHPCGSSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H703</accession>
    <name>A0A9J7H703_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Extracellular calcium-sensing receptor isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC103163660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305077.1">
        <property type="nucleotide sequence ID" value="XM_035449186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H703"/>
    <dbReference type="GeneID" id="103163660"/>
    <dbReference type="KEGG" id="cge:103163660"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06365">
        <property type="entry name" value="PBP1_pheromone_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF529">
        <property type="entry name" value="VOMERONASAL 2, RECEPTOR 53-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="796"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="570"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035305077.1"/>
        </source>
    </evidence>
    <sequence length="858" mass="94459" checksum="C0E7DC95517E5F63" modified="2023-06-28" version="1">MWMSAGCLCGSALSQPRACLLPRQRPHFDRPGDVMVGGSFSIFRFSNSAPPDFAVPPAPLLPSEVSQWGYRVAQSFVFAIEEINRSAHLLPNLTLGFSIRNSGDSVHGAVYETLSFLTRQEEPVPNYTCQHGSPQAALVGDTRSALSVAMARVLGLYRFPQVSYGSSLPSLSDKIQFPSFLRTVTSDLTSCRAVTQLIIHFRWSWVIILAHDDDFGQQASSLASRELSPAGVCIEDTLHVPSHESSGKIELIVQKMQKCTARVVLVFLSNANFQIILHSLLGIRPSGQVWVSMDTMHMALALSIPGISQVLHGTFGLLYHSSRAIGFPEFLADLRPSQTPEDMFIKKFWESTFDCTWPHQSGRVRDGVQMCSGNESLKNKLYPFQEVSNIDATYTAVYSIAQALQDVIDQDGKGIDSQHFHSWQLLHAVRNVHFKTPDGIKIMFDANGDVVLKFDIYQGHKTPEGIFNLVPVGMVDPQAYVGNKMMVHLKEDLQVPSSVCSESCLPGSSQVPRVGAPQCCFDCSRCPKGQFADKKDMKRCLQCPKEQYSSHSRDRCLPRTEIFLAFEEPLGFMLALVALFLSGLAVLVLGVFVKHRDTPVVRANNRTLSYLLLMSLSLCSLCALLFLGRPSVTTCLLRQTTFAVVFTVAISSVLAKTLTVVLAFRATKPGGKIRLWLSPRASTSVVLIASFMQLVLCGVWLAISPPFPDRDMVSEPQHIVIQCQEGSGTLFLCVLGYLGILAGGTFFVAFLARGLPDVFNETKFLTFSTLLFCSVWTAFLPLYHSARGKSTVAVEIFSILASTAGLLGGIFIPKCYIILLKPERNTPAWLRQGHQALRIGSMRCSIEDVSSGPQHKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J5Y7</accession>
    <name>A0A9J7J5Y7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Importin subunit alpha-4 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Kpna3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027246181.2">
        <property type="nucleotide sequence ID" value="XM_027390380.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J5Y7"/>
    <dbReference type="GeneID" id="100761838"/>
    <dbReference type="KEGG" id="cge:100761838"/>
    <dbReference type="CTD" id="3839"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000004">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="14">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027246181.2"/>
        </source>
    </evidence>
    <sequence length="603" mass="66258" checksum="18183E180E7BA325" modified="2023-06-28" version="1">MTSGGREALRWGEGRVTATASRPAPRPLPARAAPQRRPRAAATSRSGRHGARAPPPPSPPARLAAAPPPPPQEQPPPEPRAAMAENPGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSTHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNFDPTANLQTKEFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JD77</accession>
    <name>A0A9J7JD77_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Mannan-binding lectin serine protease 2 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Mannan-binding lectin serine protease 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC118237732</name>
        <name evidence="18" type="synonym">LOC100756295</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18">17A/GY</strain>
            <tissue evidence="17 18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027254022.2">
        <property type="nucleotide sequence ID" value="XM_027398221.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254023.2">
        <property type="nucleotide sequence ID" value="XM_027398222.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JD77"/>
    <dbReference type="GeneID" id="118237732"/>
    <dbReference type="KEGG" id="cge:100756295"/>
    <dbReference type="KEGG" id="cge:118237732"/>
    <dbReference type="OrthoDB" id="9985152at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000059">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000012">
        <property type="entry name" value="mannan-binding lectin serine protease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF10">
        <property type="entry name" value="MANNAN-BINDING LECTIN SERINE PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 18" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044698815" evidence="14">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027254022.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027254023.2"/>
        </source>
    </evidence>
    <sequence length="190" mass="21371" checksum="9D3433C0F7AB2AFD" modified="2023-06-28" version="1">MQVPSPQLLIFLGLLWSSLTTLLASKWPEPVFGRLVSPGFPGNYANNQDRSWKLTAPPGYRLRLYFTHFNLELSYLCEYDFVKLSSGTKVLATLCGQESTDTGQAPGNDTFYSLGPNLEVTFHTDYSNEKPFTGFEAFYAAEDVDECRVSLGEDVPCDHYCHNYLGGYYCSCRAGYVLHQNKHTCSEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JFG0</accession>
    <name>A0A9J7JFG0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="23">HMG-CoA reductase</shortName>
            <ecNumber evidence="23">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Hmgcr</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:15991"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 23">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homotetramer. Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23">Endoplasmic reticulum membrane</location>
            <topology evidence="1 23">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="23"/>
    <dbReference type="RefSeq" id="XP_027257481.1">
        <property type="nucleotide sequence ID" value="XM_027401680.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027296276.1">
        <property type="nucleotide sequence ID" value="XM_027440475.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JFG0"/>
    <dbReference type="GeneID" id="100756363"/>
    <dbReference type="KEGG" id="cge:100756363"/>
    <dbReference type="CTD" id="3156"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000002">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004816">
        <property type="entry name" value="HMG_CoA_Rdtase_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00920">
        <property type="entry name" value="2A060605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="9 23" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 23" id="KW-0521">NADP</keyword>
    <keyword evidence="13 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="24">
        <location>
            <begin position="71"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022778"/>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027257481.1"/>
        </source>
    </evidence>
    <sequence length="897" mass="98211" checksum="3B086313DD45F64B" modified="2023-06-28" version="1">MRGSRDRVATMLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTTEHSKVSLGLDEDVSKRIEPSVSLWQFYLSKMISMDIEQVVTLSLAFLLAVKYIFFEQAETESTLSLKNPITSPVVTPKKAPDNCCRREPLLVRRSEKLSSVEEEPGVSQDRKVEVIKPLVVETESASRATFVLGASGTSPPVAARTQELEIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSTKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKDAFDSTSRFARLQKLHVTMAGRNLYIRFQSKTGDAMGMNMISKGTEKALLKLQEFFPEMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JJH3</accession>
    <name>A0A9J7JJH3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Shootin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Shtn1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the shootin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262674.1">
        <property type="nucleotide sequence ID" value="XM_027406873.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JJH3"/>
    <dbReference type="GeneID" id="100774279"/>
    <dbReference type="KEGG" id="cge:100774279"/>
    <dbReference type="CTD" id="57698"/>
    <dbReference type="OrthoDB" id="6111338at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044295">
        <property type="term" value="C:axonal growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001224">
        <property type="term" value="P:positive regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024849">
        <property type="entry name" value="Shootin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606:SF3">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="353"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="539"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017666"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027262674.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="71903" checksum="31E803E9A700A9E9" modified="2023-06-28" version="1">MMAMSAATQQSLLPGDGMDFSPDARSSTWFSIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDPTTDPDGAVETCVSVQCQEQIKELRDQIVSVQEEKKVLAIELENLKSKLVEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSMLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSALPDQQLLKALDENSKLIQLLEGERIQHKQKVKELEEQLENEALHKEIHNLRQQLELLEEDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPPPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPEAAEEVTDLKRQAVEEMMDRIKKGVHLRPVSQTASPKAKPDSLKGSESAVDELRGILGTLNKSTSSRSLKSLGPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPCPLTPEPGEGPRKLEGCTNPKVTFQPPSKGGYRRQGVGSEKPAEPVVVLDPVSTHEPQTKDQPVGKDQTEGEEEGGDTQPEPEEDSGGKRGEMDSSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JM63</accession>
    <name>A0A9J7JM63_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">Retinitis pigmentosa 9 protein isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Rp9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027267480.2">
        <property type="nucleotide sequence ID" value="XM_027411679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JM63"/>
    <dbReference type="GeneID" id="100768648"/>
    <dbReference type="CTD" id="6100"/>
    <dbReference type="OrthoDB" id="20809at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034585">
        <property type="entry name" value="PAP-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35252">
        <property type="entry name" value="RETINITIS PIGMENTOSA 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35252:SF1">
        <property type="entry name" value="RETINITIS PIGMENTOSA 9 PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027267480.2"/>
        </source>
    </evidence>
    <sequence length="262" mass="30797" checksum="53DA22BD85077EFC" modified="2023-06-28" version="1">MSSGAGSRRPREPAEQELQRRREQKRRRHDAQQLQQLKHLESLTAICGFTECFLHHHGNQHSMVDDQETDFTARECFLFTCLMKIAFCVSFSSYEKPPPGFIKEDETKPEDCIPDVPGNEHAREFLAHAPTKGLWMPLGREVKVMQCWRCKRYGHRTGDKECPFFIKGNQKLEQFRVAHEDPMYDIIRENKRHEKDVRIQQLKQLLEDSTSDEDESSSSSSGKEKRKKKKKKEKHKKKKKEKKKRKKRKHKASKSSESSDSE</sequence>
</entry>
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    <accession>A0A9J7JQG2</accession>
    <name>A0A9J7JQG2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger FYVE domain-containing protein 21 isoform X4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Zinc finger FYVE domain-containing protein 21 isoform X8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Zfyve21</name>
        <name evidence="8" type="synonym">LOC113836160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7 8">17A/GY</strain>
            <tissue evidence="7 8">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027272543.1">
        <property type="nucleotide sequence ID" value="XM_027416742.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274883.1">
        <property type="nucleotide sequence ID" value="XM_027419082.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035304982.1">
        <property type="nucleotide sequence ID" value="XM_035449091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JQG2"/>
    <dbReference type="GeneID" id="100767357"/>
    <dbReference type="CTD" id="79038"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15727">
        <property type="entry name" value="FYVE_ZF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.160">
        <property type="entry name" value="Zinc finger FYVE domain-containing protein 21, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032031">
        <property type="entry name" value="ZFYVE21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038632">
        <property type="entry name" value="ZFYVE21_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16696">
        <property type="entry name" value="ZFYVE21_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027272543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027274883.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28035" checksum="7329F6E99A39CA3C" modified="2023-06-28" version="1">MSSGVAARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKECPRCMQCDAKFDFITRKHHCRRCGKCFCDRCCSQKVPLRRMCFVDPVRQCAECALVSHREAEFYDKQLKVLLSGATFLVTFGDSEKPETMVCRLSNNQRCLILDGDSHHEIEIAHVCTVQILTEGFTPGEKDIHTYTSLLGSLLASEGSTRATGMFLQYTVPGAEAATQLRLMAGEDANGSKRQAAAWLAAMHKATKLLYESRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JRL0</accession>
    <name>A0A9J7JRL0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 19">Zinc finger protein 60 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18 19 20" type="primary">LOC100767190</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
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    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027430466.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286268.1">
        <property type="nucleotide sequence ID" value="XM_027430467.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286269.1">
        <property type="nucleotide sequence ID" value="XM_027430468.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286270.1">
        <property type="nucleotide sequence ID" value="XM_027430469.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JRL0"/>
    <dbReference type="GeneID" id="100767190"/>
    <dbReference type="KEGG" id="cge:100767190"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002308">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002715">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003928">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000020">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000638">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000579">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000338">
        <property type="entry name" value="zinc finger protein 383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000281">
        <property type="entry name" value="Zinc finger protein 558 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000895">
        <property type="entry name" value="Zinc finger protein 597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001630">
        <property type="entry name" value="Zinc finger protein 888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000330">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="233"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="317"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="345"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="429"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="569"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="653"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="962"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027286267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027286268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027286269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027286270.1"/>
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    </evidence>
    <sequence length="992" mass="114994" checksum="7B785F49BBB247FB" modified="2023-06-28" version="1">MASSGSQDMACGAVTFGDVAVDFSEEEWACLDSAQRAFYRDLMLETYSNLVTVVGSSISKPDLITLLEEEREPWMVVKEETDRPSQVGSSISKPDLITSLEQEREPWMVVKEETDRPSPDLESCYEAENTSQENHIYNRNLFKQGIKKLSKTFGLKASSFNNGPNYTTSNELPSYQGDGYQKISNKEKLLPNTFQTLAHNIEKTYECKECGKYFSCSSNLIQHHSIHTGEKPYECKECGKAFRLPQHFARHQKSHSGKRPFECDECGKGFQLPSVLKYHKTIHTGIKPFECEECGKSFKRFSHLVEHRIIHADVKPFECNECGKAFNRRSNLMQHQKIHSGERPFQCKECGKAFTVLAHLTRHQNIHTGEKSFECEQCGKIFSCGSFLVQHQSIHTGEKPFECNVCGKAFRLQVYLSEHQKTHTDEKPFKCMLCGSAFRRKYQLNEHQKIHTDEKPYQCKECGKLFRHHSNLIDHESIHTGKKPFECKECGKVFRLNIHLIRHQRLHSGERPFECKECGRAFHLPSQLNYHKIVHTSIKPFECKVCGKSFKHVSTLVQHRIIHADVKPFECNECGKAFNRRSNLMQHQKIHSGERPFQCKECGKAFTVLALLTRHQNIHSGEKSFECKECGKIFSCGSFLVQHQSIHTGEKPFECNVCGKAFRLQVYLSEHQKTHTGEKPFKCMLCGSAFRRKYQLNEHQRIHTDEKPYQCNECGKYFRRRSNFTEHQSIHTGKKPFDCKECGKVFRLNIHLIRHQRCHSGERPFGCDECGRTFHLPSQLNYHKSILHTGQKIFECEECGKSFKRVSSLVEHRIIHAGVKPYECNECGKAFSRRSNLMQHQKIHSGERPFQCKECGKGFTLLAQLTRHQNIHTGEKSFECEQCGLAFRLKSQLSQHQRIHTDVKLFQCKECGKDFIHSTGLRIHQRIHTGEKPFQCKECGEAFQYHYQFLAHFRIHTGKNPYECTQCGKYFTCDRDLKLHQRIHTVEKLYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUB5</accession>
    <name>A0A9J7JUB5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L18 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Rpl18</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007647457.1">
        <property type="nucleotide sequence ID" value="XM_007649267.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276396.1">
        <property type="nucleotide sequence ID" value="XM_027420595.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JUB5"/>
    <dbReference type="SMR" id="A0A9J7JUB5"/>
    <dbReference type="GeneID" id="100774500"/>
    <dbReference type="KEGG" id="cge:100774500"/>
    <dbReference type="CTD" id="6141"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="7">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027276396.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21645" checksum="9489EFE201ABF7A1" modified="2023-06-28" version="1">MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTVTDDVRILEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALESPKGRGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JXS2</accession>
    <name>A0A9J7JXS2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein chibby homolog 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC113836821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027283445.2">
        <property type="nucleotide sequence ID" value="XM_027427644.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JXS2"/>
    <dbReference type="GeneID" id="113836821"/>
    <dbReference type="KEGG" id="cge:113836821"/>
    <dbReference type="OrthoDB" id="2145765at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028118">
        <property type="entry name" value="Chibby_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21533">
        <property type="entry name" value="LEUCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21533:SF17">
        <property type="entry name" value="PROTEIN CHIBBY HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14645">
        <property type="entry name" value="Chibby"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_027283445.2"/>
        </source>
    </evidence>
    <sequence length="144" mass="16634" checksum="0E2EE5051FDC7EF6" modified="2023-06-28" version="1">MSTFYLLDYRTRQAELGLNYGSPRTRLSDEAFVFRGGRWTAERQRARPRSPLPSPTGAAWKPPVQLIKNQVLLEENNYLKLQQELLMDMLTETTARLLLLEKKVDGESDSTSTARAWQRKMRKHEAASMLVIQPRALESREVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K2E2</accession>
    <name>A0A9J7K2E2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C1GALT1-specific chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">C1galt1c1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with core 1 beta-3-galactosyltransferase (C1GALT1), probably not with the soluble active form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003516099.2">
        <property type="nucleotide sequence ID" value="XM_003516051.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306155.1">
        <property type="nucleotide sequence ID" value="XM_035450264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K2E2"/>
    <dbReference type="GeneID" id="100751243"/>
    <dbReference type="CTD" id="29071"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000016">
        <property type="entry name" value="C1GALT1-specific chaperone 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF2">
        <property type="entry name" value="C1GALT1-SPECIFIC CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035306155.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38448" checksum="5EB45F74C2604F4E" modified="2023-06-28" version="1">MEIEYLFNLKSFVMARGKMLSESSSFLKGVMLGSIFYALITTLGHIRIGHRNRTHHHEHHHLQAPNKEDISKISAAERMELSKSFRVYCIVLVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINVDTDDMWLMMRKAYKYAFDKYKEQYNWFFLARPSTFAVIENLKYFLLKKDPSQPFYLGHTVKSGDLEYVSVDGGIVLSIESMKRLNSLLSVPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADRKDVFNTKSVGLFIKEAMSNHPNQVVEGCCSNMAVTFNGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3F5</accession>
    <name>A0A9J7K3F5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Platelet endothelial aggregation receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Multiple epidermal growth factor-like domains protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Pear1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. May be involved in the early stages of hematopoiesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation. Interacts (via extracellular domain) with SVEP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the MEGF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307598.1">
        <property type="nucleotide sequence ID" value="XM_035451707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3F5"/>
    <dbReference type="GeneID" id="100750684"/>
    <dbReference type="KEGG" id="cge:100750684"/>
    <dbReference type="CTD" id="375033"/>
    <dbReference type="OrthoDB" id="10268124at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010572">
        <property type="term" value="P:positive regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000007">
        <property type="entry name" value="multiple epidermal growth factor-like domains protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000019">
        <property type="entry name" value="Platelet endothelial aggregation receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000021">
        <property type="entry name" value="Platelet endothelial aggregation receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000025">
        <property type="entry name" value="Platelet endothelial aggregation receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057138">
        <property type="entry name" value="EGF_PEAR1L-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052485">
        <property type="entry name" value="MEGF_diff_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24052">
        <property type="entry name" value="DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24052:SF12">
        <property type="entry name" value="PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23301">
        <property type="entry name" value="EGF_PEAR1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039906521" description="Platelet endothelial aggregation receptor 1" evidence="22">
        <location>
            <begin position="21"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="24">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="577"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="848"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="923"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="852"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="963"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038377"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00054256"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00065997"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074825"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082296"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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    </evidence>
    <sequence length="1033" mass="110181" checksum="AC0F170193F38386" modified="2023-06-28" version="1">MLPLLRFLLLLALGLRLARTLNSNDPNVCTFWESFTTTMKESHLRPFSLLPAEPCDRPWEDPQTCSQPTVVYRTVYRQVVKTDSRPRLQCCGGYYESSGACVPLCAQECVHGRCVAPNRCQCAPGWRGDDCSSECAPGVWGPRCDKLCHCGNSSSCDPKSGVCFCPSGLQPPNCLQTCSPGHYGPDCQFGCHCHGASCDPQNGACFCPPGKTGPSCSVPCSQGTAGYFCPRTNPCQNGGVFQVPQDSCSCPPGWMGDICSLPCPEGFHGPNCTHECRCHNGGLCDRFTGQCHCAPGYIGDRCREECPVGRFGQDCAETCDCAPGARCFPANGACLCEHGFTGDRCNERLCPDGLYGLSCQEPCTCDPDHSLSCHPMHGECACQPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGICLADSGLCRCAPGYTGPHCANLCPPDTYGINCSSHCSCENAIACSPIDGTCVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEGVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASVCDCDHSDGCDPVHGHCQCQAGWMGTRCHLPCPEGFWGANCSNTCTCKNGGTCVPESGNCVCAPGFRGPSCQRPCQPGRYGKRCVPCKCNNHSSCHPSDGTCYCLAGWTGPDCSESCPPGHWGLKCSQPCQCHHGGTCHPQDGSCACTPGWTGPYCLEGCPPGVFGVNCSQLCQCGPGERCHPETGACVCPPGHSGAPCKLGIQESSTIMPTSPVTHNSLGAVIGIAVLGTLVVALVALFIGYRHWQKGKEHEHLAVAYSSGRLDGSDYVMPDVSPSYSHYYSNPSYHTLSQCSPNPPPPNKVPGSQLFVTSQAPERPGRARDNHATLPADWKHRREPHDRGSSHLDRSYSCSYSHRNGPGPFCHKGPTSEEGLRASVMSLSSENPYATIRDLPGLPGEPRESSYVEMKGPPSGSPPRLPLHIRDSQQRQLQPQRDSGTYEQPSPLSHNQESVGSTPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPPSPPPRRQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3W0</accession>
    <name>A0A9J7K3W0_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">A-kinase anchor protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118237741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035294658.1">
        <property type="nucleotide sequence ID" value="XM_035438767.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="118237741"/>
    <dbReference type="KEGG" id="cge:118237741"/>
    <dbReference type="OrthoDB" id="8931760at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010739">
        <property type="term" value="P:positive regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090036">
        <property type="term" value="P:regulation of protein kinase C signaling"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028540">
        <property type="entry name" value="AKAP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23209">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23209:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035294658.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10205" checksum="20A278FC94011AD2" modified="2023-06-28" version="1">MGAGSSTEQRSPEQPAGSDTPGELELSGHGPAAEEPGAGGEPADADPATKLLQKNGQLSAVNGVAEQGDVHVQEENQDGQEEEVIEDGYIWKLHGGNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4T5</accession>
    <name>A0A9J7K4T5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interleukin-2 receptor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Il2ra</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297606.1">
        <property type="nucleotide sequence ID" value="XM_035441715.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316302.1">
        <property type="nucleotide sequence ID" value="XM_035460411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K4T5"/>
    <dbReference type="GeneID" id="100764797"/>
    <dbReference type="KEGG" id="cge:100764797"/>
    <dbReference type="CTD" id="3559"/>
    <dbReference type="OrthoDB" id="9833060at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019976">
        <property type="term" value="F:interleukin-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004911">
        <property type="term" value="F:interleukin-2 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.230">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015486">
        <property type="entry name" value="IL-2_rcpt_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10573">
        <property type="entry name" value="INTERLEUKIN-2 RECEPTOR ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10573:SF0">
        <property type="entry name" value="INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0768">Sushi</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="18">
        <location>
            <begin position="143"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035297606.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32921" checksum="867CB39235A99E84" modified="2023-06-28" version="1">MAPKEWHLGLTSGLHTQRHDRKTLMDVCTSNSSSSSSSSSSSSSSSEMCVQNPPEVAYATFKAPAYKSGTILNCECKRGFRRIKELVYMVCLENSWSESCQCTSNSNSNLRKQVTPKPEDQKDWQTTEMQKSTQSVHQGNLPGHCREPPPWEHEDTKRIYHFMVGQRLHYECLPGYKALQKGPAISICKMICGNTGWTQPQLTCVDEREHHQFPASEESQGSGDPFPESETSCPITTTDFQFLTEAATTMETFILTAEHQIAVASCVFLLISILLLSGLTWQRRWKKSRRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K556</accession>
    <name>A0A9J7K556_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 431-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC113838011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035309826.1">
        <property type="nucleotide sequence ID" value="XM_035453935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K556"/>
    <dbReference type="GeneID" id="113838011"/>
    <dbReference type="KEGG" id="cge:113838011"/>
    <dbReference type="OrthoDB" id="9865365at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000638">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000156">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF176">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035309826.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39419" checksum="33F0061877C4E17D" modified="2023-06-28" version="1">MQAGENSSIYTKCDKAFENNSYLQSHESKHTGEKSYECNQCGKAFAYHSYLLIHQRRHRGEKTYKCNQCGKAFTHHSTLQMHKNVHTGEKPYECNQCGKAFARHSHLQSHKRTHTGEKPYECNQCGKAFAQHSTLQMHKRTHTGEKPYECNQCGKAFARHSHLQSHKRTHTGEKPYECNQCGKAFSHHSHLQMHRRTHTGEKPYECNQCGKAFAQHSTLQMHKRTHTGEKPYECNQCGKAFAQHSNLQMHKRTHTGEKPYECNQCGKAFSRQTTLQMHERTHNGEKPYECNQCGKAFAQYSNLYMHKKTHSGEKPYECNQCGKAFSHHSTLRKHERTHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K8J0</accession>
    <name>A0A9J7K8J0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Nitric oxide synthase 1</fullName>
            <ecNumber evidence="8">1.14.13.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Constitutive NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">NC-NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">NOS type I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Neuronal NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Nitric oxide synthase, brain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Peptidyl-cysteine S-nitrosylase NOS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="primary">Nos1</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="37" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
            <tissue evidence="38">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:19898"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <location evidence="5">Sarcolemma</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="8"/>
    <dbReference type="RefSeq" id="XP_035300067.1">
        <property type="nucleotide sequence ID" value="XM_035444176.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313481.1">
        <property type="nucleotide sequence ID" value="XM_035457590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758127"/>
    <dbReference type="KEGG" id="cge:100758127"/>
    <dbReference type="CTD" id="4842"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045745">
        <property type="term" value="P:positive regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903522">
        <property type="term" value="P:regulation of blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06202">
        <property type="entry name" value="Nitric_oxide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06708">
        <property type="entry name" value="PDZ_nNOS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.440.10:FF:000001">
        <property type="entry name" value="Endothelial nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000002">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000069">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1230.10:FF:000001">
        <property type="entry name" value="Nitric oxide synthase, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF2">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000333">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-0274">FAD</keyword>
    <keyword evidence="12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0288">FMN</keyword>
    <keyword evidence="11 32" id="KW-0349">Heme</keyword>
    <keyword evidence="20 32" id="KW-0408">Iron</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 32" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0770">Synapse</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PDZ" evidence="34">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="35">
        <location>
            <begin position="755"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="36">
        <location>
            <begin position="1024"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="32">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00031302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00031374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00032538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00035211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00035474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR000333-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="RefSeq" id="XP_035300067.1"/>
        </source>
    </evidence>
    <sequence length="1459" mass="163827" checksum="9AA37E3CD96368A9" modified="2023-06-28" version="1">MEEHTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPSTKAVDLSHQTSASKDQPLATGRVTGPGNGPQHAQGNGQESGSVSQANGLAIDPTMKSTTANLQDSGEHDELLKEIEPVLSLLNSGGKVANRGGPAKAEMKDTGVQVDRELDGKLHKALPLGSENDRVFNDLWGKGSVPVVLNNPYSEKEQPPASGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKYPEPLRFFPRKGPSLSHADSEAHGLVAVRDSQHRSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPELTQGLSNVHKKRVSAARFLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHMVKVEMLEERNTALGVISNWKDEPRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPIHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAEPVYRALKEQGGHVYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KCM7</accession>
    <name>A0A9J7KCM7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-sarcoglycan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Sgcb</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <location evidence="3">Sarcolemma</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027239961.1">
        <property type="nucleotide sequence ID" value="XM_027384160.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309294.1">
        <property type="nucleotide sequence ID" value="XM_035453403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KCM7"/>
    <dbReference type="GeneID" id="100756579"/>
    <dbReference type="KEGG" id="cge:100756579"/>
    <dbReference type="CTD" id="6443"/>
    <dbReference type="OrthoDB" id="5843723at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027659">
        <property type="entry name" value="Sgcb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21142:SF2">
        <property type="entry name" value="BETA-SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21142">
        <property type="entry name" value="SARCOGLYCANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035309294.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32750" checksum="39F7B213EB8121B8" modified="2023-06-28" version="1">MREKAVERRNVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLLITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVEKNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNVELKAENSIILNGTVMVSPTRLPSSSSGDQSGSGDWVRYKLCMCADGTLFKVQVTGHNMGCQVSDNPCGNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KG54</accession>
    <name>A0A9J7KG54_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 120-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC113839055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035309690.1">
        <property type="nucleotide sequence ID" value="XM_035453799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KG54"/>
    <dbReference type="GeneID" id="113839055"/>
    <dbReference type="KEGG" id="cge:113839055"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002970">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="9">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035309690.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="26088" checksum="0FB863B40620F1D6" modified="2023-06-28" version="1">NVLSYEDVHINFTCKEWTLLDTSQKNIYKDVMLETYKNLNDIGYSWEAHTIEEHFPSSKRYERTHTGEKPYECNQCGKAFAQQAIFKCIKMHKKLHTGEKPYECNQCGKAFSQHSNLVTHKRTHTGEKPYECNQCNKAFSRLIHLQDHKRTHTGEKPYECNQCGKAFAQHSNLQVHKKLHTGEKYLKKKMRPSHYRVFGWIFYHHTSNQLHNCVYFVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3GRI2</accession>
    <name>G3GRI2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gbeta5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transducin beta chain 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Gnb5</name>
        <name evidence="12" type="ORF">I79_000128</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation. Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition. Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a complex composed of RGS9 (isoform RGS9-1), GNB5 and RGS9BP; within this complex, the presence of GNB5 stabilizes both itself and RGS9 and increases RGS9 GTPase-activating protein (GAP) activity. Interacts with RGS7, forming the RGS7-GNB5 complex; within this complex, the presence of GNB5 increases RGS7 GTPase-activating protein (GAP) activity. Interacts with GPR158; promotes the GTPase activator activity of the RGS7-GNB5 complex in absence of glycine, in contrast GTPase activator activity of the RGS7-GNB5 complex is inhibited in presence of glycine. Interacts with RGS6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000003">
        <property type="protein sequence ID" value="EGV99858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007644087.1">
        <property type="nucleotide sequence ID" value="XM_007645897.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266946.1">
        <property type="nucleotide sequence ID" value="XM_027411145.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GRI2"/>
    <dbReference type="SMR" id="G3GRI2"/>
    <dbReference type="STRING" id="10029.G3GRI2"/>
    <dbReference type="PaxDb" id="10029-XP_007620594.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014953.1">
        <property type="protein sequence ID" value="ENSCGRP00001010728.1"/>
        <property type="gene ID" value="ENSCGRG00001012527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764899"/>
    <dbReference type="KEGG" id="cge:100764899"/>
    <dbReference type="CTD" id="10681"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214413"/>
    <dbReference type="OMA" id="LDNKCTI"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV99858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027266946.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38732" checksum="30FCF51C125A024D" modified="2011-11-16" version="1">MATDGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYA2</accession>
    <name>G3GYA2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="17">1.3.8.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35 38" type="primary">Acadvl</name>
        <name evidence="34" type="ORF">I79_002775</name>
    </gene>
    <organism evidence="34 36">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="37" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
            <tissue evidence="38">Liver</tissue>
        </source>
    </reference>
    <reference evidence="35" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:19181"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.8.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:19182"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 28">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Homodimerizes after import into the mitochondrion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 28">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.9" evidence="17"/>
    <dbReference type="EMBL" id="JH000064">
        <property type="protein sequence ID" value="EGV93918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497242.1">
        <property type="nucleotide sequence ID" value="XM_003497194.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282764.1">
        <property type="nucleotide sequence ID" value="XM_027426963.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYA2"/>
    <dbReference type="STRING" id="10029.G3GYA2"/>
    <dbReference type="PaxDb" id="10029-XP_007625166.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015190.1">
        <property type="protein sequence ID" value="ENSCGRP00001010961.1"/>
        <property type="gene ID" value="ENSCGRG00001012717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767527"/>
    <dbReference type="KEGG" id="cge:100767527"/>
    <dbReference type="CTD" id="37"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158535"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004466">
        <property type="term" value="F:long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017099">
        <property type="term" value="F:very-long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046322">
        <property type="term" value="P:negative regulation of fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090181">
        <property type="term" value="P:regulation of cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001659">
        <property type="term" value="P:temperature homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01161">
        <property type="entry name" value="VLCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000017">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF11">
        <property type="entry name" value="VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 28" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 28" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="32">
        <location>
            <begin position="103"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="31">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="30">
        <location>
            <begin position="324"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="33">
        <location>
            <begin position="524"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="EGV93918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="RefSeq" id="XP_027282764.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="70394" checksum="644FFE4222A979B3" modified="2011-11-16" version="1">MQSARITPSVGRQLLRLGARSSRPTVLLGQHRPTSAQRLYASEAVQDKPDTLSSDASTKEKTAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVGPVGRFFEEVNDPAKNDSLEQVEEKTLQGLKELGAFGLQVPSELGGLGLCNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPKVASGQAVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGTKIWISNGGIADIFTVFAKTPIKDAATGAVKDKITAFVVERGFGGVTHGLPEKKMGIKASNTAEVYFDGVKVPSENVLGEVGSGFKVAVNILNNGRFGMAATLAGTMKAIIAKAVDHATNRTQFGDKIYNFGMIQEKLARMAILQYVTESMAYMLSANMDRGFTDFQIEAAISKIFGSEAAWRVTDECIQILGGMGFMKEPGVERVLRDTRIFRIFEGTNDILRLFVALQGCMDKGKELTGLGNALKNPLGNVGLLIGEAGKQLRRRTGLGSGLSLSGVVHPELSHSGELTVQALEQFATVVEAKLMKHKKGIVNEQFLLHRLADGAIDLYAMVVVLSRASRSLSEGHPEAQHEKMLCDSWCIEAAARIRENMANLQSNPQQQQLFRNFKSISKAMVDSGGVVTSNPLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYM8</accession>
    <name>G3GYM8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Fatty-acid amide hydrolase 1</fullName>
            <ecNumber evidence="3">3.5.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="37">Anandamide amidohydrolase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="35">Fatty acid ester hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="36">Oleamide hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="43 46" type="primary">Faah</name>
        <name evidence="42" type="ORF">I79_002933</name>
    </gene>
    <organism evidence="42 44">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="44" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="44">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="42" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="45" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="45">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="45" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="45">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="46" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="46">17A/GY</strain>
            <tissue evidence="46">Liver</tissue>
        </source>
    </reference>
    <reference evidence="43" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63120"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32426"/>
            <dbReference type="ChEBI" id="CHEBI:146167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63121"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63004"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:77220"/>
            <dbReference type="ChEBI" id="CHEBI:146165"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:63005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63000"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:77223"/>
            <dbReference type="ChEBI" id="CHEBI:146164"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:63001"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63028"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32392"/>
            <dbReference type="ChEBI" id="CHEBI:146166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:63029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:137830"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:63017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63008"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32375"/>
            <dbReference type="ChEBI" id="CHEBI:146168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:63009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:62996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:71589"/>
            <dbReference type="ChEBI" id="CHEBI:146163"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:62997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:26506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:116314"/>
            <dbReference type="EC" id="3.5.1.99"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:26507"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:133992"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:51318"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:82984"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:63021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)-octadecatrienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:62976"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32387"/>
            <dbReference type="ChEBI" id="CHEBI:142684"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:62977"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = methanol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63052"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:78033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:63053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:26133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(15Z-tetracosenoyl)-ethanolamine + H2O = (15Z)-tetracosenoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32392"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:146187"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>N-(15Z-tetracosenoyl)-taurine + H2O = (15Z)-tetracosenoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:63160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32392"/>
            <dbReference type="ChEBI" id="CHEBI:146198"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:63161"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:64108"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:59002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:64109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:64116"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:149697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate</text>
            <dbReference type="Rhea" id="RHEA:26136"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="3.5.1.99"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:26137"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-(9Z-hexadecenoyl) ethanolamine + H2O = (9Z)-hexadecenoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:35563"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:71465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:35564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(9Z-octadecenoyl) ethanolamine + H2O = ethanolamine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:45060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:45061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N-(9Z-octadecenoyl)-taurine + H2O = taurine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:63148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:146191"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:63149"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N-docosanoyl-ethanolamine + H2O = docosanoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:23858"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:146186"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:63129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N-docosanoyl-taurine + H2O = docosanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:63156"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:23858"/>
            <dbReference type="ChEBI" id="CHEBI:146196"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:63157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-octadecanoyl ethanolamine + H2O = octadecanoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:85299"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:63125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-tetracosanoyl-taurine + H2O = tetracosanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:63140"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:132049"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:63141"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N-tricosanoyl-taurine + H2O = tricosanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:63164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:79007"/>
            <dbReference type="ChEBI" id="CHEBI:146197"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:63165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tetradecamide + H2O = tetradecanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:62992"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:137125"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:62993"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.99" evidence="3"/>
    <dbReference type="EMBL" id="JH000068">
        <property type="protein sequence ID" value="EGV94571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497404.1">
        <property type="nucleotide sequence ID" value="XM_003497356.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258324.1">
        <property type="nucleotide sequence ID" value="XM_027402523.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYM8"/>
    <dbReference type="STRING" id="10029.G3GYM8"/>
    <dbReference type="GlyGen" id="G3GYM8">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001026750.1">
        <property type="protein sequence ID" value="ENSCGRP00001022505.1"/>
        <property type="gene ID" value="ENSCGRG00001021029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771171"/>
    <dbReference type="KEGG" id="cge:100771171"/>
    <dbReference type="CTD" id="2166"/>
    <dbReference type="GeneTree" id="ENSGT00940000161237"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150036">
        <property type="term" value="P:regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000001">
        <property type="entry name" value="Fatty-acid amide hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF3">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 42 46" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="40" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="45" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="40" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="40" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="40">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="41">
        <location>
            <begin position="96"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="38">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="38">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="38">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00052709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00052818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00052857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00052906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00073178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00077111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00077157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00077216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="EMBL" id="EGV94571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="RefSeq" id="XP_027258324.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="63328" checksum="9BB2494011263F00" modified="2011-11-16" version="1">MVLHQVWTALSGVSGIALACCLLAAAAVLRWAGRRTARRAAARARQRQRAGLETMDKAVQRFRLQNPDLDSEALLALPLPQLVQKLDSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTDCETHLAQAPRQGLLYGIPVSLKECFSYKGQDSTLGLSLNEGVPSECDSVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTLNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGGRLSKSGVKGCVYGQTAVQLSVGPMARDVESLALCLRALLCEDLFRLDPTIPPLPFREEVYTSSRPLRVGYYETDNYTMPTPAMRRAVLETKRSLEAAGHTLVPFLPNNIPYALEVLTTGGLFSDGGHTFLQNFKGDFVDPCLGELILILKLPRWFKSLLSFLLKPLYPRLAAFLRSMQPRSARKLWELQHEIEVYRNSVIDQWKAMNLDVLLTPMLGPALDLNAPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYRGYFGDIWDIILKKAMKKSVGLPVAVQCVALPWQEEMCLRFMREVERLMTPEKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYQ3</accession>
    <name>G3GYQ3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dual-specificity kinase</fullName>
            <ecNumber evidence="4">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Tesk2</name>
        <name evidence="21" type="ORF">I79_002958</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="4"/>
    <dbReference type="EMBL" id="JH000068">
        <property type="protein sequence ID" value="EGV94596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497424.1">
        <property type="nucleotide sequence ID" value="XM_003497376.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258376.1">
        <property type="nucleotide sequence ID" value="XM_027402575.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYQ3"/>
    <dbReference type="STRING" id="10029.G3GYQ3"/>
    <dbReference type="PaxDb" id="10029-XP_007620238.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032422.1">
        <property type="protein sequence ID" value="ENSCGRP00001028174.1"/>
        <property type="gene ID" value="ENSCGRG00001024966.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751809"/>
    <dbReference type="KEGG" id="cge:100751809"/>
    <dbReference type="CTD" id="10420"/>
    <dbReference type="eggNOG" id="ENOG502QTCP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158765"/>
    <dbReference type="OMA" id="REAWPFR"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14155">
        <property type="entry name" value="PKc_TESK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000202">
        <property type="entry name" value="Dual specificity testis-specific protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000134">
        <property type="entry name" value="Dual specificity testis-specific protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF6">
        <property type="entry name" value="DUAL SPECIFICITY TESTIS-SPECIFIC PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 21 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="58"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="515"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV94596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001028174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027258376.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="63654" checksum="8DCEFEF01222CA77" modified="2011-11-16" version="1">MDRSKRNSIAGFPPRVERLEEFEGGGGGDGNTSQVGRVSSSSYRAIISAFSRLTSLDDFTREKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANLLKEMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSTLYLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASTGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPEFLQLTFNCCNMDPKLRPSFEEIGKILEEIMSRLQEEELERDRKMQPTAKGLLEKVPGGKRLSSLDDKIPHKSPRPRRTIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAIRTPKVNPFSARQDLKGGKIKFFDLPSKSVISLVFDLDAPEPGTTPLADCQEPLAMSSRRWRSLPGSPEFLRQACPFVGGEESLSDGPPPRLSSRLKYGVREIPPFRASALPAASVHEAMDCSNPQEENGFGPRPKGTSPCVETASEEMEVEERPQMTPVHFSVSGISLQTQGEQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3H3N8</accession>
    <name>G3H3N8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WW domain-containing adapter protein with coiled-coil</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">Wac</name>
        <name evidence="12" type="ORF">I79_004867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16">17A/GY</strain>
            <tissue evidence="15 16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A. Interacts (via WW domain) with RNA polymerase II. Interacts with MTOR and other components of the MTOR pathway including RPTOR, RUVBL1, RUVBL2, TTI1 and TTI2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000129">
        <property type="protein sequence ID" value="EGW05176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498949.1">
        <property type="nucleotide sequence ID" value="XM_003498901.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261287.1">
        <property type="nucleotide sequence ID" value="XM_027405486.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261288.1">
        <property type="nucleotide sequence ID" value="XM_027405487.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H3N8"/>
    <dbReference type="STRING" id="10029.G3H3N8"/>
    <dbReference type="GlyGen" id="G3H3N8">
        <property type="glycosylation" value="2 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007634577.1"/>
    <dbReference type="GeneID" id="100770036"/>
    <dbReference type="CTD" id="51322"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H3N8"/>
    <dbReference type="OrthoDB" id="10072039at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000020">
        <property type="entry name" value="WW domain-containing adapter protein with coiled-coil isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGW05176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027261287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027261288.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="65405" checksum="6EF98BBAE2231212" modified="2011-11-16" version="1">MRDAADPSPPNKMLRRSDSPENKYSDSTGHNKAKNVHTQRVREREGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKLAVNSFPKDRDYRREVMQATATSGFTSGMEDKHSSDASSLLPQNILSQTSRHNDKDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTASVPAQKTERKESAPGDKSVSHSCTTPSTSSASGMNPTSAPPTSASTVPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATPQPVTADKQQGHEPVSPRSLQRLSSQRSPSPGPNHTSSSNASNATVVPQNTSARPACSLTPTLAAHFNDNLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3H6Y2</accession>
    <name>G3H6Y2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9 12">Syntaphilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Snph</name>
        <name evidence="9" type="ORF">I79_006106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000183">
        <property type="protein sequence ID" value="EGW06861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016829921.1">
        <property type="nucleotide sequence ID" value="XM_016974432.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277342.1">
        <property type="nucleotide sequence ID" value="XM_027421541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H6Y2"/>
    <dbReference type="STRING" id="10029.G3H6Y2"/>
    <dbReference type="PaxDb" id="10029-XP_007624777.1"/>
    <dbReference type="GeneID" id="100762714"/>
    <dbReference type="CTD" id="9751"/>
    <dbReference type="eggNOG" id="ENOG502QUYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H6Y2"/>
    <dbReference type="OrthoDB" id="5807119at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028197">
        <property type="entry name" value="Syntaphilin/Syntabulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16208">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN/SYNTAPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16208:SF1">
        <property type="entry name" value="SYNTAPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15290">
        <property type="entry name" value="Syntaphilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW06861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027277342.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="53239" checksum="092C9278B91A522C" modified="2011-11-16" version="1">MAMSLPGSRRASAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSCKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGIAKEEGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSSTSAEDGADSGFVAADDTLSRTDALEASSLLSSGVDCGLEEASLHSSFNLGPRFPASNTYEKLLCGMEAGVQASCMQERAIQTDFVQYQPDLDTILEKVGQAQVCGTVPKDRHSALDPHLSGPRDPNSAVVVTVSDEPEAPESITCGPATHQPASNSNPGLPVSVVCPVEEEEEAAATEKQPKSYWSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRRISCRSLSQPSSSAADGSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3H701</accession>
    <name>G3H701_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Synapse differentiation-inducing gene protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Dispanin subfamily C member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Transmembrane protein 90B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 29" type="primary">Syndig1</name>
        <name evidence="24" type="ORF">H671_6g15498</name>
        <name evidence="23" type="ORF">I79_006125</name>
    </gene>
    <organism evidence="23 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with GRIA1 and GRIA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Early endosome membrane</location>
            <topology evidence="17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic density membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000183">
        <property type="protein sequence ID" value="EGW06880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE680641">
        <property type="protein sequence ID" value="ERE71788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302022.1">
        <property type="nucleotide sequence ID" value="XM_035446131.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310104.1">
        <property type="nucleotide sequence ID" value="XM_035454213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H701"/>
    <dbReference type="STRING" id="10029.G3H701"/>
    <dbReference type="GlyGen" id="G3H701">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007624796.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024277.1">
        <property type="protein sequence ID" value="ENSCGRP00001020033.1"/>
        <property type="gene ID" value="ENSCGRG00001019306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113836327"/>
    <dbReference type="KEGG" id="cge:113836327"/>
    <dbReference type="CTD" id="79953"/>
    <dbReference type="eggNOG" id="ENOG502QQXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183147"/>
    <dbReference type="OMA" id="SWGDGMA"/>
    <dbReference type="OrthoDB" id="8440917at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035254">
        <property type="term" value="F:glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097091">
        <property type="term" value="P:synaptic vesicle clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14768:SF3">
        <property type="entry name" value="SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14768">
        <property type="entry name" value="UPF0338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGW06880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ERE71788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_035302022.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28562" checksum="C82941B448EDF75F" modified="2011-11-16" version="1">MDGIIEQKSVLVHSKISDAGKRNGLINTRNFMAESRDGLVSVYPAPQYQSHRLVASATPSSLEGGRSEPVQQLLDPNTLQQSVESHYRPNIILYSDGVLRSWGDGMATDCCETTFIEDRSPTKDSLEYPDGKFIDLSADDIKIHTLSYDVEEEEELQELESDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHETNKAVAKGDFHQASTSSRRALFLAVLSITIGTGIYVGVAVALIAYLSKNNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3H8K8</accession>
    <name>G3H8K8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase MARCHF7</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Membrane-associated RING finger protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Membrane-associated RING-CH protein VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase MARCHF7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 24" type="primary">Marchf7</name>
        <name evidence="20" type="ORF">I79_006711</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23 24">17A/GY</strain>
            <tissue evidence="23 24">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JH000213">
        <property type="protein sequence ID" value="EGW01585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639381.1">
        <property type="nucleotide sequence ID" value="XM_007641191.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276162.1">
        <property type="nucleotide sequence ID" value="XM_027420361.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302021.1">
        <property type="nucleotide sequence ID" value="XM_035446130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H8K8"/>
    <dbReference type="STRING" id="10029.G3H8K8"/>
    <dbReference type="PaxDb" id="10029-XP_007621971.1"/>
    <dbReference type="GeneID" id="100769757"/>
    <dbReference type="KEGG" id="cge:100769757"/>
    <dbReference type="CTD" id="64844"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H8K8"/>
    <dbReference type="OMA" id="RMMSGNR"/>
    <dbReference type="OrthoDB" id="2154780at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="term" value="F:ubiquitin binding"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16812">
        <property type="entry name" value="RING_CH-C4HC3_MARCH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000108">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR052297">
        <property type="entry name" value="RING-CH-type_E3_ubiq-ligase"/>
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    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="19">
        <location>
            <begin position="544"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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        </location>
    </feature>
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    </feature>
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        </location>
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            <end position="427"/>
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            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="683"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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            <begin position="61"/>
            <end position="83"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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            <end position="127"/>
        </location>
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            <end position="184"/>
        </location>
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        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
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            <begin position="215"/>
            <end position="232"/>
        </location>
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            <begin position="233"/>
            <end position="249"/>
        </location>
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            <begin position="684"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004906"/>
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            <dbReference type="ARBA" id="ARBA00012483"/>
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    </evidence>
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    <evidence type="ECO:0000256" key="7">
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022990"/>
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            <dbReference type="ARBA" id="ARBA00069013"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00084030"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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            <dbReference type="RefSeq" id="XP_027276162.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035302021.1"/>
        </source>
    </evidence>
    <sequence length="704" mass="77808" checksum="EB1580689F853DFE" modified="2011-11-16" version="1">MESKPSRIPRRISVQPSGSLSARMVSGNRGASLNDSYHSRDSSFRLDSEYQSASASASASPFQSTWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTSTSAGRNIGSGLNTVSDSSWRHSQVPRSSSMVLGSFGTDLIRERRDLERRADSSISNLMDYNHRSGDFTTSSYVQERVPSSYSQGARPKENSMSTLQLNSSSTNHQLPSEHQTVSSSRDSSRNSFRSHFSPRQSQSFRNSSHPTFSYLSSRDETPIISNSERVGSSRRPFQESSDNDGRRSTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSENYISPRTLTSQSRSSGASSSEVNDGRASEASQGFRFLRRRWGLSSLSQNHSSEPDAENFNQESEGRSTGPWLSSSLRNRCTPLFSRRRREGRDESSRISPSDVPPRSHIFRRESNEVVHLEAQSDPLGAAANRPQASGASSSAAGGSPPDLPQGGRSTGIAGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNAADGKSDKTKSAPSRDPEKLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTIEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3HC09</accession>
    <name>G3HC09_CRIGR</name>
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        <submittedName>
            <fullName evidence="8">Solute carrier family 39 (zinc transporter), member 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6 12 13 14">Zinc transporter ZIP1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Zinc transporter ZIP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 12 13 14 15" type="primary">Slc39a1</name>
        <name evidence="7" type="ORF">H671_1g1479</name>
        <name evidence="6" type="ORF">I79_008050</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13 14">17A/GY</strain>
            <tissue evidence="12 13 14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000275">
        <property type="protein sequence ID" value="EGV98131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE663882">
        <property type="protein sequence ID" value="ERE90670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003501677.1">
        <property type="nucleotide sequence ID" value="XM_003501629.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640480.1">
        <property type="nucleotide sequence ID" value="XM_007642290.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640481.1">
        <property type="nucleotide sequence ID" value="XM_007642291.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249136.1">
        <property type="nucleotide sequence ID" value="XM_027393335.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249137.1">
        <property type="nucleotide sequence ID" value="XM_027393336.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249138.1">
        <property type="nucleotide sequence ID" value="XM_027393337.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249139.1">
        <property type="nucleotide sequence ID" value="XM_027393338.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HC09"/>
    <dbReference type="STRING" id="10029.G3HC09"/>
    <dbReference type="PaxDb" id="10029-XP_007612676.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013882.1">
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        <property type="entry name" value="ZINC TRANSPORTER ZIP1"/>
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        <property type="entry name" value="Zip"/>
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            <dbReference type="EMBL" id="EGV98131.1"/>
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    <sequence length="324" mass="34357" checksum="474E2D7CCB44B413" modified="2011-11-16" version="1">MGPWGEPELLVWRPEAIASEPSVPVGLEVKLGALVLLLLLTLVCSLVPVCVLRRPGASHEASASGQKILSLVSCFAGGVFLATCLLDLLPDYLAAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSSPPHPEETRALLGSVNGGPQHWHDGPGIPQASGTPAAPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLFHKGILAVSLSLRLLQSHLRVQVVAGCGILFSCMTPLGIGLGTALSESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
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        <name evidence="17 20" type="primary">Ltb4r</name>
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    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSCGRG00001012531.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:inflammatory response"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007204">
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="Formyl_rcpt-rel"/>
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    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003981">
        <property type="entry name" value="Leukotriene_B4_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003983">
        <property type="entry name" value="Leukotriene_B4_typ-1_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225">
        <property type="entry name" value="CHEMOTACTIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01477">
        <property type="entry name" value="LTB1RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01476">
        <property type="entry name" value="LTBRECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
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            <end position="45"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="242"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="289"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="36"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="326"/>
            <end position="348"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035308989.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37773" checksum="7F79B6F4A54E4C81" modified="2011-11-16" version="1">MAPNITSPAAASSPGGMSLSLPIVLLSVALAVGLPGNSFVVWSILRRMQKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFKVTGCRLCHYVCGVSMYASVLLITIMSLDRSLAVARPFVSQKVRTKRVALWVLASIWLVSFLLATPVIAYRTVKRNNRTLTLVCQPDYPSDGHRAFHLLFETITGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHLVNLVEAGRALAGWDQDDSAGKRLKLARYVLIALAFLSSSVNPVLYACAGGGLLRSAGFGFVVKLLEATASEVSSTRRGGTLCQTQKSIPACPEPGPTDSFMTSSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3HLG4</accession>
    <name>G3HLG4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 16">Olfactory receptor 1G1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100772855</name>
        <name evidence="13" type="ORF">I79_011552</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000490">
        <property type="protein sequence ID" value="EGW04596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643210.1">
        <property type="nucleotide sequence ID" value="XM_007645020.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279412.1">
        <property type="nucleotide sequence ID" value="XM_027423611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HLG4"/>
    <dbReference type="STRING" id="10029.G3HLG4"/>
    <dbReference type="PaxDb" id="10029-XP_007613066.1"/>
    <dbReference type="GeneID" id="100772855"/>
    <dbReference type="KEGG" id="cge:100772855"/>
    <dbReference type="eggNOG" id="ENOG502TDCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HLG4"/>
    <dbReference type="OrthoDB" id="5967130at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15918">
        <property type="entry name" value="7tmA_OR1_7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="27"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW04596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027279412.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32824" checksum="A2BBA591CEB60E3B" modified="2011-11-16" version="1">MGFSEHPEQQPLLFTLFLGMYLVTLFGNVLIILAIGSDEHLHTPMYFFLANLSFIDTCFTSTIVPKVLTNIQTQHHTISHAGCLLQMYFFMVLAMLDDFLLAVMAYDRYVAICLPLHYITIMCPQRCLFLVVTSWLCSNLLALSLTLQMAQASFCASHSIPHFFCDLLPLLKLSCSDTQTFQLMMFAEAAVSGVVPLTCVLVSYAHITHTILKIPSTEGKHKVFSTCGSHLTVVTLFYGTVFLVYFQPSSSYSADTGIVASIVYTMVTPMLNPFIYSLRNKDMKGALWRLVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3HUZ6</accession>
    <name>G3HUZ6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="13">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Pif1</name>
        <name evidence="13" type="synonym">PIF1</name>
        <name evidence="18" type="ORF">I79_014769</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Monomer. Interacts with telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="13"/>
    <dbReference type="EMBL" id="JH000758">
        <property type="protein sequence ID" value="EGW10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267122.1">
        <property type="nucleotide sequence ID" value="XM_027411321.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314810.1">
        <property type="nucleotide sequence ID" value="XM_035458919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HUZ6"/>
    <dbReference type="SMR" id="G3HUZ6"/>
    <dbReference type="STRING" id="10029.G3HUZ6"/>
    <dbReference type="PaxDb" id="10029-XP_007608119.1"/>
    <dbReference type="GeneID" id="100755109"/>
    <dbReference type="KEGG" id="cge:100755109"/>
    <dbReference type="CTD" id="80119"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HUZ6"/>
    <dbReference type="OrthoDB" id="272985at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160225">
        <property type="term" value="F:G-quadruplex unwinding activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000805">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003367">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="17">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="15">
        <location>
            <begin position="202"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="16">
        <location>
            <begin position="454"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="13">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="224"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGW10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027267122.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="69550" checksum="26AE2404EC1955F9" modified="2011-11-16" version="1">MLSSTQAATGECEDAELRCRVAVEELSPGGQPRKRQALRTAELSLGRNERRELMLRLQAPGPAGRPRCFPLRAARLFTRFAAAGRSTLRLPVDDVPRAGSVQLLLSDCPPERLRRFLRTLRLKLAAAPGPGPASARAQLLGPRPRDFVTISPVQPEELRRAVATRAPDSAPEKRPTESKPSTEAPRWPLPVKKLSMHSTKPKLSEEQAAVLRLVLKGQSIFFTGSAGTGKSYLLKQILGSLPPTGTVATASTGVAACHIGGTTLHAFAGIGSGQAPLAQCVALAHRPGVRQGWLNCQRLVIDEISMVEADLFDKLEAVARAVRQQKKPFGGIQLIICGDFLQLPPVTKGSQHPRFCFQAKSWRKCVPVTLELTEVWRQADPTFISLLQAVRLGRCSDEVTHQLRATAAHKVGRDGIVATRLCTHQDDVALTNEKRLKELPGEVHSFEAIDSDPELARTLDAQCPVSRVLQLKLGAQVMLVKNLSLSRGLVNGARGVVVGFESEGRGLPQVRFLCGVTEVIRTDRWTVQVTGGQFLSRQQLPLQLAWAMSIHKSQGMSLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPTVVRCDSRVLHFYATLRQGRGLSLESQDDEETNSDLENMDPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3I434</accession>
    <name>G3I434_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="11">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Ssu72</name>
        <name evidence="12" type="ORF">I79_018214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with GTF2B (via C-terminus); this interaction is inhibited by SYMPK. Interacts with RB1. Interacts with CD226. Interacts with SYMPK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="EMBL" id="JH001219">
        <property type="protein sequence ID" value="EGW07795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510025.1">
        <property type="nucleotide sequence ID" value="XM_003509977.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254365.1">
        <property type="nucleotide sequence ID" value="XM_027398564.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I434"/>
    <dbReference type="STRING" id="10029.G3I434"/>
    <dbReference type="PaxDb" id="10029-XP_007606858.1"/>
    <dbReference type="GeneID" id="100772289"/>
    <dbReference type="KEGG" id="cge:100772289"/>
    <dbReference type="CTD" id="29101"/>
    <dbReference type="eggNOG" id="KOG2424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I434"/>
    <dbReference type="OMA" id="PNCYEFG"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000066">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase SSU72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGW07795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027254365.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22530" checksum="2F3B3157A239216D" modified="2011-11-16" version="1">MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICDLCQCIQHTEDMENEIDELLQEFEEKSGRAFLHTVCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3I707</accession>
    <name>G3I707_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G protein-coupled receptor 139</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Probable G-protein coupled receptor 139</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Putative G-protein coupled receptor 139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Gpr139</name>
        <name evidence="11" type="ORF">I79_019288</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH001404">
        <property type="protein sequence ID" value="EGV92833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510923.1">
        <property type="nucleotide sequence ID" value="XM_003510875.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266149.1">
        <property type="nucleotide sequence ID" value="XM_027410348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I707"/>
    <dbReference type="STRING" id="10029.G3I707"/>
    <dbReference type="PaxDb" id="10029-XP_007632860.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027061.1">
        <property type="protein sequence ID" value="ENSCGRP00001022816.1"/>
        <property type="gene ID" value="ENSCGRG00001021239.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766538"/>
    <dbReference type="KEGG" id="cge:100766538"/>
    <dbReference type="CTD" id="124274"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159473"/>
    <dbReference type="OMA" id="WLVHIVS"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15919">
        <property type="entry name" value="7tmA_GPR139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000126">
        <property type="entry name" value="Probable G-protein coupled receptor 139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037486">
        <property type="entry name" value="GPR139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052477">
        <property type="entry name" value="Orphan_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 139-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV92833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027266149.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39659" checksum="677B59D88059608E" modified="2011-11-16" version="1">MEHTHAHLAANSSACGLGFVPVVYYSFLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILSVQMPPIPDKIIEVLEFSSIHTSIWITVPLTVDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYTSTSMHHVLVWIHCFTVYLVPCSIFFILNSIIVYKLRRKSSFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGSPIQNPWLVHIMLDVANMLALLNTAINFFLYCFISKRFRTMAAATLKALFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKHGKPIKVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3IGW8</accession>
    <name>G3IGW8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 16">AN1-type zinc finger protein 5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Zinc finger, AN1-type domain 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">Zfand5</name>
        <name evidence="11" type="ORF">H671_3g9666</name>
        <name evidence="10" type="ORF">I79_023045</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH002652">
        <property type="protein sequence ID" value="EGW12637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE672369">
        <property type="protein sequence ID" value="ERE79361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513993.1">
        <property type="nucleotide sequence ID" value="XM_003513945.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262342.1">
        <property type="nucleotide sequence ID" value="XM_027406541.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IGW8"/>
    <dbReference type="STRING" id="10029.G3IGW8"/>
    <dbReference type="PaxDb" id="10029-XP_007620405.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015676.1">
        <property type="protein sequence ID" value="ENSCGRP00001011444.1"/>
        <property type="gene ID" value="ENSCGRG00001013083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760152"/>
    <dbReference type="KEGG" id="cge:100760152"/>
    <dbReference type="CTD" id="7763"/>
    <dbReference type="eggNOG" id="KOG3173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156165"/>
    <dbReference type="OMA" id="VLCENNC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060324">
        <property type="term" value="P:face development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048705">
        <property type="term" value="P:skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048745">
        <property type="term" value="P:smooth muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001944">
        <property type="term" value="P:vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4770:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF26">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGW12637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ERE79361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027262342.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23072" checksum="116C51FB00B6DD52" modified="2011-11-16" version="1">MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADASLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSASQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3IHB0</accession>
    <name>G3IHB0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">14 kDa phosphohistidine phosphatase</fullName>
            <ecNumber evidence="5">3.9.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohistidine phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein histidine phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Phpt1</name>
        <name evidence="16" type="ORF">I79_023198</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits phosphohistidine phosphatase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(pros)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47964"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="3.9.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(tele)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47960"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:10719"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="3.9.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the janus family.</text>
    </comment>
    <dbReference type="EC" id="3.9.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JH002744">
        <property type="protein sequence ID" value="EGW14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514114.1">
        <property type="nucleotide sequence ID" value="XM_003514066.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278705.1">
        <property type="nucleotide sequence ID" value="XM_027422904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IHB0"/>
    <dbReference type="STRING" id="10029.G3IHB0"/>
    <dbReference type="PaxDb" id="10029-XP_007637212.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010966.1">
        <property type="protein sequence ID" value="ENSCGRP00001006972.1"/>
        <property type="gene ID" value="ENSCGRG00001009448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761523"/>
    <dbReference type="KEGG" id="cge:100761523"/>
    <dbReference type="CTD" id="29085"/>
    <dbReference type="eggNOG" id="ENOG502S4DR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VRGYSWA"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061851">
        <property type="term" value="C:leading edge of lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097581">
        <property type="term" value="P:lamellipodium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050860">
        <property type="term" value="P:negative regulation of T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000147">
        <property type="term" value="P:positive regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.20.20:FF:000001">
        <property type="entry name" value="14 kDa phosphohistidine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258:SF10">
        <property type="entry name" value="14 KDA PHOSPHOHISTIDINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258">
        <property type="entry name" value="JANUS-A/JANUS-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027278705.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13956" checksum="70FA067406D6FBBE" modified="2011-11-16" version="1">MAADLAQIPDVDIDSDGVFKYVLIRVHLAPPSGDPTTECKEIVRGYKWAEYHADIYDKVSGELQKNGYDCECLGGGRISHQSQNRKIHVYGYSMGYGRAQHSVSTEKIKAMYPDYEVTWADDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I173</accession>
    <name>A0A061I173_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPI fold containing family A, member 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">BPI fold-containing family A member 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative short palate, lung and nasal epithelium carcinoma-associated protein 3 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">Bpifa3</name>
        <name evidence="3" type="ORF">H671_6g15981</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="KE680922">
        <property type="protein sequence ID" value="ERE71116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512068.1">
        <property type="nucleotide sequence ID" value="XM_003512020.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276752.1">
        <property type="nucleotide sequence ID" value="XM_027420951.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I173"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021728.1">
        <property type="protein sequence ID" value="ENSCGRP00001017484.1"/>
        <property type="gene ID" value="ENSCGRG00001017514.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754343"/>
    <dbReference type="KEGG" id="cge:100754343"/>
    <dbReference type="CTD" id="128861"/>
    <dbReference type="GeneTree" id="ENSGT01100000263546"/>
    <dbReference type="OMA" id="TNMQLDY"/>
    <dbReference type="OrthoDB" id="9534465at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032946">
        <property type="entry name" value="Bpifa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47736">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47736:SF1">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044538471" evidence="1">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ERE71116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027276752.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26825" checksum="4DA75BCEBDE3D59C" modified="2014-09-03" version="1">MHPLWRFLILLLGLLVLPSALLKEPWPGLTTAHKDGRSTLERIIAQGLLKHNAEGRIQSIRLLDRLNVSGMAAPGMVGWLIGGMNFKQQQEISINITNVQLYCDGIQMAFPKEWFSTNITLEFDVEFQLPFNSNIIKTHARMGLTAESWLEKDEFGRRELVMGRCHMEPGSEGASMSTEAVPPKMKHFLHNLRESLGKVIPNLVESQVCPLIGDILRQLDVKLLKGLVEQVAARNLGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IAE6</accession>
    <name>A0A061IAE6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phagosome assembly factor 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative UPF0183 protein C16orf70 like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">UPF0183 protein C16orf70 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Phaf1</name>
        <name evidence="6" type="synonym">C3H16orf70</name>
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    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE673570">
        <property type="protein sequence ID" value="ERE77188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003508583.1">
        <property type="nucleotide sequence ID" value="XM_003508535.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261591.1">
        <property type="nucleotide sequence ID" value="XM_027405790.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IAE6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007133.1">
        <property type="protein sequence ID" value="ENSCGRP00001004719.1"/>
        <property type="gene ID" value="ENSCGRG00001006064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758102"/>
    <dbReference type="KEGG" id="cge:100758102"/>
    <dbReference type="CTD" id="80262"/>
    <dbReference type="GeneTree" id="ENSGT00940000153528"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ERE77188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027261591.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47448" checksum="B3DDF3B6347AE150" modified="2014-09-03" version="1">MLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLLFDAFNQRLKVIEVYDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGLASLQIPHGATVKRMYIYSGNSLQDTKAPVMPLSCFLGNVYAESVDVLRDGTGPSGLRLRLLAAGCGPGVLADAKMRVFERSVYFGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPSPHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPGHYNFNIYHRCEFKIPLAVKKENAGGQTETCTTYSKWDNIQELLGHPVEKPVVLHRSSSPNNTNPFGSTFCFGLQRMIFEVMQNNHIASVTLYGPPRPGAHLRTAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ILK7</accession>
    <name>A0A061ILK7_CRIGR</name>
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        <recommendedName>
            <fullName evidence="5">Methylmalonyl-CoA mutase, mitochondrial</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methylmalonyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21 22 23" type="primary">Mmut</name>
        <name evidence="17" type="ORF">H671_1g3415</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:22889"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Interacts (the apoenzyme form) with MMAA; the interaction is GTP dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="4"/>
    <dbReference type="EMBL" id="KE666547">
        <property type="protein sequence ID" value="ERE87947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_007649469.1">
        <property type="nucleotide sequence ID" value="XM_007651279.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649470.1">
        <property type="nucleotide sequence ID" value="XM_007651280.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649471.1">
        <property type="nucleotide sequence ID" value="XM_007651281.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243274.1">
        <property type="nucleotide sequence ID" value="XM_027387473.2"/>
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    <dbReference type="RefSeq" id="XP_027243276.1">
        <property type="nucleotide sequence ID" value="XM_027387475.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243277.1">
        <property type="nucleotide sequence ID" value="XM_027387476.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061ILK7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024490.1">
        <property type="protein sequence ID" value="ENSCGRP00001020246.1"/>
        <property type="gene ID" value="ENSCGRG00001019456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765277"/>
    <dbReference type="KEGG" id="cge:100765277"/>
    <dbReference type="CTD" id="4594"/>
    <dbReference type="GeneTree" id="ENSGT00390000011892"/>
    <dbReference type="OMA" id="IQEETHI"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:modified amino acid binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:homocysteine metabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:post-embryonic development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
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    <dbReference type="CDD" id="cd03679">
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    <dbReference type="FunFam" id="3.20.20.240:FF:000002">
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        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058549">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006944">
        <property type="entry name" value="PRK09426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="B12-binding" evidence="16">
        <location>
            <begin position="612"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023703"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033108"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00046548"/>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="ERE87947.1"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027243276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027243277.1"/>
        </source>
    </evidence>
    <sequence length="748" mass="82885" checksum="D1993F02A07F033B" modified="2014-09-03" version="1">MLRAKNQLFLLSPHYLKQLKDTSASRWKRLLHQQQPLHPEWAVLAKKQLKGKNPEDLIWRTPEGISIKPLYSRADTMDLPEELPGVKPFTRGPYPTMYTYRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPILATFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAQHMPKFNSISISGYHMQEAGADAILELAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMESLTNDVYEAALKLINEVEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDSVEVLAIDNTSVRKKQIEKLKKIKSSRDQVLAQRSLEALTQCAATGDGNILALAVDAARARCTVGEITDALKKIFGEHKANDRMVSGAYRQEFGESKEITSAIKRVSKFMECEGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELTALGRPDILVMCGGVIPPQDYEFLYEAGVSNIFGPGTRIPKAAVQVLDDIEKCLAEKQQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IR65</accession>
    <name>A0A061IR65_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15 18 19 20">Zinc finger protein GLI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19 20 21 22 23 24" type="primary">Gli1</name>
        <name evidence="15" type="ORF">H671_1g1564</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19 20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19 20">17A/GY</strain>
            <tissue evidence="18 19 20">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KE663902">
        <property type="protein sequence ID" value="ERE90588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248013.1">
        <property type="nucleotide sequence ID" value="XM_027392212.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248014.1">
        <property type="nucleotide sequence ID" value="XM_027392213.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248015.1">
        <property type="nucleotide sequence ID" value="XM_027392214.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248016.1">
        <property type="nucleotide sequence ID" value="XM_027392215.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248018.1">
        <property type="nucleotide sequence ID" value="XM_027392217.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306804.1">
        <property type="nucleotide sequence ID" value="XM_035450913.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306805.1">
        <property type="nucleotide sequence ID" value="XM_035450914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IR65"/>
    <dbReference type="GeneID" id="100763229"/>
    <dbReference type="KEGG" id="cge:100763229"/>
    <dbReference type="CTD" id="2735"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048562">
        <property type="term" value="P:embryonic organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000068">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN GLI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="374"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="514"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="830"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ERE90588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027248013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027248014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027248015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027248016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027248018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035306804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035306805.1"/>
        </source>
    </evidence>
    <sequence length="1105" mass="117765" checksum="6385DE8774C98043" modified="2014-09-03" version="1">MFNSMTPPQANSYGEPCCLRPLPSQGVPSLGTEGFSGLPFCHQANFISGSQGYGSARETNGCSEGPLFPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPSYGVQPCVPQDSTRGAMMLHPQSRRPRQTCQKLKSELDMLVGKCPEEPLEGDMSSPNSTGTQDPLLGMLDGREDLEEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSLSTVEPKREREGGPIREESRLTVPEGAMKPQQSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCVAGTGLSTLHRLENLRLDQLHQLRPLGSRGLKLPSLTHAGTPVSRRLGPPGSLDHRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGVSSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGHLPVPSWRSRAEYPGYNPNAGVTRRASDPAGAADHPAPARVQRFKSLGCVHTPPSAATGRNFDPHLPTSVYSPQPPSITENVAMDTRGLQEEPEVGASVMGNGLNQYMGFPSADSLGYGGPEGAAAEPYEARGPGSLALGPGPLTSYGPSHCPQQVSYPDPTPETWSEFPSHSGMYPGTKAPTGAYIQCPRLEHYGQVQVKPEQGCLVGSNSTGLAPCLNAHPTEGSPGPQPSFSHYSQPPPPQYPQSGPYPRPPHDYLPSEHRPGLDFDSPSHSEGQLKAQLVCNYVQSQQELLWEGKGRGGLPNQELPYQSSKFLGGSQANQSPVKGPAAAYGSGFAPALASHKPGSFPAPSPCHETFTVGINRPSHRPAAVPPRLLPPLPSCYGPLKVGGANPSCGHPEVGRLGAGPALYPPPEGQVSNPLDSLDLDSTQLDFVAILDEAQGLSPPPSHEQGDSSKNTPPPSGTPNMAVGNMSVLLGSLPGETQFLNSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H8E1</accession>
    <name>A0A3L7H8E1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Atonal bHLH transcription factor 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Protein atonal homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Atoh1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027286042.1">
        <property type="nucleotide sequence ID" value="XM_027430241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H8E1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019546.1">
        <property type="protein sequence ID" value="ENSCGRP00001015305.1"/>
        <property type="gene ID" value="ENSCGRG00001015957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769461"/>
    <dbReference type="KEGG" id="cge:100769461"/>
    <dbReference type="CTD" id="474"/>
    <dbReference type="GeneTree" id="ENSGT00940000160064"/>
    <dbReference type="OrthoDB" id="6161578at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042668">
        <property type="term" value="P:auditory receptor cell fate determination"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042667">
        <property type="term" value="P:auditory receptor cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021953">
        <property type="term" value="P:central nervous system neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904036">
        <property type="term" value="P:negative regulation of epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014014">
        <property type="term" value="P:negative regulation of gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097402">
        <property type="term" value="P:neuroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045609">
        <property type="term" value="P:positive regulation of inner ear auditory receptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19713">
        <property type="entry name" value="bHLH_TS_ATOH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000025">
        <property type="entry name" value="protein atonal homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032661">
        <property type="entry name" value="ATOH1_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF82">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027286042.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="37759" checksum="ADC2AE446259D160" modified="2019-02-13" version="1">MSRLLHAEEWAEVKELGDHRHSQPHHLPQLPPQPPATLQARDHPVYPAELSLLDSTDPRAWLTPTLQGLCTARAAQYLLHSPELGASETAAPRDEADSQGELVRRSGCGGLSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSVGDQPPPPAASCKNDHHHLRAAATYEGGSSASAAAGAQSAQGGGPRPTPPGACRTRFSSPASAGAYSVQLDALHFPSFEDRALTAMMAQKDLSPSLPGSILQPVQEDSSKTSPRSHRSDGEFSPHSHYSDSDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HRK6</accession>
    <name>A0A3L7HRK6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine rich repeat containing 58</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 58 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Lrrc58</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027268505.1">
        <property type="nucleotide sequence ID" value="XM_027412704.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HRK6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014115.1">
        <property type="protein sequence ID" value="ENSCGRP00001009896.1"/>
        <property type="gene ID" value="ENSCGRG00001011907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768513"/>
    <dbReference type="KEGG" id="cge:100768513"/>
    <dbReference type="CTD" id="116064"/>
    <dbReference type="GeneTree" id="ENSGT00940000156556"/>
    <dbReference type="OrthoDB" id="1053178at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF13">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027268505.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40231" checksum="47E16FBC2CF18955" modified="2019-02-13" version="1">MEEAAIGDAELNWSRLSVSAETLESELEARAEERRGSREALQRLLLSYNRLTSLPRALGSGFPHLQLLDVSGNALTALGPELLTLSGLRTLLARNNRLGGPGSLPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQRLECLYLGGNFIKEIPPELANLPSLNYLVLCDNKIQSVPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRSISYTPYDLPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSATHSSTSQSESDSEDEASVAAHRMQKVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LE47</accession>
    <name>A0A8C2LE47_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Complement C1r subcomponent-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Complement component 1, r subcomponent-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">C1rl</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003496121.1">
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        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678479" evidence="14">
        <location>
            <begin position="46"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="41"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="244"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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    </evidence>
    <sequence length="486" mass="53597" checksum="70315CB454D8FA9C" modified="2022-01-19" version="1">MSGSRGRVPELETTCGALPPQAACLGKMCWLLFLWGTLHTCPTQASVLLAQQLPQQVTSPGYPEPYLKGQESHTDIEAPEGFVVRLVFQDFDIEPSPGCEGDSVTISTRGTDAIWLCGQHASSLESTPGHREFVSSGRSLRLTFRAHSPSQNKITHSHKGFLALYQAVAVNQPNGDSEAVTTPGADCPRIQNHCQDPYYEAKQTGTFNCPSLGTWKDRQDKEQVPQCVPVCGRPVIPIAQNPKTSGSSPAKLGNFPWQAFTSIYGRGGGALLGDRWILTAAHTIYPKDSVYLRKNKSVEVFLGHTDVDELLKLGNHPVRRVVVHPDYRQHESHNFNGDIALLELQHSVPLGPNLLPVCLPDNETLYHSGLWGYVSGFGVEMGWLTTKLKYSQLPVAPREACEAWLHQKQRTEVFSDNMFCAGDENQVNSVCQGDSGSVYVVWDNRTLHWVATGIVSWGIGCGKGYGFYTKVLSYVDWIKRVMDGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LEN6</accession>
    <name>A0A8C2LEN6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="4 19">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Trit1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA). TRIT1 is therefore required for selenoprotein expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19 20">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="4 19"/>
    <dbReference type="RefSeq" id="XP_016832432.1">
        <property type="nucleotide sequence ID" value="XM_016976943.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254974.1">
        <property type="nucleotide sequence ID" value="XM_027399173.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LEN6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002356.1">
        <property type="protein sequence ID" value="ENSCGRP00001001925.1"/>
        <property type="gene ID" value="ENSCGRG00001001894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773722"/>
    <dbReference type="KEGG" id="cge:100773722"/>
    <dbReference type="CTD" id="54802"/>
    <dbReference type="GeneTree" id="ENSGT00390000015214"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070900">
        <property type="term" value="P:mitochondrial tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001625">
        <property type="entry name" value="tRNA dimethylallyltransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.140:FF:000002">
        <property type="entry name" value="tRNA dimethylallyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 19" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger double-stranded RNA binding" evidence="22">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="425"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027254974.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52656" checksum="C9CFD46629E71DBE" modified="2022-01-19" version="1">MAAAAAARAVPVSSGFRGLRRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYKGLDIVTNKVSAQERRMCQHHMIGFVDPLVSSYTVVDFNNRATALIEDIFARDKIPIVVGGTNYYIESLLWKVLVNTRPQEMGTGKVVDRKAELEKEDGHELHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGISHSEFLHRQHAEEGGGPLGGPLKFPNPCILWLHADQRVLDERLDKRVDDMLAAGLLEELRDFHRRYNLKTVSENSQDYQHGIFQSIGFKEFHEYLITEGKCTPETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPSVPPVYGLEVSDVSKWEESVLEPALNIVQSFIQGHKPTATPMKMPYNEAENKRSHHMCDLCDRIIIGDREWAAHIKSKSHLHQLKKRRKLDSDAVPALRNQSSSPDCDPELKEGKSPVQQDQELKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LEY6</accession>
    <name>A0A8C2LEY6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">LOC100766423</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer with either MAGOH or MAGOHB. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. Component of the ALYREF/THOC4-EJC-RNA complex; in the complex interacts with EIF4A3 and MAGOH; these interactions are likely specific to RNA-bound EJC. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Part of a complex that contains the EJC core components CASC3, EIF4A3, MAGOH and RBM8A plus proteins involved in nonsense-mediated mRNA decay, such as UPF1, UPF2, UPF3A and UPF3B. Found in a post-splicing complex with NXF1, MAGOH, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Interacts with DDX39B, MAGOH, DPH1, UPF3B, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with IPO13; the interaction mediates the nuclear import of the MAGOH-RBM8A heterodimer. Identified in the spliceosome C complex. Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RBM8A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301717.1">
        <property type="nucleotide sequence ID" value="XM_035445826.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314523.1">
        <property type="nucleotide sequence ID" value="XM_035458632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LEY6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003645.1">
        <property type="protein sequence ID" value="ENSCGRP00001002678.1"/>
        <property type="gene ID" value="ENSCGRG00001003032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766423"/>
    <dbReference type="KEGG" id="cge:100766423"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000157">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 15" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035301717.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19923" checksum="902422B4DC03F93C" modified="2022-01-19" version="1">MADMLDLRAAGVKDFAIDENGDKSIHKLKGKAKKMKRRGFGSKEVSRARMREDYDSVEQDGNEPRTQPSVEGWILFVTGVQEEATEEDIHDKFAEYGEIKNIHLNLDRHIGYLKGYILVEYETYKEAQAAMEGLNGQYLMRQPISIDWCFVPGPPKGKRRCGRRGSRSPDPRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LF90</accession>
    <name>A0A8C2LF90_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15">Kell blood group</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Kel</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
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                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
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                <person name="Goesmann A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">17A/GY</strain>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_035457091.1"/>
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        <property type="protein sequence ID" value="ENSCGRP00001002284.1"/>
        <property type="gene ID" value="ENSCGRG00001002422.1"/>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
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        <property type="entry name" value="Neutral endopeptidase , domain2"/>
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        <location>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LI08</accession>
    <name>A0A8C2LI08_CRIGR</name>
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        <recommendedName>
            <fullName evidence="6">Prothymosin alpha</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8 11" type="primary">LOC103159629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with NUPR1; regulates apoptotic process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pro/parathymosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027264701.1">
        <property type="nucleotide sequence ID" value="XM_027408900.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LI08"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003760.1">
        <property type="protein sequence ID" value="ENSCGRP00001002746.1"/>
        <property type="gene ID" value="ENSCGRG00001003128.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004931">
        <property type="entry name" value="Pro/parathymosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22745">
        <property type="entry name" value="PROTHYMOSIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22745:SF0">
        <property type="entry name" value="PROTHYMOSIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03247">
        <property type="entry name" value="Prothymosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027264701.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12912" checksum="A87EF391FD7A42F4" modified="2022-01-19" version="1">MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAEAPTGKRVAEDDEDDDVDTKKQKTGEDNWTAERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LQB7</accession>
    <name>A0A8C2LQB7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fibrillarin-like 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">LOC100767429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027280642.1">
        <property type="nucleotide sequence ID" value="XM_027424841.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LQB7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011683.1">
        <property type="protein sequence ID" value="ENSCGRP00001007625.1"/>
        <property type="gene ID" value="ENSCGRG00001010028.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767429"/>
    <dbReference type="KEGG" id="cge:100767429"/>
    <dbReference type="GeneTree" id="ENSGT00550000074792"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062105">
        <property type="term" value="F:RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001835">
        <property type="term" value="P:blastocyst hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF6">
        <property type="entry name" value="RRNA_TRNA 2'-O-METHYLTRANSFERASE FIBRILLARIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027280642.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="33872" checksum="EC81D8AC7B3071B5" modified="2022-01-19" version="1">MKPAGGRGGWGWGGGKGGGKGGDSGSGGKGGFGARTRGFSGGGRGRGRGGGGGGDSRDRGGSGQRRGGQARNKSRRRKGITVSVEPHRHEGVFIYRGAEDALVTLNMVPGVSVYGEKRVTVVENGEKQEYRTWNPFRSKLAAAILGGVDQIHIKPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFSHRAGRDLVNVAKKRTNIIPVLEDARHPLKYRMLIGMVDVIFADVAQPDQSRILALNAHTFLRNGGHFLISIKANCIDSTASAEAVFASEVRKLQQENLKPQEQLTLEPYERDHAVVVGVYRPPPKSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LTA3</accession>
    <name>A0A8C2LTA3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted gene, 35549</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein C3orf86 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C4H3orf86</name>
        <name evidence="5" type="synonym">CUNH3orf86</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027271283.2">
        <property type="nucleotide sequence ID" value="XM_027415482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LTA3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012205.1">
        <property type="protein sequence ID" value="ENSCGRP00001008101.1"/>
        <property type="gene ID" value="ENSCGRG00001010440.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cge:107980094"/>
    <dbReference type="OMA" id="PWALPCK"/>
    <dbReference type="OrthoDB" id="9747580at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027271283.2"/>
        </source>
    </evidence>
    <sequence length="121" mass="12626" checksum="5591A912E455A771" modified="2022-01-19" version="1">MSRSQLAQERKSLDSFVWVNEITGEVTLPPGEETALAASSGEKQRRAKKSGSWRGSAARAAAAPRPASPANPEAAGGALPEQHPLGASPPPAMTLPASPSPPWALPCKLRNVLTGSNRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LUQ0</accession>
    <name>A0A8C2LUQ0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate associated transmembrane protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Cleft lip and palate transmembrane protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Clptm1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016832612.2">
        <property type="nucleotide sequence ID" value="XM_016977123.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286679.1">
        <property type="nucleotide sequence ID" value="XM_027430878.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LUQ0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012824.1">
        <property type="protein sequence ID" value="ENSCGRP00001008689.1"/>
        <property type="gene ID" value="ENSCGRG00001010928.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752525"/>
    <dbReference type="KEGG" id="cge:100752525"/>
    <dbReference type="CTD" id="1209"/>
    <dbReference type="GeneTree" id="ENSGT00530000063461"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050811">
        <property type="term" value="F:GABA receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033081">
        <property type="term" value="P:regulation of T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027286679.1"/>
        </source>
    </evidence>
    <sequence length="664" mass="75363" checksum="ECE01990DB40434A" modified="2022-01-19" version="1">MAAAQEADGAGSAVVAAGGGSSGQVTSNGSIGRDTPAETQPQNPPPQPAPNAWQVIKGVLFRIFIIWAISSWFRRGPSPQDQSGPGGAPRVASRNLFPKDTLMNLHVYISEHEHFTDFNATSALFWEQQDLVYGDWTSGENSDGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPRQKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEADPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQLYAAQSTKSPWNFLGDELYEQSDEEQDSVKVALLETSPYLLALTIIVSIVHSVFEFLAFKNDIQFWSSRQSLEGLSVRSVFFGVFQSFVVLLYILDNETNFVVQVSVFIGVLIDLWKITKVMDVRLDREHRVAGIFPCPTFKDKSTYIESSTKVYDDMAFRYLSWILFPLLGCYAVYSLLYLEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKLKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPVMYRIGCLRDDVVFFIYLYQRWIYRVDPTRVNEFGMSGEDVSALASRAQAPTAAGALTPASSTAVTEEDASTVPKATPGASTASQPQEAPPKPAEDKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LZT2</accession>
    <name>A0A8C2LZT2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase Kist</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Kinase interacting with stathmin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">PAM COOH-terminal interactor protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">U2AF homology motif kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Uhmk1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_027272867.1">
        <property type="nucleotide sequence ID" value="XM_027417066.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313889.1">
        <property type="nucleotide sequence ID" value="XM_035457998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LZT2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015877.1">
        <property type="protein sequence ID" value="ENSCGRP00001011645.1"/>
        <property type="gene ID" value="ENSCGRG00001013226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770730"/>
    <dbReference type="KEGG" id="cge:100770730"/>
    <dbReference type="CTD" id="127933"/>
    <dbReference type="GeneTree" id="ENSGT00940000157769"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071598">
        <property type="term" value="C:neuronal ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046825">
        <property type="term" value="P:regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12465">
        <property type="entry name" value="RRM_UHMK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14020">
        <property type="entry name" value="STKc_KIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000322">
        <property type="entry name" value="Serine/threonine-protein kinase Kist isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000324">
        <property type="entry name" value="Serine/threonine-protein kinase Kist isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000241">
        <property type="entry name" value="Serine/threonine-protein kinase Kist isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034372">
        <property type="entry name" value="UHMK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034371">
        <property type="entry name" value="UHMK1_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46962">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE KIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46962:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE KIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="23"/>
            <end position="304"/>
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        <location>
            <begin position="324"/>
            <end position="399"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011645.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027272867.1"/>
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    </evidence>
    <sequence length="419" mass="46519" checksum="8FDF447799E2255D" modified="2022-01-19" version="1">MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M7E9</accession>
    <name>A0A8C2M7E9_CRIGR</name>
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        <submittedName>
            <fullName evidence="5">BTB domain containing 1</fullName>
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        <submittedName>
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        </submittedName>
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        <name evidence="5 8" type="primary">Btbd1</name>
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    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
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        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07707">
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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    </dbReference>
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        <location>
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        </location>
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            <begin position="1"/>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50097"/>
        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M811</accession>
    <name>A0A8C2M811_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoinositide phospholipase C</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Plcl1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027252712.1">
        <property type="nucleotide sequence ID" value="XM_027396911.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M811"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019178.1">
        <property type="protein sequence ID" value="ENSCGRP00001014939.1"/>
        <property type="gene ID" value="ENSCGRG00001015676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772560"/>
    <dbReference type="KEGG" id="cge:100772560"/>
    <dbReference type="CTD" id="5334"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08597">
        <property type="entry name" value="PI-PLCc_PRIP_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000017">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000001">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF102">
        <property type="entry name" value="INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="114"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="586"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="702"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027252712.1"/>
        </source>
    </evidence>
    <sequence length="1096" mass="122536" checksum="9158CA8B1C75A12F" modified="2022-01-19" version="1">MAEGAAGREGPAPLDAAGGEDDPRVAADAASGDAAPAVSGGRMRDRRSGVALPGAAGAPGDSEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYEPLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDADDLMLFLEAEQGVTHITEDMCLDIIKRYELSEEGRQKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDGSDNEPILCNRNNMAMHLSFRSVLEVINKFAFVASEYPLILCLGNHCSLTQQKVMVQQMKKVFGNKLYTEAPLSSESYLPSPEKLKNMIIVKGKKLPPESDLLEGEVTDEDEEAEMSRRMSGDYNGEQKHIWLCRELSDLVSICKSVQYRDFELSMKTQNYWEICSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLVLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCAEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKELCGLPPIASLKQCLLTLSSRLITSDNAPSVSLVMKDSFPYLEPLGAMPEVQKKMLAAYDLMIQESRVLIEMADTVQEKIAQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKGPGSGAEAKGKRSLEAIEEKESSEENGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M9M1</accession>
    <name>A0A8C2M9M1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoadipate dehydrogenase complex component E1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoadipate dehydrogenase, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Alpha-ketoadipate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Dehydrogenase E1 and transketolase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Dhtkd1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoadipate + H(+) = N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:69576"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:184385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:69577"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">The 2-oxoadipate dehydrogenase complex is composed of OADH (2-oxoadipate dehydrogenase; E1a), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). E1a functional unit is a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003496471.1">
        <property type="nucleotide sequence ID" value="XM_003496423.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260976.1">
        <property type="nucleotide sequence ID" value="XM_027405175.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M9M1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020028.1">
        <property type="protein sequence ID" value="ENSCGRP00001015785.1"/>
        <property type="gene ID" value="ENSCGRG00001016298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753689"/>
    <dbReference type="KEGG" id="cge:100753689"/>
    <dbReference type="CTD" id="55526"/>
    <dbReference type="GeneTree" id="ENSGT00950000183125"/>
    <dbReference type="OMA" id="PAQYYHV"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160167">
        <property type="term" value="C:oxoadipate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160166">
        <property type="term" value="F:2-oxoadipate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000005">
        <property type="entry name" value="probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000005">
        <property type="entry name" value="Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000034">
        <property type="entry name" value="Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="569"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027260976.1"/>
        </source>
    </evidence>
    <sequence length="920" mass="102903" checksum="54CDEDB223EC29D7" modified="2022-01-19" version="1">MASATMAAARRGLCLSVSLLRRGYQTERGVYGYRPRKAESSEPRGDHARLSVDHGLARLVTVYCEHGHKAAQINPLFPGQALLDTVPEIQALVQTLQGPFTTTGLLNMGKEEASLEEVLAYLNHIYCGPISIETTQLQSQEEKDWFARRFEELKKETFTTEERKQLAKLLLESQEFDHFLATKFATVKRYGGEGAESMMGFFHELLKSSAYGGITDIIIGMPHRGRLNLLTGLLQLPPELMFRKMRGLSEFPENVSATGDVLSHLTSSVDLDFGAHHPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSREDGDYSLHSSAQPGDKVICLQVHGDASFCGQGIVLETFTLSNLPHFRIGGSIHLIVNNQLGYTTPAERGRSSLYSSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIVDLLCYRQWGHNELDEPFFTNPVMYKIIRARKSIPDTYAEHLIASGLMTQEEVSDIKSSYYTKLNDHLTNVAHYSPPATNLQAHWQGLVQPEAHITTWDTGVPLELLRFIGVKSVEVPEELQLHNHLLKMYVQSRMEKVKSGTDLDWATAETLALGSLLAQGFNVRLSGQDVGRGTFSQRHAMVVCQNTDNAYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDSDTVNMFVVHPTTPAQYFHLLRRQMIRNFRKPLIIASPKVLLRYPAAVSTLQEMAPGTAFKPVIGDSSVDPKNVKTLIFCCGKHFYALLKQRESLGTKKHDFAIIRIEELCPFPLDSLQQEMSKYKHVKDIIWSQEEPQNMGPWFFVSPRFEKQLACKLRLVSRPPLPAPAVGIGTVHQQQHEDILTKTFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ME43</accession>
    <name>A0A8C2ME43_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Scn9a</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cell membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the sodium channel (TC 1.A.1.10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276063.1">
        <property type="nucleotide sequence ID" value="XM_027420262.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001021801.1">
        <property type="protein sequence ID" value="ENSCGRP00001017557.1"/>
        <property type="gene ID" value="ENSCGRG00001017498.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751370"/>
    <dbReference type="KEGG" id="cge:100751370"/>
    <dbReference type="CTD" id="6335"/>
    <dbReference type="GeneTree" id="ENSGT00940000161368"/>
    <dbReference type="OrthoDB" id="2984333at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033268">
        <property type="term" value="C:node of Ranvier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098870">
        <property type="term" value="P:action potential propagation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048266">
        <property type="term" value="P:behavioral response to pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050974">
        <property type="term" value="P:detection of mechanical stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050965">
        <property type="term" value="P:detection of temperature stimulus involved in sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000001">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000006">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000004">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000005">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000001">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000003">
        <property type="entry name" value="Voltage-dependent sodium channel"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QDE7</accession>
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            <fullName evidence="2 5">Transmembrane protein 220</fullName>
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    <gene>
        <name evidence="2 5" type="primary">Tmem220</name>
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    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027282927.1">
        <property type="nucleotide sequence ID" value="XM_027427126.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297220.1">
        <property type="nucleotide sequence ID" value="XM_035441329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QDE7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001004874.1">
        <property type="protein sequence ID" value="ENSCGRP00001003391.1"/>
        <property type="gene ID" value="ENSCGRG00001004087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770411"/>
    <dbReference type="KEGG" id="cge:100770411"/>
    <dbReference type="CTD" id="388335"/>
    <dbReference type="GeneTree" id="ENSGT00390000009386"/>
    <dbReference type="OrthoDB" id="9924288at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029377">
        <property type="entry name" value="TMEM220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34262">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34262:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15071">
        <property type="entry name" value="TMEM220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027282927.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18516" checksum="16DA4B99CD15F384" modified="2022-01-19" version="1">MALAVASWAPGLWRACNALMAAFFALAAVVQVNDPDAEFWVVVYMIPAVLTLLVGFNPLVTGNFVWKSVSVIHMLFCVLWAGNLAYHFLLHAQQSILNEEEGRELSGLVIITAWMALCHSSAKNPVGGRMHLTIAVVIALFPLISWVYVYMNKEMRASWPTHCKTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QIQ4</accession>
    <name>A0A8C2QIQ4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease pancreatic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Ear11</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2000" name="Proc. Natl. Acad. Sci. U.S.A." volume="97" first="4701" last="4706">
            <title>Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selection.</title>
            <authorList>
                <person name="Zhang J."/>
                <person name="Dyer K.D."/>
                <person name="Rosenberg H.F."/>
            </authorList>
            <dbReference type="PubMed" id="10758160"/>
            <dbReference type="DOI" id="10.1073/pnas.080071397"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the pancreatic ribonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001231445.2">
        <property type="nucleotide sequence ID" value="NM_001244516.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QIQ4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018868.1">
        <property type="protein sequence ID" value="ENSCGRP00001014631.1"/>
        <property type="gene ID" value="ENSCGRG00001015465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100689289"/>
    <dbReference type="KEGG" id="cge:100689289"/>
    <dbReference type="GeneTree" id="ENSGT00940000162253"/>
    <dbReference type="OMA" id="WAQWFEI"/>
    <dbReference type="OrthoDB" id="9450033at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002227">
        <property type="term" value="P:innate immune response in mucosa"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06265">
        <property type="entry name" value="RNase_A_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.130.10:FF:000001">
        <property type="entry name" value="Ribonuclease pancreatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.130.10">
        <property type="entry name" value="Ribonuclease A-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001427">
        <property type="entry name" value="RNaseA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036816">
        <property type="entry name" value="RNaseA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023411">
        <property type="entry name" value="RNaseA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023412">
        <property type="entry name" value="RNaseA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437:SF3">
        <property type="entry name" value="EOSINOPHIL CATIONIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00074">
        <property type="entry name" value="RnaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00794">
        <property type="entry name" value="RIBONUCLEASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00092">
        <property type="entry name" value="RNAse_Pc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54076">
        <property type="entry name" value="RNase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00127">
        <property type="entry name" value="RNASE_PANCREATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038206408" description="Ribonuclease pancreatic" evidence="13 18">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease A-domain" evidence="14">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="NP_001231445.2"/>
        </source>
    </evidence>
    <sequence length="158" mass="17789" checksum="632C53288D2379C3" modified="2022-01-19" version="1">MGVKLLESRLCLLLLLGFVIMVASFQIPPGLTPSQWFEIQHVNNRTNLRCNPAMRIVNGYTRRCKNINTFLNTSFPAVARVCGRPNTNCTRSPGTNCHNSSAQVSLTYCNLTNPGSHYTQCQYQMTPARKFYRVACNNRTPQDNGSYAVVPVHLDDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QLK9</accession>
    <name>A0A8C2QLK9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Neurogenic locus notch homolog protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37 40" type="primary">Notch3</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="39" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="40" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="26">Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Interacts (via Sushi domain 21) with ITGA9:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction. Interacts (via Sushi domain 21) with ITGA4:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction. Interacts with ANGPT1 and ANGPT2. Interacts with PEAR1 (via extracellular domain). Interacts with HSPG2, TLN1, FN1, COPA, CCT2, IQGAP1, LAMC1 and NID1. Interacts (via C-terminus) with TIE1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOTCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027275284.2">
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    <sequence length="2317" mass="244067" checksum="230AD05EB6FACDA1" modified="2022-01-19" version="1">MGPGARGRRRRRRLMALPPPPPPMRALPLLLLLAGPGAAASPCLDGSPCANGGRCTQQPSREAACLCLPGWVGERCQLEDPCHSGPCAGRGICQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGAPCSVGSDGRFACSCPPGYQGRSCRSDIDECRAGGPCRHGGTCLNTPGSFRCQCPLGYTGLLCENPIVPCAPSPCRNGGTCRQSSDTTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNLLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVSGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCERNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRYGGKCLDLVDKYLCRCPPGTTGVNCEVNIDDCASNPCTFGVCHDGINRYDCICQPGFTGPLCNVEINECASSPCGDGGSCVDGENGFRCLCPPGSLPPLCLPANHPCAHKPCSHGVCHDASGGFRCVCEPGWSGPRCSQSLAPDACESQPCQAGGTCTSDGIGFHCTCPPGFQGRQCEVLSPCIPSLCEHGGHCESDPGQLTVCSCPPGWQGSRCQQDVDECAGALPCGPHGTCTNLPGSFRCLCHEGYTGPFCDQDIDDCDPNPCLNGGSCQDGVGSFSCSCLTGFAGPSCAWDVDECLSSPCGPGTCTDHVSSFTCACPPGYGGFHCENDLLDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGTHCQYEADPCLSQPCLHGGICNPTHPGFQCICREGFTGSHCQILVDWCSQSPCQNGGRCVKTGAYCICPPGWSGRLCDIQNLPCKEAAVQMGVRLEQLCQAGGQCVDKGHSHYCVCPEGRTGSYCEQEVDPCTAQPCHHGGTCRGYMGGYVCECPAGYSGDSCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGSSLDSGPRCLHNGTCVDLVGGFRCNCPPGYTGLHCEADINECRPGACHAAHTRDCLQDPGGHFHCLCHPGFTGPRCQTALSPCESQPCQHGGQCHPSAGQEGGLTFTCHCVQPFWGLRCERVARTCRELQCPMGIPCQQTARGPRCACPPGLSGSFCRISRVSPSGATNASCAAAPCLHGGSCLPVQIAPFFRCVCAPGWAGPRCETPSTAPEVPEEPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDCSLNVDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCYAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPYHRPSPGSESRVRRELGPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPPEQSVPLLPLLVAGAIFLLVIFILGVMVARRKREHSTLWFPEGFALHKDIAAGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDSECPEAKRLKVEEPGMGAEEPVDCRQWTQHHLVAADIRVAPAMALTPPQGDADTDGMDVNVRGPDGFTPLMLASFCGGALEPMPAEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSFEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHSLGPLLCPPGAFLPGLKAVQSGTKKSRRPPGKMGLGPQGTRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFSLEGPYATTATAVSLAQLGASRAGPLGRQPPGGCVLSLGLINPVAVPLDWARLPPPAPPGPSFLLPLAPGPQILNPGTPVSPQERPPPYLAAPGHGEEYPAAGTHSSPTKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSDSTPSPATASGATVAGALPAQPHPMSAPSLPQAQTQLGSQPEVTPKRQVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QMD8</accession>
    <name>A0A8C2QMD8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Slc9a2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003499846.1">
        <property type="nucleotide sequence ID" value="XM_003499798.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242548.1">
        <property type="nucleotide sequence ID" value="XM_027386747.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QMD8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026540.1">
        <property type="protein sequence ID" value="ENSCGRP00001022295.1"/>
        <property type="gene ID" value="ENSCGRG00001020868.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757298"/>
    <dbReference type="KEGG" id="cge:100757298"/>
    <dbReference type="CTD" id="6549"/>
    <dbReference type="GeneTree" id="ENSGT00940000156807"/>
    <dbReference type="OMA" id="INMFRTI"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001953">
        <property type="entry name" value="NHE-2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032103">
        <property type="entry name" value="NHE_CaM-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF89">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16644">
        <property type="entry name" value="NEXCaM_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01086">
        <property type="entry name" value="NAHEXCHNGR2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679330" description="Sodium/hydrogen exchanger" evidence="15">
        <location>
            <begin position="35"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="16">
        <location>
            <begin position="89"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/hydrogen exchanger regulatory region" evidence="17">
        <location>
            <begin position="576"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="649"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="733"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027242548.1"/>
        </source>
    </evidence>
    <sequence length="814" mass="91880" checksum="45EC32DA03AC3A76" modified="2022-01-19" version="1">MGPSGTECSVRAPSSRLLLLLLFLQVAVPAGALAETLLDAPRARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENFGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIHTVDVFAGIANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPASVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDRYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKLRKLTPVEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSLNRERRASTSTSRYLSLPKNTKLPEQLQRKKISNEDGNSSDSDTDNGTTVLNLQPRSRRFLPDQFSKKASQSYKMEWKNEVDMDGSARVQPSTPPVPRSKEGGTQTPGVLRQPLLSKDQQFGRGRENSLTEDVPPKPPPRLVRRASEPGNRKSRIGNEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EYQ8</accession>
    <name>A0A9J7EYQ8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Diacylglycerol kinase</fullName>
            <shortName evidence="21">DAG kinase</shortName>
            <ecNumber evidence="21">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">Dgkh</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="20">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the eukaryotic diacylglycerol kinase family.</text>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046339">
        <property type="term" value="P:diacylglycerol metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="C1_DGKeta_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="CDD" id="cd09507">
        <property type="entry name" value="SAM_DGK-delta-eta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000001">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.60.20:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000029">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000001">
        <property type="entry name" value="Diacylglycerol kinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-NAD_kinase_N"/>
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        <property type="entry name" value="C1-like_sf"/>
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        <property type="entry name" value="C1_DGKeta_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054474">
        <property type="entry name" value="DGKD_4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF37">
        <property type="entry name" value="DIACYLGLYCEROL KINASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22944">
        <property type="entry name" value="DGKD_4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 21 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="23">
        <location>
            <begin position="83"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="26">
        <location>
            <begin position="346"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="25">
        <location>
            <begin position="1165"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="660"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027245878.1"/>
        </source>
    </evidence>
    <sequence length="1233" mass="136695" checksum="4B02F3542AE2D447" modified="2023-06-28" version="1">MDPQHVRPALGVRSLAWEEPEPERMAGAGSQHHPPGGAAAGTSAVSPTAAGPGEDSSDSEAEQEGPQKLIRKVSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQSREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPVCPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQVGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPAKASLLPQPPEASEGFYMTIYEDSVSNHLTKILNSDEQAVILSSAKILCETVKDFVAKVEKAQDKALENTVVAEAVANKCSVLNEKLEQLLQALHADTQASRVPLGVSPAIPEEDAVESSSEESLGESKDQLVNDIAKPSSQKAMKPQEIMLRANSLKKAVRQVIEEAGKVMDEQTVQPCESISPSCDYDSPEAEESKDDDSKESPAAKSTSQSPDAQASRGHFQTDSVTGSAMATTKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSLEGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPILRANLYIHPAADLATEEVSQMRLCSQAAEELITSICDAATIHCLLEQELAHAVNACSHALNKANPRFPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEERVSSALHSVEVELQKLMEIPWLYYILHPNEDEEPPMDCTKRNNKSTVFRIVPKFKKEKAQKQKTSSQAVQNWGTEEVAAWLDLLNLGEYKEIFIRHDIRGAELLHLERRDLKDLGIPKVGHMKRILQGIKELERNAPNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F868</accession>
    <name>A0A9J7F868_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Collagen alpha-1(VI) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Col6a1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Collagen VI acts as a cell-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type VI collagen family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003500605.1">
        <property type="nucleotide sequence ID" value="XM_003500557.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250075.1">
        <property type="nucleotide sequence ID" value="XM_027394274.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F868"/>
    <dbReference type="GeneID" id="100755078"/>
    <dbReference type="KEGG" id="cge:100755078"/>
    <dbReference type="CTD" id="1291"/>
    <dbReference type="OrthoDB" id="8889285at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005589">
        <property type="term" value="C:collagen type VI trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01480">
        <property type="entry name" value="vWA_collagen_alpha_1-VI-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000026">
        <property type="entry name" value="Collagen, type VI, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000050">
        <property type="entry name" value="Collagen, type VI, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000060">
        <property type="entry name" value="Collagen, type VI, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF18">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 17" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039919658" description="Collagen alpha-1(VI) chain" evidence="14">
        <location>
            <begin position="29"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="45"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="623"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="836"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="261"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027250075.1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="109747" checksum="FD27AFFF79F3D726" modified="2023-06-28" version="1">MVTRRPARNMRLALALLPLLLQACWVATQDIQGSKPIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGLTRMPSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGHSRDAEETISQTIDTIVDMIKNNVEQVCCTFECQAARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKGETGFPGLPGCKGSPGFDGIQGPPGPKGDAGAFGPKGEKGEAGADGEAGRPGSSGPPGDEGDPGEPGPPGEKGEAGDEGNAGPDGPPGERGGPGERGPRGTPGVRGPRGDPGESGPQGDQGREGPIGIPGDPGEAGPIGPKGYRGDEGPPGPEGLRGAPGPAGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGNRGPPGINGTKGYPGLKGDEGEVGDPGEDNNDISPRGAKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSESIGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNIRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPLSVLCGPDIQVVSVGIKDVFGFVAGSDQLNVISCQGLLSQGRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHNFETTKVFAKRLAERFLSAGRTDPSQEVRVAVVQYSGLGQQQPGRAALQFMQNYTVLASSVDSMDFINDATDVNDALSYVTRFYRETSPGAAKKRVLLFSDGNSQGATAEAIEKAVQEAQRAGIEIFVVVVGPQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVFYQTVSRKVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FG51</accession>
    <name>A0A9J7FG51_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">StAR-related lipid transfer protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">START domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Stard4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <dbReference type="RefSeq" id="XP_027256491.1">
        <property type="nucleotide sequence ID" value="XM_027400690.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FG51"/>
    <dbReference type="GeneID" id="100774302"/>
    <dbReference type="KEGG" id="cge:100774302"/>
    <dbReference type="CTD" id="134429"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070508">
        <property type="term" value="P:cholesterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010879">
        <property type="term" value="P:cholesterol transport involved in cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000054">
        <property type="entry name" value="StAR-related lipid transfer protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042555">
        <property type="entry name" value="StarD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47006">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47006:SF1">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="8">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027256491.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23881" checksum="8ED84005E07A5A12" modified="2023-06-28" version="1">MESLSDVASFSTKLQNTLIQYHSIEEDKWRVAKKMKDVTVWRKPSEEFSGYLYKAQGVMDDVVNSVIDHIRPGPWRLDWDRLMTSLDILEHFEENCCVMRYTTAGQLLNIISPREFVDFSYTVGYEEGLLSCGVSLDWSETRPEFVRGYNYPCGWFCVPVKDNPSQSLLTGYIQTDLRGMIPQSAVDTAMASTLTNFYGDLRKALRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FIM8</accession>
    <name>A0A9J7FIM8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protein spire homolog 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Spire1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258496.1">
        <property type="nucleotide sequence ID" value="XM_027402695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FIM8"/>
    <dbReference type="GeneID" id="100760597"/>
    <dbReference type="KEGG" id="cge:100760597"/>
    <dbReference type="CTD" id="56907"/>
    <dbReference type="OrthoDB" id="10043757at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15767">
        <property type="entry name" value="FYVE_SPIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22078">
        <property type="entry name" value="WH2_Spire1_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22080">
        <property type="entry name" value="WH2_Spire1_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22065">
        <property type="entry name" value="WH2_Spire_1-2_r1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000455">
        <property type="entry name" value="protein spire homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029905">
        <property type="entry name" value="Spir-1_FYVE-rel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF8">
        <property type="entry name" value="PROTEIN SPIRE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="15">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="365"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="470"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027258496.1"/>
        </source>
    </evidence>
    <sequence length="785" mass="88920" checksum="9468B6F634ACE9D3" modified="2023-06-28" version="1">MAQPSSPGGEGPQFGATGDSRDALSLEEILRLYNQPINEEQAWAVCFQCCGSLRATAARRQPHRRVRSAAQIRVWRDGAVTLAPAAGEEGEPPPASGKLGYSHCTETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDQMANTVEADGNSDEGYEAADEGPEDEDGGKRNISAIRSYQDVMKICAAHLPAESEAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKTDESSTDLEDLKNADWARFWVQVMRDLRNGVKLKKVQQRQYNPLPIEYQLTPYEMLMDDIRCRRYTLRKVMVNGDIPPRLRKSAHEIILDFIRSRPPLNPASARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSKLDVTTPDSSKNVGESSMVNGGLASQTKENGLGAAQPGPAQRKKLLKAPTLAELDSSDSEEETLHKSTSSSSASPSLYEDPVLEAMCTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLVPRITSVWPRTPFRPLFSTIQTASLLSSHPFEAAMFGVAGAMYYLFERAFTSRWKPSKEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDVYTALKKGKLCFCCRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESCPRPEKSSTAHHRPLRSIARFSSKSKSVDKSDEELQFPKEFMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSAGPSEYCPSERTINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FMS9</accession>
    <name>A0A9J7FMS9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphodiesterase</fullName>
            <ecNumber evidence="15">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Pde6c</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_003500756.1">
        <property type="nucleotide sequence ID" value="XM_003500708.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263238.1">
        <property type="nucleotide sequence ID" value="XM_027407437.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FMS9"/>
    <dbReference type="GeneID" id="100752813"/>
    <dbReference type="KEGG" id="cge:100752813"/>
    <dbReference type="CTD" id="5146"/>
    <dbReference type="OMA" id="LICNMMN"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000010">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0844">Vision</keyword>
    <feature type="domain" description="PDEase" evidence="17">
        <location>
            <begin position="483"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="559"/>
            <end position="563"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="773"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027263238.1"/>
        </source>
    </evidence>
    <sequence length="858" mass="98729" checksum="D2BC100E56EC7769" modified="2023-06-28" version="1">MTEISQDAVERYLQENPQFAQEYFDKKLRVGLLFKNSHPGVQASMTLPEMMQVEEAALRLELLQCMQDEAGSAEQVTHRALQRLAQLLQADCCSMFICRARNGIPEVASRLLDITPTSKFEDNLVAPDREVVLPLDIGIVGWVAHVKTAVNVSDVKKNSHFSDFMDKQTGYVTKNLLAVPIVMGKEVLAVVMAVNKINAPEFSKQDEEVFSKYLSFVAVALRLQHTGYLYSVESRRSQILMWSANKVFEELTDVERQFHKALYTIRTYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREIIFYKIIDYILHGKEEINVIPSPPADHWTLLSGLPTYVAENGFICNMLNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEYDEHITETLTQFLGWSLLNTDTYERVNRLESRRDLAQEMIMSRTKATPDEIGSILKFKEKLCVDVIEECEERQLLALLKEDLPDPRTTDLYEFCFSDFPVTEHELVKCGLRLFFEINAVEKFKVPVEVLTRWMYTVRKGYRPVTYHNWRHGFNVGQTMFTLLLTGGLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSASPLAKLHGTSILERHHLEYSKTLLQDESLNIFQNLSKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQSEEEAIKYVTTDPTKKEVIMAMMMTACDLSAITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRNKKDELPKLQVGFIDFVCTFVYKEFSRFHREITPMLNGLQNNRVQWKSLADEYEAKVRVTQEEGRKQEEGAVDGKAATDLGGGTDYKKSKTCLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FRL8</accession>
    <name>A0A9J7FRL8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor-like GTPase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Elongation factor Tu GTP-binding domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Elongation factor-like 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein FAM42A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Efl1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="RefSeq" id="XP_003513248.1">
        <property type="nucleotide sequence ID" value="XM_003513200.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263350.1">
        <property type="nucleotide sequence ID" value="XM_027407549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FRL8"/>
    <dbReference type="GeneID" id="100763625"/>
    <dbReference type="KEGG" id="cge:100763625"/>
    <dbReference type="CTD" id="79631"/>
    <dbReference type="OMA" id="FARCDIQ"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000732">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000066">
        <property type="entry name" value="Elongation factor Tu GTP-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000044">
        <property type="entry name" value="elongation factor-like GTPase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="427"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="924"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027263350.1"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125791" checksum="76379A444499B8BE" modified="2023-06-28" version="1">MVLNGVDKMIQLQKHTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHYAEGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKLDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETDSQVKTQSEQGDQVYDWSTGLEDADDSQLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLLKTLWGDYYINMKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCQKLPSPLDMTSERVEKLMCTGSQTFESLPLETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKTLPQNKPRPLTQEEIAQRRERARQRHAERLAGTQGQAPQGPTQDGGTLETGPQGDEPRGDEPDVASISPQPVAQEESSQEAFIAFARVFSGIARRGQKIFVLGPKYSPVEFLQRVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLVTAGEVHLQRCLDDLRERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGRQQKVAVIHQTKEEQSKIPEGIHVDSDGLITITTPNKLATLSVRAIPLPEEVTQILEENSDLIRSMELLTSSLNEGRNTQGIHQKTQEKIWDFKGKLEQHLIGRKWRNTVDQIWSFGPRKCGPNILVSRSEDFQNSVWSGPAGKESKEASRFRDFGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWELNKCAEQGASDKQNQKQCDLAEEGQEEGKTCHSGDENQEQQDGCSEPFEETSPKGESPVTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEVRKRTSGLASPQLVFSHWEVIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FUL6</accession>
    <name>A0A9J7FUL6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MIX23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Coiled-coil domain-containing protein 58</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ccdc58</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007639988.2">
        <property type="nucleotide sequence ID" value="XM_007641798.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268557.1">
        <property type="nucleotide sequence ID" value="XM_027412756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FUL6"/>
    <dbReference type="GeneID" id="100767366"/>
    <dbReference type="CTD" id="131076"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027268557.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14213" checksum="9C70F6AFE19FE0A1" modified="2023-06-28" version="1">MRTIDDRIVHELNTTVPTASFAGKIDASQTCKQLYESLMAAHASRDKVIKNCIAQTSAVVKSLREEREKNLDDLTLLKQLRKEQTKLKWMQSELNVEEVVNDRSWKVFNERCRIHFKPPKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FWL3</accession>
    <name>A0A9J7FWL3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IQ domain-containing protein F2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Iqcf2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
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                <person name="Samoudi M."/>
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                <person name="Kingham B."/>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">17A/GY</strain>
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            <strain evidence="4">17A/GY</strain>
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            <strain evidence="5">17A/GY</strain>
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    <dbReference type="AlphaFoldDB" id="A0A9J7G2S1"/>
    <dbReference type="GeneID" id="103160846"/>
    <dbReference type="KEGG" id="cge:103160846"/>
    <dbReference type="CTD" id="254170"/>
    <dbReference type="OrthoDB" id="8757000at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22104">
        <property type="entry name" value="F-box_FBXO33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF3">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027275439.2"/>
        </source>
    </evidence>
    <sequence length="556" mass="62168" checksum="2EEB6A8117A7A695" modified="2023-06-28" version="1">MLLFLSVPQPRPPGARTRSGAARVVRQRRRQRRRLRGLLRGLRGRAAAGGGRPGRMALCGQAAGAASLPSELIVHIFSFLSPPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENSLSGGGGPGDGGGGGGADMGTEGEDGEALRLSSRWLEVLRVYLELVLCVLLSIRNNRNLQKFSLFGDVSVVQQQGSLSSTDLSRVDPDCKKIKQIQQLFEEVLSNSRQLKWLSCGFMLEIVTPTSLSSLSNSIANTMEHLSLLDNNIPGNSTLITAVELERFVNLRSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMNKSLDNMPNDEHWKALSRKSSSLRVYLMAFDVKGEDMLKILKPSIPLERVHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLTLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVNNLVEQVSLGLGQPWHAVLDIESLSVFTEPNRHFYREMQSFSEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G7B0</accession>
    <name>A0A9J7G7B0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100759083</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276700.1">
        <property type="nucleotide sequence ID" value="XM_027420899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G7B0"/>
    <dbReference type="GeneID" id="100759083"/>
    <dbReference type="KEGG" id="cge:100759083"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15226">
        <property type="entry name" value="7tmA_OR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000012">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="59"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276700.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37098" checksum="F7C2C4D87E9BB350" modified="2023-06-28" version="1">MFIVLSKASADTIFWNESTKQANHSVVTEFIFIGLSDSQELQIFLFALFFVFYVGIVFGNLLIVITVTADSHLHSPMYFLLANLSFIDLSLSSVTAPKMIADFFNKHKVISVKGCLAQIFLLHFFGGSELVTLIAMGFDRYIAICKPLRYSTIMRGNVCIGIVVAAWGVGFLHSVSQLAFAVNLPFCGPNKVDSFYCDLPRVIKLACTDTYRLDIMVVANSGILTVCSFVLLIISYTVILMTIQRRPSDRSYKALSTLTAHITVVLLFFGPCIFIYAWPFPTKSLDKFLAVFYSVVTPLLNPIIYTLRNTEMKTAMRRLRQWNLNFSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GAG2</accession>
    <name>A0A9J7GAG2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WAP four-disulfide core domain protein 6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC118237616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027279047.2">
        <property type="nucleotide sequence ID" value="XM_027423246.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293887.2">
        <property type="nucleotide sequence ID" value="XM_027438086.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GAG2"/>
    <dbReference type="GeneID" id="118237616"/>
    <dbReference type="KEGG" id="cge:118237616"/>
    <dbReference type="OMA" id="CPKVKVH"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22611">
        <property type="entry name" value="Kunitz_eppin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000015">
        <property type="entry name" value="WAP four-disulfide core domain 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.75.10:FF:000004">
        <property type="entry name" value="WAP four-disulfide core domain 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051388">
        <property type="entry name" value="Serpin_venom_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46751">
        <property type="entry name" value="EPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46751:SF1">
        <property type="entry name" value="WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039916429" evidence="7">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027279047.2"/>
        </source>
    </evidence>
    <sequence length="136" mass="15893" checksum="79754511FA91644E" modified="2023-06-28" version="1">MRLWGLLPFLVPFIFPWGIWEPELAEGFFAGSCPRVRVKCEIEERNECTRHRHCPEKKRCCLFSCGKKCLDIKQDVCSLPQEAGPCLAYLPRWWYNKETELCTEFIYGGCQGNPNNFQTEGICRVICKKKHLSSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GAQ0</accession>
    <name>A0A9J7GAQ0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein CLEC16A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Clec16a</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016836030.1">
        <property type="nucleotide sequence ID" value="XM_016980541.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280594.1">
        <property type="nucleotide sequence ID" value="XM_027424793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GAQ0"/>
    <dbReference type="GeneID" id="100768590"/>
    <dbReference type="KEGG" id="cge:100768590"/>
    <dbReference type="CTD" id="23274"/>
    <dbReference type="OrthoDB" id="294052at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="4">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="243"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="901"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="922"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027280594.1"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119106" checksum="52C7C768326FF0BB" modified="2023-06-28" version="1">MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENPEKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYTKPAQDVPRSSAKPSIRCFIKPTETLERSLEMNKHKGKKRMQKRPNYKNVGEEEDEERGPAEDAQEDAEKAKGTEGGSKSMKTSGEREEIEMVIMERSKLSELATAGASVREQNTTDEEKSAATGSESTQLSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLKRIQLPVPSAAEKTTYNHLLAERLIRIMNNAAQPDGRIRLATLELSCLLLKQQVLTRSGCIIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTIKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRREKFPEAEFLIQRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGLVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFVFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLSNSSSQHLPFRFYDQCRRGSSDPTVQRSVFASVDKVPGFAVAQCINQHSSPSLSSPSPPSASGSPGGSGSTSHYDSGGSSSTPSAAQSPADAPTTPEQPQPHLLDQSVIVNEMDVNSKPSKNLARSSEVETMHLAPSLLPAQQPTISLLYEDTADTLSVESLTLVPPVDPHSLRALTGIPQNSTLAAAGTETPDEDTVYPESASPTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GAQ9</accession>
    <name>A0A9J7GAQ9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Hepatitis A virus cellular receptor 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100769223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the immunoglobulin superfamily. TIM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027280624.1">
        <property type="nucleotide sequence ID" value="XM_027424823.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297713.1">
        <property type="nucleotide sequence ID" value="XM_027441912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GAQ9"/>
    <dbReference type="GeneID" id="100769223"/>
    <dbReference type="KEGG" id="cge:100769223"/>
    <dbReference type="OrthoDB" id="8447307at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001618">
        <property type="term" value="F:virus receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033005">
        <property type="term" value="P:positive regulation of mast cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000774">
        <property type="entry name" value="Hepatitis A virus cellular receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052331">
        <property type="entry name" value="TIM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47009:SF11">
        <property type="entry name" value="CDNA SEQUENCE BC053393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47009">
        <property type="entry name" value="HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039935415" evidence="13">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027280624.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="28463" checksum="11579FBDEA555C04" modified="2023-06-28" version="1">MRHTQVLISVLLLLLPAAVSSFPEVHGVVGHPVTLPCSYPVPNGISSMCWGRGECRDTCGQTLIWTDGHRIYYQTSNRYQLKGQNLEGHVSLTIKNVTVSDSGLYCCRVEMKGPNGVQKLTISLQVQPEIPTSPPRGHTTITTSTTTSTRLTGAPKSTRISTSTPLPPSDTLTPKPGYLEVQIRLEQHCDIFRPRLEQSHCKHIPPCVHNQVPLSLKTLPEVFPTKIPLRDTTKITYVGISIAILLLLLLASVLIFASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GB56</accession>
    <name>A0A9J7GB56_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium-independent sulfate anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 26 member 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Slc26a11</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). In the kidney, mediates chloride-bicarbonate exchange, facilitating V-ATPase-mediated acid secretion. May function as a chloride channel, playing an important role in moderating chloride homeostasis and neuronal activity in the cerebellum.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate(in) + chloride(out) = hydrogencarbonate(out) + chloride(in)</text>
            <dbReference type="Rhea" id="RHEA:72363"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>oxalate(in) + chloride(out) = oxalate(out) + chloride(in)</text>
            <dbReference type="Rhea" id="RHEA:72263"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>sulfate(in) + H(+)(in) = sulfate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28574"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027281288.1">
        <property type="nucleotide sequence ID" value="XM_027425487.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100757714"/>
    <dbReference type="KEGG" id="cge:100757714"/>
    <dbReference type="CTD" id="284129"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140900">
        <property type="term" value="F:chloride:bicarbonate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000013">
        <property type="entry name" value="Solute carrier family 26 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0039">Anion exchange</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="21">
        <location>
            <begin position="463"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027281288.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="63933" checksum="F0AB380394ABEB24" modified="2023-06-28" version="1">MAPDTCCCSRRALQRRLPFLAWLPVYSLQWLPMDFIAGLSVGLTVIPQALAYAEVAGLPPQYGLYSAFTGCFVYFFLGTSRDVTLGPTAIMSLLVSFYTLHEPAYAVLLAFLSGCIQLAMGFLHLGFLLDFISCPVIKGFTSAATITIGFGQIKNLLGLQRIPRQFFLQVYHTFLHISETRVGDAVLGLACMVLLLALKLMREGVPPPDPETPLCVKLSRGLVWTVTTARNALVVSFAALIAYSFEVTGHHPFVLTGKIAEGLPPVRAPPFSVTTDNKTISFSEMVQNMGTGLAVVPLVGLLESIAVAKSFASQNNYRIDANQELLAIGLTNVLGSLVSSYPVTGSFGRTAVNAQTGVCTPAGGLVTGVLVLLSLNYLTSLFYYIPKSALAAVIIMAVAPLFDAKIFRTLWRVKRLDLLPLSVTFLLCFWEVQYGILAGTLVSLLILLHFVARPKTQVSEGRILVLQPASGLHFPAIDALREAIMNRALEAPLPRCAVLECTHVSCIDYTVVVGLSELLEDFQKRGVTLAFVGLQVPVLRTLLAADLKGLQYFTTLEEAEKCLQQEPGPQPHADLEDSXPEPRISLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GFX1</accession>
    <name>A0A9J7GFX1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Elongation factor sec</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Eukaryotic elongation factor, selenocysteine-tRNA-specific</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Eefsec</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027284485.1">
        <property type="nucleotide sequence ID" value="XM_027428684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GFX1"/>
    <dbReference type="GeneID" id="100761746"/>
    <dbReference type="KEGG" id="cge:100761746"/>
    <dbReference type="CTD" id="60678"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01889">
        <property type="entry name" value="SelB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000900">
        <property type="entry name" value="Eukaryotic elongation factor, selenocysteine-tRNA-specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000052">
        <property type="entry name" value="Selenocysteine-specific elongation factor EF-Sec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="19">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027284485.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="67203" checksum="292E98B6EAE6794A" modified="2023-06-28" version="1">MAGRRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQPQSRERGITLDLGFSCFVVPLPGAEPGTGDTQLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLAEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEAPQGISELIELLKSQISIPARDPSGPFLMSVDHCFSIKGQGTVMTGTILSGTISLGDSVEIPALKVVKKVKSMQMFHTPVTSATQGDRLGICVTQFDPKLLERGLVCAPESLHTIHAALISVEKIPYFRGLLQTKAKFHITVGHETVMGRMLFFSPAPDNFDLEPTLDSFDLSREYLFQEQYLCKDSMPTATEGGDEVDRKADDTPGGQCPRQQWALVEFEKPVTCPQLCLVIGSRLDADIHTNTCRLAFHGVLLQGLEDKNYTESFLPALRVYKLKHKHGLVERVMDDYSVIGRSLFKKETNIQLFVGLKVQLSTGEQGIIDSAFGQSGKFKIHIPAVACVLVTPEPSTLVLPPFHEKSGTEDFRASFLGGLSPESKKILTPTLKKRNRAGRGETTKQEEGTERPEPMQPVTLSLSFKRYVFDTQKRMVQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GI29</accession>
    <name>A0A9J7GI29_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cone-rod homeobox protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Crx</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027286402.1">
        <property type="nucleotide sequence ID" value="XM_027430601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770134"/>
    <dbReference type="KEGG" id="cge:100770134"/>
    <dbReference type="CTD" id="1406"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Orthodenticle homeobox 1"/>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="CONE-ROD HOMEOBOX PROTEIN"/>
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        <property type="entry name" value="HOMEOBOX PROTEIN"/>
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    <keyword evidence="7 14 15" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="9" id="KW-0804">Transcription</keyword>
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        <location>
            <begin position="119"/>
            <end position="179"/>
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    <feature type="DNA-binding region" description="Homeobox" evidence="14">
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    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="179"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027286402.1"/>
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    <sequence length="381" mass="41187" checksum="2D48B452837AC995" modified="2023-06-28" version="1">MQLAIFDAHHPPPMQHLCPPQEPRSACNHFTPRASAFRPRSCREHPATVSPPTVGKRTTAGHNTLQFGAPGLRLPPAGPGPVRTCCRISPFKFSCGHSHLPDANARQGSFIHPNLGAPRKQRRERTTFTRSQLEELEALFSKTQYPDVCAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPTGGQAKARPAKRKAGTSPRPCTDVCTESLGISDSYSPSLAGTSGSPTTAVATASIWSPASESPLSEAQXAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYASPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPYLAQSPISLSGQSYSTYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJB6</accession>
    <name>A0A9J7GJB6_CRIGR</name>
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        <recommendedName>
            <fullName evidence="13">Zinc finger protein ZFAT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Zinc finger protein 406</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC100770129</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027287502.1">
        <property type="nucleotide sequence ID" value="XM_027431701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJB6"/>
    <dbReference type="GeneID" id="100770129"/>
    <dbReference type="KEGG" id="cge:100770129"/>
    <dbReference type="OrthoDB" id="10015593at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc_finger/UBP_domain"/>
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    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
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            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
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            <end position="327"/>
        </location>
    </feature>
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        <location>
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        <location>
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            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="740"/>
            <end position="767"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
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        <location>
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            <end position="934"/>
        </location>
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        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
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            <end position="991"/>
        </location>
    </feature>
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        <location>
            <begin position="992"/>
            <end position="1020"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="535"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="637"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027287502.1"/>
        </source>
    </evidence>
    <sequence length="1241" mass="137748" checksum="EC57F3F22B983930" modified="2023-06-28" version="1">METQAAENTAIFMCKCCNLFSPNQSELLTHVSEKHGEEGVNVDDVIIPLRPLSTPEAPNPSKGGDEFLVMKRKRGRPKGSTKKPSPEEDTAESLVSPSEDGPLAPEEGSGLAPGSLECSKCCRKFSNTRQLRKHICIIVLNLGEEEADAGNNESDLELEKQYKEDDREKAPKRPRAQKTEKVQKISGKEAGQLSGAKKPIISVVLTAHEAIPGATKIIPVEAGPPETGAAPPETTAADLVPRRGYQEYAIQQTSYEQPMKSSRLGPTQLKIFTCEYCNKVFKFKHSLQAHLRIHTNEKPYKCPECSYASAIKANLNVHLRKHTGEKFSCDYCSFTCLSKGHLRVHVERVHKKIKQHCRFCKKKYSDVKNLIKHTRDAHDPQDRKVKEALDELRLMTREGKRQLLYDCHTCERKFKNELDRDRHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFVYVCAICLKKFVSSIRLRSHIREVHGAAQETLVFTSSINQSFCLLEPGGDIQQEALGDQLQLAAEEFVCPEVDVLKEGPGEAQPEVAPRELEAPGEATTSPVPLATSQTESASLSPCKVGTTVVASDLNPLGVVSDDFLLKNGTSPAESHAVAEPALDTQHGGSAQTQGEEVTLLLAKDQSARPGPENQSGQSPPGGGQNAIALPASESDSNRCLRSNPEEASDLLPAVAEGGEPGVCQADPSKPPSEHHPGSTAFMKVLDSLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQCHYSSITKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTELDKRSYSCPVCEKSFSEDRLIKSHIKTNHPEVSMNTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHIWAHEGVKPFKCSLCDYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTSDGKQFKCTVCDHTAAQKPQLLRHMEQHASFKPFRCAHCHYSCNISGSLKRHYNRKHPNEEYANVGSVELAAEALIQQGGLKCPVCSFVYGTKWEFNRHMKNKHGLKVVEIDGDPKGEAATETPEEPSTQYLYITEAEEDAQGTQAAVAALQDLRYTSESGDRLDPTAVNILQQIIELGSETHDATAVASVVAMAPGTVTVVKQVTDEEPSSNHTVMIQETLQQASVELAEQHHLVVSSDDVEGIETVTVYTQGGEASEFIVYVQEAVQPVEEQVGEQPAPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GKV7</accession>
    <name>A0A9J7GKV7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LOW QUALITY PROTEIN: dehydrogenase/reductase SDR family member on chromosome X homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC113838539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289967.1">
        <property type="nucleotide sequence ID" value="XM_027434166.2"/>
    </dbReference>
    <dbReference type="GeneID" id="113838539"/>
    <dbReference type="KEGG" id="cge:113838539"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF264">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER ON CHROMOSOME X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027289967.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="34516" checksum="2617C84809F29E38" modified="2023-06-28" version="1">MSLLGALRATLLAYAVGAAVLFRQLLRRLRGGFRPPVLPRQPGRVAIVTGGTAGIGLETARQLAALDFRVVIAGNDEATAQEVVTRIRAETQNEKVHFLFCDLASLASVRKFASDFLSLGFPLHVLVNNAGVMLAPPAXTPDGFEPHLGVNFLSHFLLTRLLLGLLRAAGSRGRRSRVVTVASATHYVGRLDVDALRASPAHSAHAAYAASKLALVLFARRLQRLLAASGDPVTSNMADPGVVATALYRGAWWGLRAAKSALGGALFKTPAEGAWTPVFVAAAPELENQGGVYFVDEAPAAPLGLSGDPGLQEAVGGGRARRGRGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GL58</accession>
    <name>A0A9J7GL58_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-X-C motif chemokine 17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113837190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027286124.1">
        <property type="nucleotide sequence ID" value="XM_027430323.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GL58"/>
    <dbReference type="GeneID" id="113837190"/>
    <dbReference type="KEGG" id="cge:113837190"/>
    <dbReference type="OrthoDB" id="9833421at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048246">
        <property type="term" value="P:macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010759">
        <property type="term" value="P:positive regulation of macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029183">
        <property type="entry name" value="CXCL17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37351">
        <property type="entry name" value="C-X-C MOTIF CHEMOKINE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37351:SF1">
        <property type="entry name" value="C-X-C MOTIF CHEMOKINE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15211">
        <property type="entry name" value="CXCL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039904335" evidence="2">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027286124.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13859" checksum="3669D6950A17B989" modified="2023-06-28" version="1">MKLLVSCFLLLLPVTLVYTVSRSPNPRVARIHGEQRQASGRWLREGGQECECRDWFLRASKRKSTPVLEPPRKQCPCDHVKGSEKKNRHQKHHRKSNRPSRTCQQFLKRCQLASFALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQB0</accession>
    <name>A0A9J7GQB0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC100753856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC100753856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035296080.1">
        <property type="nucleotide sequence ID" value="XM_035440189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GQB0"/>
    <dbReference type="GeneID" id="100753856"/>
    <dbReference type="KEGG" id="cge:100753856"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40710">
        <property type="entry name" value="RIKEN CDNA E230025N22 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40710:SF1">
        <property type="entry name" value="RIKEN CDNA E230025N22 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035296080.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52840" checksum="3F349E1BC7905F4E" modified="2023-06-28" version="1">MLASVGQGYNTALLLQGRETEAPRFVPQVLQVLFEEALPLCGSGPVLCTLSLVQISPSGQTQDLLSPCLEDLPVLDVTPLGLVVKDAREVEVSDARAASELYLKAAGHEARDCPLLRVLAGEAAGEEEGSLPWIVSWLLEGNSYSSLLLRLDPQGSSPTLLQAALLGASGKRVQVKEVRPTLWNAVEEMRARRDTLKTLRSVLLGDILTDGGLSQFERALWELQVVKAWGPRSHAPNGVRAEAVQLPEPQVKGEPPSYSMQGRHFTHFSEAGRGGFLGSGLHQTHPLRHSEEQAHQAPDVALQFFLAQARRQRLREQYRIWIQEELKHVEHQEGGACKQSKGMLAEEACEEGETQWKERTVLKLQVEALQAERDMAEHDLVALYDLYVQATRARTCHLLQVFQAWQGLWEEKAMATEHHHRSLLAGVLQDTIDLALKTQELQSRNQQLEQSADCAGVLPGEEPDQGRYGATFRCPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GRD0</accession>
    <name>A0A9J7GRD0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">eEF-1B gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100765007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in anchoring the complex to other cellular components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">EF-1 is composed of four subunits: alpha, beta, delta, and gamma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035296223.1">
        <property type="nucleotide sequence ID" value="XM_035440332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GRD0"/>
    <dbReference type="GeneID" id="100765007"/>
    <dbReference type="KEGG" id="cge:100765007"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000021">
        <property type="entry name" value="Elongation factor 1-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000088">
        <property type="entry name" value="Elongation factor 1-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="12">
        <location>
            <begin position="88"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="10">
        <location>
            <begin position="276"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035296223.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39547" checksum="3CBADA4E4676CF4E" modified="2023-06-28" version="1">MAAGTLYTYPENWRTFKTLIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKLPAGKVPAFEGDDGFCVFESNAIAYYVINEDLRGSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGIMHHNKQATKNAKEDVKQILGLLDTHLKTRTFLVGGRVTLADITVVCTLLWPYKQVLEPSFHQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAESQPKKETPRKEKGSREEKQKPQAERKEEKKAAAPAPEEEMDECEQALAAEHKAKDPFAHLPKSTFVLDEFKWKYSNEDTLSVAMPYFWEHFDKDGWSLWYAEYRFPEELIQTFMSCNLITGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GXI1</accession>
    <name>A0A9J7GXI1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MICAL C-terminal-like protein isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Micalcl</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035298178.1">
        <property type="nucleotide sequence ID" value="XM_035442287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GXI1"/>
    <dbReference type="GeneID" id="100763317"/>
    <dbReference type="KEGG" id="cge:100763317"/>
    <dbReference type="CTD" id="119865011"/>
    <dbReference type="OrthoDB" id="20799at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF39">
        <property type="entry name" value="[F-ACTIN]-MONOOXYGENASE MICAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMERB" evidence="3">
        <location>
            <begin position="692"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="767"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035298178.1"/>
        </source>
    </evidence>
    <sequence length="853" mass="95457" checksum="ADD0FBA88953D8FA" modified="2023-06-28" version="1">MLGGAICSAISIGTILSADEPTSPKKPKSVPEPTPRDMEPEVTSPQPSEWTSVRIGPEENVVGQDVLAVRVLVTSEDSSSDTESDYGDTRALCAKACEERPQLPESPPPSKPPTRHVSLREPLTRPVSLQYHEEPQNQSALLRTHSLQSPVPSKYQNWRRKFQSSSTSMNRRTPSPPLPPSFSSSSSLSSSFSSISEPGHTSDNSSPPQVPAYNLHSLPVSRGGDCSPTPLYLRRARALGMLKEIPLYLPHGPMLESTGLVSPAGESFSNCPEMASEDYQEAPAHLGSTKSMYEDFHPIAGKDQYLYNQNPTLRTARNPREVNMGPRRDQTGAPQPSEERKLGLKKLVLTPEQKTMLLDWSDSTPEHKAGKQFSQERDENGRSCTLKPFSSSPLPWAVKEKLLYQTGAQEEMHTPAIKAPREREVPPPKSPLRLIANAILKSLRPNSEGGKKTSPKPESKTSPRGQPHGFTRSFSLRKPSSNKDGDQQSPGRHMAFKKASAFFSLASPTSKTAQASDFSLPDPLLRSRSLPSRPYKMFFATTSPPPSSKIEDVPTLLEKVSLQDGTHFPKIRASRISNLGLKDKSFESFLQECKQRKDIGDFFTSPKEKGPPRNRVPSLEKLVQPLGSTSLGQVAHPSTGQDARLGALVTEATSSPSSTTSSSADEDFDSQLSSKLKRMPRRRRKLERKLVRQEELKRLHKAQAIQRQLEEVEERQRTLEIQGVKLEKVLRGEADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELELEDQQSRLEQKLRQKMLKDEGQKDENDLKEEKEIFKEMMQVIEQRNKLVDSLEEQRVKERTQDQHFENFVLSKGCQLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GXR6</accession>
    <name>A0A9J7GXR6_CRIGR</name>
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        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like isoform X2</fullName>
        </submittedName>
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        <name evidence="4" type="primary">LOC100754048</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035299035.1">
        <property type="nucleotide sequence ID" value="XM_035443144.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754048"/>
    <dbReference type="KEGG" id="cge:100754048"/>
    <dbReference type="OrthoDB" id="10049211at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="33"/>
            <end position="326"/>
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            <begin position="397"/>
            <end position="417"/>
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    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035299035.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="45493" checksum="38DC3ACB1AC37971" modified="2023-06-28" version="1">MAAQRWSLLQSEQQLSWMDGLLLCHLSGVGSASIHSYSTNGKGTESHPHEDNWLKFRSKNNCFLYGVFNSYDGNQVTNFVAQRLSAELLLGQLNTEHAXANVQQVLLQAFDVVERSFLESIDDALAKKESLQSQLPEGVPQHQLLPQSDKVIERLKALEREISGGAMAIVAALLNKLYVANVGLDAGKFKQVGIICGQENTRHIGDYRVKYGYTDIDLLSVAKAKSIIAEPEIHGAQPLDGIXGFLVLMSEGLYKALEAAHGPGQANEEIAAMIDIEFAKQTSLDVVAEAVMDRIKYIHCDIFASGGECAKLCPQLEDMTLMVRNFGYPLGEMSQPTPTPVPGGRVYPVSVPYSSAQNTSKTSVKFSLVMPSRGQMINGSHSSSTLDKAISILTNQSPTLPLQSTNTHTQAEHQLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GYJ3</accession>
    <name>A0A9J7GYJ3_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">Translation initiation factor IF-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC118238882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035301454.1">
        <property type="nucleotide sequence ID" value="XM_035445563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GYJ3"/>
    <dbReference type="GeneID" id="118238882"/>
    <dbReference type="KEGG" id="cge:118238882"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035301454.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="28563" checksum="C03D79F0FF9AE70A" modified="2023-06-28" version="1">MEAASFPCASVCPTQAGAKSFERWVTGLGRGTGTRTPSQTQSPPEARWQGSGAALRSPAPAHARHQGRGRPAWGPPAARCPLPAALPGTPGLPDSLPPSLSARRKEPRATGEALAGPQSRRPRAPSSPLRGERASERASTARQERSPAAGHPAPAAHPGVPGVDPSRRCPSLCSRPAGLPAYMARECPGCGAVTIGEPGSPPLASRSWQREGTGRVPPRRELRGGERARNLSAAVPREGAGAVSEVGRRKGPPAAKWRQMLLLEDLPWGTRPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZK9</accession>
    <name>A0A9J7GZK9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand calcium-binding domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Efcab10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035300840.1">
        <property type="nucleotide sequence ID" value="XM_035444949.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317720.1">
        <property type="nucleotide sequence ID" value="XM_035461829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GZK9"/>
    <dbReference type="GeneID" id="100758222"/>
    <dbReference type="KEGG" id="cge:100758222"/>
    <dbReference type="CTD" id="100130771"/>
    <dbReference type="OrthoDB" id="10260455at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22976">
        <property type="entry name" value="DD_EFCAB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049760">
        <property type="entry name" value="DD_EFCAB10"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035300840.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12166" checksum="6716E12F42332EF9" modified="2023-06-28" version="1">MELLNQLTSFLLFVRPKKPREYLISLLERLRIAKVTGVTFPFFMDNSNIVSMFEMMDSSGRGCISFVQYKEALKNLGLCTADEVLNDDGNLITLDKFRDEVCSLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H253</accession>
    <name>A0A9J7H253_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">Small EDRK-rich factor 2-like</fullName>
        </submittedName>
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        <name evidence="3" type="primary">LOC103161265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035303259.1">
        <property type="nucleotide sequence ID" value="XM_035447368.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314892.1">
        <property type="nucleotide sequence ID" value="XM_035459001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H253"/>
    <dbReference type="GeneID" id="103161265"/>
    <dbReference type="KEGG" id="cge:103161265"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035303259.1"/>
        </source>
    </evidence>
    <sequence length="43" mass="4852" checksum="562A985DBDD384CD" modified="2023-06-28" version="1">MKTQSDSVKGKCQDDGLSAAKQRDSEIIQQKQKKANEKKEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H5F6</accession>
    <name>A0A9J7H5F6_CRIGR</name>
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        <submittedName>
            <fullName evidence="9">Carcinoembryonic antigen-related cell adhesion molecule 19 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ceacam19</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily. CEA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305374.1">
        <property type="nucleotide sequence ID" value="XM_035449483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H5F6"/>
    <dbReference type="GeneID" id="100750495"/>
    <dbReference type="KEGG" id="cge:100750495"/>
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    <dbReference type="OrthoDB" id="9048100at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050831">
        <property type="entry name" value="CEA_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427:SF21">
        <property type="entry name" value="CEA CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039948586" evidence="6">
        <location>
            <begin position="33"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="7">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035305374.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29634" checksum="50C1BB74352320B7" modified="2023-06-28" version="1">MEIRPRTPGCFPKGLLFSALMLILWLPQGSQAALHIQKIPEQPQKSQDLLLSLHGVPSTIQDFIWYLGEEANGGTRLFSYIPGLPRPQRDGSAMGQRDIVGFPNGSMLLRGAQDSDSGTYQVAVTINPSWTMKAKTEVQVADTREYSVTGHLPANAGIMAATIIGSLAVGSLLVGGIAYLLVTRRRKGRSPRIPATEQPELSTSPDSGDSNIYEVMPSPVFLVSPISDTEPVNLAMVSPSLSPLPPQQPQPQNQHYQDLLNPDPAPYCQLVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H795</accession>
    <name>A0A9J7H795_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Paternally-expressed gene 3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100763909</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305204.1">
        <property type="nucleotide sequence ID" value="XM_035449313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763909"/>
    <dbReference type="KEGG" id="cge:100763909"/>
    <dbReference type="OrthoDB" id="9531386at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="paternally-expressed gene 3 protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="paternally-expressed gene 3 protein"/>
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        <property type="entry name" value="Paternally-expressed gene 3 protein"/>
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        <property type="entry name" value="paternally-expressed gene 3 protein isoform X1"/>
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        <property type="entry name" value="paternally-expressed gene 3 protein-like"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF189">
        <property type="entry name" value="ZINC FINGER PROTEIN 544-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="435"/>
            <end position="462"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="521"/>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="852"/>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1051"/>
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            <begin position="1172"/>
            <end position="1199"/>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1231"/>
            <end position="1259"/>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1472"/>
            <end position="1495"/>
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        <location>
            <begin position="1531"/>
            <end position="1555"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="1348"/>
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            <begin position="7"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00061988"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035305204.1"/>
        </source>
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    <sequence length="1555" mass="175569" checksum="4388F42983089900" modified="2023-06-28" version="1">MYHQEDDTNSDMTSDDDMSRTGRETPPPRSSHSFSSDRDQERRGRSREVEPRDRWPYNRNPRSRLPQRDLSLPVMSRSHFGLERDDDRRSLDYESRSQDAESYQNIVDRNEDKSPQNPIQDNLENYRKLLSLGVQLAEDDRHSHMTQGHSSRSKRSAYPSTSRGLKPMPEGKKPAHRRGICEEESSHGVIMEKFIKDVSRSSKSGRAREPNERPPPRFPRPSDNWKDSSSTKRESVIQERAPEAGTFRGAFRVNTELLSRSRALERKRRYHFESDDKGHESKSCVRKKPFECGSEMRQAMSMGNVNSAPSTDAQPIDPLGADPYVCDECGRSFGVISEFVEHQIMHTRENLYEYGESFIHSVAVNEVQKGQGGGKRFECKECGETFRRSAALAEHRQTHAREYLAEGRDQDDEDAVMPSPTFSELQKMYGKDKFYECKVCKETFLHSSALIEHQKTHGRGNPGDDERQRERERMRARAREQREQREREREREREREREREPFLTCPNFNEFHNMYRKEKFYECKVCGESFLHLSSLREHQKIHTRGNPFENKNRACEETFVPSQALKRRQKTYREKLFEFNNARDALMDGAGPGDHHKNRPRKSFFEGRAFEKPFTESHKSHTITRPPENKDEDKPFTISANPNDKPKPPAAEGGSQGKPFQRSVIRGALGFTKPKPVAESSTQTSGVFTHPRALSAASAYDGKDYKGSLIHSLPVPRALKRHRASGQGECSSDDGEPSIYMPDLTSKRRKIPGAGEDAYTGSSSLGLGLGLGRRDPILPIVPRAEPPTLSAESRDSSQDVTFSVPSSSVREHQKARAKKKYMEPRSNETSVIHSLGPFGDLQAIRRRPKIFECQECGEAFARRSELIEHQKIHDREGPSGSRLFERSVIRGRSRSLVPGDPQTSYAQERFVQEQVRKFRAFAQRSATSNSLGVQKIYNQEKYYAEEPHGKDTLGHKSHDTEPQGQKPHGDEPQDQEMRSSEEARGDQPHGQEPHGDEPQDQEPQDQEMRNSSDEPRGDEPHGQQSPRQAPASGSNEHERHRHDDVGDTIYECQDCGLGFADLSDLTSHQDVHSRKSLVDSREYAHSEVHAHSLGEFEKKFSGEKLYECPKCGESFTHSSLLFEHQRIHEQDQLHSSSAKTSDDGLVALMPARPRRNRGNEASTAAVSGSAIRCRQCGQGFIHSSALNEHMRQHRDEEAAAMEQGELAEDMFIQGLALTEYQGSETEEKLFECTVCGECFFTAKQLGDHHTKVHKDEPYEYGPSYTHASFLTEPLRKRMPLYECKDCGQPFLDDTVIDERMVFHRQREREQERDRDGSDIVAAPAARDGEANALVPQEALRIQGSNAEMAEPEVEAAEPEVEAAEPEVEAAEPDGEAEGPEGEAAEPDGEAEQPNGEAEQPNGEADEPDGAGIEDPEERAVAAAAAASDDDDEPEDEVEEPEGDADEPDVADLEDPEEEGEDQEIEVEEPYYNCHECTETFATSAAFGEHLKSHASVIIFEPANAPGECSGYIEHASTSAGGAEQADDKYFKCDVCGQLFHDRLSLARHQNSHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H9C4</accession>
    <name>A0A9J7H9C4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Large ribosomal subunit protein eL37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">60S ribosomal protein L37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100772666</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307094.1">
        <property type="nucleotide sequence ID" value="XM_035451203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772666"/>
    <dbReference type="KEGG" id="cge:100772666"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF22">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035307094.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11034" checksum="35940559AAA07CEF" modified="2023-06-28" version="1">MTKGTSSFGKSRNMTYTLWRRCGSKAYHLQKSTXGKCGYPAKCKRKYNWSAKAKRRNTTGTGRMRHLKIVYRRFKHGFREGTALKPKRAAVAASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H9W7</accession>
    <name>A0A9J7H9W7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hepcidin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100757672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hepcidin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305366.1">
        <property type="nucleotide sequence ID" value="XM_035449475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H9W7"/>
    <dbReference type="GeneID" id="100757672"/>
    <dbReference type="KEGG" id="cge:100757672"/>
    <dbReference type="OrthoDB" id="9428792at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of iron ion transmembrane transport"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEPCIDIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06446">
        <property type="entry name" value="Hepcidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0372">Hormone</keyword>
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    <keyword evidence="3" id="KW-0964">Secreted</keyword>
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    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039950470" evidence="7">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035305366.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15789" checksum="C3F8B4813734CC65" modified="2023-06-28" version="1">MAQSTKIQAACLLLLLIASLASSTLLQQLVSIPGLPRWESRPPGRQGLLSYSGQLLKGRGLHRSSQGVLLKLPVNDHLENSYLWVRQPEALQPQHRTKAQTDRTDRTLLIPKRTKRDSHFPICIFCCYCCGNFKCGVCCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HA11</accession>
    <name>A0A9J7HA11_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable G-protein coupled receptor 174</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17 18 19" type="primary">Gpr174</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16 17 18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16 17 18">17A/GY</strain>
            <tissue evidence="16 17 18">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with GNA13. Interacts with CCL21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007646342.1">
        <property type="nucleotide sequence ID" value="XM_007648152.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007646343.1">
        <property type="nucleotide sequence ID" value="XM_007648153.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007646344.1">
        <property type="nucleotide sequence ID" value="XM_007648154.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007646345.1">
        <property type="nucleotide sequence ID" value="XM_007648155.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306143.1">
        <property type="nucleotide sequence ID" value="XM_035450252.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306144.1">
        <property type="nucleotide sequence ID" value="XM_035450253.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306145.1">
        <property type="nucleotide sequence ID" value="XM_035450254.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306146.1">
        <property type="nucleotide sequence ID" value="XM_035450255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HA11"/>
    <dbReference type="GeneID" id="100756360"/>
    <dbReference type="KEGG" id="cge:100756360"/>
    <dbReference type="CTD" id="84636"/>
    <dbReference type="OMA" id="YLFLMHP"/>
    <dbReference type="OrthoDB" id="9435792at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15152">
        <property type="entry name" value="7tmA_GPR174-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000167">
        <property type="entry name" value="probable G-protein coupled receptor 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047836">
        <property type="entry name" value="GPR174_7tmA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF86">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 174-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="36"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035306143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035306144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035306145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035306146.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38848" checksum="803F4ECDA2AA1B55" modified="2023-06-28" version="1">MIDNYTCNKTEGDNIDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPTRNVNLAQSVAMITIGELVGFVTPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPIIYYFTTNEFRRRLSRQDLPESIQLHTKSYKIVSNHTTSTMGTDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCK8</accession>
    <name>A0A9J7HCK8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">POTE ankyrin domain family member A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC113839063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035309762.1">
        <property type="nucleotide sequence ID" value="XM_035453871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCK8"/>
    <dbReference type="GeneID" id="113839063"/>
    <dbReference type="KEGG" id="cge:113839063"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050657">
        <property type="entry name" value="Ankyrin_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147:SF73">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY, MEMBER G LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035309762.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50495" checksum="65494CD34912E91F" modified="2023-06-28" version="1">MLSTLRMVSCFKKQQTPQNFFKSSASGTNNSCCWCSTQEETYRQPYEAKNKFHLSACKGKMNVILKLLEKKKYSIHHTDKKQRTALHFASYHGRTTVVQFLLLSGCGINVLDDKMMTPLVKAIQSVERDTVSLLLQEHADPNLKDIYGQTALHHAIRNDTPSIVAALLDSGCNMEEPSKEGLTPLMLALQQNKLMAAAFLITSGANVHLFDQHLRTTLMFAVKWDSEHLVRLLLKKGVDLWSVDIFGWNALDYAHAGNRKVVKILESECGKTCTTYPSSTYMNPATEDHKEEKEHSDSKSAPIENPDLDVDSGHTGPQPKMENQVEALHRYKSEEGAKPSVPDPEEVCRQTTDLDLKPLFNAYQRGKAGFCKLLSSLSSLSSIGFGDITTWKEGVFLKELIQFRRQNFDQPTQTFHLFLHLSSLRIYLVLSFPIIILWCLLTNFPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HD75</accession>
    <name>A0A9J7HD75_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Retinoic acid receptor beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nuclear receptor subfamily 1 group B member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Rarb</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307698.1">
        <property type="nucleotide sequence ID" value="XM_035451807.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308029.1">
        <property type="nucleotide sequence ID" value="XM_035452138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HD75"/>
    <dbReference type="GeneID" id="100768698"/>
    <dbReference type="CTD" id="5915"/>
    <dbReference type="OrthoDB" id="6081310at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002068">
        <property type="term" value="P:glandular epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003417">
        <property type="term" value="P:growth plate cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061037">
        <property type="term" value="P:negative regulation of cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003148">
        <property type="term" value="P:outflow tract septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048384">
        <property type="term" value="P:retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001657">
        <property type="term" value="P:ureteric bud development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055012">
        <property type="term" value="P:ventricular cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06964">
        <property type="entry name" value="NR_DBD_RAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06937">
        <property type="entry name" value="NR_LBD_RAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000073">
        <property type="entry name" value="Retinoic acid receptor beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000004">
        <property type="entry name" value="Retinoic acid receptor beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047159">
        <property type="entry name" value="NR_DBD_RAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047158">
        <property type="entry name" value="NR_LBD_RAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003078">
        <property type="entry name" value="Retinoic_acid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF5">
        <property type="entry name" value="RETINOIC ACID RECEPTOR BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01292">
        <property type="entry name" value="RETNOICACIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
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            <end position="160"/>
        </location>
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        <location>
            <begin position="183"/>
            <end position="417"/>
        </location>
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        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="415"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00039627"/>
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            <dbReference type="ARBA" id="ARBA00042231"/>
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        <source>
            <dbReference type="RuleBase" id="RU004334"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51843"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035308029.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50513" checksum="04C7B6358AEBC34A" modified="2023-06-28" version="1">MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSVSPSSVENSGVSQSPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HER0</accession>
    <name>A0A9J7HER0_CRIGR</name>
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        <recommendedName>
            <fullName evidence="5">V-ATPase 14 kDa subunit</fullName>
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    <gene>
        <name evidence="7" type="primary">LOC118239696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
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    <dbReference type="RefSeq" id="XP_035308954.1">
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    </dbReference>
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    <dbReference type="GeneID" id="118239696"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035308954.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12115" checksum="C2225F9DBBED5FBF" modified="2023-06-28" version="1">MDDKVTLEYQRDAGHSTATPSDFLVVEKDTTINKIEDTFRQFPNRGDIGIILINQYIAEMVWHTLDPHQRSIPAVLEIPSKEHPYNAAKDSILHRAKGMFTAKDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HFD9</accession>
    <name>A0A9J7HFD9_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">GRB2-associated-binding protein 2-like</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="primary">LOC113838354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="80"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035309432.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18387" checksum="A4FDA45D416E5A4F" modified="2023-06-28" version="1">MPLHIASRGSDIQPPPVYCHLKPGQKAKPEPRDLRNNTVINELPFKSPVTKPWSTVNNTFNRSSSQYCRSISITDSGDCEEKYVPMQNPMSSSPVPSGTNNPAPKKSTGNVNYIDPDFQLPSPSPQHKPSTSSVTSDEKGEYVQIDEEKNQALQKSIQESTKMQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HFV2</accession>
    <name>A0A9J7HFV2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A3-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100751639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035308938.1">
        <property type="nucleotide sequence ID" value="XM_035453047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751639"/>
    <dbReference type="KEGG" id="cge:100751639"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF137">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE 2A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035308938.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41660" checksum="DB4BE4F7F382E0D7" modified="2023-06-28" version="1">MEGHVTASEKWVMAVFVVQLCCDGYGLCGKVLVWPCDMSHSLTXILEELVDRVHEVTVLKYPTIMIDQNKHSALHFENICLSNGEEASKIHINELVNLAVNVIPNLPVWRGATNFQEFFFHLTSIFQNICWSVLYNQTFMNELQDTKYNVMVIDPVVPCGELVAEVLQVPFVNTLRFSIGYTLEKYCGQLPVPLCXCIMGELTENMTFTERVINMILSLFFEFGLQQYDFAFWDKFYSKTPGKHTTLAETIGKAEMWLIRSYWDLEFPRPTLPNVEYVGGLHCKPANPLPKEMEDFVQSSGEHGVVVFSLGSMVSNMTEEKANTIAWALAQIPQKKQIFIADATIPQKVPLTESNLDISTVITVHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J5S5</accession>
    <name>A0A9J7J5S5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Plcl2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027250367.1">
        <property type="nucleotide sequence ID" value="XM_027394566.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J5S5"/>
    <dbReference type="GeneID" id="100771671"/>
    <dbReference type="KEGG" id="cge:100771671"/>
    <dbReference type="CTD" id="23228"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050811">
        <property type="term" value="F:GABA receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16223">
        <property type="entry name" value="EFh_PRIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08597">
        <property type="entry name" value="PI-PLCc_PRIP_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000017">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000001">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028382">
        <property type="entry name" value="PLCL2_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF84">
        <property type="entry name" value="INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="621"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="737"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1103"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027250367.1"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126087" checksum="54FFBAD02775D149" modified="2023-06-28" version="1">MAECGRGAAGEALPTSPGPALGAKGALKAGAGEGGGGGGGTGGRLVHGRARYDSGGVSNGDCSLGVSGDEARASPARGPRGVALARTPSPAAGPVPRDSKQGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDDLGHITLCNAVQCIRNLNPGLKTSRIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGCLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEIVEQPNQLPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDMMMQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHYAAVSCGLNKPGTENSEAQKPRRSLEVIPEKASDENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J8A3</accession>
    <name>A0A9J7J8A3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Insulin-like growth factor-binding protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">MAC25 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Igfbp7</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear. Interacts with CD93; this interaction plays a role in endothelial cells angiogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027246764.1">
        <property type="nucleotide sequence ID" value="XM_027390963.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J8A3"/>
    <dbReference type="GeneID" id="100757355"/>
    <dbReference type="KEGG" id="cge:100757355"/>
    <dbReference type="CTD" id="3490"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:insulin-like growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Insulin-like growth factor binding protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000026">
        <property type="entry name" value="Insulin-like growth factor-binding protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.40.20:FF:000006">
        <property type="entry name" value="insulin-like growth factor-binding protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
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        <property type="entry name" value="IGFBP_rP_mac25"/>
    </dbReference>
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        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018239">
        <property type="entry name" value="IGFBP_rP_mac25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0691">RNA editing</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039932242" description="Insulin-like growth factor-binding protein 7" evidence="15">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="17">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="18">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027246764.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="28881" checksum="95F955CB698CC5D8" modified="2023-06-28" version="1">MERLPRALLLGSAGLLLLLLPLSSSSSSDACGPCVPASCPALPPGGCPLGETRDACGCCPVCARGEGEPCGGGAAGRGHCAPGMECVKSRKRRKGKAGAAAGGPAVLAVCVCKSRYPVCGSDGTTYSSGCQLRAASLRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAKVYLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGEASASAKITVVDALHEIPVKKGQGAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JCL6</accession>
    <name>A0A9J7JCL6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM13C isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Fam13c</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM13 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027395107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JCL6"/>
    <dbReference type="GeneID" id="100761386"/>
    <dbReference type="KEGG" id="cge:100761386"/>
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    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059029">
        <property type="entry name" value="FAM13A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF19">
        <property type="entry name" value="PROTEIN FAM13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26116">
        <property type="entry name" value="FAM13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM13A-like" evidence="4">
        <location>
            <begin position="528"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007549"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027250908.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="67441" checksum="02B4EAC9D59909DE" modified="2023-06-28" version="1">MFSCFCFSLQDNSFGSAAVTECEEDTVSLHEDEDNCSGLRDENNKENYPQVGARIDELAPPSHEAQQHVEQTLLVDGVLRPSMGNFKSRKPKSILRAESGRNHGESQDAEHVVPSQAECQGRAGTPAHESPQNSIVRSQETVRLQPRVDQRAAIWPKDAFGTQQDFHENSLLKLQALESDLCSAFLTNQEEDGQVHGVKDPAPASTQSVPADGGVDSAAPMPTHKDGQSDADGTPEDLQSAGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPSSQQFMMPRSSSRCSGGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSTPKGPRRNLSCEQPPVPRENGKLEAVGPEPSSSGEETSDAVMMEKRDQIAPQDDVKVTKQDKNLIKPLYDRCRIIKQILSTPSLIPTIQEEEDSDEDCPQRSQPPSLPDPVSRLPVGDHLTYSETEPMRTLLPDEKKEGKQPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDRMPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JE19</accession>
    <name>A0A9J7JE19_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurochondrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">Ncdn</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4 5">17A/GY</strain>
            <tissue evidence="4 5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurochondrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007639798.1">
        <property type="nucleotide sequence ID" value="XM_007641608.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255105.1">
        <property type="nucleotide sequence ID" value="XM_027399304.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295499.1">
        <property type="nucleotide sequence ID" value="XM_035439608.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310745.1">
        <property type="nucleotide sequence ID" value="XM_035454854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JE19"/>
    <dbReference type="GeneID" id="100766879"/>
    <dbReference type="KEGG" id="cge:100766879"/>
    <dbReference type="CTD" id="23154"/>
    <dbReference type="OrthoDB" id="8186546at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027255105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035295499.1"/>
        </source>
    </evidence>
    <sequence length="761" mass="82553" checksum="241C62898DC5AFEB" modified="2023-06-28" version="1">MSSSLPVCPHHSLPMCLLERDKTRCLSPAAAEQWGQLLPTSLLLGKAGIMASDCEPALNQAESRNPTLERYLGALREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALGVALLACFCSDPELASHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQRAEDASKFELCQLLPLFLPPTTVPPECHRDLQAGLARILGSKLSSWQRNPALKLAARLAHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVVTACYALMELGIQECTRCEQSLLKEPQKVQLVSIMKEAIGAVIHYLLQVGPEKQKEPFVFASVRILGAWLAEETSSLHKEVCQLLPFLVRYAKTLYEEAEEANDISQQVANLAISPTTPGPSWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPDYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JEY2</accession>
    <name>A0A9J7JEY2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Interferon alpha-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100750928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha/beta interferon family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003497125.1">
        <property type="nucleotide sequence ID" value="XM_003497077.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256316.1">
        <property type="nucleotide sequence ID" value="XM_027400515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JEY2"/>
    <dbReference type="GeneID" id="100750928"/>
    <dbReference type="KEGG" id="cge:100750928"/>
    <dbReference type="OrthoDB" id="9833506at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000001">
        <property type="entry name" value="Interferon alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000471">
        <property type="entry name" value="Interferon_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691:SF60">
        <property type="entry name" value="INTERFERON ALPHA-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691">
        <property type="entry name" value="TYPE I INTERFERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00143">
        <property type="entry name" value="Interferon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00266">
        <property type="entry name" value="INTERFERONAB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00076">
        <property type="entry name" value="IFabd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00252">
        <property type="entry name" value="INTERFERON_A_B_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3 8" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027256316.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24075" checksum="D74A00033F14B71A" modified="2023-06-28" version="1">MGRELPECGTRQSMVHKSCGAWSPGPSEVWVLWSLLQRCCDKKNPYSLRSLQKKREKNLTSGAVIPVGAPHAALAYADGCKATRDFAFLLEKVDVQHIQKAQAIPVLQELTQQVLILFSSKDSSAAWETTLLDTFCTGLHQHLSDLQACLMQQVGEQEPPMSQEDSLVAVRKYFHRITVYLREKNHSPCAWEVVRAEVWRALSASGNMLLGRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JG34</accession>
    <name>A0A9J7JG34_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat and protein kinase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ankk1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027268117.1">
        <property type="nucleotide sequence ID" value="XM_027412316.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JG34"/>
    <dbReference type="GeneID" id="100751636"/>
    <dbReference type="KEGG" id="cge:100751636"/>
    <dbReference type="CTD" id="255239"/>
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    <keyword evidence="7" id="KW-0418">Kinase</keyword>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JIV1</accession>
    <name>A0A9J7JIV1_CRIGR</name>
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        <submittedName>
            <fullName evidence="12">Protein patched homolog 1 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Ptch1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PATCHED HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="456"/>
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            <begin position="1013"/>
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            <begin position="1040"/>
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            <begin position="1069"/>
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        <location>
            <begin position="1107"/>
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    </feature>
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        <location>
            <begin position="1139"/>
            <end position="1164"/>
        </location>
    </feature>
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        <location>
            <begin position="424"/>
            <end position="584"/>
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    </feature>
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        <location>
            <begin position="1"/>
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            <begin position="1175"/>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1204"/>
            <end position="1213"/>
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        <location>
            <begin position="1288"/>
            <end position="1297"/>
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    </feature>
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        <location>
            <begin position="1334"/>
            <end position="1353"/>
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    </feature>
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        <source>
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    </evidence>
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        </source>
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    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027265457.1"/>
        </source>
    </evidence>
    <sequence length="1434" mass="159261" checksum="A683BA698308887E" modified="2023-06-28" version="1">MASAGNAAGALGRQAGGGRRRRTGGPHRAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLHKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSARALQTMFQLMTPKQMYEHFRGYEYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHSNTRYSPPPPYSSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSNVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVRFAVPPGHMNNGSDSSDSEYSSQTTVSGISEELRHYEAQQGSGGPGHQVIVEATENPVFARSTVVHPESRHHPPLNPRQQPHLDSGSLSPGRQGQQPRRDPPREGLRPPPYRPRRDAFEISTEGHSGPSNRDRSGPRGARSYNPRNPTSTAMGSSVPSYGQPITTVTASASVTVAVHPPPGPGRNPRGGPCPGYESYPETDHGVFQDPHVPFHVRCERRDSKVEVIELQDVGCEERPWGSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JK84</accession>
    <name>A0A9J7JK84_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100762766</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cell membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263755.1">
        <property type="nucleotide sequence ID" value="XM_027407954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JK84"/>
    <dbReference type="GeneID" id="100762766"/>
    <dbReference type="KEGG" id="cge:100762766"/>
    <dbReference type="OrthoDB" id="6144223at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13954">
        <property type="entry name" value="7tmA_OR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000024">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050939">
        <property type="entry name" value="Olfactory_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242:SF253">
        <property type="entry name" value="OLFACTORY RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 14 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="46"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027263755.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35693" checksum="69BD7F98A4FBA0BD" modified="2023-06-28" version="1">MENKACNGSGDSQTIFYLTGIPSLQKYLFLPVFFLFLLFYLLILVGNTLILVAVVTEPSLHKPMYFFLINLSALDILFTTTTVPKMLSLFLLGDRFLSFPACFLQMYLFHSFSCSEAFILVVMAYDRYVAICRPLHYPVHMTPQTNTALAASAWITALLLPIPAVVQTSQMAFGSIAYIYHCFCDHLAVVQASCSDTSPQTLMGFCIAMVVSFLPLLLVLLSYAHILASVLRINSKEGRSKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFHIMGNVVYAILTPVLNPLIYTLRNKDVKAAITKMTCHQDPRNVGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JLE2</accession>
    <name>A0A9J7JLE2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Myosin-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Myh15</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269159.1">
        <property type="nucleotide sequence ID" value="XM_027413358.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100758646"/>
    <dbReference type="KEGG" id="cge:100758646"/>
    <dbReference type="CTD" id="22989"/>
    <dbReference type="OrthoDB" id="10258119at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14929">
        <property type="entry name" value="MYSc_Myh15_mammals"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF26">
        <property type="entry name" value="MYOSIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="16">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="82"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1574"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="840"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1374"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1627"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1574"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027269159.1"/>
        </source>
    </evidence>
    <sequence length="1925" mass="221155" checksum="F44F70BA39A2E24E" modified="2023-06-28" version="1">MDLSEFGDAAAFLRRNTDDSLLQSPAFDGRKKCWVHDGKNAYIEAEVKESVGDGKVIVETRDGESLRIKEDKIQQMNPAEFEMVEDLSMLLHLNEPSVLHTLRTRYDHWMIYTYSGLFCVAINPYKWLPVYEKEVMAAYQRKKRSKVPPHIFAVANSALQDMLRSGKNQSILFTGESGAGKTINTKLTIQYFATMAAITEPKKKLGISEDQIVQMNPVLEAFGNAKTLRNDNSSRFGKLIRMHFDARGTLSSADIQIYFLEKSRVVYQQPGERNYHIFYQILSGKQELQDMLLVSTNPSDFHICSCGVVAVESVDDAKEFLATEKAIDILGFLPDEKFGCYKIIGAIMHIGNLKFRQNPREEQLEADGTENADKAASLMGINSSELVKGLIYPRIKVGNEYVTRSQNIQQVTYAVGALSKSIYERMFKWLVARMNQVLDTKLSSHFFIALLDITGFEILDYNSLEQLCINLTNEKLQQFFNQHMFILEQEEYRKEGLGWIAIDYGLDLQAFIDLIEKPMGIFSILEEECMFSKATDKTFETKLFDSHFGKSPYFQKPTSAEKSYAVHFELAHYAGVVPYNISGWLGKNKDILNETVVAVLQKSSNKVLASLFTNDIISGSATQFGEKTRRKGTSFQLISSLHKENINKLMTDLKSTAPHFVRCINPNMNKMPGVLDPFLVLQQLRCNGVLEGIRVCCEGFPIRMLYDDFKQRYCILNPRIFSKTEFVSSRKATEGVLGFLEVDNSQYQCGVTKVFLKTNILDQLEERRDEKISKVFTLFQARARGRLMRITFQKILDERDALVLIQENIRAFMAVKNWPWMRLFFKIKPLAKSVGFGKEITGLKEECAQLQKALESSESQRDELTTKQVSLVQEKHDLLLKLQAEQETLANAEEQCESLIKSRMELEARVKELSGRVEEEEAINSELTARGRKLEDECSELKKEIYDLETILAKSEKEKCAAEHKVRILTEEVHSLNEEVSKLTRAVKAAQEAQHQTQEHLHMEEEKLSNMSKASLKLGQQVDVLEGALERERKARMKCEREKLKLEGELKVNQEGAENLESSRWQLVEQLRKKEFEIGQMNSKVESEKNLVSQLQVMVKELQAHILNLKEELENERATRAKVERERADLTQDLEDLKERLEEAGGTSLAQMEITKHQEERFQKLRHDMEETTRQFEATSASLKKRHAENLAELEGQVEHLQQARQVLEQEKSDLHLQVDDLLTQVDQMARTKANAEKLCSGYERRLNEANTKLDEATRLANDLTTQNMKLQSESGEFLKRLEEKETLISQLSREKSNLTQQIEELRGQLEEETRCQSALAHALQSAKHDYDLLREQYEEEQEVKTGLHRALSKGNKETVQWRMKYEHDAIQRTEDLEEAKKKLAIRLQEAAEAMEVANARNASLERARNRLQVELGDALSDLGKARSVVATLEQKQQHSEKALAAWKQKQEEAQALLQASQKEARALSTEVLMLRHACEESTEAQETLRRQNQVFQEQICSLTNQVREGIKNLAEVEKAKKLIEQEKTEAQVTLEETEGALERNESKILHFQLELSEAKAELERKLLEKEEETEKLREKHEQALGSLQSSLDSEASSRIEATRLRKKMEGDLKEVEIQLCAANRQVSQTARALGQLQSQLKDLQQQLDDSTYQNKDLKQQVAVAEQRNTLLQSELEELRSLQEQTERGRKLAEKELLEATERIHLFHSQNKGLLSQKKKLEADVAQMQKEAEELLQGCQKAEEKAKKAAAEASNTLEELKKEQDTNAHLQKMRKNMEQTIKDLQKRLDEAEQTTVLGSKKQIQKLESRVRDLEGELEGELRRSAEAQREARRLERCIKELTYQAEEDKKYLSRMQALSDKLQLKVQSYKQQVEAAEAQANQYLSKYRKQQHELNEVKERAEVAETQVNKLKAKVKEFERKVREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JMQ9</accession>
    <name>A0A9J7JMQ9_CRIGR</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC103159818 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC103159818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
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    <dbReference type="GeneID" id="103159818"/>
    <dbReference type="KEGG" id="cge:103159818"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027266027.2"/>
        </source>
    </evidence>
    <sequence length="189" mass="19707" checksum="DA434E8DB6033C00" modified="2023-06-28" version="1">MLGRPGLSTDRNEGAGVRGTVISVASHRIGGRPRPEARAAHPAPSGRNASPALPHARIRAHREGPGLAEELHGSSVCPLPRSPPLVAKKDGVGGPSFPACPASLPTPPWPGDSLHMPCSTAPGGGTGAAPAAEQDAQRKEGQQEEGSRSPLHCEETEGQRGRRHVNRSLPYQVHGISFKAVKVAAKWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JPW1</accession>
    <name>A0A9J7JPW1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine protease 44-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100770736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003506722.1">
        <property type="nucleotide sequence ID" value="XM_003506674.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270051.1">
        <property type="nucleotide sequence ID" value="XM_027414250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JPW1"/>
    <dbReference type="GeneID" id="100770736"/>
    <dbReference type="KEGG" id="cge:100770736"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF159">
        <property type="entry name" value="SERINE PROTEASE 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039919887" evidence="10">
        <location>
            <begin position="37"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="121"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027270051.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="41611" checksum="D7AB0772471DF5F1" modified="2023-06-28" version="1">MRRLRDGGQGLRGGMAFRGPLAWFLLLQMLLGEARMIPGTLSLPPLRLEDGLDDPSASPQEKPLTGMPEISRGPQPEGSMVPLDSVAFTPSHSVSPMTLSQERFPTWIPTTTGCGHRTARVVGGQLAAERKWPWQVSLQVRNTHVCGGSLISKWWVMTAAHCVFGHLNYVVSMGIVDLWTDQAVKIPVQDIVVHRDFSLLGTMVHDIALALLAFPVNYSGYIQPVCLPRRAFMVKAGTQCWVTGWGRVLEGGSSSRKLREVDLSIIHHEECNRILKKSSGKILTVVQEGVVCGYNEEGGDTCQGDSGGPLVCEFNGSWVQVGIVSWGIGCGRVGFPGVYTDVSYHRDWIVKELSRASGWNSPGFLILSTCLVIYLGMLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JRB8</accession>
    <name>A0A9J7JRB8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sialic acid-binding Ig-like lectin 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC103158791</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276659.1">
        <property type="nucleotide sequence ID" value="XM_027420858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JRB8"/>
    <dbReference type="GeneID" id="103158791"/>
    <dbReference type="KEGG" id="cge:103158791"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000829">
        <property type="entry name" value="Sialic acid-binding Ig-like lectin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF138">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039899603" evidence="13">
        <location>
            <begin position="17"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="231"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027276659.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42487" checksum="15BDD566311F818D" modified="2023-06-28" version="1">MLLLLLLLWGVKGVEGGPELLPGFILSVQREVVVQEGLCIFVPCEFHAREEWTDSDPIHGYWFRYGEHDSPVATNNPLRPALKETLGRFSLLGDPQKNNCSLDIRETRKEDTGTYFFRLERGKTKYNYLWNTMTLNVTALTNTPHMLIPETLEAGRPSNLTCSAPWACGSPTFSWTGSSVSLSSTNTTGSSVLTVIPQPWDHGTNLTCQVTLPGSGVTTGMTIRLNVSYAPKNLTMTIYKGVGSATTALRNGSTLTLLEGESLRMVCTVNSNPPARLNWAYENLILSPMQSPTSGLLELPQMHLRYEGKFTCSAQNVLGSQHMSLNLLLYRKPGLMAEVVLVAVVEAAVKVLLLGLCLIILRMTCLAQHGHSQIANPILNPCPCQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JT99</accession>
    <name>A0A9J7JT99_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein SWI5 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein SAE3 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Swi5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SWI5-SFR1 complex. Interacts with RAD51.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279418.1">
        <property type="nucleotide sequence ID" value="XM_027423617.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JT99"/>
    <dbReference type="GeneID" id="100754454"/>
    <dbReference type="KEGG" id="cge:100754454"/>
    <dbReference type="CTD" id="375757"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000056">
        <property type="entry name" value="DNA repair protein SWI5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027279418.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21725" checksum="34CF8959907C5735" modified="2023-06-28" version="1">MNDREAWSRCCQAGAAGGGVRLTPTLDPSEYKTTPIRVPRTSGFRRWARSAHFISPPFPDSPRLIPDFLLPGPSQPALRTIPFPRAELGFGRSCHGAFRSPCSSPKLEEDDEISEETLNSDIQKLKEKRDMLDKEISQLVKEGYRVGELEDHIALLHEYNDIKDVAQMLLGKLALTRGVTTKELYPDFGLDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUZ1</accession>
    <name>A0A9J7JUZ1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC107977725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276933.1">
        <property type="nucleotide sequence ID" value="XM_027421132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JUZ1"/>
    <dbReference type="GeneID" id="107977725"/>
    <dbReference type="KEGG" id="cge:107977725"/>
    <dbReference type="OrthoDB" id="9975554at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="32"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027276933.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33650" checksum="0FC458991D66709A" modified="2023-06-28" version="1">MQFVLVGFSDFPNLQEFLFAVFFIVYIIILIGNFLIIVVSSMDPALKKPMYFFLAHFSSLEICYVSVTIPRILYNIETQNRCISVMSCATQLCFFLIFGTTESLLLAIMAYDRYVAICNPLHYILIINPTKCTHMAVFSWLSGIPVQIGVTCQIFSLHFCSSNKIDHFFCDVPPILKLACGDTSVQELSVYVVDTVVAELPFILVLASYSKIMVTLLRLPTAKGRAKAFSTCSSHLMVVILFYGSGTVTYMRPKSMHSPGTDKLLSLFYTTVTPMFNPLIYSLRNKEVIAALKMLFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JXI9</accession>
    <name>A0A9J7JXI9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TOM1-like protein 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Tom1l2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TOM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283098.1">
        <property type="nucleotide sequence ID" value="XM_027427297.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JXI9"/>
    <dbReference type="GeneID" id="100754181"/>
    <dbReference type="KEGG" id="cge:100754181"/>
    <dbReference type="CTD" id="146691"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14238">
        <property type="entry name" value="GAT_TM1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16996">
        <property type="entry name" value="VHS_Tom1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000001">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000003">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027429">
        <property type="entry name" value="TOM1L2_VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF31">
        <property type="entry name" value="TOM1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="7">
        <location>
            <begin position="219"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027283098.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="57822" checksum="FFEAF250E8DF8B65" modified="2023-06-28" version="1">MEFLLGNPFSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLSGNRNYREVMLALTVLETCVKNCGHRFHLLVANRDFIDSVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGVEFPMADLDALSPIHTPQRSVPEMDPAATMPKSQSQPRTSAGTYPSPPPASYSALQAPALSVTGPITANSEQIARLRSELDIVRGNTKVMSEMLTEMVPGQEDSSDLELLQELNRTCRAMQHRIVELISRVSNEEVTEELLHVNDDLNNVFLRYERFERYRSGRSVQNASNGVLSEVTEDNLIDLGPGSPAVVSPMVGSTAPPSSLSSQLAGLDLGTESVSGTLSSLQQCKPHDGFDMFAQTRGNSLAEQRKTVTYEDPQAAGGLASALDNRKQNSDMSGKGGDCDLQPIDCWLMTQGMIPVVQPSVMDDIEVWLRTDLKGDDLEEGVTSEEFDKFLEERAKAAETVPDLPSPPTEAPAPASNTSNRKKPERSEDALFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K195</accession>
    <name>A0A9J7K195_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100769446</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_035293610.1">
        <property type="nucleotide sequence ID" value="XM_035437719.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035304703.1">
        <property type="nucleotide sequence ID" value="XM_035448812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769446"/>
    <dbReference type="KEGG" id="cge:100769446"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000203">
        <property type="entry name" value="Putative ras-related protein ral-a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035304703.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23521" checksum="F6E169810EFAAAF6" modified="2023-06-28" version="1">MAANKPKGQNSLALYKVVMVGSGGVGKSALTLQFMYEFVEDYEPNKADSYRKKVVLHGKEVHIDILDAAGQEDYVAVRDNYFRSGAGFLCVXSITKMEXFTATADFREQILRVKEDENIPFFLVGNKSDLEDKRQVSVEEAKKNRTEQWNVNYVETSAKTRANVDKVFFDLMREIRAKKMEDSKEKNGNKKRKSLAKRFGEKCCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K2X0</accession>
    <name>A0A9J7K2X0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sucrase-isomaltase, intestinal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Mgam</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose.</text>
            <dbReference type="EC" id="3.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action.</text>
            <dbReference type="EC" id="3.2.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">The resulting sucrase and isomaltase subunits stay associated with one another in a complex by non-covalent linkages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306801.1">
        <property type="nucleotide sequence ID" value="XM_035450910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769016"/>
    <dbReference type="KEGG" id="cge:100769016"/>
    <dbReference type="CTD" id="8972"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000005">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000016">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF63">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0765">Sulfation</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="21">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="21">
        <location>
            <begin position="923"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="21">
        <location>
            <begin position="1820"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="21">
        <location>
            <begin position="2709"/>
            <end position="2759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035306801.1"/>
        </source>
    </evidence>
    <sequence length="3613" mass="411736" checksum="69DD5A11ABAD1CB4" modified="2023-06-28" version="1">MARPRFKKFSKLELTLIVLLLVLFIIAVVLIVLLANSTPQNDTTVLRTSTPDSTSRTTPSHCPVLSEQERINCIPDKSPNKTICDQRGCCWDPQGAGNAICYFSKNHGYQMESDPVITNAGLTAQLKNLPSAPLFGSEIENVLLTAEYQTPNRFHFKFTDPTKDRYEVPHEHVQPFSGNAASSLNYRVEVFKQPFSIKVTRKSNNRVLLDTSIGPLLFSDQFLQLSTYLPSANVYGLGEHVHQRYRHDMNWKTWPLFSRDTTPNKDGNNLYGVQTFFLCLEDNSGLSFGVFLMNSNAMEVTLQPTPAITYRTIGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWALGFQLSRYDYGSLDNMKAVVDRNRAVQLPYDVQHADIDYMDQRKDFTYDPVKFSGFPEFAEDLHLNRQKLIIILDPAISNNSFPDDPYDPYDKGSAMNIWVNSSDGINPLIGEVWPGITVFPDYTNPNCAVWWAEEINSFHNKVKFDGIWIDMNEVSNFVDGSVSGCSTNDLNYPPFTPKILDGHLFSKTLCMDAVQYWGRQYDVHSLYGYSMAIATSEAVKATFPEKRSFIITRSTFAGSGKFAAHWLGDNSATWEDLQWSVPGMLEFNLFGIPMVGADICGFALNTTEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGADSLLLNSSRHYLNIRYTLLPYLYTLLYHAHSRGDTVARPLLHEFYKDNNTWDIDRQFLWGPGLLITPVLEEASEKVKAYLPDAIWYDYETGAQVTWRKQSIDMELPGDKIGLHLRGGYIFPTQQPDTTTADSRKNPLGLIIALDENKEARGELFWDDGETKDTVTKNTYIFSEFSVTQNHLNVTISSASYKDPNNLEFQEIKILGTQAIYNVKVKQNGVLSSMSPQITYNSNLKVATITDLHLVLGEPYTVEWSNMTDEEKIDCYPDEHGASEANCTARGCIWEESDTPGVPYCFFANGLYSVTDVQYQPDGATANVSLKDSPYSNAFPSTPVKQLQVQVIYHKNEMLQFKIYDPNDSRYEVPVPLNIPISPSSTTDGRLYDVLIKENPFGIEIRRKSTGTVIWDSQLLGFTFNDMFIRISTRLPSTHIYGFGETEHTSFKIDLNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLLNSNAMDVTFQPLPALTYRTTGGILDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDSEIASLYDEMVAKQIPYDVQYSDIDYMERQLDFTLSPKFSGLPDLISRMKKDGMRVILILDPAISGNETEPYPAFTRGLQEDVFIRYPNGGDIVWGKVWPDYPGIVVNSSLDWDSQVEQYRAYVAFPDFFRNSTVTWWKKEIEELHTNPQNSTKSLKFDGLWIDMNEPSSFVNGAVPPGCSDATLNRPPYMPHLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHSLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWAGHWLGDNTAAWDQLGKSIIGMMEFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDEAFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFLSDRETWNIDKQFLLGSSFLVSPVLEPNARNVTAYFPKAHWYDYYTGADINSTGEWKTLPAPLEHINLHIRGGSILPWQKHALNTHLSRMNPLGLLIALDENKEARGELFWDDGKSKDTVTKNTYIFSEFSVTQNHLNVTISSASYKDPNNLEFQEVKIFGTEEIFNVRVKQNGVLSQMSPQVTYNSTLKVATITDLHLVLGEPYAIHWSTKRDQEKIDCYPDEHGASEANCTARGCIWEESDTPGVPYCFFASDLYSVSNVQYHQNEATADISLKDSPYSNAFPSTPVKQLQVQVIYHKNEMLQFKIYDPNDSRYEVPVPLNIPISPSSTTDGRLYDVLIKENPFGIEIRRKSTGTVIWDSQLLGFTFNDMFIRISTRLPSTHIYGFGETEHTSFKIDLNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLLNSNAMDVTFQPLPALTYRTTGGILDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDTEIASLYDEMVAKQIPYDVQYSDIDYMERQLDFTLSPKFSGLPDLINRMKRDGMRVILILDPAISGNETEPYPAFTRGLQEDVFIRYPNGGDIVWGKVWPDYPGIVVNSSLDWDSQVELYRAYVAFPDFFRNSTVTWWKKEIEELHTNQQNPTKSLKFDGLWIDMNEPSSFVNGAVPPGCSDATLNRPPYMPHLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHSLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGQWAGHWLGDNTAAWDQLGKSIIGMMEFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDEAFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDKETWNIDKQFLLGPAFLISPVLEPNARNVSAYFPTALWYDYYTGVAINSTGEWKTLAAPLEHINLHVRGGYILPWQRPALNTHLSRMNPLGLLIALDENKEARGELFWDDGKSKDLTTNNILCKFSVTQNHLDVSAVGSTFSNPDDLAFQEIKIFGTQVLHNVTVKHNGVTSQMSPQVTYDPNMKVAVITGIQLLLNESYTVEWEDSIKDEEKMDCYPDQTGASEASCAARGCIWKESNTPGVPYCYFVNDLYSVSNVQHLEKEATANISLKNSPYSNAFPSTPVKQLQLSVVYHKNEMLQFKIYDPNHSRYEVPVPLNIPSSPSSTTDGRLYDVLIKENPFGIEIRRKSTGTVIWDSQLLGFTFNDMFIRISTRLPSTHIYGFGETEHTSFKIDLNWHTWGMFSRDEPPGYKKNSYGVHPYYMGLEEDGNAHGVLLLNSNAMDVTFQPTPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDTEIASLYDEMVAKQIPYDVQYSDIDYMERQLDFTLSPKFSGLPDLINRMKRDGMRVILILDPAISGNETEPYPAFTRGLQEDVFIRYPNGGDIVWGKVWPDYPGIVVNSSLDWDSQVEQYRAYVAFPDFFRNSTVTWWKKEIEELHTNPQNPTKSLKFDGLWIDMNEPSSFVNGAVPPGCSDATLNRPPYMPHLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHSLYGWSQTRPTYVAVQEVTGERGIVITRSTFPSSGRWAGHWLGDNTAAWNQLGKSIIGMMEFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDEAFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVADRETWNIDRQFLLGPAFLISPVLEPNARTVDAYFPRARWYDYYTGADINARGQWKTLPAPLEHINLHVRGGYILPWQEPAMNTHLSRRKLMGLKVALDDEGNAEGWLFWDDGQSINITSRYYLARFSVSENTLWRHEIFNNYITGTSPVYLGYIEIWGLGTVSPNSVKIFWNSKNEIVPADYNTQSQVLKVNVTTKGIGLHRFEAMTWNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3Y9</accession>
    <name>A0A9J7K3Y9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hairy and enhancer of split-related protein HELT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HES/HEY-like transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Helt</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Self-associates. Interacts with HES5 and HEY2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HEY family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035308247.1">
        <property type="nucleotide sequence ID" value="XM_035452356.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317702.1">
        <property type="nucleotide sequence ID" value="XM_035461811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3Y9"/>
    <dbReference type="GeneID" id="100751200"/>
    <dbReference type="KEGG" id="cge:100751200"/>
    <dbReference type="CTD" id="391723"/>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11408">
        <property type="entry name" value="bHLH-O_HELT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000054">
        <property type="entry name" value="hairy and enhancer of split-related protein HELT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="12">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035308247.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27013" checksum="0FFA4CDF5B6B6EDE" modified="2023-06-28" version="1">MSDRLKERKRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQSSGKLEKAEILEMTVQYLRALHSADFPRGREKAELLAEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKARLGAEPAFPPLSLPESDFSYQLHPAGPEFAGHSPGEATVFPQGATPGSLPWPHGAARSPALSYLSSAPVPLPSPAQQHSPFLAQMQGLDRHYLNLIGHAHSNTLNLHTPQHPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4H1</accession>
    <name>A0A9J7K4H1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">X-linked retinitis pigmentosa GTPase regulator-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rpgrip1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035308980.1">
        <property type="nucleotide sequence ID" value="XM_035453089.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315249.1">
        <property type="nucleotide sequence ID" value="XM_035459358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K4H1"/>
    <dbReference type="GeneID" id="100757527"/>
    <dbReference type="KEGG" id="cge:100757527"/>
    <dbReference type="CTD" id="57096"/>
    <dbReference type="OrthoDB" id="2133912at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046548">
        <property type="term" value="P:retinal rod cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000073">
        <property type="entry name" value="protein fantom isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000189">
        <property type="entry name" value="X-linked retinitis pigmentosa GTPase regulator-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041091">
        <property type="entry name" value="RPGRIP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF3">
        <property type="entry name" value="X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18111">
        <property type="entry name" value="RPGR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="736"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="882"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="953"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="260"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035308980.1"/>
        </source>
    </evidence>
    <sequence length="1257" mass="142629" checksum="96EE9C7CAB14834B" modified="2023-06-28" version="1">MTNIVSSRISYSPITEVITHLLDHIPEDLPVRDTDDSIHLLEGTSGKSVKAQSQVGRMSQKQLNYRLFHLHEKPVLVKELPPKQRDKSKRQRSTVQQSTSTQPDLRAPAGIREPARQPRCSSAPLRLLVPRKKAHLQRRCPSSAAGGAQPRVHAGRRLSHTPGPKDRHSYTSPPTFKGYSADECNRMDITSEPSQLAPIMITTQVDEPPGSPERRPRDAKLAQTSPVECARKAAELRASIKENVELIRLKKLLYEKNASLAATEARLTQVQEAYEDLLQKNQGILNATHDAFLSQVNELKKELTEESKKVMSLKTQLEDVSILQITLKEFQVRVEDLENERKLLSDSYDKLLENMPDSSHQPPWSSEQAKEQIPMPACPLQSQLDTGMEETEVLLQATNEIAEGEDLRHEVTKNCYQHEWEEEELQTAATEPQSPEEPSEPAAQPTLFQQIEQIEPSEPEAPEENNLSQMLNELQVSHAETTLELEKTRDMLFLQRKINVCYQEEMEAMMTKADNENRDHKEKLEMLNHLLDLKNSRIKLLEEQLRDIAYGTRQPSLCLESLPAHRGEDEVDISLLHRNENLFELHIHQAFLTPAALVQAGDTQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQFVVQTDSLFLHYLQGTSVRLDLHQAVANEHHILATGRISFDKVLETVEKVHGLAALTGAGGEDLGVLEYWMRLCLPLKASLQACNKQKKAQAYLSANVLGAWKAQKDESRSESWTPRNELRIEITGCCGLRSPWLGTQPSPYAMYRFFTFPEHDTVVIPASNNPYFKDQALFPVFVTSDLDQYLRQEALSIYVFDDEDTELGSYLGRAHVPLLPLAQNKSIKGDFNLTDSSEKSSGSIKVQLDWEYDYMSPEVPNPEAKTENEEEEEEDEEDEEEEEEEEEDTKDDLEASTTEEMAPYLPQDQMASIEIPIEAGQCHMRRKPPPTAERKEREHQVASYSRRKHSKKTGGQDKNRMEYLSRNILNGNTLQVHYTELKFSGLKMSQDDGFKIQDKKAKTPPSQPSPKQEDPSHPTKAQESSGQTSEASEVQTTDSDDIIVTPQAQACPKADSEKICIEIVSLAFCPDADVMFDENIQQVYVEYKFCDLPLSETETPVSLRKPRAGEEIHFHFSKVIDLDPVEQQGRRQFLFAMLHAQDPEEGRLKFTVVSEPLDEEKKECQDVGYAFLELWQILESGRDILEQELEIVSPGDRAIQIGRLKVSLRAAAALHSIYKEMTEDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KAE4</accession>
    <name>A0A9J7KAE4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal biogenesis factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC100764299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035292393.1">
        <property type="nucleotide sequence ID" value="XM_035436502.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302193.1">
        <property type="nucleotide sequence ID" value="XM_035446302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KAE4"/>
    <dbReference type="GeneID" id="100764299"/>
    <dbReference type="KEGG" id="cge:100764299"/>
    <dbReference type="OrthoDB" id="8828063at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RBIS"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL BIOGENESIS FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35544:SF4">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15679">
        <property type="entry name" value="DUF4665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035302193.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11116" checksum="23F49EC9325144B7" modified="2023-06-28" version="1">MAKNKFKGQKSSNVFHIASQKTFKVKNKAKPVTTNLKKINIMNDEKVNRMNTAFINIQKELANFSKSLSIKSMQKELQHHENEPANVDEATRLMAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KE64</accession>
    <name>A0A9J7KE64_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Strit1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035302664.1">
        <property type="nucleotide sequence ID" value="XM_035446773.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306956.1">
        <property type="nucleotide sequence ID" value="XM_035451065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KE64"/>
    <dbReference type="GeneID" id="113832890"/>
    <dbReference type="KEGG" id="cge:113832890"/>
    <dbReference type="CTD" id="100507537"/>
    <dbReference type="OrthoDB" id="9030109at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031449">
        <property type="term" value="P:regulation of slow-twitch skeletal muscle fiber contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20247">
        <property type="entry name" value="DWORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044529">
        <property type="entry name" value="DWORF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22030">
        <property type="entry name" value="DWORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035306956.1"/>
        </source>
    </evidence>
    <sequence length="35" mass="3793" checksum="6873CC37CD99E2A8" modified="2023-06-28" version="1">MAEKADSTSPQLMVPVLLLVGWIVGCIIVVYIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KFZ3</accession>
    <name>A0A9J7KFZ3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase RNF216-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100765983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309663.1">
        <property type="nucleotide sequence ID" value="XM_035453772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KFZ3"/>
    <dbReference type="GeneID" id="100765983"/>
    <dbReference type="KEGG" id="cge:100765983"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000016">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF216 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="329"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035309663.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="82320" checksum="320A5AD5A6DC6536" modified="2023-06-28" version="1">MENIFKARSSDWSFREGCHLVRWESLLTARGEILDTCTTNYDQLGIPGPASPLGAHPLEELEDQRLAVIEDTSPAVPLPRSMEEKLENMRGKEAAEIDEEFVTLLVKETEARFPDVAKGYVKEVIHLRDYYDLNVLCNFLLENPDYPKREERVIMYPSSSLLPSQDDVKLPKVDFFDYFKLTPLNQQCFIQAADLLMAEFQMLSSEDINWALQELKGHYAITRKALSDAVKLWQERSTEASGKQKKRKEMHEDSFIDFKFQQGNIKIEKRMFLLENKRQHGRSYDQKDLHPAVQQEQEFYEQKMKEMAEREDFLLALQMNREEYQKEGQLIECGCCYGEFPFEELTQCSDAHLFCKECLIRYAQETVFGSGKSELTCMEGNCTCSFPTSELEKVLPQTILCKYHERRAEEDITAACADELLRCPSCNFPALLDREVKTFSCPNPGCQKETCRKCQGLWKEHTGLTCEELAEKDEIKYRASVEEKMTAALIRKCHQCGAGLLKSEGCNHMTCRCGAHMCYLCRVSINGYDHFCQHPRFLGASCQECSRCSLWTDPTEDDEKLIEEIQKQAAEEQKRKNGETTFKRIGPPLEKPASKVQHVEGQPWPVPENPFPQIPPYFFVLPNFLLPHGWPMFNNLPINAHPRPAAYIPPLPNYGFGNMHVPLDGGDGDDDGSGNDGDGDHDRRDDDEEEEDGDGGYRGDGDDGDGGYRGDGDDGDGGYRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3GS17</accession>
    <name>G3GS17_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Slc6a6</name>
        <name evidence="21" type="ORF">I79_000324</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70687"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:70688"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71247"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hypotaurine(out) + chloride(out) + 2 Na(+)(out) = hypotaurine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71243"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71244"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>taurine(out) + chloride(out) + 2 Na(+)(out) = taurine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71223"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71224"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000005">
        <property type="protein sequence ID" value="EGV97716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007610973.1">
        <property type="nucleotide sequence ID" value="XM_007612783.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284687.1">
        <property type="nucleotide sequence ID" value="XM_027428886.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GS17"/>
    <dbReference type="STRING" id="10029.G3GS17"/>
    <dbReference type="PaxDb" id="10029-XP_007636064.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023862.1">
        <property type="protein sequence ID" value="ENSCGRP00001019618.1"/>
        <property type="gene ID" value="ENSCGRG00001019005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765478"/>
    <dbReference type="KEGG" id="cge:100765478"/>
    <dbReference type="CTD" id="6533"/>
    <dbReference type="eggNOG" id="KOG3660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154583"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022858">
        <property type="term" value="F:alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005369">
        <property type="term" value="F:taurine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002434">
        <property type="entry name" value="Na/ntran_symport_taurine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF141">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01200">
        <property type="entry name" value="TAUTRANSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 18" id="KW-0769">Symport</keyword>
    <keyword evidence="6 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="73"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="343"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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    <feature type="binding site" evidence="16">
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV97716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027284687.1"/>
        </source>
    </evidence>
    <sequence length="632" mass="71084" checksum="3D046AAF52F0FB05" modified="2011-11-16" version="1">MNPVHPENEEMATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFHSFQTELPWAHCNHSWNTPHCMEDTLRRNESLWVSLSASNFTSPVIEFWERNVLSLSSGIDEPGALKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREVFIAILCSISYLLGLSMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCAGCFIFSLVKYVPLTYNKVYVYPDWAIGLGWGLALSSMVCIPLVIAILLCRTEGPFRVRIQYLITPREPNRWAVEREGATPFHSRTSLVMNGALMKPSHVIVETMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3GUK1</accession>
    <name>G3GUK1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Fgf23</name>
        <name evidence="4" type="ORF">I79_001363</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000031">
        <property type="protein sequence ID" value="EGV98499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003496132.1">
        <property type="nucleotide sequence ID" value="XM_003496084.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284019.1">
        <property type="nucleotide sequence ID" value="XM_027428218.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GUK1"/>
    <dbReference type="STRING" id="10029.G3GUK1"/>
    <dbReference type="PaxDb" id="10029-XP_007637443.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026133.1">
        <property type="protein sequence ID" value="ENSCGRP00001021889.1"/>
        <property type="gene ID" value="ENSCGRG00001020603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763837"/>
    <dbReference type="KEGG" id="cge:100763837"/>
    <dbReference type="CTD" id="8074"/>
    <dbReference type="eggNOG" id="KOG3885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160821"/>
    <dbReference type="OMA" id="PSTHDPW"/>
    <dbReference type="OrthoDB" id="8909943at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005105">
        <property type="term" value="F:type 1 fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030502">
        <property type="term" value="P:negative regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090080">
        <property type="term" value="P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010966">
        <property type="term" value="P:regulation of phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904383">
        <property type="term" value="P:response to sodium phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042369">
        <property type="term" value="P:vitamin D catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044524210" description="Fibroblast growth factor" evidence="2">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV98499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027284019.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27909" checksum="9BB529A3E8F4244E" modified="2011-11-16" version="1">MLGTCLRLLVGVLCSACSLGTVRAYPDTSPLLGSNWGSLTHLYTATARNSYHLQIHKDGRVDGTPHQTIYSALMIRSEDAGFVIITGAVTRRFLCMDLRGNIFGSHHFSPENCRFRQRTLENGYDVYLSPQHHYLVSLGRAKRPFEPGTNPPPFSQFLARRNEVPLLRFHTARPRRHTRSAEDPPEWDPLNVLKPRPRATPVPVSCSRELPSAEEGDLAASDPLGVLRRGRGDARGGAGGVDRCRPFPRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3GUY0</accession>
    <name>G3GUY0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytanoyl-CoA hydroxylase-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phytanoyl-CoA hydroxylase-associated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Phyhip</name>
        <name evidence="8" type="ORF">I79_001505</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
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        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="5">
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            <strain evidence="12">17A/GY</strain>
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    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="3">Its interaction with PHYH suggests a role in the development of the central system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with PHYH and ADGRB1.</text>
    </comment>
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        <text evidence="1">Belongs to the PHYHIP family.</text>
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        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN"/>
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        <location>
            <begin position="6"/>
            <end position="115"/>
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<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    <reference evidence="78" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="78">CHO K1 cell line</strain>
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    <reference evidence="76" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="79" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="79">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="79" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="79">17A/GY</strain>
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    <reference evidence="80 81" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="80 81">17A/GY</strain>
            <tissue evidence="80 81">Liver</tissue>
        </source>
    </reference>
    <reference evidence="77" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="catalytic activity">
        <reaction evidence="65">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
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            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
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    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O</text>
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            <dbReference type="ChEBI" id="CHEBI:13193"/>
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        <physiologicalReaction direction="left-to-right" evidence="19">
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    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O</text>
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    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O</text>
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        <physiologicalReaction direction="left-to-right" evidence="7">
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    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48812"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
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            <dbReference type="ChEBI" id="CHEBI:15379"/>
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            <dbReference type="ChEBI" id="CHEBI:90632"/>
            <dbReference type="ChEBI" id="CHEBI:90812"/>
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        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48808"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:90632"/>
            <dbReference type="ChEBI" id="CHEBI:90813"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2</text>
            <dbReference type="Rhea" id="RHEA:42596"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:82629"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:42597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="67">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:23728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="EC" id="1.14.99.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="67">
            <dbReference type="Rhea" id="RHEA:23729"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50852"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:50853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:78837"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:50857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate</text>
            <dbReference type="Rhea" id="RHEA:42284"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:82626"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:42285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="57">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate</text>
            <dbReference type="Rhea" id="RHEA:42280"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:82628"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="57">
            <dbReference type="Rhea" id="RHEA:42281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3</text>
            <dbReference type="Rhea" id="RHEA:50444"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:133133"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50445"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50848"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:90820"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48840"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:90819"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:48841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50196"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:132087"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:50197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48836"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:90818"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50200"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:132083"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:50201"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48852"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:77224"/>
            <dbReference type="ChEBI" id="CHEBI:90824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1</text>
            <dbReference type="Rhea" id="RHEA:50424"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:71589"/>
            <dbReference type="ChEBI" id="CHEBI:133084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:50425"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="66">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:75455"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:136655"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="66">
            <dbReference type="Rhea" id="RHEA:75456"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="64">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:75451"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:90850"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="64">
            <dbReference type="Rhea" id="RHEA:75452"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="63">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:75447"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:77895"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="63">
            <dbReference type="Rhea" id="RHEA:75448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="62">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:75459"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:77852"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="62">
            <dbReference type="Rhea" id="RHEA:75460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50860"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:133819"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:50861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50864"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:133820"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:50865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:54212"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
            <dbReference type="ChEBI" id="CHEBI:138100"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:54213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:53676"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
            <dbReference type="ChEBI" id="CHEBI:137582"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:53677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:53680"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
            <dbReference type="ChEBI" id="CHEBI:137583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:53681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:53684"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
            <dbReference type="ChEBI" id="CHEBI:137584"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:53685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:54204"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:76091"/>
            <dbReference type="ChEBI" id="CHEBI:138098"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2</text>
            <dbReference type="Rhea" id="RHEA:45288"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:85165"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:45289"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:54216"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:138100"/>
            <dbReference type="ChEBI" id="CHEBI:138101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:54217"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:54208"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:138098"/>
            <dbReference type="ChEBI" id="CHEBI:138099"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:45292"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:85165"/>
            <dbReference type="ChEBI" id="CHEBI:85166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:45293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="69">
            <text>prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50432"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:90793"/>
            <dbReference type="ChEBI" id="CHEBI:133084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="69">
            <dbReference type="Rhea" id="RHEA:50433"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="68">
            <text>prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42600"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:82629"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="68">
            <dbReference type="Rhea" id="RHEA:42601"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="70">
            <text>prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50448"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:133133"/>
            <dbReference type="ChEBI" id="CHEBI:133134"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="70">
            <dbReference type="Rhea" id="RHEA:50449"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="29">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="34">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="36">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="32">Endoplasmic reticulum membrane</location>
            <topology evidence="32">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="30">Microsome membrane</location>
            <topology evidence="30">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Nucleus inner membrane</location>
            <topology evidence="31">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="33">Nucleus outer membrane</location>
            <topology evidence="33">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="35">Belongs to the prostaglandin G/H synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="73">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.1" evidence="37"/>
    <dbReference type="EMBL" id="JH000055">
        <property type="protein sequence ID" value="EGV99554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003496822.1">
        <property type="nucleotide sequence ID" value="XM_003496774.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016836358.1">
        <property type="nucleotide sequence ID" value="XM_016980869.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273214.1">
        <property type="nucleotide sequence ID" value="XM_027417413.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035301145.1">
        <property type="nucleotide sequence ID" value="XM_035445254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GWV6"/>
    <dbReference type="STRING" id="10029.G3GWV6"/>
    <dbReference type="PaxDb" id="10029-XP_007622512.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020926.1">
        <property type="protein sequence ID" value="ENSCGRP00001016682.1"/>
        <property type="gene ID" value="ENSCGRG00001016942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751220"/>
    <dbReference type="KEGG" id="cge:100751220"/>
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    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010743"/>
    <dbReference type="OMA" id="MIYPPHI"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="UniPathway" id="UPA00662"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nuclear outer membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:enzyme binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004666">
        <property type="term" value="F:prostaglandin-endoperoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050873">
        <property type="term" value="P:brown fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071498">
        <property type="term" value="P:cellular response to fluid shear stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071471">
        <property type="term" value="P:cellular response to non-ionic osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019371">
        <property type="term" value="P:cyclooxygenase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046697">
        <property type="term" value="P:decidualization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902219">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090336">
        <property type="term" value="P:positive regulation of brown fat cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031622">
        <property type="term" value="P:positive regulation of fever generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031394">
        <property type="term" value="P:positive regulation of prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032310">
        <property type="term" value="P:prostaglandin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150077">
        <property type="term" value="P:regulation of neuroinflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009624">
        <property type="term" value="P:response to nematode"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010269">
        <property type="term" value="P:response to selenium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09816">
        <property type="entry name" value="prostaglandin_endoperoxide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000002">
        <property type="entry name" value="Prostaglandin G/H synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000235">
        <property type="entry name" value="Prostaglandin G/H synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF8">
        <property type="entry name" value="PROSTAGLANDIN G_H SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="49" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="54" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="73" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="46" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="55" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="47" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="56" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="43 72" id="KW-0349">Heme</keyword>
    <keyword evidence="51 72" id="KW-0408">Iron</keyword>
    <keyword evidence="40" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="52" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="53" id="KW-0472">Membrane</keyword>
    <keyword evidence="44 72" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="48" id="KW-0492">Microsome</keyword>
    <keyword evidence="50" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="41" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="42" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="39" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="79" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="45 74" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="74">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732053" description="Prostaglandin G/H synthase 2" evidence="74">
        <location>
            <begin position="18"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="75">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="71">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="For cyclooxygenase activity" evidence="71">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="72">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="72">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000021"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000197"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00000224"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00000425"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00000429"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00000472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00000608"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00000678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00000763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00000931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00000949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00000973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00000990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00001068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00001077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00001305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00001414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00001567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00001578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00001580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00001587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00001704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00001736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00004509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00008928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00012440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00020406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="49">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="50">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="51">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="52">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="53">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="54">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="55">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="56">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="57">
        <source>
            <dbReference type="ARBA" id="ARBA00023566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="58">
        <source>
            <dbReference type="ARBA" id="ARBA00030839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="59">
        <source>
            <dbReference type="ARBA" id="ARBA00031216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="60">
        <source>
            <dbReference type="ARBA" id="ARBA00031793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="61">
        <source>
            <dbReference type="ARBA" id="ARBA00033144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="62">
        <source>
            <dbReference type="ARBA" id="ARBA00035976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="63">
        <source>
            <dbReference type="ARBA" id="ARBA00036313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="64">
        <source>
            <dbReference type="ARBA" id="ARBA00036358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="65">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="66">
        <source>
            <dbReference type="ARBA" id="ARBA00036409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="67">
        <source>
            <dbReference type="ARBA" id="ARBA00047673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="68">
        <source>
            <dbReference type="ARBA" id="ARBA00048310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="69">
        <source>
            <dbReference type="ARBA" id="ARBA00048476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="70">
        <source>
            <dbReference type="ARBA" id="ARBA00049278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="71">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="72">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="73">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="74">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="75">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="76">
        <source>
            <dbReference type="EMBL" id="EGV99554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="77">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="78">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="79">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="80">
        <source>
            <dbReference type="RefSeq" id="XP_027273214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="81">
        <source>
            <dbReference type="RefSeq" id="XP_035301145.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68968" checksum="64B9CF3CC6313CF1" modified="2011-11-16" version="1">MLFRAVLLCAALALTHAANPCCSNPCQNRGECMSIGFDQYKCDCTRTGFYGENCTIPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSSIMRYVLTSRSHLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDQKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTEAEMMYPPHTPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWDDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDTFQIEDQEYNFKQFLYNNSILIEHGLTQFVESFTRQIAGRVAGGRNVPVAVKAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDAMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVQGCPFTSFNVQDPQPTKAATINASASHSRLDDINPTVLIKGRSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3H5I1</accession>
    <name>G3H5I1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanylate cyclase soluble subunit alpha-1</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Guanylate cyclase soluble subunit alpha-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Soluble guanylate cyclase large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Gucy1a1</name>
        <name evidence="15" type="ORF">I79_005562</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JH000160">
        <property type="protein sequence ID" value="EGV95971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307874.1">
        <property type="nucleotide sequence ID" value="XM_035451983.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309589.1">
        <property type="nucleotide sequence ID" value="XM_035453698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H5I1"/>
    <dbReference type="STRING" id="10029.G3H5I1"/>
    <dbReference type="PaxDb" id="10029-XP_007613761.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020194.1">
        <property type="protein sequence ID" value="ENSCGRP00001015950.1"/>
        <property type="gene ID" value="ENSCGRG00001016414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768699"/>
    <dbReference type="KEGG" id="cge:100768699"/>
    <dbReference type="CTD" id="2982"/>
    <dbReference type="eggNOG" id="KOG4171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158285"/>
    <dbReference type="OMA" id="NANFFGE"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038060">
        <property type="term" value="P:nitric oxide-cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010750">
        <property type="term" value="P:positive regulation of nitric oxide mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060087">
        <property type="term" value="P:relaxation of vascular associated smooth muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098925">
        <property type="term" value="P:retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000002">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF4">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="481"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV95971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035307874.1"/>
        </source>
    </evidence>
    <sequence length="691" mass="77618" checksum="69E309AFFA2FFD7E" modified="2011-11-16" version="1">MFCRKFKDLKITGECPFSLLAPGQVPKEPSEEVSGGSEGCQATLPICQDIPEKNAQGNLPQRKTSRNRVYLHTLAESICKLIFPEFERLNLALQRTLAKHKIKEDRKSSEKEDLEKIIAEQAIASGVPVEALKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAEKRGRLEDASILCLDKDHDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSDCTEFVNQPYLLYSVQVKSTKPSLSPGKPQSSLVIPVSLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFFEILTPKINQTFSGIMTMLNMQFVIRVRRWDNSVKKSSRVMDLKGQMIYIVESNAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKKTVDLLCSIFPSEVAQQLWQGQIVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSDIPGICHFLDAYHHQGPNSKPWFQQKDVEDGNANFLGKASGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3H8R9</accession>
    <name>G3H8R9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 14">Nucleoporin p58/p45</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Predicted gene, 49336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Nup58</name>
        <name evidence="10" type="ORF">I79_006780</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000218">
        <property type="protein sequence ID" value="EGW04627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003500551.1">
        <property type="nucleotide sequence ID" value="XM_003500503.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246216.1">
        <property type="nucleotide sequence ID" value="XM_027390415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H8R9"/>
    <dbReference type="SMR" id="G3H8R9"/>
    <dbReference type="STRING" id="10029.G3H8R9"/>
    <dbReference type="GlyGen" id="G3H8R9">
        <property type="glycosylation" value="4 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007609480.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019261.1">
        <property type="protein sequence ID" value="ENSCGRP00001015022.1"/>
        <property type="gene ID" value="ENSCGRG00001015740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763296"/>
    <dbReference type="KEGG" id="cge:100763296"/>
    <dbReference type="CTD" id="9818"/>
    <dbReference type="eggNOG" id="ENOG502QRD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111111"/>
    <dbReference type="OMA" id="RDNTDVF"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15967">
        <property type="entry name" value="Nucleoporin_FG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGW04627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027246216.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="59458" checksum="50E7CFA3E77C3CC6" modified="2011-11-16" version="1">MSTGFSFGSGTLGSTTVAPGGTGTGGGFSFGTGTSSTPSVGLNFGTLGSSATPASTSASASGFGSGLFGAKPPTSFTLGGASSGTPATTSASTTGFSLGFSKPAASATPFALPGTSTSASGLTLSSALTSTPAASTGFTLNNLGTTPATTTTASTGLSLGGALAGLGGSLFQSANTAASGLGQNALSLSLGTTAPASTACNEGLGGIDFSTSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAASGLQRNTLNIDKLKLETAQELKNAEIALRTQKTPPGLQHENTAPADYFRVLVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLSYRKMFLGDAVDVFEARRAEAKKWQNAPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGASSGFGSGTTGASTFGFGTTDKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKRPPAGNKRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3HBD7</accession>
    <name>G3HBD7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 12">Protein Tob1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Transducer of ErbB-2.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">Tob1</name>
        <name evidence="7" type="ORF">H671_7g18398</name>
        <name evidence="6" type="ORF">I79_007765</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
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        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the BTG family.</text>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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            <begin position="40"/>
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        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Antp homeobox family. Labial subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000291">
        <property type="protein sequence ID" value="EGW08849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502031.1">
        <property type="nucleotide sequence ID" value="XM_003501983.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285434.1">
        <property type="nucleotide sequence ID" value="XM_027429633.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HD70"/>
    <dbReference type="STRING" id="10029.G3HD70"/>
    <dbReference type="PaxDb" id="10029-XP_007620625.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022851.1">
        <property type="protein sequence ID" value="ENSCGRP00001018607.1"/>
        <property type="gene ID" value="ENSCGRG00001018306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759424"/>
    <dbReference type="KEGG" id="cge:100759424"/>
    <dbReference type="CTD" id="3198"/>
    <dbReference type="eggNOG" id="KOG0489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157315"/>
    <dbReference type="OMA" id="SAQTFDW"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000113">
        <property type="entry name" value="homeobox protein Hox-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="226"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW08849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027285434.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36279" checksum="E438A02CCEA5B5D9" modified="2011-11-16" version="1">MDNARMSSFLEYPILGSGDSGTCSARAYTSDHGITTFQSCAVSANSCGGDDRFLVGRGVQISSPHHHHHHHPQPSTYQTSGSLGVSYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYSPCAPAVYSGNLSSPMVQHHHHHHHQGYAGGTVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETPSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGSDEKAEESSEKSSSSPCVPSPASSTSDTLPTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3HEY9</accession>
    <name>G3HEY9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catenin alpha-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Ctnna1</name>
        <name evidence="15" type="ORF">I79_009138</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000323">
        <property type="protein sequence ID" value="EGW06686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502585.1">
        <property type="nucleotide sequence ID" value="XM_003502537.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027256542.1">
        <property type="nucleotide sequence ID" value="XM_027400741.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HEY9"/>
    <dbReference type="STRING" id="10029.G3HEY9"/>
    <dbReference type="PaxDb" id="10029-XP_007632552.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030186.1">
        <property type="protein sequence ID" value="ENSCGRP00001025940.1"/>
        <property type="gene ID" value="ENSCGRG00001023395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754399"/>
    <dbReference type="KEGG" id="cge:100754399"/>
    <dbReference type="CTD" id="1495"/>
    <dbReference type="eggNOG" id="KOG3681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234543"/>
    <dbReference type="OMA" id="QENMDMF"/>
    <dbReference type="OrthoDB" id="6376697at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005915">
        <property type="term" value="C:zonula adherens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045295">
        <property type="term" value="F:gamma-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017166">
        <property type="term" value="F:vinculin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043297">
        <property type="term" value="P:apical junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071681">
        <property type="term" value="P:cellular response to indole-3-methanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090136">
        <property type="term" value="P:epithelial cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000146">
        <property type="term" value="P:negative regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001045">
        <property type="term" value="P:negative regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007406">
        <property type="term" value="P:negative regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001241">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000006">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000007">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000008">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000011">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000012">
        <property type="entry name" value="Catenin alpha-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF24">
        <property type="entry name" value="CATENIN ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00663">
        <property type="entry name" value="VINCULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="864"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGW06686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027256542.1"/>
        </source>
    </evidence>
    <sequence length="906" mass="100104" checksum="C9E2C96AE79D678F" modified="2011-11-16" version="1">MTAVHTGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKSAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGAGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVSPVQALSEFKAMDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G3HL40</accession>
    <name>G3HL40_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">LOC100752918</name>
        <name evidence="15" type="ORF">I79_011425</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000477">
        <property type="protein sequence ID" value="EGV93999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504404.1">
        <property type="nucleotide sequence ID" value="XM_003504356.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245520.1">
        <property type="nucleotide sequence ID" value="XM_027389719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HL40"/>
    <dbReference type="STRING" id="10029.G3HL40"/>
    <dbReference type="PaxDb" id="10029-XP_007624985.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013814.1">
        <property type="protein sequence ID" value="ENSCGRP00001009597.1"/>
        <property type="gene ID" value="ENSCGRG00001011683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752918"/>
    <dbReference type="KEGG" id="cge:100752918"/>
    <dbReference type="eggNOG" id="ENOG502QXYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282520"/>
    <dbReference type="OMA" id="TMPCGFL"/>
    <dbReference type="OrthoDB" id="9450875at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000010">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="42"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV93999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027245520.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34061" checksum="9321BA3128674F1F" modified="2011-11-16" version="1">MDSPSNSSIPCGFLLQGFFEFPQLRPLLFLVLLAVHLATLSGNLLILVAVVSVPSRPPMLLFLCQLSAIELCYTLVVVPRSLADLSMPGHGRGSPISFVGCAVQMQMFVALGGAECFLLAAMAYDRYVAICHPLRYASIVTPGLCARLALACCLGGLAVSVGLTVAVFHLPFCGSRLLVHFFCDITALLHLACTRSYVDELPLLGACLVLLLLPSMLILTSYGAIASALRRLHGGGGRRKAASTCASHLAVTFLHYGCATFMYVRPKSSYSPRLDRTLALVYTNVTPLLYPLIYSLRNREITSAIHRVLGLRGSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3HNM8</accession>
    <name>G3HNM8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100767000</name>
        <name evidence="15" type="synonym">LOC100767285</name>
        <name evidence="14" type="ORF">I79_012367</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000546">
        <property type="protein sequence ID" value="EGV99210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505233.1">
        <property type="nucleotide sequence ID" value="XM_003505185.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276971.1">
        <property type="nucleotide sequence ID" value="XM_027421170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HNM8"/>
    <dbReference type="STRING" id="10029.G3HNM8"/>
    <dbReference type="PaxDb" id="10029-XP_007627941.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006556.1">
        <property type="protein sequence ID" value="ENSCGRP00001004378.1"/>
        <property type="gene ID" value="ENSCGRG00001005564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767000"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282552"/>
    <dbReference type="OMA" id="AMTKIVC"/>
    <dbReference type="OrthoDB" id="9891208at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15415">
        <property type="entry name" value="7tmA_OR5J-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV99210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027276971.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34956" checksum="C5A2CCF064BE8013" modified="2011-11-16" version="1">MADVNCTFVTEFILLGLTDRGDLKVFLFILFLFIYVISLVGNLGMFFLIHITPKLHTPMYHFLRSLSFVDACYSSVFAPTLLMNFFVERETISFSACILQYFLFASLLTTEGFLLAAMAYDRYVAIVNPLTYTVAMTKLICVLLVLCSCIGGTITSLTHTIGLMKLSFCGPNVISHFFCDLPPLLKLACSDTSMNELLLLVFSGVIAMTTLLTVVISYLFIVAAILRIRSAAGRHKAFSTCASHLTAVTLFYGSISFSYIQPSSQYSLEQEKVVSVFYTLVIPMLNPLIYSLRNKEVKDAVKRVMEMKHFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3HPK4</accession>
    <name>G3HPK4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">SOSS complex subunit C</fullName>
            <shortName evidence="6">SOSS-C</shortName>
            <shortName evidence="6">SSB-interacting protein 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 6">Sensor of single-strand DNA complex subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5 6">Sensor of ssDNA subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 6">Single-stranded DNA-binding protein-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">Inip</name>
        <name evidence="8" type="ORF">H671_2g6509</name>
        <name evidence="7" type="ORF">I79_012718</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
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            <strain evidence="10">CHO K1 cell line</strain>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="6">Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).</text>
    </comment>
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        <subcellularLocation>
            <location evidence="6">Nucleus</location>
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        <text evidence="1 6">Belongs to the SOSS-C family.</text>
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        <property type="protein sequence ID" value="EGW00669.1"/>
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    </evidence>
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            <taxon>Mammalia</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">CHO K1 cell line</strain>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
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    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">17A/GY</strain>
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    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
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    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MHC class II family.</text>
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        <property type="protein sequence ID" value="EGW09105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cge:100760794"/>
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    <dbReference type="OMA" id="ADWAHQH"/>
    <dbReference type="OrthoDB" id="8935021at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:late endosome membrane"/>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:MHC class II protein complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:MHC class II protein complex binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:peptide antigen assembly with MHC class II protein complex"/>
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    </dbReference>
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        <property type="term" value="P:regulation of immune system process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
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    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001003">
        <property type="entry name" value="MHC_II_a_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF50">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00993">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00920">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0491">MHC II</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732228" evidence="13">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="129"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGW09105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027244525.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28928" checksum="3DB55F1B33C2F3B8" modified="2011-11-16" version="1">MDQEQKPGAGLLHLLQLLCLLPRCWAVPGGAPAPVLWEGLQNHTFRHTVFCQDGNPSIGLSESYDEDQLFYDFSQNTRVPRLPDFADWAQEQGDASAISFDKEFCNMLIQEIGPQLEGLIPVSRGLPVPEVFTLKPLEFGKPNTLVCFISNLFPPTLTVSWQHHFVPVEGASPTYISAIDGLTFQAFSYLNFTPEPFDIYSCVVTHEIDSYTPIAHWVPQNALPSDLLENVLCGLAFGLGLLGIITGIAFFIWSQKPCSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3HRX6</accession>
    <name>G3HRX6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">Mitochondrial glutathione transporter SLC25A40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 16">Solute carrier family 25 member 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 23 24" type="primary">Slc25a40</name>
        <name evidence="18" type="ORF">H671_1g2510</name>
        <name evidence="17" type="ORF">I79_013601</name>
    </gene>
    <organism evidence="17 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23 24">17A/GY</strain>
            <tissue evidence="23 24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glutathione(in) = glutathione(out)</text>
            <dbReference type="Rhea" id="RHEA:74819"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Mitochondrion inner membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000645">
        <property type="protein sequence ID" value="EGW07204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE664964">
        <property type="protein sequence ID" value="ERE89212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016832977.1">
        <property type="nucleotide sequence ID" value="XM_016977488.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247348.1">
        <property type="nucleotide sequence ID" value="XM_027391547.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306653.1">
        <property type="nucleotide sequence ID" value="XM_035450762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HRX6"/>
    <dbReference type="STRING" id="10029.G3HRX6"/>
    <dbReference type="PaxDb" id="10029-XP_007613218.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000203.1">
        <property type="protein sequence ID" value="ENSCGRP00001000179.1"/>
        <property type="gene ID" value="ENSCGRG00001000177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750700"/>
    <dbReference type="KEGG" id="cge:100750700"/>
    <dbReference type="CTD" id="55972"/>
    <dbReference type="eggNOG" id="KOG0761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160249"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034634">
        <property type="term" value="F:glutathione transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000141">
        <property type="entry name" value="Mitochondrial carrier protein MTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF5">
        <property type="entry name" value="MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A40-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="140"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="234"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW07204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ERE89212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027247348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035306653.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39987" checksum="33130D49B5066316" modified="2011-11-16" version="1">MEPETEGPPPIIHVTPLQQMLASCTGAILTSLMMTPLDVVKIRLQAQKNPFPKGKCFVYSNGLMDHMCVCEDGNNKAWYKKPGNFQGTLDAFLKILRNEGIKSLWSGLPPTLVMAVPATVIYFTCYEQLSAFLRAKLGENETRIPIVAGIVARFGAVTVISPLELIRTKVQSKKFSYKELHRFVSMKVSEDGWISLWKGWAPTILRDVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQLWTHESRKSPVPFHLSTWAIMKNIVSESGFSGLFTGLIPRLIKIAPACAIMISTYEFGKAFFQKQNVERQYNSLDGLLTRNVNQSQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3I852</accession>
    <name>G3I852_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Ubap1</name>
        <name evidence="14" type="ORF">I79_019710</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with PTPN23. Interacts (via UBA domains) with ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH001484">
        <property type="protein sequence ID" value="EGW04509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511279.1">
        <property type="nucleotide sequence ID" value="XM_003511231.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259140.1">
        <property type="nucleotide sequence ID" value="XM_027403339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I852"/>
    <dbReference type="STRING" id="10029.G3I852"/>
    <dbReference type="PaxDb" id="10029-XP_007625557.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013553.1">
        <property type="protein sequence ID" value="ENSCGRP00001009350.1"/>
        <property type="gene ID" value="ENSCGRG00001011485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769433"/>
    <dbReference type="KEGG" id="cge:100769433"/>
    <dbReference type="CTD" id="51271"/>
    <dbReference type="eggNOG" id="ENOG502QTJC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008092"/>
    <dbReference type="OMA" id="ENWKPWP"/>
    <dbReference type="OrthoDB" id="2018023at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14315">
        <property type="entry name" value="UBA1_UBAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14316">
        <property type="entry name" value="UBA2_UBAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1920:FF:000001">
        <property type="entry name" value="Ubiquitin associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1920">
        <property type="entry name" value="UBAP1 SOUBA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049467">
        <property type="entry name" value="UBAP-1-like_UBA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038870">
        <property type="entry name" value="UBAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042575">
        <property type="entry name" value="UBAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023340">
        <property type="entry name" value="UMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960:SF2">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22567">
        <property type="entry name" value="UBA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21267">
        <property type="entry name" value="UBAP-1_UBA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51497">
        <property type="entry name" value="UMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UMA" evidence="13">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="12">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="12">
        <location>
            <begin position="448"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW04509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027259140.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="54805" checksum="01BBFD8DA2D1153A" modified="2011-11-16" version="1">MASKKLGSDFHGTFSYLDDVPFKIGDKFKTPAKVGLPIGFSMPDCLQVIREVQYDFSLEKKTIEWAEDVKLIQEAQREAERKAEDAEAKVNSKSGPEGDSKMSFSKTHNTATMPPPINPILASLQHNSILTPTRVSSSATKQKVLSPPHTKADFNPADFECEEDPFDNLELKTIDEKEELRNILVGTTGPIMAQLLDSNSPRGSPGSVLQDEEVLASLEQATLDFKPLHKPNGFITLPQLGNCEKMSLSSKVSLPPIPTVSNIKSLSFPKLDSDDSNQKTVKLASTFHSTSCLRSGTSRNFLKPSTQSSASELNGDHALGLSALNLNSGTEVPTMTSSQMPSLSVLSVCTEESSPPNTCPTVTPLNFSVSQVPSCPQAYLELQALSPSERQCVETVVNMGYSYDCVLRAMKKKGENIEQILDYLFAHGQLCEKGFDPLLVEEALEMHQCSEEKMMEFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLMARAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3IG67</accession>
    <name>G3IG67_CRIGR</name>
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        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
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        <name evidence="15 18" type="primary">LOC100759483</name>
        <name evidence="14" type="ORF">I79_022748</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002516">
        <property type="protein sequence ID" value="EGW14317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027421136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IG67"/>
    <dbReference type="STRING" id="10029.G3IG67"/>
    <dbReference type="PaxDb" id="10029-XP_007624431.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002673.1">
        <property type="protein sequence ID" value="ENSCGRP00001002114.1"/>
        <property type="gene ID" value="ENSCGRG00001002181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759483"/>
    <dbReference type="KEGG" id="cge:100759483"/>
    <dbReference type="eggNOG" id="ENOG502SJBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282514"/>
    <dbReference type="OMA" id="NQWLLFF"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="7tmA_OR5D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="42"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW14317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027276937.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35093" checksum="EF9A59B0F6EDD6EF" modified="2011-11-16" version="1">MSLIDGNNSGAIFTLLGFSDYPELKVPLFLVFLTIYSITVVGNIGMILIIRINTKLHTPMYFFLSHLSFVDFCYSSIVAPKMLVNLVIIDRTISFLGCLVQFFFFCTFVVTESFLLGVMAYDRFVAICNPLLYTVAMSQRLCAMLVLGSYAWGVVCSLILTCSALNLSFRGFNMINHFFCEFSSLLSLSCSDTFVSQLLLFIFATFNEISTLLIILLSYVLIVVTILKMNSASGRRKAFSTCASHLTAITIFHGTILFLYCVPNSKNSRHTVKVASVFYTVVIPMLNPLIYSLRNKDVKDTVRKIIDTKVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3II07</accession>
    <name>G3II07_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin 80</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 11">Keratin, type II cytoskeletal 80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Krt80</name>
        <name evidence="7" type="ORF">I79_023468</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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                <person name="Samoudi M."/>
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                <person name="Goesmann A."/>
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                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
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                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
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                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
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                <person name="Wang J."/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
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                <consortium name="RefSeq"/>
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        </citation>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <text evidence="1 14">Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
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                <person name="Budach W.E."/>
                <person name="Galosy S."/>
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                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
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            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
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                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
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                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <strain evidence="10">17A/GY</strain>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR47465:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN EHOX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47465">
        <property type="entry name" value="MCG113260-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
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    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="73"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
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    <evidence type="ECO:0000256" key="1">
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    <accession>A0A061I033</accession>
    <name>A0A061I033_CRIGR</name>
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            <fullName evidence="12">Stress-activated protein kinase JNK</fullName>
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        <name evidence="16 19" type="primary">Mapk9</name>
        <name evidence="15" type="ORF">H671_7g18527</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="12"/>
    <dbReference type="EMBL" id="KE682161">
        <property type="protein sequence ID" value="ERE67629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283456.1">
        <property type="nucleotide sequence ID" value="XM_027427655.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I033"/>
    <dbReference type="SMR" id="A0A061I033"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008292.1">
        <property type="protein sequence ID" value="ENSCGRP00001005392.1"/>
        <property type="gene ID" value="ENSCGRG00001007000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764964"/>
    <dbReference type="CTD" id="5601"/>
    <dbReference type="GeneTree" id="ENSGT00940000158327"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004705">
        <property type="term" value="F:JUN kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090594">
        <property type="term" value="P:inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900017">
        <property type="term" value="P:positive regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010744">
        <property type="term" value="P:positive regulation of macrophage derived foam cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071803">
        <property type="term" value="P:positive regulation of podosome assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061833">
        <property type="term" value="P:protein localization to tricellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046686">
        <property type="term" value="P:response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07850">
        <property type="entry name" value="STKc_JNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="366"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        </source>
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            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005392.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027283456.1"/>
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    <sequence length="423" mass="48189" checksum="0E759B486ABCE20D" modified="2014-09-03" version="1">MSDSKSDGQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVKDQPSDAAVSSKATPSQSSSINDISSMSTEHTLASDTDSSLDASTGPLEGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I0B2</accession>
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        <recommendedName>
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        <name evidence="13" type="primary">Tmem186</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
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            <taxon>Mammalia</taxon>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">17A/GY</strain>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM186 family.</text>
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        <property type="protein sequence ID" value="ERE67322.1"/>
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    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <begin position="90"/>
            <end position="111"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="144"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014604"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ERE67322.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027279724.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE682706">
        <property type="protein sequence ID" value="ERE66268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284605.1">
        <property type="nucleotide sequence ID" value="XM_027428804.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I1X5"/>
    <dbReference type="GeneID" id="113837015"/>
    <dbReference type="KEGG" id="cge:113837015"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000118">
        <property type="entry name" value="N-acetyltransferase family 8 member 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF48">
        <property type="entry name" value="N-ACETYLTRANSFERASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="79"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ERE66268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027284605.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26150" checksum="403AFFDC61A6B07B" modified="2014-09-03" version="1">MPRLDTQQSPMAPYHIRQYQDSDNKRVLDLFTRGMEEHIPATFCHVLTLPRTILLLLGLPLAMVLVSGSWLLATVCIFSLLLVLRLLARQPWKEYVAKCLRTDMADITKSYLSVCGSGFWVAESGNQVVGIVGGLPIKDPPVGRKQLELFRLSVSSQHRGQGIAKALVRTVLQFARDQGYSDVVLETSVLQRSAEALYLSMGFWRTGQYFMSVFWRLVDIPVIQLKYSFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061I2T1</accession>
    <name>A0A061I2T1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endophilin-A2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Endophilin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">Sh3gl1</name>
        <name evidence="21" type="ORF">H671_5g15163</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Implicated in endocytosis. May recruit other proteins to membranes with high curvature.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KE680550">
        <property type="protein sequence ID" value="ERE72230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272697.1">
        <property type="nucleotide sequence ID" value="XM_027416896.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061I2T1"/>
    <dbReference type="SMR" id="A0A061I2T1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030234.1">
        <property type="protein sequence ID" value="ENSCGRP00001025988.1"/>
        <property type="gene ID" value="ENSCGRG00001023427.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767945"/>
    <dbReference type="KEGG" id="cge:100767945"/>
    <dbReference type="CTD" id="6455"/>
    <dbReference type="GeneTree" id="ENSGT00940000154737"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07592">
        <property type="entry name" value="BAR_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000053">
        <property type="entry name" value="endophilin-A1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000021">
        <property type="entry name" value="Endophilin-A2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF63">
        <property type="entry name" value="ENDOPHILIN-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="20">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="243"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ERE72230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027272697.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41444" checksum="5EC23417E99A8872" modified="2014-09-03" version="1">MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVAEVLVRTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMVRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILEELADKLKRRVREASSRPKREFKPRPREPFDLGELEQPNGGFPCAPAPKITASSSFRSGDKPARTPSRSMPPLDQPSCKALYDFEPENDGELGFREGDLITLTNQIDENWYEGMLHGQSGFFPLSYVQVLVPLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IA60</accession>
    <name>A0A061IA60_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100767217</name>
        <name evidence="14" type="ORF">H671_3g10655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE673213">
        <property type="protein sequence ID" value="ERE78022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263799.1">
        <property type="nucleotide sequence ID" value="XM_027407998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IA60"/>
    <dbReference type="GeneID" id="100767217"/>
    <dbReference type="KEGG" id="cge:100767217"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15955">
        <property type="entry name" value="7tmA_OR52A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF121">
        <property type="entry name" value="OLFACTORY RECEPTOR 52A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE78022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027263799.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35776" checksum="802DAAB77855C7CE" modified="2014-09-03" version="1">MPLTNGTCFKPSIFTLIGIPGLESVQHWIGIPFFISFVLVTTGNSLLITIIHREHSLHEPMYVFLAVLAAVDLGLTICITPKMLAIFWLQSKKIHFESCLIQMYFTHTFQCMESGILLAMAFDRYVAICDPLRHSAILTKKVLITIITLVTTRASAIIIMCPLLIKLRLTHFRTTVISHSYCEHMAVVKLATEDVRINKAYGLFVAFSVLGFDVIFIFLSYAFIFQAVFKLPQKEARFKAFNTCTAHIFVFLQFYILTFFTSFIHRFGFNVAPYVHILLSNLYLLVPPLLNPIVYGVKTKQIREGVIKMFASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HKW6</accession>
    <name>A0A3L7HKW6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Rab29</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Lipid-anchor</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003501255.1">
        <property type="nucleotide sequence ID" value="XM_003501207.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273456.1">
        <property type="nucleotide sequence ID" value="XM_027417655.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HKW6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021855.1">
        <property type="protein sequence ID" value="ENSCGRP00001017611.1"/>
        <property type="gene ID" value="ENSCGRG00001017622.1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="11">
        <source>
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    <sequence length="204" mass="23101" checksum="8BFBF584682F0A73" modified="2019-02-13" version="1">MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDSEMVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPSGDPVPCLLLANKSDLSPWAVSRDQIDRFSKENGFIGWTETSVKENRNINEAMRVLVEKMMNNSREDIISLSTQGNYINLQAKSSSGWTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HNL3</accession>
    <name>A0A3L7HNL3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Tspan3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with claudin-11/CLDN11 and integrins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027270827.1">
        <property type="nucleotide sequence ID" value="XM_027415026.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HNL3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003570.1">
        <property type="protein sequence ID" value="ENSCGRP00001002634.1"/>
        <property type="gene ID" value="ENSCGRG00001002971.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765318"/>
    <dbReference type="KEGG" id="cge:100765318"/>
    <dbReference type="CTD" id="10099"/>
    <dbReference type="OrthoDB" id="9993879at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03163">
        <property type="entry name" value="TM4SF8_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000004">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF48">
        <property type="entry name" value="TETRASPANIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027270827.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28059" checksum="88A379276163019A" modified="2019-02-13" version="1">MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLFPAVVIIAVGALLFIIGLIGCCATIRESRCGLATFVFILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETAKSCNGSLANPSDLYAEGCEALVVKKLQEILMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGGTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IGC1</accession>
    <name>A0A3L7IGC1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HCLS1-associated protein X-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HS1-associating protein X-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">Hax1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAX1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003501653.1">
        <property type="nucleotide sequence ID" value="XM_003501605.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249107.1">
        <property type="nucleotide sequence ID" value="XM_027393306.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IGC1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030532.1">
        <property type="protein sequence ID" value="ENSCGRP00001026286.1"/>
        <property type="gene ID" value="ENSCGRG00001023646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761361"/>
    <dbReference type="KEGG" id="cge:100761361"/>
    <dbReference type="CTD" id="10456"/>
    <dbReference type="OMA" id="SKFNDIW"/>
    <dbReference type="OrthoDB" id="5562606at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017248">
        <property type="entry name" value="HAX-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14938">
        <property type="entry name" value="HCLS1-ASSOCIATED PROTEIN X-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14938:SF2">
        <property type="entry name" value="HCLS1-ASSOCIATED PROTEIN X-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037634">
        <property type="entry name" value="HS1-associating_X-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by caspase-3" evidence="2">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037634-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027249107.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31700" checksum="837D73F4012AA056" modified="2019-02-13" version="1">MSFFDLFRGFFGFRGPRSHRDPFFGGMTRDDDDDDDEEEEDRGTWGRGSYRFDGSQPPEEFGFNFSPEEGMRFHDNFGFDDLVRDFNSIFSEMGAWTLPSHSPELPGHGSETPGERPREGQTLRDSMLKYPDSHQPRIFEGVMESHPRPESPKPAPDWGSQGPFHRLDDIWPVTPHSRAREDNDLDSQVSQEGLGPLLQPQPKSYFKSISVTKITKPDGVVEEHRTVVDSEGRRETTVTHQEAQDSSRSDPVSERSSALDDPFSILDLFLGRWFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IR54</accession>
    <name>A0A3L7IR54_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="4 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">LOC103158908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="4 8"/>
    <dbReference type="RefSeq" id="XP_027287452.1">
        <property type="nucleotide sequence ID" value="XM_027431651.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035294479.1">
        <property type="nucleotide sequence ID" value="XM_035438588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IR54"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008543.1">
        <property type="protein sequence ID" value="ENSCGRP00001005540.1"/>
        <property type="gene ID" value="ENSCGRG00001007298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103158908"/>
    <dbReference type="KEGG" id="cge:103158908"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.10:FF:000001">
        <property type="entry name" value="Blast:Protein N-terminal glutamine amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="25"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027287452.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24001" checksum="528212493C8BFCAB" modified="2019-02-13" version="1">MEGDGPVASVPQYQPACPARDACVYSSCYCEENIWKLCEYIKTHDQYPLEECSAVFISNEKKMVPIWKQQARPGNGPVIWDYHVILLHVPREGQSFIYDLDSILPFPCPFNIYVQDALKSDDDIHPQFRRKFRVVRADSYLKNFASDRSHMKDSSGNWREPPPAYPCIETGDSKMNLHDFISMDPEVGWGAVYTLSEFVQRFSSKNCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LA31</accession>
    <name>A0A8C2LA31_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Keratin 222</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Keratin-like protein KRT222 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Krt222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027284008.1">
        <property type="nucleotide sequence ID" value="XM_027428207.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LA31"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001817.1">
        <property type="protein sequence ID" value="ENSCGRP00001001613.1"/>
        <property type="gene ID" value="ENSCGRG00001001412.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762604"/>
    <dbReference type="KEGG" id="cge:100762604"/>
    <dbReference type="CTD" id="125113"/>
    <dbReference type="GeneTree" id="ENSGT00940000159655"/>
    <dbReference type="OrthoDB" id="8861979at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052857">
        <property type="entry name" value="IF_Keratin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47082">
        <property type="entry name" value="KERATIN-LIKE PROTEIN KRT222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47082:SF1">
        <property type="entry name" value="KERATIN-LIKE PROTEIN KRT222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027284008.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34252" checksum="E5BD09C5D1D3402E" modified="2022-01-19" version="1">MELSQLLNEIRANYEQLLTRNQIETVLSTRMQLEEDITKKMDKDEEALKAAQAELREARRQCHHLQVEIESLHAVERGLENSLQASEQHYQMQLQDLESVIDRLEKELQEVRFGIERQLQEHEMLLNTKMRLEQEIATYRRLLEQEELRYYGCIQGEKKEEKPTRSKVGFLLPSAIINEISFSTKVSQKYENDNTETMTKQAVLNGNVKESAEAHGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLQSRQDNLPDIEVRLIMRRSCSIPSIKPPPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LHB0</accession>
    <name>A0A8C2LHB0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Intersex-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Med29</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003503899.3">
        <property type="nucleotide sequence ID" value="XM_003503851.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286302.1">
        <property type="nucleotide sequence ID" value="XM_027430501.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LHB0"/>
    <dbReference type="SMR" id="A0A8C2LHB0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005275.1">
        <property type="protein sequence ID" value="ENSCGRP00001003629.1"/>
        <property type="gene ID" value="ENSCGRG00001004443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772644"/>
    <dbReference type="KEGG" id="cge:100772644"/>
    <dbReference type="CTD" id="55588"/>
    <dbReference type="GeneTree" id="ENSGT00390000007540"/>
    <dbReference type="OrthoDB" id="6366949at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021018">
        <property type="entry name" value="Mediator_Med29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11568">
        <property type="entry name" value="Med29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001003629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027286302.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="21432" checksum="F780720B0DA818E5" modified="2022-01-19" version="1">MAAPQQQQQQQASAVSSAAGVSGPGSAGGPGSQPQPQPPQLVGPAPSALLQQQQQDFDPVQRYKMLIPQLKESLQTLMKVAAQNLIQNTNIDNGQKSSDGPIQRFDKCLEEFYALCDQLELCLRLAHECLSQSCDSAKHSPTLVPTATKPDAVQPDSLPYPQYLAVIKAQITCAKDIHTALLDCANKVTGKTTAASAGPGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LMR7</accession>
    <name>A0A8C2LMR7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RUN and SH3 domain containing 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">RUN and SH3 domain-containing protein 1 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Rusc1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">17A/GY</strain>
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    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <topology evidence="1 12">Multi-pass membrane protein</topology>
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    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027281967.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35418" checksum="0587E6346299303B" modified="2022-01-19" version="1">MARRNQTVISQFLLLGLPISPEDQHLFYALFLAMYLTTILGNLIIILLIQLDSRLHTPMYFFLSNLSFADFCLSSVTMPKLLQNMQSQDPSISYAGCLTQLYFFLFFGAFENFLLVAMAYDRYVAICFPLHYTSIMSPKLCVGLVVFSWVLTTFHGMIHTLLMARLSFCDDNVIPHYFCDMSPLLKLACSDTHDNEMVIFIVGGPIIVLPFLLIIVSYARIVSSIFKVPSSQGISKAFSTCGSHLSVVSLFYGTVIGLYLCPSADNSHVKKTVVSLMYTIITPMLNPFIYSLRNRDMKGALERVVFKKQISSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LSZ1</accession>
    <name>A0A8C2LSZ1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATR interacting protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ATR-interacting protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Atrip</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003504289.1">
        <property type="nucleotide sequence ID" value="XM_003504241.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270423.1">
        <property type="nucleotide sequence ID" value="XM_027414622.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LSZ1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012883.1">
        <property type="protein sequence ID" value="ENSCGRP00001008741.1"/>
        <property type="gene ID" value="ENSCGRG00001010959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762140"/>
    <dbReference type="KEGG" id="cge:100762140"/>
    <dbReference type="CTD" id="84126"/>
    <dbReference type="GeneTree" id="ENSGT00390000012850"/>
    <dbReference type="OMA" id="CALAQHH"/>
    <dbReference type="OrthoDB" id="6428926at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070310">
        <property type="term" value="C:ATR-ATRIP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033349">
        <property type="entry name" value="ATRIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594:SF1">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027270423.1"/>
        </source>
    </evidence>
    <sequence length="789" mass="86176" checksum="36F8968C9D67D95F" modified="2022-01-19" version="1">MAGTPAPSSHRKQSGGPAPLPGLSRAFDNPPSKRARSFSETADPDPEDPFGAHAEFTADDLEELDILASQALSQCPVAPRNSLASAHKVCQLDGSSNSPMRKNKENAPVKDSFELEVLQTQYKELKEKLKAMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALNEKEKEFSKKLQSLQSELQFKDAEMNELRTKLQSSERTNKLAASSTSHASPRKGSSVAIKSEACSPHVRKSSFPTKESFSANMPLSHPCQTEAGFKLLVEPEVPDNKTHSLRDNPMKQDVQQKILADSWMQRSNTQGSILINLLLKQPLVPGSSLGLCHLLSSCSEVPIGTLLQPPGLSSTLAGISGLRTIISRDGSFSPSALREAQNLAFTGLNLVARSESSHDGDLAKGSRRVFPLCQLPGAVHLLPLVQFFIGLHCQALQDLASAKKSVAPGDSPTHTSCVSSGVETSLEDSIYHLESFSVTSLSVLQHLVCHSGAVVCLLLSGLGTDAAAREGNPVQTCADTVSASREDAHDKKQHPLLKMLLQLVAFSSTASGHFQASVLSQCLKVLVKLAENASSDFLPRFSCVLPMLPQCLSSELPLPCVLLAVELLSLLVDHDSFAQQLCFHSEGCLLLRLYMYITSRPDKVASETQWLQLEQEVVWLLAKLSVQSPSLPGIGSDCQCNVEAVRVLTVMLHRQWLTVRRAGGPRTPQQKQTMRCLRDTVLLLHSLSQKDKFFTVHCVEVLHQYDQVMPGVSMLIRALPDVADCEEAALDDLCAAETDLEDSEMDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LX46</accession>
    <name>A0A8C2LX46_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Prolow-density lipoprotein receptor-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="36 39" type="primary">Lrp1</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="38" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="39">17A/GY</strain>
            <tissue evidence="39">Liver</tissue>
        </source>
    </reference>
    <reference evidence="36" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Golgi outpost</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Membrane</location>
            <location evidence="28">Coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027247995.1">
        <property type="nucleotide sequence ID" value="XM_027392194.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A8C2LX46"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013883.1">
        <property type="protein sequence ID" value="ENSCGRP00001009664.1"/>
        <property type="gene ID" value="ENSCGRG00001011627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754427"/>
    <dbReference type="KEGG" id="cge:100754427"/>
    <dbReference type="CTD" id="4035"/>
    <dbReference type="GeneTree" id="ENSGT00940000157899"/>
    <dbReference type="OrthoDB" id="10066840at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016964">
        <property type="term" value="F:alpha-2 macroglobulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034185">
        <property type="term" value="F:apolipoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="term" value="P:reactive oxygen species metabolic process"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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    <sequence length="519" mass="57455" checksum="3C3B2E68D03E9412" modified="2022-01-19" version="1">MASLGSEAEREPLLGPGSPGSREWDTVETQEHYKSRWRSVRILYLTMFLSSVGFSIVIMSIWPYLQKIDQTADASFLGWVIASFSLGQMVASPLFGLWSNYRPRKEPLIVSIFISVVANCLYAYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTSAMANTSTCQALGFILGPVFQTCFALIGEKGVTWDTIKLQINMYTAPVLLGAFLGIVNIILILFILREHRVDDSGRQCKSVNFQEENTDEVHIPEGSIDQVAVVTTNILFFVVLFIFALFETILTPLTMDMYAWTQEQAVLYDGVILAALGVEAVVVFMGVKLLSKKIDERAILLGGLVVVWVGFFILLPWGNQFPKVQWEDLHNSSIPNTTLGEIIIDLWNSPREDHSEQPTGCPIEQAWCLYTPVIHLAQFLTAAVLVGIGYPACNVMSYTLYSKVLGPKPQGMYMGWLSASGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVLTISLMGAVYRRLIAFSVRCGRIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M039</accession>
    <name>A0A8C2M039_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox protein OTX2 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Orthodenticle homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Otx2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007644945.1">
        <property type="nucleotide sequence ID" value="XM_007646755.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027386469.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M039"/>
    <dbReference type="SMR" id="A0A8C2M039"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015569.1">
        <property type="protein sequence ID" value="ENSCGRP00001011337.1"/>
        <property type="gene ID" value="ENSCGRG00001013006.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100766419"/>
    <dbReference type="CTD" id="5015"/>
    <dbReference type="OMA" id="QTNISMM"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:diencephalon morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000142">
        <property type="entry name" value="homeobox protein OTX2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003022">
        <property type="entry name" value="Otx2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003025">
        <property type="entry name" value="Otx_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013851">
        <property type="entry name" value="Otx_TF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN OTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03529">
        <property type="entry name" value="TF_Otx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01257">
        <property type="entry name" value="OTX2HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01255">
        <property type="entry name" value="OTXHOMEOBOX"/>
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    <sequence length="297" mass="32406" checksum="DB4A3AE99DDA6F6A" modified="2022-01-19" version="1">MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M4B3</accession>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
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            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="19">17A/GY</strain>
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        </source>
    </reference>
    <reference evidence="16" key="4">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.</text>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="Ensembl" id="ENSCGRT00001017466.1">
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    </dbReference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSCGRP00001013229.1"/>
        </source>
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            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027278020.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="56976" checksum="75667C6BAA1C3865" modified="2022-01-19" version="1">MGHNNSWVSPNTSHPRNTSGAEAGANRSALGELSEAQLYRQFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIVLSTSPHCCWWIYTMFFCKVVKFLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYAMSTCTEVWSNSLGHLVYVLIYNVTTVIVPVAVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVTVFILCSVPYATLVVYQTVLNVPNTSVFLLLTAIWLPKVSLLANPVLFLTVNKSVRKCLVGTLVQLHHRYSRRNVVSTGSGVAEASLEPSMRSGSQLLEMFHIGQQQIFKPSEDEEESEAKYLGSADFQAKEELASCPEGEQEPQLAPSVPPPGTVDSISQEAPVAPVEHGLLPDKYSLQFGFGPFELPPQWLSETRNSKKRLLPPLGNTPEELIQTKVPKIGRVERKMSRNNKVSIFPKVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M5U3</accession>
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        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M933</accession>
    <name>A0A8C2M933_CRIGR</name>
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        <recommendedName>
            <fullName evidence="4">Metabotropic glutamate receptor 3</fullName>
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        <name evidence="19 22" type="primary">Grm3</name>
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    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with TAMALIN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003510495.1">
        <property type="nucleotide sequence ID" value="XM_003510447.4"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035451696.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSCGRP00001015160.1"/>
        <property type="gene ID" value="ENSCGRG00001015844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760036"/>
    <dbReference type="KEGG" id="cge:100760036"/>
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    <dbReference type="GeneTree" id="ENSGT01030000234595"/>
    <dbReference type="OMA" id="CNIQDMS"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001641">
        <property type="term" value="F:group II metabotropic glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099170">
        <property type="term" value="P:postsynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15448">
        <property type="entry name" value="7tmC_mGluR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06375">
        <property type="entry name" value="PBP1_mGluR_groupII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000029">
        <property type="entry name" value="Metabotropic glutamate receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001234">
        <property type="entry name" value="GPCR_3_mGluR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01053">
        <property type="entry name" value="MTABOTROPC3R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00979">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678774" description="Metabotropic glutamate receptor 3" evidence="17">
        <location>
            <begin position="25"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="18">
        <location>
            <begin position="576"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035307587.1"/>
        </source>
    </evidence>
    <sequence length="879" mass="99016" checksum="4A7B59BCB55F188C" modified="2022-01-19" version="1">MKMLTRLQILILALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNASFTWVASDGWGAQESIIKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNFQHIGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFMCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MAX8</accession>
    <name>A0A8C2MAX8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein FAM207A isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SLX9 ribosome biogenesis factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Slx9</name>
        <name evidence="7" type="synonym">Fam207a</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027250100.1">
        <property type="nucleotide sequence ID" value="XM_027394299.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MAX8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019928.1">
        <property type="protein sequence ID" value="ENSCGRP00001015685.1"/>
        <property type="gene ID" value="ENSCGRG00001016236.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cge:100765418"/>
    <dbReference type="GeneTree" id="ENSGT00390000015709"/>
    <dbReference type="OrthoDB" id="18703at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109">
        <property type="entry name" value="PROTEIN FAM207A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027250100.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24496" checksum="6B132C6E3F8D51C6" modified="2022-01-19" version="1">MGKVRALRARVHRAAVRPDAEAAPGPAPRAPEPVLPLASAGGAGAKDWTLVHNDIFARTQIDPSALVQRLELDQKSVVSLKRGTEPKTILPKKEKLRLRHERWLQKIEAIKLAEQKLKEARRRRATVVVGDLHPLRDALPELQELEASRQQQTRCRVTSKPRPVELSRMSSAQRQQLLEEERTRFRELLASPSYRASPLLAIGRQLAHQMQLEGGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2ME57</accession>
    <name>A0A8C2ME57_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1</fullName>
            <ecNumber evidence="5">2.4.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Core 1 O-glycan T-synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Core 1 beta1,3-galactosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 30" type="primary">C1galt1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose = a 3-O-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56200"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="Rhea" id="RHEA-COMP:13922"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:137949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:56201"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose = a 3-O-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56196"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13923"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:137950"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:56197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15621"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28257"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="EC" id="2.4.1.122"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer; disulfide-linked. Interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027245699.1">
        <property type="nucleotide sequence ID" value="XM_027389898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2ME57"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020831.1">
        <property type="protein sequence ID" value="ENSCGRP00001016587.1"/>
        <property type="gene ID" value="ENSCGRG00001016873.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761169"/>
    <dbReference type="KEGG" id="cge:100761169"/>
    <dbReference type="CTD" id="56913"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000007">
        <property type="entry name" value="Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF13">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="26">
        <location>
            <begin position="96"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00053789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00064802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027245699.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="43224" checksum="3EEDCE8730639993" modified="2022-01-19" version="1">MSEMHSREMASKSWLNFLTFLCGSAIGFFLCSQLFSILLGEQGDTQPNMLHNDPHARHLDDNEPSHLQGQVNFNADSSQHKDENTDIAENLYQKVKILCWVMTSPQNLEKKAKHVKATWAQRCNKVLFMSSEENQDFPTVGLKTKEGREQLYWKTIKAFQYVHDHYLEDADWFMKADDDTYVIVDNLRWLLSRYNPEQPIYFGRRFKPYVKQGYMSGGAGYVLSKEALRRFVDAFKTEKCTHSSSIEDLALGRCMEIINVEAGDSRDTTGKETFHPFVPEHHLIKGYLPKTFWYWNYNYYPPVEGPGCCSDIAVSFHYVDSTTMYELEYLVYHLRPYGYLYRYQPALPEDILKEINQANKNEDTKVKLGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJI4</accession>
    <name>A0A8C2MJI4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTPase IMAP family member 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">GTPase, IMAP family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Gimap4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304953.1">
        <property type="nucleotide sequence ID" value="XM_035449062.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311011.1">
        <property type="nucleotide sequence ID" value="XM_035455120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MJI4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024027.1">
        <property type="protein sequence ID" value="ENSCGRP00001019783.1"/>
        <property type="gene ID" value="ENSCGRG00001019121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="107977102"/>
    <dbReference type="KEGG" id="cge:107977102"/>
    <dbReference type="CTD" id="55303"/>
    <dbReference type="OMA" id="YLMEAPE"/>
    <dbReference type="OrthoDB" id="5985928at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF182">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="6">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="225"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035304953.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37744" checksum="673E190C1E519A62" modified="2022-01-19" version="1">MAAQYHGVGSTTRKSRTSCELGNQGQGSSQLRIVLLGKTGAGKSATGNSILGEKVFQSGICAKSITKVCEKKVSTWGGREIVVVDTPGVFDTEVSDVDTRKEIARCVALTSPGPHALLLVVPLGRYSVEDHKATQKILSMFGRKARRFMILLLTRKDDLEDADIHEYLENAPGIQELVGKFENRYCLFNNKALGAEQEDQRTQLLDLVQSTVMENGGRCFSNQMYRSAEEEIQKQTREKQERYREELERERARIREEYEEQIRDLRDQLERERRKAQMEREFTRTEALYAERQRDARREVESQNTILELILRVWEVARFIINQFMQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MM42</accession>
    <name>A0A8C2MM42_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TBC1 domain family member 22B isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TBC1 domain family, member 22B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Tbc1d22b</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007642860.1">
        <property type="nucleotide sequence ID" value="XM_007644670.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250224.1">
        <property type="nucleotide sequence ID" value="XM_027394423.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MM42"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025413.1">
        <property type="protein sequence ID" value="ENSCGRP00001021169.1"/>
        <property type="gene ID" value="ENSCGRG00001020095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751571"/>
    <dbReference type="KEGG" id="cge:100751571"/>
    <dbReference type="CTD" id="55633"/>
    <dbReference type="GeneTree" id="ENSGT00940000157472"/>
    <dbReference type="OMA" id="SCYNIFN"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000009">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF462">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="210"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027250224.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="59077" checksum="D398D1FF3C14E511" modified="2022-01-19" version="1">MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNSVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPPFQTLNSKVALATAAQVLENHSKLRVKPERSQSTSSDVPASYKVIKSSSDAQLSRNSSDTCLRNSLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKWSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHSHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MM74</accession>
    <name>A0A8C2MM74_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bone marrow proteoglycan</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Proteoglycan 2, bone marrow</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Prg2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035302842.1">
        <property type="nucleotide sequence ID" value="XM_035446951.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314050.1">
        <property type="nucleotide sequence ID" value="XM_035458159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MM74"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025444.1">
        <property type="protein sequence ID" value="ENSCGRP00001021200.1"/>
        <property type="gene ID" value="ENSCGRG00001020117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757904"/>
    <dbReference type="KEGG" id="cge:100757904"/>
    <dbReference type="CTD" id="5553"/>
    <dbReference type="GeneTree" id="ENSGT00440000039859"/>
    <dbReference type="OMA" id="WGRCKRF"/>
    <dbReference type="OrthoDB" id="6369810at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002215">
        <property type="term" value="P:defense response to nematode"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032693">
        <property type="term" value="P:negative regulation of interleukin-10 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010936">
        <property type="term" value="P:negative regulation of macrophage cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032753">
        <property type="term" value="P:positive regulation of interleukin-4 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03598">
        <property type="entry name" value="CLECT_EMBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000090">
        <property type="entry name" value="Proteoglycan 2, bone marrow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033816">
        <property type="entry name" value="EMBP_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002352">
        <property type="entry name" value="Eosinophil_major_basic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF16">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00770">
        <property type="entry name" value="EMAJORBASICP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678929" evidence="5">
        <location>
            <begin position="17"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="100"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035302842.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23930" checksum="593EEDC8A1B1CEBF" modified="2022-01-19" version="1">MKFPLLLALLVGGASALHLRSETSDFKSSPRDENLPRDVELSRPEVEECPPGEELIPLEEEEGSGDEGAVSGQDMTDEDLQCPRAEDTMSLPGNPGCKTCRFLLVRNPRPFGNAQSVCQRCYRGTLASIHSFSVNFQIYSTVRGFNQGQVWIGGRIVGWGRCKRFQWVDGSSWNFAYWAAGQPRPGGGRCVTLCTQGGHWRRSHCAQRRPFICSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MMN4</accession>
    <name>A0A8C2MMN4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Chromaffin granule amine transporter isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Solute carrier family 18 (vesicular monoamine), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Slc18a1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:73740"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:73744"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003499977.1">
        <property type="nucleotide sequence ID" value="XM_003499929.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244660.1">
        <property type="nucleotide sequence ID" value="XM_027388859.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MMN4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025042.1">
        <property type="protein sequence ID" value="ENSCGRP00001020798.1"/>
        <property type="gene ID" value="ENSCGRG00001019831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755842"/>
    <dbReference type="KEGG" id="cge:100755842"/>
    <dbReference type="CTD" id="6570"/>
    <dbReference type="GeneTree" id="ENSGT00940000159352"/>
    <dbReference type="OMA" id="FGWCVDR"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015311">
        <property type="term" value="F:monoamine:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000083">
        <property type="entry name" value="synaptic vesicular amine transporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000116">
        <property type="entry name" value="synaptic vesicular amine transporter isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF31">
        <property type="entry name" value="CHROMAFFIN GRANULE AMINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="23"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027244660.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="55815" checksum="341164B9A10DE462" modified="2022-01-19" version="1">MFQVVLGAPQRLLKEGRESRQLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFRDVNSSLHRGPSVRSQQAVTSPDFSTIFSFFDNTTTTAEAHVLFHVAWTNGTIPPPVTEAGSAPKNSCLQGIEFLEEENIRVGVLFASKALMQLLVNPFVGPLTNRIGYHIPMFAGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNHERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQLCILWPSKVSSENAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCALVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCIGFAIGPSTGGAVVQVIGFPWLMVVIGVINIIYAPLCCFLQNPPAKEEKLAILSQECPMETQMYASRKPTKEFPLGDNSDDPGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MPY2</accession>
    <name>A0A8C2MPY2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metalloproteinase inhibitor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Tissue inhibitor of metalloproteinases 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Timp2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027281320.1">
        <property type="nucleotide sequence ID" value="XM_027425519.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MPY2"/>
    <dbReference type="SMR" id="A0A8C2MPY2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025460.1">
        <property type="protein sequence ID" value="ENSCGRP00001021216.1"/>
        <property type="gene ID" value="ENSCGRG00001020133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772625"/>
    <dbReference type="KEGG" id="cge:100772625"/>
    <dbReference type="CTD" id="7077"/>
    <dbReference type="GeneTree" id="ENSGT00940000158348"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03585">
        <property type="entry name" value="NTR_TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteinase inhibitor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteinase inhibitor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
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        <property type="entry name" value="TIMP"/>
    </dbReference>
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        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030490">
        <property type="entry name" value="TIMP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF24">
        <property type="entry name" value="METALLOPROTEINASE INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00288">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="7 22" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="8 22" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="10 14" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678960" description="Metalloproteinase inhibitor 2" evidence="17">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="18">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="site" description="Involved in metalloproteinase-binding" evidence="15">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Involved in metalloproteinase-binding" evidence="15">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="159"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030102"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027281320.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24344" checksum="3197B63FBAE66197" modified="2022-01-19" version="1">MGAAARSLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPDKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKSINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP</sequence>
</entry>
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    <accession>A0A8C2MRT9</accession>
    <name>A0A8C2MRT9_CRIGR</name>
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        <submittedName>
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        <submittedName>
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    <gene>
        <name evidence="2 5" type="primary">Fam217a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
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            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
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    <reference evidence="5" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027265359.1">
        <property type="nucleotide sequence ID" value="XM_027409558.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035441164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MRT9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025518.1">
        <property type="protein sequence ID" value="ENSCGRP00001021274.1"/>
        <property type="gene ID" value="ENSCGRG00001020164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760256"/>
    <dbReference type="KEGG" id="cge:100760256"/>
    <dbReference type="CTD" id="222826"/>
    <dbReference type="OrthoDB" id="8763336at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029266">
        <property type="entry name" value="FAM217"/>
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    <dbReference type="PANTHER" id="PTHR22145:SF4">
        <property type="entry name" value="PROTEIN FAM217A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22145">
        <property type="entry name" value="SI:CH211-266K22.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15344">
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        <property type="match status" value="1"/>
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        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
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            <begin position="319"/>
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    </feature>
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            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027265359.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54756" checksum="B9215CD6DDAD64DF" modified="2022-01-19" version="1">MGRKNDENCGTNLHVSSISQENFSSWNLDSEEPLAENESLLPGKDGVAGSKTNKNHQEVTAELLVLQLIISEHAHSRTQNSNQGVFQLWSSPVNKGSTMDSRELKKSSVETGFNASSSSRLFTLNHSFTNIQGLTDTKQVSPYPGQSMPTGLCWPYADGDFLRDRNENWNFKYRNGSIEDNLTDESDLSENEKMNDSSLSYFKKMDLNLKPEAIEHVERSFTEEANGVSIYADFLPAPFNTLDLHRFAFSKCETWKAVADPPESSIERLIIRLLELERLQHMTIQKEKPRLQSTFSVFSMAERPSSSKAIALKARPPKLPDTLTLQTPNVDKSRDKRKNISCSGKPEQSNSKWNWNSSGKCKLNSRPLLKCSSTAKQSVVAHDDFKNSKNSVLNPCQELPPKPTTTQATQPLAKVVSTKCFPSRSPVPVSPIPLSFPENPKEEIKTPRTKKKLHRKSILLNRPFYVQKQNSLSPSLIARGKCSPTDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MSQ6</accession>
    <name>A0A8C2MSQ6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation channel sperm-associated protein 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Cation channel, sperm associated 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Catsper3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027263433.2">
        <property type="nucleotide sequence ID" value="XM_027407632.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265561.2">
        <property type="nucleotide sequence ID" value="XM_027409760.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MSQ6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026691.1">
        <property type="protein sequence ID" value="ENSCGRP00001022446.1"/>
        <property type="gene ID" value="ENSCGRG00001020986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762411"/>
    <dbReference type="KEGG" id="cge:100762411"/>
    <dbReference type="CTD" id="347732"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47131">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47131:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="51"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027265561.2"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MU28</accession>
    <name>A0A8C2MU28_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endoplasmic reticulum resident protein 44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Erp44</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms mixed disulfides with both ERO1A and ERO1B and cargo folding intermediates; the interactions with ERO1A and ERO1B result in their retention in the endoplasmic reticulum. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003506189.1">
        <property type="nucleotide sequence ID" value="XM_003506141.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258922.1">
        <property type="nucleotide sequence ID" value="XM_027403121.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MU28"/>
    <dbReference type="SMR" id="A0A8C2MU28"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024686.1">
        <property type="protein sequence ID" value="ENSCGRP00001020442.1"/>
        <property type="gene ID" value="ENSCGRG00001019603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750874"/>
    <dbReference type="KEGG" id="cge:100750874"/>
    <dbReference type="CTD" id="23071"/>
    <dbReference type="GeneTree" id="ENSGT00930000151031"/>
    <dbReference type="OMA" id="DWCRFSN"/>
    <dbReference type="OrthoDB" id="294696at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02996">
        <property type="entry name" value="PDI_a_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03072">
        <property type="entry name" value="PDI_b'_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03070">
        <property type="entry name" value="PDI_b_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000051">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000074">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000128">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041870">
        <property type="entry name" value="ERp44_PDI_b_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041862">
        <property type="entry name" value="ERp44_PDI_b_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679121" description="Endoplasmic reticulum resident protein 44" evidence="11">
        <location>
            <begin position="30"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027258922.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46899" checksum="45513F21EDC29B42" modified="2022-01-19" version="1">MNPAVFLSLPDLRCSLLLLVTSIFTPITAEITSLDSENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEYPDKNQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSNPVQEIQSIDEVTTLDRSKRHIIGYFEQKDSDNYRVFERVASILHDDCAFLSAFGDVSKPERYSGDNLIYKPPGRSVPDMVYLGSMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLETFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQDQDVASSPPESSFQKLAPSEYRYTLLRDRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MUM7</accession>
    <name>A0A8C2MUM7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="18">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Plcb1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16 18">Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:43485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="20">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with DGKQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="18"/>
    <dbReference type="RefSeq" id="XP_027277491.1">
        <property type="nucleotide sequence ID" value="XM_027421690.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303231.1">
        <property type="nucleotide sequence ID" value="XM_035447340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MUM7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028476.1">
        <property type="protein sequence ID" value="ENSCGRP00001024230.1"/>
        <property type="gene ID" value="ENSCGRG00001022157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751979"/>
    <dbReference type="KEGG" id="cge:100751979"/>
    <dbReference type="CTD" id="23236"/>
    <dbReference type="GeneTree" id="ENSGT00940000155428"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099524">
        <property type="term" value="C:postsynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005521">
        <property type="term" value="F:lamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060466">
        <property type="term" value="P:activation of meiosis involved in egg activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071375">
        <property type="term" value="P:cellular response to peptide hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007215">
        <property type="term" value="P:glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048009">
        <property type="term" value="P:insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070498">
        <property type="term" value="P:interleukin-1-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035722">
        <property type="term" value="P:interleukin-12-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035723">
        <property type="term" value="P:interleukin-15-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990806">
        <property type="term" value="P:ligand-gated ion channel signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000438">
        <property type="term" value="P:negative regulation of monocyte extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007207">
        <property type="term" value="P:phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000344">
        <property type="term" value="P:positive regulation of acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048639">
        <property type="term" value="P:positive regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040019">
        <property type="term" value="P:positive regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900087">
        <property type="term" value="P:positive regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010560">
        <property type="term" value="P:positive regulation of glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032735">
        <property type="term" value="P:positive regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099170">
        <property type="term" value="P:postsynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903140">
        <property type="term" value="P:regulation of establishment of endothelial barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080154">
        <property type="term" value="P:regulation of fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099178">
        <property type="term" value="P:regulation of retrograde trans-synaptic signaling by endocanabinoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16208">
        <property type="entry name" value="EFh_PI-PLCbeta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000048">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.240:FF:000004">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
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    <dbReference type="InterPro" id="IPR028400">
        <property type="entry name" value="PLC-beta1_EF"/>
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    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
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    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
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    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
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    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
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    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF12">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 18 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18 21" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8 18 21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="24">
        <location>
            <begin position="540"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="23">
        <location>
            <begin position="656"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="469"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="834"/>
            <end position="892"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1172"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="846"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1075"/>
            <end position="1095"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
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            <position position="331"/>
        </location>
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            <position position="378"/>
        </location>
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    <feature type="binding site" evidence="20">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
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        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
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        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00004126"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    <sequence length="1216" mass="138350" checksum="FA7F3554367CAAFF" modified="2022-01-19" version="1">MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVSPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTSEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVEQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRVAAYEEGGKFIGHRILPVQAIRPGYHYISLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETSSEAPSETRTTPAENGVNHTTSLAPKPPSQAPHSQPAPGSVKAPAKTEDLVQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPGSPDHASSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKETCEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQMELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLAPDPGKGNHRSPSSEEVEGENPGREFDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MW82</accession>
    <name>A0A8C2MW82_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Ccna2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes. Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2). Interacts with CDK2; the interaction increases from G1 to G2. Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm. Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements. Interacts with INCA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027247782.1">
        <property type="nucleotide sequence ID" value="XM_027391981.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MW82"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027338.1">
        <property type="protein sequence ID" value="ENSCGRP00001023093.1"/>
        <property type="gene ID" value="ENSCGRG00001021415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759649"/>
    <dbReference type="KEGG" id="cge:100759649"/>
    <dbReference type="CTD" id="890"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097122">
        <property type="term" value="C:cyclin A2-CDK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097124">
        <property type="term" value="C:cyclin A2-CDK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001939">
        <property type="term" value="C:female pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001940">
        <property type="term" value="C:male pronucleus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20561">
        <property type="entry name" value="CYCLIN_CCNA2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20564">
        <property type="entry name" value="CYCLIN_CCNA2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000037">
        <property type="entry name" value="Cyclin-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032447">
        <property type="entry name" value="Cyclin-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16500">
        <property type="entry name" value="Cyclin_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 13" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="15">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="16">
        <location>
            <begin position="300"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="15">
        <location>
            <begin position="304"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027247782.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47481" checksum="AE78AC8D802F94B9" modified="2022-01-19" version="1">MPGSSRQSGREAGSALVSLQQEDQENVNPEKVAPAQQPRARAALKAGNARGNAPQQRLKTRRVAPLKDLSINDEHVAVGPSWKATSKQPAFTIHVDEEEETQKMPAEHKETQCEDALAFNAAVSLPGARKPLVPLDYPMDGSFESPHAMDMSIVLEDEKPVNVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYSKKQVLRMEHLVLKVLAFDLAAPTVNQFLNQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSLIAGAAFHLALYTVTGQSWPESLVQKTGYTLESLKPCLMDLHQTYLRAAQHAQQSIREKYKHSKYHGVSLLNPPETLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MZV7</accession>
    <name>A0A8C2MZV7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 25">Neutral ceramidase</fullName>
            <ecNumber evidence="5 25">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30 33" type="primary">Asah2</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
            <tissue evidence="33">Liver</tissue>
        </source>
    </reference>
    <reference evidence="30" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells. Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells. This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:41267"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32392"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:74450"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:41269"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:41299"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41300"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:41301"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(hexanoyl)sphing-4-enine + H2O = hexanoate + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:41295"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:63867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41296"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(octadecanoyl)-sphinganine + H2O = sphinganine + octadecanoate</text>
            <dbReference type="Rhea" id="RHEA:45008"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:45009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:41291"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:72956"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41292"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:41293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate</text>
            <dbReference type="Rhea" id="RHEA:38891"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38892"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:38893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate</text>
            <dbReference type="Rhea" id="RHEA:41279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:41280"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-octanoylsphing-4-enine + H2O = octanoate + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:45092"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:45815"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:45093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate</text>
            <dbReference type="Rhea" id="RHEA:41287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:72957"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:41289"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:20857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O</text>
            <dbReference type="Rhea" id="RHEA:43440"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67042"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:43442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="24">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Membrane raft</location>
            <topology evidence="21">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Membrane</location>
            <location evidence="22">Caveola</location>
            <topology evidence="22">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5 25"/>
    <dbReference type="RefSeq" id="XP_035298983.1">
        <property type="nucleotide sequence ID" value="XM_035443092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MZV7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029816.1">
        <property type="protein sequence ID" value="ENSCGRP00001025570.1"/>
        <property type="gene ID" value="ENSCGRG00001023129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765841"/>
    <dbReference type="CTD" id="56624"/>
    <dbReference type="GeneTree" id="ENSGT00390000015792"/>
    <dbReference type="OMA" id="GTTVQTC"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044241">
        <property type="term" value="P:lipid digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000001">
        <property type="entry name" value="N-acylsphingosine amidohydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="25" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="27" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 25" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="28">
        <location>
            <begin position="78"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="29">
        <location>
            <begin position="586"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="23">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_035298983.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="83282" checksum="6AB0CF9BC93D62BD" modified="2022-01-19" version="1">MAKRTFSTLEAFLIFLLVMMTAITVALLTLLFVTSGTIENNKDSGNHGSSTTLSPTTTQTSPITQAPDPPPFQNFSGYYIGVGRADCTGQVSDINLMGYGKRGQNARGLLTRLYSRAFILVEPDGSNRMAFVSVELGMISQRLRLEVLKRLQSKYGSLYRRDNVILSGTHTHSGPAGFFQYTIYVLASEGFSNRTFQYLVSGIVKSIEIAHTNLKPGKIFVNKGNVANVQINRSPSSYLQNPPSERARYSSNTDKEMLLLKMVDLNGEDLGLISWFAIHPVSMNNSNHLVNSDNMGYAAYLFEQEKNRGYLPGQGPFVAGFASSNLGDVSPNILGPHCANTGESCDNEKSTCPVGGPSMCMASGPGQDIFDSTQIIGRMIYQTAKELHDSASQEVTGPVLAAHQWVNMTDVSVMLNDTYAVKTCKPALGYSFAAGTIDGVSGLNITQGTTEGDPFWDTIRDQLLGKPSGEIIECHKPKPILLHTGELTKPHPWHPDIVDVQIVTLGSLAIAAIPGEFTTMSGRRFREAVKKEFESYGMKDMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRDLAKAIATDTVANMSSGPEPPFFNNLIATLIPNIPDRTPIGRHFGDVLQPAKPEYRVGEVVEVTFVGANPKNSAENQTHQTFLTVEKYEDSIGDWQILYNDASWETRFYWHKGTLGLSNATIEWYIPDTAQPGIYRIRYFGHNRKQELLKPAVILAFEGISSPFEVVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N4N8</accession>
    <name>A0A8C2N4N8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Membrane protein MLC1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Mlc1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035295088.1">
        <property type="nucleotide sequence ID" value="XM_035439197.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316431.1">
        <property type="nucleotide sequence ID" value="XM_035460540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N4N8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029174.1">
        <property type="protein sequence ID" value="ENSCGRP00001024928.1"/>
        <property type="gene ID" value="ENSCGRG00001022695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758882"/>
    <dbReference type="KEGG" id="cge:100758882"/>
    <dbReference type="CTD" id="23209"/>
    <dbReference type="OMA" id="KAWRAVM"/>
    <dbReference type="OrthoDB" id="8806209at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097450">
        <property type="term" value="C:astrocyte end-foot"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032388">
        <property type="term" value="P:positive regulation of intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033280">
        <property type="entry name" value="Membrane_MLC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17597">
        <property type="entry name" value="MEMBRANE PROTEIN MLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17597:SF0">
        <property type="entry name" value="MEMBRANE PROTEIN MLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035295088.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42213" checksum="A243EC140F07F085" modified="2022-01-19" version="1">MPVSSAMTREGQFREELGYDRMPTLERGRQDTGRQDAGSYTPDSKPKDLQLSKRLPPCFSYKTWVFSVLMGSCLLVTSGFSLYLGNVFPSEMDYLRCAAGSCIPSAIVSFAVGKRNVSAIPNFQILFVSTFAVTTTCLIWFGCKLILNPSAININFNLILLLLLELLMAATVIISARSSEESCKKKKVSISDGTNILDEVTFPARVLKSYSVVEVIAGVSAVLGGVIALNVDEAVSGPHLSVTFFWILVACFPSAIASHVTAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSVMRIVEIFKDYPPAIKSYDVLLLLLLLVLLLQGGLNTGTAIQCVSFKVSTQQQAASWDTQTCPQERPAGEVARSPLKEFDKEKAWRAVVVQMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QCG7</accession>
    <name>A0A8C2QCG7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hook microtubule tethering protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Protein Hook homolog 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Hook1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hook family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027256233.1">
        <property type="nucleotide sequence ID" value="XM_027400432.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QCG7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001467.1">
        <property type="protein sequence ID" value="ENSCGRP00001001390.1"/>
        <property type="gene ID" value="ENSCGRG00001001100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766023"/>
    <dbReference type="KEGG" id="cge:100766023"/>
    <dbReference type="CTD" id="51361"/>
    <dbReference type="GeneTree" id="ENSGT00940000159251"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070695">
        <property type="term" value="C:FHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905198">
        <property type="term" value="P:manchette assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905719">
        <property type="term" value="P:protein localization to perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22225">
        <property type="entry name" value="HkD_Hook1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000024">
        <property type="entry name" value="Hook homolog 3 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF36">
        <property type="entry name" value="PROTEIN HOOK HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="173"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="479"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027256233.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="84567" checksum="0AE8D2C59F42F471" modified="2022-01-19" version="1">MEDPQPLPQPELPLCDSLIIWLQTFKTASPCQDVKQLTNGVTMAQVLHQIDVAWFSESWLSRIKDDVGDNWRIKASNLKKVLHGITSYYHEFLGQQISEELIPDLNQITECSDPVELGRLLQLILGCAVNCERKQEHIKTIMTLEESVQHVVMTAIQELMSKEIVSSPAGDTVGELEQQLKRALEELQEAVAEKEELKQRCQELDMQVTALQDEKNSLVSENEMMNEKLDQLDGSFDDPNTMVAKKYFHAQLQLEQLQEENYRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRTTSDKANKLESTVEVYRQKLQDLNDLRKQVKSLQETNMMYMHNTVSLEEELKKANAVRAQLETYKRQVQDLHTKLSSESKRADILAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQAQQDHLNQADASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGTENERIEQLQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQDQGSKTEGETSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDISQNVQKISELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSAWYNKSLAFQKLGMESRLVSGTGACKDTGSGPPARSFLAQQRHITNTRRNLSVKVPAAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QFN2</accession>
    <name>A0A8C2QFN2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor Sp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Sp2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027279992.1">
        <property type="nucleotide sequence ID" value="XM_027424191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QFN2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012906.1">
        <property type="protein sequence ID" value="ENSCGRP00001008762.1"/>
        <property type="gene ID" value="ENSCGRG00001010976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762021"/>
    <dbReference type="KEGG" id="cge:100762021"/>
    <dbReference type="CTD" id="6668"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22540">
        <property type="entry name" value="SP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000421">
        <property type="entry name" value="Sp2 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000455">
        <property type="entry name" value="Transcription factor Sp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027279992.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="64733" checksum="2608553B6EC33A7E" modified="2022-01-19" version="1">MSDPQMSMAATAAVSPSDYLQPAAATTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPSKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTVINKGSRSNASIQYQAVPQIQGNSSQSIQVQPNLANQIQIIPGTNQAIITPSSSGHKPVPIKPAPVQKSNTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNTSDAGAPAQLLTESPPTPLSKTSKKARKKSLPVSQPSVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQTTESAPTQVYIRTPSGEVQTVLVQDSPPATAAATSTTTCNSPAPRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGEAQPGEKKRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QLU0</accession>
    <name>A0A8C2QLU0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Ubiquitin carboxyl-terminal hydrolase 32</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Deubiquitinating enzyme 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ubiquitin thioesterase 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Ubiquitin-specific-processing protease 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 30" type="primary">Usp32</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1. Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_016830277.2">
        <property type="nucleotide sequence ID" value="XM_016974788.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282193.1">
        <property type="nucleotide sequence ID" value="XM_027426392.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001025382.1">
        <property type="protein sequence ID" value="ENSCGRP00001021138.1"/>
        <property type="gene ID" value="ENSCGRG00001020062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763480"/>
    <dbReference type="KEGG" id="cge:100763480"/>
    <dbReference type="CTD" id="84669"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000081">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000128">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000068">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2230.10:FF:000004">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000018">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000065">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000076">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057368">
        <property type="entry name" value="USP32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25265">
        <property type="entry name" value="USP32_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 30" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="26">
        <location>
            <begin position="369"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="25">
        <location>
            <begin position="734"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1353"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1360"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1371"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027282193.1"/>
        </source>
    </evidence>
    <sequence length="1604" mass="181351" checksum="7A3D2DEAD294EE4A" modified="2022-01-19" version="1">MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMSQHCFIREVLGDGVPPKVAEVIYCSFGGTSKGLHFNNLIVGLVLLTRGKDEEKAKYIFSLFSSESGSYVVREEMERMLHVVDGKVPDTLRKCFSEGEKVNYEKFRNWLLLNKDAFTFSRWLLSGGVYVTLTDDSDTPTFYQTLAGVTHLEESDIIDLEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAFDENRDNHIDFKEISCGLSACCRGPLAERQKFCFKVFDVDRDGVLSRVELKDMVVALLEVWKDNRTDDIPELHMALSDIVEDILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVCHIVLGLRPATPEEEGQIIRGWLERESRYGLQPGHNWFIISMQWWQQWKEYVKYDTNPVVIEPSSVLNGGKFSFGAAAHPMEQGEDRISNSLSYVNTTEEKYSDNISSASEASESTGSGFLYSGTPGADMCFARQHNTSDNNNQCLLGANGNILLHLNPQKPGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLALPRPVIKNSKTDIPELELFPRYLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLRIKEEDMRLWLYNSENYLTLLDDEDHRLEYLKIQDEQHLVIEVRNKDMSWPEEMSFIANSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPIRYGLRLNMDEKYTGLKKQLSDLCGLKSEQILLAEVHSSNIKNFPQDNQKVRLSVSGFLCAFEIPILASPVSACSPVQTDCSSSPSSNGLFTLTANGDLPRPIFIPNGMPNTVVPCGTEKNVTNGMVNGHMPALPDDPFTGYIIAVHRKMMRTELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASNHAQDCDDSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNACIAVDWDPTALHLRYQTSQERVVEEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLVPRDPALCQHKPLTPQGDDISELRISGGDVKKMDVQNSAGEDDVLLSKSPSSLSANITSSPKGSPSSSRKSGASCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKLSSSKENLDASKENGAGQTCELADTLSRGHMLGGSQPELVTPLDHESTLANGFLYEHEACGNGYSNGQLGNHSEEDITDDQREDTHSKPIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQGIDCAQFLPKIDGKKMADTSSMDEDFESDYKKYCVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QMS6</accession>
    <name>A0A8C2QMS6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Max-binding protein MNT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Myc antagonist MNT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein ROX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Mnt</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027282576.1">
        <property type="nucleotide sequence ID" value="XM_027426775.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QMS6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027322.1">
        <property type="protein sequence ID" value="ENSCGRP00001023077.1"/>
        <property type="gene ID" value="ENSCGRG00001021405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766817"/>
    <dbReference type="KEGG" id="cge:100766817"/>
    <dbReference type="CTD" id="4335"/>
    <dbReference type="GeneTree" id="ENSGT00510000048287"/>
    <dbReference type="OrthoDB" id="5981879at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11402">
        <property type="entry name" value="bHLHzip_Mnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000034">
        <property type="entry name" value="MAX network transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF99">
        <property type="entry name" value="MAX-BINDING PROTEIN MNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="14">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027282576.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="63187" checksum="C0423FAFCC86182A" modified="2022-01-19" version="1">MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREREQEQKRASSLARLAHALPVEEPRIEAPALPLSPPAPPPAPPPPLATPTPLTVIPIPVVTNSPQSLPPPPPLPPAAQPLPLAPRQPALVSTPGLSIKEPVPLPTRPQVPTPTPLLPDTKTTAAPTGSPKPLQPLPTPILTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEAKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNVDEDMEEDRAGLGPPELSHRPQPELLKSTLPSPSATSAPLPAHPHPHPHPVALSPAHLPVQQPPPQQKTPLPAPPPPPATPTQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPTTVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F824</accession>
    <name>A0A9J7F824_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Ing5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027253487.1">
        <property type="nucleotide sequence ID" value="XM_027397686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F824"/>
    <dbReference type="GeneID" id="100755543"/>
    <dbReference type="KEGG" id="cge:100755543"/>
    <dbReference type="CTD" id="84289"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16863">
        <property type="entry name" value="ING_ING5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15685">
        <property type="entry name" value="PHD_ING5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000016">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF41">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="209"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027253487.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30393" checksum="DB2739228E230F8F" modified="2023-06-28" version="1">MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEASSHQHLGCMSLYLLLPLLTCLSDKKAEIDILAAEYISTVKTLSSEQRVEHLQKIQSAYNKCKEYSDDKVQLAMQTYEMVDKHIRRLDADLARFEADLKDRMDGSDFESTGPRSLKKGRSQKEKRSSRGRGRRTSEEDTPKKKKHKSGSEFTDSILSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVDLTTKPKGKWFCPRCVQEKRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F9H4</accession>
    <name>A0A9J7F9H4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Vacuolar protein sorting-associated protein 13D isoform X6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">Vps13d</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7 8">17A/GY</strain>
            <tissue evidence="7 8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027253955.1">
        <property type="nucleotide sequence ID" value="XM_027398154.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253956.1">
        <property type="nucleotide sequence ID" value="XM_027398155.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100755898"/>
    <dbReference type="KEGG" id="cge:100755898"/>
    <dbReference type="CTD" id="55187"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23453">
        <property type="entry name" value="beta-trefoil_Ricin_VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14306">
        <property type="entry name" value="UBA_VP13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000057">
        <property type="entry name" value="Vacuolar protein sorting 13 homolog D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041969">
        <property type="entry name" value="VP13D_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="2631"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1566"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1745"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1844"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2071"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1854"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2075"/>
            <end position="2084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027253955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027253956.1"/>
        </source>
    </evidence>
    <sequence length="4386" mass="489927" checksum="89DE41D0CE79493F" modified="2023-06-28" version="1">[encoded data, 4386 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FA82</accession>
    <name>A0A9J7FA82_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger MYM-type protein 4 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Zmym4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027255109.1">
        <property type="nucleotide sequence ID" value="XM_027399308.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100766296"/>
    <dbReference type="KEGG" id="cge:100766296"/>
    <dbReference type="CTD" id="9202"/>
    <dbReference type="OrthoDB" id="10025028at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057926">
        <property type="entry name" value="QRICH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010507">
        <property type="entry name" value="Znf_MYM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051284">
        <property type="entry name" value="ZnF_MYMT-QRICH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736:SF5">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25561">
        <property type="entry name" value="QRICH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24900">
        <property type="entry name" value="TRASH_ZMYM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06467">
        <property type="entry name" value="zf-FCS"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="486"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="579"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="687"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="729"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="772"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="816"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1161"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027255109.1"/>
        </source>
    </evidence>
    <sequence length="1549" mass="172931" checksum="52495084BDA1D592" modified="2023-06-28" version="1">MAEREVETGPRKRFEQKSDAVFDEIVENCGVMDTEMSEDTDHNLTPTLASMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVSSDNEDEQDFSSKDNLVSSIHTDDSLEVERRASHHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFCLVRENSKETFPGKEKNRDLTYHEREKRLDKPHKGLDSRLKSSFFDKAANQVEETLHTHLPQNPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAVAPQQGLLDRVKDEPENAQEYNHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASPGMNKMLPSVPAAAVRVSCSGCKKILQKGQTAYQRKGSTQLFCSTLCLTGYTVPPARLPPLLTKKTCSSCSKDILNPKDVISAQFENSTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHVLQIEGQSKKFCSSMCVTSYKQKSAKITPCALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSAVSAGGGNTPAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLRCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNVMAMCEYCKIEKIIKETVRFSGADKSFCSEGCKLLYKHDLGKRWGSHCKMCSYCLQTSPKLIQNNLGGKVEDFCCEECMSKYTVLFYQMAKCDGCKRQGKLSESLKWRGEIKHFCNLLCILMFCHQQTVCDPPLQNNSASISMVQATSAGPPSLRKDSTPVIANVVSLASAPAAQPTANANSVLQGAVPTVTAKIIGDASTQTDTLKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSEPQVMVVPVPVPVFVPIPLHLYTQYTPVPFGIPVPMPVPMLIPSSMDNEDKATESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKEKSLSQGESQTSEQELFLDTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSESFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSVVPVEPRSLIQGALQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGGEHASPSPGSDSLGSVQDQALSQESSEQGCKVRPVKLKEDILSCTFSELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPDKLTIGKRKRNEDDEAPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDIELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FAG9</accession>
    <name>A0A9J7FAG9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Insulin receptor substrate 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Irs1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
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            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
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                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">17A/GY</strain>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
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                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">17A/GY</strain>
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            <strain evidence="8">17A/GY</strain>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027257686.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="29491" checksum="03918F62AF47E06A" modified="2023-06-28" version="1">MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHHQESRLNSVSSTQGDMVQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKINGRERKRMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGHHSAFHCGTVGHSAGHPAHAANAVHPVHPILGGALSSGNATSPLSAASLPAIGTIRPPHSLLKAPSTPPALQLGSGFQHWAGLPCPCTICQMPPPPHLSALSTANMARLSTESKDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FJN0</accession>
    <name>A0A9J7FJN0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Slc7a6os</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027261719.1">
        <property type="nucleotide sequence ID" value="XM_027405918.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FJN0"/>
    <dbReference type="GeneID" id="100760110"/>
    <dbReference type="KEGG" id="cge:100760110"/>
    <dbReference type="CTD" id="84138"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027261719.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34797" checksum="191D8CD864328C15" modified="2023-06-28" version="1">MEAGRTAVLRVKRKRSAEPVEALVLACKRLRSGEVESSAQETPQGPEAAAESNVFQLVATVRSQEEPIQQLVRAALRPSRSSQLRIRRDLRASVREVRKEGRYRVVSSHRSSGISSGSEPPCMSEDAGDAGFQLLDLVHEEGDPEAAATDCCKTSDPDVILCNSVELIRERLTVSEDEPQVEHQKESKHNDDYVYDIYYMEMAPPGWIENILSVQPYSQEWELVNDDQQPEDTYEDEDDENSENNWRNEYPDEESSDEDEDSRDSNEYNSLSEEERGSRQLMWSKYPLDVQKEFGYDNPHDLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FRZ8</accession>
    <name>A0A9J7FRZ8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P2Y purinoceptor 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">P2ry11</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027267269.1">
        <property type="nucleotide sequence ID" value="XM_027411468.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309965.1">
        <property type="nucleotide sequence ID" value="XM_035454074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FRZ8"/>
    <dbReference type="GeneID" id="113835257"/>
    <dbReference type="KEGG" id="cge:113835257"/>
    <dbReference type="CTD" id="5032"/>
    <dbReference type="OMA" id="MYQVSKG"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045031">
        <property type="term" value="F:G protein-coupled ATP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15376">
        <property type="entry name" value="7tmA_P2Y11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000283">
        <property type="entry name" value="Purinergic receptor P2Y11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027677">
        <property type="entry name" value="P2Y11_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF46">
        <property type="entry name" value="P2Y PURINOCEPTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="42"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023040"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027267269.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40420" checksum="964DB0178D21CECA" modified="2023-06-28" version="1">MAAFSGDCPEKYVEAAEQEYRRFQEGYLWAILMAEFLVAVGGNGLALFRFITQEQRPWNPAVVFSAQLAVSNLCYSFTLPPLAAYFYPPKNWSFGEVACRLERFVFTCNLLGGIIFITCISLSRYMVVVHPFFTRRHLRPKHAWVISAASWAMAILLAAPMLGFSHQNQPQSKPGSCNNTNREACVKCLGMMEDSQIETFRNYSLVLACLGGILPLLLTLMAYSALGSVVLRSLSMTTAQKLHVVVLVTSGVALYACSYVPYHITQVLYVNSLLSWKALCPGFSTESQAKAALNPRAFFGYQTTRILVPLATCMHPLLYMAVAPSLNCHSCHGDPEDQSPHQDLPLASATTSQSQLSPEASSSQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FTD6</accession>
    <name>A0A9J7FTD6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alpha-tectorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC100753259</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin. Interacts with CEACAM16.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027411879.2"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Alpha-tectorin"/>
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        <property type="entry name" value="LRR_dom_sf"/>
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        <property type="entry name" value="TILa_dom"/>
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    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
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        <property type="entry name" value="VWF_dom"/>
    </dbReference>
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        <property type="entry name" value="VWF_type-D"/>
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    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
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    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
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    <dbReference type="InterPro" id="IPR001507">
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        <property type="entry name" value="ZP_dom_CS"/>
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    <dbReference type="PANTHER" id="PTHR46160:SF3">
        <property type="entry name" value="ALPHA-TECTORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160">
        <property type="entry name" value="ALPHA-TECTORIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="C8"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12714">
        <property type="entry name" value="TILa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00682">
        <property type="entry name" value="ZP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-1009">Hearing</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NIDO" evidence="18">
        <location>
            <begin position="417"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="639"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
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            <end position="1205"/>
        </location>
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    <feature type="domain" description="VWFD" evidence="19">
        <location>
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            <end position="1597"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="1804"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="17">
        <location>
            <begin position="2119"/>
            <end position="2373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058814"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064198"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070182"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51034"/>
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        <source>
            <dbReference type="PROSITE" id="PS51220"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027267680.2"/>
        </source>
    </evidence>
    <sequence length="2469" mass="274928" checksum="8C29CDB56636930C" modified="2023-06-28" version="1">MDQPSGRSFMQVLCEKYSPENFPYRRGPGMGVHVPATPQGSPMKDRLNLPSVLVLNSCGITCAGDEREIAAFCAHVSELDLSDNKLEDWHEVSKIVSNVPQLEFLNLSSNPLNLSVLERTCAGSFSGVRKLVLNNSKASWETVHTILQELPDLEELFLCLNDYETVSCPSVCCHSLKLLHITDNNLQDWTEIRKLGVMFPSLDTLVLANNHLNAIEEPADSLARLFPNLRSISLHKSGLQSWEDIDKLNSFPKLEEVRLLGIPLLQPYTTEERRKLVVARLPSVSKLNGSVVTDGEREDSERFFIRYYVDVPQEEVPFRMNYSSLLRIWVSFIFALVQHQAQPRELMYPFWQNDTKTPKVDDGSSSEIKLAIPVFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFIAPFWADVHNGIRGEIYYRETMDPAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTNFFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEIDPANGCTSRGQFLRRGEVFWDDLNCTIKCRCLDFNNEIYCQEASCSPYEVCEPKGRFFYCSPVETSTCVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELSVEVNGYKILIPKGSYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLLVTFDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCGSGCVDNCTQCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTCSDLTASQNCATPCTEGCECNEGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQCLCEEGGDVYCFNKTCRSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPSEFSYTLLKTCPERPEYLEIDINKKKPDVGPAWLRGLRILVADQEVKIGGVGALEVKLNGQDVELPYFHPSGRLEIYRNKNSTTVESKGVVTVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRGRSRCGIINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCPLECPENSHFEECMTCTETCETLALGPICVDSCSEGCQCDEGYALQGSQCVTRSECGCNFEGHQLATNETFWVDQDCQIFCYCNGTDNSVHCETIPCRDDEYCMEESGLYYCQPRTDASCIVSGYGHYLTFDGYAFDFQTSCPLILCTTGSRSISDSIPKFIVTAKNEDRDPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNNERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVVYDWKTFLSITVPRSMQNNTYGLCGRYNGNPDDDLEMPMGLLALSINEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAGFAKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTSCTVTCPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLNGKSCILPHNCGCYSDGKYYEPKQLFWNGDCTRRCRCFRRNLIQCDPRQCKSDEECALRSGVRGCFSTKTSYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNLTIISPVYFYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNIIKISISERLQNKVCGLCGNFNGDMTDDYVTLRGKPVVSSVVLAQSWKTNGMQKSCNELQFSQYAATCDNAHIQTMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNHKKFQLCGSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELDNGGELCGCIEPPPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRINDRQCTGIEGEDFISFQINNTKGNCGNIVQSNGTHIMYKNTIWIESANNTGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLYVGVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIGIEENGVSLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKINCPQNSRIATDYTKEPKEQIISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLCSCVTGSLQEDGRSCRASNSSVELQVWTLLLIMTQITLWNFVYKSGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FUF7</accession>
    <name>A0A9J7FUF7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LOW QUALITY PROTEIN: retinol-binding protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Rbp1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027266693.2">
        <property type="nucleotide sequence ID" value="XM_027410892.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FUF7"/>
    <dbReference type="GeneID" id="100762475"/>
    <dbReference type="KEGG" id="cge:100762475"/>
    <dbReference type="CTD" id="5947"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002138">
        <property type="term" value="P:retinoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006776">
        <property type="term" value="P:vitamin A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19462">
        <property type="entry name" value="CRBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031264">
        <property type="entry name" value="CRBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="4">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027266693.2"/>
        </source>
    </evidence>
    <sequence length="198" mass="22512" checksum="EB51A93D488BCB4B" modified="2023-06-28" version="1">MDSPAGFVRTRIPAVAAPRSPVSPEGAHFRAAHHSERIGSLRPGRPTVAPAFSVSDHPYSVPKMPVDFNGYWKMLSNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRAQGVICKQVFKKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FXH4</accession>
    <name>A0A9J7FXH4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Teratocarcinoma-derived growth factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Tdgf1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003506710.1">
        <property type="nucleotide sequence ID" value="XM_003506662.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270514.1">
        <property type="nucleotide sequence ID" value="XM_027414713.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FXH4"/>
    <dbReference type="GeneID" id="100767483"/>
    <dbReference type="KEGG" id="cge:100767483"/>
    <dbReference type="CTD" id="6997"/>
    <dbReference type="OrthoDB" id="9893603at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070697">
        <property type="term" value="F:activin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038092">
        <property type="term" value="P:nodal signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000421">
        <property type="entry name" value="Teratocarcinoma-derived growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019011">
        <property type="entry name" value="Cryptic/Cripto_CFC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09443">
        <property type="entry name" value="CFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039905161" evidence="8">
        <location>
            <begin position="26"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027270514.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19879" checksum="7E12ABDAFA478A2A" modified="2023-06-28" version="1">MEHFSSSLVLLLVISGAFEFGLIAGLDHHEVTILSPRDLAIRDNSLRNPEGPAVHSQSFKLVPSVGIQNSKLLNKTCCLNGGTCILGSFCACPPSFYGRNCERDVRKEHCGSVLHGNWLPKKCSLCRCWHGQLHCFPQTFLPGCDGHVMDQDLPASRTPGQAPSVPTTFMLAGICLFLEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FXR8</accession>
    <name>A0A9J7FXR8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane epididymal protein 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC100750611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269174.1">
        <property type="nucleotide sequence ID" value="XM_027413373.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FXR8"/>
    <dbReference type="GeneID" id="100750611"/>
    <dbReference type="KEGG" id="cge:100750611"/>
    <dbReference type="OrthoDB" id="551896at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46441">
        <property type="entry name" value="TRANSMEMBRANE EPIDIDYMAL FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46441:SF3">
        <property type="entry name" value="TRANSMEMBRANE EPIDIDYMAL FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027269174.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33934" checksum="55BB9B2B6706A814" modified="2023-06-28" version="1">MGTLEGHLMPGVGFLLYSLYYSVLTSLALLREQKVLKHPMLPRKLCGHRLLPQVSYEALIKVLMGTLTVVCELFYPPGENRLQMIDWKDPRRPFIFKDNWQHVTMFGFFAFSGVVDLVSQSRLVRSWGEKLEHAAEALAFYVLVVLMATHTENKSSLEIRVHLLLMVPSFLLALVTTVEVWLPNHPPIWILKCLLGLVFSNWLFQICEMYVPLTGQPWRSDSPADRAFLSVFFCWYIAFSIALFIAVYGLCSLWHCHYSSWKKTPGARYQRCRIESSCEELEKLKAEALLQDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FYV6</accession>
    <name>A0A9J7FYV6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Huntingtin-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Huntingtin-interacting protein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Hip1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Binds actin. Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds to IFT57. In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57. Interacts with CLTB (via N-terminus). Interacts (via coiled coil domain) with AR. Interacts with AP2A1, AP2A2, CLTC and HIP1R. Interacts with GRIA1, GRIN2A and GRIN2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003500976.1">
        <property type="nucleotide sequence ID" value="XM_003500928.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271983.1">
        <property type="nucleotide sequence ID" value="XM_027416182.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FYV6"/>
    <dbReference type="GeneID" id="100757209"/>
    <dbReference type="KEGG" id="cge:100757209"/>
    <dbReference type="CTD" id="3092"/>
    <dbReference type="OMA" id="SSCTEQL"/>
    <dbReference type="OrthoDB" id="8178130at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048260">
        <property type="term" value="P:positive regulation of receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17013">
        <property type="entry name" value="ANTH_N_HIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000002">
        <property type="entry name" value="Huntingtin interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000002">
        <property type="entry name" value="Huntingtin interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000022">
        <property type="entry name" value="huntingtin-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032422">
        <property type="entry name" value="HIP1_clath-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF14">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16515">
        <property type="entry name" value="HIP1_clath_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ENTH" evidence="23">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="24">
        <location>
            <begin position="771"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1014"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="377"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027271983.1"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116291" checksum="0C0DAA76A54E13A3" modified="2023-06-28" version="1">MDRMASSMKQVPNPLPKVLSRRGVGAGMEAAERESFERTQTVSVNKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAMLCWKFCHVFHKLLRDGHPNVLKDSLRYKNELSDMSRMWGHLSEGYGQLCSIYLNLLRTRMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTTAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFQRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEVSSPDSEPVLEKDDLMDMDAAQQNLFDNKFDDIFGSSLSSDPFNFNNQNGVNKDEKDHLIERLYREISGLTGQLDSVKMESQRAMLQLKGRVSELEAELAEQQHLGRQATDDCEFLRTELDELKRQREDTEKAQRSLTEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSVARQAQVDLEREKKELEDSFARVSDQAQRKTQEQQDVLENLKHELASSRQELQVLHSSLETSAQSEAKWLTQIAELEKEQGSLVTAAAQREEEFSALRDQLESTKIKLASAQESMCQQVKDQRKILLAGSRKAAEREIQEALSQLEEPALISCAGSTDHLLSKVKAVSSCLEQLEKSCSQYLACPEDISELLHSITLLANLTSDTIIQGSATSLRAPPEPADSLTEACRQYGKETLAYLFSLEEEEAMEKADSTAMKNCLRKIEAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIEAATNRIEEILSKSRAGDTGVKLEVNERILGSCTSLMQAIKVLVVTSKDLQKEIVESGRGTASHKEFYAKNSRWTEGLISASKAVGWGATIMVDAADLVVQGKGKFEELMVCSHEIAASTAQLVAASKVKANKGSLNLTQLQQASRGVNQATAAVVASTISGKSQIEETDSMDFSSMTLTQIKRQEMDSQVRVLELENDLQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTAQEAIPEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G582</accession>
    <name>A0A9J7G582_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Amine oxidase</fullName>
            <ecNumber evidence="24">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">Il4i1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:51404"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58489"/>
            <dbReference type="EC" id="1.4.3.25"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:51405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-phenylalanine + O2 + H2O = 3-phenylpyruvate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:61240"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:61241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:61244"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:61245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosine + O2 + H2O = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:61248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:61249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>an L-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="1.4.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13782"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="22">Amino-acid degradation; L-tryptophan degradation via pyruvate pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Acrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flavin monoamine oxidase family. FIG1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="24"/>
    <dbReference type="RefSeq" id="XP_016835382.1">
        <property type="nucleotide sequence ID" value="XM_016979893.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276531.1">
        <property type="nucleotide sequence ID" value="XM_027420730.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G582"/>
    <dbReference type="GeneID" id="100773063"/>
    <dbReference type="KEGG" id="cge:100773063"/>
    <dbReference type="CTD" id="259307"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002841">
        <property type="term" value="P:negative regulation of T cell mediated immune response to tumor cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045591">
        <property type="term" value="P:positive regulation of regulatory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000004">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000450">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.660.10:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF21">
        <property type="entry name" value="L-AMINO-ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 24" id="KW-0274">FAD</keyword>
    <keyword evidence="7 24" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 24" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Amine oxidase" evidence="26">
        <location>
            <begin position="167"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027276531.1"/>
        </source>
    </evidence>
    <sequence length="743" mass="82714" checksum="D01658CA37FBFFE8" modified="2023-06-28" version="1">MPSGPTGHHCPSLRLRGRGSWLPVSPPPRGWSVKPRELWERAGKAVGEGGASGYSLHGCGKERRRRRPRLNRRRERRVQARKNTGRCPASLAGLIINYHEDNKAPRLVLVAALLGLVASLDWRMASSLNPFEKCMEDPDYEQLLKVVTLGLNRTLKPQKVVIVGAGVAGLTAAKVLSDAGHKVTILEAGNRIGGRILTYRDGKTGWVGELGAMRMPSSHRILHMLCRSLGLNLTQFTQYDENTWTEVNDVKLRNYVVEKMPEKLGYDLSHREKGHSPEDIYQMALDKALKYLKVMGCKKAMKKFHRHTLLEYLTGEGNLTWPAVQLLGDVMSKEGFFYLSFAEALRAHSCLSDRLRYSRIVGGWDLLPRALLSSLSGPVLLNAPVVAITQGIHDVRVHIATSLQPHSLKSMTADLVLLTASGPALQRMTFSPPLTRRRQEALRGLHYVAATKVFLSFHRPFWNEEHIEGGHSNTDRPARLIFYPAPGEGALLLASYTWSDAAAPFAGLSTEQALHVALKDVAALHGPVVYRLWDGTGVVKHWAEDPHSQGGFVVQPPLLGQGNEDYDWAFPYGRIYFAGEHTAYPHGWVETAVKSALRAAVKINNHGFRLEKLKHASFQKQGHIHSETRLDQDEAGLNEEQETRPGGHVFVEAIPELRGHVYVETIPQGKGHVHLHPKIVPPHVHMHEELIPGRRVQMHGGHRHGTSGSQKFPHLHSYCKASRVIPPPIRSPLEQATHSNSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G878</accession>
    <name>A0A9J7G878_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin trafficking protein CblD isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Mmadhc</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027276257.1">
        <property type="nucleotide sequence ID" value="XM_027420456.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G878"/>
    <dbReference type="GeneID" id="100751326"/>
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    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_027276257.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36755" checksum="01FFEC4E9A66B0B9" modified="2023-06-28" version="1">MVPARGLPCTSRGDRNPAGFFAKGRNLRPSSSLEMAHVLCNRARLVSYLPGFCSLVKRVISPKAFSTAGSSGSDESHVATAPPDICSRTVWPDETMGPFGPQDQRFQLPGNMGFDCHLNGTASQKKSLTHKTLPDVLAEPLSTERHEFVMAQYVNEFQSSDAPVEQEINSAETYFESARVECVIQTCPELLQRDFETLFPEVANNKLMILTVTQKTENDMTAWSEEVEVEREMLLEKFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVFVGSIFTNAAADSHIMRKLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GBR3</accession>
    <name>A0A9J7GBR3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Unconventional myosin-XIX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">Myo19</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13 14">17A/GY</strain>
            <tissue evidence="12 13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. Motor protein that moves towards the plus-end of actin filaments. Required for mitochondrial inheritance during mitosis. May be involved in mitochondrial transport or positioning.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016830272.1">
        <property type="nucleotide sequence ID" value="XM_016974783.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016830273.1">
        <property type="nucleotide sequence ID" value="XM_016974784.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016830274.1">
        <property type="nucleotide sequence ID" value="XM_016974785.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282195.1">
        <property type="nucleotide sequence ID" value="XM_027426394.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282196.1">
        <property type="nucleotide sequence ID" value="XM_027426395.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282197.1">
        <property type="nucleotide sequence ID" value="XM_027426396.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GBR3"/>
    <dbReference type="GeneID" id="100759803"/>
    <dbReference type="KEGG" id="cge:100759803"/>
    <dbReference type="CTD" id="80179"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14880">
        <property type="entry name" value="MYSc_Myo19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000013">
        <property type="entry name" value="Unconventional myosin-XIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000014">
        <property type="entry name" value="unconventional myosin-XIX isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036035">
        <property type="entry name" value="MYSc_Myo19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF289">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="35"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027282195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027282196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027282197.1"/>
        </source>
    </evidence>
    <sequence length="977" mass="109372" checksum="477761D28EFDABC1" modified="2023-06-28" version="1">MLQQVNGHSSGTDAEGKASLKGDLQQFLDGEAPLHQLDDLTKVNPVTLETVLRCLQARYTEDIFYTNAGCTLVALNPFKPIPQLYAPELMQEYHAAPQPQKLKPHIFTVGEQTYRNVKSLIKPINQSIVVSGESGAGKTWTSRCLMKFYAVVASSSASCENHKMAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRVACQASNERNFHIFYQICKGATKDERLQWYLPEGAAFSWLPNPENNLEEDCFELTREAMLHLGIDTPTQNNIFKDFKPHRTISKELAITVLAGLLHLGNVHFTDSEDEAQPCQLMDGTKVSVRTSASLLHLQEDLLLETMQIRTIKAGKQQQVFRKPCSRAECDTRRDCLAKLIYARLFNWLVSVINSSICADSSSWTAFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLKAQQEEYAVEGLEWSFVNYQDNQTCLDLLEGSPISICSLINEECRLNRPSSAAQLQSRIESALAGKPCLGHNKLSREPSFVVVHFAGPVRYHTEGLVEKNKDPVPPELTGLLQQSQDPLLMMLFPDNPEEKTQEELSGQSRVPALTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQSKPQTFLQKEVLSQLEACGLVETIHISAAGFPIRVSHQNFVERYKLLRRLRPRTSSGLQGLCPARGPSEQPLCAKDATLQPPLQDILHALPALIQTATTPSDPAETTQVPLYCGRTKIFMTDSMLELLECGRAQMLEQCARCIQCGWRRHQLQKQKKQRQAAVLIQAAIRSWLTRKHIQRLHIAATVIKRAWHKWRIRMACLAAKELDGMEEKPMTQTPSSLSSSLPPAHTNLLGAIIHLWPLGLVLANSAVGVRGFQRKLVAYACLRLPSSSPSNNIQTAQDQAGITSIRALPQGSIKFHCRKSPLQYADICPEPSASSVSGFNQILLERNRPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GBZ1</accession>
    <name>A0A9J7GBZ1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Kif2b</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027281914.1">
        <property type="nucleotide sequence ID" value="XM_027426113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GBZ1"/>
    <dbReference type="GeneID" id="100760507"/>
    <dbReference type="KEGG" id="cge:100760507"/>
    <dbReference type="CTD" id="84643"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF24">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="213"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="303"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027281914.1"/>
        </source>
    </evidence>
    <sequence length="668" mass="75542" checksum="E6B976EAEB5D5492" modified="2023-06-28" version="1">MSSQFCVPLAPRLSPLKPLKSHFTDFQVGICVAIQRSDKRIHLAVVTEINRENSWVTVEWVEKGVKKGKKIELETVFLLNPALASAEHQRSHRSLRTVSVTPSTIIGDQRTATKWIAMIPHRNESPSGDSQAMVVPSNPCLMKRKKSPCLREIEKLQKQREKRRRLQLEIRARRALDINTGNPNYETMRMIEEYRRNLDSSKMSSLEPPEDHRICVCVRKRPLNERETIMKDLDIITIPSHNVVMVHESKQKVDLTRYLENQTFCFDHAFDDTASNELVYQFTARPLVESIFRKGMATCFAYGQTGSGKTHTMGGAFTGKAQDCSKGIYALVAQDVFLLLRSPAYEKLELKVYGTFFEIYGGKVYDLLNWKKKLQVLEDGNQQVQVVGLQEQEVSRVEEVLNLVELGNGCRTSGQTSVNAHSSRSHAVFQLILKSEGKLHGKFSLVDLAGNERGADTAKANRKRQLEGAEINKSLLALKECIRALGKNKSHTPFRASKLTQVLRDSFIGQNSSTCMIATISPGMTSCENTLNTLRYANRVKELALEARPYHHCLSPADHEVPLELEKDNTNSKTSCAGKEFIKIPTEHNVEENESDNITLIKDPVASWRRPNRWWEAIQETADGVNCDVDFCIAQSLSILEQKIGVLTEIQKKLQLLRADLQKKSQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GEK6</accession>
    <name>A0A9J7GEK6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12 13">Bromodomain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC113836825</name>
        <name evidence="10" type="synonym">LOC113832446</name>
        <name evidence="11" type="synonym">LOC113832901</name>
        <name evidence="12" type="synonym">LOC113834149</name>
        <name evidence="21" type="synonym">LOC113834164</name>
        <name evidence="20" type="synonym">LOC113834352</name>
        <name evidence="13" type="synonym">LOC113834409</name>
        <name evidence="14" type="synonym">LOC113834420</name>
        <name evidence="15" type="synonym">LOC113835009</name>
        <name evidence="16" type="synonym">LOC113835041</name>
        <name evidence="22" type="synonym">LOC113835055</name>
        <name evidence="17" type="synonym">LOC113835330</name>
        <name evidence="23" type="synonym">LOC113835850</name>
        <name evidence="19" type="synonym">LOC113837528</name>
        <name evidence="24" type="synonym">LOC118239448</name>
    </gene>
    <organism evidence="9 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
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                <person name="Goesmann A."/>
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            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027287058.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="70429" checksum="6D2B93B415A9E1D9" modified="2023-06-28" version="1">MPRRSQAPKATAADSPELSEVSWPSSSGTPSPLSTEGQSTSPPLTVIDSGDSVVAKYINRFRQAQPTSREERQPAGATPADFWWLQPKSSDISSNLAAAGAGEPEPEGRSDMTGPSPAQMYSGSLASDPLQNVKQSLNTWNSSLLDLETLSLQSRAAKLLKRSKASLSSSSLSPSDASSSSFPINLDGLSPCSVTFNPNANKNSSPKESVSGEAPGPSQARIPAPRPASSQATLPPEEDILYQWRQRRRLEQARGGAGDGTWVLPRTPAPATQPPPVPAVNLGSLGTQPDGAPPWGSVVQPPPPQAYVERAPPLAGPSPHIWAPSPHGFLWAPQANPWVSLGMVPTTLLAPTVAPLAAFPAPATTSPAAPAPISTPQVTISVPPASTPSPWAPTPTSPAPDIPQEPTNPELSSSAQPKKLGPKPRRARASSPRETSEQGTTAFESPCSQLRGALGQVVTARLFPDSLEDTVVPGLESLSPSQVEPQKVNATPPQAKGPPGPSQAQREAKSLSCKAVAASSRGRPVLRKSKGTLSAETRDPELATTPKAFALSEAQSPEFKTSEPKAGAGDAWTTAPPASGQAPSQDLLAQASRLLQAAEDSDGSEFQEDPVLQVLRAQRAELRQQKRKVDAQLSLLLNHTEDPGSSSPPASSPPGSPRMRLRREGASFEARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GL14</accession>
    <name>A0A9J7GL14_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin target of PRMT1 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113838831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027290147.1">
        <property type="nucleotide sequence ID" value="XM_027434346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GL14"/>
    <dbReference type="GeneID" id="113838831"/>
    <dbReference type="KEGG" id="cge:113838831"/>
    <dbReference type="OrthoDB" id="446014at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052656">
        <property type="entry name" value="CTOP_PRMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48426">
        <property type="entry name" value="CHROMATIN TARGET OF PRMT1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48426:SF1">
        <property type="entry name" value="CHROMATIN TARGET OF PRMT1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027290147.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27045" checksum="D3A90D165C4C32C5" modified="2023-06-28" version="1">MATQSAPKVVLKRNTKVSLNERFTNILKNKQPMPVNMRALMQQQQQQLASARNRRLTLQMENRPSVQALLKLKQSSKQRLGKSNIQARLGRPIGTLAKGAIGGSDLPIIQRGLPRGGLHGAHATRTPLRGRKLLQGQNLLQGGRALATGMDLRRGGVRGRGGPGRVGLGRGAMGHGRICGRVPAMICPGREGFGGRGQCLGRRRGALTRNVLTKEQLDNQLDAYMSKTKAHLDAELDAYMAQTDPETND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMD8</accession>
    <name>A0A9J7GMD8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipocalin Cav p 3.0101-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC103164259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007648854.1">
        <property type="nucleotide sequence ID" value="XM_007650664.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288499.1">
        <property type="nucleotide sequence ID" value="XM_027432698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GMD8"/>
    <dbReference type="GeneID" id="103164259"/>
    <dbReference type="KEGG" id="cge:103164259"/>
    <dbReference type="OrthoDB" id="9632937at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027288499.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18080" checksum="CEF028DB9873B698" modified="2023-06-28" version="1">MAAKEIDMITDYGMLKLFFRHLECIRGCKEMILMFYGEVDEECEKFEIEAKQVFSKEFFCTYAGKHQFRILYVSSSIMVIFDYYLTPDENLIKVLFLVGKGDSVSGEEQQKFAELCDKMRIPKEKIRYMFEKDNDKIKNICNREFSMAIDSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GRE1</accession>
    <name>A0A9J7GRE1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin light chain kinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Mylk3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297298.1">
        <property type="nucleotide sequence ID" value="XM_035441407.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317637.1">
        <property type="nucleotide sequence ID" value="XM_035461746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GRE1"/>
    <dbReference type="GeneID" id="100766446"/>
    <dbReference type="KEGG" id="cge:100766446"/>
    <dbReference type="CTD" id="91807"/>
    <dbReference type="OrthoDB" id="10260894at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004687">
        <property type="term" value="F:myosin light chain kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000196">
        <property type="entry name" value="Myosin light chain kinase family, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000135">
        <property type="entry name" value="Putative myosin light chain kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="503"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035297298.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="88168" checksum="8DE2476CA39E4F8B" modified="2023-06-28" version="1">MSGVSEEDLEGLGPLGLPALGRACLATMDKKLTVLSEKVDRLLHFQDDVTEKLQCVCRGMDHLEQGLHRLEASRELGLAGSDNPPPAAAQGAWPEVLELVRAMRQEGAQHGARLESLFKTVMAVDRAITLVGATFQNSKVDDFIAQGTVPWREGSLVDRPEENKEQAEATGAKPKHVLTAGGAVCFHASYYLAESQKEDIAVGTVERLPLIINPSLKGADFTQGGASVRQGVEVLGPGQVPPPTEAEIRLPEASSENPGTTLELSVALGRISEVFTSLKMSQSAEQGTSSSKPDCWLSEEGMRLSSGPSPLSLGPLTPASEVHSGEAHPRISVQEMDTPRELLETPRGSPMASTDVPAVTQPDEQEPHPKGPGTELEDQIPKGARAFPPLPKRSSNNGGMNAEEEVESRAEPLAGPSLTTRDWGDEAVGTTDLQQDTDSGVGKPEPTKDHAAKSSGGMEAGGRMQPAAEAAVMVLDDSAAPPAPFEHRVVSVKDTSISAGYTVSQHEVLGGGRFGQVHRCMERSTGLALAAKIIKVKNLKDREDVKNEISIMNQLSHVNLIQLYDAFESKNSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTKQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFKGLSEEAKDFVSRLLIKEKSCRMSATQCLKHEWLNHLPAKALGSKVRLRSQLLLQKYMAQSKWKKHFHVVAAVNRLRKFPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GT39</accession>
    <name>A0A9J7GT39_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcitonin gene-related peptide 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC100774487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calcitonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297209.1">
        <property type="nucleotide sequence ID" value="XM_035441318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GT39"/>
    <dbReference type="GeneID" id="100774487"/>
    <dbReference type="KEGG" id="cge:100774487"/>
    <dbReference type="OrthoDB" id="9929923at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031716">
        <property type="term" value="F:calcitonin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021117">
        <property type="entry name" value="Calcitonin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021116">
        <property type="entry name" value="Calcitonin/adrenomedullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018360">
        <property type="entry name" value="Calcitonin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015476">
        <property type="entry name" value="Calcitonin_gene-rel_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001693">
        <property type="entry name" value="Calcitonin_peptide-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10505:SF3">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10505">
        <property type="entry name" value="CALCITONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00214">
        <property type="entry name" value="Calc_CGRP_IAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00817">
        <property type="entry name" value="CALCITONINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00113">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00258">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0027">Amidation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039951193" evidence="7">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Calcitonin peptide-like" evidence="8">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR621116-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035297209.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17100" checksum="B8FFBA0B2EDEB980" modified="2023-06-28" version="1">MGFWKFFPFLALSSVWILCLASSSQAAPFRSALESSLDPATLSEQEKRLLLVALMQNYYEQARKLEQEEQEAEGSSSGSKQLGNDQINTSETMLEPMFLTLASITGQKRSCNTATCVTHRLAGFLSRSGGVAKDNFVPTNVGSNAYGRRRRDLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GVF2</accession>
    <name>A0A9J7GVF2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">17beta-estradiol 17-dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rdh8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid biosynthesis; estrogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.62" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035300257.1">
        <property type="nucleotide sequence ID" value="XM_035444366.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035309939.1">
        <property type="nucleotide sequence ID" value="XM_035454048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GVF2"/>
    <dbReference type="GeneID" id="100773401"/>
    <dbReference type="KEGG" id="cge:100773401"/>
    <dbReference type="CTD" id="50700"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006703">
        <property type="term" value="P:estrogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061370">
        <property type="term" value="P:testosterone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000323">
        <property type="entry name" value="Estradiol 17-beta-dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">17A/GY</strain>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">17A/GY</strain>
        </source>
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        <source>
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    </evidence>
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    <sequence length="90" mass="10669" checksum="6618D1389A92B0B7" modified="2023-06-28" version="1">MRDAVTYEDVHVNFTQEEWALLDPSQKSLYKDVMLETWENLISIGYKWEEQNIEEHWQSSRRHGRFIICHSGCKPSEHKGSGKKQCYPTP</sequence>
</entry>
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    <accession>A0A9J7H074</accession>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">17A/GY</strain>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
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            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    <dbReference type="RefSeq" id="XP_035293056.1">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="TLCD5"/>
    </dbReference>
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        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 136"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035300683.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30641" checksum="FC7750140183D50B" modified="2023-06-28" version="1">MTCCCFLRVHPLFSWFWSFCHRMALGLCLQVLCSLGGWLSLYTSFCRLNKHRSYEWSCRLVTFTHGVLSIGLSAYIGFIDGPWPFTHPGSPNTPLQVHILCLTLGYFIFDLGWCIYFQSEGALMLAHHTLSILGIIMALALGESGTEVNAVLFGSEITNPLLQMRWFLRETGHYHSFTGDVVDFLFVALFTGVRIGVGAHLLFCEMVSPTPKWFVKVGGIAMYAVSWCFMVSIWRFAWKKSIKKYHAWRSRRNEERQPRHNGRLKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H2F6</accession>
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    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:60004"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:60005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295881.1">
        <property type="nucleotide sequence ID" value="XM_035439990.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302857.1">
        <property type="nucleotide sequence ID" value="XM_035446966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H2F6"/>
    <dbReference type="GeneID" id="100761623"/>
    <dbReference type="KEGG" id="cge:100761623"/>
    <dbReference type="CTD" id="79841"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06907">
        <property type="entry name" value="M14_AGBL2-3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3120:FF:000001">
        <property type="entry name" value="cytosolic carboxypeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000011">
        <property type="entry name" value="cytosolic carboxypeptidase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF41">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 24" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="22">
        <location>
            <begin position="361"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="760"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="701"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035302857.1"/>
        </source>
    </evidence>
    <sequence length="867" mass="100240" checksum="0F5F6BFF565ADB7D" modified="2023-06-28" version="1">MFPALETELKQETLPDPYEDFMHHHLQYYGYFKAQKGNLPNSATHQRIWKTSPRYMLNGSFGEKDDLVSDTLDLGKEMFLWPTCLSSTGHTQVDAVNRDSLMLSSPLLRSRQLLYDELDEVNPRLREPRELFSFFSSQGPLQAPRWPIECEVIKENIHHIEWVPPQPEYFYQPTGDEKLPEIVGEEQGTVVYQLDSVPTEGAYFTSSRIGGKRGIIKELAVTLQGPEDNTLLFESRFESGNLQKAVRVGIYEYELTLRTDLYTDKHTQWFYFRVQNTRKEVTYRFTIVNLLKPKSLYAVGMKPLMYSELDATTYNIGWRRAGHEIKYYKNNMEEGQQSLYCLTWTLQFPHDQDTCFFAHFYPYTYTDLQCYLLSIANNPIQSQFCKLRALCRSLAGNTVYLLTITNPSRTPQEAAAKKAVVLSARVHPGESNGSWIMRGFLDFILSNSPDAQLLRDIFVFKVIPMLNPDGVIVGNYRCSLAGRDLNRHYKTVLKDSFPCIWYTKNMIKRLLEEREVLLYCDFHGHSRKNNIFLYGCNSNSRKHWLHERVFPLMLSKNAPDKFCFDSCNFKVQKCKEGTGRVVMWRMGIINSYTMESTFGGSTLGRKRDTHFTIEDLKSLGYHVCDTILDFCDPDQTKYTQCLQELKELLQQEIHKKFNNFGQDMDLEGNWSDIPLSDIESSTSGSDSSLSDGLPAHLLNIADEVNQKMILKKQKKKRLQTRKQRNEQYQKNYLMRELKLTENNTPGRARFASTLQKQPTFLKNPENSSSSIMRNEKPRLNETQLSGRDKGTSLDPPLTSLVLPKNKEIIQSKKPGFTTSCSPKRSTNSSLGPSPDVKPNWPRTRYPATRKDRTTMVVYPSLHIYTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H9K9</accession>
    <name>A0A9J7H9K9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="17">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Erbb3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="17"/>
    <dbReference type="RefSeq" id="XP_035307246.1">
        <property type="nucleotide sequence ID" value="XM_035451355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767681"/>
    <dbReference type="KEGG" id="cge:100767681"/>
    <dbReference type="CTD" id="2065"/>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038132">
        <property type="term" value="F:neuregulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038131">
        <property type="term" value="F:neuregulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038127">
        <property type="term" value="P:ERBB signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
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        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
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        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
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        <property type="entry name" value="GF_recep_IV"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="RTK"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="Tyr_kinase_AS"/>
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        <property type="entry name" value="Tyr_kinase_EGF/ERB/XmrK_rcpt"/>
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        <property type="entry name" value="RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
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        <property type="entry name" value="TYRKINASE"/>
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        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
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    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 17 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 17 25" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="11 17" id="KW-0829">Tyrosine-protein kinase</keyword>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="20"/>
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        </location>
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            <begin position="713"/>
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        <location>
            <begin position="778"/>
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        <location>
            <begin position="21"/>
            <end position="46"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1104"/>
            <end position="1123"/>
        </location>
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        <location>
            <begin position="1149"/>
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        <location>
            <begin position="1110"/>
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        </location>
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        <location>
            <begin position="1236"/>
            <end position="1256"/>
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        <location>
            <begin position="1257"/>
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        <location>
            <begin position="784"/>
            <end position="792"/>
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        <ligand>
            <name>ATP</name>
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        <location>
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        </location>
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            <dbReference type="ARBA" id="ARBA00058769"/>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HAF8</accession>
    <name>A0A9J7HAF8_CRIGR</name>
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        <name evidence="4" type="primary">Sdr39u1</name>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035308281.1">
        <property type="nucleotide sequence ID" value="XM_035452390.1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092:SF0">
        <property type="entry name" value="EPIMERASE FAMILY PROTEIN SDR39U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092">
        <property type="entry name" value="SUGAR NUCLEOTIDE EPIMERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1731"/>
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    </dbReference>
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        <property type="entry name" value="Epimerase"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="2">
        <location>
            <begin position="271"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035308281.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="34511" checksum="715930BA1514801C" modified="2023-06-28" version="1">MRVLVGGGTGFIGTALTQLLKARGHEVTWVSRQPGPGRTTWVRPASARWVGGQFGREGQFFLCFLPQSELSRSGLPLCDVVINLAGENVLNPRRRWNEAFQKEVLTSRLDTTHLLAKAITKAEHPPRAWILVTGVAYYKPSPTEEYDEDSPGGNFDFFSNLVTKWEEAARLPGESTRQVVVRSGVVLGRGGGAIGQMLLPFRLGLGGPIGSGHQFFPWIHIGDLAGILIHALEANHVQGVLNGVAPASTTTNAEFAQALGAALGRPAFIPVPSIVVQAVFGRERATMLLEGQKVVPRRTLATGYQYSFPELGAALKDIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J692</accession>
    <name>A0A9J7J692_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: transcription factor SOX-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC113832352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027243533.1">
        <property type="nucleotide sequence ID" value="XM_027387732.2"/>
    </dbReference>
    <dbReference type="GeneID" id="113832352"/>
    <dbReference type="KEGG" id="cge:113832352"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF328">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027243533.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="38993" checksum="0FA0E746390CBDAF" modified="2023-06-28" version="1">MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGXGTKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVGVGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGIPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSRAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JBT5</accession>
    <name>A0A9J7JBT5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gamma-crystallin E isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100757295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003499339.1">
        <property type="nucleotide sequence ID" value="XM_003499291.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251864.1">
        <property type="nucleotide sequence ID" value="XM_027396063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JBT5"/>
    <dbReference type="GeneID" id="100757295"/>
    <dbReference type="KEGG" id="cge:100757295"/>
    <dbReference type="OMA" id="RFHFQEM"/>
    <dbReference type="OrthoDB" id="8407241at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000001">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF125">
        <property type="entry name" value="GAMMA-CRYSTALLIN E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027251864.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="21146" checksum="34DDAD1C8617C414" modified="2023-06-28" version="1">MGKITFYEDRGFQGRHYECSSDHSNLQPYFSRCNSVRVDSGCWMLYEQPNFAGCQYFLRRGDYPDYQQWMGLSDSVRSCRLIPHSSSHRIRIYEREDYRGQMVETTDDCSHLQDRFHFSDFHSFHVLEGYWVLYEMPNYRGRQYLLRPGEYRRYHDWGAMNARVGSLRRIMDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JP47</accession>
    <name>A0A9J7JP47_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100768112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269054.1">
        <property type="nucleotide sequence ID" value="XM_027413253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JP47"/>
    <dbReference type="GeneID" id="100768112"/>
    <dbReference type="KEGG" id="cge:100768112"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="199"/>
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        <location>
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            <begin position="43"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027269054.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36615" checksum="8CB7C64948E6AFBE" modified="2023-06-28" version="1">MRMEKVNHSLTIEFILVGFSDHPDLKTLLFLVFFVIYLVTMVGNLGLVVLIYMERRLHTPMYIFLGNLALMDSCCSCAITPKMLQNFFSVDRRISLYECMAQFYFLCLAETADCFLLAAMAYDRYVAICNPLQYHTMMSKKLSIQMSIATFIASNVHSMIHVGCLLRLTFCKSNRIDHFFCDILPLYRLSCTDPFINELMIYIFSMPIQVFTITTVLVSYFCILFTIFKMKSKDGRGKAFSTCGSHFLSVSIFYICLLMYIRPFEEGNKDIPVAVFYTIIIPLLNPFIYSLRNKEVFNAVKKIASTYCTFKKSASTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JRB5</accession>
    <name>A0A9J7JRB5_CRIGR</name>
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        <submittedName>
            <fullName evidence="10">T-box transcription factor TBX19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Tbx19</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_003502281.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273897.1">
        <property type="nucleotide sequence ID" value="XM_027418096.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JRB5"/>
    <dbReference type="GeneID" id="100766401"/>
    <dbReference type="KEGG" id="cge:100766401"/>
    <dbReference type="CTD" id="9095"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20201">
        <property type="entry name" value="T-box_TBX19-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000002">
        <property type="entry name" value="T-box transcription factor Brachyury"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF114">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="45"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027273897.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="48373" checksum="3B96729979C805F3" modified="2023-06-28" version="1">MAMSELGTQKAGEGTVSRLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGGAHRMVMNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLKDIPEAVSESQHVTYSHLGGWIFSNPDGMCAAGNTSYQYATPLPLSAPHTHHGCEHYPGLRGHRQAPYPSAYMHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLWTISDGGGGPVASSSEVHVSTPGTFLLGNPAVTSPSSVLPTQATTSASVEVLGEPSLTSIAVSTWTAVASRPFPGWGGPGGGGRHSPSSLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JTG5</accession>
    <name>A0A9J7JTG5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUT family member 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC100773844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289801.1">
        <property type="nucleotide sequence ID" value="XM_027434000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JTG5"/>
    <dbReference type="GeneID" id="100773844"/>
    <dbReference type="KEGG" id="cge:100773844"/>
    <dbReference type="OrthoDB" id="9634453at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024310">
        <property type="entry name" value="NUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024309">
        <property type="entry name" value="NUT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22879">
        <property type="entry name" value="NUT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22879:SF14">
        <property type="entry name" value="NUT FAMILY MEMBER 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12881">
        <property type="entry name" value="NUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear Testis protein N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027289801.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="85195" checksum="0AEFE1329163177C" modified="2023-06-28" version="1">MDPSKQAWLLSKPVGITSEASSLGQNMTVNLDAAMSTFATLPVLPPAPQPTLQLFWEPQEPLLTGGISPWNPLVLSALPGMSLVAEDGSTTLGTAVPLNIVQIGTTGRPVQPMPNANLFLTQVSLNCNVPVTQGGVIGCPASDFMTTHEANTFINAQIASAFQNQEVLWVLGSHPPTTQPVVQLVPVQSPVNSAPPPKGAVVESGPANVQTNSTENCLSKPDSVYGNIRRWQHIKTLVQRHLSQTPDVSAFSCFLIPVLRSLAQRKPTMNVEEGLWRGLQEWQCTSNYDRMIFFEMAEKFKEFENAEEKENSRLEFENSRLEMTRSIKCQVLTTTRQDPPRFPAPEVFEEPVCNSMKIGSITDPACLPVFRHRQLQKTEATMEIPPEAMQEYMDITDWLERPPQSNTGNPTEKEQEENSEPEQEEDDFYSDAGVLSYIDELCSQKHFVDQVEDIIHPQFVAEILSSKPEIDILSLMKDLEYEEEFSVEQLVEENCMALKKKGCKRATLKPGAPQILSNASFPTVCQDAKREGHGPQRGTSAQKRSSLVPSLDHQFPGATNAEIWGPSPTVFQSSQCLPSLGDLSSTVITYGRGAHPQSPGSRCAMSLRGVSAMEEFQEALGRTIEDKEEIPSLSFLLCSHYSLVPWKLSGYLCPYTGLSDSASIPKPLSPRMRDLSPDPSSNDKSNKPALIGGLTPMAKRSNSGLGHGIFEGPLSALGLTHSLQAQKFDSLSTRKRKRKKWHCVTCGMSRQSRQSFTLPPPCTPIPKMKKKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUB1</accession>
    <name>A0A9J7JUB1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Arginine-glutamic acid dipeptide repeats protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">Rere</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22">17A/GY</strain>
            <tissue evidence="21 22">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035295280.1">
        <property type="nucleotide sequence ID" value="XM_035439389.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295281.1">
        <property type="nucleotide sequence ID" value="XM_035439390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770191"/>
    <dbReference type="KEGG" id="cge:100770191"/>
    <dbReference type="CTD" id="473"/>
    <dbReference type="OrthoDB" id="6147534at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04709">
        <property type="entry name" value="BAH_MTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000052">
        <property type="entry name" value="Arginine-glutamic acid dipeptide (RE) repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000003">
        <property type="entry name" value="Arginine-glutamic acid dipeptide (RE) repeats a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017993">
        <property type="entry name" value="Atrophin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002951">
        <property type="entry name" value="Atrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF12">
        <property type="entry name" value="ARGININE-GLUTAMIC ACID DIPEPTIDE REPEATS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03154">
        <property type="entry name" value="Atrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01222">
        <property type="entry name" value="ATROPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="17">
        <location>
            <begin position="103"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="18">
        <location>
            <begin position="284"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="19">
        <location>
            <begin position="391"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="542"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1154"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="807"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="902"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="962"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1045"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1098"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1154"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035295280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035295281.1"/>
        </source>
    </evidence>
    <sequence length="1566" mass="172431" checksum="3C12BDAD9B162F9E" modified="2023-06-28" version="1">MTADKDKDKDKEKDRDRDRDREREKRDKARESENARPRRSCTLEGGAKNYAESDHSEDEDNDNNSATTEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHSSQACCRSPAPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTPHEELVWMPGVSDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESSYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSEGQMSTLRSGRKKQPASPDGRASPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKAKEEAASPLKSTKRQREKVASDTEEPDRTTSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQTLQAQPPSLQAPSGAASAPSAPPGAPQLSTPGPTPSATAVPPQGSPATSQPPNQTQPAVAAAHTHIQQAPSLHPPRLPSPHPPLQPLTAPPSQNSTQPHTQPSLHGQGPPGPHSLQAGSLLQHPGPPQPFGLPPQASQGQGPLGSSPAAHPHSTIQLPASQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPASSHPPTGLHQVPSQSPFPQHTFVPGGPPPITPPACPSTSTPPAGPSASSQPPCPAAVSSGGSVPGAPSCPLPAVQIKEEALDEAEEPESPPPPPRSPSPEPTIVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHSALTIPPAAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTGDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFAERVLCLAGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUE4</accession>
    <name>A0A9J7JUE4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 18">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Ssrp1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with MYOG (via C-terminal region). Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also a component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Binds to histone H3-H4 tetramers, but not to intact nucleosomes. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts with isoform gamma of TP63. Interacts with FYTTD1/UIF. Interacts with SRF. Interacts with NEK9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027278443.1">
        <property type="nucleotide sequence ID" value="XM_027422642.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JUE4"/>
    <dbReference type="GeneID" id="100758773"/>
    <dbReference type="KEGG" id="cge:100758773"/>
    <dbReference type="CTD" id="6749"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21994">
        <property type="entry name" value="HMG-box_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000032">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000001">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000098">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000119">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048985">
        <property type="entry name" value="SSRP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21092">
        <property type="entry name" value="SSRP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 18" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 18" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15 17 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-0804">Transcription</keyword>
    <keyword evidence="11 18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="HMG box" evidence="20">
        <location>
            <begin position="547"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="17">
        <location>
            <begin position="547"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="458"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="577"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027278443.1"/>
        </source>
    </evidence>
    <sequence length="709" mass="81053" checksum="BB7C0362B6879AFC" modified="2023-06-28" version="1">MAETLEFNDIFQEVKGSMNDGRLRLSRQGIIFKNSKTGKVDNIQAGELTEGIWRRVALGHGLKLLTKNGHVYKYDGFRESEFEKLSDFFKTHYRLELMEKDLCVKGWNWGTVKFGGQLLSFDIGDQPVFEIPLSNVSQCTTGKNEVTLEFHQNDDAEVSLMEVRFYVPPTQEDGVDPVEAFAQNVLSKADVIQATGDAICIFRELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQMFFVISLDPPIKQGQTRYHFLILLFSKDEDISLTLNMNEEEVEKRFEGRLTKNMSGSLYEMVSRVMKALVNRKITVPGNFQGHSGAQCITCSYKASSGLLYPLERGFIYVHKPPVHIRFDEISFVNFARGTTTTRSFDFEIETKQGTQYTFSSIEREEYGKLFDFVNAKKLNIKNRGLKEGMNPSYDDYADSDEDQHDAYLERMKEEGKIREENANDSSDDSGEETDESFNPGEEEDDVAEEFDSNASASSSSNEGDSDREEKKRKQLKRAKMAKDRKSRKKSSEAKKGKDPNAPKRPMSAYMLWLNASREKIKSDHPGISITDLSKKAGEIWKGMSKEKKEEWDRKAEDARREYEKAMKEYEGGRGESSKRDKSKKKKKVKAKMEKKSTPSRSSSSKSSSRQLSESFKSKEFVSSDESSSGENKSKKKRRRSEDSEEEELASTPPSSEDSASGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K0I4</accession>
    <name>A0A9J7K0I4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="12 16">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Mogs</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="function">
        <text evidence="14">In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:55989"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="12 16"/>
    <dbReference type="RefSeq" id="XP_027285197.1">
        <property type="nucleotide sequence ID" value="XM_027429396.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100689098"/>
    <dbReference type="KEGG" id="cge:100689098"/>
    <dbReference type="CTD" id="7841"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000009">
        <property type="entry name" value="mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000001">
        <property type="entry name" value="Mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="20">
        <location>
            <begin position="92"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="19">
        <location>
            <begin position="350"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027285197.1"/>
        </source>
    </evidence>
    <sequence length="834" mass="92207" checksum="2F43233EFD8B1374" modified="2023-06-28" version="1">MARGERRRRSAAAEGARPLDRXRGAGRRDGRASGARGXAGGAALAVVVLALAFGLSGRWVISWLRVRRALTLHPAPPALPPDSSSPAVAPELFWGTYRPHVYFGMKTRSPKPLLTGLMWAQQGATPGTPPKLRHTCEQGDGVGPYGWEFHDGLSFGRQHISDGALRLTTEFVKRPGGQHGGDWSWRVTVEPQASGTSSLPLVSLFFYVVTDGQEVLLPEVGAKGQLKFISGHTSELGDFRLTLLPPTSPGDTVPKHGSYNVFWSSNPGLPLLTDMVKNHLNSWFQHRPPGASPERYLGLPGSLKWEERGPSGQGQFLIQQVTLKVPFSVEFIFESGSAQAGRNKALGQLVGSQLTQALENHAAAFQERFERTFQLKEKGLSPEEQALGQVALSGLLGGIGYFYGQGLVLPDTGVEGSEQKVDPALFPPVPLFSGVPSRSFFPRGFLWDEGFHQLVVQRWDPHLTREALGHWLGLLNADGWIGREQILGDEARSRVPPEFLVQRVAHANPPTLLLPVLQMLEGGDPDDLAFLRKAFPRLHAWFSWLHQSQAGPVPLSYRWRGRDQALPTLLNPKTLPSGLDDYPRASHPSTSERHLDLRCWVALGARVLSQLAEQLGEAEAAAELGPLAASLEEPRNLDELHWAPELGVFADFGNHTKAVQLKSRPPQGLVRVVGRPPPQLQYVDALGYISLFPFLLQLLEPQSPRLGPLLNVLADSRHLWSPFGLRSLSASSLFYRQRNSEHDPPYWRGAVWLNINYLALGALHHYGHVEGPYKVQATKLYHELRANVVSNVWRQYQTTGFLWEQYSDQDGRGMGCRPFHGWTSLVLLIMAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3W3</accession>
    <name>A0A9J7K3W3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Hey1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="9">Belongs to the HEY family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="107"/>
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        <location>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
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            <authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035298954.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="18986" checksum="FC210174DD005A4A" modified="2023-06-28" version="1">MTLASVLQLPMPVNQHGFFGLGGRADLLDLGPGSPGDGLNLAAPSWGVPEEPRIEMLHGTTTLAFKFRHVAADSRATAGAYIASQTVKKVIEINPYLLGTVAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQSKGKGLSMGTMIVSGLREALRDECLTALPSPTS</sequence>
</entry>
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        <submittedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 58-like</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="primary">LOC118238447</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035297179.1">
        <property type="nucleotide sequence ID" value="XM_035441288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K5W1"/>
    <dbReference type="GeneID" id="118238447"/>
    <dbReference type="KEGG" id="cge:118238447"/>
    <dbReference type="OrthoDB" id="264785at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF31">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035297179.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17052" checksum="9E6E68B9B2D7F994" modified="2023-06-28" version="1">MGWDHIPKEDGFSFSQPPHIASSNLKEKEKLYVELKHVLARQPGPEAAEQLQIYRHTLRERTKQLKVLSSELNMYESQSQEYKYEIERLGNELVALKKKYLAQKRKELVQKNKERVSMNSIFSESKNSGPRFTGGGFPLTQTTKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K8D0</accession>
    <name>A0A9J7K8D0_CRIGR</name>
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        <submittedName>
            <fullName evidence="5">Schlafen family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Slfn5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035303961.1">
        <property type="nucleotide sequence ID" value="XM_035448070.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312533.1">
        <property type="nucleotide sequence ID" value="XM_035456642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K8D0"/>
    <dbReference type="GeneID" id="100750338"/>
    <dbReference type="KEGG" id="cge:100750338"/>
    <dbReference type="CTD" id="162394"/>
    <dbReference type="OrthoDB" id="6052143at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="entry name" value="Schlafen, AAA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031450">
        <property type="entry name" value="Poxin-SLFN/SLFN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029684">
        <property type="entry name" value="Schlafen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
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    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048729">
        <property type="entry name" value="SLFN_GTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155">
        <property type="entry name" value="SCHLAFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155:SF26">
        <property type="entry name" value="SCHLAFEN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17057">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="SLFN_AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21026">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poxin-Schlafen/Schlafen-like N-terminal" evidence="2">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Schlafen AlbA-2" evidence="1">
        <location>
            <begin position="188"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Schlafen GTPase-like" evidence="3">
        <location>
            <begin position="381"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035303961.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="100999" checksum="93D63766E5A9C4AF" modified="2023-06-28" version="1">MSILANLELNFAECILDGGKATLGVRQRAGMDPAHRMRQDEAISQAVCALLNSGGGVVRVEIENEDYNYESDGVGLDLPPLFRNHIDEMLQGKLFLIFVNSWEVAPSGVQLATLCSNLYHRRGTFTEVMDSLEALLFLRRRIQALENVDDPSSLNPQEAPVDNQMILAADLFGKQQQLLYLEKLNFTESPHVEFQMFSVDLTQGIKEKLPKCVSALANSEGGYVFFGVHDETCQVIGCEKEKVNHSSLLNVIDRCIRSMPVHHFCSQVHKVQHDCKFLEVYDKGAVRGYVCVIKVEQFCCAAFSRAPDSWEMKDNQMKQLATKDWAAWMIKTDTELSRFPQMIISRSVTDTTPRCRTVCIHKNLKCVEELQKDFFPVSPDRITYTPESVYRDLFSDHRGLRNLISMEMRSFSQGVLIFSHSWAVDLGLQRRRGVICDALLISPNNVPILYTICNKWDLGYRWYAMTVARTLKQRLANMGGYPGRLGIIPLVLQLGPHHTVRAGLEIPIYPESYNFTTMQQMEVLLQSLVIVLFGFRSFLNEELNSEAVTLFTDQQYQLLLKDLCKNRELFVHGSPGSGKTTLALKIMEKIRNVFSCQAEDILYICENHALKRFVSQRNICQAVSRKYFMKNTFFTIKHIVVDDAQNFRTEDGNWYAKANSIIQRGRDGPGVLCVFLDYFQTNHLCCSGLPDLQHQRFILKLTRMLRSGDNIANYLQEIMQQIRRNPPPNVPSEALTMVQELERVPGVTGNLEITDALSLEQMAIFVAEKCRYLWRSGYYPRDVAVLFSKARDIETYKEKIILALRRRNMSQLIEEPSSLMQVREESEFLGNNILLTSVQQFSGMERSVVFGIIPAEFETAIFYNVLLCLASRARTHLYIIKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K8F7</accession>
    <name>A0A9J7K8F7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cleavage and polyadenylation specificity factor subunit 4</fullName>
            <shortName evidence="8">CPSF 30 kDa subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cleavage and polyadenylation specificity factor 30 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Cpsf4l</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the cleavage and polyadenylation specificity factor (CPSF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304056.1">
        <property type="nucleotide sequence ID" value="XM_035448165.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311954.1">
        <property type="nucleotide sequence ID" value="XM_035456063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K8F7"/>
    <dbReference type="GeneID" id="100762278"/>
    <dbReference type="KEGG" id="cge:100762278"/>
    <dbReference type="CTD" id="642843"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF19">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035304056.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21723" checksum="931ED2FF2CEF3458" modified="2023-06-28" version="1">MEEVIAALEGVTFAFEQDVELQKGTGLLPFQGMDKSNSAVCNFFAKGLCEKGTLCPLRHEKGEKIVVCKHWLRGLCRKGDCCNFLHQYDIDRMPVCYFHSKFGNCSNKDCSFLHVKPAPNAQDCPWYDRGFCKDGPLCKYHHVHQVMCLNYFTGFCPKGPKCQFGHPKMSQVLHPSNVKKAHALRPGHLSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KB20</accession>
    <name>A0A9J7KB20_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Paired box protein Pax-8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Pax8</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with WWTR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035302968.1">
        <property type="nucleotide sequence ID" value="XM_035447077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KB20"/>
    <dbReference type="GeneID" id="100758326"/>
    <dbReference type="KEGG" id="cge:100758326"/>
    <dbReference type="CTD" id="7849"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Paired box 8 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022130">
        <property type="entry name" value="Pax2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF6">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12403">
        <property type="entry name" value="Pax2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="12">
        <location>
            <begin position="48"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035302968.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="52942" checksum="B4868CF3D8F33BF2" modified="2023-06-28" version="1">MASEGSEEQVQEQMWGGAYTIVPAFPGVSPNTYHLVLTIVPDNPVFLGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDNKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLDCPFERQHYSEAYASPSHTKGEQGLYPLPLLNSALDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPELSSSSSTPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYSHTPYSSYSEAWRFPNSSLLSSPYYYSSTTRPSAPPTSATAFDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KEY7</accession>
    <name>A0A9J7KEY7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-3 adrenergic receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-3 adrenoreceptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Adrb3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ARRDC3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301634.1">
        <property type="nucleotide sequence ID" value="XM_035445743.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308126.1">
        <property type="nucleotide sequence ID" value="XM_035452235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KEY7"/>
    <dbReference type="GeneID" id="100775030"/>
    <dbReference type="KEGG" id="cge:100775030"/>
    <dbReference type="CTD" id="155"/>
    <dbReference type="OrthoDB" id="5983033at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015052">
        <property type="term" value="F:beta3-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051379">
        <property type="term" value="F:epinephrine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002025">
        <property type="term" value="P:norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000681">
        <property type="entry name" value="ADRB3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BETA-3 ADRENERGIC RECEPTOR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01103">
        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00563">
        <property type="entry name" value="ADRENRGCB3AR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="71"/>
            <end position="89"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="109"/>
            <end position="130"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="151"/>
            <end position="171"/>
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            <begin position="208"/>
            <end position="228"/>
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            <begin position="291"/>
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        <location>
            <begin position="323"/>
            <end position="344"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="51"/>
            <end position="343"/>
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    </feature>
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        <location>
            <begin position="244"/>
            <end position="271"/>
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    </feature>
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        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="262"/>
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    </feature>
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        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011154"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021558"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00030352"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035308126.1"/>
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    </evidence>
    <sequence length="393" mass="42259" checksum="3B8FE474FBE2E7DC" modified="2023-06-28" version="1">MAPWPHKNSSLALWSDAPTLDPSAANTSGLPGVPWAAALAGTLLAMATVGGNLLVIVAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYSTLVTKRRARAAVVLVWIVSAAVSFAPIMSQWWRVGADAEAQECHSDPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPQTLSRSPSPVTGGTSPAPDGVPSCGRRQARLLPLREHRALRTLGLIMGIFTLCWLPFFLANVLRALAGPSLVPSGFFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSCGGRGREEARAVTFPASPAGATSAESRQSPPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3GRK9</accession>
    <name>G3GRK9_CRIGR</name>
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        <submittedName>
            <fullName evidence="7 11 12">DNA-binding protein RFX7</fullName>
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        <submittedName>
            <fullName evidence="8">Regulatory factor X, 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11 12" type="primary">Rfx7</name>
        <name evidence="7" type="ORF">I79_000158</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11 12">17A/GY</strain>
            <tissue evidence="11 12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RFX family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000003">
        <property type="protein sequence ID" value="EGV99885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003495029.5"/>
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    <dbReference type="RefSeq" id="XP_027266986.1">
        <property type="nucleotide sequence ID" value="XM_027411185.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266987.1">
        <property type="nucleotide sequence ID" value="XM_027411186.2"/>
    </dbReference>
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    <dbReference type="GlyGen" id="G3GRK9">
        <property type="glycosylation" value="8 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007621951.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013827.1">
        <property type="protein sequence ID" value="ENSCGRP00001009608.1"/>
        <property type="gene ID" value="ENSCGRG00001011679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769524"/>
    <dbReference type="KEGG" id="cge:100769524"/>
    <dbReference type="CTD" id="64864"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244970"/>
    <dbReference type="OMA" id="QCQENPD"/>
    <dbReference type="OrthoDB" id="10069709at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000128">
        <property type="entry name" value="DNA-binding protein RFX5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF2">
        <property type="entry name" value="DNA-BINDING PROTEIN RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18326">
        <property type="entry name" value="RFX5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="480"/>
            <end position="586"/>
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            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="688"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="917"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="971"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV99885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027266986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027266987.1"/>
        </source>
    </evidence>
    <sequence length="1459" mass="157379" checksum="50B5D65079BD75FE" modified="2011-11-16" version="1">MAEEQQQPPPQQPDAHQQLPLSAPNPGVALPALVPGLPGTEANALQHKIKNSICKTVQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSSAEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGVEPSAQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELAHFLVKSHYIGTKSMAALTVMAAAPAGLKGIPQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGDASAKKTEGTTANGVSNLPNGNPAILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSPDGKVLPLNVQVVTQHMQSVKQTPKTPQNVPASPGGDRSARHRYPQILPKPANSSALTIRSPTTVLFTSSPIKTAVVPASHVSSLNVVKMTTISLTPSNNNAPLKQSASASSASGTTEESKSIPQIKNGSVVSLQSPGSRASNAGGTSAVEVKMEPEGSSDEHPLQCQENSEESKAPLTTPSALWGQKSNTDGAVPKPSNEGVIEVKATKVCDQRTKCKSRCNEILPGIPAGNNQSTVTLSVATQNLPFTSTSSPSNGDSVNKDSKLCTKSPRKRLSATLQESQVPPVKKPIVEQLSAVTIEGQKPGTVKKDQKVPHSGKTESSTAGAQIPNKVSISVSSHILEDQPLNPTLVASESVLEQQTTPSSSPDVKVKLEGSVFLLDHESKSDGSFNPSEWQQVTKDSDFIAASCEQQQDVSVMTIPEHSDIHDLEKSVWELEGMPQDTYSQQLHSRIPESSLNQIQAQSSDQLPLQSELKEFESSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMSLQSQSVTPGAPMSSHASSAHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYGGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNTNKQEGFAVPAPLDNKGTNSSASNTFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQTNSKKITNVLLSKLDSDNDDAVRGLGMNNMPSNYTARMNLTQILETSPVFPSANSQNMIDSSTSVYEFQTPSYLTKSNSTDQISFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDNLQTSQQLGGQVASDLTNTASDFPSDIRLSTDLSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSESMNSMTSSGFEWIESKDQPTVEMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3GVM9</accession>
    <name>G3GVM9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 9">Calcium-regulated heat-stable protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9 10" type="primary">Carhsp1</name>
        <name evidence="5" type="ORF">I79_001773</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9 10">17A/GY</strain>
            <tissue evidence="9 10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH000041">
        <property type="protein sequence ID" value="EGV96897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003496424.1">
        <property type="nucleotide sequence ID" value="XM_003496376.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007647781.1">
        <property type="nucleotide sequence ID" value="XM_007649591.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279725.1">
        <property type="nucleotide sequence ID" value="XM_027423924.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279726.1">
        <property type="nucleotide sequence ID" value="XM_027423925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GVM9"/>
    <dbReference type="SMR" id="G3GVM9"/>
    <dbReference type="STRING" id="10029.G3GVM9"/>
    <dbReference type="PaxDb" id="10029-XP_007636480.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008486.1">
        <property type="protein sequence ID" value="ENSCGRP00001005507.1"/>
        <property type="gene ID" value="ENSCGRG00001007246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764910"/>
    <dbReference type="KEGG" id="cge:100764910"/>
    <dbReference type="CTD" id="23589"/>
    <dbReference type="eggNOG" id="KOG3070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000022"/>
    <dbReference type="OMA" id="YRGVCKC"/>
    <dbReference type="OrthoDB" id="448492at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000086">
        <property type="entry name" value="Cold shock domain-containing protein C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052069">
        <property type="entry name" value="Ca-reg_mRNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962">
        <property type="entry name" value="CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962:SF3">
        <property type="entry name" value="CALCIUM-REGULATED HEAT-STABLE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CSD" evidence="4">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV96897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027279725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027279726.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15975" checksum="1481DB92CD79AC86" modified="2011-11-16" version="1">MSSEPPPPPPQPPTHQSSVGLLDTPRARDRSPSPLRGNVVPSPLPTRRTRTFSATVRASQGPVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPVEGDEVTYKMCSIPPKNEKLQAVEVVITHLAPGTKHETWSGHVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3GZF3</accession>
    <name>G3GZF3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 23 24 25" type="primary">Mgat5</name>
        <name evidence="19" type="ORF">I79_003217</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23 24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23 24">17A/GY</strain>
            <tissue evidence="22 23 24">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="5"/>
    <dbReference type="EMBL" id="JH000077">
        <property type="protein sequence ID" value="EGW02387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007613026.1">
        <property type="nucleotide sequence ID" value="XM_007614836.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016822211.1">
        <property type="nucleotide sequence ID" value="XM_016966722.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016822214.1">
        <property type="nucleotide sequence ID" value="XM_016966725.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016822216.1">
        <property type="nucleotide sequence ID" value="XM_016966727.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273569.1">
        <property type="nucleotide sequence ID" value="XM_027417768.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273570.1">
        <property type="nucleotide sequence ID" value="XM_027417769.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273571.1">
        <property type="nucleotide sequence ID" value="XM_027417770.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273572.1">
        <property type="nucleotide sequence ID" value="XM_027417771.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GZF3"/>
    <dbReference type="SMR" id="G3GZF3"/>
    <dbReference type="STRING" id="10029.G3GZF3"/>
    <dbReference type="CAZy" id="GT18">
        <property type="family name" value="Glycosyltransferase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="100760162"/>
    <dbReference type="KEGG" id="cge:100760162"/>
    <dbReference type="CTD" id="4249"/>
    <dbReference type="InParanoid" id="G3GZF3"/>
    <dbReference type="OMA" id="HCESKLK"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904894">
        <property type="term" value="P:positive regulation of receptor signaling pathway via STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027833">
        <property type="entry name" value="MGT5A-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15027">
        <property type="entry name" value="MGT5A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MGT5A-like N-terminal" evidence="18">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="17">
        <location>
            <begin position="171"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF15027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGW02387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027273569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027273570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027273571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027273572.1"/>
        </source>
    </evidence>
    <sequence length="740" mass="84561" checksum="DFAFCFBA7C172AE2" modified="2011-11-16" version="1">MAFFTPWKLSSQKLGFFLVTFGFIWGMMLLHFTIQQRTQPESSSMLREQILDLSKRYIKALAEENRNVVDGPYAGVMTAYDLKKTLAVLLDNILQRIGKLESKVDNLVNGTGANSTNSTTAVPSLVSLEKISVADIINGVQEKCVLPPMDGYPHCEGKIKWMKDMWRSDPCYADYGVDGTSCSFFIYLSEVENWCPRLPWRAKNPYEEADHNSLAEIRTDFNILYSMMKKHEEFRWMRLRIRRMADAWIQAIKSLAEKQNLEKRKRKKILVHLGLLTKESGFKIAETAFSGGPLGELVQWSDLITSLYLLGHDIRISASLAELKEIMKKVVGNRSGCPTVGDRIVELIYIDIVGLAQFKKTLGPSWVHYQCMLRVLDSFGTEPEFNHASYAQSKGHKTPWGKWNLNPQQFYTMFPHTPDNSFLGFVVEQHLNSSDIHHINEIKRQNQSLVYGKVDSFWKNKKIYLDIIHTYMEVHATVYGSSTKNIPSYVKNHGILSGRDLQFLLRETKLFVGLGFPYEGPAPLEAIANGCAFLNPKFSPPKSSKNTDFFIGKPTLRELTSQHPYAEVFIGRPHVWTVDLNNREEVEDAVKAILNQKIEPYMPYEFTCEGMLQRINAFIEKQDFCHGQVMWPPLSALQVKLAEPGQSCKQVCQENQLICEPSFFQHLNKEKDLLKYRVTCQSSELYKDILVPSFYPKSKHCVLQGDLLLFSCAGAHPTHQRICPCRDFIKGQVALCKDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G3H2L5</accession>
    <name>G3H2L5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TNF receptor-associated factor</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Traf5</name>
        <name evidence="19" type="ORF">I79_004430</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TNF receptor-associated factor family. A subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSCGRP00001025090.1"/>
        <property type="gene ID" value="ENSCGRG00001022795.1"/>
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    <dbReference type="KEGG" id="cge:100760758"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:CD40 receptor complex"/>
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        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:apoptotic process"/>
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        <property type="term" value="P:mRNA stabilization"/>
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        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
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        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="term" value="P:regulation of apoptotic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
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        <property type="entry name" value="mRING-HC-C3HC3D_TRAF5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TNF receptor-associated factor"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="MATH/TRAF_dom"/>
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        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
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        <property type="entry name" value="TRAF-like"/>
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        <property type="entry name" value="TRAF1-6_MATH_dom"/>
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        <property type="entry name" value="TRAF3/5_RING"/>
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        <property type="entry name" value="TRAF5_C3HC3D_RING-HC_finger"/>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
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    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 13 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="18">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="18">
        <location>
            <begin position="183"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="403"/>
            <end position="550"/>
        </location>
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        <location>
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        </location>
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    <feature type="zinc finger region" description="TRAF-type" evidence="14">
        <location>
            <begin position="183"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00057263"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGW02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027272332.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="64116" checksum="2F4E67E2137F6BAB" modified="2011-11-16" version="1">MAQSEEQGAVPCSFIRQNSGNSISLDFEPDTEYQFVEQLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRERNTVPICPVDKEAIKPQEVFKDNCCKREVLNLYVYCKNAPGCNARVILGRFQDHLQHCSFQAVPCPNESCREAMLRKDLKEHLSAYCQFREERCLYCKRDVVVTDLQDHEENLCPAYPVSCPNKCLRTIPRTEVNEHLAVCPEAEQDCPFQHYGCTVKGKRGNLQEHEQAALRDHMLLVLEKNFQLEQQISDLYQSLEQKESKIQQLADTVKKFEKEFKQFTQMFGRNGSFLANVQALTSHIDKSAWLEAQVRQLLQIVNQQQNRFDLHSLVEAIDSVKQKVTLLEASDQRLVVLEGETSKHDAHINIHKAQLNKNEERFKLLEGACYSGKLIWKVTDYKAKKRKAVEGHVVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVETFKADPNSSSFRRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLFLKVAVDLTDLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G3HC68</accession>
    <name>G3HC68_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHC-transforming protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Src homology 2 domain-containing-transforming protein C1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Shc1</name>
        <name evidence="11" type="ORF">I79_008018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000275">
        <property type="protein sequence ID" value="EGV98104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003501596.5"/>
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    <dbReference type="RefSeq" id="XP_027249042.1">
        <property type="nucleotide sequence ID" value="XM_027393241.2"/>
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    <dbReference type="STRING" id="10029.G3HC68"/>
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    <dbReference type="KEGG" id="cge:100758936"/>
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    <dbReference type="eggNOG" id="KOG3697">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="G3HC68"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:receptor tyrosine kinase binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:insulin receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SHC-transforming protein 1 isoform 3"/>
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        <property type="entry name" value="SHC-transforming protein 1 isoform 3"/>
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        <property type="entry name" value="CEP152/SHC-Transforming"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR006019">
        <property type="entry name" value="PID_Shc-like"/>
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    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
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    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
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    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035676">
        <property type="entry name" value="SHC_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337">
        <property type="entry name" value="SHC TRANSFORMING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHC-TRANSFORMING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00629">
        <property type="entry name" value="SHCPIDOMAIN"/>
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    <dbReference type="SMART" id="SM00462">
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    <dbReference type="SMART" id="SM00252">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PID" evidence="9">
        <location>
            <begin position="156"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="484"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020297"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031530"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="9">
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            <dbReference type="PROSITE" id="PS50001"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV98104.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027249042.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G3HNB1</accession>
    <name>G3HNB1_CRIGR</name>
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        <submittedName>
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        <submittedName>
            <fullName evidence="13 19">Forkhead box protein P3</fullName>
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    <gene>
        <name evidence="15 19" type="primary">Foxp3</name>
        <name evidence="14" type="ORF">H671_xg20581</name>
        <name evidence="13" type="ORF">I79_012248</name>
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    <organism evidence="13 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000543">
        <property type="protein sequence ID" value="EGW06083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE685850">
        <property type="protein sequence ID" value="ERE64221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505126.3">
        <property type="nucleotide sequence ID" value="XM_003505078.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288985.2">
        <property type="nucleotide sequence ID" value="XM_027433184.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HNB1"/>
    <dbReference type="STRING" id="10029.G3HNB1"/>
    <dbReference type="PaxDb" id="10029-XP_007628674.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027378.1">
        <property type="protein sequence ID" value="ENSCGRP00001023133.1"/>
        <property type="gene ID" value="ENSCGRG00001021426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757421"/>
    <dbReference type="KEGG" id="cge:100757421"/>
    <dbReference type="CTD" id="50943"/>
    <dbReference type="eggNOG" id="KOG4385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161807"/>
    <dbReference type="OMA" id="HCQVDHL"/>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
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    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3HS66</accession>
    <name>G3HS66_CRIGR</name>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18 19 20" type="primary">Cdip1</name>
        <name evidence="14" type="ORF">I79_013692</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18 19 20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18 19 20">17A/GY</strain>
            <tissue evidence="18 19 20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000651">
        <property type="protein sequence ID" value="EGW05594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506394.1">
        <property type="nucleotide sequence ID" value="XM_003506346.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007645047.1">
        <property type="nucleotide sequence ID" value="XM_007646857.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016833005.1">
        <property type="nucleotide sequence ID" value="XM_016977516.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279800.1">
        <property type="nucleotide sequence ID" value="XM_027423999.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279801.1">
        <property type="nucleotide sequence ID" value="XM_027424000.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279802.1">
        <property type="nucleotide sequence ID" value="XM_027424001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HS66"/>
    <dbReference type="STRING" id="10029.G3HS66"/>
    <dbReference type="GlyGen" id="G3HS66">
        <property type="glycosylation" value="2 sites"/>
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    <dbReference type="PaxDb" id="10029-XP_007636527.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023415.1">
        <property type="protein sequence ID" value="ENSCGRP00001019171.1"/>
        <property type="gene ID" value="ENSCGRG00001018691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773437"/>
    <dbReference type="KEGG" id="cge:100773437"/>
    <dbReference type="CTD" id="29965"/>
    <dbReference type="eggNOG" id="ENOG502S2GM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157696"/>
    <dbReference type="OMA" id="YTYKRVC"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
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        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF7">
        <property type="entry name" value="CELL DEATH-INDUCING P53-TARGET PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="13">
        <location>
            <begin position="122"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041883"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW05594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027279800.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027279801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027279802.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="21801" checksum="DB3F5C1F35A72DA8" modified="2011-11-16" version="1">MSNEPPPPYPGGPTAPLLEEKSGAPPTPGRASPAVMQPPPGMPLPSADIAPPPYEPPGHPVPQPGFVPPHMSADGAYMPAGFYPPPGPHPPMGYYPPGPYPPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
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    <name>G3HU57_CRIGR</name>
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            <fullName evidence="14">Pleckstrin homology domain-containing family M member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Plekhm3</name>
        <name evidence="16" type="ORF">I79_014462</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with AKT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000726">
        <property type="protein sequence ID" value="EGW13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003506965.1">
        <property type="nucleotide sequence ID" value="XM_003506917.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252905.1">
        <property type="nucleotide sequence ID" value="XM_027397104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HU57"/>
    <dbReference type="STRING" id="10029.G3HU57"/>
    <dbReference type="PaxDb" id="10029-XP_007638230.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029722.1">
        <property type="protein sequence ID" value="ENSCGRP00001025476.1"/>
        <property type="gene ID" value="ENSCGRG00001023068.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760707"/>
    <dbReference type="KEGG" id="cge:100760707"/>
    <dbReference type="CTD" id="389072"/>
    <dbReference type="eggNOG" id="KOG1829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CVHRELH"/>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045445">
        <property type="term" value="P:myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000257">
        <property type="entry name" value="Pleckstrin homology domain-containing family M member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000271">
        <property type="entry name" value="pleckstrin homology domain-containing family M member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF10">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="353"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027252905.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="85705" checksum="F234AD0EEE87ECE2" modified="2011-11-16" version="1">MEALEVDDISPALEVTEDFFSTFDSKLEKAVQQAEVYGIQEVPELVGHEVFSNITDNGALRNVVSLGSKGNMIWDHCKSRLLETKAQNVFPAKEQLMVQRGTAPDNLSWMEQKEASTFNFFNICQRRRDRPRSVNDLLDESTTFKPGHARSRSDVTHVDWRLVLGTMPLQQQQLSLQGPHFARPSFLLPSPSKVEDAQGNTEHKQTFPNILKKGYLEIRKNHDSYWQSCYAELSPYNLHFYSLDSSGNQSLYATYQLSQFQSISVLGNLEARMVDTVLSDNSQLQLKAESPWEALDWGQKLWEVVHAAAPNYMGRPDEPANSPGLGSQNHCLQKKSSGLLSSPVLHSPKQYQNILKSGTLYRLTVQNNWKAFTFVLSKAYLMAFHPGKLDEDPLLSYNVDVCLAVQIDNLDGCDSCFQVIFPQDVLRLRAETRQRAQEWMEALKTAANAARSSEQNLQVTLRNKPKDQIGGHELRKNKRQSVTTSFLSILTTLSLERGLTAQSFKCAGCQRSIGLSNGKAKVCNYSGWYYCSSCHVDDSFLIPARVVHNWDTSKYKVSKQAKEFLEYVYEEPLIDIQQENPMLYLHAEPLATVVRLRQQLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWRQLNVDESLEEACTMFELSYQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3I3H7</accession>
    <name>G3I3H7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tspan4</name>
        <name evidence="9" type="ORF">I79_017985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH001184">
        <property type="protein sequence ID" value="EGW05553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297991.1">
        <property type="nucleotide sequence ID" value="XM_035442100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I3H7"/>
    <dbReference type="STRING" id="10029.G3I3H7"/>
    <dbReference type="PaxDb" id="10029-XP_007609781.1"/>
    <dbReference type="GeneID" id="100757053"/>
    <dbReference type="CTD" id="7106"/>
    <dbReference type="eggNOG" id="KOG3882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I3H7"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03165">
        <property type="entry name" value="NET-5_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000006">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF40">
        <property type="entry name" value="TETRASPANIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW05553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035297991.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19311" checksum="896527D145F43AC4" modified="2011-11-16" version="1">MAIGFVGCIGALKENKCLLLTFFVLLLLVFLLEATIAVLFFAYSDKIDSYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSDSCGLHAPGTWWKSPCYETVKAWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3I4K4</accession>
    <name>G3I4K4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Copper chaperone for superoxide dismutase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Ccs</name>
        <name evidence="18" type="ORF">I79_018386</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Delivers copper to copper zinc superoxide dismutase (SOD1).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4. Interacts with SLC31A1(via C-terminal domain); this interaction is Cu(1+)-mediated. The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001255">
        <property type="protein sequence ID" value="EGW06367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510183.3">
        <property type="nucleotide sequence ID" value="XM_003510135.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264462.1">
        <property type="nucleotide sequence ID" value="XM_027408661.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I4K4"/>
    <dbReference type="SMR" id="G3I4K4"/>
    <dbReference type="STRING" id="10029.G3I4K4"/>
    <dbReference type="PaxDb" id="10029-XP_007608930.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001018.1">
        <property type="protein sequence ID" value="ENSCGRP00001000994.1"/>
        <property type="gene ID" value="ENSCGRG00001000769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757246"/>
    <dbReference type="KEGG" id="cge:100757246"/>
    <dbReference type="CTD" id="9973"/>
    <dbReference type="eggNOG" id="KOG4656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KNVWEER"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000004">
        <property type="entry name" value="Copper chaperone for superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000027">
        <property type="entry name" value="Copper chaperone for superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGW06367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027264462.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29281" checksum="725312C94CEA5729" modified="2011-11-16" version="1">MASDSRDGGTMCALEFAVQMTCQSCVDAVHKTLKGVAGVQSVEVQLENQMVLVQTTLPSQEVQALLESTGRQAVLKGMGSGQLQNLGAAVAIVESSNTIRGVVRFLQLTSELCLIEGTIDGLEPGLHGFHVHQYGDLTRDCNSCGDHFNPDGTSHGSPQDTDRHRGDLGNILADADGRATFRIEDKQLKVWDVIGRSLVVDEGEDDLGQGRHPLSKITGNSGKRLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGEGRKDSAQPPAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3I817</accession>
    <name>G3I817_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100761978</name>
        <name evidence="13" type="ORF">I79_019674</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001477">
        <property type="protein sequence ID" value="EGW04487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511256.1">
        <property type="nucleotide sequence ID" value="XM_003511208.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276812.1">
        <property type="nucleotide sequence ID" value="XM_027421011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I817"/>
    <dbReference type="STRING" id="10029.G3I817"/>
    <dbReference type="PaxDb" id="10029-XP_007618410.1"/>
    <dbReference type="GeneID" id="100761978"/>
    <dbReference type="KEGG" id="cge:100761978"/>
    <dbReference type="eggNOG" id="ENOG502T9K9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I817"/>
    <dbReference type="OMA" id="CIHICAR"/>
    <dbReference type="OrthoDB" id="6147321at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15226">
        <property type="entry name" value="7tmA_OR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000012">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Olfactory_Receptors"/>
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        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
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        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="102"/>
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            <begin position="41"/>
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<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CHO K1 cell line</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8 9">17A/GY</strain>
            <tissue evidence="8 9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="similarity">
        <text evidence="1 3">Belongs to the heparin-binding growth factors family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027421949.2"/>
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        <property type="nucleotide sequence ID" value="XM_027421950.2"/>
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        <property type="gene ID" value="ENSCGRG00001021672.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:extracellular region"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:hair follicle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:mesenchymal cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000288">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034394">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Fibroblast growth factor"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
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        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0339">Growth factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044524235" description="Fibroblast growth factor" evidence="3">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGW10318.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023444.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027277751.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22385" checksum="F1838A6248BE3961" modified="2011-11-16" version="1">MHKWILTWILPTLLYRSCFHLVCLVGTISLACNDMSPEQTATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNSYNIMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
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                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSCGRG00001000857.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242:SF359">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="10 13 16" id="KW-0675">Receptor</keyword>
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            <end position="48"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="167"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="230"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="242"/>
            <end position="265"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="42"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGW13575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001115.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027260808.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36262" checksum="D20315661B3BCC95" modified="2011-11-16" version="1">MERRNYSGRVSEFVLLGFPAPAPLRALLFFFSLLAYVLVLTENALIITAIRSHPTLHKPMYFFLANMSFLEIWYVTVTIPKMLDGFISSNQNRGQLISFEGCMTQLYFFLGLGCTECVLLAVMAYDRYVAICHPLHYPVIVSNRLCVQMAAGSWAGGFGISMVKVFLISRLSYCGPNTINHFFCDVSPLLNLSCTDMSTAELTDFILAIFILLGPLSVTGASYMAITGAVMRIPSAAGRHKAFSTCASHLTVVIIFYAASIFIYARPKALSAFDTNKLVSVLYAVIVPLLNPIIYCLRNQEVKRALRRTLHLHQGQDANAKKPGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3IFP0</accession>
    <name>G3IFP0_CRIGR</name>
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        <recommendedName>
            <fullName evidence="8">ORM1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14 15" type="primary">Ormdl1</name>
        <name evidence="10" type="ORF">I79_022563</name>
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    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15">17A/GY</strain>
            <tissue evidence="14 15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ORM family.</text>
    </comment>
    <dbReference type="EMBL" id="JH002420">
        <property type="protein sequence ID" value="EGW04748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513599.1">
        <property type="nucleotide sequence ID" value="XM_003513551.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007652017.2">
        <property type="nucleotide sequence ID" value="XM_007653827.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252634.1">
        <property type="nucleotide sequence ID" value="XM_027396833.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252635.1">
        <property type="nucleotide sequence ID" value="XM_027396834.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IFP0"/>
    <dbReference type="STRING" id="10029.G3IFP0"/>
    <dbReference type="PaxDb" id="10029-XP_007635555.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016716.1">
        <property type="protein sequence ID" value="ENSCGRP00001012482.1"/>
        <property type="gene ID" value="ENSCGRG00001013885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767133"/>
    <dbReference type="KEGG" id="cge:100767133"/>
    <dbReference type="CTD" id="94101"/>
    <dbReference type="eggNOG" id="KOG3319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IVSAFRC"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000303">
        <property type="term" value="P:regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGW04748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027252634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027252635.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17389" checksum="E8262EEA25E0EBB4" modified="2011-11-16" version="1">MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFFSVSVAWTLTNIIHNLGMYVFLHAVKGTPFETPDQGRARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFILNTASLLSVLIPKMPQLHGVRIFGINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3ILI8</accession>
    <name>G3ILI8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Leucine-rich repeat-containing protein 3C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Putative LRRC3-like protein ENSP00000367157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">LOC100763945</name>
        <name evidence="6" type="ORF">I79_024754</name>
        <name evidence="5" type="ORF">I79_025808</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH009661">
        <property type="protein sequence ID" value="EGV91502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JH004081">
        <property type="protein sequence ID" value="EGW15212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003516005.1">
        <property type="nucleotide sequence ID" value="XM_003515957.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279885.1">
        <property type="nucleotide sequence ID" value="XM_027424084.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ILI8"/>
    <dbReference type="STRING" id="10029.G3ILI8"/>
    <dbReference type="PaxDb" id="10029-XP_003515312.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009541.1">
        <property type="protein sequence ID" value="ENSCGRP00001006108.1"/>
        <property type="gene ID" value="ENSCGRG00001008200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763945"/>
    <dbReference type="KEGG" id="cge:100763945"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFMGLQI"/>
    <dbReference type="OrthoDB" id="1416801at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000240">
        <property type="entry name" value="Leucine rich repeat containing 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF217">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007660232" evidence="4">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV91502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGW15212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027279885.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="27378" checksum="340AFF189A9F1762" modified="2011-11-16" version="1">MLLLAPRLLPLLLVIGTGAPVPSPHTLPQGCYIAEEAGEQTFRCSRAGLSAVPSGIPNNTRKLYLDANQLASLPAGAFQHLPVLEELDLSHNVLVHLSGAAFQGLEGTLRHLDLSANQLASVPVAAFTGLQIQVNLSANPWRCDCALQEVLRQVRLAPGSGTGIVCGPGARPDLVGQEFLLLTREEELCGTGRGGTRRSTDVALLVTMGGWLTLVAAYLIHYVWQNRDETRRPLKRAPVQRLVRSEDSSTLSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3ILJ0</accession>
    <name>G3ILJ0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14 18">Olfactory receptor 2AG1</fullName>
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        <submittedName>
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            <taxon>Mammalia</taxon>
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            <taxon>Myomorpha</taxon>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
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                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="protein sequence ID" value="EGW14265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027404994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ILJ0"/>
    <dbReference type="STRING" id="10029.G3ILJ0"/>
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    <dbReference type="Ensembl" id="ENSCGRT00001011488.1">
        <property type="protein sequence ID" value="ENSCGRP00001007450.1"/>
        <property type="gene ID" value="ENSCGRG00001009866.1"/>
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    <dbReference type="KEGG" id="cge:100764228"/>
    <dbReference type="eggNOG" id="ENOG502SIEP">
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    </dbReference>
    <dbReference type="Pfam" id="PF13853">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="10 14 18" id="KW-0675">Receptor</keyword>
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            <end position="48"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
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            <end position="290"/>
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        <source>
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        <source>
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            <dbReference type="Proteomes" id="UP001108280"/>
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            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2002" name="J. Cell Biol." volume="156" first="87" last="99">
            <title>Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells.</title>
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                <person name="Essner R."/>
                <person name="Ryu J.H."/>
                <person name="Palazzo R.E."/>
                <person name="Uetake Y."/>
                <person name="Kuriyama R."/>
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            <dbReference type="PubMed" id="11781336"/>
            <dbReference type="DOI" id="10.1083/jcb.200108088"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="7">Ovary</tissue>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2005-05" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="7">Ovary</tissue>
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    <reference evidence="9" key="3">
        <citation type="journal article" date="2011" name="J. Biotechnol." volume="156" first="227" last="235">
            <title>Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.</title>
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                <person name="Hackl M."/>
                <person name="Rupp O."/>
                <person name="Jakobi T."/>
                <person name="Schneider J."/>
                <person name="Szczepanowski R."/>
                <person name="Bekel T."/>
                <person name="Borth N."/>
                <person name="Goesmann A."/>
                <person name="Grillari J."/>
                <person name="Kaltschmidt C."/>
                <person name="Noll T."/>
                <person name="Puhler A."/>
                <person name="Tauch A."/>
                <person name="Brinkrolf K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="4">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
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                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
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    </reference>
    <reference evidence="8" key="5">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
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    <reference evidence="9" key="6">
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
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    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
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        <property type="molecule type" value="mRNA"/>
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    <dbReference type="KEGG" id="cge:100689465"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22292">
        <property type="entry name" value="cc_Cep135_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN 135KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="270"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="513"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="764"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="918"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1119"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAI93867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="NP_001233652.1"/>
        </source>
    </evidence>
    <sequence length="1145" mass="134208" checksum="7560FA5839089503" modified="2005-06-07" version="1">MTTAAERKYINIRKRLDQLGYRQTLTVESLPLVEKLFSDLVHTTESLRQSRLSCAKAEKDSANCDFCLEPYKLENVRLSRENNELYLELMKLREHSDQHIKELKTTLKKCSHETADLKFLNNQCVHKLQLLERESKAKNEKIQQLQEKNLQAIVQTPGGKKRRIAFRRQRMQIDEPAPPSEVSSYPVPQPEDPYIADLLQVADNRIQELQEEVLQLQEKLKVMENGVRGYSKQIELREREIERLSHALDGGRSPDVLSLESRNKTNEKLIAQLNIQVDFLQQANKELEKHIQELMETKETVTTEVVNLSSRNEKLCQELTEIDQLAQQLERHKEEVLETADKEVGEAKKEIQRNLCEMRNLEEKMSKLQLELDLCHKEKERLNGELLLKSDLETVVHQLEEEKYRLSKKLESFVVTERELTLEVERMRLEHGIKRRDKLPSRLDTFLRGIEEERDYYKKELEKLQHAIQRRTCVYMNYYAREKTSTYKGSEKGDHNSDIHLITRERDELQYMLERFEKYMEDIQSNVKLLTSERDKLSVLYNEAKEELSTLRQEPTNGTVTNSFVNCIEKEKERALSDLRRITAEKEALREKLKNIQEMNLLENSELEKTIEHLTFMNHQLESEKYELQSKILIMKETVESLENKSKLQVQKLSHMTGDSSHQKTEMNSLRINEQLQRSLDDCQHRLSIKRGELESAQEEIKILEEKLEKLSHKMTSESEEAHAMKKTIGVIDKEKDFLQETVDEKTERSPTCKKAFASKEKAIAQMRATVTEYETSLNQLKDTLANRDREVNSLRRQLDATHKELDDVGKSRDISFKENRRLQDDLATMARENQEISMELEAAIQEKEEMKSRVHKYITEVSRWESLMPAKENENKDLLDRFQMLHSRAEDWEIKAQQAEGESSSVRLELLSIDTDRRHLRERVDLLEKEIHEHINAHHAYESQISSMVKAMARLEEELRHIENEKAAVLNDLSSLRELCIKLDSGKDLMTQQLNSKSLELEKATAELENIKSESELFKKQLTSERQTIKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLNLSESKLASQSRETSMLRAKVTQLQADYDNLKRQISSERYERERTIQEMRRHGLPTSPLSSTLKSPIQSPEHINTSLSGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6R1L1</accession>
    <name>TAF7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Transcription initiation factor TFIID subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TAF7</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="29921" last="29929">
            <title>TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis.</title>
            <authorList>
                <person name="Fukuchi J."/>
                <person name="Hiipakka R.A."/>
                <person name="Kokontis J.M."/>
                <person name="Nishimura K."/>
                <person name="Igarashi K."/>
                <person name="Liao S."/>
            </authorList>
            <dbReference type="PubMed" id="15078871"/>
            <dbReference type="DOI" id="10.1074/jbc.M401078200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>CHARACTERIZATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF1; the interaction is direct. Interacts with TAF1, TAF5, TAF11, TAF12, and TAF13, but not with TAF10 or TBP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CIITA and TAF1 and inhibits their acetyltransferase activity, and behaving as a repressor of CIITA- and TAF1-regulated promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CIITA. Phosphorylation at Ser-256 by TAF1 in early G1 phase disrupts binding to TAF1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Ubiquitinated by TRIM26; leading to proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY518896">
        <property type="protein sequence ID" value="AAS13444.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233653.1">
        <property type="nucleotide sequence ID" value="NM_001246724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6R1L1"/>
    <dbReference type="SMR" id="Q6R1L1"/>
    <dbReference type="PaxDb" id="10029-NP_001233653.1"/>
    <dbReference type="GeneID" id="100689466"/>
    <dbReference type="KEGG" id="cge:100689466"/>
    <dbReference type="CTD" id="6879"/>
    <dbReference type="eggNOG" id="KOG4011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000296">
        <property type="term" value="P:spermine transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF6">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000293544" description="Transcription initiation factor TFIID subunit 7">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="236"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q15545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9R1C0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="341" mass="39156" checksum="A4651C8FD4B1D008" modified="2004-07-05" version="1">MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDRVPLAAKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVAPADPKASKKKDKDKEKKFVWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKETENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEEDVNVIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEGLESLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HU01</accession>
    <name>A0A061HU01_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Apolipoprotein C-II</fullName>
            <shortName evidence="16">Apo-CII</shortName>
            <shortName evidence="16">ApoC-II</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">Apolipoprotein C2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Apoc2</name>
        <name evidence="18" type="ORF">H671_21325</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <text evidence="14 16">Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 16">Secreted</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2 16">Belongs to the apolipoprotein C2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <taxon>Myomorpha</taxon>
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            <taxon>Cricetulus</taxon>
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        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
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                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
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            <dbReference type="PubMed" id="23929341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">17A/GY</strain>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">17A/GY</strain>
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    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
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    <reference evidence="7" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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            <end position="11"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ERE66417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027285711.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="69965" checksum="BF338D8A4DF08363" modified="2014-09-03" version="1">MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVDSIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVLQMYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDSDRSDAESEGDEFGHREDSERDNPEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEDDDDDESDDSEAEKQSQKQHKEDSHSDGASAATSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGIRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPSLIQRPKADDASAATIEKKATATISAKPQITNPKAEVTRFVPTALRVRRENKGATAVPQRRSEDDSAVPVAKAAPRSGPSVPVSVQTKDDVYEAFMKEMEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HYJ2</accession>
    <name>A0A061HYJ2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Interleukin-11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Il11</name>
        <name evidence="8" type="ORF">H671_21004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-6 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KE686663">
        <property type="protein sequence ID" value="ERE61181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286487.1">
        <property type="nucleotide sequence ID" value="XM_027430686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HYJ2"/>
    <dbReference type="GeneID" id="100773527"/>
    <dbReference type="CTD" id="3589"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000017">
        <property type="entry name" value="Interleukin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020438">
        <property type="entry name" value="IL-11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020412">
        <property type="entry name" value="IL-11_mml"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16922">
        <property type="entry name" value="INTERLEUKIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16922:SF0">
        <property type="entry name" value="INTERLEUKIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07400">
        <property type="entry name" value="IL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01943">
        <property type="entry name" value="INTLKN11MAML"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01927">
        <property type="entry name" value="INTRLEUKIN11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ERE61181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027286487.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15317" checksum="7EE296E56BF39E36" modified="2014-09-03" version="1">MRDRFPADGDHNLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLMSYLRHVQWLRRAGGPSLKTLEPELGALQARLDRLLRRLQLLTSRLALPQATPDQPSVPLGPPTSAWGSIRAAHAILGGLHLTLDWAVRGLLLLKTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IPN5</accession>
    <name>A0A061IPN5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">14-3-3 protein sigma isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">14-3-3 protein sigma-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100754138</name>
        <name evidence="6" type="ORF">H671_1g1572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE663902">
        <property type="protein sequence ID" value="ERE90596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247671.1">
        <property type="nucleotide sequence ID" value="XM_027391870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IPN5"/>
    <dbReference type="GeneID" id="100754138"/>
    <dbReference type="KEGG" id="cge:100754138"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="4">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ERE90596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027247671.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25290" checksum="1976D146C1CF21EB" modified="2014-09-03" version="1">MEKASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVKEYREKVETELRGVCDTVLGLLDSHLIKEAGEAGSRVFYLKMKGDYYRYLAEVATGDDKKRIVDSAGSAYQEAMDISKKEMTPTNPICLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMANLHSLNEDSYKDSTLFMQLLRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IRF3</accession>
    <name>A0A061IRF3_CRIGR</name>
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        <submittedName>
            <fullName evidence="13 14 17">Lysophosphatidic acid receptor</fullName>
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    <gene>
        <name evidence="14 17" type="primary">Lpar2</name>
        <name evidence="13" type="ORF">H671_1g1169</name>
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    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KE663643">
        <property type="protein sequence ID" value="ERE91175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003499110.1">
        <property type="nucleotide sequence ID" value="XM_003499062.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250408.1">
        <property type="nucleotide sequence ID" value="XM_027394607.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IRF3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018340.1">
        <property type="protein sequence ID" value="ENSCGRP00001014103.1"/>
        <property type="gene ID" value="ENSCGRG00001015085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753903"/>
    <dbReference type="KEGG" id="cge:100753903"/>
    <dbReference type="CTD" id="9170"/>
    <dbReference type="GeneTree" id="ENSGT01120000271896"/>
    <dbReference type="OMA" id="RTYLAVW"/>
    <dbReference type="OrthoDB" id="5987098at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070915">
        <property type="term" value="F:lysophosphatidic acid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000025">
        <property type="entry name" value="Lysophosphatidic acid receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004065">
        <property type="entry name" value="LPA_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004066">
        <property type="entry name" value="LPA_rcpt_EDG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01528">
        <property type="entry name" value="EDG4RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01527">
        <property type="entry name" value="LPARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="46"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ERE91175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027250408.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39231" checksum="1429F3C84E8F02DE" modified="2014-09-03" version="1">MGQCYYNETIGFFYNNSGKELSLHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGMAYLFLMFHTGPRTARLSIKGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVTLIVGVWVAALGLGLLPAHFWHCLCDLDRCSRMVPLFSRSYLAVWALSSLLVFLLMVAVYIRIFFYVRRRVERMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLDCKSCNVLAVEKYFLLLAEANSLVNAVVYSCRDAEMRRTFRRLLCCMCLRWSNHKSAHYSSSARMGASTRIMLPENDHPLTDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2Z6LI68</accession>
    <name>A0A2Z6LI68_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">Snx27</name>
        <name evidence="16" type="ORF">H671_1g1422</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KE663843">
        <property type="protein sequence ID" value="ERE90747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003513914.3">
        <property type="nucleotide sequence ID" value="XM_003513866.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249341.1">
        <property type="nucleotide sequence ID" value="XM_027393540.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2Z6LI68"/>
    <dbReference type="SMR" id="A0A2Z6LI68"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025244.1">
        <property type="protein sequence ID" value="ENSCGRP00001021000.1"/>
        <property type="gene ID" value="ENSCGRG00001019965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753773"/>
    <dbReference type="KEGG" id="cge:100753773"/>
    <dbReference type="CTD" id="81609"/>
    <dbReference type="GeneTree" id="ENSGT00950000183212"/>
    <dbReference type="OrthoDB" id="10036828at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098842">
        <property type="term" value="C:postsynaptic early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090128">
        <property type="term" value="P:regulation of synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13338">
        <property type="entry name" value="FERM-like_C_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01777">
        <property type="entry name" value="FERM_F1_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.60:FF:000002">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000075">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037827">
        <property type="entry name" value="SNX27_FERM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037835">
        <property type="entry name" value="SNX27_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="159"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="271"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ERE90747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027249341.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61029" checksum="F2320C8558DF9C44" modified="2018-10-10" version="1">MADEDGEGIHPSAPHRNGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNGVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H846</accession>
    <name>A0A3L7H846_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA/RNP complex-1-interacting phosphatase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual specificity protein phosphatase 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphatase that interacts with RNA/RNP complex 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Dusp11</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. May interact with SFRS7 and SFRS9/SRP30C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007648875.1">
        <property type="nucleotide sequence ID" value="XM_007650685.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027284610.1">
        <property type="nucleotide sequence ID" value="XM_027428809.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H846"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013890.1">
        <property type="protein sequence ID" value="ENSCGRP00001009671.1"/>
        <property type="gene ID" value="ENSCGRG00001011740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770939"/>
    <dbReference type="CTD" id="8446"/>
    <dbReference type="GeneTree" id="ENSGT00940000155847"/>
    <dbReference type="OMA" id="NRIPERW"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17665">
        <property type="entry name" value="DSP_DUSP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000064">
        <property type="entry name" value="RNA/RNP complex-1-interacting phosphatase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF18">
        <property type="entry name" value="RNA_RNP COMPLEX-1-INTERACTING PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="61"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027284610.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38325" checksum="15C8F4182AC6A0F2" modified="2019-02-13" version="1">MNQWHCGRNGRGRGRDFASRAAPKKKVSNHIPERWKDYLPVGQRMPGTRFIAFKVPLQKKYEAKLMPEECFSPLDLFNKIQEQNEELGLIIDLTYTQRYYKAEDLPETISYIKILTVGHQVPNSNTIFKFKSAVKEFLKKNKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGMRPDDAIELFNRCRGHCIERQNYIESLQNRHVRKYRNVSTSRSGGLEDSAHLMDQVNSTNKPVSQGPRNNQPAGRPPPSRHFHTQTQNAQQSFRKFSQNKSVYQRGLIPPPGPAGEDYSQRKFFWNLKPNGSQATQNKKWTSGSYQRPFYPAYWGWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HQA3</accession>
    <name>A0A3L7HQA3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 3A</fullName>
            <ecNumber evidence="16">1.14.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">LOC100773351</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_027269458.1">
        <property type="nucleotide sequence ID" value="XM_027413657.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HQA3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011896.1">
        <property type="protein sequence ID" value="ENSCGRP00001007819.1"/>
        <property type="gene ID" value="ENSCGRG00001010181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773351"/>
    <dbReference type="KEGG" id="cge:100773351"/>
    <dbReference type="GeneTree" id="ENSGT00950000182958"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050649">
        <property type="term" value="F:testosterone 6-beta-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070989">
        <property type="term" value="P:oxidative demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20650">
        <property type="entry name" value="CYP3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000096">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008072">
        <property type="entry name" value="Cyt_P450_E_CYP3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF49">
        <property type="entry name" value="CYTOCHROME P450 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01689">
        <property type="entry name" value="EP450IICYP3A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027269458.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="58282" checksum="CFC453B49A72A948" modified="2019-02-13" version="1">MDLTSVLSLETWVLLAISLVLLYRLGTHKHDIFKKQGIPGPKPLPFLGTLLSYYKGVWKFDIECRKKYGKIWGLFDGQTPLFSVTDTEMIKNVLVKECYSVFTNRRDFGPVGLMSKAVSISKDEEWKRIRALLSPTFTSGKLKEMFPIIEQYGDILVKYLRREAEKGKPVITKEVFGAYSMDVITSTAFGVSVDSLNNPKDPFVEKARKLLRFDFFDPLFLSVVLFPFITPIYERLNVSLFPKDSIEFFRKFVYKMKEHRLDYNQKHRVDFLQLMMNAHDNSKDKESHKALSDMEIIAQSIIFIFAGYETTSSTLAFALYLLATHPDIQKKLQEEIDVALPNKTRPTYDKVMEMEYLDMVMNETLRLYPIGNRLERVCKRDVQMDGVFVPKGSIVMVPVFALHYDPQYWPEPEEFRPERFSKENKGSIDPYVFMPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQMPMKLSRKAMLQPEKPIVLKVVPRSAIITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HXU9</accession>
    <name>A0A3L7HXU9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Potassium channel subfamily K member 18</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Potassium channel, subfamily K, member 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Kcnk18</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263276.1">
        <property type="nucleotide sequence ID" value="XM_027407475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HXU9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020820.1">
        <property type="protein sequence ID" value="ENSCGRP00001016576.1"/>
        <property type="gene ID" value="ENSCGRG00001016865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774565"/>
    <dbReference type="KEGG" id="cge:100774565"/>
    <dbReference type="CTD" id="338567"/>
    <dbReference type="GeneTree" id="ENSGT00700000104522"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032829">
        <property type="term" value="P:regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF346">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="108"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027263276.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44385" checksum="37BDE4B1124D1138" modified="2019-02-13" version="1">MEAEEPPEGRGCCPEVLGTAKRCCHEALGKLLPGLCFLCCLVTYALVGAALFSAVEGRPDPEAEENPELKKFLDDLCSILKCNRTEVEGNRKALCEHLQKMKPQWFKADWSFLSALYFCCTVFSTVGYGHLYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDTLATILSRAYNRFQALLCLPRAPSEWCSSLLCRRQPDSRPVDEAIPQIVISAGADADELLEPQPYREPAPPSCGVELFERLVAREKQDKLQPPMRPIEKSSSCPELELGRLSCSILSNLDEVGQQVERLDIPLPVIALVIFAYISCAAAILPFWETELGFEDAFYFCFVTLTTIGFGDIKLNRPHFFLFFSIYIIVGMEIVFIAFKLMQNRLLRAYKTLMLFFCKREVSLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I380</accession>
    <name>A0A3L7I380_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 107</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 107 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">Ccdc107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_016832398.2">
        <property type="nucleotide sequence ID" value="XM_016976909.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027259046.1">
        <property type="nucleotide sequence ID" value="XM_027403245.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A3L7I380"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029438.1">
        <property type="protein sequence ID" value="ENSCGRP00001025192.1"/>
        <property type="gene ID" value="ENSCGRG00001022872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773807"/>
    <dbReference type="KEGG" id="cge:100773807"/>
    <dbReference type="CTD" id="203260"/>
    <dbReference type="OrthoDB" id="9904035at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038779">
        <property type="entry name" value="CCDC107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37345">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37345:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594447" evidence="3">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027259046.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29107" checksum="06253F34DE35E9F3" modified="2019-02-13" version="1">MAGAGPVSSVLGLLLVSALFGVLGERPSPDQGAHSERRSQVGPGSTEPRRRPPPKDQRERARAGALPLGALYTAAVVAFVLYKCLQGPDEAAILQEEKNKKKSLQSEQQLMQLTQQLAQTEQHLNNLMTQLDPLFERVTTLVGTQRELLNMKLKTIHQLLQDCNPDLSVHIPGKRSGGDGLETEAGKLEQADLSLTKATIPFPKHLGKEDQQGAGDCEAWEGPINWSPDSWNLAPSWEVEQGLRRRWHKTVTKDPARNGEQPLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I4N2</accession>
    <name>A0A3L7I4N2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Rpf2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003504952.1">
        <property type="nucleotide sequence ID" value="XM_003504904.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257977.1">
        <property type="nucleotide sequence ID" value="XM_027402176.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I4N2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001008593.1">
        <property type="protein sequence ID" value="ENSCGRP00001005570.1"/>
        <property type="gene ID" value="ENSCGRG00001007331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770065"/>
    <dbReference type="KEGG" id="cge:100770065"/>
    <dbReference type="CTD" id="84154"/>
    <dbReference type="GeneTree" id="ENSGT00390000007279"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="8">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027257977.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35400" checksum="8E09BDDCDBDBDCDE" modified="2019-02-13" version="1">MDALDKVIKPKTKRAKRFLEKREPKVSENIKNAMLIKGGNANATVTQVLRDMYALKKPYGVLYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLIIGRMYDYHVLDMIELGIEKFVSLKDIKTSKCPEGTKPMLIFAGDDFDVTEDYRRLKNLLIDFFRGPTVSNVRLAGLEYVLHFTALNGKVYFRSYKLLLKKSGCRTPRIELEEMGPSMDLVLRRTHLASDDLYKLSMKMPKALKPKKRKNISQDTFGTTFGRIHMQKQDLSKLQTRKMKGLKKRPAETGTENQGKKSKRIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I9H5</accession>
    <name>A0A3L7I9H5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 22">4'-phosphopantetheine phosphatase</fullName>
            <ecNumber evidence="22">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">Pank4</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21 22">Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68340"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177302"/>
            <dbReference type="ChEBI" id="CHEBI:177303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:68341"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68328"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16753"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68329"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68336"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177300"/>
            <dbReference type="ChEBI" id="CHEBI:177301"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:68337"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="22">Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with PKM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the type II pantothenate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the type II pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="22"/>
    <dbReference type="RefSeq" id="XP_027254302.1">
        <property type="nucleotide sequence ID" value="XM_027398501.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I9H5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016309.1">
        <property type="protein sequence ID" value="ENSCGRP00001012076.1"/>
        <property type="gene ID" value="ENSCGRG00001013559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768771"/>
    <dbReference type="KEGG" id="cge:100768771"/>
    <dbReference type="CTD" id="55229"/>
    <dbReference type="GeneTree" id="ENSGT00940000158896"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1700.10:FF:000001">
        <property type="entry name" value="Pantothenate kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pantothenate kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pantothenate kinase 4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pantothenate kinase 4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1700.10">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.20">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035073">
        <property type="entry name" value="At2g17340_3_helix_bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015844">
        <property type="entry name" value="PanK_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036939">
        <property type="entry name" value="PanK_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 22" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-0944">Nitration</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="24">
        <location>
            <begin position="452"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029347"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR036939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027254302.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="86237" checksum="EB5A2A6CFF4DF4D2" modified="2019-02-13" version="1">MAERGASGGGSGGDSLDKSITLPPDEIFRNLENAKRFAIDIGGSLTKLAYYSTVQHKVAKVRSFDHPGKDVEQDHEPPYEISVQEEITARLHFIKFENTYMEACLDFIRDHLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFMYQKDSDPEFRFQTNHPNIFPYLLVNIGSGVSIVKVETEDRFEWIGGSSIGGGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQDIYGGAHQTLGLSGNLIASSFGKSATADREFSKEDMAKSLLHMISNDIGQLACLYAKLHGLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQDSPNQYSWGENYAASSGLMSTSPELCPTQRARSGTFDLLEMDRLERPLVNLPLLLDPSSYVPDTVDLTDDALARQYWLTCFEEALDGVVKRAVASQPESIDAAERAEKFRQKYWSKLQTLRHQPFAYGTLTVRSLLDTREHCLNEFNFPDPYSKVKQKENGLALKCFQSVTRSLDSLGWEERQLALVKGLLAGNVFDWGAKAVSDVLESDPQFGFEEAKRKLQERPWLVDSYTKWLQRLKGPPHKCALIFADNSGIDIILGVFPFVRELLFRGTEVILACNSGPALNDVTYSESLIVAEHIAAMDPIICSALREDRLLLVQTGSSSPCLDLSRLDKGLAVLVRERGADLVVIEGMGRAIHTNYHALLCCESLKLAVVKNAWLAERLGGQLFSVIFKYEVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IBE5</accession>
    <name>A0A3L7IBE5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Ankyrin repeat and SOCS box protein 8</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ankyrin repeat and SOCS box-containing 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13 14" type="primary">Asb8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14">17A/GY</strain>
            <tissue evidence="13 14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003512950.1">
        <property type="nucleotide sequence ID" value="XM_003512902.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007651483.1">
        <property type="nucleotide sequence ID" value="XM_007653293.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252246.1">
        <property type="nucleotide sequence ID" value="XM_027396445.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027252247.1">
        <property type="nucleotide sequence ID" value="XM_027396446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IBE5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011860.1">
        <property type="protein sequence ID" value="ENSCGRP00001007787.1"/>
        <property type="gene ID" value="ENSCGRG00001010162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753972"/>
    <dbReference type="KEGG" id="cge:100753972"/>
    <dbReference type="CTD" id="140461"/>
    <dbReference type="GeneTree" id="ENSGT00940000159366"/>
    <dbReference type="OMA" id="NCMHGIL"/>
    <dbReference type="OrthoDB" id="10258888at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000274">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000303">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027252246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027252247.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="31706" checksum="D53E4C6943A8FF76" modified="2019-02-13" version="1">MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNHECVRTLLESGASVNALDYNNDTPLSWAAMKGNLESVSILLEYGAEVKVINLKGQTPISRLVALLVRGLGTKKEDSCFELLHRAVGHFELRKNGTMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRHSLGPLYLPNAVKGLPLPASLKDYLLLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LE37</accession>
    <name>A0A8C2LE37_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox protein Hox-D13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Hoxd13</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027275851.1">
        <property type="nucleotide sequence ID" value="XM_027420050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LE37"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002081.1">
        <property type="protein sequence ID" value="ENSCGRP00001001763.1"/>
        <property type="gene ID" value="ENSCGRG00001001661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753293"/>
    <dbReference type="KEGG" id="cge:100753293"/>
    <dbReference type="CTD" id="3239"/>
    <dbReference type="GeneTree" id="ENSGT00940000161457"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060602">
        <property type="term" value="P:branch elongation of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030539">
        <property type="term" value="P:male genitalia development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060571">
        <property type="term" value="P:morphogenesis of an epithelial fold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060527">
        <property type="term" value="P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060687">
        <property type="term" value="P:regulation of branching involved in prostate gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000084">
        <property type="entry name" value="Homeobox protein Hox-D13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051003">
        <property type="entry name" value="AP_axis_regulatory_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022067">
        <property type="entry name" value="HoxA13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45804:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45804">
        <property type="entry name" value="SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12284">
        <property type="entry name" value="HoxA13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027275851.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="35933" checksum="593BF59A65B2D03A" modified="2022-01-19" version="1">MSRSGTWDMDGLRADGGAAGAAPASSSSSVAAPGQCRGFLSAPVFAGTHTGRAAAAAAAAAAAAAAASSFAYPGTSERTGSSSSSSSSAVIATRPEAPVAKECPAPAAAATAAAPPGAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPTNEVPTRAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCAKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LG70</accession>
    <name>A0A8C2LG70_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase RNF115</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">RING finger protein 115</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">RING-type E3 ubiquitin transferase RNF115</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Rab7-interacting RING finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Zinc finger protein 364</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Rnf115</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with RAB7A. Interacts with EGFR and FLT3. Interacts with BST2. Interacts with STX17. Interacts with YWHAE.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027249525.1">
        <property type="nucleotide sequence ID" value="XM_027393724.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LG70"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002475.1">
        <property type="protein sequence ID" value="ENSCGRP00001001996.1"/>
        <property type="gene ID" value="ENSCGRG00001002010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773103"/>
    <dbReference type="KEGG" id="cge:100773103"/>
    <dbReference type="CTD" id="27246"/>
    <dbReference type="GeneTree" id="ENSGT00940000157203"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042059">
        <property type="term" value="P:negative regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034122">
        <property type="term" value="P:negative regulation of toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034123">
        <property type="term" value="P:positive regulation of toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16800">
        <property type="entry name" value="RING-H2_RNF115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000069">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027249525.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33980" checksum="77732145EF0EC936" modified="2022-01-19" version="1">MAEASAAGADAGSSVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTDDSSFLGGGGSRIDDSTSTHFAEFWDRLDHTMFLQDFRSFLTSNPLDQDNRANERGHQTHTDFWGPSRPPRLPMTRRYRSRGSTRPDRSPAIEGIIQQIFAGFFANSAIPGSPHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDTGLECPVCKEDYTVEEKVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQTQSSETSASNRFSNDSQLHDRWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LGC7</accession>
    <name>A0A8C2LGC7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G protein-coupled receptor 162</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Probable G-protein coupled receptor 162 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">LOC100768504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027284052.1">
        <property type="nucleotide sequence ID" value="XM_027428251.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LGC7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003802.1">
        <property type="protein sequence ID" value="ENSCGRP00001002767.1"/>
        <property type="gene ID" value="ENSCGRG00001003162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768504"/>
    <dbReference type="KEGG" id="cge:100768504"/>
    <dbReference type="GeneTree" id="ENSGT00390000017213"/>
    <dbReference type="OrthoDB" id="9887972at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15906">
        <property type="entry name" value="7tmA_GPR162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022347">
        <property type="entry name" value="GCR_153/162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022348">
        <property type="entry name" value="GPR162"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16518">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 153, 162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16518:SF6">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 162-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01991">
        <property type="entry name" value="GPR153GPR162"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01993">
        <property type="entry name" value="GPR162"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027284052.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="63927" checksum="C9C5A13840634AC6" modified="2022-01-19" version="1">MARGGLGAEEASLRSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASSDYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVVGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRAQQARKAGGSVGAKVGGLGGLGTRPAFEVPAIVVEDTRGKRRSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADVRTVWEQCVAIMSEDDGDDDGACDDYTDGRVCKIRFDANGATGSGGRDPTQVKLLPGRHMLFPPLERVHYLQVPLSRRLSHDETNIFSTPRAPGSFLHKWSSSDDIRVLPAQSRALGGPPEYLGQRHRLGDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPGFFREEITTFIDETPLPSPTASPGPSPRRPRPLGFSPRRLSLGSPDSRPVGLPLGLSAGRRCSLTGSEGSSRAWGRPWGPGNPIFSQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LQ91</accession>
    <name>A0A8C2LQ91_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Serine palmitoyltransferase small subunit A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Serine palmitoyltransferase, small subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">LOC113835711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SPTSS family. SPTSSA subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272120.1">
        <property type="nucleotide sequence ID" value="XM_027416319.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LQ91"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011369.1">
        <property type="protein sequence ID" value="ENSCGRP00001007341.1"/>
        <property type="gene ID" value="ENSCGRG00001009767.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113835711"/>
    <dbReference type="KEGG" id="cge:113835711"/>
    <dbReference type="GeneTree" id="ENSGT00390000002766"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051900">
        <property type="entry name" value="SPT_small_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47084">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47084:SF1">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027272120.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8438" checksum="ED4F1D3B1104D59C" modified="2022-01-19" version="1">MAGMGLARAWKQMSWFYYQYLLVTALYMLEPWERTVFNSMLVSVVGMALYTGYVFMPQHIMAILHYFEIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LR34</accession>
    <name>A0A8C2LR34_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymosin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Tmsb15b</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
            <location evidence="1 5">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305682.1">
        <property type="nucleotide sequence ID" value="XM_035449791.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316530.1">
        <property type="nucleotide sequence ID" value="XM_035460639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LR34"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011227.1">
        <property type="protein sequence ID" value="ENSCGRP00001007210.1"/>
        <property type="gene ID" value="ENSCGRG00001009656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756468"/>
    <dbReference type="KEGG" id="cge:100756468"/>
    <dbReference type="CTD" id="286527"/>
    <dbReference type="GeneTree" id="ENSGT01060000248842"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.520:FF:000001">
        <property type="entry name" value="Thymosin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12021">
        <property type="entry name" value="THYMOSIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12021:SF11">
        <property type="entry name" value="THYMOSIN BETA-15A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001828">
        <property type="entry name" value="Thymosin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00500">
        <property type="entry name" value="THYMOSIN_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035305682.1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5332" checksum="B10E25A556ED59C2" modified="2022-01-19" version="1">MSDKPDLSEVETFDRSKLKKTNTEEKNTLPSKETIQQEKEYNKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LZ39</accession>
    <name>A0A8C2LZ39_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Prex1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts preferentially with RAC2. Interacts with RAC1. Interacts with AUTS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027279176.1">
        <property type="nucleotide sequence ID" value="XM_027423375.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001014731.1">
        <property type="protein sequence ID" value="ENSCGRP00001010510.1"/>
        <property type="gene ID" value="ENSCGRG00001012312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774282"/>
    <dbReference type="KEGG" id="cge:100774282"/>
    <dbReference type="CTD" id="57580"/>
    <dbReference type="GeneTree" id="ENSGT00940000159925"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030217">
        <property type="term" value="P:T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04440">
        <property type="entry name" value="DEP_2_P-Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000055">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000018">
        <property type="entry name" value="Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000090">
        <property type="entry name" value="Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000094">
        <property type="entry name" value="Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000099">
        <property type="entry name" value="Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000141">
        <property type="entry name" value="Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
        <property type="entry name" value="mTOR-Rac_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF6">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="44"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="266"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="16">
        <location>
            <begin position="416"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="16">
        <location>
            <begin position="524"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="620"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1101"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027279176.1"/>
        </source>
    </evidence>
    <sequence length="1644" mass="184649" checksum="8A34BFD345E3C9A9" modified="2022-01-19" version="1">MEAPGSGGGDSGGDPGGDGTQPDARGPGSGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLQRIRQNVVDCVEKGLTEENVKILFSNIEDILEVHKDFLAALEHCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVDDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVSWLLEIGEISKTEEGINLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIPPQEDDYGFDLEEKNKAVVVKSVQRGSLAEMAGLQAGRKIYSINEDLVFLRPFSEVETILNQSFCSRRPLRLLVATKAKETIKIPDHPEALSFQIRGAAPPCVFAVGRGSEAVAAGLCAGQCILKVNGNSVANDGALEVLEHFQAFRSHREEALGLFQWVYHSHEDAQQARASQGAPDEDPQEDDQPDSALPLLSLGPQLSLHDDSAVISLTLDNVHLEHGVVYEYVSTAGAKCHVLEKIVEPRGCFRLAAKILEAFAEDDSVFVQNCGRLMVLSSAIITMSHYEFHNICDTKLESISQRIRCYQEFAVQLKNRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMAYTQHCITTMAAPSWNCSSAVDGDAQGQGLSDSSFWSARGGPSQQDRGLSFLLRQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPCDPPLAEEASSSPPVSEESEVDRTDHGGIKKVCFKVSEDEQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSIHALLKGPVMNRAFEETKHCPMEHSWQEFKQKEECTVRGRNLIQISIQEDPWNLPSSIRTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAVFCQALVAAVCTFSEQLLAALDYRYNNNGEYEESSRDASRKWLEQVAATGVLLHWQSLLAPATVKEERTMLEDIWVTLSELDNVTFSFKQLDETSVANTNVFYHIEGSRQALKVVFYLDGFHFSRLPSRLEGGASLRLHTVLFTKALENVEGPPPPGSQAAEDLQQEINAQSLEKVQQYYRKLRAFYLERSNLPTDAGTTAVKIDQLIRPINALDELYRLMKSFVHPKAGAAGSLGAGLIPISSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCVMQATDIMRKQGPRVEILAKNLRIKDPMPQGAPRLYRLCQPPVDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M287</accession>
    <name>A0A8C2M287_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">MORC family CW-type zinc finger protein 4 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Microrchidia 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Morc4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027289466.1">
        <property type="nucleotide sequence ID" value="XM_027433665.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M287"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016114.1">
        <property type="protein sequence ID" value="ENSCGRP00001011881.1"/>
        <property type="gene ID" value="ENSCGRG00001013404.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762949"/>
    <dbReference type="KEGG" id="cge:100762949"/>
    <dbReference type="CTD" id="79710"/>
    <dbReference type="OrthoDB" id="757982at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.100:FF:000003">
        <property type="entry name" value="MORC family CW-type zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000035">
        <property type="entry name" value="MORC family CW-type zinc finger protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045261">
        <property type="entry name" value="MORC_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336:SF22">
        <property type="entry name" value="MORC FAMILY CW-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23336">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="10">
        <location>
            <begin position="417"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="724"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="752"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027289466.1"/>
        </source>
    </evidence>
    <sequence length="927" mass="105046" checksum="DF36E1379B0E4059" modified="2022-01-19" version="1">MLLYRGAPAGPGVPGGGLARAGSVPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKNKPCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGSMRLGKDALVFTKNGCTLTVGLLSQSYLECIQAQAVIVPVAPFSQQSKKMIVTEDSLPSLEAILNYSIFNSEKDLLSQFDAIPGKKGTRVLIWNVRRNKDGKSELDFDTDQYDILVSDFGAEEKEIGGVTSELPETEYSLRAFCSILYMKPRMKIFLRQKKVTTQMIAKSLADVEHDVYKSPFTNKQVKITFGFSCKYHNQFGVMMYHNNRLIKAFEKVGCQLKPTCGEGVGVIGVVECNFLKPAYNKQDFEYTKEYRSIINALTQKLNAYWKEKTSQENFDTILTSRKIPDQTWVQCDECLKWRKLPGKVDPCTLPARWFCYYNPHPKYRRCSVPEEQERIDEDLYLSKAKQQEETVEKKQKAVESDKHQVLSNPTKSPATQDMAELNDKTIGYEQINTPNLLPSVREENKSPLQLKSLDSSVFQFSSKYKLILGDEPVEKRRRFQTDMTPSPIDYSMSSPYRRVDAAVAYPDGENSHDKSSSERSTPPYLLPEYPEANKNTGQNREAPALCPGSQDQDQESLLPEELEDQMPRLVAEESNRSIENINKEVNKGPFVAVVGVAKGLTDSGAPIQLIPFNREEFVGRRKAAESWNPNPYSVAPATATPGKGKGCQESGGRNMPKIKNQKELEELKRTTEKLERVLAERNLFQQKVEELEQEKNHWHSEFKKAQHELVTYSTQETEGLYWSKKHMGYRQAEFQILKAELERTKEEKQELKEKLKETETHLEVLQKAQASYRNAEGDDLERALAKLTRLRIHVSYLLTSVLPHLELREIGYDSEQVDGILYTVLEANHILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M3J6</accession>
    <name>A0A8C2M3J6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Armadillo-like helical domain containing 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Armadillo-like helical domain containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">Armh1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <reference evidence="1" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_007609642.1">
        <property type="nucleotide sequence ID" value="XM_007611452.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258398.1">
        <property type="nucleotide sequence ID" value="XM_027402597.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M3J6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014459.1">
        <property type="protein sequence ID" value="ENSCGRP00001010238.1"/>
        <property type="gene ID" value="ENSCGRG00001012176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755338"/>
    <dbReference type="KEGG" id="cge:100755338"/>
    <dbReference type="CTD" id="339541"/>
    <dbReference type="GeneTree" id="ENSGT00390000001593"/>
    <dbReference type="OMA" id="ETICECY"/>
    <dbReference type="OrthoDB" id="278163at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041090">
        <property type="entry name" value="DUF5578"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17741">
        <property type="entry name" value="DUF5578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027258398.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49601" checksum="4EB2FF4E15559107" modified="2022-01-19" version="1">MTSIKEQAAISRLLSFLQEWDNASRNLRSQILTKFIDSNEGKTGPELEQEFSQGASLFLIRLTTWLRITYMTGLDLEKILRSIGIFLSAVSSNRYLIEFLEIGGVLTLLEILGLEKIKEEDKRESVKLLQIIASTGRKYKELICESYGVRSIAEFLAKSQSEETQEEVQILLDTLLHGNPKYQNQVYKGLIALLPCGSPKAQQLALQTLRTAQSIIGATHPSIVDCVLTVLGTMHLEVQYEAIELIKDLIHYDVRLPLLKGLVALLIPSVKETSKLQANIFTESSILQVTTQLPVFLKQAAAAKTIGILARSDLKVAEELLYLRVIHSLMTAMGNTDHSNSQRLASLTLEFFVQMFPLVEEHVHKSMGEELYQLFLSNAEILYAKMDSIQADILAANKVNVSKALCLCEGTTNSCFSFFMGPGDVNEVEYVTHFEKHQPESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M7R5</accession>
    <name>A0A8C2M7R5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Med24</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303504.1">
        <property type="nucleotide sequence ID" value="XM_035447613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M7R5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019033.1">
        <property type="protein sequence ID" value="ENSCGRP00001014795.1"/>
        <property type="gene ID" value="ENSCGRG00001015568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759120"/>
    <dbReference type="CTD" id="9862"/>
    <dbReference type="GeneTree" id="ENSGT00390000016438"/>
    <dbReference type="OrthoDB" id="21216at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046966">
        <property type="term" value="F:nuclear thyroid hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021429">
        <property type="entry name" value="Mediator_Med24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11277">
        <property type="entry name" value="Med24_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035303504.1"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112064" checksum="96D3123D558055B4" modified="2022-01-19" version="1">MKVVNLKQAILQAWKERWSDYQWAINMKKFFPRGATWDILNLAEALLEQAMIGPSPNPLILSYLKYSISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECMGLCRALLSALHWLLRCTAASAERLQEGLEAGTPATGEKQLALCLQCLEKTLSSTKNRALLHIAKLEEASLHTSQGLGQGGTRANQPTASWTAIEHCLLKLGEILANLSNPQLRSQAEQCDTLIRSIPTMLSVHSEQLHKTGFPTVHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTQELKWTAFTYLKIPQVLVKLKKHLHGEKDFTEDVNSAFEFLLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEVNFASLVGKRTTDRDPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSEASSGEEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLERGWVDSRSIHILDTLLRMGGVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDLPQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSQKGQAASRHKKRHREDIEDYISLFPVEDMQPSKLMRLLSTNEDDANILSSPTDRSMNSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQDSRGSILQFMPFATVSELVKVSAMSSPKVVLAITDLTLPLGRQVAAKAIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MBD2</accession>
    <name>A0A8C2MBD2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20 21 22 23 24" type="primary">Dtx2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21 22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21 22">17A/GY</strain>
            <tissue evidence="20 21 22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the Deltex family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="RefSeq" id="XP_027271997.1">
        <property type="nucleotide sequence ID" value="XM_027416196.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271998.1">
        <property type="nucleotide sequence ID" value="XM_027416197.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027271999.1">
        <property type="nucleotide sequence ID" value="XM_027416198.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272000.1">
        <property type="nucleotide sequence ID" value="XM_027416199.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027272001.1">
        <property type="nucleotide sequence ID" value="XM_027416200.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MBD2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020501.1">
        <property type="protein sequence ID" value="ENSCGRP00001016257.1"/>
        <property type="gene ID" value="ENSCGRG00001016639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764941"/>
    <dbReference type="KEGG" id="cge:100764941"/>
    <dbReference type="CTD" id="113878"/>
    <dbReference type="GeneTree" id="ENSGT00940000157641"/>
    <dbReference type="OrthoDB" id="2449614at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16672">
        <property type="entry name" value="RING-H2_DTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000097">
        <property type="entry name" value="E3 ubiquitin-protein ligase DTX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000004">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000005">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.130:FF:000001">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
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        <property type="entry name" value="WWE_dom"/>
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    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
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    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WWE" evidence="16">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="16">
        <location>
            <begin position="98"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="409"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="248"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016257.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027271997.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027271998.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027271999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027272000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027272001.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="66897" checksum="EB154624B067F875" modified="2022-01-19" version="1">MAMAPSSSLPQVYPSPVVVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRSVRRHLFSQNSAPGQGIVWEWLGDDGSWIPYEASVCDYLEQQVARGIQVVDLAPLGYNYTVNYATLTQTNKTSSFCRNVRRQVGPVYPVTSVIAPPGHMGLVCSCQQCLHGSGTGPVSGRYRHSMTNLPAYPAPQAPHRTATVFGAHQAFAPYNKPSLSGARSAPRLNTTNPWGTTPPVPGSQSLFHSSLSHLGPQLLPSGPSTSSGASASFPSGPSSSSPGSAPTTVPVQMPKPSRVQQALAGMTSVLSAIGLPVCLSRAPRPTGPPASRPASKGHSSVKRLRKMSVKDGPPKPEPEHVIRKYTEELRVAPDEDCIICMEKLSVASGYTDVTDGSTLGPMAVGRLTKCSHTFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVLRVHVSLPGHEDCGTILIVYNIPHGIQGPEHPSPGKPFTARGFPRQCYLPDNPQGRKVLELLKVAWKRRLIFTVGTSNTTGETDTVVWNEIHHKTEMDRNLTGHGYPDPNYLQNVLAELAAQGVTEDCLEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MK24</accession>
    <name>A0A8C2MK24_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glucose-6-phosphate exchanger SLC37A1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Solute carrier family 37 (glycerol-3-phosphate transporter), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Slc37a1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71535"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307696.1">
        <property type="nucleotide sequence ID" value="XM_035451805.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313014.1">
        <property type="nucleotide sequence ID" value="XM_035457123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MK24"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024570.1">
        <property type="protein sequence ID" value="ENSCGRP00001020326.1"/>
        <property type="gene ID" value="ENSCGRG00001019505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765147"/>
    <dbReference type="KEGG" id="cge:100765147"/>
    <dbReference type="CTD" id="54020"/>
    <dbReference type="GeneTree" id="ENSGT00940000159245"/>
    <dbReference type="OMA" id="WRIQIFA"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061513">
        <property type="term" value="F:glucose 6-phosphate:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17344">
        <property type="entry name" value="MFS_SLC37A1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000050">
        <property type="entry name" value="glucose-6-phosphate exchanger SLC37A2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000028">
        <property type="entry name" value="Sugar phosphate exchanger 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044740">
        <property type="entry name" value="SLC37A1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF11">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="27"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035307696.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="57707" checksum="26EA75F0394218AD" modified="2022-01-19" version="1">MARLPVGIRFIISFSRDQWYRAFIFMLTFLLYASFHLSRKPISIVKGELHKQCAAGDEPEPRFGGPSSSTRHGPTHWLLNNETDCGWAPFDKNNYQQLLGALDYSFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDIKCSSTLPTHSKISENGMNRFRLQKQTTHTEKNGPLDPERQCLLLSDGKSSLHPSHIVVLPSDSSGSMAAISFTGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKQAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSKMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGFISPSGWSNVFYMLMFADACALLFLIRLIHKELSCPGPTAGIQAPLKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MLP8</accession>
    <name>A0A8C2MLP8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma</fullName>
            <ecNumber evidence="16">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 28 29" type="primary">Plcg2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28 29" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28 29">17A/GY</strain>
            <tissue evidence="28 29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.</text>
    </comment>
    <comment type="function">
        <text evidence="14">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts constitutively with THEMIS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="16"/>
    <dbReference type="RefSeq" id="XP_003495178.1">
        <property type="nucleotide sequence ID" value="XM_003495130.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266579.1">
        <property type="nucleotide sequence ID" value="XM_027410778.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298599.1">
        <property type="nucleotide sequence ID" value="XM_035442708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MLP8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025228.1">
        <property type="protein sequence ID" value="ENSCGRP00001020984.1"/>
        <property type="gene ID" value="ENSCGRG00001019941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752475"/>
    <dbReference type="KEGG" id="cge:100752475"/>
    <dbReference type="CTD" id="5336"/>
    <dbReference type="OMA" id="YMARVFK"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097708">
        <property type="term" value="C:intracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140031">
        <property type="term" value="F:phosphorylation-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061760">
        <property type="term" value="P:antifungal innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002316">
        <property type="term" value="P:follicular B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032959">
        <property type="term" value="P:inositol trisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031663">
        <property type="term" value="P:lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002732">
        <property type="term" value="P:positive regulation of dendritic cell cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032733">
        <property type="term" value="P:positive regulation of interleukin-10 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032735">
        <property type="term" value="P:positive regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032743">
        <property type="term" value="P:positive regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032747">
        <property type="term" value="P:positive regulation of interleukin-23 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060907">
        <property type="term" value="P:positive regulation of macrophage cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150078">
        <property type="term" value="P:positive regulation of neuroinflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900227">
        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060100">
        <property type="term" value="P:positive regulation of phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903428">
        <property type="term" value="P:positive regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070884">
        <property type="term" value="P:regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001878">
        <property type="term" value="P:response to yeast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002223">
        <property type="term" value="P:stimulatory C-type lectin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16215">
        <property type="entry name" value="EFh_PI-PLCgamma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13362">
        <property type="entry name" value="PH_PLC_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13234">
        <property type="entry name" value="PHsplit_PLC_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08592">
        <property type="entry name" value="PI-PLCc_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09932">
        <property type="entry name" value="SH2_C-SH2_PLC_gamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10341">
        <property type="entry name" value="SH2_N-SH2_PLC_gamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11969">
        <property type="entry name" value="SH3_PLCgamma2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056586">
        <property type="entry name" value="EF-hand_PLCG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016279">
        <property type="entry name" value="PLC-gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035023">
        <property type="entry name" value="PLC-gamma_C-SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035024">
        <property type="entry name" value="PLC-gamma_N-SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057061">
        <property type="entry name" value="PLCG_EF-hand_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035723">
        <property type="entry name" value="PLCgamma2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF25">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23329">
        <property type="entry name" value="EF_HAND_1_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23583">
        <property type="entry name" value="EF_HAND_2_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000952">
        <property type="entry name" value="PLC-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 16 19" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 16 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 17" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="12 16" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="22">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="534"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="648"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="771"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="24">
        <location>
            <begin position="932"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="23">
        <location>
            <begin position="1040"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027266579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_035298599.1"/>
        </source>
    </evidence>
    <sequence length="1267" mass="147927" checksum="0382DC4A92FF0D32" modified="2022-01-19" version="1">MTTMVNVDTLPEYEKSQIKRALELGMVMTVFSARKGTSERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKATVSRHKADCCFTIFYGTQFVLSTLSLATDSKEDAMKWLSGLKILHQEAMSASTPTMIESWLRKQIYSVDQTRRNSISLRELKAILPLVNFKVSSVKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFILGNTDRPDASAIHLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLYVDEFLTYLFSRENSIWDEKYDTVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKTQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQAVEEELVQDTTPTELHFGEKWFHKKVERRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGVMKYYLTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDMLMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPIDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLECEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSNSRFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N0I6</accession>
    <name>A0A8C2N0I6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">12S rRNA N(4)-cytidine methyltransferase METTL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methyltransferase 5 domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Methyltransferase-like protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17 18 19 20 21" type="primary">Mettl15</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62524"/>
            <dbReference type="Rhea" id="RHEA-COMP:16109"/>
            <dbReference type="Rhea" id="RHEA-COMP:16110"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:62525"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511007.1">
        <property type="nucleotide sequence ID" value="XM_003510959.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007649720.1">
        <property type="nucleotide sequence ID" value="XM_007651530.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016835424.1">
        <property type="nucleotide sequence ID" value="XM_016979935.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278101.1">
        <property type="nucleotide sequence ID" value="XM_027422300.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278102.1">
        <property type="nucleotide sequence ID" value="XM_027422301.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278103.1">
        <property type="nucleotide sequence ID" value="XM_027422302.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278104.1">
        <property type="nucleotide sequence ID" value="XM_027422303.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027298303.1">
        <property type="nucleotide sequence ID" value="XM_027442502.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302085.1">
        <property type="nucleotide sequence ID" value="XM_035446194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317414.1">
        <property type="nucleotide sequence ID" value="XM_035461523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N0I6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030899.1">
        <property type="protein sequence ID" value="ENSCGRP00001026652.1"/>
        <property type="gene ID" value="ENSCGRG00001023906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770656"/>
    <dbReference type="KEGG" id="cge:100770656"/>
    <dbReference type="CTD" id="196074"/>
    <dbReference type="GeneTree" id="ENSGT00390000014756"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.170:FF:000002">
        <property type="entry name" value="Probable methyltransferase-like protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00006">
        <property type="entry name" value="16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027278101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027278102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027278103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027278104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035302085.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45594" checksum="B9149D491840967B" modified="2022-01-19" version="1">MLRYSYFCKLYKELFYCWMESGAFNLGICPQAMHTTAAVHTEYESLEETALCGTGKVHRSAEEDSEAIAKLHIPVMVDEVVHCLTPQKGQVFLDMTFGSGGHTKAILQKEPDITIYALDRDPTAYAIAEKLSEVYPKQIQAMLGQFSEAEALLINAGVQPGTIDGVLLDLGCSSMQLDAPERGFSLRKDGPLDMRMDGDRYPDMPTAADVVNGLDQQALASILRAYGEEKHAKKIASAIIQARSIYPILRTQQLASIVAGAFPPSAVYARKDLLQRSSHIATKTFQALRIFVNNELNELYTGLKTAQKFLKTGGRLVALSFHSLEDRIVKRFLLGISMTERFNLSIRQKVKQRSQMDSNIENDRSERGSSVRAPLNWDLLHKKVLTPEDQDVQENPRGRSAKLRAAIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N460</accession>
    <name>A0A8C2N460_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="12">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17 18" type="primary">Gnpda1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18">17A/GY</strain>
            <tissue evidence="17 18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12173"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:12174"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="12"/>
    <dbReference type="RefSeq" id="XP_027253824.1">
        <property type="nucleotide sequence ID" value="XM_027398023.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253825.1">
        <property type="nucleotide sequence ID" value="XM_027398024.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311752.1">
        <property type="nucleotide sequence ID" value="XM_035455861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N460"/>
    <dbReference type="SMR" id="A0A8C2N460"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028966.1">
        <property type="protein sequence ID" value="ENSCGRP00001024720.1"/>
        <property type="gene ID" value="ENSCGRG00001022546.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100689210"/>
    <dbReference type="KEGG" id="cge:100689210"/>
    <dbReference type="CTD" id="10007"/>
    <dbReference type="GeneTree" id="ENSGT00390000014316"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000004">
        <property type="entry name" value="Glucosamine-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF8">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027253824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027253825.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32617" checksum="5FDC8718F2556118" modified="2022-01-19" version="1">MKLIILEHYSQASEWAAKYIRNRIIQFNPGPDKYFTLGLPTGSTPLGCYQKLIEYYKNGDLSFKYVKTFNMDEYVGLPREHPESYHSFMWNNFFKHIDIHPENTHILDGNAADLQVECDAFEEKIRAAGGIELFVGGIGPDGHVAFNEPGSSLVSRTRVKTLAMDTILANARFFDGDLAKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKEIQKSQAAKKPYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N583</accession>
    <name>A0A8C2N583_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Pfkfb3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003494984.1">
        <property type="nucleotide sequence ID" value="XM_003494936.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260924.1">
        <property type="nucleotide sequence ID" value="XM_027405123.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N583"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032456.1">
        <property type="protein sequence ID" value="ENSCGRP00001028208.1"/>
        <property type="gene ID" value="ENSCGRG00001024989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762756"/>
    <dbReference type="KEGG" id="cge:100762756"/>
    <dbReference type="CTD" id="5209"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF41">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="475"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="253"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001028208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027260924.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="62949" checksum="EB988AC5FD60AD0D" modified="2022-01-19" version="1">MPLELTQSRVQKIWVPVDHRPSLPRTCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMRVRKQCALAALRDVKSYLTKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRINCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEYNLQGKIGGDSGLSSRGKKFANALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVSTHRERSDAVKIQHFASVVRPSSYTELDFLSVESAKQDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPTQLPGQNMKSPRSGTESSQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QDI9</accession>
    <name>A0A8C2QDI9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">OTU domain-containing protein 4</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Otud4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with MYD88; the interaction is direct. Interacts with ALKBH3; the interaction is direct. Interacts with USP7; the interaction is direct. Interacts with USP9X; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_007639680.2">
        <property type="nucleotide sequence ID" value="XM_007641490.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260689.1">
        <property type="nucleotide sequence ID" value="XM_027404888.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QDI9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001005286.1">
        <property type="protein sequence ID" value="ENSCGRP00001003632.1"/>
        <property type="gene ID" value="ENSCGRG00001004451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771576"/>
    <dbReference type="KEGG" id="cge:100771576"/>
    <dbReference type="CTD" id="54726"/>
    <dbReference type="OrthoDB" id="10017659at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:antiviral innate immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000660">
        <property type="term" value="P:negative regulation of interleukin-1-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034122">
        <property type="term" value="P:negative regulation of toll-like receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein K63-linked deubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of protein K48-linked deubiquitination"/>
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        <property type="entry name" value="OTU_OTUD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000013">
        <property type="entry name" value="OTU domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OTU_dom"/>
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    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF9">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="19">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="192"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="321"/>
            <end position="448"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="470"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="917"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
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        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
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        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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            <begin position="539"/>
            <end position="551"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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            <end position="1078"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1088"/>
            <end position="1106"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00000707"/>
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    <sequence length="1106" mass="122612" checksum="85ABD5BAA58DFB26" modified="2022-01-19" version="1">MEAAVGAPDGGDRGGAGPLEDATPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIHYLRENREKFEAFIEGPFEEYLKRLENPQEWVGQVEISALSLMYRKDFVIYQEPNVSPSQVTENNFPEKVLLCFSNGNHYDIVYPITYKDSSAVCQSLLYELLYEKVFKTDVSKIMMGLETSEMADESNSEISDSEDDSCKSKSTAATDVNGLKPSGSENPENGGNVADLPLSRKVLKSLNPAVYRNVEYEIWLKSKQAQQKRDYSIAAGLQYEVGDKCHVRLDHNGKFSNADIHGVHSENGPVLSEELGKKHIPKNLKTPPPESWNTVSGKKMKKPNSGQNFHSDTDYRGPKNLSKPIKAPSALPPRLQHPSSGVRQHAFSSHSSGSQSQKSSSEHKNLSRTPSQIIRKPDRERAEDSDHTSREPYYFGLSPEERREKQAIEESRLLYEIQNRDEQAFPALSSPSVSQSPQSSNSSVQRKSSHARDRKGGMRRADAEERKDKDSLRGHTHVDKKTEPSILEISDDKCTRVSSPSKSKTTECPSPVEQKPAEHVSLSNPAPLLVSPEVHLTPAVPSLPATVPAWPSEPTTFGPTGVPAQIPILSVTQTTGPDAAVSQAHLTPSPVPVSIQAVNQPLMPLPQTMSLYQDPLYPGFPCSEKGDRAIAPPYSLCQTGEDLPKDKNILRFFFNLGVKAYSCPMWAPHSYLYPLHQAYMAACRMYPKVPVPVYPQNTWFQEAPPGQSESDCPCTDAHYSMHPEASVNGQMPQAEMGPPAFSSPLVIPPSQVSEGHGQLSYQPELESENAGQLLHAEYEESLSGKNMYPQPSFGPNPFLGPVPIAPPFFPHVWYGYPFQGFVENPVMRQNIVLPSDDKGELDLPLENLDLSKECDSVSAVGEFPEARVEGVHSLSEASVSSKHEGRVEQSSQTRKTDIALASGSPGVEGKAHPPTQILNRERETGSAELEPKRTIQSLKEKPEKVKDPKTAADVVGPGVNSVDRLQRPKEESSEDENEVSNILKSGRPKQFYNQTYGNRKYKSDWGSSGRGGYQHVRGEESWKGQPNRSRDEGFQYHRNVRGRPYRGDRRRSGMGDGHRGQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QGW9</accession>
    <name>A0A8C2QGW9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Platelet-derived growth factor C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Pdgfc</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003500263.1">
        <property type="nucleotide sequence ID" value="XM_003500215.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248724.1">
        <property type="nucleotide sequence ID" value="XM_027392923.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QGW9"/>
    <dbReference type="SMR" id="A0A8C2QGW9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015608.1">
        <property type="protein sequence ID" value="ENSCGRP00001011376.1"/>
        <property type="gene ID" value="ENSCGRG00001013031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765334"/>
    <dbReference type="KEGG" id="cge:100765334"/>
    <dbReference type="CTD" id="56034"/>
    <dbReference type="GeneTree" id="ENSGT00940000158645"/>
    <dbReference type="OMA" id="MLIQLTF"/>
    <dbReference type="OrthoDB" id="8641091at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005161">
        <property type="term" value="F:platelet-derived growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00135">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000010">
        <property type="entry name" value="Platelet derived growth factor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000017">
        <property type="entry name" value="Platelet derived growth factor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633:SF5">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00141">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-0497">Mitogen</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679266" description="Platelet-derived growth factor C" evidence="14">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="16">
        <location>
            <begin position="250"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027248724.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38709" checksum="ADFC37D59104E9BC" modified="2022-01-19" version="1">MLLLGLLLLTSALAGLRTGTRAESNLSSKLQLSSDKEQNGVQDPQHERVVTVSANGSIHSPKFPHTYPRNTVLVWRLVAADENMRIQLTFDERFGLEDPEEDICKYDFVEVEEPSDGSILGCWCGSGTVPGKQTSKGNQIRIRFVSDEYFPSEPGFCIHYSIVMPQVTETTSPSVLPPSALSLDLLNNAVTAFSTLEELIRYLEPDRWQMDLDSLYKPPWQVVGKAFLYGKKNKVMNLNILKEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPRKVTKKYHEVLQLRPKIGVKGLHKSLTDVALEHHEECDCVCKGNTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EZI1</accession>
    <name>A0A9J7EZI1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRPM8 channel-associated factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100753218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play a role in the regulation of the cation channel TRPM8 activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027245521.1">
        <property type="nucleotide sequence ID" value="XM_027389720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7EZI1"/>
    <dbReference type="GeneID" id="100753218"/>
    <dbReference type="KEGG" id="cge:100753218"/>
    <dbReference type="OrthoDB" id="10260387at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.30:FF:000001">
        <property type="entry name" value="TRPM8 channel-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.80:FF:000001">
        <property type="entry name" value="TRPM8 channel-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1250:FF:000001">
        <property type="entry name" value="TRPM8 channel-associated factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1250">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.80">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051244">
        <property type="entry name" value="TCAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15730">
        <property type="entry name" value="EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15730:SF3">
        <property type="entry name" value="TRPM8 CHANNEL-ASSOCIATED FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M60" evidence="4">
        <location>
            <begin position="533"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027245521.1"/>
        </source>
    </evidence>
    <sequence length="911" mass="102075" checksum="6898DBBD0CDAA8EF" modified="2023-06-28" version="1">MATTPDAAFEALMNGVTSWDLPKEFIPCELLLTGEAAFPVMVNDKGQVLIAASSYGQGRLVVISHERYLLHAGLAPFLLNAVRWLCPSPEAPIVVHSTLASLGNILSNSGLEALVQPQPGETLGVYCTDANNDTLTEKLVRFVKRGGGLLIGGQACYWASQHGHDKVLSSFPGNQVTSVAGVYFTDVYGNRDSFEVSKEVPNLTLYVKCEDEIKYDQQQLLEGMSEMDIEREALPSQLLVHGQRAFPLGVDNSFNCFLAAARYGHGRVVLGGHESLMLSEAMLPFVLNALHWLMGSQTGRIGLASEMKALKSMLPNGSFQWSETEHLTSDLSVFCCCSFTNIDPKKVEEFVAEGGGLLIGAEASLWGQRNPGSDCMTQYPNNIILKCFGLGIISKAVKNGSFPVPNPQVIDYHIRKALAQFESMIYGQKNILQERWLKKLVKDCSYMFQMTHQRVSIYDSVKEHALKLIQNEGFPSMSEEHPILNGSSQAFLLSLAYELFKSGVDVSQLLPPPSLLPPTESPMVIKISTDNRNSWVSTGLYLPEGQVAQITLPSDATNAKLKVLIGCHTDNISEAKTYYRPPVMTYIYHLNSSQKTISWLYGGLLYIIVPHKYNRDDVSVTISGAVSAPYFRIGKTTQEEWKNLTKYSEAPWGELATDNIILTIPKEYLKILRDPYPLLQLWDEMVQAVAKLAGVPFPLQRPERVVLDKQISLGYLHSGYPIMGNISIAEGIIDEILIRSHGIWGVMHELGHNQQKGRWHFRPHTTEALCNLWSIYVHETVLNIHRDQVHPSLKPELRKQRIKNHLDKGAPLSNWVVWTALETYLQLQEGFGWEPFIQTFADYQVLPDLPRDNESKMNLWVKKFSEVVQKNLAPFFEAWGWPVQNDVAESLAHLPEWQENPMKMYTPEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F5R9</accession>
    <name>A0A9J7F5R9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ragulator complex protein LAMTOR5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100774846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAMTOR5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027251761.1">
        <property type="nucleotide sequence ID" value="XM_027395960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F5R9"/>
    <dbReference type="GeneID" id="100774846"/>
    <dbReference type="KEGG" id="cge:100774846"/>
    <dbReference type="OrthoDB" id="76862at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000005">
        <property type="entry name" value="Ragulator complex protein LAMTOR5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024135">
        <property type="entry name" value="LAMTOR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13342">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13342:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16672">
        <property type="entry name" value="LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02092">
        <property type="entry name" value="HEPBVIRUSXIP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027251761.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20135" checksum="87BCF3658684B7E6" modified="2023-06-28" version="1">MSHSTLAMNLEYKNQVLGQEQRPWVPTADLAGKPNTSHQAGHVAAVLTFLKGRGRSAAMNLVPLETPSGHQARSNHVTQAFGEAGSVLLRDPGVGRIAGGMESTLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAAKLTSDPTDIPVVCLESDNGNIMIQKHDGITVAVHKMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F6D7</accession>
    <name>A0A9J7F6D7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lens fiber major intrinsic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aquaporin-0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Mip</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer; each monomer provides an independent water pore. Two homotetramers on opposing membranes can dimerize, forming a cell-cell junction. Interacts with CALM; the calcium-calmodulin/CALM complex interacts with the cytoplasmic domains of two aquaporins, leading to channel closure. Interacts with BFSP1 (via C-terminus); prevents calcium-dependent inhibition of the water channel activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027248550.1">
        <property type="nucleotide sequence ID" value="XM_027392749.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F6D7"/>
    <dbReference type="GeneID" id="100764175"/>
    <dbReference type="KEGG" id="cge:100764175"/>
    <dbReference type="CTD" id="4284"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000003">
        <property type="entry name" value="Lens fiber major intrinsic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF39">
        <property type="entry name" value="LENS FIBER MAJOR INTRINSIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02014">
        <property type="entry name" value="AQUAPORIN2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027248550.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="28211" checksum="D3BDAEBE9DC802AA" modified="2023-06-28" version="1">MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQTVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHAGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRMGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFSNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FCF2</accession>
    <name>A0A9J7FCF2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Toll-like receptor 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100755844</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027255149.1">
        <property type="nucleotide sequence ID" value="XM_027399348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FCF2"/>
    <dbReference type="GeneID" id="100755844"/>
    <dbReference type="KEGG" id="cge:100755844"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000832">
        <property type="entry name" value="Toll-like receptor 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001639">
        <property type="entry name" value="Toll-like receptor 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF545">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039923089" evidence="14">
        <location>
            <begin position="20"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="758"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027255149.1"/>
        </source>
    </evidence>
    <sequence length="910" mass="100843" checksum="D65FF05CD6E6E546" modified="2023-06-28" version="1">MGWHVLLPGLLLSLPLVTGWTTSKCLLTEGSQLPLVSRYFALCPVFQLSFLATCNSVTNLTETLAAVPQTVEGLCLSGSVSSLPPDAFSAFPGLKILGLNLHLTRLLPGALRGLGQLQKLSFLDGPFGKQSLFIPPDAFGDLISLQRLHISGPCLDKKTGIQLPRSLQRLDVVFSCLQDVGELAGMFPDLVQGSSSRDPWSLHMLDLSFNRGLKMARPGSLQGLQLETLNLDQTRLEASRVRALGLQKLNVLSAKLTAMAELPAEAVAHFELQELNVGNNKIGYISQEALASFHSLKTLHLQSTGLTKLPPGFLAAMPRLQRLNLAGNQLQSKTLCMNETGDVSGLMTLDLAGNGLSTLPPDTFSCLPHLRELLLQDNQLLSLERQLFQGLQQLETLNLDKNPLLNLGKNWLAALPALTTLSLLDTQLSLSPDPGFWESKSLRTLRLKLPSAPALTVLSLPMYLTSLELHGASGRKHWGLSPRVFPFLENLTIVGQGLRLEVQNASGVFPALQQLSLLQNSLEAFCSQDNPNIFPWQLPKLQTLKIWGAGSNFRPCLITGLPSLQELKLEALQSIIQPRSVQLEELVGELPQLRALQLSRTGLKSLSAAAFQRLGSLRVLVLDNEKDLVLHDSLREYSPQMPQYIYILQSNLACQCANAWMEPWVKQSTKTYIYMPNNKLCLAEEEGPAKHSLFSFLWDHCPQSLELKLFLASSSLVFLLITLPLLQEARNLWIPFLQALFRVWLQGRRGQGDEGKRFLFDVFVSHCRQDQGWVIEELLPTLEGFLPAGPGLRLCLPDRDFEPGKDVVENVVDSMVSSRVVLCVLSGQALCNPRCRLELHLATSLFLAAPFPPVLLLAFLEPISRHQLPSYHRLARLLRRGDYCLWPEEDERKAGFWAWLKSRLGQPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FIS1</accession>
    <name>A0A9J7FIS1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Prenylcysteine oxidase-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Pcyox1l</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027258585.1">
        <property type="nucleotide sequence ID" value="XM_027402784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FIS1"/>
    <dbReference type="GeneID" id="100758588"/>
    <dbReference type="KEGG" id="cge:100758588"/>
    <dbReference type="CTD" id="78991"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000081">
        <property type="entry name" value="prenylcysteine oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.660.20:FF:000003">
        <property type="entry name" value="Prenylcysteine oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF2">
        <property type="entry name" value="PRENYLCYSTEINE OXIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039947156" evidence="9">
        <location>
            <begin position="21"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="10">
        <location>
            <begin position="120"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027258585.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="54769" checksum="622CA552B50BE2BD" modified="2023-06-28" version="1">MARAAPLLAMLATLLTAAAAGGDAPPGKIAVIGAGIGGSAVAHFLQQHFGPRVQIVVYEKGAVGGRLATISVNKQNYESGAASFHSLSLHMQDFVKLLGLRQRREVVGRSAIFGGEHFVLEETDWYLLNLFRLWWHYGISFLRLQMWVEEVMEKFMRIYKYQAHGYAFSGVEELLYSLGEATFVNMTQRSVAESLLQVGVTQRFIDDVVSAVLRASYGQSASMPAFAGAMSLAGAQGNLWSVEGGNKLVCSGLLKLAKASVIHATVTSVTLHATEGKALYQVAYESDKGNSSEFYDIVVIATPLHLDNSSNNITFEGFTPPIDDIQDSFQPTVVSLVHGYLNSSYFGFPDPKLFPFANILTTDFPSFFCTLDNICPVNISASFRRKQPQEAAVWRVQSPKPLFRTELKTLFRSYYSVQTAEWQAHPLYGSRRSLPKFALHDQLFYLNALEWAASSVEMMAVAAKNVALLAYNRWYQDLDKIDQKDLIHKVKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FM40</accession>
    <name>A0A9J7FM40_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="7">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysophospholipase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Lysophospholipase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC100764608</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="ChEBI" id="CHEBI:78421"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41721"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="7"/>
    <dbReference type="RefSeq" id="XP_027263823.1">
        <property type="nucleotide sequence ID" value="XM_027408022.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FM40"/>
    <dbReference type="GeneID" id="100764608"/>
    <dbReference type="KEGG" id="cge:100764608"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF22">
        <property type="entry name" value="ACYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="25">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027263823.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24395" checksum="45362397EDD8BA6F" modified="2023-06-28" version="1">MSAPLRAVLPAAQKATSAVIFLHGLGDTGHGWADAFADIRSSHIKYICPHAPVMPVTLNMNMAMPSWFDIIGLSPDSHEDESGIKQAAESVKSLIDQEVKNGIPFNRIILGGFSQGGALSLYTALTTQQKLAGITALSCWLPLRASFPQSPINSTNRDISILQCHGDCDPLVPLMFGSLTVEKLKALVNPSNVTFKVYEGMMHSSCQQEMMDVKQFTDKLLPPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FPK0</accession>
    <name>A0A9J7FPK0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100752064</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027263210.1">
        <property type="nucleotide sequence ID" value="XM_027407409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FPK0"/>
    <dbReference type="GeneID" id="100752064"/>
    <dbReference type="KEGG" id="cge:100752064"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20665">
        <property type="entry name" value="CYP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000299">
        <property type="entry name" value="Cytochrome P450 2C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF384">
        <property type="entry name" value="CYTOCHROME P450 2C29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039934164" description="unspecific monooxygenase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027263210.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55561" checksum="DA63F7E3F67CA340" modified="2023-06-28" version="1">MDPVVVLVFILTCLVLLSFSRQSSERRNLPPGPTPLPFIGNFLQIDVKNIGRSLTNLSKVYGPVFTLYLGMRPTVVLHGYEAVKEALIDHGEEFAGRGSFPVAERFNKGLGIVFSNGSRWKETRRFTLMTLRNLGMGKRSIEDCVQEEAQCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQNRFDYKDKYFLDFLKKLNENSRILSSPWLQVCNNFPSLIDYCPGSHHTITKNINYIRSYLSEKIKEHQESLDVANPRDFIDYYLIKLKQSNHNQQSELSLENLATTVSDLFAAGTETTSTTLRYALLLLLKHPHVTAKVQEEIDQVVGRGRSPCMQDRSRMPYTDAMVHEVQRFIDLVPSNLPHAVTCDIKFRDYFIPKGTTVITSLTSVLLDSKEFPNPEVFDPGHFLDKDGNFKKSDYFMPFSIGKRMCAGEGLARMELFLFLTTILQNFKLKSLVHPKDIDTTPVLNGFGSLPPPYKLCFIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FTT6</accession>
    <name>A0A9J7FTT6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="14">PARP</shortName>
            <ecNumber evidence="14">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Parp14</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_027268564.1">
        <property type="nucleotide sequence ID" value="XM_027412763.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100758989"/>
    <dbReference type="KEGG" id="cge:100758989"/>
    <dbReference type="CTD" id="54625"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001961">
        <property type="term" value="P:positive regulation of cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060334">
        <property type="term" value="P:regulation of type II interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02903">
        <property type="entry name" value="Macro_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12300">
        <property type="entry name" value="RRM1_PAR14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000487">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000010">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057043">
        <property type="entry name" value="PARP14_KH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057045">
        <property type="entry name" value="PARP14_KH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057046">
        <property type="entry name" value="PARP14_KH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057047">
        <property type="entry name" value="PARP14_KH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057048">
        <property type="entry name" value="PARP14_KH_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057049">
        <property type="entry name" value="PARP14_KH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057051">
        <property type="entry name" value="PARP14_RPM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054596">
        <property type="entry name" value="PARP14_WWE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057050">
        <property type="entry name" value="RRM_PARP14_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF89">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23248">
        <property type="entry name" value="KH_PARP14_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23249">
        <property type="entry name" value="KH_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23251">
        <property type="entry name" value="KH_PARP14_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23252">
        <property type="entry name" value="KH_PARP14_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23253">
        <property type="entry name" value="KH_PARP14_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23254">
        <property type="entry name" value="KH_PARP14_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23222">
        <property type="entry name" value="RRM_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23245">
        <property type="entry name" value="RRM_PARP14_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22005">
        <property type="entry name" value="WWE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="19">
        <location>
            <begin position="777"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="19">
        <location>
            <begin position="991"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="19">
        <location>
            <begin position="1203"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="17">
        <location>
            <begin position="1509"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="18">
        <location>
            <begin position="1591"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1173"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1483"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027268564.1"/>
        </source>
    </evidence>
    <sequence length="1787" mass="200120" checksum="E8FEB4D910F9443D" modified="2023-06-28" version="1">MAESGPFPLLVEGSWGPKPPKTLINKLQMYFQSPKKSGGGECEVVQQPGSPACFLVLFSPEDVRQNVLEKENHELVWQGKGTFKLTVRLPEDPDKASVSKEAVPEKESKTKNDAAKTGFPSDRSEKMEDVPTECENISSMVAFENLSEKVSDVVLTFLVENISGFPSECFKVEVIRDFGVAVVTFQMPIDTKKFITDCISHHSNRQLQLVPRLLETTNVVRVENLPPGVDDFQLQLYFENPFNGGGRVAHVECFPEESSALVEFVDSKVLDTIMAKKHSFNKMPLSVFPYYPSLGTALYGEEKPLVKLPASFQESLGLPLWKFFQKNNHLIEEINDKMRCCHCELMWSEINGTLTIRPAATLASHRPSIKTWQRDASKALSAIRSKYEVKLFEVYSPVWDIIRHELRDDRILIEFDKDCLTLAGKSEDVQDIGQKIKELIDSTTEKVRKEEQSLKEKVAISPGKHFLLEHSGFLEDLSKDYPEMEIHYDAATQNLCFKGFHVDVYKVKCDIQEKVYSMSQKEVRVPSEVFMFLQQVNSQEFSKTLFEAQKILATYELKGTALFLTACSLRALAEAEKQVADALSYKLIEVEDKEVLTGNVWKKKIHPLQKRYNSTATIIIKNELTSGTPAEVIIAGCVREVNEIYDQLFEFLENNMKIERLFEVEPSLIIDYVKTDKKLFWPKIKKANVQASFKLEDEPKGILLTGSKSKVLECMNMVKQIQDSACIKRFQIDKPGAKHFFQDKASYYKSEIKRLYGCVIELQEDGEKEKGSLKEQKCHLQIDIAPGVTLIVQQGDLAQFAADVVVNASNENLKHIDGLAKALSNAAGPELQAECDRIVRSRGTVLTGNAVISKAGKLPCRHVIHAVGPRWKGDKAQECVSLLKKVVDRSLTLAEEYKCQSIAMPAISSGIFDFPLDQCVATIVSAIKDNFKRKSDRSTLKKIYLVDISAKVAGAFAEAVETAYKATISHAASPPSLKALELVPPGKIPEREDCLLVSQEGLRIRLVEEGVQHAKTDVIVNSIPSDLALNRGPLSQALLEKAGPGLQEELNQAGQGVAVNAGTILQTSGYNLNCHHVLHVVVPQWKAKNSASSVKIMKNIIRDCLKMAEEQSLQSIGFPAIGTGNLGFPKPEFAKLIISEVLKFSSRNLKTLQEVQFLLHPKDQDNIKAFSDEFDRRSNGNPSDHSPKAEDTQGYYGSLSSPTLGVHEMNIGPILFQVATGDITKEVADVIVNSTSNTFNLKSGVSKAILEGAGQNVEAECSVLAQQNKEYIVTVGGLLKCKSIIHVVGGNDVKRSVSCVLEESEQRNYTSICLPAIGTGSAQQDPDAVAKAIMDAIEEFIQKKAVRSVRKVKVVIFQPHILKIFYDNMEDREGSLPPPQTSMLSKIASIFGFSKNDPPKQNTLFLEKKIEQTVFQVCGADTDSVERTISWIQNLITDEQLSYTSHDECIRDFNESEYKKLNELQERLNITIDLDKKAPLITVEGISRDVVRARDEIEELIKSIRLAKEKESHADYVSTFVEWQYIDNNVTYSFDKMANMELEEARKAKSKNILVKINNHNFMVNLSTNTAIGPGRQSLTVQRLLKTEAEIPPNWSDMKQKNLLVVSLQPNDPEYNMVASKFNQTSTNFIIENIKRIQNPYLWSKYQANKKVMDEKNGHGRNENQLFHGTEASCILHVNSHGFNRSYAGKNATCYGQGTYFAVNASYSASDTYSKPDASGKKHMYYARVLTGNYTVGHSSLIVPPSRDPLNPTDLYDTVVDNDQNPSIFVVFYDNQTYPEYLITFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FYM8</accession>
    <name>A0A9J7FYM8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DDX54</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAD box protein 54</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Ddx54</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts in a hormone-dependent manner with nuclear receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027269938.1">
        <property type="nucleotide sequence ID" value="XM_027414137.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FYM8"/>
    <dbReference type="GeneID" id="100770376"/>
    <dbReference type="KEGG" id="cge:100770376"/>
    <dbReference type="CTD" id="79039"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000784">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="126"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="309"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="579"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="712"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027269938.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="98167" checksum="33F5888839E2E8F0" modified="2023-06-28" version="1">MAAGRRVGPGPRSRAAMAPWKKKGLRKRRTGASQARDSESEDGEFEIQAEDDARARKLGPSRALPSFPTSECISDVEPDTRELVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKARSAQTGARALILSPTRELALQTMKFTKELGKFTGLKTALILGGDKMEDQFAALHENPDIIIATPGRLMHVAVEMNLKLQSVEYVVFDEADRLFEMGFAEQLQEIIGRLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKLNEQLKTSFLLVREDTKAAVLLYLLRNVVRPQDQTVVFVATKHHAEYLMELLTAQGVSCAHIYSALDQTARKINLAKFTHNKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEVPYLLDLHLFLGRSITLAQPHEEPSGAVGRDGVLGRVPQTVVDDEDSGLQTALEASLDLRGLHRVADNAQQQYVRSRPAPSPESIKRAKELDLAGLGLHPLFSSRFEEGERQRLRLLDSVKSYRTRTTIFEINASCRDPSSQMMRAKRQRDQKAIDSFQQGRQERQESPADPVPQKELPQKEEGEEDMAESVEDVFTEVVGQKRSKPGPNRGAKRRREEARQRDQEFYVPYRPKDFDSERGLSIGGTAGAFEQQVAGAVLDLMGDEAQNMSRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESGRYISSSYKRDLYQKWKQKQKIDDRDSEDEGSFNQRGPGPRRGGKRGRSQGGQGASLPRAPSAPTGRMRSELKTKEQILKHRRQAQKQRFLQRGGLKQLSARNRRRAQELRQGAFGRGAPSRKGKMRKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G5R9</accession>
    <name>A0A9J7G5R9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100766707</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cell membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276966.1">
        <property type="nucleotide sequence ID" value="XM_027421165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G5R9"/>
    <dbReference type="GeneID" id="100766707"/>
    <dbReference type="KEGG" id="cge:100766707"/>
    <dbReference type="OrthoDB" id="9890226at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15945">
        <property type="entry name" value="7tmA_OR5C1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027276966.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35333" checksum="746F075AB020EE55" modified="2023-06-28" version="1">MHHINYTRPTEFIFIGFTDYLPFRFILFLVFLIVYTLTVVGNMGLITLVNIDIRLQTPMYHFLSNLSFLDISYSTAIAPKMLVNFLASRKSISFYGCAVQMFFFACFADAECLILAAMAYDRYAAICNPLLYSTLVSRRVCFSLVMLAYFSGSVTSLVHVSLTFMLPYCGSNIVNHFFCDIPPLLALSCADTYINELLLFALCGTIQMSTFMVILISYFYILITVLSIKSSGGRGKTFSTCASHLIAVTLFYGTLLFMYLRPTTSYSPDTDKVVALFYTVVFPMLNPIIYSFRNKDVKNAIKKLLEKKGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G7L9</accession>
    <name>A0A9J7G7L9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100771207</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276886.1">
        <property type="nucleotide sequence ID" value="XM_027421085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G7L9"/>
    <dbReference type="GeneID" id="100771207"/>
    <dbReference type="KEGG" id="cge:100771207"/>
    <dbReference type="OrthoDB" id="9579061at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276886.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35359" checksum="FB2DDB716C0842B0" modified="2023-06-28" version="1">MQNQSFVTEFILLGLSQNSKVEKILFVVFLLIYLATIWGNMIIVVTIIYSPTLLASPMYFFLIFLSLLDACTSSTVTPKMIVDFFYRRKTISFEWCMIQLFAIHFFTGIEVIVLSAMAYDRYVAICKPLHYTSIMTRRLCGILVAISWAGGFLHSTVQIIFTLQLPLCGPNIIDHYMCDLFPLLKLACTDTHIFVILVFANSGSISIIIFSILLVSYGVILYSLRAHSTEGRLKALSTCGSHITVVLLFFVPCFLIYARPTSAFSSEKNAFVFATIITPLLNPMVYTFRNKEIKNAIRIMWKRLIMVSNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G884</accession>
    <name>A0A9J7G884_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Prostaglandin-H2 D-isomerase</fullName>
            <ecNumber evidence="27">5.3.99.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Glutathione-independent PGD synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Lipocalin-type prostaglandin-D synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Prostaglandin-D2 synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">Ptgds</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
            <tissue evidence="36">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>prostaglandin H2 = prostaglandin D2</text>
            <dbReference type="Rhea" id="RHEA:10600"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57406"/>
            <dbReference type="EC" id="5.3.99.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 32">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.2" evidence="27"/>
    <dbReference type="RefSeq" id="XP_003515537.1">
        <property type="nucleotide sequence ID" value="XM_003515489.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278687.1">
        <property type="nucleotide sequence ID" value="XM_027422886.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G884"/>
    <dbReference type="GeneID" id="100762704"/>
    <dbReference type="KEGG" id="cge:100762704"/>
    <dbReference type="CTD" id="5730"/>
    <dbReference type="OMA" id="QIWNNDN"/>
    <dbReference type="OrthoDB" id="9048943at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004667">
        <property type="term" value="F:prostaglandin-D synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005501">
        <property type="term" value="F:retinoid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043303">
        <property type="term" value="P:mast cell degranulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19419">
        <property type="entry name" value="lipocalin_L-PGDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000010">
        <property type="entry name" value="Prostaglandin-H2 D-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF86">
        <property type="entry name" value="PROSTAGLANDIN-H2 D-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00179">
        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01254">
        <property type="entry name" value="PGNDSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0467">Mast cell degranulation</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="10" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0964">Secreted</keyword>
    <keyword evidence="15 33" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="33">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039907608" description="Prostaglandin-H2 D-isomerase" evidence="33">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="34">
        <location>
            <begin position="43"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00030654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00031917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00032350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="RuleBase" id="RU003695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_027278687.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21479" checksum="32EDA4DB100D87CD" modified="2023-06-28" version="1">MAALHMLWMGLVLLGLLGFPQTPAESKSYDSVQPNFQEDRFLGRWYSAGLASNSSWFREKKPVLLMCKTVVAPSTDGGLNLTSTFLRKNQCETKIMVLQPAGVPGQYNYNSPHWGSVHSVSVVETNYDEYALLFSRGTKGPGQDFRMTTLYSRTQTLKDELKEKFTAFSQAHGLTEEDIVFLPQPDKCIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GDD4</accession>
    <name>A0A9J7GDD4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myb-binding protein 1A isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Mybbp1a</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_016833015.1">
        <property type="nucleotide sequence ID" value="XM_016977526.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282622.1">
        <property type="nucleotide sequence ID" value="XM_027426821.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100758378"/>
    <dbReference type="KEGG" id="cge:100758378"/>
    <dbReference type="CTD" id="10514"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="698"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="797"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1173"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1206"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1236"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027282622.1"/>
        </source>
    </evidence>
    <sequence length="1347" mass="152439" checksum="2EE5F78BC433EFCF" modified="2023-06-28" version="1">MAEMKSPAKAESASPTETTQDERRGLLEHSREFLDFFWDIAKPEQETRLQATEKLLEYLRTRPSGSEMKYALKRLITGLGVGRETARPCYSLALAQLLQAFEDIPLCSILGQIQEKYNLQTVNKGMMRPALFANLFGVLALFQSGRLVKDQEALMKSVKLLKILSHHYNHLQGQPIKVLVDILSQVPESMFQEILPKILKGGDLNVILSSPKYLELFLLAQQRVPAKLESLMGSVDLFSEENIPSLVNVLKTAANSVRKEHKLPEVALDLLRLALKENKFTLFWKEVLEQRLLNKPCWSASYMCFRLLGASLPLLSEEQLRLVMRGDLIRHFGEHMVISKPQNLFKIIPEISSYVSTFLEGCQDDPKRQFAMMVAFTSITNQGLPVMPTFWRVTRLLSSEALQSYVTWLRDMFLQPDLDSLVDFSTANQKRAQDASFNVPERSVFRLRKWIIHRLVSLVEHLHLEKDDAVVEQVARFCFFHAFFKTKKATPQIPETKQHFSFPLDDRNRSVIIGAFFSLLQTLSMKSRQTPDLNECAKPWTYRLVQLADMLLNHSRNVTVVTPFTTQQRQAWDQMMSTLKELEARSSETRALAFQHLLLLVGLHLFKSPTESCDVLGDIQTCIKKSMEQNPRRSRSRAKASQEPAWVEVMVEILLSLLAQPSNLMRKVVRNVFGHICSHLTPRGLQLILAVLNPETNEDEDDNVVVTDDTNEKQLKRGEDEDSDSEDNKNSDSDVDSEDGAESEEEDRDKDVDPGFRQQLMEVLQAGNALGGVDSEDEEELGDEAMMALDQNLASLFAEQKLRIQARQEEKNKLQKEKQLRRDFQIRVLDLIEVLVTKQPEHPLILELLEPLLSIIQRSMRSKGSTKQEQDLLHKTARIFMHHLCRARHYCHEVGPCAEGLHAQVERLVQQAGSQADASVALYYFNASLYLLRVLKGNTAKRYEDGQNLPGAEPKDSELSHQAQTANCLDLDFVTRVYSAALESFLTKRNSPLTVPMFLSLFSRYPVICKNLLPVLVQHVSGPLRPRHQAQACLLLQKTLSARELRVCFEDPEWEQLIGQVLGKLTQTLQTLGDAQSKGEQQREFSTLELLNILFKTVNHEKLSVDLTSVLGLLQSKQQKLQQSLQQGNHSSGSNRLYDLYWQAMRMLGVQRPKSEKKNVKDVPSDSQSPISQKRKKKGFLPETKKRKKVKSEDTTPGKDATSGQEVVTAGATPAAAGEGQPPSTGKKKRKRVKANTPSQVNGTPVTKSPAPNNPTLSPSTPFKSPKLQKKKEKLSQVNGGTPVSPIEPEGKEHHQKALPTKEVLRKSPQSALPRKRARLSLVSRSPSLLQSVVKKRKVARRKMQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJG8</accession>
    <name>A0A9J7GJG8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G patch domain-containing protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Gpatch1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPATCH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027286079.1">
        <property type="nucleotide sequence ID" value="XM_027430278.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJG8"/>
    <dbReference type="GeneID" id="100757025"/>
    <dbReference type="KEGG" id="cge:100757025"/>
    <dbReference type="CTD" id="55094"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027286079.1"/>
        </source>
    </evidence>
    <sequence length="935" mass="103450" checksum="3F9BCEBAB6A164D9" modified="2023-06-28" version="1">MAAPDGDSDEDLVSYGTGLGPLEEGERPKKPVPLQDQTVRDEKGRYKRFHGAFSGGFSAGYFNTVGSKEGWTPSTFVSSRQNRADKSVLGPEDFMDEEDLSEFGIAPKAIVTTDDFASKTKDRIREKARQLAAAAAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGVGPRVKRKPRRQKPDPGVKIYGCALPPGGSEGSEDEDDDYLPNNVTFAPKDVMPVDFTPKDNVHGLAYKGLDPRQALFGRPGEHLNLFGGAPEGTSHLLEDVGLSKGRKLGISGQAFGVGALEDEDDDIYATETLSKYDTVLKDEEPGDGLYGWTAPKQYKSQKEPERDLRYVGKILEGFSLASKPLSSKKIYPPPQLPRDYRPVHYFRPMVAATSQNAHLLQVLSESSGKAGQDPGTHSRHQLNASKRGELLGEMPVQGSATSVLEFLSQKDRERIKETKQATDLKAAQAKARSLAQMASSSRAQASTPDLSSSSWHLAMGSGAATTRASNFKPFAKDPEKQRRYEEFLVLMKKGQKDALERCLDPGMTEWERSREREEFARAAQLYVASHSTLSSRFTHAKEEEDSDQVEVPRDQENDVSDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFNVPDPYPGSTVVGLPRVKRDKYSVFNFLTIPEPAPPPTAPAPSENALRPQPQHPGSDKSRKPSRWDTSKQEKKEDSISEFLSQARSKVGPPRQEPSTSGNKEKEQAPEPGPDKAADEGVDTQADGEGSRPSMDLFKAIFAGSSDEKSSSSEEEQEDSEDSQEHTEEASFNTSQEAAAGETSVTQAAEPEPCEPAVPFPIQKVQIDEREEFGPRLPPVFCPNTRQKLETPQKEKPKKSKEKHKTKKEHRRKKEKKKKHKKHKHKSRQKTKKPERSSSSESSDSSDSGSEEGGSADLSPQELLRRLKCLPLRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GPG7</accession>
    <name>A0A9J7GPG7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 30 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ccdc30</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035293156.1">
        <property type="nucleotide sequence ID" value="XM_035437265.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295552.1">
        <property type="nucleotide sequence ID" value="XM_035439661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GPG7"/>
    <dbReference type="GeneID" id="100770106"/>
    <dbReference type="KEGG" id="cge:100770106"/>
    <dbReference type="CTD" id="728621"/>
    <dbReference type="OMA" id="EREQHEC"/>
    <dbReference type="OrthoDB" id="10007527at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052825">
        <property type="entry name" value="CCD-Prefoldin_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031476">
        <property type="entry name" value="DUF4686"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15742">
        <property type="entry name" value="DUF4686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035295552.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="76347" checksum="231A707F380C9369" modified="2023-06-28" version="1">MCQEGLSRIALNSCSKQTECSLEERRMLGAAPGLVDSMLESRRHPGSSLQKEFPQHQNEDLTKDNQPQNCLFREVECMAQRLEEALEEIQRRAKEPQEKEKEQRKLDDALENARLEIEKLKNNLIKLKESDAADLLRAREHNQRLDQEILALRNRVRSLDSEKKVLGEMYLTSGEKVICQRQGEVQQLQQNLHRLQILCNSAEKELRYERGRSSDFKQHNSLLQEENIKIKIELKQAQEKLLDNARMHSSLTAEWKHCQQRVKELELEGLRQAQSIKSQQSLQEKLAQEKSKVADAQEKILDLQQKLEHAQQVCLSDACILHKKQLENEIKEAKSSEARLQQQCQEEQQRGLLLDQEINELQRQVRTLQDKENQQEATNSQQQEALHKQLENERRKCEESVKSNQELSEKLLRLQQEKDALWQEHGRFLEQLGEHVRNYKDKHHSHKVKLQKVKDHLTHELEVRNKRIKELEDETKKLEQKIEMEKAFQGQIMTQNDILLLEKRKLLEQVTNQEELICRNKSTISSIQSKAFLLDKENQQLQENCLRLKQHISLLERVVRSIQIHRVEETVISDNATFEILRKILPLQSSSFSGTGLVLPIENLQEMELYKPEGTTAIPKSPERFSCSQNSESGYINVTSLDTYNTQGDQKPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQ64</accession>
    <name>A0A9J7GQ64_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2 and S phase-expressed protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Gtse1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035294705.1">
        <property type="nucleotide sequence ID" value="XM_035438814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GQ64"/>
    <dbReference type="GeneID" id="100758123"/>
    <dbReference type="KEGG" id="cge:100758123"/>
    <dbReference type="CTD" id="51512"/>
    <dbReference type="OrthoDB" id="10072587at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026657">
        <property type="entry name" value="DDA3/GTSE-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032768">
        <property type="entry name" value="GTSE1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21584">
        <property type="entry name" value="DIFFERENTIAL DISPLAY AND ACTIVATED BY P53 DDA3 /G2 S PHASE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21584:SF10">
        <property type="entry name" value="G2 AND S PHASE-EXPRESSED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15259">
        <property type="entry name" value="GTSE1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G2 and S phase-expressed protein 1 N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035294705.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="79712" checksum="34B44E92A8E4EB83" modified="2023-06-28" version="1">MEGGDGCDVPSSIQARGVKMDTGSKKEDILLLEDEKFDFDLSLSSSSANEDDEVFFGPVGHKERCIAASLDLSGPVPGQTFTPASGSPCTWSPLTGEKFVEVYKEAHLLALQIESHSRREVAQAAKPQNPVNQGMERFVQDSQLKISLFEKEQKREKSPMSLKRETFCLPSSGGQPLLGEPQPLTSPAMLSSPIPTGPVQTQSNQALPCSSQSLPGESRTSQPPNQAGPQRRTTSKLQPPRALPVRGRHLHLATEKLKKEAPASLQRTKLLNEKGSQSDVPLNKPSTVTDAASRGSRLSKRSLPVPSKLGLKKTLLKPPAYTDSLTRRSSASGSASNLISSACVSPGAGRANSSDLSNIPTSGSRPLSNTSKLGKVGPAPLHQALKTAPTRASCRQTRRAGAAQTMAEQPKASNLTPLGQQPQTPEQRGPRLDPDTLTSSQLNKTGSIKRRDSYLNCKTEAVSTTTDPFKVPQFSVGFTICTPALQTHQLQPRTPASRVLSSTPVRRSLGPTQQGLPGSMRTPVSMRRMSTLPTPASRRLSGLPLMAPQSMPRALASPLCVPARRLSSEPRRRSTVRVEPTQESRSNANGGQGQGQSSDESSSAPSCVPQALDFSPNKSESPPSHGSTTEAAQGETEPHEDNTSPTEGLLLDIKLDQLTITPEAGGRDLADRPLIDFSNTPESNMALGPSSWPLIDLVMNTPDMGRNDVGKPPKAELGQLIDLGSPLIHLSPEADKENVDSPLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQ84</accession>
    <name>A0A9J7GQ84_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Collagen alpha-3(IV) chain isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Col4a3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">17A/GY</strain>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Collagen IV alpha 1 chain"/>
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        <property type="entry name" value="Collagen_IV_NC"/>
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        <property type="entry name" value="Collagen_IV_NC_sf"/>
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        <property type="entry name" value="Collagen_superfamily"/>
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    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1090">
        <property type="entry name" value="ALPHA2(IV)-LIKE COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="11"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="C-type lectin-like"/>
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        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7 13" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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            <begin position="1"/>
            <end position="28"/>
        </location>
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            <begin position="29"/>
            <end position="1671"/>
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            <begin position="1446"/>
            <end position="1670"/>
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            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="PROSITE" id="PS51403"/>
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            <dbReference type="Proteomes" id="UP001108280"/>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQA5</accession>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
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    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
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    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with collagen and binds to collagen fibrils.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.</text>
    </comment>
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        <property type="entry name" value="Chondroadherin like"/>
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        <property type="entry name" value="Chondroadherin-like a"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF101">
        <property type="entry name" value="LEUCINE-RICH ALPHA-2-GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039950171" description="Chondroadherin-like protein" evidence="14">
        <location>
            <begin position="17"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="16">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="16">
        <location>
            <begin position="655"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035296673.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="79489" checksum="BEF20B88D6AB4842" modified="2023-06-28" version="1">MLLLVLPLGPAWHVAAQRCPQTCVCDNSRRHVTCRHQNLTEVPNTIPELTQRLDLQGNMLKVIPPAAFRNLPYLTHLDLQHCQVELVAEGAFRGLGRLLLLNLASNRLSMLPQEALDGLGSLRRLELEGNMLEELRPGTFGALGSLTTLNLANNALVYLPSMAFQGLLRTRWLQLSHNALSVLAPEALVGLPALRRLSLHHNELQALPGAALSQARSLTRLELGHNPLTYAGEEDGLALPGLRELALDHGALQALGPRAFAHCPRLHTLDLRGNQLSTLPPLQGPGQLRRLRLQGNPLWCACHARPLLEWLVRARVRSDGACRGPRRLRGEALDALRPSDLRCPGDTAEDEDEERAAGPRVPPRSQNQEAARATPCPPACVCVGETRHSACDGRGLQVVPRGFPNDTQLLDLRRNHFPSVPRAAFTGLCHLVSLHLQHCGIAELEPGALTGLDHLVYLYLSDNQLSGLSAAALQGAPHLAYLYLEHNRFLRVPGAALRALPSLFSLHLQDNAVDRLAPGDLAGARALRCLYLSGNHISQVSAGALGPARELEKLHLDRNQLREVPTGALEGLPALTELQLSGNPFRALQDGAFQPVGRSLQQLFLNSSGLEQISPMAFSGLETGLRNLYLQKNQLQFLPALLRLSGLELIDLSGNPFHCDCHLLPLHRWLTGLNLRVGATCATPPSVRGQKVKAAATVFEACPGWTARKAKRTSTSRFSARRSLNRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GTF2</accession>
    <name>A0A9J7GTF2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100774343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035293320.1">
        <property type="nucleotide sequence ID" value="XM_035437429.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298021.1">
        <property type="nucleotide sequence ID" value="XM_035442130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GTF2"/>
    <dbReference type="GeneID" id="100774343"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035298021.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="58509" checksum="8092165AAA428E59" modified="2023-06-28" version="1">MVLAWLPVASAHPHRGRHWSSRSQICVIVNTALTLWSTEGSTVKTTAIEEVVNSRMTRTLTEIDSQEESSGHSLLLQSCRCSSQEFCPADIISTVEFNYSGDLLATGDKGGRVVIFQREQENKGRTHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRAEGYNLKDEDGRLRDPFRITALRVPILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPHQCNVLVYSSSKGTIRLCDMRSSALCDRHAKFFEEPEDPSSRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMEGRPVETHQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSAIMTGSYNNFFRMFDRNTRRDVTLEASRENSKPRACLKPRKVCTGGKRKKDEISVDSLDFNKKILHTAWHPMESIIAVAATNNLYIFQDKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GW33</accession>
    <name>A0A9J7GW33_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">T-lymphocyte activation antigen CD86 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Cd86</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035300015.1">
        <property type="nucleotide sequence ID" value="XM_035444124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GW33"/>
    <dbReference type="GeneID" id="100769382"/>
    <dbReference type="KEGG" id="cge:100769382"/>
    <dbReference type="CTD" id="942"/>
    <dbReference type="OrthoDB" id="5857426at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16087">
        <property type="entry name" value="IgV_CD86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000582">
        <property type="entry name" value="T-lymphocyte activation antigen CD86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037677">
        <property type="entry name" value="CD86_IgV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF2">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN CD86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039901231" evidence="12">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="13">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035300015.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31239" checksum="F4ED4196104E2775" modified="2023-06-28" version="1">MKLGVLFVMVFMLSDAVSMKTQAYFNRTAYLPCPFTKAQNISLSELVVFWQDHKKSVLYEHYLGKEKLDNVNAKYLGRTSFDGDNWTLGLHSVQIKDMGTYDCFIQKKTPKGSVILQQTETDLSVIANFSEPEIEFQNITRISGINLTCSSKEGYPKPTKMYILVTNSTNSTNEHSGDMEISQDNVTELFSVFISLSVPFPNGMSSVTTRCVLEIESMKIFSRPHNIEIKMESEGSEKLEKGFNLKHAETYKKANGGREDSKTRENMEKVALNSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GY63</accession>
    <name>A0A9J7GY63_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 63 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ccdc63</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_007625967.1">
        <property type="nucleotide sequence ID" value="XM_007627777.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300218.1">
        <property type="nucleotide sequence ID" value="XM_035444327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GY63"/>
    <dbReference type="GeneID" id="100774262"/>
    <dbReference type="KEGG" id="cge:100774262"/>
    <dbReference type="CTD" id="160762"/>
    <dbReference type="OrthoDB" id="6766775at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="111"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
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            <begin position="156"/>
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            <begin position="332"/>
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    </feature>
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        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035300218.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="60516" checksum="7AB63D65FE5A5FAC" modified="2023-06-28" version="1">MVESRKSFNFRNQSMMASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFMELRVLLQTKGDYEALITSMKVLLGELDDKIVQVERKISSQRQIFLKTQEANNPRKLQKQIHILETRLNLVTVHFDKMLTSNAQLRKEIEDLLFEKAAYDHVYQQLQRRLQIQQKTMNIAIEQSALAYEQRVEAMARMAAMKERQKKDISQYNLEIRELERLYAHETKLKSFLLVKLNDRTEFEEQAKKEAAAKSKKHGKKSKGESFESYEVAHLRLLKLAENGNLNQLTEDFLAKEEKNFARFTYVTELNNDMETMHKKTQRIQDDITNLRSQQQSSEQGTKNILRQMEEKLKKTTEDADAFESRYKEVSKTLEDLKNSVEKLFKKINCDATEILGKLGETGKITDSNLQQYFAIIEKKTNDLLILESFRRLQDAEGPDIDVPQAFVNPFWGGSALLKVMEPTKVMPPVFGSETFSDKLEEVDYPLDHSSLRQLVLENYLQKDRGKDPQDTLSEKGDELKPKKKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H003</accession>
    <name>A0A9J7H003_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC113835543 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC113835543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035299642.1">
        <property type="nucleotide sequence ID" value="XM_035443751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H003"/>
    <dbReference type="GeneID" id="113835543"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035299642.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23313" checksum="BF416B444ECD0881" modified="2023-06-28" version="1">MARTDRGLQVRAGRGPLARRALFRPDPQAGAAGLLLRLCAPGSPPLGHPGPRRVGSAAAVGEGRAAGAPGNMAARPSSAASRPPVPEMRLGREVAEEKRRRALNSSHLPTPQQPGPHALSPGASGHIDQKLNRTRDSQNLLRQPIFSSPQSSFPSRRESWELRARTRVRSQRSLRPERVRPAGPPLGAHSYAHPRTHTRTRGSTRTEDPAPAEFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H0H7</accession>
    <name>A0A9J7H0H7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Atp10b</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="RefSeq" id="XP_035303272.1">
        <property type="nucleotide sequence ID" value="XM_035447381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767948"/>
    <dbReference type="KEGG" id="cge:100767948"/>
    <dbReference type="CTD" id="23120"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000022">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF79">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE VB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1107"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1189"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1216"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1291"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1075"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="637"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1343"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1429"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1380"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1457"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="913"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1023"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1029"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1049"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1052"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1053"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1053"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035303272.1"/>
        </source>
    </evidence>
    <sequence length="1472" mass="165817" checksum="333A7CF64CCA1FF4" modified="2023-06-28" version="1">MTLSLDFSWLRWKWRTQNGFSQSPSESTPLLSPEMGQQSYNPTEQRVVYPNNGMCHQDWKKVSRRYPGNSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWIPSMEVFHREITMLPLAIVLFIIMVKDGIEDFKRYRFDREMNSASIQIYERIEQSYMQKRWQDVRVGDFVQMRCNEIVPADILLLFSSDPSGVCHLETANLDGETNLKQRRVVKGFSQQELQFQPEYFHSTIICERPNNHLSKFKGYMEHPDQTRTGFGSESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCIGLLFLMCLIGAVGHSVWNGTFQEHPPFDVPDADGNFLPLALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVYLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIVGSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQNSATMRSQGGAQPLKRSQSARVPIQSHFRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLETSDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPSSKALGTSLEKIQQLFQRLKLLSLSQSFSSTAPSDTDLGESLGPNMATTDSDEKDDASVCSGDCSTDGGYRSSTWEQGDILGSESGASLEEGLEAPALSLDGPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQGMCLTFDLLFTLGFDSVRKRMSVVVRHPLTGEIIVYTKGADSVIMDLLEDPACVSDIDVEKKLRRIQARTQKHLDLYARDGLRTLCIAKKVVNEEDFQRWASFRREAEASLDNREELLMETAQHLENHLTLLGATGIEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNIAYSCKLLDQTDTVYSINTENQETCESILNCALEDVKRFHEPQEAARKLCGCLIPSKMPSAMAPKVGLVIDGKTLNAIFQGKLENKFLELTQHCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQMIFFNLFFTSLPPIIFGILDKDVSAETLLALPELYKSGQNSECYNLPMFWISMADAFYQSLICFFIPYLTYRGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVLLGSFLMYFVVSLIYNATCVTCNSPTNPYWVMERQLSDPTFYLTCLLTPVVALLPRYFLLSLQGTYGKSLISKAQKIDKLPTDKRNLEIQNWRSKQRPAPASASASASASVPASGPAHAPPPCHIVPPTRQQDLGTSTPKNSSPPRKKHAEDWVLQSPRCSRELSRDDPCSGDTLAKLSSGECLLGPNRTMAPTAYTRGQKDVSRHSSKGSHRRSQSSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H6Q3</accession>
    <name>A0A9J7H6Q3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Collagen alpha-1(XXIV) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC103158657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035306579.1">
        <property type="nucleotide sequence ID" value="XM_035450688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="103158657"/>
    <dbReference type="KEGG" id="cge:103158657"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000008">
        <property type="entry name" value="collagen alpha-1(XXIV) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000003">
        <property type="entry name" value="Collagen alpha-1(XXVII) chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000085">
        <property type="entry name" value="collagen alpha-1(XXVII) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="10">
        <location>
            <begin position="1484"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1240"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1435"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035306579.1"/>
        </source>
    </evidence>
    <sequence length="1683" mass="171060" checksum="FCAFDC43725B1B64" modified="2023-06-28" version="1">MLSGIDILHQLGIGGKDVRHTSSATAVPSSSTPLPQRVHLTEFGVILKNNAYIEAPLANILPVSLRQPLTVLIGLQSHKVNNAFLFSIRNKNRLQLGVQLLPKKLVVHVGGKQSVVFNYSAHDERWHSLAITLRDRVVSMFVECGKRYFSGETTSEVQTFDSHSVFTLGSMNNNSVHFEGIVCQLDIIPSTEASADYCRSMKQQCPQADTSQAETSLPHTAVMPTRHPEHTPLPKGFGEAELPRKTFTDHTPVPKGFSEAELPRKTFSDGQNIPNIRNNNSDTVHKSQEHQISRPQVMSFHSGNVSAVTLENYRIEPKEFTTEEEMHLNLSVSHHHPREARIRTAGSDNFTQHNKEAAGLPVPKQAAPNVAHTNQEAMTNLKKAITANLHTNELMEMEQNLNNTLYRPSVDNHLELRKEGEFYPDATYPIENSYEAMPYDYYYYEDYRAMLDMEYMRGPKGDTGPPGPPGPVGIPGPSGKRGPRGIPGPHGNPGLPGLPGPKGAKGDPGLSPGQAAPGEKGDHGVLGLVGPPGLQGEKGPKGHPGLPGLRGEQGLSGPAGNIGSAGYPGRQGLTGPEGSPGPKGVRGFIGSPGEAGQLGPEGERGAPGIRGKKGLKGRQGFPGDFGDRGPAGLDGSPGLVGGIGPPGFPGIRGDVGPSGPIGPPGAPGPMGLSGNRGPSGIKGDKGEQGMTGEPGEPGYPGDKGTIGSPGPPGIRGKSGPSGQPGDPGPQGPSGPPGPEGFPGDIGIPGQNGPEGPKGHLGSRGPPGPPGLKGTQGEEGPIGPFGELGPRGKPGRKGHMGEPGPEGLKGEVGDQGDIGKIGETGSVGVPGEVGITGSIGEKGERGSPGPLGPQGEKGVMGYDGPPGAPGPMGPLGLPGLAGARGAPGSLGPKGQSGPRGPDGLPGDQGVHGAKGEKGNQGKRGSHGLTGKTGSPGERGAQGKPGLQGLPGSPGDRGPAGEPGARGLPGDAGLPGEMGVEGPPGTEGESGLQGEPGAKGDVGPTGSSGASGEPGSRGEPGGPGEEGLQGKDGLKGAPGGSGLPGEYGDKGEMGSPGTTGPWGAAGQMGLPGPDGIVGTPGQRGRPGKKGDKGQRGPMGEVGSRGSPGKVGESGPKGARGTRGAVGPLGLMGPDGEPGIPGYRGHQGQPGPLGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGEQGERGEHGEEGYKGHMGVPGLRGATGQQGPPGEPGDQGGQGLKGEKGAEGPKGKKGVPGPTGKPGIPGLPGLPGPKGLQGYHGVDGVSGDPGKPGPLGKRGLPGVTGSPGRTGLTGSPGPRGGKGSSGLPGSPGVPGPKGEQGLSGQPGIPGKRGQRGSQGDQGLHGEPGLKGQPGEHGDQGLRGFQGFPGPRGPEGDAGIVGIAGPKGPIGQRGNTGPLGREGIIGPTGGTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRRQMEINAAIQALIASNSALQMESFQNTEVTLINHSAEIFKTLNYLSSLLSSMKNPLGTRDNPARICRDLLSCEYKVSDGKYWIDPNLGCSSDAFEVFCNFSAGGQTCLSPVSVTKLEFGVGKVQMNFLHLLSSEATHIITVHCLSAPGWTSTQADGPGLPISFKGWNGQIFEENTLLEPKVLSDDCKIQDGSWHKAKFLFHTQNPDQLPVIEVQNLRHLRTERKHYVESSSVCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H7U3</accession>
    <name>A0A9J7H7U3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Zinc finger protein 800 isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18" type="primary">Znf800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16 17">17A/GY</strain>
            <tissue evidence="15 16 17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306735.1">
        <property type="nucleotide sequence ID" value="XM_035450844.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306736.1">
        <property type="nucleotide sequence ID" value="XM_035450845.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306737.1">
        <property type="nucleotide sequence ID" value="XM_035450846.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035306738.1">
        <property type="nucleotide sequence ID" value="XM_035450847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H7U3"/>
    <dbReference type="GeneID" id="100772711"/>
    <dbReference type="CTD" id="168850"/>
    <dbReference type="OrthoDB" id="10066279at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041697">
        <property type="entry name" value="Znf-C2H2_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039149">
        <property type="entry name" value="ZNF800"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16622">
        <property type="entry name" value="zf-C2H2_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16624">
        <property type="entry name" value="zf-C2H2_assoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="681"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035306735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035306736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035306737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035306738.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="81032" checksum="ED32B16A066ED2B6" modified="2023-06-28" version="1">MPLRDKYCQTDHHHHGCCEPVYALEPGDPPLLQQPLQTSKSGIQQIIECFRSGTKQLKHILLKDVDTIFECKLCRSLFRGLPNLITHKKFYCPPSLQMDDNLPDVNDKQSQAINDLLEAIYPRVDKREYIIKLEPIETNQNAVFQYISRTDNPAEVTESSSTPEQTEVQVQETSTEQPKAVPDTDTEVVEVVAAPPVEIVVDEAAPPTEEQPRESQADLETSDSSDLGHQLICCLCRKEFNSRRGVRRHIRKVHKKKMEELKKYIETQKTPNQTSKGRNKSVLVSLSRSCPVCCKSFATKANVRRHFDEVHRGLRRDSITPDKATKPGQPLFLDPASPKKSFKTRKQKSSKPEYNLTACKCLLCKRKYSSQIMLKRHMQIVHKITLSGANSKREKGPNNTANSSEIKVKVEPADSVESSSPSITHSPQNELKGTNHSNEKKNTPATQKNKVKQDSESPKSASPSAAGGQQKARKPKLSVGFDFKQLYCKLCKRQFTSKQNLTKHIELHTDGNNIYVKFYKCPLCTYETRRKRDVIRHITVVHKKSSRYLGKITASLEIRAIKKPIDFVLNKVAKRGPSRDEAKHNDSNPDGTSNSPSKKYEVADVGIEVKVTKNFSLHRCNKCGKAFAKKTYLEHHKKTHKANATNSPEGNKTKGRSTRSKALVCLAKPSPRSAAILRPPAGAVTTRQAASSCRAKLRGAARERQHPARALGKSAARRRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H949</accession>
    <name>A0A9J7H949_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC100750729</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_035304933.1">
        <property type="nucleotide sequence ID" value="XM_035449042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750729"/>
    <dbReference type="KEGG" id="cge:100750729"/>
    <dbReference type="OrthoDB" id="9396925at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14337">
        <property type="entry name" value="UBA_MARK_Par1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF3">
        <property type="entry name" value="GENE 10662-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="293"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="647"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035304933.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="79068" checksum="F89281F014D97663" modified="2023-06-28" version="1">MPPYQLTEDLIMEQGREACYSYEESFLTDYKMMMTVGHGHFSEVKLAFHVPTVTCVSVKVLRMKHASLVANEVSIMKSLQHPNIIKLFHVVQSRDTTYLVMEHASQGDLRHILELGSLQESEEXRLFTHILLAMQYCHENHIAHRDIKANNILLDCRGNAKLCDFGLATKVTQGQKLRDIWGILLYCAPEIFVEKAYDGCAVDIWSLGVLLFLMVVGLFTFQTISSEGVRCQIMAANFRIPEHVSIDIFNVIVEMLMINPDRRPTIDQIMRHPMTRDSKAHSQPMSTQKSPGTVSPGIVSTMTVMGYKSEEIIDSLRDQNYNQVMATYLILQHQSPGGDCGHHHVIPMQPGHVFDLADHHTFSVPLRRATEPAILNFTLPSKPQEKEDKKMPGRVDTITQEEDINEEVNITQEEAMNEKDTITEERTITQEKAITEKVTITQEEDITKQATITQEVSVTKGVTITKEEAITHEPTIILEEDMAREVTMTLEDTRTKEVTMADGVSMTQTESITEKETVIKHEDIIQETTITLEVTMAQLATLTQESTITQEEAITHGQPEDAGPASSGKRRCPSWKRVKKIMVNCLRHLFCCLLSAKRRQDSCKTLAPKKRDLAVTHRTSAKFLDLNNSALLICFLLRLVADGTRSGSLRLPDLHPRRRRALSQAGPPRRGAPPACPHGTGELQVGRPEGKRQVGWPEGKSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HBC9</accession>
    <name>A0A9J7HBC9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neuroligin-1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Nlgn1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306945.1">
        <property type="nucleotide sequence ID" value="XM_035451054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HBC9"/>
    <dbReference type="GeneID" id="100761653"/>
    <dbReference type="KEGG" id="cge:100761653"/>
    <dbReference type="CTD" id="22871"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031644">
        <property type="term" value="P:regulation of nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000001">
        <property type="entry name" value="Neuroligin 3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="15">
        <location>
            <begin position="52"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="627"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035306945.1"/>
        </source>
    </evidence>
    <sequence length="823" mass="92040" checksum="2C21D585163F94A5" modified="2023-06-28" version="1">MALPRCMWPNYVWRAMMACVVHRGLGAPLALCLLGCFLQTVHVLSQKLDDVDPLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTATNDLTHAPEEEIMSLQMKHTDLEHECESIHPHEVVLRTSCPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J855</accession>
    <name>A0A9J7J855_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Death domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Dthd1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027246518.1">
        <property type="nucleotide sequence ID" value="XM_027390717.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J855"/>
    <dbReference type="GeneID" id="100751886"/>
    <dbReference type="KEGG" id="cge:100751886"/>
    <dbReference type="CTD" id="401124"/>
    <dbReference type="OrthoDB" id="6118651at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08779">
        <property type="entry name" value="Death_PIDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28336">
        <property type="entry name" value="BA1-643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28336:SF4">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZU5" evidence="2">
        <location>
            <begin position="426"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="817"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027246518.1"/>
        </source>
    </evidence>
    <sequence length="901" mass="101693" checksum="65C186B3EDC1830B" modified="2023-06-28" version="1">MDTEDMGIDKLGQILKQIWRQNQMLKQALLGDNLCEMAGRATWIATVIFLGQGLNEALHQLLEHTVGIFQSTCQQLYIRLDKDNQCIWRQEIIAFTDCLMKVNEHLGNTAMLLREEEKEMCNLCSMHEDRTPQHTISAIQDTKATDIAPSKELNVMETATISPTNTGESHYTNQVQLKENETQIYSELGGKENNASLSGNVIGQEESQSTVFPDNAENKDEKQIEHMTAENINGNKEDIHDVIQTTAGETREISESRREEITTSPEAWDVSSKDVNSLHNESESLKQKNNIMEKEYLDELSDGTDPQVSCYITAPSNVLQQLDCQIVNSKSSFIVSDSEELVSNVITVECSDKEKKIPFPICIAIPFKASYKGNYRDIMVKMSDTNFQSSYLTPNSLEGIRGSYKGTCAAVNVYKLGMFSVVSCLKKQSFTVTKKGLTLKSSVDARVSFSYPAGVFSSPVLVQLKIQPVDPSLVSYLKAHQDSSYLVQSTSPLIHTQHPSTHSFQKPVTVFLPCSPLPESEKDHRRPESATMHRSLPTTSYFSRTKSASIRKPGNSACETLKLLGFRSRDGGWFGIDDIVVRTVQNGLVSFELGEHLERFIVLQLSSTVDNSHLVSFVKSLEEASLSTTACIVLSHQKDNPHKVVILVVPSKELNLALKNLRSEGFGGLPESSRHFQVREGEQLLLRFTGNIFGSSNGKDYGKDYKLIFHLQRKPRLELHIKEVDEFGNYSCPHYKGTIVVYKVPREKIVPNSDQSLHENLYQLPVCKLPLKLPKHEKVINRPQSTKRVSTDPLEALWDNLLHWLAEELSEEGVEVLTSSLPLRRSTVQLIKLKHPDDLTEQINELLCSWKRSLPTSMDKIRLLTRHLRKLGRSDLAEELKFKWEHKVFTEPQPWFDVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J959</accession>
    <name>A0A9J7J959_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">GD1 alpha synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">GalNAc alpha-2,6-sialyltransferase V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">ST6GalNAc V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Sialyltransferase 7E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">St6galnac5</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
            <tissue evidence="27">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acyl-sphing-4-enine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)]-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acyl-sphing-4-enine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:88073"/>
            <dbReference type="ChEBI" id="CHEBI:88079"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:78569"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41969"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027250980.1">
        <property type="nucleotide sequence ID" value="XM_027395179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J959"/>
    <dbReference type="GeneID" id="100759381"/>
    <dbReference type="KEGG" id="cge:100759381"/>
    <dbReference type="CTD" id="81849"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001574">
        <property type="term" value="P:ganglioside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23976">
        <property type="entry name" value="GT29_ST6GALNAC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000011">
        <property type="entry name" value="ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906:SF5">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="25" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039890678" description="Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5" evidence="25">
        <location>
            <begin position="22"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="87"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00077803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027250980.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37328" checksum="C7784C894D3D88FD" modified="2023-06-28" version="1">MKTLMHHGLAVCLVLTTMCTSLLLVYSSLGSQKERPLQQQQQATASSAEPVESSPQLRRTAPAGPRQLDGYLGVADHKPLKMHCKDCALVTSSGHLLGSQQGPQIDQTECVIRMNDAPTRGYGPDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLQLLSQVLPRLKAFMTTRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRIDVYGMVPPDFCRDPKRPSVPYHYYETSGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPHWKPESPSVNHAEDKPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J9C4</accession>
    <name>A0A9J7J9C4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">F-box only protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Fbxo7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. Interacts (via the N-terminal Ubl domain) with PRKN. Interacts (via N-terminal region) with PINK1. Interacts with PSMF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027248286.1">
        <property type="nucleotide sequence ID" value="XM_027392485.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J9C4"/>
    <dbReference type="GeneID" id="100753632"/>
    <dbReference type="KEGG" id="cge:100753632"/>
    <dbReference type="CTD" id="25793"/>
    <dbReference type="OrthoDB" id="101791at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22087">
        <property type="entry name" value="F-box_FBXO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000010">
        <property type="entry name" value="F-box only protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.30:FF:000001">
        <property type="entry name" value="F-box only protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047118">
        <property type="entry name" value="Fbxo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15537">
        <property type="entry name" value="F-BOX ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15537:SF2">
        <property type="entry name" value="F-BOX ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="13">
        <location>
            <begin position="361"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="493"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027248286.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="61068" checksum="7B0C7C4882AE0004" modified="2023-06-28" version="1">MPPRRRPGATGFRFLLRFGSRGRQRLAVRLAAMRLRVRLQKRTQPLEVPETEPTLGQLRAHLSQVLLPTWGFSSDTRFAITLNNKDALTGDEETLASYGIVSGDLICLVLEDDLPAPNLPSSTDSEHSSLQNNDQPSLAASSHQASIPDEQWSDSSQGQATQFDAWNDDSMEGPSQNVEAESIQEAMGMEEDSCCHPLEPMLCSETEDGQVPHSLETLYQSAGCSSISDALIVLVHLLMLESGYIPQGTEAKAVSMPEKWKSSGVYKLHYTHPLCEGGTAVLTCVPLENLIIINATIKIDGGIKNVKSVQLQPRSYVCGVEPGESAVKVYKDLKKLSRLFKDQLVYPLLAFTRQVLNLPDVFGLVVLPLELKLRIFRLLDVHSVLALSAVCHDLLIASNDPLLWRCLYLRDFQDGAVRGPDTDWKELYRKRHIQRKEAQRMRHAMFLTSPPHSIPFRPIPVYTRASLLTSLLPPGIIGGEYDVRPILPNVGDPVNPLVPRPGETPPLRPRFDPMVPLPGPNPLLPGRGGPNNRFPLRPGRGRPADSRLPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JBD4</accession>
    <name>A0A9J7JBD4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100769096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APEX1. Interacts with FMR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027260171.1">
        <property type="nucleotide sequence ID" value="XM_027404370.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100769096"/>
    <dbReference type="KEGG" id="cge:100769096"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027260171.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34059" checksum="F5E7287784E49E12" modified="2023-06-28" version="1">MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSQQMQQIRMSLRGKAVVLMGKNTTMRKAIXGHLENNPALEKLLPHIRGNVGFEFTKEDLTEIRDMMLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLRKTGDKGGASEATLLDTLNISRFSCGLIIQQVFDNGSIVNPEVLDITEQTLHSRFLEGVRNVASGCLQIGYPTVASVPHSIINGYKRVLALSVETESTFPLAEKVHAFLADPSAFAAAAPVAAATTAAPAAAAAPAKAEAREESEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JD88</accession>
    <name>A0A9J7JD88_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Keratin, type II cytoskeletal 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Krt74</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027251837.1">
        <property type="nucleotide sequence ID" value="XM_027396036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JD88"/>
    <dbReference type="GeneID" id="100754923"/>
    <dbReference type="KEGG" id="cge:100754923"/>
    <dbReference type="CTD" id="121391"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF5">
        <property type="entry name" value="KERATIN, TYPE II CYTOSKELETAL 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="140"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="209"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="351"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027251837.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="58687" checksum="FE525E48BBEE7176" modified="2023-06-28" version="1">MSRQLNFRSGGDKGNFSVFSAVVPRRPLGSMASCQATGYRVGAGFSSRSLYSLGGNRHISFDVAGGSARATELRFGHGSGYGGTRTSGFASSMFGIVDTGPTCPFMCLPGGIHHVIVNKSLLAPLNVELDPEIQKVRAQEREQIKALNDKFASFIDKVRFLEQQNQVLNTKWELLQQLNLNSCKGSLEPVYEAHISSLRKKLEMLSGDRVRLDSELRNMRDMVEDYKKRYEVEITRRTAAENEFVLLKKDADAAYMVKVELQAKVDSLEKDIKFLKCLYDAEIDQLQTHVSDTSVILSMDNNRDLDLDSIIAEVRAHYEDIALKSKAEAEALYQTKIQELQLAAGCQGDNLKHTRNEMLELNRLIQRIRRDIANVKKQCSNLETAIADAEQRGDCALKDARAKLDELEGALQQAKEELARMMREYQELMGLKLSLDIEIATYRKLLEGEECRMSGENPSSVSISVISSSYGSYGYHPSSMSSDFGAGNATGSPSTTRNSQTKTRGARATELRNSQNKSTAVGSPAKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JH75</accession>
    <name>A0A9J7JH75_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Canalicular multispecific organic anion transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">Abcc2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82961"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:60129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19121"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19122"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027240278.1">
        <property type="nucleotide sequence ID" value="XM_027384477.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263059.1">
        <property type="nucleotide sequence ID" value="XM_027407258.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100689220"/>
    <dbReference type="KEGG" id="cge:100689220"/>
    <dbReference type="CTD" id="1244"/>
    <dbReference type="OMA" id="RRRYILW"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000007">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
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        <property type="entry name" value="MRP"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF176">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="30"/>
            <end position="51"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="63"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="98"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="461"/>
            <end position="479"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="544"/>
            <end position="567"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="973"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1098"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1206"/>
            <end position="1228"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="604"/>
        </location>
    </feature>
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        <location>
            <begin position="636"/>
            <end position="860"/>
        </location>
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        <location>
            <begin position="979"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="1299"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047576"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048007"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
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    </evidence>
    <sequence length="1544" mass="173482" checksum="6D525234D2C6FD39" modified="2023-06-28" version="1">MEEFCNSTFWNSSFLERQEADLPLCFEQTVLVWIPLGFLWLLAPWQLFSVYRSKTKKSSITKFYIAKQVLVVLLLIVAAIDLALALTEDSGQDTIPPVRYTNPILYICTWLLVLVIQHSRQRCIQKNSWFLSIFWVLSILCSTFQFQTLIRVLLQDSKSNLAYSCLFFVSYGFQIIILILSTLSEKSDPSHNPSSTASFLSSITFSWYDSIVLKGYKHPLTLDDIWDVDEGFKTKSIASKFEEFMTKDLQKAKQAFQRRRQKKLQQNPEATLHGLNKNQSQSQDVLVLEEAKKKKKKSGTTKDFPKSWLIKSLFKTFHVVILKSFILKLIHDILMFLSPQLLKFLIAFVSNPDTYTWLGYVSAILIFVVTLIQSFCLQYYFQFCFVLGMTVRTTVLSSVYKKALSLSNLARRQYTIGETVNLMSVDAQKLVEVTNYMHLVWSSVLQIALSIFFLWRELGPSVLAGVGVMVLLIPVNGVLATKNRKIQVQNMKYKDKRLKIMNEILSGIKILKYFAWEPSFRDQVYGLRKKELKNLLKYGQLQTVMIFLLQLTPILVSVITFTVYVLVDSNNILDAEKAFTSITLFNVLRFPLTMLPMVTSSILQASVSIDRIEKYLGGDDLDTSSIHHVGNFDKAVQFSEASFTWDPDMDPAIRDVSLDIKPGQLVAVVGTVGSGKSSLIAAMLGEMETVHGHITIKGTTAYVPQQSWIQNGTIKDNIIFGSEFNENKYQQVLEACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARATYQDSDIYILDDPLSAVDAHVGKHIFNKVIGPNGLLNGKTRILVTHSIHFLPQVDEIIVLGNGTVLEKGSYQNLLSKKGVFAKNLKTFVKHSGPEGEATVNDDSEEDDDDCGLIPTVEEIPEDAASLTMKRENSLRRTLSRSSRSSGRHVKSLKDSLRVKNANALKEKEELVKGQKLIKKEFVETGKVKFSIYLKYLQSVGWWSIAFVIFSYGLNSVAFIGSNLWLSAWTSDSQNFNSTNYPTSQRDMRIGVFGALGLAQGVFVFIASIWSVYACNYSSKTLHKQLLTNILRAPMSFFDTTPTGRIVNRFSGDISTVDDILPQTLRSWLMCFFGIISTLVMICMATPIFAVIIIPLAIIYVSVQVFYVATSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLSRSEGLIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDTVGFVLSNALNITQTLNWLVRMTSEAETNIVAVERINEYINVENEAPWVTDKRPPADWPSKGEIRFNNYQVRYRPELDLVLKGITCHIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGVDIASVGLHDLRGKLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWKALELAHLKSFVDGLQLGLYHEVTEGGDNLSIGQRQLLCLGRALLLKSKILILDEATAAVDLGTDSLIQTTIRNEFSNCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELMSKTGPFYLMAKEAGIETANNTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JKK9</accession>
    <name>A0A9J7JKK9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100773361</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027268030.1">
        <property type="nucleotide sequence ID" value="XM_027412229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JKK9"/>
    <dbReference type="GeneID" id="100773361"/>
    <dbReference type="KEGG" id="cge:100773361"/>
    <dbReference type="OrthoDB" id="9591484at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15405">
        <property type="entry name" value="7tmA_OR8B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="47"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027268030.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35926" checksum="DD30B737629489EF" modified="2023-06-28" version="1">MRVLTQMTMENDSSVSEFILMGLTDQAELRLPLFVLFLVNYTATVIGNLSLMNLIYLNSNLHTPMYFFIFNLSFIDFCYSLVFTPKMLMSFVLEKNTISFRGCMTQLFFFLFFVNSESYVLTAMAYDRYVAICQPLLYKVVMSPKICCLLIFVSYLMGFACAMVHTGCMIRLRFCDSNIINHYMCDIFPLLQLSCSSTYVNELMSSVVVGTAIIVCCLIIFISYAMILFNIIHMSSGKAWSKALGTCGSHIITVSLFYGSGLLAYVKPSSTETVAQGKFFSVFYTLLVPMLNPLIYSLRNKDVMLAVKKTWKKFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JKM0</accession>
    <name>A0A9J7JKM0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100774708</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511470.1">
        <property type="nucleotide sequence ID" value="XM_003511422.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268063.1">
        <property type="nucleotide sequence ID" value="XM_027412262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JKM0"/>
    <dbReference type="GeneID" id="100774708"/>
    <dbReference type="KEGG" id="cge:100774708"/>
    <dbReference type="OMA" id="LSPRICT"/>
    <dbReference type="OrthoDB" id="9831875at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15405">
        <property type="entry name" value="7tmA_OR8B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000646">
        <property type="entry name" value="Olfactory receptor 887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:001035">
        <property type="entry name" value="Putative olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="47"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027268063.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35908" checksum="C051C1C73DF7E192" modified="2023-06-28" version="1">MKIYRRMTDGNYTLVTEFILEGLTNRPELQMPLFFLFLGIYMVTIVANLGLITLISLNSHLHTPMYYFLFNLSFVDICYSSVFTPKMLMNFVVEKNTISYTGCLTQLYFFCFFVITECYILTAMAYDRYVAICKPLLYNVILSPRICAVFVLGAYVMGCWGSLAHTLCMARLTFCDANLVNHYLCDILPVLQLSCTSTYDNEVVVFVLVGMNIVVSTSTTFISYGFIIANILRISSTQGRAKAFNTCSSHIMTVSLFFGAAAFMYMQPSDVESMDKGKVASVFYTNVGPMLNPLIYSLRNKDVKLALKKTLKRKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JRH1</accession>
    <name>A0A9J7JRH1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100761506</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276841.1">
        <property type="nucleotide sequence ID" value="XM_027421040.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JRH1"/>
    <dbReference type="GeneID" id="100761506"/>
    <dbReference type="KEGG" id="cge:100761506"/>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276841.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34190" checksum="985F38DDA7B2AE60" modified="2023-06-28" version="1">MANENNVTELIFSGLFQDAEVQKVCFVLFLPVYLATVLGNGLIVVTVHISKSLCSPMYFFLSSLSLVEICYSSTIVPKFITDLLEKVKTISLKGCLAQIFFSHFFGVVEVILLVVMAYDRYVAICKPLHYMNIMSHQVCHMLVAGSWLGGLIHSIIQILITIPLPFCGPNVIDHYFCDLQPLFKLACTDTFMEGVIVMVNSGLISIVSLLILMFSYVIILVNLRNHSAEGRRKALSTCASHITVVILFFGPGAFIYMRPSSTFTVDKLVAVFYTVITPMLNPIVYTLRNAEMKNAIRKFWSQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JS44</accession>
    <name>A0A9J7JS44_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="16">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Ptdss1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline</text>
            <dbReference type="Rhea" id="RHEA:45088"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:45089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:27607"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="16"/>
    <dbReference type="RefSeq" id="XP_027287339.1">
        <property type="nucleotide sequence ID" value="XM_027431538.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JS44"/>
    <dbReference type="GeneID" id="100762075"/>
    <dbReference type="KEGG" id="cge:100762075"/>
    <dbReference type="CTD" id="9791"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF15">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027287339.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="55601" checksum="0EE9F677AB813C36" modified="2023-06-28" version="1">MASCVGSRTLSKDDVNYRMHFRMINEQQVEDITIDFFYRPHTITLLSFTIVSLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADIMEYAVNCHVITWERIVSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGVYLFMIIWQLTELNTFFLKHIFVFQASHPLSWCRILFIGCITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVVFWLLCVAFTTFLCLYGMVWYAEHYGHREKTYSECEDGTYSPEISWHHGKGSKGSEDSPPKHSSNNESHSSRRRNRHSKSKVTNGVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUX1</accession>
    <name>A0A9J7JUX1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100757423</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276868.1">
        <property type="nucleotide sequence ID" value="XM_027421067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757423"/>
    <dbReference type="KEGG" id="cge:100757423"/>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276868.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33069" checksum="7EB73669D59B8302" modified="2023-06-28" version="1">MGQHNNVTEFVLLGLTQDPPGQNALFVMFLLIYIVTMVGNLLIVVTVIVSPSLGTLIYFFLATLSLMDAVYSTAISPKLIADLLHDKKTISFTACMSQLFIEHLFGGVDIVILVAMAYDRYVAICKPLHYLIIMNQRVCILFFLMAWAGGFAHGMIQVLVVCKLPFCGPNIIDHFACDIYPXLVLACTDTYSIGLSAIVNNGVMCIVIFILLLLYYGIILRSLKNHSQDGRSKALFTCSTHIIVFFLFFVPCIFMYVRPVSSFPVDKSITVFYTVVTPMLNPLIYTLRNSEMKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JW72</accession>
    <name>A0A9J7JW72_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Beta-1,3-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.222</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Rfng</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70511"/>
            <dbReference type="Rhea" id="RHEA-COMP:17919"/>
            <dbReference type="Rhea" id="RHEA-COMP:17920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="ChEBI" id="CHEBI:189633"/>
            <dbReference type="EC" id="2.4.1.222"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70531"/>
            <dbReference type="Rhea" id="RHEA-COMP:17922"/>
            <dbReference type="Rhea" id="RHEA-COMP:17923"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="ChEBI" id="CHEBI:189634"/>
            <dbReference type="EC" id="2.4.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 21">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.222" evidence="18"/>
    <dbReference type="RefSeq" id="XP_027281154.1">
        <property type="nucleotide sequence ID" value="XM_027425353.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100771257"/>
    <dbReference type="KEGG" id="cge:100771257"/>
    <dbReference type="CTD" id="5986"/>
    <dbReference type="OrthoDB" id="8959630at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033829">
        <property type="term" value="F:O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000003">
        <property type="entry name" value="Beta-1,3-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017374">
        <property type="entry name" value="Fringe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038073">
        <property type="entry name" value="B-acetylgalactosaminyltfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18 21" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039938064" description="Beta-1,3-N-acetylglucosaminyltransferase" evidence="22">
        <location>
            <begin position="34"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="23">
        <location>
            <begin position="52"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038073-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038073-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038073-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027281154.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36987" checksum="0636D6280B98D21D" modified="2023-06-28" version="1">MSRARGLLCRACLALAAVLAVLXLLPLPLPARAPAPDPARIPTPALPLGVSRLQPDDVFIAVKTTRKNHGPRLRLLLRTWISRALGRCAPRPTFIFTDGDDRELQMLAGGRMINTNCSAVRTRQALCCKMSVEYDKFIESGRKWFCHVDDDNYVNPESLLHLLSTFSSNQDIYLGRPSLDHPIEATERVQGGRTSNTVKFWFATGGAGFCLSRGLALKMSPWASLGSFMSTAERVRLPDDCTVGYIVEGLLGARLLHSTLFHSHLENLQRLPSDAVLQQVTLSYGGPENPRNVVNVAGSFSIQQDPTRFQSVHCLLYPDTHWCPVKNRGEVAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JWQ8</accession>
    <name>A0A9J7JWQ8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC113836993</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC113836993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027284463.1">
        <property type="nucleotide sequence ID" value="XM_027428662.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JWQ8"/>
    <dbReference type="GeneID" id="113836993"/>
    <dbReference type="KEGG" id="cge:113836993"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027284463.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="30807" checksum="7DC5D7D37D4BB10C" modified="2023-06-28" version="1">MMAGKHIVEDQIEEEYSLFGGSDKLKPLRDTLMGGLYGDHLKTPGSEEGFATQRDEGKYQEGPEEHTDTCNARRFWGEGSSPVAAPDPWFSLAGFYAFGISQTLMNKTSWPIRKAPCVSCWSTERLPEAFPCLNISSCLVCLWTCGNTSSCQEVQSQYPVARAASAFSCLKGFQPPDNSGSPAVAVDTLSHCPQEGGRRAGANSTRAMGRGHQSGSPSGQASGSSQWGSLPPPSPAPQPLPPSPTPDVELQSHCPNISVPQARACRHRPCARPRPHPRLRLHLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K0J8</accession>
    <name>A0A9J7K0J8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase KCMF1</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Kcmf1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of the SIFI complex, composed of KCMF1, UBR4 and calmodulin (CALM1, CALM2 or CALM3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KCMF1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="RefSeq" id="XP_027285262.1">
        <property type="nucleotide sequence ID" value="XM_027429461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K0J8"/>
    <dbReference type="GeneID" id="100753827"/>
    <dbReference type="KEGG" id="cge:100753827"/>
    <dbReference type="CTD" id="56888"/>
    <dbReference type="OrthoDB" id="7873042at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02338">
        <property type="entry name" value="ZZ_PCMF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="21">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00063645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027285262.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="41797" checksum="DDDA59A008E25D1E" modified="2023-06-28" version="1">MSRHEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQDHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSSREAMDPIAELLSQLSGVRRSAGGQLNSSGPSASQLQQLQMQLQLERQHAQAARQQLETARNASRRTNTSSVTTTITQSTATANTANTDSSQQALHNSQFLLTRLNDPKMSEAERQSMESERADRSLFVQELLLSTLVREESSSSDEDERGEMADFGAMGCVDIMPLDVALENLNLKESNKGNEPPPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K115</accession>
    <name>A0A9J7K115_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apoptosis facilitator Bcl-2-like protein 14 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Bcl2l14</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304373.1">
        <property type="nucleotide sequence ID" value="XM_035448482.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310995.1">
        <property type="nucleotide sequence ID" value="XM_035455104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K115"/>
    <dbReference type="GeneID" id="100774179"/>
    <dbReference type="KEGG" id="cge:100774179"/>
    <dbReference type="CTD" id="79370"/>
    <dbReference type="OrthoDB" id="9948726at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001236">
        <property type="term" value="P:regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14965:SF1">
        <property type="entry name" value="APOPTOSIS FACILITATOR BCL-2-LIKE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14965">
        <property type="entry name" value="SI:CH73-248E21.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035304373.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37937" checksum="90F47CE80A1E9895" modified="2023-06-28" version="1">MCSTSMHDLEDIPLEDDDSNSLEFKILTFYARHHVFKNPPAVFSPKLSRTRSLSQKALGTWSTDSWTQVSLPCKSSLSSEKHISLSKKKSSWRTFFRATEEESPPSSPKEIQAQGIQGPFAVERQCLKLQGGFHNQHWARSLSSVEQRLQCEAVDPKVASIANRVAEIVYSWPPAEDSHIQGSSFKLKESAPERLYLHFQGPQPVSCDSKKADGEDQVISRIVELLKYSGDHLGREMKKDKALMSSFQDGLSYSAFKTIADLFLRDIDTRGESEIRAHGFKAALAIDAIAKLTAIDNHPMNRMLGFGTKYLKEYFSPWVQQNGGWEKILGISHEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4H8</accession>
    <name>A0A9J7K4H8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formin-like protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC107977343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035295306.1">
        <property type="nucleotide sequence ID" value="XM_035439415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K4H8"/>
    <dbReference type="GeneID" id="107977343"/>
    <dbReference type="KEGG" id="cge:107977343"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035295306.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19290" checksum="D1D88DF27E29CC9C" modified="2023-06-28" version="1">MTLRLPPPPPPPPHRAGISVVRRQALDSNPGPCACVPSEHSANYAQLLLPSAPTAQPQPGDSGDSGEAGGGLGVRRAPPRPFPLPGTRRPAPARTPFTSYLPVREPLLLLSLRLLHHRGAPRQASPPASQIFPLYVRDGLRRGSKREAPPPRSARAPWRQLAEGPCWREGYPSTPRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K4N6</accession>
    <name>A0A9J7K4N6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein kinase SIK3</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Salt-inducible kinase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Serine/threonine-protein kinase QSK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">Sik3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Binds to and is activated by YWHAZ when phosphorylated on Thr-221. Interacts with 14-3-3 proteins. Interacts with HDAC4; this interaction leads to HDAC4 retention in the cytoplasm. Interacts with DEPTOR, MLST8/GbetaL, RICTOR and RPTOR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_035299542.1">
        <property type="nucleotide sequence ID" value="XM_035443651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774415"/>
    <dbReference type="CTD" id="23387"/>
    <dbReference type="OrthoDB" id="10045473at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14410">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="8"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="22">
        <location>
            <begin position="286"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="716"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="883"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1249"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="885"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="991"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1264"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035299542.1"/>
        </source>
    </evidence>
    <sequence length="1336" mass="148461" checksum="3F246413A7CC8C18" modified="2023-06-28" version="1">MPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKSQLDDENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGDADPNFDRLIAECQQLKEERETDPLNDDVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPGMPRAMTFQAPVNIQTEQTGTAMNISVPQVQLINPENQIIEPDGTVNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMDDLQKLLPGFPGVNPQAPFLQVTPNMNFMHNLLPMQSLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTSPTAEIPPDLQRQLGQQSFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGTNSSIKQLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPVSSAMIPSHGATSSSQFQGLPSHGAIFQQQPENCSPPPSVALTCLGIQQPSQSQPVTIQLQEPVDMLSNIAGTTAGSAGRGITINPSANQIQMQHRNNLMATFSYGHRPLSKQLSADSAEAHSLNMNRFSTANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFPPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPAEFAQLIKRQQQHRQQQQQQQQQQQEYHELFRHMNQGDAGSLAPSIGGQSMTEHQVLSYQTADSYHHHHHASPQHLLQIRVQEGISQGPSATPTHGYAHQPPLMHSESMEEDCLCEGAKAGFADKSPSTLTKGCHDSPLLLSTGGPGDPESLLGTVSQARELGIHPYGHQPAATFSRNKVPSRESIIGNCMDRSSPGQAMELPDHNGLVYPTRPSVNEPLRSRTLQRHHTIQNSDDAYVQLDTLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGEDEDCGTSCSATSTPRSPSAWSRPACRRIWRVCVQLEEEEADPKPTVSSNGAPLCHLCLHQNSAAPFPTLGTSRPPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KAJ3</accession>
    <name>A0A9J7KAJ3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LOW QUALITY PROTEIN: formin-like protein 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Fmnl1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304236.1">
        <property type="nucleotide sequence ID" value="XM_035448345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KAJ3"/>
    <dbReference type="GeneID" id="100765726"/>
    <dbReference type="KEGG" id="cge:100765726"/>
    <dbReference type="CTD" id="752"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000001">
        <property type="entry name" value="Formin-like 1, isoform CRA_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000036">
        <property type="entry name" value="Formin-like protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF2">
        <property type="entry name" value="FORMIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="582"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="958"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035304236.1"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117599" checksum="F514F8F27198DF86" modified="2023-06-28" version="1">MNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKVAADWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTDNVAASAEKSKPLEQSVEDLTKAPPSSVPKSRLTIKLTPAHSRKTLRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNVFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAENDSMAKIAELEKQLSQARKELETLRERFSESTPMGTARRIPEPEKVPAPTMVRPSALELKVEELEEKGLIRILRGPGDVVSIEILPGAVATPSGDNAATPGVPTDSPSPAESVPGAASPPPPPPPPPPPPLPNLQSQQEALSSAPPLAPPLPGCTEPPPAPPLPGDLPPHPHHPLGTDGPVPPPPPPPPGGPPDIPGEQGPEIGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMNDFEEQFKTKSQGPSLDLSTLKGKAAHKAPTKATLIEANRAKNLAITLRKGNLGADRICQAIETYDLQTLSLDFLELLTRFQPTEYERSLIARFEKERRPMEELSEEDRFMLRLSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLMGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGLELTQREFVRQDDCVVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSVFFPLFSRFTKAYKKAEQEVEQWKKEAAVDTSGREEPPAPKSPPKARRQQMDLISELKRKQQKEPLIYESDRDGAIEDIITDLRNQPYIRTDTGRRSARRRLPGPPLQVTTDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KB19</accession>
    <name>A0A9J7KB19_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lymphocyte antigen 6 complex locus protein G6f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100771134</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035307324.1">
        <property type="nucleotide sequence ID" value="XM_035451433.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315766.1">
        <property type="nucleotide sequence ID" value="XM_035459875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KB19"/>
    <dbReference type="GeneID" id="100771134"/>
    <dbReference type="KEGG" id="cge:100771134"/>
    <dbReference type="OrthoDB" id="9937043at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026524">
        <property type="entry name" value="LY6G6d/LY6G6f"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32286">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32286:SF10">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039909094" evidence="8">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035307324.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32492" checksum="9C9C71F529E6EF7C" modified="2023-06-28" version="1">MAVIVALHLLLFWCGCPRAAADSIQIIYAISGESAELPCPSPPSLLGGQLLSWFRSPAGGSSTILVAQIQVDRPVSDLGKPENDSRFKVLGNYSLLLEGPRDEDAGRYWCTVMDQNRKYQNWRVYDVSVLKGSQFSVKSPDGPSCSALLCSVVPARRLDSVTWLEGRNPVRGHAQYFWGEGAALLLVCPAEGLPETRGRRPRNIRCLMPQNKRFSFSLAAAPTEPSPTTCAPVQSWDVPRVLILLFTAGQGVTIIVLSIVLCRRRAQASRDREPSIPHFKPEVQVYENIHLARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KC41</accession>
    <name>A0A9J7KC41_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC107979351 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC107979351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035304358.1">
        <property type="nucleotide sequence ID" value="XM_035448467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KC41"/>
    <dbReference type="GeneID" id="107979351"/>
    <dbReference type="KEGG" id="cge:107979351"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.310.10">
        <property type="entry name" value="ENV polyprotein, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008981">
        <property type="entry name" value="FMuLV_rcpt-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49830">
        <property type="entry name" value="ENV polyprotein, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_035304358.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24176" checksum="3C6DB22A23402741" modified="2023-06-28" version="1">MMGDTSGSGEACFRGDDLLRRTGDCSVVLVYEMQLSQQLDLFPECRVTLLLFKELFLALPPACSSLRCRNSVHFFNSPPFQLWISGTHSSACSLQSGPGKQSRQEWLRGRQWRIRLYREGGDPGLLMTIKLKIEVSEYPRLKQQLRRDRFPVTRIRKHLRCTPLRREAPAEPTGLPYSPHTMALLKPPSALLHSPGTFLSSAAEPFAQHTGNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KCV5</accession>
    <name>A0A9J7KCV5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribitol-5-phosphate transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC113837384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6 7 8">17A/GY</strain>
            <tissue evidence="6 7 8">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LicD transferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305101.1">
        <property type="nucleotide sequence ID" value="XM_035449210.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305102.1">
        <property type="nucleotide sequence ID" value="XM_035449211.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305103.1">
        <property type="nucleotide sequence ID" value="XM_035449212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KCV5"/>
    <dbReference type="GeneID" id="113837384"/>
    <dbReference type="KEGG" id="cge:113837384"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055105">
        <property type="entry name" value="FKRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF31">
        <property type="entry name" value="RIBITOL 5-PHOSPHATE TRANSFERASE FKRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22921">
        <property type="entry name" value="FKRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035305101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035305102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_035305103.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="54699" checksum="709BD1C00C75FF33" modified="2023-06-28" version="1">MRLTRCWAALAAAIILNLLVFFYVSWLQHQPRNSRARGPRRTPATGPRVTVLIREFEAFDNAVPELVDSFLQQDPAQPVVVAADTLPYPPLALPRIPNVRLALLQPALDRSAAASRPETYVATEFVALVPDGTRAESPGHLERMVEALRGSSARLVAAPVATANPARCLALNISLREWTAHYGPAPGAPRCDALDGDAVVLLRSRDLFNLSAPLARPLATSLFLQTALRGWTVQLLGLTFAAARQPPLATAHARWKADREGRSRRAALLRALGIRLVSWGEGGRLEWFGCHKESARCFGTVAGDTPSYLYEGRWTPPCCLRALRETARYVVGVLEAAGVRYWLEGGSLLGAARHGDIIPWDYDVDLGIYLEDVGNCEQLRGAEAGSVVDERGFVWEKAVEGDFFRVQYSESNHLHVDLWPFYPRNGVMTKDTWLDHRQDVEFPEHFLQPLVPLAFAGFMAQAPNNYRRFLELKFGPGVIENPEYPNPALLSLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3GTT2</accession>
    <name>G3GTT2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">LOC100763833</name>
        <name evidence="10" type="ORF">I79_001071</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the intercrine beta (chemokine CC) family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000022">
        <property type="protein sequence ID" value="EGV94377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003495840.1">
        <property type="nucleotide sequence ID" value="XM_003495792.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282301.1">
        <property type="nucleotide sequence ID" value="XM_027426500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GTT2"/>
    <dbReference type="SMR" id="G3GTT2"/>
    <dbReference type="STRING" id="10029.G3GTT2"/>
    <dbReference type="PaxDb" id="10029-XP_007609471.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012426.1">
        <property type="protein sequence ID" value="ENSCGRP00001008306.1"/>
        <property type="gene ID" value="ENSCGRG00001010610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763833"/>
    <dbReference type="KEGG" id="cge:100763833"/>
    <dbReference type="eggNOG" id="ENOG502S6ZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278316"/>
    <dbReference type="OMA" id="PLTCCYS"/>
    <dbReference type="OrthoDB" id="8900217at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031727">
        <property type="term" value="F:CCR2 chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038148">
        <property type="term" value="P:chemokine (C-C motif) ligand 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048245">
        <property type="term" value="P:eosinophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035684">
        <property type="term" value="P:helper T cell extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000427">
        <property type="term" value="P:positive regulation of apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090265">
        <property type="term" value="P:positive regulation of immune complex clearance by monocytes and macrophages"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010759">
        <property type="term" value="P:positive regulation of macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050870">
        <property type="term" value="P:positive regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010574">
        <property type="term" value="P:regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00272">
        <property type="entry name" value="Chemokine_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000002">
        <property type="entry name" value="C-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000827">
        <property type="entry name" value="Chemokine_CC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF117">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00472">
        <property type="entry name" value="SMALL_CYTOKINES_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4 8" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044524208" description="C-C motif chemokine" evidence="8">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="9">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV94377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027282301.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15858" checksum="2F0236D229AC0A90" modified="2011-11-16" version="1">MQFSARTLLCLLLTVAACSIYVLAQPDAVNSPLTCCYSFTAKRIPEKRLESYKRITSSKCPKEAVIFITKLKREICADPKQDWVQTYTKKLDQSQAKSEAATVYKTAPLNANLTHESAVNASTTAFPTTDLRTSVRVTSMTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3GU60</accession>
    <name>G3GU60_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylethanolamine-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">HCNPpp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Pebp1</name>
        <name evidence="16" type="ORF">I79_001211</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000026">
        <property type="protein sequence ID" value="EGV93141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643310.1">
        <property type="nucleotide sequence ID" value="XM_007645120.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269989.1">
        <property type="nucleotide sequence ID" value="XM_027414188.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GU60"/>
    <dbReference type="SMR" id="G3GU60"/>
    <dbReference type="STRING" id="10029.G3GU60"/>
    <dbReference type="PaxDb" id="10029-XP_007628615.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024550.1">
        <property type="protein sequence ID" value="ENSCGRP00001020306.1"/>
        <property type="gene ID" value="ENSCGRG00001019504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753772"/>
    <dbReference type="KEGG" id="cge:100753772"/>
    <dbReference type="CTD" id="5037"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QEVICYE"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000003">
        <property type="entry name" value="phosphatidylethanolamine-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF151">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0722">Serine protease inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV93141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027269989.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20923" checksum="DB9117DF876C60C6" modified="2011-11-16" version="1">MPADISQWSGPLSLQEVDERPQHALRVAYAGVEVDELGKVLTPTQVKNRPSSISWDGLDPGKLYTLVLTDPDAPSRKDPKFREWHHFLVVNMKGNDISSGKVLSDYVGSGPPSGTGLHRYVWLVYEQDKPLNCDEPILSNRSGDHRGKFKVAAFRKKYHLGAPVAGTCYQAEWDDYVPKLYEQLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3GU92</accession>
    <name>G3GU92_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lupus La protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">La autoantigen homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">La ribonucleoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Ssb</name>
        <name evidence="16" type="ORF">I79_001246</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with DDX15. May interact with RUFY1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000027">
        <property type="protein sequence ID" value="EGV95649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643614.1">
        <property type="nucleotide sequence ID" value="XM_007645424.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276023.1">
        <property type="nucleotide sequence ID" value="XM_027420222.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GU92"/>
    <dbReference type="SMR" id="G3GU92"/>
    <dbReference type="STRING" id="10029.G3GU92"/>
    <dbReference type="PaxDb" id="10029-XP_007628699.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032225.1">
        <property type="protein sequence ID" value="ENSCGRP00001027977.1"/>
        <property type="gene ID" value="ENSCGRG00001024831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100689103"/>
    <dbReference type="KEGG" id="cge:100689103"/>
    <dbReference type="CTD" id="6741"/>
    <dbReference type="eggNOG" id="KOG4213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00830000128380"/>
    <dbReference type="OMA" id="QFERSIY"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075522">
        <property type="term" value="P:IRES-dependent viral translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071045">
        <property type="term" value="P:nuclear histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903608">
        <property type="term" value="P:protein localization to cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042780">
        <property type="term" value="P:tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08028">
        <property type="entry name" value="LARP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12541">
        <property type="entry name" value="RRM2_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000336">
        <property type="entry name" value="lupus La protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000366">
        <property type="entry name" value="Lupus La protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000402">
        <property type="entry name" value="Lupus La protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF166">
        <property type="entry name" value="LUPUS LA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="14">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="111"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="15">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="325"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV95649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027276023.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46867" checksum="B09BC76338655F51" modified="2011-11-16" version="1">MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLDIMIKFNRLNRLTTDFNVIVQALSKSKAKLMEVSADKTKIRRSPSRPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLDDKGQILNIQMRRTLHKTFKGSIFAVFDSIQSAKKFVDTPGQKYKDTSLLILFKEDYFAKKNEERKQSKVEAKLKAKQEHEGRHKSGSTETRPLEGKMGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALEKARSAHNGNLQLRNKKVTWKVLEGHAEKDAMKKIMEDQQESLNKWKSKGGGGGGRRFKGKGKGNRPPYGGAPKGRGQFQGRRTRFDDDDHHHHRRGPMKRGRDGRDREEPASKHKKRENGARDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3GU94</accession>
    <name>G3GU94_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">Mettl5</name>
        <name evidence="4" type="ORF">I79_001249</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000027">
        <property type="protein sequence ID" value="EGV95652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003495992.1">
        <property type="nucleotide sequence ID" value="XM_003495944.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027276024.1">
        <property type="nucleotide sequence ID" value="XM_027420223.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GU94"/>
    <dbReference type="SMR" id="G3GU94"/>
    <dbReference type="STRING" id="10029.G3GU94"/>
    <dbReference type="PaxDb" id="10029-XP_007628698.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031813.1">
        <property type="protein sequence ID" value="ENSCGRP00001027566.1"/>
        <property type="gene ID" value="ENSCGRG00001024537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765596"/>
    <dbReference type="KEGG" id="cge:100765596"/>
    <dbReference type="CTD" id="29081"/>
    <dbReference type="eggNOG" id="KOG3420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000227"/>
    <dbReference type="OMA" id="DVVYSIH"/>
    <dbReference type="OrthoDB" id="419617at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="3">
        <location>
            <begin position="51"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV95652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027276024.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23749" checksum="E40ADAF1D6ABFC5B" modified="2011-11-16" version="1">MKKLRLKELESRLQEVDGFETPKLLLEQYPTRPHIAACMLYTIHNTYDDIKNKVVADLGCGCGVLSIGASMLGAGLCVGFDIDEDALEIFNRNVEEFELTNVDMIQCDVYTLSNRMSKLFDTVIMNPPFGTKNNKGTDMAFLKTALGMARTAVYSLHKSSTREHIQKKAAEWKVKIEIIAELRYDLPALYNFHKKKSVDIEVDLIRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYQ1</accession>
    <name>G3GYQ1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyanocobalamin reductase / alkylcobalamin dealkylase</fullName>
            <ecNumber evidence="6">1.16.1.6</ecNumber>
            <ecNumber evidence="5">2.5.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Alkylcobalamin:glutathione S-alkyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">CblC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cyanocobalamin reductase (cyanide-eliminating)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Methylmalonic aciduria and homocystinuria type C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 29" type="primary">Mmachc</name>
        <name evidence="25" type="ORF">I79_002956</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="26" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 cyanocob(III)alamin + 2 apo-[cyanocobalamin reductase] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16113"/>
            <dbReference type="Rhea" id="RHEA-COMP:14717"/>
            <dbReference type="Rhea" id="RHEA-COMP:14718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
            <dbReference type="EC" id="1.16.1.6"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:16115"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63136"/>
            <dbReference type="Rhea" id="RHEA-COMP:14730"/>
            <dbReference type="Rhea" id="RHEA-COMP:14731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:60488"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
            <dbReference type="ChEBI" id="CHEBI:146184"/>
            <dbReference type="EC" id="2.5.1.151"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:63137"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>apo-[alkylcobalamin reductase] + an R-cob(III)alamin + glutathione = cob(I)alamin-[alkylcobalamin reductase] + an S-substituted glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40719"/>
            <dbReference type="Rhea" id="RHEA-COMP:14730"/>
            <dbReference type="Rhea" id="RHEA-COMP:14731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:60488"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:140785"/>
            <dbReference type="EC" id="2.5.1.151"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:40720"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63132"/>
            <dbReference type="Rhea" id="RHEA-COMP:14730"/>
            <dbReference type="Rhea" id="RHEA-COMP:14731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:60488"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
            <dbReference type="ChEBI" id="CHEBI:141467"/>
            <dbReference type="EC" id="2.5.1.151"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:63133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MMACHC family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.6" evidence="6"/>
    <dbReference type="EC" id="2.5.1.151" evidence="5"/>
    <dbReference type="EMBL" id="JH000068">
        <property type="protein sequence ID" value="EGV94594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497421.1">
        <property type="nucleotide sequence ID" value="XM_003497373.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027258374.1">
        <property type="nucleotide sequence ID" value="XM_027402573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GYQ1"/>
    <dbReference type="STRING" id="10029.G3GYQ1"/>
    <dbReference type="PaxDb" id="10029-XP_007620231.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023934.1">
        <property type="protein sequence ID" value="ENSCGRP00001019690.1"/>
        <property type="gene ID" value="ENSCGRG00001019062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751045"/>
    <dbReference type="KEGG" id="cge:100751045"/>
    <dbReference type="CTD" id="25974"/>
    <dbReference type="eggNOG" id="KOG4552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FQVGWYN"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033787">
        <property type="term" value="F:cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12959">
        <property type="entry name" value="MMACHC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032037">
        <property type="entry name" value="MMACHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457:SF2">
        <property type="entry name" value="CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457">
        <property type="entry name" value="METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16690">
        <property type="entry name" value="MMACHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGV94594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027258374.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31705" checksum="928D81CB19CEDADE" modified="2011-11-16" version="1">MERHVAELKLKIEDSLCPFGFEVYPFQVAWYNELLPPAFHLPFPGPTLAFLVLSTPAMFDKALKPFLKSYHLQPLRDPVDQCVSYHLRSVVEKFPELRMEVIADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVYADPWGTQHIAGVCIHPRFGGWFAIRGVMLLPGTEVPDLPLRKPPDCVPTRAGRIALLEGFNFHWRDWTYRDAVTPEERYSEEQKMYFSTPPAQRLALLGLSQPSEHLSTTSEHPSSMLTKPQDSSRARSWLSPSVSPPVSPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3H1Y8</accession>
    <name>G3H1Y8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Regulator of chromosome condensation</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chromosome condensation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Rcc1</name>
        <name evidence="22" type="ORF">I79_004185</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with RAN. Interacts with KPNA3. Interacts (via N-terminus and RCC1 repeats) with KPNA4. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000110">
        <property type="protein sequence ID" value="EGW01158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016825995.1">
        <property type="nucleotide sequence ID" value="XM_016970506.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295447.1">
        <property type="nucleotide sequence ID" value="XM_035439556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H1Y8"/>
    <dbReference type="STRING" id="10029.G3H1Y8"/>
    <dbReference type="PaxDb" id="10029-XP_007634557.1"/>
    <dbReference type="GeneID" id="100769945"/>
    <dbReference type="CTD" id="1104"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H1Y8"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000008">
        <property type="entry name" value="regulator of chromosome condensation isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF9">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="21">
        <location>
            <begin position="70"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="224"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="346"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="19">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGW01158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035295447.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="48887" checksum="A224D120B9693F14" modified="2011-11-16" version="1">MQFGKVVCIRSSTQNFVKLGKHLFIAVLSLERKMPPKRIAKRRSPPEDAIPKSKKVKVSHRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVTVLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSAEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDMPVVKVASGNDHLVMLTTEGDLYTLGCGDQGQLGRVPELFANRGGRQGLERLLVPRCVLLKARGCRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPIVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQEEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3H4R1</accession>
    <name>G3H4R1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THAP domain containing, apoptosis associated protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 11">THAP domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">LOC100760567</name>
        <name evidence="7" type="ORF">I79_005268</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH000145">
        <property type="protein sequence ID" value="EGV93248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248192.1">
        <property type="nucleotide sequence ID" value="XM_027392391.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H4R1"/>
    <dbReference type="STRING" id="10029.G3H4R1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013752.1">
        <property type="protein sequence ID" value="ENSCGRP00001009535.1"/>
        <property type="gene ID" value="ENSCGRG00001011633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760567"/>
    <dbReference type="GeneTree" id="ENSGT00940000161088"/>
    <dbReference type="OMA" id="RGTSEHI"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026521">
        <property type="entry name" value="THAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV93248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027248192.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24924" checksum="463A2B4014646FA9" modified="2011-11-16" version="1">MPTNCAAAGCAATYNKHINVSFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNDSFTPSGPCTLKPNSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKMCLQRERRATRRWVKATCFVKNLEASNMLPKGIAEHILPTALSSLPLEDCKLLEQDQQGKTLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G3HBU1</accession>
    <name>G3HBU1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="22">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27 30" type="primary">Rhot2</name>
        <name evidence="26" type="ORF">I79_007891</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="27" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20 22">Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Can hydrolyze GTP, ATP and UTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>UTP + H2O = UDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:64901"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer. Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules. Interacts with ARMCX3. Found in a complex with KIF5B, OGT, RHOT1 and TRAK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Mitochondrion outer membrane</location>
            <topology evidence="1 22">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="22"/>
    <dbReference type="EMBL" id="JH000273">
        <property type="protein sequence ID" value="EGW04378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640327.1">
        <property type="nucleotide sequence ID" value="XM_007642137.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280901.1">
        <property type="nucleotide sequence ID" value="XM_027425100.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HBU1"/>
    <dbReference type="STRING" id="10029.G3HBU1"/>
    <dbReference type="PaxDb" id="10029-XP_007606710.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007789.1">
        <property type="protein sequence ID" value="ENSCGRP00001005102.1"/>
        <property type="gene ID" value="ENSCGRG00001006615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760480"/>
    <dbReference type="CTD" id="89941"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158109"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019725">
        <property type="term" value="P:cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097345">
        <property type="term" value="P:mitochondrial outer membrane permeabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047497">
        <property type="term" value="P:mitochondrion transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000021">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001117">
        <property type="entry name" value="Mitochondrial Rho GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 22" id="KW-0106">Calcium</keyword>
    <keyword evidence="15 22" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 22" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="25">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="25">
        <location>
            <begin position="415"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00093331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00093530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGW04378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027280901.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="69034" checksum="AC157682E6478E59" modified="2011-11-16" version="1">MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSEAEQTEEELQEEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGRTAAGPRLPIILVGNKSDLRPGSTMEAVLPIMSQFPEIETCVECSAKHLRNISEMFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQALDDVKRVVCKNVAGGVQDNQLTLEGFLFLNTLFIQRGRHETTWTILRRFGYSDSLELTPDYLCPPLHVPPGCSTELNHRGYQFVQRVFEKHDQDHDGALSSTELQNLFSVFSVAPWGPELPYTVPTQAGRLTLHGYLCQWTLVTYLDVQQCLAHLGYLGYPTLCEQDSQAQAITVTREKRIDQEKGQTQRNVLMCKVLGARGVGKSAFLQAFLGHSLKEARELPEEHPMHTINTVRVSGQEKYLILCEVSADSLLDASLDPTCDVACLMFDSSDPKTFVHCATIYKHHYMDGQTPCLFISSKADLPEGVAEPGLSPADFCRRHRLPAPTSFSCLGPAQPSPAVFTQLATMATFPHLMHTELHPPSFWLRGMLVAVGTAVAAVLSFSLYRVLVKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3HLA5</accession>
    <name>G3HLA5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Epithelial membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Emp1</name>
        <name evidence="9" type="ORF">I79_011491</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PMP-22/EMP/MP20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="JH000483">
        <property type="protein sequence ID" value="EGW05686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504468.1">
        <property type="nucleotide sequence ID" value="XM_003504420.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285700.1">
        <property type="nucleotide sequence ID" value="XM_027429899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HLA5"/>
    <dbReference type="STRING" id="10029.G3HLA5"/>
    <dbReference type="PaxDb" id="10029-XP_007625022.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009467.1">
        <property type="protein sequence ID" value="ENSCGRP00001006072.1"/>
        <property type="gene ID" value="ENSCGRG00001008122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753041"/>
    <dbReference type="KEGG" id="cge:100753041"/>
    <dbReference type="CTD" id="2012"/>
    <dbReference type="eggNOG" id="ENOG502S028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182696"/>
    <dbReference type="OMA" id="CWMCILI"/>
    <dbReference type="OrthoDB" id="8678517at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000026">
        <property type="entry name" value="Epithelial membrane protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003932">
        <property type="entry name" value="EMP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004032">
        <property type="entry name" value="PMP22_EMP_MP20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF6">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01453">
        <property type="entry name" value="EPMEMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01454">
        <property type="entry name" value="EPMEMPROT1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01221">
        <property type="entry name" value="PMP22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01222">
        <property type="entry name" value="PMP22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW05686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027285700.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17947" checksum="EFBE8C04F532DD2B" modified="2011-11-16" version="1">MLVLLAGIFVVHIATAIMLFVSTISNVWMVSSDVKSSVGLWKNCTNGNCGGSLVYGNEDALKAVQAFMILSIIFSVISLVVFVFQLFTMEKGNRFFLSGSTMLVCWFCILVGVSIYTHHYAHRDVNITANDHQGYCFILTWICFCFSFIIGILYMVLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3HVZ6</accession>
    <name>G3HVZ6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC107978682</name>
        <name evidence="11" type="ORF">I79_015143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000810">
        <property type="protein sequence ID" value="EGW02859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296663.1">
        <property type="nucleotide sequence ID" value="XM_035440772.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315072.1">
        <property type="nucleotide sequence ID" value="XM_035459181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HVZ6"/>
    <dbReference type="STRING" id="10029.G3HVZ6"/>
    <dbReference type="PaxDb" id="10029-XP_007607481.1"/>
    <dbReference type="GeneID" id="107978682"/>
    <dbReference type="KEGG" id="cge:107978682"/>
    <dbReference type="eggNOG" id="KOG1780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HVZ6"/>
    <dbReference type="OrthoDB" id="9557128at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000017">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF26">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW02859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035296663.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8526" checksum="623302BF6FF309BF" modified="2011-11-16" version="1">MSKAHPPELKKFMDKKLSLKLNGGRHVQGILWGFDPFMNLVIDECVEMATSGQQNNIGMVVIRGNSIIMLEALERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3HZ43</accession>
    <name>G3HZ43_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bestrophin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Best3</name>
        <name evidence="11" type="ORF">I79_016338</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Forms calcium-sensitive chloride channels. Permeable to bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000957">
        <property type="protein sequence ID" value="EGW08008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003508450.1">
        <property type="nucleotide sequence ID" value="XM_003508402.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248160.1">
        <property type="nucleotide sequence ID" value="XM_027392359.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HZ43"/>
    <dbReference type="STRING" id="10029.G3HZ43"/>
    <dbReference type="PaxDb" id="10029-XP_007636990.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014610.1">
        <property type="protein sequence ID" value="ENSCGRP00001010389.1"/>
        <property type="gene ID" value="ENSCGRG00001012290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759541"/>
    <dbReference type="KEGG" id="cge:100759541"/>
    <dbReference type="CTD" id="144453"/>
    <dbReference type="eggNOG" id="KOG3547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157777"/>
    <dbReference type="OMA" id="DWLWNYE"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043271">
        <property type="term" value="P:negative regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF2">
        <property type="entry name" value="BESTROPHIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW08008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027248160.1"/>
        </source>
    </evidence>
    <sequence length="668" mass="76432" checksum="F0C2E28E1ABDD9A1" modified="2011-11-16" version="1">MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLVLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFDHLKSPHLKYWVPFVWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTIQMGLGSEFPAEDWLWNYEKQGHRHSMIRRVKRFLSTHEHPGSPRRRTFGRQASDSSMFFPPSPSRDLLDVPSRNPHRASPTRKQSQSLEGSPKLHSSMGELSTIRETSRTSTLQSLTPQSSMRASPTKMPQVPEVLITAAEAPASSSDSHPHDSATSTLSLEFTGVQPSRIEQQIDPSGKTPLGDPNPQIVSTSPERDLFKFDEDLADDRFPQRWSLPELRESRHTSLGNLAPDPMSPGAALLLGTETSSETSVIHPRAGSGIPPDILYLMESLDAKETDILEFNNEHPEESPKGTPQRPRTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3HZT8</accession>
    <name>G3HZT8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19 22 23 24">Bromodomain and PHD finger-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22 23 24" type="primary">Brpf3</name>
        <name evidence="19" type="ORF">I79_016602</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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            <strain evidence="21">17A/GY</strain>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="21">17A/GY</strain>
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    <reference evidence="22 23 24" key="5">
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="22 23 24">17A/GY</strain>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Histone_Mod_Regulator"/>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR13793:SF19">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="9 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
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            <begin position="605"/>
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        <source>
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    <evidence type="ECO:0000313" key="24">
        <source>
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    <sequence length="1204" mass="134772" checksum="FF8AA2FADCC7C793" modified="2011-11-16" version="1">MRKPRRKSRQSAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPAKSKKSSSKGKKKESCSKHASGTSSHLPQPSFRVVDTGSQPEAPPLPAAYYRYIEKPPEDQDAEVEYDMDEEDLAWLDMVNEKRRADGHSSVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPSVAPARRKGDSPRSLIEAGDEDGLKEDGREEEEEEAEEEDQEGQGGVGSPHKGVSKKSKMSLKQKIKKEPEEAGRETPSTTAPMVTVPQIPSYRLNKICSGLSFQKKTQFMQRLHNYWLLKRQARNGAPLIRRLHSHSQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVRVQQAAMELELMPFTVLLRTTLDLLQEKDPAHIFAEPVSLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVANCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRMLRREINALRQKLAQPAPPQLLSLNKTVSNGELAAGPRGDTAVLEQALQEEPEDDGDRDDSKLPAPPTLEPTGPAPSLSEQESPSDPPTLKPISDSKPSSRSLKSRKVEEEELLEKPALQLGSEPLQCLLSDNGVDRLSLINPDSPPGTPLGGVGRRTSVLFKKARNGVKLPRSPDGTLEDGEDSGTVGSPASPASTEDEHCSRKRPRSGSCSDSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLSGGLAFEAGSGLTPPKRSRGKPALSRVPFLEGVNGDSDHSGSGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVASTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G3I049</accession>
    <name>G3I049_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18 21 22">Zinc finger protein 213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">Znf213</name>
        <name evidence="18" type="ORF">I79_016718</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22">17A/GY</strain>
            <tissue evidence="21 22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000995">
        <property type="protein sequence ID" value="EGV93648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007647516.1">
        <property type="nucleotide sequence ID" value="XM_007649326.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016834323.1">
        <property type="nucleotide sequence ID" value="XM_016978834.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280653.1">
        <property type="nucleotide sequence ID" value="XM_027424852.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280654.1">
        <property type="nucleotide sequence ID" value="XM_027424853.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I049"/>
    <dbReference type="STRING" id="10029.G3I049"/>
    <dbReference type="PaxDb" id="10029-XP_007619786.1"/>
    <dbReference type="GeneID" id="100773530"/>
    <dbReference type="KEGG" id="cge:100773530"/>
    <dbReference type="CTD" id="7760"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I049"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000869">
        <property type="entry name" value="Zinc finger protein 213"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000628">
        <property type="entry name" value="zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="16">
        <location>
            <begin position="46"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
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            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV93648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027280653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027280654.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="53285" checksum="2230B88DDD01B7C5" modified="2011-11-16" version="1">MASFPELQDHAPGEEDGLLIVKVEDCSWEQEPAQPVDSKDSEETCRQRFRQFCYRDVGGPHEAFSQLWELCCRWLRPELHSKEQILELLVLEQFLAVLPREIQAQVQRQHLGSGEEAVALVEDIQNQSLKAWPQDEPSEVEPKAAVQGLPATGPPQKARVQKQLPASQEQHHQAQLPVLKEGRTGEMMDVYFSSAVHLSGRPELGHISSVQKPVALGDIPFYFSREEWGSLDPAQRDLFWDIKRENSRNAALGLGSKSQSERAPPDEAMTALSGQTDCEVTVSWNPEEAETEVWESETPPRTALGALVVTRRGRPPTRRRQFRDLVTEKPHSCGQCGKRFRWGSDLARHQRTHTGEKPHKCPECDKSFRSSSDLVRHQGVHTGEKPFSCAECGKSFSRSAYLADHQRIHTGEKPFGCSDCGKSFSLRSYLLDHRRVHTGERPFGCGECDKSFKQRAHLIAHQSLHAKMAQPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3I189</accession>
    <name>G3I189_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="8">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Naa11</name>
        <name evidence="17" type="ORF">I79_017139</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="8"/>
    <dbReference type="EMBL" id="JH001055">
        <property type="protein sequence ID" value="EGW10743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003509102.1">
        <property type="nucleotide sequence ID" value="XM_003509054.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243409.1">
        <property type="nucleotide sequence ID" value="XM_027387608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I189"/>
    <dbReference type="SMR" id="G3I189"/>
    <dbReference type="STRING" id="10029.G3I189"/>
    <dbReference type="PaxDb" id="10029-XP_007606539.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001729.1">
        <property type="protein sequence ID" value="ENSCGRP00001001562.1"/>
        <property type="gene ID" value="ENSCGRG00001001343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770650"/>
    <dbReference type="KEGG" id="cge:100770650"/>
    <dbReference type="CTD" id="84779"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164242"/>
    <dbReference type="OMA" id="TISHRWR"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000014">
        <property type="entry name" value="N-alpha-acetyltransferase 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW10743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027243409.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24344" checksum="FF89E089B686B42A" modified="2011-11-16" version="1">MNIRNARPDDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDEDGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFSAKYVSLHVRKSNRAALHLYSNTLNFQVSEVEPKYYADGEDAYAMKRDLSQMADELRRQLVLKKGKYVVLGSSENQEVQDSTLPGAEEACQLESPAGDSTDDQGSSEDLDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>G3I2I1</accession>
    <name>G3I2I1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 19">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 26" type="primary">Mcm4</name>
        <name evidence="22" type="ORF">I79_017612</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Interacts with MCMBP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="JH001134">
        <property type="protein sequence ID" value="EGW06572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003509503.1">
        <property type="nucleotide sequence ID" value="XM_003509455.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269236.1">
        <property type="nucleotide sequence ID" value="XM_027413435.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I2I1"/>
    <dbReference type="SMR" id="G3I2I1"/>
    <dbReference type="STRING" id="10029.G3I2I1"/>
    <dbReference type="GlyGen" id="G3I2I1">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007638104.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024701.1">
        <property type="protein sequence ID" value="ENSCGRP00001020457.1"/>
        <property type="gene ID" value="ENSCGRG00001019609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770466"/>
    <dbReference type="KEGG" id="cge:100770466"/>
    <dbReference type="CTD" id="4173"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="21">
        <location>
            <begin position="457"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGW06572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027269236.1"/>
        </source>
    </evidence>
    <sequence length="862" mass="96543" checksum="31BCE6608156D185" modified="2011-11-16" version="1">MSSPASTPSRRSSRRGRATPTQTLRSEESRSSPSRRRRGEDSSTGELQPMPTSPGVDLQSPAAQNALFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSARKGLQVDLQSDGTAAEDIAASEQSLGQKLVIWGTDVNVATCKENFQRFLQCFTDPLAKEEENVGIDITQPLYMQRLGEINITGEPFLNVNCEHIKAFGKNLYKQLISYPQEVIPTFDMAVNEIFFERYPDSILEHQIQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPCTCAHCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVVLFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSENRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEEEFLDMAVLKDYIAYAHSTITPRLSEEASQALIEAYVNMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRFSDKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKLILSKGKTPALKYQQLFEDIRGQSDTAITKDMFEEALRALADDDFLTVTGKTVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3I8E9</accession>
    <name>G3I8E9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Keratin-associated protein 16-1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Putative keratin-associated protein 10-like ENSP00000375147-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC100761497</name>
        <name evidence="6" type="ORF">I79_019813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with hair keratins.</text>
    </comment>
    <dbReference type="EMBL" id="JH001501">
        <property type="protein sequence ID" value="EGW11442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007650046.1">
        <property type="nucleotide sequence ID" value="XM_007651856.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283520.1">
        <property type="nucleotide sequence ID" value="XM_027427719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I8E9"/>
    <dbReference type="GlyGen" id="G3I8E9">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007631948.1"/>
    <dbReference type="GeneID" id="100761497"/>
    <dbReference type="KEGG" id="cge:100761497"/>
    <dbReference type="eggNOG" id="KOG4726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I8E9"/>
    <dbReference type="OMA" id="VICEPSC"/>
    <dbReference type="OrthoDB" id="9451506at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002494">
        <property type="entry name" value="KAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23262">
        <property type="entry name" value="KERATIN ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23262:SF55">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 16-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13885">
        <property type="entry name" value="Keratin_B2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0416">Keratin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGW11442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027283520.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="51001" checksum="7452DACE8FE1FFB6" modified="2011-11-16" version="1">MSGCCCSRKCPSLPAISLCSTEVSCGGPICLPSSCRSQTWQLVTCEDSCGSSGCGSQCCQPSGSLSSCCQPVCCEATICEPSCSVSSCAQPVCCTATVCEPSCSSGSCCQPVCCEATICEPSCSVSTCAQPVCCEATVCQPSCSVSSCQPVCCETTPCQPVLCLPASCQPVICEPSCCSAVCTVPASCQPMICEPVVCEPACCQPVCPTPSCCPSVCSAASSCQPVCCDSSPCEPPCSESTACQPATCMALVCEPVCLRPVCCVQSPCEPPCVSSSCQDSSCCVSSICQPVCPEPSPCLPSVCVPSPCQPSCYIVKRCRSVSCEPVSCPPTSCQPLCCRPGSSASAVCQPACPPRTFYIPSSCRQPCSPVSCRPICRPICSGPITLRQPYVTSITYRPACYRSCYSILRRPTCLASYSYRPVCSRQPCADSDNSKPECIKSTSSQPDCPDSTPCKTEVSDETPCQPSEIKPASPITREATAPQSAASKPTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3I9V5</accession>
    <name>G3I9V5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">Nfya</name>
        <name evidence="9" type="ORF">I79_020365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13 14">17A/GY</strain>
            <tissue evidence="12 13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001648">
        <property type="protein sequence ID" value="EGW00247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511806.1">
        <property type="nucleotide sequence ID" value="XM_003511758.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027239879.1">
        <property type="nucleotide sequence ID" value="XM_027384078.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250326.1">
        <property type="nucleotide sequence ID" value="XM_027394525.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250327.1">
        <property type="nucleotide sequence ID" value="XM_027394526.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027250328.1">
        <property type="nucleotide sequence ID" value="XM_027394527.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I9V5"/>
    <dbReference type="STRING" id="10029.G3I9V5"/>
    <dbReference type="GlyGen" id="G3I9V5">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007637958.1"/>
    <dbReference type="GeneID" id="100755500"/>
    <dbReference type="KEGG" id="cge:100755500"/>
    <dbReference type="CTD" id="4800"/>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3I9V5"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW00247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027250326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027250327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027250328.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="36859" checksum="80471C307769086C" modified="2011-11-16" version="1">MEQYTTNSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDGPHIQDPNQADEEAMTQIIRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3IA32</accession>
    <name>G3IA32_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">JAB1-containing signalosome subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Cops4</name>
        <name evidence="12" type="ORF">I79_020448</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. Interacts with TOR1A; the interaction is direct and associates TOR1A and SNAPIN with the CSN complex. Interacts with STON2; controls STON2 neddylation levels. Interacts with ERCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001667">
        <property type="protein sequence ID" value="EGV98918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511882.1">
        <property type="nucleotide sequence ID" value="XM_003511834.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243413.1">
        <property type="nucleotide sequence ID" value="XM_027387612.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IA32"/>
    <dbReference type="SMR" id="G3IA32"/>
    <dbReference type="STRING" id="10029.G3IA32"/>
    <dbReference type="PaxDb" id="10029-XP_007609646.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000251.1">
        <property type="protein sequence ID" value="ENSCGRP00001000227.1"/>
        <property type="gene ID" value="ENSCGRG00001000211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755032"/>
    <dbReference type="KEGG" id="cge:100755032"/>
    <dbReference type="CTD" id="51138"/>
    <dbReference type="eggNOG" id="KOG1497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153510"/>
    <dbReference type="OMA" id="KNIMHTV"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000130">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041406">
        <property type="entry name" value="CSN4_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18420">
        <property type="entry name" value="CSN4_RPN5_eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="11">
        <location>
            <begin position="197"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV98918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027243413.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46311" checksum="305AF13E2ECD58A2" modified="2011-11-16" version="1">MAAAVRQDLAQLMNLSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKVQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3IAR5</accession>
    <name>G3IAR5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Afadin- and alpha-actinin-binding protein isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Afadin-and alpha-actinin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">SSX family member 2 interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Ssx2ip</name>
        <name evidence="11" type="ORF">I79_020694</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001743">
        <property type="protein sequence ID" value="EGW03506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007650718.1">
        <property type="nucleotide sequence ID" value="XM_007652528.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251719.1">
        <property type="nucleotide sequence ID" value="XM_027395918.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IAR5"/>
    <dbReference type="STRING" id="10029.G3IAR5"/>
    <dbReference type="PaxDb" id="10029-XP_007630288.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024254.1">
        <property type="protein sequence ID" value="ENSCGRP00001020010.1"/>
        <property type="gene ID" value="ENSCGRG00001019268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759551"/>
    <dbReference type="KEGG" id="cge:100759551"/>
    <dbReference type="CTD" id="117178"/>
    <dbReference type="eggNOG" id="ENOG502QQJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QHCKEMI"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000145">
        <property type="term" value="P:regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF1">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW03506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027251719.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="71222" checksum="327E9AB87CBAB89C" modified="2011-11-16" version="1">MGDWMTVTDPSLCTESKNLHQYTSETKMSPSSLYSQQVLCSSIPLSKNVHSVFSAFCTEENIEQSISYLDQELTTFGFPSLYEESKSKETKRELNIVAVLNCMNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLKEQLETSRREMIGLQERDRQLQCKNRNLHQLLKNEKDEVQKLQNIIASRATQYNHDMKRKEREYNKLKERLHQLVMNKKDKKIAMDVLNYVGRADGKRGSWRTDKTEARNEDEMYKLLLNDYECRQKQILTENAELKKVLQQMKKEMISLLSPQKKKPRERAEDGTGTAVISDIEDDLGELSRESAWGLSCDTVREQLTNSIRRQWRILKSHVEKLDNQVSKVHSEGLNDEDVISRQDHEEETEKLELEIQQCKEMIRAQQQLLQQQLATTCDDDTTSLLRDCYLLEEKERLKEEWSLFKEQKKNFERERRSFTEAAIRLGLERKAFEEERASWLKQQFLNMTTFDHQNSENVKLFSAFSGSSDPDNLTVHSRPRQKKPHSVTNGAPACTSKLAKSLPASPSTSDICQTRSCVSEHRSSTNVLNIAPEETKANEIGRECTNQKWSVMSRPGSREGCYSGCSSTYTSSHLERDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G3ICE1</accession>
    <name>G3ICE1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pleckstrin homology domain-containing family M member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">Plekhm1</name>
        <name evidence="22" type="ORF">I79_021334</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7. May have a role in sialyl-lex-mediated transduction of apoptotic signals. Involved in bone resorption.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Autolysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH001912">
        <property type="protein sequence ID" value="EGW01692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512588.1">
        <property type="nucleotide sequence ID" value="XM_003512540.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027283847.1">
        <property type="nucleotide sequence ID" value="XM_027428046.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3ICE1"/>
    <dbReference type="STRING" id="10029.G3ICE1"/>
    <dbReference type="GlyGen" id="G3ICE1">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007635937.1"/>
    <dbReference type="GeneID" id="100766166"/>
    <dbReference type="KEGG" id="cge:100766166"/>
    <dbReference type="CTD" id="9842"/>
    <dbReference type="eggNOG" id="KOG1829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3ICE1"/>
    <dbReference type="OMA" id="TELCAPQ"/>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120281">
        <property type="term" value="C:autolysosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13321">
        <property type="entry name" value="PH_PLEKHM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17679">
        <property type="entry name" value="RUN_PLEKHM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000013">
        <property type="entry name" value="pleckstrin homology domain-containing family M member 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000315">
        <property type="entry name" value="pleckstrin homology domain-containing family M member 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042827">
        <property type="entry name" value="PLEKHM1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047326">
        <property type="entry name" value="RUN_PLEKHM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="21">
        <location>
            <begin position="40"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="19">
        <location>
            <begin position="539"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="992"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="272"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGW01692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027283847.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="117361" checksum="49314E03C131F631" modified="2011-11-16" version="1">MLSVENGLDPRAAIQVIKKKLVGSVKALQKQHVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAEAGGKRKKHTHQKPLPQPVFWPLLKAVTHKHIVSELEHLVFINTDVGRCRAWLRLALNDGLMECYLKLLLQEPTRLCEYYQPTALLRDAEEGEFLLSFLQGLTSLSFELSYKSAILNEWTLTPLSLSGLCPLSELDPLTTSGAELQRKESLDSISHSSGSEDIEVQHSGHKIRRNRKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSRSPDRSEEPMSYDSDLGPVNADDSDRSLQEVLSEFSKAQVNSVPSSGPSQETETSTFQTPLSLHSLATGTHVHLEGPAELLPAHASSGTPIGGYKHQLLPQETPDVQQLGTAQAAPAGSTSDQQPSGPVGGTAGQGSGQPKALQYGRIGPKLVVSSPTSPKNKCWISEDDFCRPPQKRVPKSSSDLSTSPLQGTPESRPALHRCFSQGPRKSCSLGALDKACVPSPGFGSAKAAPAAMLAQDHKNFCVVHRRQMGLSNPFRGLMKLGTVARRGAMGMWKEFFCELSPLELRLYLSDEERTCVESCSLLRCEAVGPAHGDGRFELVFSGKKLALRASSQDEAEDWLDRVREALQKVRPQQEDEWVNIQYPDQPEDVLEAPPDSLPSHSALLPEPAGAQGMQLDWTSAQVPEPDAIKESLLYLYADRTWVPYIFSLSLESLKCFRVRNNEKMLSDSHGVETIRDILPDTSLGGPAFFKIITAKAILKLQAKNTEEAALWRDLVRKVLASYLESAEEAVTLGGSLDENCQEVLKFATRENGFLLQYLVAIPTEKGLDSQGCFCAGCSRQIGFSFVRPKLCAFSGLYYCDFCHQDDASVIPARIIHNWDLTKRPVCRQALKFLAQIRAQPLINLQLVNASLYEHVERMHLIGRSREQLKLLGDYLGLCRSGALKELSKRLSHRNYLLESPHKFSVADLQQIAEGVYEGFLKALIEFASQHVYHCDLCTQRGFICQICHHHDIIFPFEFDTTVRCAECRTVFHQSCQAVVRKGCPRCARRRKYQEQNSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3II85</accession>
    <name>G3II85_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleus accumbens associated 2, BEN and BTB (POZ) domain containing</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8 12 13">Nucleus accumbens-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12 13" type="primary">Nacc2</name>
        <name evidence="8" type="ORF">I79_023553</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12 13">17A/GY</strain>
            <tissue evidence="12 13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH002952">
        <property type="protein sequence ID" value="EGW09449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278726.1">
        <property type="nucleotide sequence ID" value="XM_027422925.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278728.1">
        <property type="nucleotide sequence ID" value="XM_027422927.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035293691.1">
        <property type="nucleotide sequence ID" value="XM_035437800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3II85"/>
    <dbReference type="STRING" id="10029.G3II85"/>
    <dbReference type="GlyGen" id="G3II85">
        <property type="glycosylation" value="2 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007637230.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014645.1">
        <property type="protein sequence ID" value="ENSCGRP00001010424.1"/>
        <property type="gene ID" value="ENSCGRG00001012321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769059"/>
    <dbReference type="KEGG" id="cge:100769059"/>
    <dbReference type="CTD" id="138151"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159244"/>
    <dbReference type="OMA" id="QSFEQGP"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902231">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18289">
        <property type="entry name" value="BTB_POZ_BTBD14A_NAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2590:FF:000002">
        <property type="entry name" value="Putative nucleus accumbens-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000009">
        <property type="entry name" value="Zinc finger and BTB domain-containing 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF2">
        <property type="entry name" value="NUCLEUS ACCUMBENS-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BEN" evidence="7">
        <location>
            <begin position="349"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW09449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027278726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027278728.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="63422" checksum="C9E5EBE96CFBEE68" modified="2011-11-16" version="1">MSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGTVPPACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAMIEDASSEPQSPCNQLQPATAAYVASPSVPIPLLTRVKHEAMEMPPATGLGLASKRPLETGSRDGMAIATGAVGTPGTAPLKLPRVSYYGVPSLATLIPSIQQVPYPQGERTSPGASSLPTTDSPTSYHNEEDEEDDEAYDTMVEEQYGQMYIKATGNYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELVAGSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSFKESEMNVIAADMCTNARRVRKRWLPKIKSMLPEGVEMYRTVMGASAASLPLDPEFPPAASQVFEQRIYAEQRRSDAATIVALRTDAVNVDLSTSANPAFEASEEVDGAGSVIQEVAAPEPLPADGQSPPQAFEQGNTSSSRPQTPVATATRRPEGTYAGTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q9WU83</accession>
    <name>DPM1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber>2.4.1.83</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Dolichol-phosphate mannose synthase subunit 1</fullName>
            <shortName>DPM synthase subunit 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Dolichyl-phosphate beta-D-mannosyltransferase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Mannose-P-dolichol synthase subunit 1</fullName>
            <shortName>MPD synthase subunit 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPM1</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-01" db="EMBL/GenBank/DDBJ databases">
            <title>Mutation in B4-2-1 CHO cells defective in MPD synthase activity.</title>
            <authorList>
                <person name="Pu L."/>
                <person name="Scocca J.R."/>
                <person name="Walker B.K."/>
                <person name="Wu J.S."/>
                <person name="Krag S.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="EC" id="2.4.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="2">Binds 1 divalent metal cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; within the complex, directly interacts with DPM3. This interaction may stabilize DPM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83"/>
    <dbReference type="EMBL" id="AF121895">
        <property type="protein sequence ID" value="AAD30975.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233614.1">
        <property type="nucleotide sequence ID" value="NM_001246685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9WU83"/>
    <dbReference type="SMR" id="Q9WU83"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-NP_001233614.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00015029811">
        <property type="protein sequence ID" value="ENSCGRP00015024299"/>
        <property type="gene ID" value="ENSCGRG00015018497"/>
    </dbReference>
    <dbReference type="GeneID" id="100689420"/>
    <dbReference type="KEGG" id="cge:100689420"/>
    <dbReference type="CTD" id="8813"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153481"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000059169" description="Dolichol-phosphate mannosyltransferase subunit 1">
        <location>
            <begin position="2"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>GDP-alpha-D-mannose</name>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N-acetylalanine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O60762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q8U4M3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="266" mass="29654" checksum="4AFB37EA3AC3329D" modified="1999-11-01" version="1">MASPGASRGASAATAAAASPRPPQGRSSRRDKYSVLLPTYNERENLPLIVWLLVKSFSESSINYEIIIIDDGSPDGTREVAEQLEKIYGPDRILLRPREKKLGLGTAYIHGIKHATGNYVIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFITQILLRPGASDLTGSFRLYRKEVLQKLIEKCVSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061HVZ9</accession>
    <name>A0A061HVZ9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apolipoprotein E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC113837959</name>
        <name evidence="26" type="synonym">Apoe</name>
        <name evidence="23" type="ORF">H671_21218</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26 27">17A/GY</strain>
            <tissue evidence="26 27">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="20">Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
            <location evidence="2">Multivesicular body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Extracellular vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the apolipoprotein A1/A4/E family.</text>
    </comment>
    <dbReference type="EMBL" id="KE687467">
        <property type="protein sequence ID" value="ERE59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027286676.1">
        <property type="nucleotide sequence ID" value="XM_027430875.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289571.1">
        <property type="nucleotide sequence ID" value="XM_027433770.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061HVZ9"/>
    <dbReference type="GeneID" id="113837959"/>
    <dbReference type="KEGG" id="cge:100773810"/>
    <dbReference type="KEGG" id="cge:113837959"/>
    <dbReference type="OrthoDB" id="9048614at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042627">
        <property type="term" value="C:chylomicron"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034362">
        <property type="term" value="C:low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034361">
        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060228">
        <property type="term" value="F:phosphatidylcholine-sterol O-acyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055090">
        <property type="term" value="P:acylglycerol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045833">
        <property type="term" value="P:negative regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033700">
        <property type="term" value="P:phospholipid efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090181">
        <property type="term" value="P:regulation of cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090207">
        <property type="term" value="P:regulation of triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.20:FF:000002">
        <property type="entry name" value="Apolipoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.20:FF:000003">
        <property type="entry name" value="Apolipoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000074">
        <property type="entry name" value="ApoA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF2">
        <property type="entry name" value="APOLIPOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01442">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0162">Chylomicron</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0345">HDL</keyword>
    <keyword evidence="10" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="23" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0558">Oxidation</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0850">VLDL</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044539274" description="Apolipoprotein E" evidence="22">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="113"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="227"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ERE59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027286676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027289571.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35888" checksum="D83D8342B31A8A33" modified="2014-09-03" version="1">MKALWAVLVVTLLAGCLAEAELEPEVTEQLAWQSSQPWEQAMNRFWDYLRWVQTLSEQVQEELQTSQVTQELTVLMEDTMTEVKAYKKELEEQLGPMAEETRARLSKEVQAAQARLGADMEDLRNRLGQYRSEVQTMLGQSTEELRARFATHLRKLRKRLLRDAEDLQKRLAVYKAGAREGAERGVGAIRERLGPLVEQGRQRTASLGAGAAQPLRDRAQALGDRIRGRLEEVSNQARDRLEEVREQMEELRAKVEEQAQQMRLQAEIFQARLKGWFEPLVEDMQRQWANLVEKIQASVATSPIPTSVPKESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IBK7</accession>
    <name>A0A061IBK7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17 18 19 20" type="primary">Cd151</name>
        <name evidence="13" type="ORF">H671_3g9876</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with integrins ITGA3:ITGB1, ITGA5:ITGB1, ITGA3:ITGB1 and ITGA6:ITGB4 and with CD9 and CD181. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3. Interacts with ITGA3; this interaction modulates ITGA3 glycosylation pattern. Interacts with F11R. Interacts with RAC1 and CDC42; these interactions mediate physical association of RAC1 and CDC42 with integrin adhesion receptor complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="KE672658">
        <property type="protein sequence ID" value="ERE79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648613.1">
        <property type="nucleotide sequence ID" value="XM_007650423.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648614.1">
        <property type="nucleotide sequence ID" value="XM_007650424.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264730.1">
        <property type="nucleotide sequence ID" value="XM_027408929.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264731.1">
        <property type="nucleotide sequence ID" value="XM_027408930.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297992.1">
        <property type="nucleotide sequence ID" value="XM_035442101.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297993.1">
        <property type="nucleotide sequence ID" value="XM_035442102.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316582.1">
        <property type="nucleotide sequence ID" value="XM_035460691.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316583.1">
        <property type="nucleotide sequence ID" value="XM_035460692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IBK7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027672.1">
        <property type="protein sequence ID" value="ENSCGRP00001023426.1"/>
        <property type="gene ID" value="ENSCGRG00001021652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754541"/>
    <dbReference type="KEGG" id="cge:100754541"/>
    <dbReference type="CTD" id="977"/>
    <dbReference type="GeneTree" id="ENSGT00940000157760"/>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042098">
        <property type="term" value="P:T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044319">
        <property type="term" value="P:wound healing, spreading of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03155">
        <property type="entry name" value="CD151_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000005">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF487">
        <property type="entry name" value="CD151 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ERE79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027264730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027264731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035297992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035297993.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28350" checksum="B7B063C36D9D9734" modified="2014-09-03" version="1">MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLVLKSDYISLLASNTYLATAYILVVAGGVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMTKKYHQSGHKGVTNAVDKLQQEFHCCGSNNSQDWRDSEWIRSGEAENRVVPDSCCKTVVPGCGRRDHASNIYKVEGGCISKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7GS67</accession>
    <name>A0A3L7GS67_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PDZ and LIM domain protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Pdlim2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9. Interacts (via LIM zinc-binding domain) with MKRN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035308705.1">
        <property type="nucleotide sequence ID" value="XM_035452814.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315172.1">
        <property type="nucleotide sequence ID" value="XM_035459281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7GS67"/>
    <dbReference type="SMR" id="A0A3L7GS67"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023455.1">
        <property type="protein sequence ID" value="ENSCGRP00001019211.1"/>
        <property type="gene ID" value="ENSCGRG00001018717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768674"/>
    <dbReference type="KEGG" id="cge:100768674"/>
    <dbReference type="CTD" id="64236"/>
    <dbReference type="GeneTree" id="ENSGT00940000160418"/>
    <dbReference type="OMA" id="MRGHFWF"/>
    <dbReference type="OrthoDB" id="445995at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09449">
        <property type="entry name" value="LIM_Mystique"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06753">
        <property type="entry name" value="PDZ_PDLIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000085">
        <property type="entry name" value="PDZ and LIM domain 2 (mystique)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000130">
        <property type="entry name" value="PDZ and LIM domain 2 (mystique)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF1">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="14">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="282"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="125"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035308705.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="37798" checksum="83BAFB676FDBD56A" modified="2019-02-13" version="1">MPLTVDVVGPAPWGFRISGGRDFHTPIIVTKVTERGKAEAADLRPGDIIVAINGERAESMLHAEAQSKIRQSASPLRLQLDRSQPASPGQTNGDGSLEVLAARFQGSLRTHHDSQFSKRPAYFSQASLSPRPGSPFSTPPPTSPLAVSGEDVIGCSFQSLTHSPGPAATHHLSYPGHPTSQQASHSSTSNFTVRVPLHSPGPRSSSPRFSGLDLEEDSEVFKMLQENRQGRAAPRQSSSFRLLQEALEAEERGGTPAFVPSSLSSQASLPTSKALATPPKLHTCEKCSANISNQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGNELYCEKHARQRYSMPGTLSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HA40</accession>
    <name>A0A3L7HA40_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Large ribosomal subunit protein bL12m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">39S ribosomal protein L12, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Mrpl12</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with NOA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027281209.1">
        <property type="nucleotide sequence ID" value="XM_027425408.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HA40"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006369.1">
        <property type="protein sequence ID" value="ENSCGRP00001004272.1"/>
        <property type="gene ID" value="ENSCGRG00001005393.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755729"/>
    <dbReference type="KEGG" id="cge:100755729"/>
    <dbReference type="CTD" id="6182"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.710:FF:000006">
        <property type="entry name" value="39S ribosomal protein L12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 20" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="16">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="15">
        <location>
            <begin position="136"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027281209.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="21705" checksum="39DC4481E897BEAE" modified="2019-02-13" version="1">MLPAAAAAASRLWAPRLGLRGAALRLARQQVPGVCAARQLSSSSQRRSEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLMPMGGMMPGAVPAAAAAAPEVAEGEDIPKQKERTHFTVRLTEAKPVDKVKLIKEIKNYVQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HJM0</accession>
    <name>A0A3L7HJM0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Fmo4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="RefSeq" id="XP_035301485.1">
        <property type="nucleotide sequence ID" value="XM_035445594.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035313693.1">
        <property type="nucleotide sequence ID" value="XM_035457802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HJM0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011055.1">
        <property type="protein sequence ID" value="ENSCGRP00001007053.1"/>
        <property type="gene ID" value="ENSCGRG00001009519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753048"/>
    <dbReference type="KEGG" id="cge:100753048"/>
    <dbReference type="CTD" id="2329"/>
    <dbReference type="GeneTree" id="ENSGT00940000160256"/>
    <dbReference type="OMA" id="HYLKVWG"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046322">
        <property type="term" value="P:negative regulation of fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042178">
        <property type="term" value="P:xenobiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000042">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000073">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000183">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002256">
        <property type="entry name" value="Flavin_mOase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01124">
        <property type="entry name" value="FMOXYGENASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 17 18" id="KW-0274">FAD</keyword>
    <keyword evidence="5 17 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 17 18" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035301485.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="63327" checksum="46065B892E110435" modified="2019-02-13" version="1">MVKKVAVIGAGVSGLSSLKCCLDEGLEPTCFERSNDFGGLWKFGENSKDGMTRVYRSLVTNVCKEMSCYSDFPYQEDYPNFMDHEKFWEYLREFVEHFDLLKYIRFKTTVCSVTKRPDFSETGQWDVVIETEGKQDRAVFDAVMVCTGQFLNPHLPLESFPGIHKFKGQVIHSQEYRIPDAFQGKRIVVVGLGNTGGDIAVELSRTAAQVFLSTRTGTWVISRSSGGGYPFNMMITRRWCNFVAQVLPSYFINWDKKLHLNHENYGLRIAKGQKQKFIVNDELPTCILCGKITMKASIKDFTESSIIFEDGTIEANIDVVIFATGYEFSFPFFEEPLKSLCANKIMLYKRVFPPGLERTTLAIIGLISLTGSILAGTELQARWATRVFKGLCTIPPPQKLMAEATKKKELIKRGVIKETSQDKLNFISYMDEIAQCIGSKPNIPLLFIKDPRLAWEVFFGPCSPYQYRLMGPGKWDGARNAILTQWDRTIKPMKTRIVPESSEPASLSHYLKVWGTPLLLTSLILFYKSSLLLKLVQNKLQGRVFPNHILWFIPQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IB60</accession>
    <name>A0A3L7IB60_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Pim3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="RefSeq" id="XP_027252023.1">
        <property type="nucleotide sequence ID" value="XM_027396222.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IB60"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030380.1">
        <property type="protein sequence ID" value="ENSCGRP00001026134.1"/>
        <property type="gene ID" value="ENSCGRG00001023550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757447"/>
    <dbReference type="KEGG" id="cge:100757447"/>
    <dbReference type="CTD" id="415116"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061179">
        <property type="term" value="P:negative regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000209">
        <property type="entry name" value="Serine/threonine-protein kinase pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PIM-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="40"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="46"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027252023.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35927" checksum="F07FE297E4EF1BD1" modified="2019-02-13" version="1">MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKVYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGVAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHGCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWMLGTEGSVPENCDLRLCALDTDDGASTTSSSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IJ78</accession>
    <name>A0A3L7IJ78_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein FRG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">FSHD region gene 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Frg1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003497624.1">
        <property type="nucleotide sequence ID" value="XM_003497576.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246970.1">
        <property type="nucleotide sequence ID" value="XM_027391169.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IJ78"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018259.1">
        <property type="protein sequence ID" value="ENSCGRP00001014022.1"/>
        <property type="gene ID" value="ENSCGRG00001014998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770784"/>
    <dbReference type="KEGG" id="cge:100770784"/>
    <dbReference type="CTD" id="2483"/>
    <dbReference type="GeneTree" id="ENSGT00390000004552"/>
    <dbReference type="OMA" id="IEQWEPI"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23338">
        <property type="entry name" value="beta-trefoil_FSCN_FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000031">
        <property type="entry name" value="FRG1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF3">
        <property type="entry name" value="PROTEIN FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027246970.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29124" checksum="17235F9ACC607ACE" modified="2019-02-13" version="1">MAEYSFVKSTKLVLKGSKAKSKKKKSKDKKRKREEDEETQLDIVGIWWTVSNFGEISGTIAIEMDKGAYIHALDNGLFTLGAPHREVDEGPSPPEQFTAVKLSDSRIALKSGYGKYLGINSDGLVVGRSDAIGPREQWEPVFQDGKMALLASNSCFIRCNEAGDIEAKNKTAGEEEMIKIRSCAERETKKKDDIPEEDKGNVKQCEINYVKKFQSFQDHKLKISKEDSKILKKARKDGFLHETLLDRRAKLKADRYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LCL6</accession>
    <name>A0A8C2LCL6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 9">Keratin-associated protein 19-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">LOC113835384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with hair keratins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the KRTAP type 19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027269096.1">
        <property type="nucleotide sequence ID" value="XM_027413295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LCL6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001969.1">
        <property type="protein sequence ID" value="ENSCGRP00001001699.1"/>
        <property type="gene ID" value="ENSCGRG00001001560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113835384"/>
    <dbReference type="KEGG" id="cge:113835384"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021743">
        <property type="entry name" value="KRTAP_type8/19/20/21/22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051528">
        <property type="entry name" value="KRTAP_type_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38140">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 19-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38140:SF5">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 19-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11759">
        <property type="entry name" value="KRTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0416">Keratin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027269096.1"/>
        </source>
    </evidence>
    <sequence length="62" mass="6878" checksum="4FAFC3211AB748A5" modified="2022-01-19" version="1">MSFYSRYYGGLGYGYRGFGNLGYGCGCGCGYGRYGYGSGYGGYGYGYRRPLYYGGFGFSHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LPC8</accession>
    <name>A0A8C2LPC8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6 9">ALK and LTK ligand 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">LOC113833765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ALKAL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035295116.1">
        <property type="nucleotide sequence ID" value="XM_035439225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LPC8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009672.1">
        <property type="protein sequence ID" value="ENSCGRP00001006181.1"/>
        <property type="gene ID" value="ENSCGRG00001008308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113833765"/>
    <dbReference type="KEGG" id="cge:113833765"/>
    <dbReference type="GeneTree" id="ENSGT00940000159969"/>
    <dbReference type="OrthoDB" id="9807651at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030298">
        <property type="term" value="F:receptor signaling protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070378">
        <property type="term" value="P:positive regulation of ERK5 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029364">
        <property type="entry name" value="ALKL1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28676:SF1">
        <property type="entry name" value="ALK AND LTK LIGAND 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28676">
        <property type="entry name" value="ALK AND LTK LIGAND 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15129">
        <property type="entry name" value="ALKL1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678620" evidence="5">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035295116.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14237" checksum="C090C577799696B7" modified="2022-01-19" version="1">MWSAKPSARLPALLLLALALSPPGTHGRPRGRRAARPAELKSQLLLPVTGTRQAPRASRSAEIFPRDLTLKDKFIKHFTGPVTFSAECSKHFHRLYHNTRDCSMPAYYKRCARLLMRLAVSPLCSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LQC0</accession>
    <name>A0A8C2LQC0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC113830635</name>
        <name evidence="17" type="synonym">LOC100774806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027283207.1">
        <property type="nucleotide sequence ID" value="XM_027427406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LQC0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010439.1">
        <property type="protein sequence ID" value="ENSCGRP00001006627.1"/>
        <property type="gene ID" value="ENSCGRG00001008985.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cge:100774806"/>
    <dbReference type="OrthoDB" id="9602214at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15421">
        <property type="entry name" value="7tmA_OR2T-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
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    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="15">Liver</tissue>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="2 8">Belongs to the DAN family.</text>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035301973.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20680" checksum="90AC99749B1AD8F6" modified="2022-01-19" version="1">MNRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LW12</accession>
    <name>A0A8C2LW12_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ganglioside-induced differentiation-associated protein 2 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ganglioside-induced differentiation-associated-protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Gdap2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDAP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027249586.1">
        <property type="nucleotide sequence ID" value="XM_027393785.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310601.1">
        <property type="nucleotide sequence ID" value="XM_035454710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LW12"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014716.1">
        <property type="protein sequence ID" value="ENSCGRP00001010495.1"/>
        <property type="gene ID" value="ENSCGRG00001012369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771093"/>
    <dbReference type="KEGG" id="cge:100771093"/>
    <dbReference type="CTD" id="54834"/>
    <dbReference type="GeneTree" id="ENSGT00940000156336"/>
    <dbReference type="OMA" id="IHPTFWT"/>
    <dbReference type="OrthoDB" id="365077at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02905">
        <property type="entry name" value="Macro_GDAP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000006">
        <property type="entry name" value="ganglioside-induced differentiation-associated protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035793">
        <property type="entry name" value="Macro_GDAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF72">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="43"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027249586.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="56454" checksum="B24F3E04B94DBFE5" modified="2022-01-19" version="1">MDPLGAPSQFVDVDTLLSWGDSYKDELNSHDSTAETFQEDTIRSPFLYNRDINGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLKGCRTGEAKLTKGFNLAARFIIHTVGPKYKNRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGETIEKVVFAVSELEEATYQKLLPLYFPRSLREESQSLPYLPADIGNADGEPVVPERQIRISEKPGASEDNQEEDEDDGLGVDLSFIGSHAFARMEGDIDKQRKLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGLKDKIHHIDSLHQLFSAISPEQIDFPPFVLEYDARENGPYFASYPPSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M0Q1</accession>
    <name>A0A8C2M0Q1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC100761408</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027268036.1">
        <property type="nucleotide sequence ID" value="XM_027412235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M0Q1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014544.1">
        <property type="protein sequence ID" value="ENSCGRP00001010323.1"/>
        <property type="gene ID" value="ENSCGRG00001012246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761408"/>
    <dbReference type="KEGG" id="cge:100761408"/>
    <dbReference type="OrthoDB" id="9592089at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15405">
        <property type="entry name" value="7tmA_OR8B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="48"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027268036.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35711" checksum="B29C2EA5FC312139" modified="2022-01-19" version="1">MQPMKQMATESNSSSVTEFILMGLTVQPELQLPLFVLFLFNYTATVLGNLSLMNLICLNTHLHTPMYFFIFNLSCIDFCYSFVCTPKMLMNFVLEKNTISFRGCMSQLFFFCFFVNSECYVLTAMAYDRYVAICQPLQYTTVMSPMMCYLLMFGSYLMGFAGAMVHTGFMIRLNFCDSNIINHYMCDIFPLLQLSCSSTYVNELVSSAVVGTIIILSSLIILVSYAMILFNIIHMSSGKGWSKALGTCGSHIITVSLFYGSGLLAYVKPSSAKTVGQGKLFSVFYTLVVPMLNPLIYSLRNKDVKVAVKKTMKRIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M9I5</accession>
    <name>A0A8C2M9I5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Microsomal signal peptidase 22/23 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Spcs3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007648346.1">
        <property type="nucleotide sequence ID" value="XM_007650156.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027246844.1">
        <property type="nucleotide sequence ID" value="XM_027391043.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M9I5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016796.1">
        <property type="protein sequence ID" value="ENSCGRP00001012562.1"/>
        <property type="gene ID" value="ENSCGRG00001013944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753146"/>
    <dbReference type="KEGG" id="cge:100753146"/>
    <dbReference type="CTD" id="60559"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027246844.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20340" checksum="F72AB8E0F3F6D708" modified="2022-01-19" version="1">MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDKYEITKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M9Z4</accession>
    <name>A0A8C2M9Z4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Gins4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Associated with ORC2. Interacts with HELB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003503368.1">
        <property type="nucleotide sequence ID" value="XM_003503320.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251101.1">
        <property type="nucleotide sequence ID" value="XM_027395300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M9Z4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001020599.1">
        <property type="protein sequence ID" value="ENSCGRP00001016355.1"/>
        <property type="gene ID" value="ENSCGRG00001016717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752225"/>
    <dbReference type="KEGG" id="cge:100752225"/>
    <dbReference type="CTD" id="84296"/>
    <dbReference type="OMA" id="ILETAWI"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001833">
        <property type="term" value="P:inner cell mass cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000002">
        <property type="entry name" value="DNA replication complex GINS protein SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.60:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="11">
        <location>
            <begin position="73"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="12">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001016355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027251101.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25976" checksum="FF776B61A6091EA6" modified="2022-01-19" version="1">MTEVLDLHEQDSDGGSEEVVLTPAELIERLEQAWMNEKFAPELLESKPEIVECVMEQLEHMEGNLRRAKSGDLKVSIHRMEMERIRYILSSYLRCRLMKIEKFFPHILEKEKMRPAGEPSVLSPEEFVFVKEYMDHTETHLKNVALKHMPPNLQKVDLLRAVPKPDLDSYVFLRVKERQENILVEPEADEQRDYVIDLEEGSQHLIRYKTIAPLVASGAVQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MFH1</accession>
    <name>A0A8C2MFH1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Ube2d2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027256572.1">
        <property type="nucleotide sequence ID" value="XM_027400771.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MFH1"/>
    <dbReference type="SMR" id="A0A8C2MFH1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021935.1">
        <property type="protein sequence ID" value="ENSCGRP00001017691.1"/>
        <property type="gene ID" value="ENSCGRG00001017664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757523"/>
    <dbReference type="KEGG" id="cge:100757523"/>
    <dbReference type="CTD" id="7322"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027256572.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16735" checksum="C942BE7853CBC355" modified="2022-01-19" version="1">MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MGA3</accession>
    <name>A0A8C2MGA3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Junctional adhesion molecule A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Junctional adhesion molecule 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 25" type="primary">F11r</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
            <tissue evidence="25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with ITGAL (via I-domain). Interacts with CD151.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027274780.1">
        <property type="nucleotide sequence ID" value="XM_027418979.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027295454.1">
        <property type="nucleotide sequence ID" value="XM_027439653.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MGA3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021669.1">
        <property type="protein sequence ID" value="ENSCGRP00001017425.1"/>
        <property type="gene ID" value="ENSCGRG00001017471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764378"/>
    <dbReference type="KEGG" id="cge:100764378"/>
    <dbReference type="CTD" id="50848"/>
    <dbReference type="GeneTree" id="ENSGT00940000159186"/>
    <dbReference type="OMA" id="VEWKFVH"/>
    <dbReference type="OrthoDB" id="10031887at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ig_3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678858" description="Junctional adhesion molecule A" evidence="20">
        <location>
            <begin position="27"/>
            <end position="299"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="235"/>
            <end position="260"/>
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            <begin position="28"/>
            <end position="126"/>
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            <begin position="134"/>
            <end position="227"/>
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            <dbReference type="ARBA" id="ARBA00004251"/>
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        <source>
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    <sequence length="299" mass="32325" checksum="EAD951D5F3528450" modified="2022-01-19" version="1">MGTEGKAGRKLLFLFTSMVLGSLVQGSGSVYSSNTDVQVAENNPITLSCTYSGFSNPRVEWKFVQGGTTTLVCYNSQITASYADRVTFSSSGITFKSVTRKDTGEYTCMVSEDGGQNYGEVSIQLTVLVPPSKPTVNIPSSLTIGNRAVLTCSEQDGSPPSEYSWYRDGIDMLTDAKKTRAFVNSSYTVNPKTGDLIFDPVTAFDSGEYYCQAQNGFGTATRSEAVRMDAVELNVGGIVAAVLVTLILLGFLIFGIWFAYSRGYFERAKKGTAPGKKVIYSQPSARSEGEFKQTSSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MGS1</accession>
    <name>A0A8C2MGS1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NAD(P)H pyrophosphatase NUDT13, mitochondrial</fullName>
            <ecNumber evidence="5">3.6.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Nucleoside diphosphate-linked moiety X motif 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Nudt13</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP. Has a marked preference for the reduced pyridine nucleotides. Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11800"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:11801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90832"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:48869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NADPH + H2O = reduced beta-nicotinamide D-ribonucleotide + adenosine 2',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:90832"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:60821"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="5"/>
    <dbReference type="RefSeq" id="XP_003509549.1">
        <property type="nucleotide sequence ID" value="XM_003509501.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243394.1">
        <property type="nucleotide sequence ID" value="XM_027387593.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MGS1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001022452.1">
        <property type="protein sequence ID" value="ENSCGRP00001018208.1"/>
        <property type="gene ID" value="ENSCGRG00001018032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761096"/>
    <dbReference type="CTD" id="25961"/>
    <dbReference type="GeneTree" id="ENSGT00940000158879"/>
    <dbReference type="OMA" id="PGQTEIH"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000059">
        <property type="entry name" value="Nucleoside diphosphate-linked moiety X motif 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11383:SF3">
        <property type="entry name" value="NAD(P)H PYROPHOSPHATASE NUDT13, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11383">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="20">
        <location>
            <begin position="196"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001018208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027243394.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39161" checksum="F9CAF1D9E0FBDF40" modified="2022-01-19" version="1">MSLYCGTICRRKSFWCYRLLSTYVTKARYLFELKEDDEACRKALQTGVFYLFHDLAPLLQASGHRYLVPRLSRAELEGLLGKFGQDSQRIEDSVLIGCSNQQEAWFALDLGLNSAASKHVSLPKSEMEAELGGSFIKLRQALFQLNSMDSSLLFTAQALLRWHDGHQFCSKSGQPTKKNMAGSKRVCPSSNIIYYPQMAPVVITLVTDGARCLLARQSSFPKGLYSALAGFCDIGESVEEAVRREVAEEVGLEVESLQYSSSQHWPFPNSSLMIACHATVKAGQTEIQVNQKELEAAAWFSLDEVATALLRKGSFLQQQSDALPLLLPPKLAIAHHMIKKWVERQTCASLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MP24</accession>
    <name>A0A8C2MP24_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein Wfdc21</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WAP four-disulfide core domain 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">LOC100771328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035304228.1">
        <property type="nucleotide sequence ID" value="XM_035448337.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317203.1">
        <property type="nucleotide sequence ID" value="XM_035461312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MP24"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025907.1">
        <property type="protein sequence ID" value="ENSCGRP00001021663.1"/>
        <property type="gene ID" value="ENSCGRG00001020449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771328"/>
    <dbReference type="KEGG" id="cge:100771328"/>
    <dbReference type="GeneTree" id="ENSGT00520000060616"/>
    <dbReference type="OMA" id="WDCGPGE"/>
    <dbReference type="OrthoDB" id="9621563at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050872">
        <property type="term" value="P:white fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678947" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035304228.1"/>
        </source>
    </evidence>
    <sequence length="63" mass="6712" checksum="D84DD8754637FDC6" modified="2022-01-19" version="1">MKLGAFLLMVSLIAFSLEVQELQAAVRPLQLLGTCAELCRGDWDCGEGEQCVSTGCSNICTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MSN1</accession>
    <name>A0A8C2MSN1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Integrin alpha 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="24">Integrin alpha-3 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Itga3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Membrane</location>
            <topology evidence="2 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007642673.1">
        <property type="nucleotide sequence ID" value="XM_007644483.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280089.1">
        <property type="nucleotide sequence ID" value="XM_027424288.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MSN1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027260.1">
        <property type="protein sequence ID" value="ENSCGRP00001023015.1"/>
        <property type="gene ID" value="ENSCGRG00001021353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758471"/>
    <dbReference type="CTD" id="3675"/>
    <dbReference type="GeneTree" id="ENSGT00940000157746"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031527">
        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N0T8</accession>
    <name>A0A8C2N0T8_CRIGR</name>
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        </submittedName>
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        </submittedName>
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        <name evidence="12 15" type="primary">Vwa7</name>
    </gene>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027244607.1">
        <property type="nucleotide sequence ID" value="XM_027388806.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027296617.1">
        <property type="nucleotide sequence ID" value="XM_027440816.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N0T8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031070.1">
        <property type="protein sequence ID" value="ENSCGRP00001026824.1"/>
        <property type="gene ID" value="ENSCGRG00001024017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770280"/>
    <dbReference type="KEGG" id="cge:100770280"/>
    <dbReference type="CTD" id="80737"/>
    <dbReference type="GeneTree" id="ENSGT00390000011517"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056475">
        <property type="entry name" value="GBD_Hemicentin/VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057615">
        <property type="entry name" value="Ig_VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057613">
        <property type="entry name" value="VWA7_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056862">
        <property type="entry name" value="VWA7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23560">
        <property type="entry name" value="GBD_Hemicentin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23619">
        <property type="entry name" value="Ig_VWA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23610">
        <property type="entry name" value="VWA7_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25107">
        <property type="entry name" value="VWA7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679087" evidence="6">
        <location>
            <begin position="26"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="VWA7 N-terminal" evidence="11">
        <location>
            <begin position="81"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Hemicentin-1-like von Willebrand factor A" evidence="10">
        <location>
            <begin position="313"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Hemicentin/VWA7 galactose-binding" evidence="7">
        <location>
            <begin position="507"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="VWA7 beta-sandwich" evidence="8">
        <location>
            <begin position="600"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="VWA7 Ig-like" evidence="9">
        <location>
            <begin position="724"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027244607.1"/>
        </source>
    </evidence>
    <sequence length="888" mass="95694" checksum="F0C52C6628E2A5BF" modified="2022-01-19" version="1">MGAPLTHLGPPILLLLQLLPLPTFAFFPNIWSLLAAPGSVTHQDLTEEAALNVTLQLFLDRPSPGRPRLRLEDYRGRTLLADDIFAAYFGPGSPSRRFRAALGEVSRANAAQDFLPASRNNPDLHFDAERLVQGRTLLVGALRETLVAATAFESALARQRLGAALHALQDFYSHSNWVELGKQQPHPHLLWPRPELWSLAQVGDPTCSDCEELSCPGNMLDFTLLTSGYFGTHPPKPRGKCSHGGQFDQSSSQPPRGGINKDSTSPSFSPHHTLHLQAAEVALLASIQVFSLLRSRLGDRGFSRLLDITPASSLSFVLDTTGSMGEEINAAKIQARRIVEQRQDSPMEPTSYVLVPFHDPGFGPVFTTSDPDSFWQKLNEIHALGGGDEPEMCLSALELALMHTPPLSDIFVFTDASPKDTFLTNRVESLTRERRCRVTFLVTEDPSRVQGRVRREVLSPLRFEPYEAIALASGGEVIFTKDQHIQDVAAIVGESMAGLVTLPLEPPVFAPGETCVFTVDRLLRQVTVRIHGDISSFWIKSPAGVSQGPEEGIGPLGHTRRFGQFWTVTMTDPPQTGSWEMQVAAEGTPRVRVQAQTSLDFLFHFGIPVEDGPHPGLYPLTQPVAGLQTQLLVEVTGLVSRHNPEDGQPHFSHVVLRRVPEGTHLGRVPLEPVGPPERGLLAASLPPTLLSIAAPFSLELAGQDGGGQGLRRTAPQPCAVAPVLLELSGPPASLAPGSKAPLSLHVASFSGPQDLDLRTSVNPRFSLTSNLSRAHLGLNESAWGRLWLEVPDSAAPDSVVMVTVTALGQGASPVPPTHAFLRLLVLASPSQGPMASPAHSAGRVLPPAASTPLPSPSVIRARAGEGTVSTSWWGTVAGVLFLLDCSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N0V9</accession>
    <name>A0A8C2N0V9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTPase IMAP family member 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">GTPase, IMAP family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">LOC100764847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304908.1">
        <property type="nucleotide sequence ID" value="XM_035449017.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311031.1">
        <property type="nucleotide sequence ID" value="XM_035455140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N0V9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031168.1">
        <property type="protein sequence ID" value="ENSCGRP00001026922.1"/>
        <property type="gene ID" value="ENSCGRG00001024093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764847"/>
    <dbReference type="KEGG" id="cge:100764847"/>
    <dbReference type="OMA" id="HKGAHYS"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF74">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035304908.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33616" checksum="99EC305138C91785" modified="2022-01-19" version="1">MGGRKMARDEEIIYGLEEDSPGPRVPQLRLILVGKTGTGKSATGNSILGQKCFLSKLGAVPVTRACSRANRRWAGWYVEVVDTPDVFSSEVLKTDPACIETARCFLLSSPGPHALLLVTQLGRFTTEDCQALAGVKRVFGEQVMARTVVVFTRKEDLAGESLQDYVRCTDNRALRELVAQCGGRVCALNNRATGQELEAQAEQLLGLVAHLVREHGGTCYSNEVYDLVKTLRGADPQDQLTNVAEMVATRMQRPLHTRLLTGLWEWQKSYRKGWRRGVAIFLGVAFLIYLAYRKMPVGDQDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2NB25</accession>
    <name>A0A8C2NB25_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase MARCHF7</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Membrane-associated RING finger protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Membrane-associated RING-CH protein VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase MARCHF7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Marchf7</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_027276164.1">
        <property type="nucleotide sequence ID" value="XM_027420363.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310456.1">
        <property type="nucleotide sequence ID" value="XM_035454565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2NB25"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031833.1">
        <property type="protein sequence ID" value="ENSCGRP00001027585.1"/>
        <property type="gene ID" value="ENSCGRG00001024547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769757"/>
    <dbReference type="CTD" id="64844"/>
    <dbReference type="GeneTree" id="ENSGT00530000063836"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097371">
        <property type="term" value="F:MDM2/MDM4 family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043518">
        <property type="term" value="P:negative regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902166">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901799">
        <property type="term" value="P:negative regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905524">
        <property type="term" value="P:negative regulation of protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902916">
        <property type="term" value="P:positive regulation of protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002643">
        <property type="term" value="P:regulation of tolerance induction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16812">
        <property type="entry name" value="RING_CH-C4HC3_MARCH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000108">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052297">
        <property type="entry name" value="RING-CH-type_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471">
        <property type="entry name" value="MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="19">
        <location>
            <begin position="544"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="158"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="297"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="361"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022786"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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            <dbReference type="ARBA" id="ARBA00022990"/>
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            <dbReference type="ARBA" id="ARBA00060147"/>
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            <dbReference type="ARBA" id="ARBA00069013"/>
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            <dbReference type="ARBA" id="ARBA00084030"/>
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    <evidence type="ECO:0000256" key="18">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="19">
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            <dbReference type="PROSITE" id="PS51292"/>
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            <dbReference type="Ensembl" id="ENSCGRP00001027585.1"/>
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            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027276164.1"/>
        </source>
    </evidence>
    <sequence length="697" mass="76988" checksum="D4ED119E8FC955D7" modified="2022-01-19" version="1">MESKPSRIPRRISVQPSGSLSARMVSGNRGASLNDSYHSRDSSFRLDSEYQSASASASASPFQSTWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTSTSAGRNIGSGLNTVSDSSWRHSQVPRSSSMVLGSFGTDLIRERRDLERRADSSISNLMDYNHRSGDFTTSSYVQERVPSSYSQGARPKENSMSTLQLNSSSTNHQLPSEHQTVSSSRDSSRNSFRSHFSPRQSQSFRNSSHPTFSYLSSRDETPIISNSERVGSSRRPFQESSDNDGRRSTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSENYISPRTLTSQSRSSGASSSEVNDGRASEASQGFRFLRRRWGLSSLSQNHSSEPDAENFNQESEGRSTGPWLSSSLRNRCTPLFSRRRREGRDESSRISPSDVPPRSHIFRRESNEVVHLEAQSDPLGAAANRPQASGASSSAAGGSPPDLPQGGRSTGIAGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNAADGKSDKTKSAPSRDPEKLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTIEPSTRVRFINLARTLQAHMEDLETVISQILLSFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QIX7</accession>
    <name>A0A8C2QIX7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Chromodomain helicase DNA binding protein 9</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="21 22 23">Chromodomain-helicase-DNA-binding protein 9 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 21 22 23 24 25 26 27 28" type="primary">Chd9</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007619187.1">
        <property type="nucleotide sequence ID" value="XM_007620997.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007619195.1">
        <property type="nucleotide sequence ID" value="XM_007621005.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007619211.1">
        <property type="nucleotide sequence ID" value="XM_007621021.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016824191.1">
        <property type="nucleotide sequence ID" value="XM_016968702.3"/>
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        </source>
    </evidence>
    <sequence length="2880" mass="323760" checksum="2D9914CFD194E082" modified="2022-01-19" version="1">MTDPMMDFFDDTNLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSMKFHQVNQSFGSPAEHVLSPHSQFNCSPIHPQNQANGLFQDVADGSPMWGHQTATGLSNQNGSPFHQQGHSHSLHQSKSFVVHHDFALFQASEHQTQCTSLRSQQNRSNLNPGQNSLGQSKNFIDINVSGPHRVNANHPPHITNTSPSQQSLSVHFSQAANPPVHFLKCGSHQEGNFNRPSPSMTSCSVSNAQQFPAHCSFSSGHVSPSSLLQSSAVLAPSHTNQALSDFAGSNSFSPHRGIKQESAQHILNPTPSLNSNNFHILHSSHPQGNYSNSKLSPVHMSFPDPVDSGPPMGHFNDHVETNGFSSLEENLLHQVESHTEPFTGLDPEDLLQEGLLPQFDETTFGQDNSNHVLDHDLDRQFTSHLVARPSDMAQTQLQYQARSWPSSLSNHQHLHNRNHLCLQRQPPSSKKNDGSGTYTKLQNTQVRVMSEKKPRKKVESESKQEKANRIISEAIARAKERGERNIPRVMSPENFPSASVEGKEEKRGRRMKSKPKDRDNKKTKTCSKLKEKTKIGKLIITLGKKQKRKNESSDEPSDAEQLSQHTFKDQHSQKRRSNRQIKRKKYAEDAEGKQSEEEVKGTIKTKKNSAPLPGEQPLQLFVENPSEEDAAIVDKILSSRIVKKELSPGVMLDVEEFFVKYKNYSYLHCEWATEQQLLKDKRIQQKIKRFKLRQAQRAHFLADMEEEPFNPDYVEVDRILEVSFCEDKDTGESVIYYLVKWCSLPYEDSTWELKEDVDLAKIEEFEQLQSSRPDTRHLDRPPSNIWKKIDQSREYKNGNQLREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWTDINVVVYHGSLISRQMIQQYEMYFRDSQGRIIRGAYRFQAIITTFEMILGGCGELNAIEWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKKLAPKEETIIEVELTNIQKKYYRAILEKNFSFLSKGAGQTNVPNLVNTMMELRKCCNHPYLIKGAEEKILGEFRDTYNPSASDFHLQAMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRCLDILEDYLIHKRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQNKAVKVYRLVTRNSYEREMFDRASLKLGLDKAVLQSMSGRDGTVSGIQQLSKKEIEDLLRRGAYGAIMEEEDEGSKFCEEDIDQILLRRTKTITIESEGRGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAEIDIDAISGRNSLVIDTPRIRKQTRPFSATKDELAELSEAESEGEEKPKLRRPCDRSGYGRTECFRVEKNLLVYGWGRWREILSHGRFKRQLNEQDVEIICRALLAYCLVHYRGDEKIKGFIWDLITPTEDGQTRELQNHLGLSAPVPRGRKGKKVKTQTSSFDIQKAEWLRKYNPEQLLQDEGYKKHVKHHCNKVLLRVRMLYYLKQEVIGNECQKVFDGVDASDIDVWVPEPDHSEVPAVWWDFDADKSLLIGVFKHGYEKYNTIRADPALCFLERVGKPDDKAVAAEQRANDYMDGDVEDPEYKPAPAIFKDDIEDDVSSPGDLIIADGDGQLMEGDKVYWPTPSALTTRLRRLITAYQRTNKNRNIQQIQPTFSVPANVMQPVYEEVTLNPKMAAKIERQQRWTRREEADFYRVVSTFGVVFDPDRGQFDWTKFRAMARLHKKTDNSLEKYLYAFMSMCRRVCRLPSKEELVDPNIFIQPITEERASRTLYRIELLRKVREQALRHPQLFERLKLCHPNPDLPIWWECGPHDRDLLIGAAKHGVSRTDYHILRDPELSFMAAQRNYSQSKVAHSRTCAPLLQQYQAALSASPLTSLPRLLDAKSTLLEDVKVKNENLKEESSEEESMSSVETRTRVKSEPVSPKNGVLPQATGDQKSGGKSDTDRRMVAARTEPLTPNPASKKQRVHKRGSESSSDSDSDSERSSCSSRSSSSSSSSSCSHSRSGSSSSSSSSCSSASSSSSSSSSSSSSSSSEESDSEEEVQKREGAPHVKAYDEESVASLSTTQDETQDSFQANNGTPESAYLLQGGYMLAASYWPKDRVMINRLDSICQTVLKGKWPSARRNYDANTVASFYTTKLLDSPGAATEYSEPSVPTPPAVAVKEDHEQSTQMSKVKKHVREKEFTVKIKDEGGLKLTFQKQGLAQKRPFDGEDGALGQQQYLTRLRELQSASETSLVNFPKSMPASGTSIQSTLGANGVILDNQPIVKKRRGRRKNVEGVDILFLNRNKPPNHLSTGINPALSYTQPQRIPDTESPVPVINLKDGTRLAGDDAPKRKDLDRWLKEHPGYVEDLGAFIPRVQLHEGRPKQKRHRCRNPNKLDVNSLTGEERVQLINRRNARKVGGAFAPPLKDLCRFLKENSEYGVAPEWGDVVKQSGFLPESMYERILTGPVVREEVSRRGRRPKSGISKATIAATAPASSVPGNPLLTNGLLPGVDLTALQALQQNLQNLQSLQVTAGLMGMPAGLSSGGETKNMAAMFPMLLSGMAGLPNLLGMGGLLSKTTESGAEEKKGNDSKELEGKKERTESQSSENGGESCVSGSPSTSSTAALSPAAAAKPIALNPLLLSNILYPGMLLTPGLNLHIPTLSQPSTFDVQKNKNSDLGSSKSVGIKEEASRVRDQEEKGGTEPSPFNENSTDEGSEKASSGSDSTSSSSEDSDSSNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EXU0</accession>
    <name>A0A9J7EXU0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LOW QUALITY PROTEIN: DNA-directed RNA polymerase III subunit RPC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Polr3d</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027246001.1">
        <property type="nucleotide sequence ID" value="XM_027390200.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100767520"/>
    <dbReference type="KEGG" id="cge:100767520"/>
    <dbReference type="CTD" id="661"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027246001.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44366" checksum="A7A5F97853B476C9" modified="2023-06-28" version="1">MSEGNAAGEPSNPGGPRPLLSGVXGADHRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTPNIISRKIKEEPKEEVTMKKEKRERDRDRQREGHGRGRGRPEVIQSHSIFEQGPAEMMKKKGNWDKTVDMSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFIDDPGLKNDTRNMPVQLPLAHSGWLFKEESEEPDVKPFSAGPKEEDMEVDVPSVKVKEEPRDEEEEAKVKAPPKAARKTPGLPKDVSVAELLRELSLSKDEELLFLQLPDTLPGQPPTQDIKPIKTEVQGEDGQMVVIKQEKDREARLAENACTLADLTEGQVGKLLIRKSGKVQLLLGKVTLDVTMGTTCSFLQELVSVGLGDSRTGEMTVLGHVKHKLVCSPDFESLLDHKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EYJ7</accession>
    <name>A0A9J7EYJ7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UDP-glucose:glycoprotein glucosyltransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">UDP--Glc:glycoprotein glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">UDP-glucose ceramide glucosyltransferase-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Uggt1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer as well as in a tight complex with SELENOF. Interacts with METTL23. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027242683.1">
        <property type="nucleotide sequence ID" value="XM_027386882.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100773968"/>
    <dbReference type="KEGG" id="cge:100773968"/>
    <dbReference type="CTD" id="56886"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000004">
        <property type="entry name" value="UDP-glucose glycoprotein glucosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF3">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="16">
        <location>
            <begin position="68"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="17">
        <location>
            <begin position="322"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="18">
        <location>
            <begin position="461"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="19">
        <location>
            <begin position="733"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="20">
        <location>
            <begin position="1266"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027242683.1"/>
        </source>
    </evidence>
    <sequence length="1555" mass="177732" checksum="DC0A8FDF7D4232C9" modified="2023-06-28" version="1">MHASPIHYGPELYPWLGLAELALVLRLLPGFCYNMGLLIVLASLCLFSLVEANSKAITTSLTTKWFSAPLLLEASEFLAEDSQEKFWSFVEASQNIGSSDHHDSEHSYYNAILEAAFQFLSPLQQNLLKFCLSLRSYSASIQAFQQIAVDEPPPEGCKSFFSVHGQQTCDFDSLETLVLTAPDRPKPLLFKGDHRYPSSNPESPVVIFYSEIGHEEFSNIHYQLKSKSKEGKINYVFRHYISNPRKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTDVNTTVIGENDPIDEVQGFLFGKLRELYPNLEGQLKEFRKHLVESTNEMAPLKVWQLQDLSFQTAARILAAPVELALVVMKDISQNFPTKARAITKTAVSSQLRTEVEENQKYFKGTIGLQPGDSALFINGLHIDLDTQDIFSLFDTLRNEARVMEGLHRLGIEGLSLHNILKLNIQPSETDYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIVDPVHETTAELISIAEMFLSNHIPLRIGFIFVVNDSEDVDGLQDAGVAVLRAYNYVVQEVDGYHAFQTLTHIYNKVRTGEKVKVEHVVSILEKKYPYVEVNSILGIDSAYDQNRKDARGYYEQTGVGPLPVVLFNGMPFEKEQLDPDELETITMHKILETTSFFQRAVYLGELPHDQDVVEYIMNQPNVVPRINSRILTAKREYLDLTASNNFFVDDFARFSSLDSRGKTAAIANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKTSNNVRISMINNPSQEISYSNTPIFRAIWAALQTQTSNSAKNFITKMAKEETAEALAAGVDIGEFSVGGMDVSLFKEAFESSKMDSILSHALYCRDVLKLKKGQRVVISNGRIIGPLEESELFNQDDFHLLENIILKTSGQKIKSHIQQLQVEEDVASDLVMKVDSLLSAQPKGEARIDYQFFEDKHSAIKLKPNEGDTYYDVVAVVDPVTREAQRLAPLLLVLTQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTADNSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDNVVTAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPTIVDTIVMANLGYFQLKANPGAWILRLRKGRSDDIYRIYSHDGTDSPPDANEVVVILNNFKSKIIKVKVQKKADMVNEDLLSDGTNENESGFWDSFKWGFSGQKTEEVKQEKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMASKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQILFQKEKEQERTQRPQKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F3E6</accession>
    <name>A0A9J7F3E6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING finger protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Rnf17</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-associates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027246317.1">
        <property type="nucleotide sequence ID" value="XM_027390516.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100753029"/>
    <dbReference type="KEGG" id="cge:100753029"/>
    <dbReference type="CTD" id="56163"/>
    <dbReference type="OrthoDB" id="5800423at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20414">
        <property type="entry name" value="Tudor_TDRD4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20415">
        <property type="entry name" value="Tudor_TDRD4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20416">
        <property type="entry name" value="Tudor_TDRD4_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20417">
        <property type="entry name" value="Tudor_TDRD4_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20418">
        <property type="entry name" value="Tudor_TDRD4_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000114">
        <property type="entry name" value="RING finger protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047845">
        <property type="entry name" value="RNF17-like_TUDOR_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047847">
        <property type="entry name" value="RNF17-like_TUDOR_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047848">
        <property type="entry name" value="RNF17-like_TUDOR_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047849">
        <property type="entry name" value="RNF17-like_TUDOR_rpt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047850">
        <property type="entry name" value="RNF17-like_TUDOR_rpt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="18">
        <location>
            <begin position="722"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="18">
        <location>
            <begin position="956"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="18">
        <location>
            <begin position="1216"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="18">
        <location>
            <begin position="1466"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1137"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1137"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027246317.1"/>
        </source>
    </evidence>
    <sequence length="1610" mass="182529" checksum="6213629D10FA663A" modified="2023-06-28" version="1">MAAEASTAGFTASCAHIVGSKSGPLDASECQCTRCGRTVSVVSGHHHELQCGHIFCEQCLLVTQEYTTSKCPDCEVHTTVSMNQGHYSIDGFLKEDSSLEALQPKMVKNCSSGVKKTVDQLIVDLEHSSSIHRTVLSPSAIMSETEEIDEALKIAGYNFEQLSNAIKMLDSTQNQTREETHSLTEVVEKQFDKLLASLDSRKKSLCEELVRRTDDYLSKLATVKSYIEEKKNDLDAAMKIAKELKSAPSLRTYCDLTQIIRTLKLTFESELSQVNSIIPRNPPRLNINCSEIVCMFNSMGKIEFEGSTKCYPQENEVGQNVQKKFNNKKELCCDAYSSLDKKRVDATVLAGEAPVPPLQPETPDKHLEGKSKQPQKEMAVVTSPKTIAVLPQLGSSPDVIIEEIIEENLECCPELVFVSHVIHPCNFYVRKYSQIKDATVLEKKMKQVCNKCLHLDPSDILELGARIFVNSIENRMWCRGIITEIIPTKTKNIRKPCCPTKFSVCEISLIQIFMVDFGNSEVLIITGVGDTHMRPEHVGEQHITLNDFCLLLRKSEPYSEELLKDIPPLAHLCSLKDIVPYNSSEGWEKEAKVEFLKMVNNKAVLMKVFGEDDEVLIVDLQKPPTNKISSDMPVSLRDALVFMELARFRSQSPRSHSEKNTLCYHPPILPEEMTEVSVMVCHINSPTDFYLQWMENLDFLSLLKTIEEFYKGEDGENLEILCPVQDQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLDPPEKAIKCKLAYIEPSKRTQWSKKAKEKFEEKTQDKFVTCSVIKILENNELLVELFDSRAPGATAISINDQLVKEGLASYEAGYTLKDNSKKHLEVWDPSPEEIISSEINSLSPLSVKSLPNENFQSLYNKELPVNICNVISPEKIYVQWLLTENLLTSLEEKMTAAYEHSEWKPVRWERDMHCAVKVPAKSQWRRGQIIRMVTDTLVEVLLYDVGVELVVNITCLRELQENLKTTGRLSLECSLVDIRPTGGSDKWTATACDCLSLYLTGAIATIILQENSTTWPLPVKIFCRDEKGERVDVSKYLIKKGLALRERRISKSNNSHSPEKSLEIPLEQGDSIVTKCFTINFDTNKKTADNTNEHKVPGSKEKKSETRTTSYKPPAIPNTNAFEAVVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYFWKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYQTSPVGNVWQPDAIELLQELLSKREVDIHIMELPENPWGKLSVHLYFDGMSLSYFMAHHKYCIFEHSEDIFKEKPIGQNKKYEEENWKIRFEELLLPEMEAPILPPYLSSLLPPPEELYAVQVKHIVSPDEVYICLDSVESCTQFNHPGDTDDSGICWESESENLEEALQRFNKNVETFPPLTDFSSEMPCLAEYADGLWYRAKIVSIKEFNPLSVLVLFVDYGSTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPPLSDSGKARIPYCPKWSMEALWTMIDCLQGKQLYASSVAQAPEQIVTLYEDERYPVHMSLVELGLADKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F5T2</accession>
    <name>A0A9J7F5T2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein monoglycylase TTLL8 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ttll8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamyl-[protein] + glycine + ATP = glycyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:17207"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:167890"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67181"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003509602.1">
        <property type="nucleotide sequence ID" value="XM_003509554.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027251808.1">
        <property type="nucleotide sequence ID" value="XM_027396007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F5T2"/>
    <dbReference type="GeneID" id="100754335"/>
    <dbReference type="KEGG" id="cge:100754335"/>
    <dbReference type="CTD" id="164714"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000032">
        <property type="entry name" value="tubulin monoglycylase TTLL3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF3">
        <property type="entry name" value="PROTEIN MONOGLYCYLASE TTLL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027251808.1"/>
        </source>
    </evidence>
    <sequence length="833" mass="95452" checksum="09D708316A857785" modified="2023-06-28" version="1">MTCPLIPDLSSRPPSHTLGLRNLPLNPWVCLTSPPLSAGPGGQRNQLHEAIMENGERKKLSSTSLDEDQKEDNKLKQGIPQDLSSSPKLDRYKIARQLTEKAIKEKKIFSIYGHYPVIRATLRRKGWVEKKFHFLPKILQNVEGEDNKNSETKENQEIPLERLDDIHDVMSRLVKNEMPYLLWTIKRDVVDYHSLSCEQMLNHYGKTASFTTKIGLCLNMRSLPWYVQANPNTFFPRCYGLCTESEKQEFLDDFRRTVASSILKWVVSHQNYYSKIKSKSKKEEAKNGDPNPPKDPDDTDKFQGLSGQLVDTACKVCHAYLGQLEHEDIDKSETSTEALSEEEWNDLTKQYYLLVHGNAFISDSRSYFSQCQALLSKISSVNPQTDIDGIRNIWIIKPAAKSRGRDIVCMDRVENILELVATDNQTSKDNKWVVQKYIETPMLIYDTKFDIRQWFLVTDWNPLTIWFYKESYLRFSTQRFSLDKLDSAIHLCNNSIQRRLKNDKERSPLLPGHNMWTSTRFQEYLQKRGRGGTWGSIIYPSMKRAVTNAMRVAQDHVEARKNSFELYGADFILGRDFKPWLIEINSSPTMHPSTPVTAQLCAQVQEDTIKVVVDRKLDRNCDIGNFELLWRQPAVELPPFNGSDLCVEGISVKKAKKQMPPITNLSFSDSLSDTPIKVRSPRALPDPAVGFSRTTLRQDWKREEAKVLSATWSVPVMADEGKCQAKPDYTFPFSNYQHGDSKAPQSTFTRVQSTKHLDPNLISIHQPALVLQNMKTMERPQSPPPEASSGNCGEPVPFCPFIFEGFQLYPNLRRRPSSCILQSRAQGWIRGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F651</accession>
    <name>A0A9J7F651_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein misato homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Msto1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003501626.4">
        <property type="nucleotide sequence ID" value="XM_003501578.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248982.2">
        <property type="nucleotide sequence ID" value="XM_027393181.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F651"/>
    <dbReference type="GeneID" id="100753624"/>
    <dbReference type="KEGG" id="cge:100753624"/>
    <dbReference type="CTD" id="55154"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="8">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="9">
        <location>
            <begin position="163"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027248982.2"/>
        </source>
    </evidence>
    <sequence length="575" mass="62740" checksum="6A7770EADAC0CF92" modified="2023-06-28" version="1">MGAGPAPWAPEALSGVLRSGAAMAGGAREVLTLQLGHFSGFVGAHWWNQQDAALGRTTEGEESPGELCPDVLFRTGRTLHGQETYTPRLILMDLKGSLNSLKEEGGLYKDRHPDTTVAWQGKLTTHREEAYPKNPNLQDLLSAEGVLSTDGVWRAKPIENGKENIIRVWSDFLRVHLHPRSICVIQKYNHDGETGRLEAFGQGESVLKEPRYLEELEDRLHFYVEECDYLQGFQILCDLHDGFSGVGAKTAELLQDEYSGRGVITWGLLPGPCNLGEPQKNIYRLLNTAFGLVHLTGYSSLVCPLSLGGNLGLRPKPPVNFPNLHYDATLPFHCSAILATALDTVTAPYRLCSSMVPMAHLADLLSFSGKKVVTAEAIIPFPLVPGQSLPDTLVQLEGDTPWTPLSACGDSAGSQCFAQSVVLRGIDRASHTSNLNPGTPLPSGLHTCASGEEVLAQYLQHQHPRVLSSSHLLRTPCRVAPPYPHLFSSCSYKGMALDCPPKCAAVQSIPVFGALRSSSSLHQTLGDLAEELNRLDLRRWASFMDAGVEQDDMEELLQDLYNLAQCYQEGVSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FAH1</accession>
    <name>A0A9J7FAH1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Kinesin-like protein KIF21A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Kif21a</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027252127.1">
        <property type="nucleotide sequence ID" value="XM_027396326.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100766958"/>
    <dbReference type="CTD" id="55605"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22263">
        <property type="entry name" value="Rcc_KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000233">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000370">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000011">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056533">
        <property type="entry name" value="KIF21A/B_hel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF31">
        <property type="entry name" value="KINESIN FAMILY MEMBER 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23204">
        <property type="entry name" value="KIF21A_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 20" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="24">
        <location>
            <begin position="9"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="1333"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="1612"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="552"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="829"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1162"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="379"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="637"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="929"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="587"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1103"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1185"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1211"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1234"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1277"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027252127.1"/>
        </source>
    </evidence>
    <sequence length="1664" mass="185619" checksum="B4332E639A45EA45" modified="2023-06-28" version="1">MLGVADESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYTQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQGIISRAVKHLFKSIEEKKNTAIKNGVPPPEFKVNAQFLELYNEEVLDLFDTTRDIDAKNKKSNIRIHEDSTGGIYTVGVTTRTVNTEPEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDAENATDNKMISESSQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRARITQLVSDQANQVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARSSYFSGSSAFSPSILTSDKETIEIIDLAKKDLEKLKRKEKKKKKSVAGKEENADTDQEKKEEKGISEKENNGLEVEDNQEGSDHEEEEEEEEEEDEEDDDMEGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVKCEYEKKLHAMNKELQRLQTAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDSPVQDTGSSAAGEAEASRAGTQQKMRIPVARVQALPTPTTNGTRNKYQRKGLTGRVFTSKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLRQREELTKRREKLSKRREKIVKESGEGDKNVVNIIEEMESLTANIDYINDSIADCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSAPVENEEDSSDEDAPLHSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSAGDASLPGSLTPVAEGQEIGMNTETSGTSARDKELLPPSGLPSKIGSISRQSSLSEKNLPEPSPVTRRKAYEKADKAKVKEHKHSDSGASETSLSPPSSPPSRPRNELNVFNRLTVSQGNTSVQQDKSDESDSSLSEVHSRSSRRGIINPFPASKGIRTSSLQCVHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGVHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRESAKCIRTLTSSGQVTLGEACSASSSRTVAIPSGESQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISNGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLAQKGLLQQVPNAHKDWVCALGLVPGHPVLLSGCRGGILKLWNVDTFVPVGEMRGHDSPINAICVNSTHVFTAADDRTVRIWKAHNLQDGQISDTGDLGEDIASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FCV7</accession>
    <name>A0A9J7FCV7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 201 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Tmem201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM201 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027254081.1">
        <property type="nucleotide sequence ID" value="XM_027398280.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FCV7"/>
    <dbReference type="GeneID" id="100769513"/>
    <dbReference type="KEGG" id="cge:100769513"/>
    <dbReference type="CTD" id="199953"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005521">
        <property type="term" value="F:lamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040041">
        <property type="entry name" value="TMEM201"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018861">
        <property type="entry name" value="TMEM201_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28646">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28646:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10476">
        <property type="entry name" value="DUF2448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 201 C-terminal" evidence="10">
        <location>
            <begin position="191"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027254081.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="72363" checksum="CEB33ED913EB9BD7" modified="2023-06-28" version="1">MEGVSALLASYPTAGLAGGLGITACAAAGVLLYRIARRVKPTHTVVNCWFCNQDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYMEHLNHVVSGAPSPRDPTQPQQWVSSQVLLCRRCSHHQTTKIKQLAAFTPREEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFRRREVDQAHGQSLSSSAMRAPFQVILLRALAFLACAFLLSTTLYGPSEPFTTGAVLPPALPPGGNSSAASDNTTTQAEGWQQLLSLLPAHTTEKLHEAWAFGQSHQTGIVAGGLLTCLLAMILAGRIRLRRIDAFSTCLWALLLGLHLAEQYLQAASPSWLDTLKLSTTSLCCLVGFTAAVATRKATGPRRFRPRRYFSGDSASLFPSSPSLAMPCPSITTSPASLFIPTPPGFLPLTKQQLFRSPRRVSPSSLPGRLNRALSLGTIPSLTRTDSGYLFSGSRPPSRVSPPGEVSLSDYFSLLSSSFPAPPLASPAPSVASSMASSSGSLRHRRPLISPARLNLKGQKLLLFSPPGEAPNTPSSSEEHLTPNGSLFIEPPQLPQRNCTRDTKHNMDMRSMLARDGAACSSHSIKKEDDSSQSSACVVDTTTKGCSEETAPWKAPVGPSLVRGLLAVSLAINALFTSAYLYQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FL47</accession>
    <name>A0A9J7FL47_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100763142</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262634.1">
        <property type="nucleotide sequence ID" value="XM_027406833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FL47"/>
    <dbReference type="GeneID" id="100763142"/>
    <dbReference type="KEGG" id="cge:100763142"/>
    <dbReference type="OrthoDB" id="6144223at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15417">
        <property type="entry name" value="7tmA_OR5A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="42"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027262634.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35543" checksum="DF285B04CC9E0D6F" modified="2023-06-28" version="1">MIVGRNITQITQFVLLGFADFPQIIALLFVMFLTLYITALTWNLSLLVLIRMDSHLHTPMYFFLSNLSFVDLCYITSTVPKMLSNFFQEKQTISFGGCIIQYFIFSTMALTECCLMTAMAYDRYAAICKPLLYSSIMSPTLCARMVMGSCTAGLLGSLSQMCALLKLHFCGPNVIRHFFCDISQLLNLSCTDTFFAQVLLALLTMLFGLTNALVIMTSYGFIVLSIMKITSAKGRSKAFNTCASHLTAVSFFYISGIFVYLRSSSGGSSSFDRFTSVFYTVVIPMLNPLIYSLRNKEIKDSMKRMQKKTFCSQGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FL93</accession>
    <name>A0A9J7FL93_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synaptogyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Syngr1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the synaptogyrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027259840.1">
        <property type="nucleotide sequence ID" value="XM_027404039.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316352.1">
        <property type="nucleotide sequence ID" value="XM_035460461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FL93"/>
    <dbReference type="GeneID" id="100774700"/>
    <dbReference type="KEGG" id="cge:100774700"/>
    <dbReference type="CTD" id="9145"/>
    <dbReference type="OrthoDB" id="10041611at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF7">
        <property type="entry name" value="SYNAPTOGYRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011282">
        <property type="entry name" value="Synaptogyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027259840.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25602" checksum="A2A7C45129527F5C" modified="2023-06-28" version="1">MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWVFSIVVFGSIVNEGYLNNSDKEEEFCIYNRNPNACSYGVTVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSGFWAFFWFVGFCFLANQWQVSKPQDNPLNEGTDAARAAIAFSFFSIFTWAGQAVLAFQRYQIGADSALFSQDYMDPSQDSSMPYAPYVEPSAGTDPAGMGGTYQHAANAFDAEPQGYQSQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FQ48</accession>
    <name>A0A9J7FQ48_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oocyte-secreted protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC113834784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PLAC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262637.1">
        <property type="nucleotide sequence ID" value="XM_027406836.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FQ48"/>
    <dbReference type="GeneID" id="113834784"/>
    <dbReference type="KEGG" id="cge:113834784"/>
    <dbReference type="OrthoDB" id="9450704at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033222">
        <property type="entry name" value="PLAC1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14380:SF8">
        <property type="entry name" value="OOCYTE-SECRETED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14380">
        <property type="entry name" value="PLACENTA-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039930873" evidence="5">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027262637.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13818" checksum="A6BEB5500D19CD81" modified="2023-06-28" version="1">MKAFVSSGLLLLLIAWIWRCLGQQPVSVECSYLMLRVIAKRALFYPDELVHPNELFLGTGCVVTFIRPDEFEFYYSVRLCGIVIEIVPDRTIFNTWLTYKPRNLCASAELQLECVIPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FR95</accession>
    <name>A0A9J7FR95_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Chmp1a</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003495127.2">
        <property type="nucleotide sequence ID" value="XM_003495079.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266417.1">
        <property type="nucleotide sequence ID" value="XM_027410616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FR95"/>
    <dbReference type="GeneID" id="100762678"/>
    <dbReference type="KEGG" id="cge:100762678"/>
    <dbReference type="CTD" id="5119"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027266417.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28112" checksum="7C2A7F08DB581D74" modified="2023-06-28" version="1">MATACRARRTEAPPKAQLRLLARVSRATGNISDPGSPPGHSWSVRSRPLRRPEGCTTRLAMDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALQQKNVECARVYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSAMDLQKVSAVMDRFEQQVQNLDVHTSVMEDSVSSATTLTTPQEQVDSLIVQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FTA0</accession>
    <name>A0A9J7FTA0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BRISC complex subunit Abraxas 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Abraxas2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FAM175 family. Abro1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027264940.1">
        <property type="nucleotide sequence ID" value="XM_027409139.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FTA0"/>
    <dbReference type="GeneID" id="100770738"/>
    <dbReference type="KEGG" id="cge:100770738"/>
    <dbReference type="CTD" id="23172"/>
    <dbReference type="OrthoDB" id="6358435at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23524">
        <property type="entry name" value="Abraxas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023240">
        <property type="entry name" value="BRISC_Abraxas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023238">
        <property type="entry name" value="FAM175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31728">
        <property type="entry name" value="ABRAXAS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31728:SF1">
        <property type="entry name" value="BRISC COMPLEX SUBUNIT ABRAXAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21125">
        <property type="entry name" value="MPN_2A_DUB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02053">
        <property type="entry name" value="BRISCABRO1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02051">
        <property type="entry name" value="PROTEINF175"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MPN" evidence="15">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="345"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="236"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027264940.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48005" checksum="4D4C674E006B8EAD" modified="2023-06-28" version="1">MMGEVEISIMAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQIIHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLGIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQKKNEKEQERRLQQALLSRQMPSDNLEPAFSPRMSYSGFAAEGRSTLADTEPSDPPPPYSDFHPNNQESTLSHSHMERSVFMPRPQAVGSSNYASTSAGLKFSGSGADLLPSQRAAGDSGEESDDSDYENLIDPAESPHSEYSHSKNSRPVTHPDEDPRNTQTSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FTW6</accession>
    <name>A0A9J7FTW6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Trehalase</fullName>
            <ecNumber evidence="4 11">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Treh</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4 11"/>
    <dbReference type="RefSeq" id="XP_003510565.3">
        <property type="nucleotide sequence ID" value="XM_003510517.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267776.2">
        <property type="nucleotide sequence ID" value="XM_027411975.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FTW6"/>
    <dbReference type="GeneID" id="100759542"/>
    <dbReference type="KEGG" id="cge:100759542"/>
    <dbReference type="CTD" id="11181"/>
    <dbReference type="OMA" id="RYWDASD"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000034">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039928166" description="Trehalase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027267776.2"/>
        </source>
    </evidence>
    <sequence length="579" mass="65914" checksum="E5D4C7E28568D791" modified="2023-06-28" version="1">MLKVSWELHLLLLLGLGLRSQEALPPPCESQIYCHGELLHQIQMAKLYQDDKQFVDMSIATSPDEVLQSFSELAVAYNHSIPRGQLQEFVQRHFQPVGQELEPWVPEDWKDSPQFLQKISDAKLRAWAEQLHQIWKRLGKKMKPEILSYPERFSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVETYGHIPNGGRVYYLQRSQPPLLTLMMDLYVTHTKDVSFLQENIGTVASELDFWTVNRTITVNSGGRSYNLNRYYVPYGGPRPESYSKDADLANTVPEGDREALWTELKAGAESGWDFSSRWLVGGPNPDSLSSIRTSKMVPVDLNAFLCQAEGLMSNFYSRLGNDTEATKYRNLRSQRLAAMEALLWDEQKGAWFDYDLEKGKKNLEFYPSNLTPLWTGCFSDPSVIDKALKYLEDNQILTYQYGIPTSLRNTGQQWDLPNAWAPLQDLVIRGLAKSDSPRTREVAFQLAQNWIRTNFKVYSQTSAMYEKYDISNGGHPGGGGEYEVQEGFGWTNGLALVLLDHYGDQLTSGTQLASLGPHCLVAALLISLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G557</accession>
    <name>A0A9J7G557_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC100774976</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cell membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276744.1">
        <property type="nucleotide sequence ID" value="XM_027420943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G557"/>
    <dbReference type="GeneID" id="100774976"/>
    <dbReference type="KEGG" id="cge:100774976"/>
    <dbReference type="OrthoDB" id="9440149at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15412">
        <property type="entry name" value="7tmA_OR5M-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 14 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027276744.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34912" checksum="CA4A4C69F28997E7" modified="2023-06-28" version="1">MTSLNHTTGMDFILVGLTDSLVLGRILFVVFLLIFIITVAGNLCMIVLIRTNSHLQTPMYFFLGHLSFVDICYSSNVTPNMLHGFISEHKTITYAGCFTQCLLFIALVITEFYILASMALDRYVAICSPLHYSTRMSKNICVSLVTFPYVFGFLNGLSQTLLTFQLSFCGSREINHFYCADPPLIMLACSDTQVKKMAMFVVAGFTLSSSLTIILLSYLYIFAAILRIHSVEGRQKAFSTCGSHMTTVTIFYGTLFCMYLRPPSEKSVEESKVIAVFYTFLSPMLNPLIYSLRNKDVINAMKQMIKGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G561</accession>
    <name>A0A9J7G561_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein unc-79 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Unc79</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027274981.1">
        <property type="nucleotide sequence ID" value="XM_027419180.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027295520.1">
        <property type="nucleotide sequence ID" value="XM_027439719.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100765551"/>
    <dbReference type="KEGG" id="cge:100765551"/>
    <dbReference type="CTD" id="57578"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1803"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1803"/>
            <end position="1820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027274981.1"/>
        </source>
    </evidence>
    <sequence length="2508" mass="281142" checksum="B6036C701BE311F9" modified="2023-06-28" version="1">MISTLATFPPFLHKDIIEYLSTSFLPMAILGSSRRESVPAHVNLSASAMLMIAMQYTSNPVYHCQLLECLMKYKQEVWKDLLYVIAYGPSQVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWNPIHCQHIECHNAINKPAVKMCIDPSLSVALGDKPPPLYLCEECSQRIAGDHSEWLIDVLLPQAEISAICQKKNCSSHVRRAVVTCFSAGCCGRHGNRPVRYCKRCHSNHHSNEVGATAETHLYQTSPPPINTRECGAEELVCAVEAVISLLKEAEFHAEQREHELNRRRQLGLSSSHHSLDNADFDNKDDDKHDQRLLSQFGIWFLVSLCTPSENTPTESLARLVAMVFQWFHSTAYMMDDEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCLLPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVISQSVWECIMPEWLEAIRTEVPDNQLKEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSTVQEQALLWLHVLSELDITVPLQLLISMFSDGVNSVKELANQRKSRTNELSGNNAARRVSVTSDPGRRGQHNVLSPFHSPFQSPFRSPMRSPFRSPFKNFGHPGGRTIDFDCEDDDMNLNCFILMFDLLLKQMELQDDGITMGLEHSLSKDIISIINNVFQAPWGGSHSCQKDKKAKECNLCQSSILCYQLACELLERLAPKDESRLVEPTDSLEDSLLSSRPEFIIGPEGEEEENPASKHGENPGTRTAPSEHAAIKNDTERKFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNCLKILCLHGECLYTARKDHPQFLAYIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADIFWTIINSNFNSKDWKTRFEAVEKVAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLDFQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLDCNKEFPFPTTITAVRTNVANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPAESKRALSLPETLTSKIRQQSPENDNTIKDLLPEDAGIDHQTVHQLITVLMKFMAKDESSAESDISSAKAFNTVKRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCPQLRHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDVSKILLHLIHITVNTLNAQYHSCKPHATAGPLYSDNSNISRYSEKEKEEDSVFDESDIHDTPTGPCNKESQTFFARLKRIGGSKMVKYQPVEMNVQRSEIELAEYRETGALQDSVLHCVREESIQKKKLRSLKQKSLDIGNADSLLFTLDEHRRKSCIDRCDIDKPPAQAAHISQRQNDHHGRSRQNSATRPDNAEIPKNPVTEGFQETRRPVIPEVRLNCMETFEVRVDSPGKPAPKEDLDLIDLSSDSTSGPEKHSILSTSDSDSLVFEPLPPLRIVESDEEDEMMNQGNDGPLGKNAASSPSIPSQPSVLSLSTTPLVQVSVEDCSKDFSSKDSGNHQSTSNDDSTITALDDLTDSEELSKSEEPREFASGSPLTLKQKRDLLQKSSAVPEMSVDYNPDLSPTEEKAGQTPTSGAKTVLLKLPEDAENPIEGEKPNASAESDTEQNPERKVEEDGAEESEFKIQIVPRQRKQRKIAVSAIQREYLDISFNIVDKLGDHKDPDPSAKGLSTLEMPRESSSAPTLEAGAPETGSHSSISTQYRQMKRGSLGVLTMSQLMKRQLEHQSSAPHNISNWDTEQVQPGKRQCNVPMCLNPDSDGQPLRTRGATKSSLLSAPSIASMFVPAPEEFTDEQPTVMTDKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDLAAPLLLDIMQSVGRLASSTTFSNQAESMMVPGNAAGVAKQFLRCIFHQLAPNGIFPQLFQSAIKDGTFLRTLATSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCLENIATFMEALPMDSPSSLWATISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLKIPSTNATRSLLEPFSKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKSPLPDTNLLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAAMECIRQYVSEVLDFMADMHTLTKLKSHMKTCSQPLHEDTFGGHLKVGLAQIAAMEISRGNHRDNKAVVRYLPWLYHPPSAMQQGPKEFIECVSHIRLLSWLLLGSLTHNAVCPNASSPCLPIPLDAGSHIADHLIVILIGFPEQSKTCVLHMCSLFHAFIFAQLWTVYCEQSAVATNVQNQNEFSFTAILTALEFWSRVTPSILQLMAHNKVMVEMVCLHVISLMEALQECNSTIFVKLIPMWLPMIQSNTKHLSAGLQLRLQAIQNHVNHHSLRTLPGSGQSSASLAALRKWLQCTQFKMAQVEIQSSEAASQFYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G6W9</accession>
    <name>A0A9J7G6W9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secretion-regulating guanine nucleotide exchange factor isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Sergef</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027276336.1">
        <property type="nucleotide sequence ID" value="XM_027420535.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G6W9"/>
    <dbReference type="GeneID" id="113836303"/>
    <dbReference type="KEGG" id="cge:113836303"/>
    <dbReference type="CTD" id="26297"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="288"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="355"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027276336.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="49227" checksum="C3A3DB5A68D76D70" modified="2023-06-28" version="1">MCMAHKSCVSEADSAAAAAALFAWGANSYGQLGLGHKEDVLLPQRLSNFCEPGCIKSVTGGGGHSAAVTDGGSLFVCGLNKDGQLGLGHTEDVLCFTICKPLLGCPIRQVACGWDFTIMLTEIGQVLSCGSNAFGQLGVPHGPRRCVVPQAVELLREKVVCVAAGLRHALATTVSGSVFQWGTGLASSGRRLCAGQTLPLFLTAKEPSRVMGLEDSTAVCVVAGSDHSASLTDTGELYVWGRNKHGQLASLAAFLLLPQRIDARCFQDEKVTAVWSGWTHLVAQTETGKVFTWGRADYGQLGRRLESPEGQKPHKQDSQLTFWRPQSSVSLPLCCLTGAAKISCGSEHNLAVISDKCFSWGWNEHGMCGDGTESNVWTPSPVQALQSPSRILLVGCGAGHSLALCQLPALSEPCQDVKVIYTLQAATGNPESQNGMNKERNRKERQSVTSTQSNSDRTRNEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G9E3</accession>
    <name>A0A9J7G9E3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RING-type E3 ubiquitin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Mgrn1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="RefSeq" id="XP_027279781.1">
        <property type="nucleotide sequence ID" value="XM_027423980.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G9E3"/>
    <dbReference type="GeneID" id="100772863"/>
    <dbReference type="KEGG" id="cge:100772863"/>
    <dbReference type="CTD" id="23295"/>
    <dbReference type="OrthoDB" id="10014838at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043951">
        <property type="term" value="P:negative regulation of cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045744">
        <property type="term" value="P:negative regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16816">
        <property type="entry name" value="mRING-HC-C3HC5_MGRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase MGRN1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MGRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="442"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027279781.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="63511" checksum="FC77A69D16A7E502" modified="2023-06-28" version="1">MGSILSRRIAGVEDIDIQANSAYRYPPKSAGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGEKPRVLYSLEFTFDADARVAITIYCQAVEEFLNGMAVYSCKNPSLQSETVHYKRGVSQQFSLPSFKIDFSQWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHVDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSSECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPISFSPVLAQSVDHDEHSCPFKKTKSHPASLASKKPKRETSSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEVTYSGISDGLSQASCPLVGLDRIIESGLQKGKPQSKSPDSTLRSPSSPIHEEDEEKLSEDSDAPLPPSGVELALRESSSPESFGTEEVDEPSLNQGSRVPSIDDVLQDGSPQHHGCSQQVPPADIYLPGWSTSMETPHSLGTTSSPWPLLSGSSSEPGATELTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G9V5</accession>
    <name>A0A9J7G9V5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">Asap2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027241219.2">
        <property type="nucleotide sequence ID" value="XM_027385418.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280494.1">
        <property type="nucleotide sequence ID" value="XM_027424693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G9V5"/>
    <dbReference type="GeneID" id="100759382"/>
    <dbReference type="KEGG" id="cge:100759382"/>
    <dbReference type="CTD" id="8853"/>
    <dbReference type="OrthoDB" id="435430at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08849">
        <property type="entry name" value="ArfGap_ASAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07642">
        <property type="entry name" value="BAR_ASAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13251">
        <property type="entry name" value="PH_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11966">
        <property type="entry name" value="SH3_ASAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000002">
        <property type="entry name" value="arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000004">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.950:FF:000001">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000006">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000012">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000012">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035677">
        <property type="entry name" value="ASAP2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037844">
        <property type="entry name" value="PH_ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF4">
        <property type="entry name" value="ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854">
        <property type="entry name" value="ASAP FAMILY MEMBER"/>
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    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
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    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="305"/>
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        <location>
            <begin position="287"/>
            <end position="300"/>
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        <location>
            <begin position="767"/>
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    </feature>
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            <begin position="878"/>
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    <sequence length="1001" mass="111097" checksum="FBBA11233D5420D2" modified="2023-06-28" version="1">MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINVSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKVKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQLRQSTAYSLHQPQGNKEHGTERNGNLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPSEDSVKPNPGSDMIARKDYITAKYIERRYARKKHADTSAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDVDEKLQPSPNRREDRPISFYQLGSSQFQPNAVSLARDTANLTKDKQRGFGPSILQNETYGAILSGSPPSSQSLPPSTTSAPPLPPRNVGGKVQTATSANTLWKTNSVGVDGVSRQRSSSDLPAVHPPLPPLRVTSTNPLTTTPPPPVAKASGTLDGVNQPSKPAQPGASQSKPPLLPPQPPSRLPQKKPASGTDKPTPLINKGQPRGPEAPGPLSNAMALQPPAPMPRKSQVTKSKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPSRKGAFPVSFVHFIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GDB9</accession>
    <name>A0A9J7GDB9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ovarian cancer-associated gene 1 protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Dph1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase. Interacts with DPH2. Interacts with RBM8A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="RefSeq" id="XP_003507319.1">
        <property type="nucleotide sequence ID" value="XM_003507271.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282558.1">
        <property type="nucleotide sequence ID" value="XM_027426757.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GDB9"/>
    <dbReference type="SMR" id="A0A9J7GDB9"/>
    <dbReference type="GeneID" id="100765648"/>
    <dbReference type="KEGG" id="cge:100765648"/>
    <dbReference type="CTD" id="1801"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027282558.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="47771" checksum="7265D9E6DCA03B47" modified="2023-06-28" version="1">MAALVVSETAEPGSRVGPGRGRISRGRLANQIPPEILNNPQLQAAVQALPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTKAEVMVMGDVTYGACCVDDFTARALGVDFLVHYGHSCLVPMDTSVQDFRVLYVFVDIRIDTAHLLDSVRLTFAPGSSLALVSTIQFVSTLQAAAQELKAEYHVSVPQCKPLSPGEILGCTSPRLPKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQATRQEAIAAARSAKTWGLILGTLGRQGSPKILEHLESRLKGLGLPFVRLLLSEIFPSKLSLLPMVDVWVQVACPRLSIDWGSAFPKPLLTPYEAAVALKDISWQQPYPMDFYAGNSLGPWTVNHGRDPGPRGLGQPASGKVQQGFRGQSPAPACEGCSCADLKAALPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GDS4</accession>
    <name>A0A9J7GDS4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ptrh1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes. Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes. Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:54449"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="RefSeq" id="XP_027279580.1">
        <property type="nucleotide sequence ID" value="XM_027423779.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314825.1">
        <property type="nucleotide sequence ID" value="XM_035458934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GDS4"/>
    <dbReference type="GeneID" id="100760505"/>
    <dbReference type="KEGG" id="cge:100760505"/>
    <dbReference type="CTD" id="138428"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1470:FF:000003">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027279580.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23290" checksum="993968C05D3549C2" modified="2023-06-28" version="1">MLRSGLFRSGMRRSWALRQRVSEARSPGKRWLVAGLGNHGMPGTRHSVGMAVLGQIARRLGVAESWARDPRCAADLALAPLGDAQLVLLRPRRLMNVNGRSVAQAAKLFGLTAEEIYLVHDELDKPLGKLSLKLGGSARGHNGVRSCICCLNSSAMPRLRVGIGRPTNPSMVPDYVLGYFSPEEQELLSPLLDQATDLLLDHIRARSQEPPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJ78</accession>
    <name>A0A9J7GJ78_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC113837633</name>
        <name evidence="15" type="synonym">LOC113838146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15">17A/GY</strain>
            <tissue evidence="14 15">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_027288331.1">
        <property type="nucleotide sequence ID" value="XM_027432530.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289737.1">
        <property type="nucleotide sequence ID" value="XM_027433936.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJ78"/>
    <dbReference type="GeneID" id="113837633"/>
    <dbReference type="KEGG" id="cge:113837633"/>
    <dbReference type="KEGG" id="cge:113838146"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027288331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027289737.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21428" checksum="BE81AEB1EE60BEAA" modified="2023-06-28" version="1">MTEYKLVVVGADGVGKTALTIQLIQYHFVDVYDPTIEDSYRKQVEIDGEICHLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAMNNTKSFEAIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLAGSYGIPFIETSAKTRQGVDDAFYTLVQEIRNHKEKMSKDGKKKKKKSKTKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GLY2</accession>
    <name>A0A9J7GLY2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC113838428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative pheromone receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289925.1">
        <property type="nucleotide sequence ID" value="XM_027434124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113838428"/>
    <dbReference type="KEGG" id="cge:113838428"/>
    <dbReference type="OrthoDB" id="9606139at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016503">
        <property type="term" value="F:pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000033">
        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027289925.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34945" checksum="E6BFF7C810D6D9F8" modified="2023-06-28" version="1">MYFWTLIIKIIFLSLTTIGILGNFSVFHYYVVCYADCKLKSADLIHLHLMASNTLIILSKGVPHTMAVFGXEQFLNDIQCRLILYIERVGRSVSIGSTCLLSVFQAITISQKETCCKDQKFKDAKYIGCSISLLWVLYILIHFILLVNPLIKRSSNNVTGKQDFGHCSIEGRDGINESLYAALVVCPEICFSLLMVWSSSSMIVILYRHKQRVQHIHSTHGSSRTSPESRATQNILALVSTFLAFYTVSAILQGCVALLSNPSWWLVNINHITFLCFPCFGSFVLINHYSMVSRLSLVWMRNINSLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMR8</accession>
    <name>A0A9J7GMR8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NACHT, LRR and PYD domains-containing protein 4 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Nlrp4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NLRP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027286667.1">
        <property type="nucleotide sequence ID" value="XM_027430866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GMR8"/>
    <dbReference type="GeneID" id="100773662"/>
    <dbReference type="KEGG" id="cge:100773662"/>
    <dbReference type="CTD" id="147945"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08320">
        <property type="entry name" value="Pyrin_NALPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000056">
        <property type="entry name" value="NACHT, LRR and PYD domains-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000442">
        <property type="entry name" value="NACHT, LRR and PYD domains-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004020">
        <property type="entry name" value="DAPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF6">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02758">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM01289">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50824">
        <property type="entry name" value="DAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pyrin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="9">
        <location>
            <begin position="146"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027286667.1"/>
        </source>
    </evidence>
    <sequence length="980" mass="112215" checksum="82E3F0C5F41DE232" modified="2023-06-28" version="1">MASFFSDFGLMWYLKELNKKEFMKFKEVLRQEIAESGLQHIPWNEVKKASREHLANLLVKHYEQKAWDVTFRIFQNINRKDLSERAAEEMAGHSKMYQAYLKNMLSHDWSRKFKIAIECFGNEDLTQDNCSRLWNLFVPKANEKPHTVLLIGMSGVGKTVFLAQLMRAWSEGLMFQNEFSYVFYLCCHEIKQLKTASLADLLSREWPRPSAPIAEIVSQPAKLLFIIDSLEGLNCDWSEPESELCDNWMQKCPVSILLSSLLRRKLLPESSLLITATPEAFEKLGDRIEYTVKNFVTGFNENSRRSCFQRVFQDEDTAQEVFTLVRENEQLYNICHVPSLCWMVATCLNDEVKRGGHLSAVCRCTTSVFAAYVLNLFIPQSAHYPSKKSQALLRGLCSVAAEGMWTDNFAFNQKDLEKNGVFHSDISTLLNMKILLKSRDSKNLYTFFHPSIQEFCAALFYLVNSHVDHPSKDVLCVETLLFTFLKKVRVQWIFLGSFIFGLLHKSEQAKLEAFFGYQLSQEVKQMLCQSLEKISADKELRKQIDDMKLFYCLFELEDDGFVTQVMTFLPQIKFVAKEYSDLIVAAYCLKNCSTLQNLSISTQDILWKENDPIYLRKLLLRWQDLCSVLGSSEQIQVLQVKDTYLDELAFLELYNHLKNPRCAPQTFQVNNVTLWYNQLFFELLTQNHNLHHLDLSLTCLSHSDVKLLYDALNQEECHIEELLLSGCQLSHDDCIIFASILISSKKLRHLNVSYNNLDKGMYLLSKALCHPDCVLKDLVLASCSLSKQCWNYLSDVLKRNKTLSHLDVSSNDLQDEGLKVLCQALSLPDSALKSLFLRRCLITSSGCQYLAEVLSSNQNLISLQVSNNKLEDAGVKLLCEAIKEPNCRLENLGLEACELTGASCEYLVSALSQNETLWAINLLKNALDLRGLAMLFEALNVHGCSPNVLGLQITIPDKETQELLIAEKEKNPYLAILSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMV8</accession>
    <name>A0A9J7GMV8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-Ala-His dipeptidase isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Cndp1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294637.1">
        <property type="nucleotide sequence ID" value="XM_035438746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GMV8"/>
    <dbReference type="GeneID" id="100761203"/>
    <dbReference type="KEGG" id="cge:100761203"/>
    <dbReference type="CTD" id="84735"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000008">
        <property type="entry name" value="Cytosolic non-specific dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF1">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="229"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035294637.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55498" checksum="B6F0AB7B7F36F60D" modified="2023-06-28" version="1">LLLLLLEQRMLSSSSPPSGLLEKVFQYIDLHQDEFVQSLKEWVAIESDSVQPMPHLRQELFRMMALAADKLRHLGARVDSVDLGSQQMPDGQCLPIPPIILAGLGNDPKKPTVCFYGHLDVQPAQKDDGWLTDPYTLTEVDGKLYGRGATDNKGPVLAWINAVGTFRALKQDLPVNVKFILEGMEEAGSVALEELVRREKDHFFSSVDYIVISDNLWISQKKPALTFGTRGNCYFMVEVKCREQDFHSGTFGGILNEPMADLVALLGSLVDSSGHILIPGIYDQMAPLTEEEKTMYRNIDLDMEEYQKSSQVEKFLFDTKEELLMHLWRYPSLSIHGIEGAFDEPGTKTVIPGRVIGKFSIRLVPHMNLSVVEKQVKQHLEAVFAKRNSFNKMTVSMVLGLQPWTANINDTQYLAAKRAIKTVFGVDPDMIQDGSTIPIAKLFQAITQKSVMMLPLGAVDDGEHSQNEKINRWNYIQGSKLFAAFFLELSKLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQX4</accession>
    <name>A0A9J7GQX4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Growth hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Somatotropin receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23 24 25 26" type="primary">Ghr</name>
    </gene>
    <organism evidence="21 25">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23 24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23 24">17A/GY</strain>
            <tissue evidence="22 23 24">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="17">On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type I cytokine receptor family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027257186.1">
        <property type="nucleotide sequence ID" value="XM_027401385.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027257187.1">
        <property type="nucleotide sequence ID" value="XM_027401386.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296477.1">
        <property type="nucleotide sequence ID" value="XM_035440586.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296478.1">
        <property type="nucleotide sequence ID" value="XM_035440587.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296479.1">
        <property type="nucleotide sequence ID" value="XM_035440588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GQX4"/>
    <dbReference type="GeneID" id="100763540"/>
    <dbReference type="KEGG" id="cge:100763540"/>
    <dbReference type="CTD" id="2690"/>
    <dbReference type="OrthoDB" id="9890215at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004903">
        <property type="term" value="F:growth hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060396">
        <property type="term" value="P:growth hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000269">
        <property type="entry name" value="Growth hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000318">
        <property type="entry name" value="Growth hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025871">
        <property type="entry name" value="GHBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015152">
        <property type="entry name" value="Growth/epo_recpt_lig-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003528">
        <property type="entry name" value="Long_hematopoietin_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF46">
        <property type="entry name" value="INTERLEUKIN 5 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09067">
        <property type="entry name" value="EpoR_lig-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12772">
        <property type="entry name" value="GHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01352">
        <property type="entry name" value="HEMATOPO_REC_L_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 22 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 19" id="KW-0732">Signal</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044698692" description="Growth hormone receptor" evidence="19">
        <location>
            <begin position="19"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="151"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027257186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027257187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035296477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035296478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_035296479.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="71626" checksum="3A635C1818B10189" modified="2023-06-28" version="1">MDLWRVFLTLALAISIDAFSGNGVKPATLGRVPPILQRINPSLGTSSSGKPQFTKCRSPELETFSCYWTEGDYHDLKIPGSIQLFYARRIAHEWNQEWKECPDYVSAGENSCYFNSSYTSIWIPYCIKLTTNGDLLDQKCFTVDEIVQPDPPIGLNWTLLNISLTGIHGDIQVRWQPPPSADIRKGWIILEYEVQFKEINETKWKVTGPLWSTSVPLYSLRLEKEYEVRVRSRQRNFEKFSDFSEVLYITFPQMSALTCEEDFQFPWFLIIIFGIFGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYKSDFYNDDSWVEFIELDIDDADEKTEGSDTDRLLSNAREKSLSILGAKDDDSGRTSCYDPDILDTDFHTSDMCDGTSEFAQPQKLKEEPDLLCLDQKNLKNSPYGASLGSLHPCIALTAEDKPQPLPSSEIESTHQPVSTQISSTASLANIDFYAQVSDITPAGSVVLSPGQKIKAGLAQCNTQPQPEVAAPCQENNSMNSAYFCESDAKKCIAVAPHLEATSCVKPSFNQEDIYITTESLTTARKSETTELAPDAEMPVPDYTTVHTVQSPRGLILNATALRLPDKKKFLSSCGYVSTDQLNKIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GTI9</accession>
    <name>A0A9J7GTI9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double C2-like domain-containing protein alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Doc2a</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035298098.1">
        <property type="nucleotide sequence ID" value="XM_035442207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GTI9"/>
    <dbReference type="GeneID" id="100773354"/>
    <dbReference type="KEGG" id="cge:100773354"/>
    <dbReference type="CTD" id="8448"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098850">
        <property type="term" value="C:extrinsic component of synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017158">
        <property type="term" value="P:regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04035">
        <property type="entry name" value="C2A_Rabphilin_Doc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08384">
        <property type="entry name" value="C2B_Rabphilin_Doc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000032">
        <property type="entry name" value="Double c2-like domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000023">
        <property type="entry name" value="Double C2-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014638">
        <property type="entry name" value="Doc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047022">
        <property type="entry name" value="Rabphilin_Doc2_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF1">
        <property type="entry name" value="DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036931">
        <property type="entry name" value="Doc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="253"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035298098.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="47427" checksum="BC9D51989C15AB43" modified="2023-06-28" version="1">MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRRGPGPEAAGGRGCGEAPAHLAPLALAPPAALLGATTPDDGAEVDSYDSDDTTALGTLEFDLLYDQASCTLHCRVLRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEELTYSGITDDDITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLPSPSSMSAALRGISCYLKELEQAEQGPGLLEERGRILLSLSYSSRRHGLLVGIVRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEMELSTLATKTLEVTVWDYDIGKSNDFIGEWRSPSGCCEGSGPGEWAMTGSACRGCSSGGVSLGPGARGEAQKHWSDCLHQPDTALERWHTLTSELPPAAGAFPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GVB8</accession>
    <name>A0A9J7GVB8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LOW QUALITY PROTEIN: GTPase ERas</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100769828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035299139.1">
        <property type="nucleotide sequence ID" value="XM_035443248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769828"/>
    <dbReference type="KEGG" id="cge:100769828"/>
    <dbReference type="OrthoDB" id="9835289at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035299139.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24585" checksum="703C4824D00E15BC" modified="2023-06-28" version="1">MALPTISSILDLSLKTQCTRSPEESHEACTQCKDTGRHLPEYKVVGASGFGKSALTIQTTXCFVKINDPTIQDCYWKEVALDNSGYILNVLYTAGXDILRALRDQCLAAGDGVLGFFALHDPSTLDQLQQIWSTCSPHQKQRLPLVLMGNKCDLVTAGDTHTAAAILANKWEVPFVKTSAKTRQGVEEAFALVVHEIQRAEEAVAEPSRNKTLQHKAVCSCGCSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GVF9</accession>
    <name>A0A9J7GVF9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-cell surface glycoprotein CD3 gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">T-cell receptor T3 gamma chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Cd3g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035299650.1">
        <property type="nucleotide sequence ID" value="XM_035443759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GVF9"/>
    <dbReference type="GeneID" id="100757196"/>
    <dbReference type="KEGG" id="cge:100757196"/>
    <dbReference type="CTD" id="917"/>
    <dbReference type="OrthoDB" id="8941324at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042105">
        <property type="term" value="C:alpha-beta T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045059">
        <property type="term" value="P:positive thymic T cell selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001337">
        <property type="entry name" value="T-cell surface glycoprotein CD3 gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015484">
        <property type="entry name" value="CD3_esu/gsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032052">
        <property type="entry name" value="Ig_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003110">
        <property type="entry name" value="Phos_immunorcpt_sig_ITAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10570:SF8">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10570">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN / DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16680">
        <property type="entry name" value="Ig_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02189">
        <property type="entry name" value="ITAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00077">
        <property type="entry name" value="ITAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51055">
        <property type="entry name" value="ITAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039896488" description="T-cell surface glycoprotein CD3 gamma chain" evidence="17">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin subtype 2" evidence="18">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035299650.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20475" checksum="94D079D183496772" modified="2023-06-28" version="1">MELEKGLTGLILVIFLLQGTVAQSKQESHLVKVDDNRGDGSVLLTCDLKDKTIMWLKDGNTISTPNATKNTWNLGSITKDPRGTFWCQGAKDKSKPLQVYYRMCENCIELNIGTISGFIFAEIISIFFLAVGVYFIAGQDGVRQSRASDKQTLLPNEQLYQPLKDRDNDQYSHLQGNQLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GX97</accession>
    <name>A0A9J7GX97_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cell adhesion molecule 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Cadm2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300239.1">
        <property type="nucleotide sequence ID" value="XM_035444348.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310118.1">
        <property type="nucleotide sequence ID" value="XM_035454227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GX97"/>
    <dbReference type="GeneID" id="100773220"/>
    <dbReference type="KEGG" id="cge:100773220"/>
    <dbReference type="CTD" id="253559"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05884">
        <property type="entry name" value="IgI_2_Necl-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07701">
        <property type="entry name" value="IgV_1_Necl-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000013">
        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000446">
        <property type="entry name" value="cell adhesion molecule 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF1">
        <property type="entry name" value="CELL ADHESION MOLECULE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="108"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035300239.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45293" checksum="4EEE7861D5FEA147" modified="2023-06-28" version="1">LGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQSLTLTCESKGKPLPEPVLWTKDGAELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPTTLLPTTIIPSLTTAPVTTTVAITTSPSTSASSSSRRDPNSLAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GYF4</accession>
    <name>A0A9J7GYF4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">IgG receptor FcRn large subunit p51</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">IgG Fc fragment receptor transporter alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Neonatal Fc receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26" type="primary">Fcgrt</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25 26">17A/GY</strain>
            <tissue evidence="25 26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer. Interacts with albumin/ALB; this interaction regulates ALB homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the MHC class I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276485.1">
        <property type="nucleotide sequence ID" value="XM_027420684.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302126.1">
        <property type="nucleotide sequence ID" value="XM_035446235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GYF4"/>
    <dbReference type="GeneID" id="100755637"/>
    <dbReference type="KEGG" id="cge:100755637"/>
    <dbReference type="CTD" id="2217"/>
    <dbReference type="OrthoDB" id="8890485at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030881">
        <property type="term" value="F:beta-2-microglobulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019864">
        <property type="term" value="F:IgG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000693">
        <property type="entry name" value="IgG receptor FcRn large subunit p51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000003">
        <property type="entry name" value="IgG receptor FcRn large subunit p51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF3">
        <property type="entry name" value="IGG RECEPTOR FCRN LARGE SUBUNIT P51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0390">IgG-binding protein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 25 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="235"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027276485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_035302126.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43207" checksum="73C10C39024E0E11" modified="2023-06-28" version="1">MRSPQGPCEESAGQGPEESRVPPASGCPVRMGMPQPWVLSLLLVLLPRTWGAETRPPLMYHLTAVSNPSKGSPSFWATGWLGPQQYLSYNSLRQEAQPCGAWMWENQVSWYWEKETVDLKSKQELFLKALGALETHIGQEGNFTLQGLLGCELAPNNSSLPTAVFALNGEDFMQFNPSIGNWSGEWPETEIVGDLWMKQPEAARKESEFLLTSCPERLLGHLERGLQYLEWKEPPSMRLKARPSNSGSSILTCAAFSFYPPELKLRFLRSGLAAGSGNSSIGPNGDGSFYASSLLEVKRGDEHHYQCQVEHKGLAQPLTVDLDVPARSSVPVIGIVLGFLVVIVAAAGGVLLWNRMRSGLPAPWLSLSGDDSGDLLPGGNLPPEADPHGANTFPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H0K9</accession>
    <name>A0A9J7H0K9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thyroid nuclear factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC113836212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300947.1">
        <property type="nucleotide sequence ID" value="XM_035445056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H0K9"/>
    <dbReference type="GeneID" id="113836212"/>
    <dbReference type="KEGG" id="cge:113836212"/>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000108">
        <property type="entry name" value="NK2 homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF33">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035300947.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="41755" checksum="E84622591A60FDB8" modified="2023-06-28" version="1">MWSGGGGKARGWEAAAGGRSSPSRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGTASLQGHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGAMSCSTLLYGRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H366</accession>
    <name>A0A9J7H366_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like V-type domain-containing protein FAM187A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Fam187a</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM187 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003504557.1">
        <property type="nucleotide sequence ID" value="XM_003504509.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303298.1">
        <property type="nucleotide sequence ID" value="XM_035447407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H366"/>
    <dbReference type="GeneID" id="100758476"/>
    <dbReference type="KEGG" id="cge:100758476"/>
    <dbReference type="CTD" id="100528020"/>
    <dbReference type="OMA" id="AWDKDST"/>
    <dbReference type="OrthoDB" id="9899560at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF7">
        <property type="entry name" value="IG-LIKE V-TYPE DOMAIN-CONTAINING PROTEIN FAM187A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039952174" evidence="8">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="268"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035303298.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48333" checksum="F62CEA0E0F38995B" modified="2023-06-28" version="1">MSLAHTTVLLWAWGSLQAFEIVEKENIFQKTPCPAFLMFDNAAYLADMSFELPCHCKPEDVSAVVWYYQKHLGSSHTTVLTDFDGRLLTEAAHVRAGSSMLVRFSIRMFSLLVFRAQPEDSGLYFCGTRKGDYFYAYDVDIQSSEGMVATFKDRGQEPLPDEYFGSLHVFTTFWEWTPCDRCGVHGEQWRLGLCYLQNPDLSPRYLKTLPDVVSCGSRAVPRKLWIRTRYHTPELLIQSCLVSCEKRNQIRKGMLTIYNYVSKMGSRPWLPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDRQPLYRTQYLKGVNRSMRVFIDHGNHLHIRFTQLSDRGIYYCWRQGLRIAGFRLGVTSRGRYPASLSDPETRSAVELTLIGYLLITAIFVTIHVCRCCCYSFRCCPNFSTHALLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4F7</accession>
    <name>A0A9J7H4F7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Solute carrier family 22 member 21 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100755213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303630.1">
        <property type="nucleotide sequence ID" value="XM_035447739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4F7"/>
    <dbReference type="GeneID" id="100755213"/>
    <dbReference type="KEGG" id="cge:100755213"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015651">
        <property type="term" value="F:quaternary ammonium group transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000070">
        <property type="entry name" value="Solute carrier family 22 member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004749">
        <property type="entry name" value="Orgcat_transp/SVOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00898">
        <property type="entry name" value="2A0119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="88"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035303630.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="61619" checksum="097AE49124AC3DD5" modified="2023-06-28" version="1">MPAYDEATAFLGEWGLFQRLIFFLLSASIIPNGFTGLSAVFLTASPEYRCLVPDTVNLSSAWRNHSIPLETKDGRQVPQKCRRYRLDTIANFSALGLEPGVDVDLEQLEQESCLDGWEYSKEIFLSTIVTEWDLVCQNDWKAPFTTSCFYVGVLLGSFISGQLSDRFGRKNVLFLTIGIHTGCSFLQVFSVSYEMFTALFTLVGLGHISNYVAAFVLGTEILSKSIRIIFATLGVCIFFAFGFMVLPLFAYFIRDWRMLQLAITMPGVLCAALWWFIPESPRWLVSQGRIKEAEVIIRRAAKTNGIVAPSTIFDDLELEDQNPKKAQSHHIFDLIRTGNIRILTIMSIILWLTISVGYFGLSLATPTLNGNIYLNCFLSAAVEVPAYVLAWLLLQHVTRRYSMAGSLFLGGSVLVLLPLVPSDYNFVSIGLVMLEKFGVTSAYSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYIVMGSLTVLIGIITLFFPESFGVALPNNLEKLQKVRGFRYGKKSTASVDREDPKVLITAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4M0</accession>
    <name>A0A9J7H4M0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Scavenger receptor cysteine-rich type 1 protein M130</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Cd163</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with CSNK2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304642.1">
        <property type="nucleotide sequence ID" value="XM_035448751.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314127.1">
        <property type="nucleotide sequence ID" value="XM_035458236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4M0"/>
    <dbReference type="GeneID" id="100768770"/>
    <dbReference type="KEGG" id="cge:100768770"/>
    <dbReference type="CTD" id="9332"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CD163 molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="SRCR"/>
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    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF484">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0011">Acute phase</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="18">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
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    <feature type="domain" description="SRCR" evidence="18">
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            <begin position="132"/>
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    <feature type="domain" description="SRCR" evidence="18">
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            <begin position="240"/>
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    <feature type="domain" description="SRCR" evidence="18">
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            <begin position="347"/>
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    <feature type="domain" description="SRCR" evidence="18">
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            <begin position="452"/>
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    </feature>
    <feature type="domain" description="SRCR" evidence="18">
        <location>
            <begin position="557"/>
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        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="18">
        <location>
            <begin position="694"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="18">
        <location>
            <begin position="799"/>
            <end position="901"/>
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    </feature>
    <feature type="domain" description="SRCR" evidence="18">
        <location>
            <begin position="904"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="63"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="94"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="158"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="171"/>
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="202"/>
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        </location>
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    <feature type="disulfide bond" evidence="16">
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            <begin position="265"/>
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="278"/>
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        </location>
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    <feature type="disulfide bond" evidence="16">
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            <begin position="309"/>
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    <feature type="disulfide bond" evidence="16">
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            <begin position="372"/>
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    <feature type="disulfide bond" evidence="16">
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            <begin position="385"/>
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        </location>
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="477"/>
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        </location>
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="490"/>
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        </location>
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="521"/>
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            <begin position="582"/>
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    <feature type="disulfide bond" evidence="16">
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            <begin position="595"/>
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    <feature type="disulfide bond" evidence="16">
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        </location>
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    <feature type="disulfide bond" evidence="16">
        <location>
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        </location>
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    <feature type="disulfide bond" evidence="16">
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        </location>
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        <location>
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        </location>
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="870"/>
            <end position="880"/>
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    <feature type="disulfide bond" evidence="16">
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="973"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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    <evidence type="ECO:0000256" key="10">
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064784"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035304642.1"/>
        </source>
    </evidence>
    <sequence length="1111" mass="119768" checksum="9C0C045C69018028" modified="2023-06-28" version="1">MAVVSVSLLSVSAVTNSSGGLKKELRLAGGENNCSGRVEVKIHEKWGTVCQNNWSMNEVSVVCRQLGCPTSIQALGWPNSSAGSGDIWMDKVSCTGNESALWDCKHEGWGKHNCTHEQDVGVTCSDGSNLEMKLVNDRPNRCLGRVEVKFQGKWGTVCDDNFSKDHATVICKQLGCGSAISFSGSAKFGAGSGPIWLDDLVCDGNESALWDCKHGAWGKHNCDHAEDVGVICLEGADLSLRLADGGSKCSGRLEVRFQDEWGTVCDDSWDALDASVVCKQLGCPAAISLIGRVNTSEGSGQIWLDNVSCKGDEAALWDCKHQEWGKHYCNHREDAGVTCSDGSDLELRLVGGGSRCSGTVEVEIQKLKGNICSRGWTLVDADVVCRQLGCGSALQTSSKIYSKSMATDTWLFPGSCSGNETSLWQCRNWQWGGLSCDHFEEAQVTCSGHREPRLVGGEIPCSGRVEVKHGDVWGSVCDFGLSLEAASVVCRELQCGTVISILGGAHFGEGSGQIWTEEFQCTGNESHLSLCSVAPPLEESCSHSRDVSIVCSRYTEIRLAGGKSSCEGRVEIKVLGAWGPLCNSHWDIEDAHVLCQQLKCGVALSTPGGAHFGKGAGQVWRHMFHCTGTEQHMGDCLVTALGAPVCSEGQVASVICSGNQSQILQPCSSSSSVQTTSSTIPNQSDVPCIASGQVRLVDGGSRCAGRVEVYHEGVWGTICDDSWDLIDASVVCKQLDCGVAINATGSAYFKEGTGNIWLDEINCSGKESQIWQCRSHGWGRHNCRHKEDAGVICSEFMSLRLTNDVPRENCTGHLEVFYNGTWGSVGSSNMSSTTVGVVCRQLGCADSGTLKPTSADKTPSRLMWIDNVQCPKGVDTLWQCPSSPWKQRQASPSEESWIVCDNKVRLQGGHTDCSGRVEIWHKGSWGTVCDDSWDLNDAKVACRQLGCGQAVKALKEAAYGPGTGPIWLNEMRCRGKETSLWDCPAKPWSHSDCGHKEDASIQCLPGAPPKSEQGHSVLVALLICGAILLVLVIAFLLWTLKRRQIQRLTVSSRGEISIHQVQYQEMNSRADDLDLLKSSENSNDFNADGLTSLSKYLPIPGFKKGSNSEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H545</accession>
    <name>A0A9J7H545_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Glycogen synthase kinase-3 alpha isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Gsk3a</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12801"/>
            <dbReference type="Rhea" id="RHEA-COMP:13701"/>
            <dbReference type="Rhea" id="RHEA-COMP:13702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53904"/>
            <dbReference type="Rhea" id="RHEA-COMP:13703"/>
            <dbReference type="Rhea" id="RHEA-COMP:13704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305189.1">
        <property type="nucleotide sequence ID" value="XM_035449298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H545"/>
    <dbReference type="GeneID" id="100757049"/>
    <dbReference type="CTD" id="2931"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:insulin receptor signaling pathway"/>
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        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:negative regulation of TOR signaling"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
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        <property type="term" value="P:regulation of neuron projection development"/>
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        <property type="term" value="P:Wnt signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="GSK-3"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="STKc_GSK3"/>
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        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
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    </dbReference>
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        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="179"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="507"/>
            <end position="543"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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            <dbReference type="ARBA" id="ARBA00047899"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048291"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048878"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035305189.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="57572" checksum="6425D95995016CA4" modified="2023-06-28" version="1">MSGGGPSGGGPGSSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGSGGGKASVGAMGGGVGASGSGGGPSGSGGGGSAGAGAGTSFPPPGVKLGHRKKQLEVHRAVSHRDLGSRGSRIKELGGSHPLEFRIRITSIREAEVTGPILPVSSIKVPGDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPAGPTTLTSSSQALTETQSGPDWQAPDATPTLANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H8M1</accession>
    <name>A0A9J7H8M1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Leucine-rich repeat-containing G-protein coupled receptor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Lgr5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035307252.1">
        <property type="nucleotide sequence ID" value="XM_035451361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H8M1"/>
    <dbReference type="GeneID" id="100763381"/>
    <dbReference type="KEGG" id="cge:100763381"/>
    <dbReference type="CTD" id="8549"/>
    <dbReference type="OrthoDB" id="1883493at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15363">
        <property type="entry name" value="7tmA_LGR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000028">
        <property type="entry name" value="leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000028">
        <property type="entry name" value="leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF71">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="549"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035307252.1"/>
        </source>
    </evidence>
    <sequence length="882" mass="97030" checksum="FEFE60753B248F44" modified="2023-06-28" version="1">MQSSAFQASAQRMHSCNPTGNTFEPQSLTAAAPAPRPSPLHRHVPWDLSMNNISQLPPSLLHSLRFLEELRLAGNALTHIPKGAFTGLHSLKVLMLQNNQLRQVPSEALQNLQSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEVPVQAFRSLSALQAMTLALNKIHHIPDLAFGNLSSLVVLHLHNNRVHSLGKKCFEGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPEKAFVGNPSLVTIHFYDNPIQFVGISAFQHLPELRTLTLNGASQITEFPDLTGTGNLESLTLTGAKISSLPQAVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKAGTFQQLFNLRSLNLAWNKIAIIHPDAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHLKLTGNRALQSLIPSSNFPELKIIEMPYAYQCCAFGVCENIYKISTPWNKGDNSSVDDLHKKDTGLLQVQDERDLEDFLLDFEEDLKSLHSVQCSPSPGPFKPCDHLFGSWLIRIGVWAIAVLALSCNALVTSTVFRTTLYISSIKLLIGVIAVVNMLMGVSSAMLAVVDTFTFGSFAQHGAWWEDGVGCQVVGFLSIFASESSVFLLTLAALERGFSVKCSSKFETKTPLSSLKVIILLCVLLALTIATVPLLGGSEFNASPLCLPLPFGEPSTTGYMVALVLLNSLCFLIMTIAYTKLYCNLEKGDLENLWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFISPEVIKFILLVIVPLPACLNPLLYIVFNPHFKEDMGSLGKQTCFWTRSKHPSLLSINSDDVEKRSCDSTQALVAFTHASIAYDLPSNSGSSSAYPMTESCHLSSEVFVPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HAT9</accession>
    <name>A0A9J7HAT9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Uncharacterized protein C2orf15 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">CUNH2orf15</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2 3 4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2 3 4">17A/GY</strain>
            <tissue evidence="2 3 4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_016835367.2">
        <property type="nucleotide sequence ID" value="XM_016979878.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242510.2">
        <property type="nucleotide sequence ID" value="XM_027386709.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308629.1">
        <property type="nucleotide sequence ID" value="XM_035452738.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308630.1">
        <property type="nucleotide sequence ID" value="XM_035452739.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317341.1">
        <property type="nucleotide sequence ID" value="XM_035461450.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317342.1">
        <property type="nucleotide sequence ID" value="XM_035461451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HAT9"/>
    <dbReference type="GeneID" id="107978150"/>
    <dbReference type="KEGG" id="cge:107978150"/>
    <dbReference type="CTD" id="118967652"/>
    <dbReference type="OrthoDB" id="9441888at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041537">
        <property type="entry name" value="DUF5547"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17701">
        <property type="entry name" value="DUF5547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_027242510.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035308629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035308630.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9577" checksum="0BB9554BEBF735FD" modified="2023-06-28" version="1">MGFFLSKASTQTTAVLVDSEVNDHLMQRAEKSELEPVTRLFQTTNKIKLEDTSQGNFTRKEGTDTGWNSMSFVKENDGLVMTDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HB11</accession>
    <name>A0A9J7HB11_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein transport protein Sec61 subunit gamma isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Sec61g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035308763.1">
        <property type="nucleotide sequence ID" value="XM_035452872.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311700.1">
        <property type="nucleotide sequence ID" value="XM_035455809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HB11"/>
    <dbReference type="GeneID" id="100772250"/>
    <dbReference type="CTD" id="23480"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035308763.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14046" checksum="A42795B826A419E4" modified="2023-06-28" version="1">MSGPGNDGNEGWGEGATVLTGCRDEGEGAIDEPGGHELRPGSCRIRTSPLGWIADGQVDRDQIQAQDLPVWPQVEVSSQTCLEELSTMDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKGLGTNSVIKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCY8</accession>
    <name>A0A9J7HCY8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">LOW QUALITY PROTEIN: insulin-like growth factor 2 mRNA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC118239813</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRM IMP/VICKZ family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035309717.1">
        <property type="nucleotide sequence ID" value="XM_035453826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="118239813"/>
    <dbReference type="KEGG" id="cge:118239813"/>
    <dbReference type="OrthoDB" id="752362at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.210:FF:000001">
        <property type="entry name" value="insulin-like growth factor 2 mRNA-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000026">
        <property type="entry name" value="Insulin-like growth factor 2 mRNA-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000027">
        <property type="entry name" value="insulin-like growth factor 2 mRNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000099">
        <property type="entry name" value="insulin-like growth factor 2 mRNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035309717.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57150" checksum="A3DE1729FCBAFD79" modified="2023-06-28" version="1">MRESRATRKIEHSVPKKQMSRKIQIRNIPPQLRWEVLDSLLAQYGTVENCEQVNTESETAVVNVTYSNREQTRQAIMKLNGHQLENHALKVSYISDEQLAQGPENGRRGGFGSRGQPRQESPVAAEAPAKQQQVDIPLRLLVPTQNVGAIIGKEGATIRNITKQTQSKIKVHRKENAGAAEKAISVHSTPEGCSSACKMILEIMHKEAKDTKTAHEVPLKILAHNSFVGRLIGKEGRNLKXVEQDTETKITISSLQHLTLYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLIPGLNLASVGLFPASSSAVPLPPSSVTGAAPYCSFKQATEQEMVQVFIPAQAVGAIIGKKGQHIKQLSWFTSASIRIAPPETPDSKVRMVIITGPPEAQFKAQGRIYDKIKEENFFGPKEEVKLETHIRVPASAAGRVIGKGGKKVNELQKLTAAEVLVPRDQIPDENDQVIVKIIGHFYASQMAQRKIRDILAHVKQQHQKGQSNQAQARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JAN2</accession>
    <name>A0A9J7JAN2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho guanine nucleotide exchange factor 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Guanine nucleotide exchange factor GEFT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Rac/Cdc42/Rho exchange factor GEFT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">p63RhoGEF</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Arhgef25</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007646293.1">
        <property type="nucleotide sequence ID" value="XM_007648103.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248040.1">
        <property type="nucleotide sequence ID" value="XM_027392239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JAN2"/>
    <dbReference type="GeneID" id="100758200"/>
    <dbReference type="KEGG" id="cge:100758200"/>
    <dbReference type="CTD" id="115557"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13241">
        <property type="entry name" value="PH2_Kalirin_Trio_p63RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000184">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000008">
        <property type="entry name" value="rho guanine nucleotide exchange factor 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF117">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="15">
        <location>
            <begin position="197"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="385"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="520"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027248040.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="68044" checksum="B806143946EB03CA" modified="2023-06-28" version="1">MSTGLGARCLPSFHSRVPFAKMSILATSSEGWQRREPWKTGSAHRGGGRLGVPLGLGVWSWDSVHQLLFFFSLESYSIAGSEGSVSASAASGLGAPSGLSSHSCSPAPPGPVTGLRRWLDHSQHCLSVETEADSGQTGQYENWMLEPTLATGDGLPELTLLTTLLEGPGDKTQPPEEETLSQGPQNEEEQKKVALERSLFVLNELVETEKMYVDDLGQIVEGYMATMATQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQLCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYSRAGMDTEELEQAVEVMCFVPKRCDDMMSLGRLRGFEGKLTAQGKLLGQDTFLVTEPEAGGLLSSRGRERRVFLFEQIVIFSEALGGGGRGGTQPAYVYKNSIKVSCLGLEGNLQGNPCRFALTSRGPEGGIQRYILQASDPAISQAWIKQVAQILESQRDFLNALQSPIEYQRRESQTNSLGRAGGPGVGSPGRMRPGDLTQVSMHTPTNGSLPSLLLLPKGEVPRAPLPLDIQALSDIPQTPHNPPALPALSTPPCQARLAKLDEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JBL4</accession>
    <name>A0A9J7JBL4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Partitioning defective 3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Atypical PKC isotype-specific-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">Pard3</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
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    <reference evidence="26" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <strain evidence="27">17A/GY</strain>
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        </source>
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        <text evidence="21">Interacts with PRKCZ.</text>
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            <location evidence="3">Tight junction</location>
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        <subcellularLocation>
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            <location evidence="5">Cell cortex</location>
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        <subcellularLocation>
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            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Par3_HAL_N_term"/>
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    </dbReference>
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    <keyword evidence="20" id="KW-0131">Cell cycle</keyword>
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    <keyword evidence="19" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
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    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JCL3</accession>
    <name>A0A9J7JCL3_CRIGR</name>
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        <submittedName>
            <fullName evidence="8">Keratinocyte-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC118237674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027256143.1">
        <property type="nucleotide sequence ID" value="XM_027400342.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="118237674"/>
    <dbReference type="KEGG" id="cge:118237674"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020977">
        <property type="entry name" value="Beta-casein-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12304">
        <property type="entry name" value="BCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027256143.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="21680" checksum="5079E1BE36B60160" modified="2023-06-28" version="1">MRVGLALILVGHVNLLVGAVLHGTVLRHMANPRGAVTPEYTTANVISVGSGLLSVSVGLVALLAFRNLLRPRLHWALGTLALVNLLLSAACSMGLLLAVSLTIANGGRRLIADCHPGLLDPSIPLDQGPGHTDCSFDPTRIYDTALALWIPSFFMSAAEATLSGYCCVAALTLRGIGPCRKEGLQGQLEELTELEPPKCKRQENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JFQ0</accession>
    <name>A0A9J7JFQ0_CRIGR</name>
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        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100765363</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027267425.1">
        <property type="nucleotide sequence ID" value="XM_027411624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JFQ0"/>
    <dbReference type="GeneID" id="100765363"/>
    <dbReference type="KEGG" id="cge:100765363"/>
    <dbReference type="OrthoDB" id="9592300at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15234">
        <property type="entry name" value="7tmA_OR7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000009">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="67"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027267425.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37812" checksum="79F89768DBF48C66" modified="2023-06-28" version="1">MAHYCIKTTNPDKSLRSTQTMNINIASEPGNQTGIFHFFLMELTHDGTMEPLIFGLFLFTYLVTILGNLLIILAVISDSHLQTPMYLFLSKLSFTDICLSTTTVPNMLKNIHTHDQSISYAGCLTQACFVLNFAVLESCILAVMGYDRYAAICHPLNYKRIMNPNFCCLLILLSLIISIVNSLLQCLMVLRLSFCTNFQLPLFFCELAQVMKLACSDALINYILIYLATFIFGGIPISGIIFSYTRIVSSILRISSLKGRYKAFSTCGSHFVVVSIFYGAGVGVYISSAITVSPQITTVSYMMYTVLPQMLNPFIYSLRNRDMKKALGKLITKISCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JHQ7</accession>
    <name>A0A9J7JHQ7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major vault protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Mvp</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007648955.2">
        <property type="nucleotide sequence ID" value="XM_007650765.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260387.1">
        <property type="nucleotide sequence ID" value="XM_027404586.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JHQ7"/>
    <dbReference type="GeneID" id="100751094"/>
    <dbReference type="KEGG" id="cge:100751094"/>
    <dbReference type="CTD" id="9961"/>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000002">
        <property type="entry name" value="Major vault protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.620:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF3">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="15">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="12">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="12">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="12">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="12">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="15">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="12">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="12">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="17">
        <location>
            <begin position="379"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="12">
        <location>
            <begin position="384"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="16">
        <location>
            <begin position="457"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="14">
        <location>
            <begin position="519"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027260387.1"/>
        </source>
    </evidence>
    <sequence length="902" mass="100479" checksum="9FDFF260950922CA" modified="2023-06-28" version="1">MATEEAIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPVRMVTVPPRHYCIVANPVSRDAQSLVLFDTTGQVRLRHADQEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFKDENGDTIMAGDEWLFEGPGTYIPQKEVEVVEIIQATVIRQNQALRLRARKECFDRDGKQRVTGEEWLVRSVGAYLPAVFEEVLDLVDAVILTEKTALHLRARQNFKDLRGVAHRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPRHYCVILDPMGPDGKNQLGQKRVVKGEKSFFLQPGERLERGIQDVYVLSEQQGLLLRALQPLEEGEGQEKVSHQAGDRWLIRGPLEYVPSAKVEVVEERQAIPLDQNEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNLGHDPLADRGQKATAKTLQPSAPRNKTRVVSYRVPHNAAVQVYDYRAKRARVVFGPELVSLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPEETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRMAVFGFETSADTGPDGTLLPRARDRATFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAEALAIETEAELERVKKVRELELVYARAQLQLEVSKAQQLADVEAKKFKEMTEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFNTALGCWGWGLMVSHRHKSKVAGPARGRLAFASPPSSSLFEAATLCLRSTLTALMMDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JIG6</accession>
    <name>A0A9J7JIG6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Terminal nucleotidyltransferase 4B</fullName>
            <ecNumber evidence="6">2.7.7.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Non-canonical poly(A) RNA polymerase PAPD5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">PAP-associated domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Terminal guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Terminal uridylyltransferase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Topoisomerase-related function protein 4-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">Tent4b</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
            <tissue evidence="35">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="6"/>
    <dbReference type="RefSeq" id="XP_027261325.1">
        <property type="nucleotide sequence ID" value="XM_027405524.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100759123"/>
    <dbReference type="KEGG" id="cge:100759123"/>
    <dbReference type="CTD" id="64282"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070568">
        <property type="term" value="F:guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060212">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905870">
        <property type="term" value="P:positive regulation of 3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000015">
        <property type="entry name" value="Terminal nucleotidyltransferase 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF51">
        <property type="entry name" value="TERMINAL NUCLEOTIDYLTRANSFERASE 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="23" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="33">
        <location>
            <begin position="206"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="32">
        <location>
            <begin position="394"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="521"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="31">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="608"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00076411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00076530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00079354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00081892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00082009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="RefSeq" id="XP_027261325.1"/>
        </source>
    </evidence>
    <sequence length="658" mass="71890" checksum="D80C380AAFC334F3" modified="2023-06-28" version="1">MDPRIAWFQPEQLGPSNSLWMQIWETTQGLRNLYFNHHCHSSGASSASGGTASGGSGSGPGSPGGXGPAPVGMFRSGERPLGGLAVPAEQRDFLPLETTNNNNNHHQPAAWARRAAAGPSASPVPSAPSSPRPAAALPTSETGDPASGSSNKRKRDNKASTYGLNYSLLQPSGGHAAGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVSRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLQNRSEPSCNGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPPAGNRVGSQDVSLEVSQAVGKVQSTQTTNTPNSTNKSQHGSARLFRSSSKGFQGTAQTSHGSLMTSKQHQGKSNTQYYHGKKRKHKRDAPLSDLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JK53</accession>
    <name>A0A9J7JK53_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidylcholine:ceramide cholinephosphotransferase 1</fullName>
            <ecNumber evidence="13">2.7.8.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Protein Mob</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sphingomyelin synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Transmembrane protein 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 27 28 29 30 31 32 33 34 35 36 37" type="primary">Sgms1</name>
    </gene>
    <organism evidence="25 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26 27 28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26 27 28">17A/GY</strain>
            <tissue evidence="26 27 28">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:43320"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:78421"/>
            <dbReference type="ChEBI" id="CHEBI:82983"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:43321"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:43322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:42140"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:65107"/>
            <dbReference type="ChEBI" id="CHEBI:78650"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:42141"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:42142"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:41796"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:67042"/>
            <dbReference type="ChEBI" id="CHEBI:78647"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41797"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:41798"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:18765"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="EC" id="2.7.8.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:18766"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:18767"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:36079"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:73203"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:36080"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.27" evidence="13"/>
    <dbReference type="RefSeq" id="XP_027262201.1">
        <property type="nucleotide sequence ID" value="XM_027406400.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262202.1">
        <property type="nucleotide sequence ID" value="XM_027406401.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262203.1">
        <property type="nucleotide sequence ID" value="XM_027406402.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262204.1">
        <property type="nucleotide sequence ID" value="XM_027406403.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262205.1">
        <property type="nucleotide sequence ID" value="XM_027406404.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262206.1">
        <property type="nucleotide sequence ID" value="XM_027406405.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262207.1">
        <property type="nucleotide sequence ID" value="XM_027406406.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262208.1">
        <property type="nucleotide sequence ID" value="XM_027406407.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297778.1">
        <property type="nucleotide sequence ID" value="XM_035441887.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297780.1">
        <property type="nucleotide sequence ID" value="XM_035441889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297781.1">
        <property type="nucleotide sequence ID" value="XM_035441890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297782.1">
        <property type="nucleotide sequence ID" value="XM_035441891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JK53"/>
    <dbReference type="GeneID" id="100766719"/>
    <dbReference type="KEGG" id="cge:100766719"/>
    <dbReference type="CTD" id="259230"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sphingomyelin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09514">
        <property type="entry name" value="SAM_SGMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000040">
        <property type="entry name" value="Phosphatidylcholine:ceramide cholinephosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF28">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="24">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027262201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_027262202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027262203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027262204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027262205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027262206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_027262207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_027262208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="RefSeq" id="XP_035297778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="RefSeq" id="XP_035297780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_035297781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="XP_035297782.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="48589" checksum="ACE755E555549F33" modified="2023-06-28" version="1">MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGRDLINLTQEDFTKPPLCRVSSDNGQRLLDMIETLKMEHHMEAHKNGHANGHLSVGVDIPNPDGGSFSIKMKPNGMPNGYRKEMIKIPMPEPERSQYPMEWGKTLLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQVRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLGRQVKYSRLVNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JL81</accession>
    <name>A0A9J7JL81_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rho GTPase-activating protein 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Neuron-associated developmentally-regulated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Rho-type GTPase-activating protein 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Arhgap17</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with NHERF1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027266095.1">
        <property type="nucleotide sequence ID" value="XM_027410294.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JL81"/>
    <dbReference type="GeneID" id="100759183"/>
    <dbReference type="KEGG" id="cge:100759183"/>
    <dbReference type="CTD" id="55114"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07618">
        <property type="entry name" value="BAR_Rich1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04386">
        <property type="entry name" value="RhoGAP_nadrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000019">
        <property type="entry name" value="rho GTPase-activating protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="14"/>
            <end position="246"/>
        </location>
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            <begin position="291"/>
            <end position="481"/>
        </location>
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        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
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        <location>
            <begin position="555"/>
            <end position="834"/>
        </location>
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            <begin position="498"/>
            <end position="514"/>
        </location>
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            <begin position="583"/>
            <end position="614"/>
        </location>
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            <begin position="631"/>
            <end position="656"/>
        </location>
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            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
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            <begin position="692"/>
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        </location>
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        <source>
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            <dbReference type="ARBA" id="ARBA00083392"/>
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            <dbReference type="PROSITE" id="PS50238"/>
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            <dbReference type="PROSITE" id="PS51021"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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        <source>
            <dbReference type="RefSeq" id="XP_027266095.1"/>
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    </evidence>
    <sequence length="881" mass="95332" checksum="3D9EE26EF2F3A148" modified="2023-06-28" version="1">MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHHSHKRLIACFQGQHGTDVERRHKKLPLTALAQNMQEASAQLEESLLGKMLETCGDAENQLALELSQYEALVEKEIVDPLYGIAEVEIPNIQKQRKQLAKLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEMRAHQGLSIAYFPLWKPPTCSQSDCSQTLHPGPQTCSTQQPNNCDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFSLYEEWTQVASVQDQDKKLQYLWTTCQKLPPQNFVNFRYLIKFLAKLAQTSDINKMTPSNIAIVLGPNLLWAKQEGTLAEIAAATSVHVVAVIEPIIQHADWFFPGEIEFNVSEAFVPLATPNSNHTSHTGNDSDSGTLERKRPVSMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGNALAPAGPELPSQSSRADSSSGGGPIPSSAGILEQGLSPGDSSPPKPKDSVCAAVPAPGRNNNQVTTGPSQAPSGGSSHQLSVGTPHSAAGPSPHTLRRAVKKPAPAPPKPGNLPPGHPGGQSSPGTGTGTSPKPNTRSPSPPPQQAPGTRRSSSSLPPIQAPSHPPPQPPTQPRLGEQGPEPGPTPPQTPTPPSTPPLAKQNPSQSENTQQHGTLPRPRPVPKPRNRPSVPPPPHPPGAHAGDNSLAPAAPTASRIVTDALPSALTDTNSRVSESLRNIFPEMHSDLASKEVPGHILLDIDNDTESTAL</sequence>
</entry>
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    <accession>A0A9J7JNA1</accession>
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        <name evidence="7" type="primary">Cib4</name>
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        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetulus</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="75"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_027280321.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18091" checksum="C1E4713CDA141FA8" modified="2023-06-28" version="1">MPPLLVNPFRDRICRVFSHNNVFSFEDVLGMASVFSEQACPSLKIEYAFRIYDFNENGFIDEDDLQKIVLRLLNSDDVSEDLLMDVTHHVLSESDLDNDNMLSFSEFEHAMAKSPDFMNRDSFFQFISDSFLGMLIWRQPCDPAALRETPAPWHGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JS80</accession>
    <name>A0A9J7JS80_CRIGR</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein CXorf49 homolog</fullName>
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        <name evidence="4" type="primary">LOC113837511</name>
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    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027287564.1">
        <property type="nucleotide sequence ID" value="XM_027431763.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JS80"/>
    <dbReference type="GeneID" id="113837511"/>
    <dbReference type="KEGG" id="cge:113837511"/>
    <dbReference type="OrthoDB" id="9629060at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027822">
        <property type="entry name" value="DUF4641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31866">
        <property type="entry name" value="GENE 4779-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31866:SF2">
        <property type="entry name" value="RIKEN CDNA 8030474K03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15483">
        <property type="entry name" value="DUF4641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027287564.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="57336" checksum="3D7FB8C54AEFCD34" modified="2023-06-28" version="1">MSSPDEVSAPEVSGDKDVPSTGDMNSQDMASAPEADLGQEGREHLGDTLINPRVPEGESLVQRPLEIREGEGGLPRIESCELKSGPKFEAREVEEGVLTDPAGPTSSPVGQEEGGEVSGYFLPQLSIEAMTIMRELTDLQARKFCRYPSPQSCAAELTALWSSIGEGSNRGAEPVSSGEGKQVSTGSLYPRGLGRSRAWVTSRRGTTSKMVRSEAVQRSTSKPASDESSDSQTMKVTICLKEGNQAKSSGRTELEDSGKHTNVQGRGRFVHVPPSVLSSATRRFSAGLEKPVSGEPEGSLCKKRQSMVWGKEGSRPGYPGASAASVSTAAANSAAAPAPVASGALPKTNTRKKTAQEKKSLSDASRGPLGRTFPPWGQRLKSAPVEPATLPPISGVALIGKTSKNSLPSGPKDCKPFCTGKRSMARKTKESQPGAKEDDDQSRDPGLQAQLPTHRAEQPSTCTNRREMTSGDANFRAPQVPGHSQLLTLSQRSSRSRALAPAGRESTGDWCLMLQKEIEELKEQLAIMQALNEKFQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JUV1</accession>
    <name>A0A9J7JUV1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100769971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276801.1">
        <property type="nucleotide sequence ID" value="XM_027421000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JUV1"/>
    <dbReference type="GeneID" id="100769971"/>
    <dbReference type="KEGG" id="cge:100769971"/>
    <dbReference type="OrthoDB" id="6147321at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15226">
        <property type="entry name" value="7tmA_OR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000012">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276801.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34879" checksum="6E17FA541E234D07" modified="2023-06-28" version="1">MDGNNHSVVSEFVFLGLSNTWGIQLLLFLFSSVFYTASLMGNLLIVFSVTADSNLHSPMYFLLANLSFLDLGCGSVTAPKMIYDLFRKHKSISFGGCITQVFFIHTFGGTEMVLLTAMAFDRYVAICKPLHYLTIMRPGMCILILSVAWILGLIHSVAQLAFVVDLPFCGPNILDSFYCDLPQLIKLACTETNKLEFMVTANSGLMSVGSFFILIISYIFILVTVRKHSSGGISKALSTLSAHVTVVVLFFGPLIFFYTWPFPSSHWDKFLAIFDAVVTPFLNPVIYTFRNKEMKAAMKKLCYQIVSYRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JWP9</accession>
    <name>A0A9J7JWP9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L36a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC103163079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027281879.1">
        <property type="nucleotide sequence ID" value="XM_027426078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JWP9"/>
    <dbReference type="GeneID" id="103163079"/>
    <dbReference type="KEGG" id="cge:103163079"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027281879.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12373" checksum="4DDB415DEAA7ABEB" modified="2023-06-28" version="1">MVNMPKTGRTFCKKCGKHQPHKVTQDKKGKYSLYAQGKWHYDWKQSGYGGQTKPIFRKKAKTTKKIVLRLECGEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JYM0</accession>
    <name>A0A9J7JYM0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vitronectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">S-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Serum-spreading factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Vtn</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
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        <text evidence="11">Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.</text>
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        <subcellularLocation>
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            <location evidence="1">Extracellular space</location>
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        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:integrin binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:polysaccharide binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="vitronectin"/>
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        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMB_2"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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    <feature type="chain" id="PRO_5039928785" description="Vitronectin" evidence="17">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="18">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
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            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
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            <end position="251"/>
        </location>
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    <feature type="repeat" description="Hemopexin" evidence="15">
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            <end position="478"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
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            <end position="111"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
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        </location>
    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K1P0</accession>
    <name>A0A9J7K1P0_CRIGR</name>
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        <name type="common">Chinese hamster</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
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            <taxon>Cricetulus</taxon>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
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    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with HNRNPK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM42 family.</text>
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        <property type="component" value="Chromosome 9"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA-binding protein 42 isoform X2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="375"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027287042.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="49851" checksum="58B5DF355A206A7C" modified="2023-06-28" version="1">MAGAGPAPGLPVAGGPVVPGPGVGLPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPAAVPAVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPADRSHLDSPEAREAMFLRRAAVAPQRAPILRPAFVPHVLQRADSALSSAAGGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPAAPRELGLGLGLGLKEKEEAAVAAAAGLEDASAAVAVGAGGAPTGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K2P9</accession>
    <name>A0A9J7K2P9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal Pro-X carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Proline carboxypeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Prolylcarboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC100753648</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.</text>
            <dbReference type="EC" id="3.4.16.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.2" evidence="14"/>
    <dbReference type="RefSeq" id="XP_035297246.1">
        <property type="nucleotide sequence ID" value="XM_035441355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314702.1">
        <property type="nucleotide sequence ID" value="XM_035458811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K2P9"/>
    <dbReference type="GeneID" id="100753648"/>
    <dbReference type="KEGG" id="cge:100753648"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060055">
        <property type="term" value="P:angiogenesis involved in wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043535">
        <property type="term" value="P:regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000002">
        <property type="entry name" value="lysosomal Pro-X carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035297246.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44239" checksum="7BA8FBE07B5FE757" modified="2023-06-28" version="1">MWDVAEKLKALLVFAEHRYYGESLPFGAESFKDSKHLNFLTSEQALADFAELIRHLRRTVPGADSQPVIAIGGSYGGVLAAWFRMKYPHLVIGALAASAPIWQFEELIPCGMFMKIVTEDFRKSGKKCSESILRSWGAINRLSNTGSGLPWLTKAFHLCSSLNSEDVQRLKDWISETWVNLAMVNYPYPANFLKPLPSWPLKVVCQYLTNPFMSDSLLVQNIYQALNVYYNYSGQSRCNNISETTIGSLGSRVWGYQTCTEIILPFCTNGVDDMFEARAWDLDKYSDDCYKQWGVRPRPSWITTLYGGKDIRSHSNIIFSNGDLDPWSGGGVTEDLSDTLVAVNIPEGAHHLDLRSSTETDPPSLQLARSVEVRHMKQWISDFYGNYRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K3M5</accession>
    <name>A0A9J7K3M5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 6 superfamily member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Tm6sf1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May function as sterol isomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TM6SF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035298306.1">
        <property type="nucleotide sequence ID" value="XM_035442415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K3M5"/>
    <dbReference type="GeneID" id="100767990"/>
    <dbReference type="CTD" id="53346"/>
    <dbReference type="OrthoDB" id="8181520at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="CDD" id="cd21106">
        <property type="entry name" value="TM6SF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047195">
        <property type="entry name" value="TM6SF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059044">
        <property type="entry name" value="TM_Tm6sf1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568:SF10">
        <property type="entry name" value="TRANSMEMBRANE 6 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568">
        <property type="entry name" value="TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26083">
        <property type="entry name" value="TM_Tm6sf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="60"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="219"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035298306.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41957" checksum="EDFA2EBB37517B88" modified="2023-06-28" version="1">MSASAATGVFVLSLSAIPVTYIFNHLAAQHDSWTIVGVAALILLLVALLARVLVKRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSVHYLMYLVMVAAIAWDCCRESYRTIGLYWVGSIIMSIVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPPENYNYPSKVLQEAQAKALLRRPFDLILVVCLFLATGFCLFRGLIALDCPAELCRLYTQFQEPYLKDPAAYPKIQMLAYMFYSVPYFVIALYGLVVPGCSWMPDITLVHAGGIAQAQFSHIGASLHARTAYVYRVPEEAKILFLALNIAYGVLPQLLAYRCTYNPEFFIRIKADEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K897</accession>
    <name>A0A9J7K897_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21 22 23" type="primary">Nmnat3</name>
    </gene>
    <organism evidence="19 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21 22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21 22">17A/GY</strain>
            <tissue evidence="20 21 22">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:21361"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:21362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:22861"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:22862"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="RefSeq" id="XP_035299771.1">
        <property type="nucleotide sequence ID" value="XM_035443880.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299772.1">
        <property type="nucleotide sequence ID" value="XM_035443881.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299773.1">
        <property type="nucleotide sequence ID" value="XM_035443882.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299774.1">
        <property type="nucleotide sequence ID" value="XM_035443883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310778.1">
        <property type="nucleotide sequence ID" value="XM_035454887.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310781.1">
        <property type="nucleotide sequence ID" value="XM_035454890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310782.1">
        <property type="nucleotide sequence ID" value="XM_035454891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310784.1">
        <property type="nucleotide sequence ID" value="XM_035454893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K897"/>
    <dbReference type="GeneID" id="103160971"/>
    <dbReference type="CTD" id="349565"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF7">
        <property type="entry name" value="NICOTINAMIDE_NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="18">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035299771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035299772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035299773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035299774.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29907" checksum="2D7314106A81AD71" modified="2023-06-28" version="1">MKNRIPVVLLACGSFNPITNMHLRLFEVARDHLHQTGMYQVIEGIISPVNDSYGKKDLVASHHRVAMAQLALQTSDWIRVDPWESEQAQWMETVKVLRLIERSRSKTADYPVKHLPLHHHNQLLKSSAQMEDPDPSKTPSASAALPELKLLCGADVLKTFQTPNLWKDEHIQEIVEKFGLVCVSRRGHDPKGYILDSPILRQFQHNIHLAREPIQNEISATYIRKALGQGQSVKYLLPDTVIAYIRDHGLYSSDGSWTGKGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KEU8</accession>
    <name>A0A9J7KEU8_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 149 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ccdc149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC149 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027240509.1">
        <property type="nucleotide sequence ID" value="XM_027384708.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035307996.1">
        <property type="nucleotide sequence ID" value="XM_035452105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KEU8"/>
    <dbReference type="GeneID" id="100765586"/>
    <dbReference type="KEGG" id="cge:100765586"/>
    <dbReference type="CTD" id="91050"/>
    <dbReference type="OrthoDB" id="5917629at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019179">
        <property type="entry name" value="CC149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09789">
        <property type="entry name" value="CC149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_035307996.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="54105" checksum="CE92B05B0EB3D6A6" modified="2023-06-28" version="1">MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELRQRLGEVQGDNKLLRMTIAKQRLGDEEIGMRHFAAHEREDLVEQLERAKEQIESLEHDLQASVDELQDVKEERASYQDKVDRLNQELNHILGGHENRIIDVDALCMENRYLQERLKQLHEEVSLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSIADLKSLATALLETIHEKNMVIQHQRQTNRILGNRVAELEKKLRTLEVSGLWSLPGLSYNVSVGFGRGKDTILFSDQTLTTIQRSRSPLLKFVEQPTENKESTKDGEIQKQERDESCAAAEALTVPEDAEKPAVSSPTQPSNRNQCSHFHHPPLPQLPSEELNTVGKGTVQLTDGQEAAHLVTREAPLEEQRCEPGLSPPSLASQGECTTTLQDHLSSMQPEAKASSVEGDRGISEGGDMRSTVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3GRR6</accession>
    <name>G3GRR6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">LOC100753375</name>
        <name evidence="8" type="ORF">H671_3g8718</name>
        <name evidence="7" type="ORF">I79_000209</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="5"/>
    <dbReference type="EMBL" id="JH000004">
        <property type="protein sequence ID" value="EGV94060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE671062">
        <property type="protein sequence ID" value="ERE80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007650048.1">
        <property type="nucleotide sequence ID" value="XM_007651858.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027266424.1">
        <property type="nucleotide sequence ID" value="XM_027410623.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GRR6"/>
    <dbReference type="PaxDb" id="10029-XP_007609166.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001021644.1">
        <property type="protein sequence ID" value="ENSCGRP00001017400.1"/>
        <property type="gene ID" value="ENSCGRG00001017454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753375"/>
    <dbReference type="KEGG" id="cge:100753375"/>
    <dbReference type="eggNOG" id="KOG1584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163403"/>
    <dbReference type="OMA" id="FKSKMQD"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV94060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ERE80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001017400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027266424.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33609" checksum="A6A5B010F10BFFAB" modified="2011-11-16" version="1">MSERMNTTEIFDGIRFPGFMHTLESLKAACAFQFQDTDILLVTFPKSGTTWMQQVLSLIFCKGHLWPIHHLPNWARMPWIEQTSFSSLLPKLNSSWPRLLTSHLCAKVLAPALMKSKAKVVYMARNPKDAVVSFYHFHRIAGFLPDPGSFEDFVDEFLQGTGFFGSWFDHVKGWLGLQNDLNLLFVTYEELHQEPRRTIQKLCEFLGHSLRPEEEDVILEHCSFSFMSQSSMVNYSLVSKEIIDQSQGKFLRKGVVGDWREHFTPELDEKFKAVYQSKMGDSGLLLPWTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3GVB3</accession>
    <name>G3GVB3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 13 14">Cytohesin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">Cyth3</name>
        <name evidence="10" type="ORF">I79_001648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14">17A/GY</strain>
            <tissue evidence="13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000039">
        <property type="protein sequence ID" value="EGV95757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269389.1">
        <property type="nucleotide sequence ID" value="XM_027413588.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027296673.1">
        <property type="nucleotide sequence ID" value="XM_027440872.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299040.1">
        <property type="nucleotide sequence ID" value="XM_035443149.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315910.1">
        <property type="nucleotide sequence ID" value="XM_035460019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GVB3"/>
    <dbReference type="SMR" id="G3GVB3"/>
    <dbReference type="STRING" id="10029.G3GVB3"/>
    <dbReference type="PaxDb" id="10029-XP_007615072.1"/>
    <dbReference type="GeneID" id="100756495"/>
    <dbReference type="CTD" id="9265"/>
    <dbReference type="eggNOG" id="KOG0930">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3GVB3"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01252">
        <property type="entry name" value="PH_GRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000003">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000009">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF320">
        <property type="entry name" value="CYTOHESIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="9">
        <location>
            <begin position="11"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="216"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV95757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027269389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035299040.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40810" checksum="3BEA8FEC39D77E23" modified="2011-11-16" version="1">MTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDDFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFITMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3GVF2</accession>
    <name>G3GVF2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17 18 19" type="primary">Chst12</name>
        <name evidence="13" type="ORF">I79_001689</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17 18 19">17A/GY</strain>
            <tissue evidence="17 18 19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="EMBL" id="JH000039">
        <property type="protein sequence ID" value="EGV95796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003496345.1">
        <property type="nucleotide sequence ID" value="XM_003496297.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007647124.1">
        <property type="nucleotide sequence ID" value="XM_007648934.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269311.1">
        <property type="nucleotide sequence ID" value="XM_027413510.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269312.1">
        <property type="nucleotide sequence ID" value="XM_027413511.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027269313.1">
        <property type="nucleotide sequence ID" value="XM_027413512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GVF2"/>
    <dbReference type="STRING" id="10029.G3GVF2"/>
    <dbReference type="GlyGen" id="G3GVF2">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_003496345.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001239.1">
        <property type="protein sequence ID" value="ENSCGRP00001001214.1"/>
        <property type="gene ID" value="ENSCGRG00001000937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100762689"/>
    <dbReference type="KEGG" id="cge:100762689"/>
    <dbReference type="CTD" id="55501"/>
    <dbReference type="eggNOG" id="KOG4651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156614"/>
    <dbReference type="OMA" id="VPMLKMY"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050651">
        <property type="term" value="P:dermatan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF4">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV95796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027269311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027269312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027269313.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="49191" checksum="6522D7FB60E3A852" modified="2011-11-16" version="1">MTKPRLFRLWLVLGSALMILLIIVYWDNVGTAHFYLHTSLSRPHILEPLPTPGLGGENVFTSDVDEFLDTLLSSDAKQNDLSRRKTEQPPVLAPSKPVLSHMEENVRGYDWSTHDAQQNPDRDRQQAERRSLLRDFCANASLAFPTKDRTFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLDRGSPYRDPLDIPREHVHNSSTHLTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLRSLKVDSQLHFPPSYRNRTASSWEEDWFANIPLAWRQQLYKLYEADFVLFGYPKPENLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3GXI6</accession>
    <name>G3GXI6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">BET1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Golgi vesicular membrane-trafficking protein p18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">LOC113832635</name>
        <name evidence="25" type="synonym">Bet1</name>
        <name evidence="20" type="ORF">I79_002478</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24 25">17A/GY</strain>
            <tissue evidence="24 25">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with SNARE complex members GOSR2, SEC22B and STX5. Interacts with LMAN1/ERGIC53. Interacts with STX17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">cis-Golgi network membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the BET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000059">
        <property type="protein sequence ID" value="EGV95723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497004.1">
        <property type="nucleotide sequence ID" value="XM_003496956.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245655.1">
        <property type="nucleotide sequence ID" value="XM_027389854.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027245656.1">
        <property type="nucleotide sequence ID" value="XM_027389855.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GXI6"/>
    <dbReference type="STRING" id="10029.G3GXI6"/>
    <dbReference type="PaxDb" id="10029-XP_007630196.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018085.1">
        <property type="protein sequence ID" value="ENSCGRP00001013848.1"/>
        <property type="gene ID" value="ENSCGRG00001014879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761331"/>
    <dbReference type="GeneID" id="113832635"/>
    <dbReference type="KEGG" id="cge:100761331"/>
    <dbReference type="KEGG" id="cge:113832635"/>
    <dbReference type="CTD" id="10282"/>
    <dbReference type="eggNOG" id="KOG3385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163414"/>
    <dbReference type="OMA" id="KMDSARG"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000026">
        <property type="entry name" value="BET1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="19">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV95723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027245655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027245656.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13230" checksum="4F20653D72ACD76B" modified="2011-11-16" version="1">MRRAGLGEGGPPGNYGNYGYAGSGYNACEEENDRLTESLRSKVTAIKSLSIEIGHEVKNQNKLLAEMDSQFDSTTGFLGKTMGRLKILSRGSQTKLLCYMMLFSLFVFFVIYWIIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3H1M0</accession>
    <name>G3H1M0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Pleckstrin homology domain-containing family H member 1 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Pleckstrin-likey domain-containing family H member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Plekhh1</name>
        <name evidence="8" type="ORF">I79_004069</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH000107">
        <property type="protein sequence ID" value="EGV91867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498316.1">
        <property type="nucleotide sequence ID" value="XM_003498268.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274167.1">
        <property type="nucleotide sequence ID" value="XM_027418366.2"/>
    </dbReference>
    <dbReference type="STRING" id="10029.G3H1M0"/>
    <dbReference type="GlyGen" id="G3H1M0">
        <property type="glycosylation" value="2 sites"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007634960.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012881.1">
        <property type="protein sequence ID" value="ENSCGRP00001008739.1"/>
        <property type="gene ID" value="ENSCGRG00001010948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761047"/>
    <dbReference type="KEGG" id="cge:100761047"/>
    <dbReference type="CTD" id="57475"/>
    <dbReference type="eggNOG" id="KOG0248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYPIRYR"/>
    <dbReference type="OrthoDB" id="6285196at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13206">
        <property type="entry name" value="FERM_C-lobe_PLEKHH1_PLEKHH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13282">
        <property type="entry name" value="PH1_PLEKHH1_PLEKHH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF4">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="571"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="680"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="7">
        <location>
            <begin position="825"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="990"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV91867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027274167.1"/>
        </source>
    </evidence>
    <sequence length="1355" mass="150826" checksum="8DCC4B3075E855CC" modified="2011-11-16" version="1">MAEVKVEVASIDWQKRCLSLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKIKLSNLKNGDSTGSLHQKYQELLKAMQSKDELISQLEAQLEKQKQTRAEEAKIVQEKAAKIKEWVTVKLAELETENEHLKAYNQQLVEQVEALRDTLADLRMTPSEKLLVVPEGTPEGNPVPSGPRTQPVEQDSNTHTQILKVAVPAPSLGTLQNKDSMSEARSLEDLSSSMVYSGEIAEAKTLKSHPQREGSPSQLLEKPGSRKHVSASYRANLLTAPGGTFPGTKISSREGGPGSSLTLPKVRAPSNPRDSFQLAKRHHSQPQVGPGHFDHVVNIKIGALPALPLSGFSKSESRAKAREEAEKMEMEEPLPTGKQEERESLKPPRAALEEVELEKKPPTPPLHRFPSWESRIYAMATSGMQLSDVSSQSDAAWCASGPPALAFPGAFSGLVYKNVTVPVYTALKGKATQISNVPFVDESSGSDDDCSSQASFRMSVPCSEYRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGEALEKSGYLLKMGSRVKTWKRRWFVLRQGQILYYKSPSDVIRKPQGQVDLNSHCQIVRGEGAQTFQLISENKTYYLTAESPSLLEEWIRVLQSLLKVQVIGPPALHQGGAKPTVKGWLTKVKHGHSKLVWCALVGKTFYYYRSHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTGRLLSSHCTLVIHPPEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTVYEQLIGKLMDGEGDPDSPLWRHPMLCYSRDGLCNSLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRNETGQYATYCQRAVERTLQTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFANGTYQVVGFDGSSTVDEFLQRLNQETGMRKPSQSGFALFTDDPSGRDLEHCLQGRVKICDAISKWEQTLKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETERERLLLAFQTSGEIVAGRFPVTKELALEMAALMAQVEYGDLEKPVLPGPGGTPPAKAQHLLQQILDRFYPKRYRNGAHPEQLRHLADTMATKWAALQGCSPSECIRIYLTVARKWPLFGAKLFAAQPAQLSSKENTLVWIAVNEDGVSILDHHTMQVHITYPYSSVTTFGGCKDDFMLVIRSIPDQSSGKTHIDKLIFKMPAPKITETTFMMASYMNHCSATVNLSSKLPAARQPRDLDGQFFASASCTKGPALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3H3M3</accession>
    <name>G3H3M3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Synaptotagmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Syt2</name>
        <name evidence="16" type="ORF">I79_004812</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Chromaffin granule membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">Secretory vesicle</location>
            <location evidence="1 13">Synaptic vesicle membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000127">
        <property type="protein sequence ID" value="EGW02163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007632451.3">
        <property type="nucleotide sequence ID" value="XM_007634261.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273911.2">
        <property type="nucleotide sequence ID" value="XM_027418110.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H3M3"/>
    <dbReference type="STRING" id="10029.G3H3M3"/>
    <dbReference type="PaxDb" id="10029-XP_007633922.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017938.1">
        <property type="protein sequence ID" value="ENSCGRP00001013701.1"/>
        <property type="gene ID" value="ENSCGRG00001014761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761723"/>
    <dbReference type="KEGG" id="cge:100761723"/>
    <dbReference type="CTD" id="127833"/>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157586"/>
    <dbReference type="OMA" id="RCILGCS"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903861">
        <property type="term" value="P:positive regulation of dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21964">
        <property type="entry name" value="Syt2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000016">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF223">
        <property type="entry name" value="SYNAPTOTAGMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="139"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="270"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW02163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027273911.2"/>
        </source>
    </evidence>
    <sequence length="419" mass="46993" checksum="837024186AC4D556" modified="2011-11-16" version="1">MRNIFKRNQEPIVAPATTTATMPVRPADNSTESTGTGESQEDMFAKLKDKFFNEINKIPLPPWALIAMAVVAGLLLLTCCVCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3H5U7</accession>
    <name>G3H5U7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Mrpl10</name>
        <name evidence="10" type="ORF">I79_005689</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000166">
        <property type="protein sequence ID" value="EGW05265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003499617.1">
        <property type="nucleotide sequence ID" value="XM_003499569.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027279988.1">
        <property type="nucleotide sequence ID" value="XM_027424187.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H5U7"/>
    <dbReference type="STRING" id="10029.G3H5U7"/>
    <dbReference type="PaxDb" id="10029-XP_007615536.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031332.1">
        <property type="protein sequence ID" value="ENSCGRP00001027085.1"/>
        <property type="gene ID" value="ENSCGRG00001024199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100754497"/>
    <dbReference type="KEGG" id="cge:100754497"/>
    <dbReference type="CTD" id="124995"/>
    <dbReference type="eggNOG" id="KOG4241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000603"/>
    <dbReference type="OMA" id="RHRLYKH"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000006">
        <property type="entry name" value="39S ribosomal protein L10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10 14" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGW05265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027279988.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29135" checksum="E97E16D7E34AB1B8" modified="2011-11-16" version="1">MAAAVAGILRGGVPPRAAWLPTLQTVRHGSKAVTRHPRVMHFERQKLMALTEYIPPKPAINPRCLPPPPKPPKEESGLIHLLRRDIVAVFRDNRMIAVCQNVAMSAEDKLLLRHRLRKHNILIKIFPNEVLKPFLGDSKYQNLLPLFIGHNMLLVSEEPKVKEMVRILKSVPFLPLLGGCVDDTILSRQGFVEYAKLPSLDLLQGELVGGLTGLMAQTHYLLQHQPAQLTSLLDQYIKQQQEGESTTSASGTPPPSDLTPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3H6M3</accession>
    <name>G3H6M3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 22">Exonuclease 1</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29 30 31" type="primary">Exo1</name>
        <name evidence="26" type="ORF">I79_005988</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29 30 31" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29 30 31">17A/GY</strain>
            <tissue evidence="29 30 31">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="22">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'-&gt;3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'-&gt;5' exonuclease activity and suppress the 5'-&gt;3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'-&gt;3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="EMBL" id="JH000177">
        <property type="protein sequence ID" value="EGW05760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007638783.1">
        <property type="nucleotide sequence ID" value="XM_007640593.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007638784.1">
        <property type="nucleotide sequence ID" value="XM_007640594.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016829859.1">
        <property type="nucleotide sequence ID" value="XM_016974370.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274693.1">
        <property type="nucleotide sequence ID" value="XM_027418892.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274694.1">
        <property type="nucleotide sequence ID" value="XM_027418893.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274695.1">
        <property type="nucleotide sequence ID" value="XM_027418894.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H6M3"/>
    <dbReference type="STRING" id="10029.G3H6M3"/>
    <dbReference type="PaxDb" id="10029-XP_007637772.1"/>
    <dbReference type="GeneID" id="100772338"/>
    <dbReference type="CTD" id="9156"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3H6M3"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 22" id="KW-0228">DNA excision</keyword>
    <keyword evidence="17 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14 22" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11 22 26" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="12 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="25">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="24">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="514"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="720"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
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            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
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            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGW05760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_027274693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_027274694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027274695.1"/>
        </source>
    </evidence>
    <sequence length="878" mass="96271" checksum="B9879104820036FD" modified="2011-11-16" version="1">MGIQGLLQFIKEASEPINVKKYKGQAVAVDTYCWLHKGAISCAEKLAKGEPTDKYVGFCMKFVNMLLSHGVKPILVFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARECFTRSVNITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLLAFGCKKVILKMDQFGNGLEVDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLKLANNPDIVKVIKKIGQYLKMNITVPEDYITGFIRANNTFLYQLVFDPIQRKLVPLNAYGNDVDPETLSYAGQYVDDSEALQRALGNRDINTFEQIDDYSPDTMPVHSRSHSWNDKSCQKSPVANSIWHRNYCPRREVNGVSHAPPLTENSSTVGLKQVISTKGLNLPRKSSMVKRPRNEALSEDDLLSQYSSFTKKTKKNSCGDNAAFSSSEMSAPILDDGTAHKTDAYTPSRTRNKFAVFLRRKNEKSGAVVVPGTRSRFFCSSPDFDDFEPKKASSQPLNETAVPGKATTSLRAPDCPGTDGLGAPDCPGTDGLRAPDSPGTDGLREPDSPGTDGLGALDCPDTDGQKLVGISGTQDPSAQIPGSVTVSPDEAQSSKTSKFVDTVSPFSLGTLRSCFNWSRTLRDFSRTPSPSSSTVLQQFRRKSESPSCLPENCALTDTCHSKSEMSNAKAPPLHEVGWSTPSRESIDSLCSLNASNLSQPSSKDSDSEESDCNSKSLDNQGNQNFEQLLPPFSKTDTLARNKVPGLCRSSSTDSLSTTKIKPLVPARVSGLSKKPGSVQKRKHHDAENKPGLQIKISELWKNFGFKKDSEKLPSCKKPLSPVKDNIQLTPESEDELFNKPECARAQRAIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3H9D8</accession>
    <name>G3H9D8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
            <ecNumber evidence="5">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10 11 12 13" type="primary">Pigw</name>
        <name evidence="6" type="ORF">I79_007006</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10 11 12">17A/GY</strain>
            <tissue evidence="10 11 12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="5"/>
    <dbReference type="EMBL" id="JH000227">
        <property type="protein sequence ID" value="EGV94927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003500776.1">
        <property type="nucleotide sequence ID" value="XM_003500728.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639658.1">
        <property type="nucleotide sequence ID" value="XM_007641468.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639659.1">
        <property type="nucleotide sequence ID" value="XM_007641469.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007639660.1">
        <property type="nucleotide sequence ID" value="XM_007641470.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282207.1">
        <property type="nucleotide sequence ID" value="XM_027426406.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282208.1">
        <property type="nucleotide sequence ID" value="XM_027426407.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282209.1">
        <property type="nucleotide sequence ID" value="XM_027426408.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282210.1">
        <property type="nucleotide sequence ID" value="XM_027426409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H9D8"/>
    <dbReference type="STRING" id="10029.G3H9D8"/>
    <dbReference type="PaxDb" id="10029-XP_007631898.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001001829.1">
        <property type="protein sequence ID" value="ENSCGRP00001001619.1"/>
        <property type="gene ID" value="ENSCGRG00001001433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759511"/>
    <dbReference type="KEGG" id="cge:100759511"/>
    <dbReference type="CTD" id="284098"/>
    <dbReference type="eggNOG" id="KOG0411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013520"/>
    <dbReference type="OMA" id="GLYVMQP"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV94927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027282207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027282208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027282209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027282210.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56538" checksum="D7F2276E0E404551" modified="2011-11-16" version="1">MSQKQMKEAFVSNLNGTSVLEITQGLCFPAFCILCRGLLIIFSQHLCSFSHNWSTWFLMDFVVLIVPLVITLTILSSFILLENLMVTVCVAWLLYQIYQRRTCYAKVPAQKVFANFLKISLESEYNPAITGYRVINSIFTAIAILAVDFPLFPRRFAKTELYGTGAMDYGVGGFIFGAAMVCPEVRRKCIVGSRFNYLRKSLYSVWPLVFLGMGRLVVIKSIGYQEHLTEYGVHWNFFFTIIVVKLVTSLLLTIFPLNKSWVVAVSITVLYQLALDFTPLKGVILYGTDGSGTRVGLLNANREGIISTLGYVTIHMAGVQTGLYVLKVRTHIRDWIKVTCCILLVAVSFFISLHIVQVNIEAVSRRMANLAFCMWVVASSLMLLSCLLLSDIILSFAKFLIKGALVPCSWKLIQLPATNKKHSESLILETEKEDPSLCLITALNRNQLFFFLLSNITTGLINLTVDTLHSGASWTLVVLCTYMFTNCLVIYVLDLQGKTIKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3HKW1</accession>
    <name>G3HKW1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15">Nuclear factor of activated T-cells, cytoplasmic 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Nfatc3</name>
        <name evidence="12" type="ORF">I79_011343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000471">
        <property type="protein sequence ID" value="EGW10098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504360.1">
        <property type="nucleotide sequence ID" value="XM_003504312.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261694.1">
        <property type="nucleotide sequence ID" value="XM_027405893.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HKW1"/>
    <dbReference type="STRING" id="10029.G3HKW1"/>
    <dbReference type="PaxDb" id="10029-XP_007610063.1"/>
    <dbReference type="GeneID" id="100760989"/>
    <dbReference type="CTD" id="4775"/>
    <dbReference type="eggNOG" id="ENOG502QWQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HKW1"/>
    <dbReference type="OMA" id="QPMPYQT"/>
    <dbReference type="OrthoDB" id="5346094at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01178">
        <property type="entry name" value="IPT_NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07881">
        <property type="entry name" value="RHD-n_NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000040">
        <property type="entry name" value="Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000001">
        <property type="entry name" value="Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008366">
        <property type="entry name" value="NFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533">
        <property type="entry name" value="NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533:SF6">
        <property type="entry name" value="NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01789">
        <property type="entry name" value="NUCFACTORATC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHD" evidence="11">
        <location>
            <begin position="416"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="861"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="886"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="917"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGW10098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027261694.1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="115497" checksum="824A309894761BFA" modified="2011-11-16" version="1">MTTANCGAHDELDFKLVFGEDGAPAPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGHKNYEGTGDISESKYSPLGGSKPFECPSIQITSISPNCHQGTDVHEDDLQINDPEREYLERPSRDHLYLPLEPSYRESSFSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEDSWQQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTASVHTGSGLGPAPFPFQYCVETDIPLKTRKTSEDQAVILSGKLEICSDDQGSLSPSRETSVDDALGSPYALKKDSSGDQFLSVPSPFTWSKPKPGHTPVFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSVTGHPHDSVLSASRSLICPIQPAYASMITSSHLPQLQCGDEGASKEQHIIPSSVMHQPFQVTSTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSTLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNTGQRSLSSPVADQVTGQPSSHLQPITYCPSHPGSAPAASPAASHPLANSPLSGPSSSQLQSMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQEGLSALSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQISVSQGPEVSRDDPLPRPNSPNLGRSDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3HUZ3</accession>
    <name>G3HUZ3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maspardin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Spg21</name>
        <name evidence="9" type="ORF">I79_014766</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role as a negative regulatory factor in CD4-dependent T-cell activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with CD4. Interacts with ALDH16A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JH000758">
        <property type="protein sequence ID" value="EGW10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003507199.1">
        <property type="nucleotide sequence ID" value="XM_003507151.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267126.1">
        <property type="nucleotide sequence ID" value="XM_027411325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HUZ3"/>
    <dbReference type="STRING" id="10029.G3HUZ3"/>
    <dbReference type="ESTHER" id="crigr-g3huz3">
        <property type="family name" value="Maspardin-ACP33-SPG21_like"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007608122.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028617.1">
        <property type="protein sequence ID" value="ENSCGRP00001024371.1"/>
        <property type="gene ID" value="ENSCGRG00001022317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751665"/>
    <dbReference type="KEGG" id="cge:100751665"/>
    <dbReference type="CTD" id="51324"/>
    <dbReference type="eggNOG" id="ENOG502QPSD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007857"/>
    <dbReference type="OMA" id="CYVQPQK"/>
    <dbReference type="OrthoDB" id="10264550at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042609">
        <property type="term" value="F:CD4 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048668">
        <property type="term" value="P:collateral sprouting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050905">
        <property type="term" value="P:neuromuscular process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042551">
        <property type="term" value="P:neuron maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070849">
        <property type="term" value="P:response to epidermal growth factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000040">
        <property type="entry name" value="SPG21, maspardin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026151">
        <property type="entry name" value="Maspardin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913">
        <property type="entry name" value="ACID CLUSTER PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913:SF0">
        <property type="entry name" value="MASPARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="87"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGW10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027267126.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34966" checksum="9E312FCB0865CE15" modified="2011-11-16" version="1">MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLALSQEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3HXC7</accession>
    <name>G3HXC7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Basic helix-loop-helix domain containing, class B9</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4 5 10">protein BHLHb9</fullName>
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    </protein>
    <gene>
        <name evidence="6 10 11 12 13" type="primary">LOC100767015</name>
        <name evidence="5" type="ORF">H671_xg20699</name>
        <name evidence="4" type="ORF">I79_015646</name>
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    <organism evidence="4 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10 11 12">17A/GY</strain>
            <tissue evidence="10 11 12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPRASP family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGW02721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ERE63539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR ASSOCIATED SORTING PROTEIN 3"/>
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        <location>
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            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3HXZ6</accession>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
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    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
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    </reference>
    <reference evidence="10" key="5">
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="EMBL" id="JH000898">
        <property type="protein sequence ID" value="EGW08475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027408863.2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:neuron differentiation"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="4.10.280.10">
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
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        <property type="entry name" value="ACHAETE-SCUTE HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGW08475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027264664.1"/>
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    </evidence>
    <sequence length="193" mass="20352" checksum="E51A341072531F6A" modified="2011-11-16" version="1">MDGGSLPRLMPASPGVAGTCAARRRPASPELLRCSRRRRSGTTEAGGGSAAVARRNERERNRVKLVNLGFQALRQHVPHGGASKKLSKVETLRSAVEYIRALQRLLAEHDAVRAALAGGLLTSDTRPSAARAPPVTSPASASLSCTSSSPDRRGSSEPGSPRSAYSSEDSGCEGELSPVERELLDFSSWLGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G3I5L3</accession>
    <name>G3I5L3_CRIGR</name>
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        <recommendedName>
            <fullName evidence="28">Annexin</fullName>
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        <name evidence="31 35" type="primary">Anxa1</name>
        <name evidence="30" type="ORF">H671_3g10393</name>
        <name evidence="29" type="ORF">I79_018766</name>
    </gene>
    <organism evidence="29 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
            <tissue evidence="35">Liver</tissue>
        </source>
    </reference>
    <reference evidence="31" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="27">Homodimer; non-covalently linked. Homodimer; linked by transglutamylation. Homodimers linked by transglutamylation are observed in placenta, but not in other tissues. Interacts with S100A11. Heterotetramer, formed by two molecules each of S100A11 and ANXA1. Interacts with DYSF. Interacts with EGFR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Phagocytic cup</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">Secretory vesicle lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Extracellular exosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="28">The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 28">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001310">
        <property type="protein sequence ID" value="EGW02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE673090">
        <property type="protein sequence ID" value="ERE78391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510519.1">
        <property type="nucleotide sequence ID" value="XM_003510471.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027262348.1">
        <property type="nucleotide sequence ID" value="XM_027406547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I5L3"/>
    <dbReference type="SMR" id="G3I5L3"/>
    <dbReference type="STRING" id="10029.G3I5L3"/>
    <dbReference type="PaxDb" id="10029-XP_007620413.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025473.1">
        <property type="protein sequence ID" value="ENSCGRP00001021229.1"/>
        <property type="gene ID" value="ENSCGRG00001020144.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768079"/>
    <dbReference type="KEGG" id="cge:100768079"/>
    <dbReference type="CTD" id="301"/>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3I8B8</accession>
    <name>G3I8B8_CRIGR</name>
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        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Rasl10b</name>
        <name evidence="13" type="ORF">I79_019781</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JH001492">
        <property type="protein sequence ID" value="EGW14909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035303918.1">
        <property type="nucleotide sequence ID" value="XM_035448027.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317617.1">
        <property type="nucleotide sequence ID" value="XM_035461726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I8B8"/>
    <dbReference type="SMR" id="G3I8B8"/>
    <dbReference type="STRING" id="10029.G3I8B8"/>
    <dbReference type="PaxDb" id="10029-XP_007608649.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011995.1">
        <property type="protein sequence ID" value="ENSCGRP00001007910.1"/>
        <property type="gene ID" value="ENSCGRG00001010269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100775094"/>
    <dbReference type="KEGG" id="cge:100775094"/>
    <dbReference type="CTD" id="91608"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160764"/>
    <dbReference type="OMA" id="IEMEIHI"/>
    <dbReference type="OrthoDB" id="299781at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090277">
        <property type="term" value="P:positive regulation of peptide hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003050">
        <property type="term" value="P:regulation of systemic arterial blood pressure by atrial natriuretic peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04142">
        <property type="entry name" value="RRP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000625">
        <property type="entry name" value="Ras-like protein family member 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052661">
        <property type="entry name" value="Ras-like_GTPase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350:SF1">
        <property type="entry name" value="RAS-LIKE PROTEIN FAMILY MEMBER 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW14909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035303918.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23199" checksum="B5071A882740A1CC" modified="2011-11-16" version="1">MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADACCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3IA73</accession>
    <name>G3IA73_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">E3 ubiquitin-protein ligase RNF13</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">RING finger protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31 34 35 36" type="primary">Rnf13</name>
        <name evidence="30" type="ORF">I79_020489</name>
    </gene>
    <organism evidence="30 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="33" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="34 35 36" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="34 35 36">17A/GY</strain>
            <tissue evidence="34 35 36">Liver</tissue>
        </source>
    </reference>
    <reference evidence="31" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Also involved in protein trafficking and localization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with ERN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Late endosome membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Nucleus inner membrane</location>
            <topology evidence="22">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JH001671">
        <property type="protein sequence ID" value="EGW12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511923.1">
        <property type="nucleotide sequence ID" value="XM_003511875.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007650557.1">
        <property type="nucleotide sequence ID" value="XM_007652367.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027239943.1">
        <property type="nucleotide sequence ID" value="XM_027384142.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247447.1">
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        <name type="scientific">Cricetulus griseus</name>
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        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
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                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="EMBL" id="JH002051">
        <property type="protein sequence ID" value="EGW14156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE685105">
        <property type="protein sequence ID" value="ERE65298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003512914.1">
        <property type="nucleotide sequence ID" value="XM_003512866.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027287644.1">
        <property type="nucleotide sequence ID" value="XM_027431843.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IDF9"/>
    <dbReference type="STRING" id="10029.G3IDF9"/>
    <dbReference type="GlyGen" id="G3IDF9">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007608266.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030725.1">
        <property type="protein sequence ID" value="ENSCGRP00001026479.1"/>
        <property type="gene ID" value="ENSCGRG00001023787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763541"/>
    <dbReference type="KEGG" id="cge:100763541"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004175"/>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGW14156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE65298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027287644.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31179" checksum="4BDF5DDBA9BCDF9D" modified="2011-11-16" version="1">MGSSASTPAAAANTPNASDHQPPSRPSGCPMHERQKKDCPVTAVASDPTSESKAHSAPAHQDRAYEYVECPVTGAATKDKENLDPSNLMPPPNQTPSPDQPFALSTSREESSIPRADSEKKWVYPSEQMFWNAMLRKGWKWKDDDISQKDMYNIIRIHNQNNEQAWREILKWEALHARECPCGPSLVRFGGKARKYSPRARIRSWMGYELPFDRHDWIINRCGTEVRYVIDYYDGGEVNKDYQFTILDVRPALDSFSAVWDRMKVAWWRWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3IN18</accession>
    <name>G3IN18_CRIGR</name>
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            <fullName evidence="9">Large ribosomal subunit protein uL2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">60S ribosomal protein L8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Rpl8</name>
        <name evidence="15" type="ORF">I79_025329</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the large ribosomal subunit. Interacts with CRY1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH005324">
        <property type="protein sequence ID" value="EGW14401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003515710.1">
        <property type="nucleotide sequence ID" value="XM_003515662.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027260085.1">
        <property type="nucleotide sequence ID" value="XM_027404284.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IN18"/>
    <dbReference type="SMR" id="G3IN18"/>
    <dbReference type="STRING" id="10029.G3IN18"/>
    <dbReference type="PaxDb" id="10029-XP_007610714.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003601.1">
        <property type="protein sequence ID" value="ENSCGRP00001002653.1"/>
        <property type="gene ID" value="ENSCGRG00001002982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753709"/>
    <dbReference type="KEGG" id="cge:100753709"/>
    <dbReference type="CTD" id="6132"/>
    <dbReference type="eggNOG" id="KOG2309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153244"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000581">
        <property type="entry name" value="Ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_uL2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 15 19" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="14">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="13">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGW14401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027260085.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28025" checksum="CE1610449749318B" modified="2011-11-16" version="1">MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q60436</accession>
    <name>SRRT_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Serrate RNA effector molecule homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Arsenite-resistance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SRRT</name>
        <name type="synonym">ARS2</name>
        <name type="synonym">ASR2</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Carcinogenesis" volume="20" first="311" last="316">
            <title>Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis.</title>
            <authorList>
                <person name="Rossman T.G."/>
                <person name="Wang Z."/>
            </authorList>
            <dbReference type="PubMed" id="10069470"/>
            <dbReference type="DOI" id="10.1093/carcin/20.2.311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>PRELIMINARY FUNCTION</scope>
        <source>
            <tissue>Lung</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase (By similarity). Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Interacts with CASP8AP2, ERBB4, NCBP1/CBP80 and DROSHA. Interacts with LUZP4. Interacts with NCBP2/CBP20 and NCBP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAA83777" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="U41500">
        <property type="protein sequence ID" value="AAA83777.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q60436"/>
    <dbReference type="SMR" id="Q60436"/>
    <dbReference type="PaxDb" id="10029-NP_001233648.1"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097150">
        <property type="term" value="P:neuronal stem cell population maintenance"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000220964" description="Serrate RNA effector molecule homolog">
        <location>
            <begin position="1" status="less than"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="modified residue" description="Omega-N-methylarginine" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="modified residue" description="Omega-N-methylarginine" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="modified residue" description="Omega-N-methylarginine" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q99MR6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9BXP5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="306" mass="34267" checksum="552C89175C005F94" modified="2008-03-18" version="3" fragment="single">HKEEELLGSSGGPPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDTEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEMKPAQPPGPAQILPPGLTPGLPYPHQTPQGLMPYGQPALPIFGYGAGAVRPAVPTGGPPYPHGPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ICC0</accession>
    <name>A0A061ICC0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin-15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cadherin-14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Muscle cadherin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Cdh15</name>
        <name evidence="23" type="ORF">H671_3g9578</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
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        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cell membrane</location>
            <topology evidence="1 18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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        <location>
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        </location>
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        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Mammalia</taxon>
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        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
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            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
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    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
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                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15407">
        <property type="entry name" value="7tmA_OR5B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE79557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027262585.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34863" checksum="FFF80766DEC436EB" modified="2014-09-03" version="1">MQNISEVTEFILVGLTDVPELQVPLFIIFTLVYSTTLLGNLGMIMLILLDSRLHNPMYIFLSNLSLVDCVYASAVTPKVIEGFVIEHKVMSYNACAAQMFFLIAFAIIEGFLIASMAFDRHAAVCKPLHYSTTMTTTKCALLVAGSYISGLLQSSIHVAFTFHLSFCHSNVINHFFCDIPPLLAISCSDIYNNEIILFMLAAFNVTLTILVILNSYLLIFIAILRMRSAEGRKKAISTCASHLTTVSIFYGTIIFMYLQPSSSHSMDTDKVASVFYTMIIPMLNPLVYSLRNKDVKNAFKKIAVKALASLELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IIA7</accession>
    <name>A0A061IIA7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">catechol O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Catechol O-methyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100751123</name>
        <name evidence="14" type="ORF">H671_3g8565</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function. Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33566"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:134251"/>
            <dbReference type="EC" id="2.1.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:17878"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="2"/>
    <dbReference type="EMBL" id="KE670869">
        <property type="protein sequence ID" value="ERE80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263681.1">
        <property type="nucleotide sequence ID" value="XM_027407880.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IIA7"/>
    <dbReference type="GeneID" id="100751123"/>
    <dbReference type="KEGG" id="cge:100751123"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042424">
        <property type="term" value="P:catecholamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000054">
        <property type="entry name" value="Catechol O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF1">
        <property type="entry name" value="TRANSMEMBRANE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1009">Hearing</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 17" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ERE80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027263681.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28921" checksum="A7010208A9550EB2" modified="2014-09-03" version="1">MSPAIALAFLPLVVTLLVRYRHHFRLLVSTVLLRSFRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLNHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGSRLLTVERDPRTAAVAEKLIRLAGFDEQMVELIVGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPKDATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYSGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7GLU6</accession>
    <name>A0A3L7GLU6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal sarcosine oxidase</fullName>
            <ecNumber evidence="3">1.5.3.1</ecNumber>
            <ecNumber evidence="10">1.5.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">L-pipecolate oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">L-pipecolic acid oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Pipox</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Metabolizes sarcosine, L-pipecolic acid and L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-pipecolate + O2 = L-1-piperideine-6-carboxylate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58769"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="EC" id="1.5.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sarcosine + O2 + H2O = formaldehyde + glycine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:13313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="EC" id="1.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.1" evidence="3"/>
    <dbReference type="EC" id="1.5.3.7" evidence="10"/>
    <dbReference type="RefSeq" id="XP_003511196.1">
        <property type="nucleotide sequence ID" value="XM_003511148.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027282428.1">
        <property type="nucleotide sequence ID" value="XM_027426627.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7GLU6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000070.1">
        <property type="protein sequence ID" value="ENSCGRP00001000046.1"/>
        <property type="gene ID" value="ENSCGRG00001000071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100765858"/>
    <dbReference type="KEGG" id="cge:100765858"/>
    <dbReference type="CTD" id="51268"/>
    <dbReference type="GeneTree" id="ENSGT00390000011000"/>
    <dbReference type="OMA" id="WPMLWAH"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033514">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via L-pipecolate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000189">
        <property type="entry name" value="Monomeric sarcosine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008425">
        <property type="entry name" value="PRK11259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01377">
        <property type="entry name" value="soxA_mon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027282428.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43788" checksum="DE9727E130E45BCB" modified="2019-02-13" version="1">MTAQKGLWDAIVIGAGIQGCFTAYHLAKHSKKVLLLEQFFLPHSRGSSHGQSRIIRKAYPEDFYTRMMDECYQTWAQLEHETGAQLHRQTELLLLGMKDNPELKTIQATLSRQGIDHGCLSSEDLKQRFPNIQFTRGEVGLLDKTGGVLYADKALRALQHVICQLGGTVCDGEKVVEIRPGLPVTVKTTLKSYQANSLVITAGPWTNQILRPLGIELPLQTLRINVCYYREKVPGSYSVSQAFPCILSLDLAPHHIYGLPASEYPGLMKVCYHHGDSVDPEERDCPTTFSDIQDVQILRHFVRDHLPGLRPEPDIMERCMYTNTPDKHFILDCHPKYDNIVIGAGFSGHGFKLAPVVGKILYELSMKVAPSYDLAPFRMSRFSTLSKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7H7I6</accession>
    <name>A0A3L7H7I6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11 14">C-type lectin domain family 2 member D11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">LOC100761692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027285609.1">
        <property type="nucleotide sequence ID" value="XM_027429808.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7H7I6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018673.1">
        <property type="protein sequence ID" value="ENSCGRP00001014436.1"/>
        <property type="gene ID" value="ENSCGRG00001015316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761692"/>
    <dbReference type="KEGG" id="cge:100761692"/>
    <dbReference type="GeneTree" id="ENSGT00940000163004"/>
    <dbReference type="OrthoDB" id="8935730at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046703">
        <property type="term" value="F:natural killer cell lectin-like receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF19">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 2 MEMBER D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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        <location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014436.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027285609.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24168" checksum="E38CAF320BB3FDEE" modified="2019-02-13" version="1">MGADQPAEAFVGMLGTTHRLQEGEMGKKLQGQCFRIVSVESPVKLYCCYGVITVLTVAVFALSVALSVRRSEQTPDKYTYAFCPRNWIGFGSKCFYFSENTNDWTFSQNFCKEQEAHLAQFDSDEELEFLKRYKGAFDYWIGLRRESPEHPWMWTDNTQYNSSVSIRGVEEYAYLNNNGISSARVYADRRWICSKPSSYALQCQIPFSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HEF9</accession>
    <name>A0A3L7HEF9_CRIGR</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
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    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="Ensembl" id="ENSCGRT00001011446.1">
        <property type="protein sequence ID" value="ENSCGRP00001007412.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cge:100758175"/>
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    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="KV6CHANNEL"/>
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    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
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    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="300"/>
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        </location>
    </feature>
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            <end position="460"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSCGRP00001007412.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035302005.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="57962" checksum="D6121B5AA1529263" modified="2019-02-13" version="1">MTLLPGDNSDYDYSALSCASDTSFHPAFFPQRQAIKGVFYRRAQRLRPQDDLHQGSSLGDRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREGEEELLDSEDQDTEGPSASEGRLGRCMRKLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVLIRRAQYLIKTKSQLSGMSQDSDILFGSASSDTRDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HSE0</accession>
    <name>A0A3L7HSE0_CRIGR</name>
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            <fullName evidence="2">Tetratricopeptide repeat protein 36</fullName>
        </recommendedName>
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        <name evidence="5 8" type="primary">Ttc36</name>
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    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
            <tissue evidence="8">Liver</tissue>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003510560.1">
        <property type="nucleotide sequence ID" value="XM_003510512.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027267794.1">
        <property type="nucleotide sequence ID" value="XM_027411993.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HSE0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030950.1">
        <property type="protein sequence ID" value="ENSCGRP00001026704.1"/>
        <property type="gene ID" value="ENSCGRG00001023946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758106"/>
    <dbReference type="KEGG" id="cge:100758106"/>
    <dbReference type="CTD" id="143941"/>
    <dbReference type="OMA" id="CNQMLCE"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021954">
        <property type="term" value="P:central nervous system neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902915">
        <property type="term" value="P:negative regulation of protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000213">
        <property type="entry name" value="Tetratricopeptide repeat domain 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_027267794.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20341" checksum="EF2D8B010EE54207" modified="2019-02-13" version="1">MGTPNDQAVLQAIFNPNTPFGDVIDLDLEEAKKEDEDGVFPQEQLEQSKALELQGVRAAEAGDLHTALEKFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVTLSGGQGRAARQSFVQRGLLARLQGRDDDARRDFEQAARLGSPFARRQLVLLNPYAALCNRMLADMMGQLRAPSNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LBU4</accession>
    <name>A0A8C2LBU4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">T-cell surface glycoprotein CD8 beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">Cd8b</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Forms disulfide-linked heterodimers with CD8A at the cell surface. Interacts with CD3D; this interaction couples TCR-CD3 with CD8. Interacts with LCK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035304347.1">
        <property type="nucleotide sequence ID" value="XM_035448456.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312713.1">
        <property type="nucleotide sequence ID" value="XM_035456822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LBU4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002349.1">
        <property type="protein sequence ID" value="ENSCGRP00001001921.1"/>
        <property type="gene ID" value="ENSCGRG00001001895.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769972"/>
    <dbReference type="KEGG" id="cge:100769972"/>
    <dbReference type="CTD" id="926"/>
    <dbReference type="OMA" id="RLWLRIH"/>
    <dbReference type="OrthoDB" id="9394844at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042288">
        <property type="term" value="F:MHC class I protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07700">
        <property type="entry name" value="IgV_CD8_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000645">
        <property type="entry name" value="T-cell surface glycoprotein CD8 beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042414">
        <property type="entry name" value="CD8B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11292">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11292:SF7">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0732">Signal</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678448" description="T-cell surface glycoprotein CD8 beta chain" evidence="14">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001001921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035304347.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="22953" checksum="5E99883746559020" modified="2022-01-19" version="1">MQPWLWLVFGVKLAALWSSSALLQTPRSLTVLTNQVAKVSCEAKTLPKTTLIYWLRQRRGPTKDKHFEFLASWNPSKGVATPGEGVKKESINVFSDITRYILNLTSVKLEDSGTYFCMMVGSPQLIFGSGTELSVVDALSTTAQTTKKTVIKKKQCPVPNPKAQKGLTCGLITLSLLVASLLVLLVSLGVAVHLHCLRRKARIHFMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LN84</accession>
    <name>A0A8C2LN84_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GID complex subunit 4, VID24 homolog</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Glucose-induced degradation protein 4 homolog isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">Gid4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
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        <property type="nucleotide sequence ID" value="XM_027427296.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C2LN84"/>
    <dbReference type="SMR" id="A0A8C2LN84"/>
    <dbReference type="Ensembl" id="ENSCGRT00001010660.1">
        <property type="protein sequence ID" value="ENSCGRP00001006755.1"/>
        <property type="gene ID" value="ENSCGRG00001009186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755044"/>
    <dbReference type="KEGG" id="cge:100755044"/>
    <dbReference type="CTD" id="79018"/>
    <dbReference type="GeneTree" id="ENSGT00500000044930"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="GOC"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
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    <evidence type="ECO:0000256" key="2">
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        <source>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027283097.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24833" checksum="1254AD821AFDCAE3" modified="2022-01-19" version="1">MPVRTECPPPAGASATSAASLIPPPPINTQQPGVATSLLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTRKWDADEDVDRKHWGKFLAFYQYAKSFNSDDFDYEELKNGDYVFMRWKEQFLVPDHTIKDISGASFAGFYYICFQKSAASIEGYYYHRSSEWYQSLNLTHVPEHSAPIYEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LPH3</accession>
    <name>A0A8C2LPH3_CRIGR</name>
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        <recommendedName>
            <fullName evidence="8">Forkhead box protein O1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Forkhead box protein O1A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Forkhead in rhabdomyosarcoma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Foxo1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027250747.1">
        <property type="nucleotide sequence ID" value="XM_027394946.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LPH3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001011807.1">
        <property type="protein sequence ID" value="ENSCGRP00001007738.1"/>
        <property type="gene ID" value="ENSCGRG00001010126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768647"/>
    <dbReference type="KEGG" id="cge:100768647"/>
    <dbReference type="CTD" id="2308"/>
    <dbReference type="GeneTree" id="ENSGT00940000161558"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001568">
        <property type="term" value="P:blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071455">
        <property type="term" value="P:cellular response to hyperoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071732">
        <property type="term" value="P:cellular response to nitric oxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of insulin secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032873">
        <property type="term" value="P:negative regulation of stress-activated MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:neuronal stem cell population maintenance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of autophagy"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000177">
        <property type="term" value="P:regulation of neural precursor cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070542">
        <property type="term" value="P:response to fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20060">
        <property type="entry name" value="FH_FOXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000032">
        <property type="entry name" value="Forkhead box protein O4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR047408">
        <property type="entry name" value="FH_FOXO1"/>
    </dbReference>
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        <property type="entry name" value="Fork_head_dom"/>
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    <dbReference type="InterPro" id="IPR032067">
        <property type="entry name" value="FOXO-TAD"/>
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    <dbReference type="InterPro" id="IPR032068">
        <property type="entry name" value="FOXO_KIX-bd"/>
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    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORKHEAD BOX PROTEIN O1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16676">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16675">
        <property type="entry name" value="FOXO_KIX_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="155"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="11">
        <location>
            <begin position="155"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001007738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027250747.1"/>
        </source>
    </evidence>
    <sequence length="650" mass="69596" checksum="17619D24D4837223" modified="2022-01-19" version="1">MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAPSGGAATNPDATANLASASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAASRGLCGDFQGPEAGCVHPAPPQQPPPTGPLSQPPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQPGQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAKMGSTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGNMMQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKPSYGGLNQYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNIRVLGQNVMMGPNSVMPAYGNQASHNKMMNPNSHTHPGHSQQTSSVNGRALPHVVNTMPNTSAMNRLTPMKTPLQVPLPHPMQMNTLGSYSSVSSCNGYGRMGVLHQEKLPSDLDGVLIEHLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LVF4</accession>
    <name>A0A8C2LVF4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">LOC100764104</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027281947.1">
        <property type="nucleotide sequence ID" value="XM_027426146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LVF4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012917.1">
        <property type="protein sequence ID" value="ENSCGRP00001008772.1"/>
        <property type="gene ID" value="ENSCGRG00001010987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764104"/>
    <dbReference type="KEGG" id="cge:100764104"/>
    <dbReference type="GeneTree" id="ENSGT00940000163303"/>
    <dbReference type="OrthoDB" id="6145535at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15233">
        <property type="entry name" value="7tmA_OR3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000010">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 12 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027281947.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34014" checksum="8A9F3FFC36782F07" modified="2022-01-19" version="1">MDLGASGNDSCVTTFVILGLTETPAVRPILFAIFLLAYVATIGGNFSILAAILIEPKLHTPMYFFLGNLSVLDVGCITVTVPVMLKHFLSNDRHILYGACLSQLFFFHLLAGTDCFLLTVMAYDRYLAICHPLTYSTHMSWRIQKASVCLSCLFSFSNALTQTVALSTLKFCGPNIINHFYCDLPQLFQLSCSSIQLNEQLLFVAAAFMGVVPLVLITVSYGHVAAAVLRIRSAEGRKKAFSTCSSHLTVVGIFYGTGVFSYMRLGSVEASDKDKGIGILNTVISPMLNPLIYSLRNPDVQGALRKVLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M090</accession>
    <name>A0A8C2M090_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline rich 9</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Proline-rich protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">Prr9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <reference evidence="1" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003511337.1">
        <property type="nucleotide sequence ID" value="XM_003511289.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248670.1">
        <property type="nucleotide sequence ID" value="XM_027392869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M090"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015231.1">
        <property type="protein sequence ID" value="ENSCGRP00001011002.1"/>
        <property type="gene ID" value="ENSCGRG00001012763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771146"/>
    <dbReference type="KEGG" id="cge:100771146"/>
    <dbReference type="CTD" id="574414"/>
    <dbReference type="GeneTree" id="ENSGT00700000104637"/>
    <dbReference type="OMA" id="SFNEQQC"/>
    <dbReference type="OrthoDB" id="9835460at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052888">
        <property type="entry name" value="PRR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48427">
        <property type="entry name" value="PROLINE-RICH PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48427:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027248670.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12756" checksum="13F8BE0E89AC7974" modified="2022-01-19" version="1">MSFSDQQCKQPCVPPPCLQKTQEKCQTQAEEVCVPSCQDPCQDKGPLQAQGICDPQCQEINQGNCPQQGQDPCLPPSQDQCLPQCVEPCQELAQTKCVEEFPQKVQEKCSSQGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M102</accession>
    <name>A0A8C2M102_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Afadin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Afadin adherens junction formation factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein Af-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Afdn</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Interacts with F-actin, nectin and NECTIN3. Essential for the association of nectin and E-cadherin. Isoform 2/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1, RIT2, NRXN1 and BCR. Interacts with ADAM10; the interaction locks ADAM10 at adherens junctions following ADAM10 recruitment to adherens junctions by TSPAN33.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027256954.1">
        <property type="nucleotide sequence ID" value="XM_027401153.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001015912.1">
        <property type="protein sequence ID" value="ENSCGRP00001011680.1"/>
        <property type="gene ID" value="ENSCGRG00001013153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751158"/>
    <dbReference type="KEGG" id="cge:100751158"/>
    <dbReference type="CTD" id="4301"/>
    <dbReference type="OrthoDB" id="6260541at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034330">
        <property type="term" value="P:cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22711">
        <property type="entry name" value="FHA_AFDN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15471">
        <property type="entry name" value="Myo5p-like_CBD_afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06789">
        <property type="entry name" value="PDZ_AFDN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01782">
        <property type="entry name" value="RA1_Afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01781">
        <property type="entry name" value="RA2_Afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000032">
        <property type="entry name" value="Afadin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000033">
        <property type="entry name" value="afadin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000006">
        <property type="entry name" value="Afadin, adherens junction formation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000025">
        <property type="entry name" value="Afadin, adherens junction formation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037977">
        <property type="entry name" value="CBD_Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="39"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="247"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="16">
        <location>
            <begin position="654"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="14">
        <location>
            <begin position="1000"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="197"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1100"/>
            <end position="1216"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1228"/>
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    </feature>
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            <begin position="1301"/>
            <end position="1519"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1560"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1726"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="1106"/>
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    </feature>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
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        </location>
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        <location>
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        </location>
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        </location>
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        <location>
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        <location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058472"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064935"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073709"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083790"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00084037"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011680.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027256954.1"/>
        </source>
    </evidence>
    <sequence length="1814" mass="205574" checksum="22784A2A836A4733" modified="2022-01-19" version="1">MSAGGREEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPAKKAQSNGPEKQDKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKEESPSQGDDGENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDSADFAVAESLEKYGLEKESPKDYCIARVMLPPGSQHSDERGAKEVILDDDECPLQIFREWPSDKGILVFQLKRRPPDYIPKKMKKHVEGKPMKGKDRVDGSGYGSALPPEKLPYLVELSPDGSDSRDKPKLYRLQLSVTEVGTEKFDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVDGQRISETTMLQSGMKVQFGTSHVFKFVDPVQDHVLSKRSVDGGLMVKGPRHKPGAIQETTFDLGGDIHSGTALPASRSTTRLDSDRVSSASSTAERGMVKPMIRLDQDQDYRRRESRTQDGTGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSSQHRPDISPTERTHKAIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYVPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVAVAENTADELARSDGRDVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLMRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSAQNGSPESPQLPWTEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSPYASGTAAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTESNHSSIAIQRVTRSQEELREEKVYQLERHRVEAGMDRKCDSDMWINQSSSVDSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAVLPTPVAVSQPIRTDLPPPPPPPPIHYTSDFDGIPVDLPLPPPPANQVGPQSAQVAAAERKKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPASFSPLATQAKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITISKEELSSGDSLSPDPWKRDAREKLEKQQQMHIVDMLSKEIQELQNKVDRTAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRVRQEEDRRHQEEERVKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEEPGLSRPPLPRDYEPPSPSPAPSAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYDDEEEEDCGSAGPHSYTGSAGTASGAHDAPRDPREKHTRSQDADFPGSSGAPENLTFKERQRLFSQGQDVSDKVKASRKLTELENELNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M210</accession>
    <name>A0A8C2M210_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch-like protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 25 26" type="primary">Klhl22</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="25 26">17A/GY</strain>
            <tissue evidence="25 26">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Interacts with PLK1. Interacts with DEPDC5 (via DEP domain); the interaction depends on amino acid availability. Interacts with YWHAE; required for the nuclear localization of KLHL22 upon amino acid starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003502510.1">
        <property type="nucleotide sequence ID" value="XM_003502462.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007641267.1">
        <property type="nucleotide sequence ID" value="XM_007643077.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268963.1">
        <property type="nucleotide sequence ID" value="XM_027413162.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268964.1">
        <property type="nucleotide sequence ID" value="XM_027413163.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M210"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016006.1">
        <property type="protein sequence ID" value="ENSCGRP00001011773.1"/>
        <property type="gene ID" value="ENSCGRG00001013341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752906"/>
    <dbReference type="KEGG" id="cge:100752906"/>
    <dbReference type="CTD" id="84861"/>
    <dbReference type="GeneTree" id="ENSGT00940000159598"/>
    <dbReference type="OMA" id="ACYKPST"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005827">
        <property type="term" value="C:polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18461">
        <property type="entry name" value="BACK_KLHL22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000018">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000040">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000083">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030575">
        <property type="entry name" value="KLHL22_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF5">
        <property type="entry name" value="KELCH-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="21">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_027268963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027268964.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="71873" checksum="FED0F062A633D0C8" modified="2022-01-19" version="1">MAEEQDFFQLCKLPTQPSHSHYVSNTYRSTQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAEVFDLNRLTQQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYYYSLEQVQADQISLNEPPKLLETVRFPLMEVDVLQQLHDKLDPSPLRDTVASALMYHQNESLQPSLQGPQTELRSDFQCVVGFGGIHSTPSTILSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLCVCVVGKYIYAVAGRDYHNDLSAVERYDPATNSWDYVAPLKKEVYAHAGTTLQGKMYITCGRRGEDYLKETHCYDPESNTWHTLADGPVRRAWHGMAALLDKLFVIGGSNNDAGYRRDVHQVACYSCTSRQWSMVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRMGYVHIYDIEKDCWEEGPQLNNSISGLAACVLTLPRSLLCEPPRGTPNRSQADADVASEVMSVSDWEEFDNSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M5F1</accession>
    <name>A0A8C2M5F1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IQ motif and ankyrin repeat containing 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">IQ motif and ankyrin repeat domain-containing protein LOC642574 homolog isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">Iqank1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_035296576.1">
        <property type="nucleotide sequence ID" value="XM_035440685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M5F1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018814.1">
        <property type="protein sequence ID" value="ENSCGRP00001014577.1"/>
        <property type="gene ID" value="ENSCGRG00001015411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113834518"/>
    <dbReference type="KEGG" id="cge:113834518"/>
    <dbReference type="CTD" id="642574"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001014577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035296576.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="64285" checksum="1B1F134E11F977E1" modified="2022-01-19" version="1">MSSKKGGPKAAPGKRQAPLPGSKLRAAAGKPKDHQLQTKTGQPAKESYSENPEVPAAPTAQDKAATIIQCAFRQHLARKELARRGQERQKYLDEMEKLQREAYLALVRREQEAARRQREQEEAAERARREELQRRHRLLEAAFDGDLGEIRAVLKEVDQLLTREGVGQDEAGKARRLQRRVAMVECEDSHGNTPLSEAAAGGQPLAIQLLAELGASPNSKGAFGRTPLYRAAFGGHLEAVEVLLKLGADPRVYADDGSTPEQVASLAAVASVLQSWDLSLTEAMLQNMEAEQQRRAQEAQKHKEIEAKRINLKVEQLAKEQQRCHKELQQAYCELNRRITEHDKCERKRMGKTELTLQAIKDAEAQVELLRLEAQKAEETLAMARLELREQTQEEEELAAPGLRCRVTELHDVLMKDVGDRIRADGRWPLVIDPSGQAATFLRYQDTNYVDTVNPEHLRPETIRQALIGALRYGKPLVFDLREVNLFPTVQQQLEAVQPGLAQALLSRGLLAQEGYLSLLRPTDGPEYDPSQFQEARLEHFRLFFVTRVQWPPDDQLQILLPVRVQLSGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M5L0</accession>
    <name>A0A8C2M5L0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Probable ribonuclease ZC3H12C isoform X3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Zinc finger CCCH type containing 12C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Zc3h12c</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027270905.1">
        <property type="nucleotide sequence ID" value="XM_027415104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M5L0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016457.1">
        <property type="protein sequence ID" value="ENSCGRP00001012224.1"/>
        <property type="gene ID" value="ENSCGRG00001013672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753033"/>
    <dbReference type="CTD" id="85463"/>
    <dbReference type="GeneTree" id="ENSGT00940000158397"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18729">
        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF36">
        <property type="entry name" value="RIBONUCLEASE ZC3H12C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027270905.1"/>
        </source>
    </evidence>
    <sequence length="903" mass="101242" checksum="FDFE3EAD3C7EB97A" modified="2022-01-19" version="1">MEAGPGAAEGNGPTAVILPLGPSRAGGEYGVLCIQEYRKSSKVESSVRNSFMGLKDHLGHDLGHLYMESTDPQISAAVPWPMVEKPTMDTVNSGKEEKEVSEESVSSGDSEESTNSDHESGQLNSLSVEPCLLTKTHRQLCRSPCLEPHLLKHSDILQDFKPDVSQTPSKEVKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTINSVMRETSSLESQRSESPMQDIVTDDGENLRPVVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAAKTTNEGGLVKSNSVPCSTKVDSTSDVKRGAPKRQSDPSIRTHVYQDIEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSISGPRSPERRFSLDTDYRVNSVASDCSSEGSMSCGSSDSYVGYNDRSYVSSPDPQLEDNMKCQHMHPHSRLNSQPFLQNFHDPVTRVQSYSHEEPKFHHKPPLPHLAMHLQHPAVGARSSCPGDYPSPPSSAHSKAPHLGRSLVATRIDSISDSRLYDSSPSRQRKPYTRQEGLGSWDRPSYGMDAYGYRQTYSLPDNSTPPCYEPVTFQSLPEQQEPTWRIPYCGMPQDPPRYQDNREKIYINLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MQD4</accession>
    <name>A0A8C2MQD4_CRIGR</name>
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        <submittedName>
            <fullName evidence="2">RIKEN cDNA A830018L16 gene</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein C8orf34 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">CUNH8orf34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027254643.1">
        <property type="nucleotide sequence ID" value="XM_027398842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MQD4"/>
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        <property type="protein sequence ID" value="ENSCGRP00001020648.1"/>
        <property type="gene ID" value="ENSCGRG00001019731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766125"/>
    <dbReference type="KEGG" id="cge:100766125"/>
    <dbReference type="CTD" id="103174780"/>
    <dbReference type="GeneTree" id="ENSGT00390000005870"/>
    <dbReference type="OrthoDB" id="9945857at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22980">
        <property type="entry name" value="DD_VEST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040687">
        <property type="entry name" value="DUF5586"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32000:SF3">
        <property type="entry name" value="RIKEN CDNA A830018L16 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32000">
        <property type="entry name" value="SIMILAR TO HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17824">
        <property type="entry name" value="DUF5586"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
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        <location>
            <begin position="345"/>
            <end position="397"/>
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        <location>
            <begin position="72"/>
            <end position="85"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027254643.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51567" checksum="D503A19D8A995D99" modified="2022-01-19" version="1">MASRQQTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQGNRGQLQRTLSGSAALWAESETSEPKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWSWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETMAFNSSLLRPRVIGEWIGRAENDADPLAAEMLQPPVPRSKNDPWESEESCSSPAGSLKMEPKTKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSAIEDDIDNEDDAMELLEDLDDLRMEGVTTLVPSGSKFNQGRPTHPAEPQAKVTLNICSRCARLQGDNLMERAEDTLQPFHSPEERIPDSLDSLPGTEETLMEEGEDLEKTSKLTEHGEDSSGGHSLKSYIEEDESLKQLQVVHQPWLLPSDTESEGVEAEQEKRTADLLCVPCSSCPTLIYSGLSVKQAKDISSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MRG1</accession>
    <name>A0A8C2MRG1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Single Ig IL-1-related receptor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13 14 15" type="primary">Sigirr</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14 15">17A/GY</strain>
            <tissue evidence="13 14 15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027240584.1">
        <property type="nucleotide sequence ID" value="XM_027384783.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027240585.1">
        <property type="nucleotide sequence ID" value="XM_027384784.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027240586.1">
        <property type="nucleotide sequence ID" value="XM_027384785.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264816.1">
        <property type="nucleotide sequence ID" value="XM_027409015.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264817.1">
        <property type="nucleotide sequence ID" value="XM_027409016.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264818.1">
        <property type="nucleotide sequence ID" value="XM_027409017.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MRG1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025350.1">
        <property type="protein sequence ID" value="ENSCGRP00001021106.1"/>
        <property type="gene ID" value="ENSCGRG00001020035.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758695"/>
    <dbReference type="KEGG" id="cge:100758695"/>
    <dbReference type="CTD" id="59307"/>
    <dbReference type="GeneTree" id="ENSGT01090000259985"/>
    <dbReference type="OMA" id="WCTNNFR"/>
    <dbReference type="OrthoDB" id="6075577at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032682">
        <property type="term" value="P:negative regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000660">
        <property type="term" value="P:negative regulation of interleukin-1-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045751">
        <property type="term" value="P:negative regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000011">
        <property type="entry name" value="single Ig IL-1-related receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF19">
        <property type="entry name" value="SINGLE IG IL-1-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 14 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="8">
        <location>
            <begin position="162"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027264816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027264817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027264818.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45652" checksum="8774F0AFE58E87EE" modified="2022-01-19" version="1">MAGVCDRALHFLSPPEDQALGPALGSAVALNCTAWVVSRPQCPQPSVQWLKDGLPLGNGSHFSLHQDFWVSANFSRVVSSVLVLNLTNAEDYGSFTCSVWNVSSHSFTLWKAGPAGHVVAVLASLLVLLVLLLVALLYVKCRLNVLLWYQDAYGEVEMNDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLGRAWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLLLWKPGSVAPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRAMELDPDPEGDLGVRGPVFGEPPTPLHSSRVSEGEGHGSEMDVSDLGSRNYSARTDFYCLVSEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MS33</accession>
    <name>A0A8C2MS33_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sestrin 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Sestrin-3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Sesn3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a hydroperoxide + L-cysteinyl-[protein] = S-hydroxy-L-cysteinyl-[protein] + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:67124"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:17193"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67125"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027270933.1">
        <property type="nucleotide sequence ID" value="XM_027415132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MS33"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027210.1">
        <property type="protein sequence ID" value="ENSCGRP00001022965.1"/>
        <property type="gene ID" value="ENSCGRG00001021337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764047"/>
    <dbReference type="KEGG" id="cge:100764047"/>
    <dbReference type="CTD" id="143686"/>
    <dbReference type="GeneTree" id="ENSGT00950000183168"/>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046626">
        <property type="term" value="P:regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1290.10:FF:000001">
        <property type="entry name" value="Sestrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF4">
        <property type="entry name" value="SESTRIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027270933.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56997" checksum="2D65283D40FF3411" modified="2022-01-19" version="1">MNRGGSSAAASANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMGLHTQYLESFLRSQFYMLRMDGPLPLPDRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLRNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPEREPGISNGFRLISVNSFCVCDLANDNSIENTSLAGSNFGIVDSLGELEALMERMKRLQEDRGDEETTREEMTTRFEKEKKESLFVVPGESFHSFPHSDFEDDTIITADVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYSLTYNTMATHEDVDTTTLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFTHSEKVHVNLLLMEARMQAELLYALRAITRHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MT34</accession>
    <name>A0A8C2MT34_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="9">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Etfa</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interaction with ETFRF1 promotes dissociation of the bound FAD and loss of electron transfer activity. Interacts with TASOR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003497958.1">
        <property type="nucleotide sequence ID" value="XM_003497910.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270838.1">
        <property type="nucleotide sequence ID" value="XM_027415037.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MT34"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027691.1">
        <property type="protein sequence ID" value="ENSCGRP00001023445.1"/>
        <property type="gene ID" value="ENSCGRG00001021669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100758144"/>
    <dbReference type="KEGG" id="cge:100758144"/>
    <dbReference type="CTD" id="2108"/>
    <dbReference type="GeneTree" id="ENSGT00390000013422"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="279"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027270838.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="35090" checksum="6A40CA91B1B6D10D" modified="2022-01-19" version="1">MFRAAAPGQLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAAGRLGGEVSCLVAGTKCDKVVQDLCKVAGVAKVLVAQHDAYKGLLPEELTPLILETQKQFNYTHICAGASAFGKNLLPRVAAKLDVAPISDIIEIKSPDTFVRTIYAGNALCTVKCDERVKVFSVRGTSFEAAATSGGSASSEKAPSSSPVGISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLFKVVPEMTEILKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MW51</accession>
    <name>A0A8C2MW51_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UBX domain-containing protein 2B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">NSFL1 cofactor p37</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">p97 cofactor p37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23" type="primary">Ubxn2b</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with VCP. Does not bind ubiquitin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NSFL1C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027254700.1">
        <property type="nucleotide sequence ID" value="XM_027398899.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311453.1">
        <property type="nucleotide sequence ID" value="XM_035455562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MW51"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029006.1">
        <property type="protein sequence ID" value="ENSCGRP00001024760.1"/>
        <property type="gene ID" value="ENSCGRG00001022571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100755666"/>
    <dbReference type="KEGG" id="cge:100755666"/>
    <dbReference type="CTD" id="137886"/>
    <dbReference type="GeneTree" id="ENSGT00520000055567"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904780">
        <property type="term" value="P:negative regulation of protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046604">
        <property type="term" value="P:positive regulation of mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000001">
        <property type="entry name" value="NSFL1 (P97) cofactor (P47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000135">
        <property type="entry name" value="UBX domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SEP_domain"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF14">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
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    </dbReference>
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        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="18">
        <location>
            <begin position="255"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00038241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040562"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041414"/>
        </source>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042371"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059433"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001024760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027254700.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37268" checksum="69C05247637F7686" modified="2022-01-19" version="1">MAEGGRADPEEQERGSSRPRPPSARDLQLALAGLYEDEVKCKSSKPDKSTAAAFKSPRTLPHRLCSGEQEYGGLHIVQPPTGKIVNELFKEAREHGAVPLNEATRSSSDDKPKSFTGGGYRLGSSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDDGELRPYNDPTNAQFLESVKRGEIPLELQRLVHGSQVSLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNVLNAAVLIDDSVPTTKVQIRLADGSRLIQRFNSTHRILDVRDFIIQSRPEFATTDFILVTSFPSKELTDENLTLQEADILNTVILQQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MYN5</accession>
    <name>A0A8C2MYN5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Jupiter microtubule associated homolog 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Jpt2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
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        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JUPITER family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007640366.1">
        <property type="nucleotide sequence ID" value="XM_007642176.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027425014.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MYN5"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030192.1">
        <property type="protein sequence ID" value="ENSCGRP00001025946.1"/>
        <property type="gene ID" value="ENSCGRG00001023398.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
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        <property type="term" value="P:endocytosis involved in viral entry into host cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="GEO05313P1"/>
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    </dbReference>
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        <property type="entry name" value="JUPITER MICROTUBULE ASSOCIATED HOMOLOG 2"/>
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    </dbReference>
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            <end position="125"/>
        </location>
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        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027280815.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="19885" checksum="8E9ACAC793EC2A62" modified="2022-01-19" version="1">MFQGADGQAGGSGSRAMKPPGGESSNLFGTPEEGIPSSKPNRMASNIFGPTEEPKNIPKRTNPPGGKGSGIFDESTPVQTRQRLNPPGGKTSDIFGSPVTATAPLAHPNKPKDHVLLCEGEDSKSDLNATTNSTPKGEQSEKGSSKEADHAKIPEPTPTVDSHEPRLGPRPRSHNKVLNPPGGKSSISFY</sequence>
</entry>
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    <accession>A0A8C2MYY7</accession>
    <name>A0A8C2MYY7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12 15">Transmembrane protein 214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Tmem214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM214 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003497081.1">
        <property type="nucleotide sequence ID" value="XM_003497033.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027280313.1">
        <property type="nucleotide sequence ID" value="XM_027424512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MYY7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030014.1">
        <property type="protein sequence ID" value="ENSCGRP00001025768.1"/>
        <property type="gene ID" value="ENSCGRG00001023263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100761817"/>
    <dbReference type="KEGG" id="cge:100761817"/>
    <dbReference type="CTD" id="54867"/>
    <dbReference type="OMA" id="NGSAGKW"/>
    <dbReference type="OrthoDB" id="10022292at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027280313.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="76415" checksum="18577344E9BCC503" modified="2022-01-19" version="1">MAARAAGSGGWEVVKKGRRPGASGGGRGVGGSDRRALGEANGVWKYDLSSPIQTTSTLYERGFEKIMKRQNKEQVPPPVVESKKPGNKKQPKKVTAVTSQNQKQGLFRSLEDALKALDVAALKKELDKSQSVFTGNPSVWLKDLASYLNYKLQTPRIEPTLSQYPHDYPYSLVSQELRGIIQGLLTKAAGSVELFFDHCLFTMLQELDKTPGESLHGYRICIQAILQDRPKIVTSNLGKFLELLRSHQSRPAKCLTIMWALGQAGFANLTEGLKVWLGIMLPVLGIKSLSPFAIAYLDRLLLMHPNLTKGFGMIGPKDFFPLLDFAYMPNNSLTPSLQEQLCQLFPRLKVLAFGAKPESTLHTYFPSFLSRATPSCPAEMKRELLGSLTQCLTVDPLSTSVWRQLYPKHLSQSSLLLEHLLKSWERIPKKARKSLQETIQSFKLANQELLKKGSGGNEHVVTCDAACKGLLQQARGPRPPWARLLLLLLVFAVGFLCHDFRSHGSFQASLTGWLLRSSGFLPVGQHLCAKLYSCSIQSYSWLQETLPAYGSHLLAVIQPSLQLAWTHTDATVSFLSAHCASYLAYFGDSLAGFLQRVQLPEALHQLLHSLKDLLLLFYHSVLLPLWHLLLAALARAQEHCHQACRGEVTWDCIKTQFGEAARWTWLCLQDVTVAFLDWALAMISQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N163</accession>
    <name>A0A8C2N163_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH2 domain-containing adapter protein F isoform X3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Src homology 2 domain containing F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Shf</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_003504830.3">
        <property type="nucleotide sequence ID" value="XM_003504782.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277792.1">
        <property type="nucleotide sequence ID" value="XM_027421991.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N163"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031227.1">
        <property type="protein sequence ID" value="ENSCGRP00001026980.1"/>
        <property type="gene ID" value="ENSCGRG00001024124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772067"/>
    <dbReference type="KEGG" id="cge:100772067"/>
    <dbReference type="CTD" id="90525"/>
    <dbReference type="OrthoDB" id="5914531at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10392">
        <property type="entry name" value="SH2_SHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000021">
        <property type="entry name" value="Putative SH2 domain-containing adapter protein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035044">
        <property type="entry name" value="SHF_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF28">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING ADAPTER PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="340"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027277792.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="46788" checksum="1E19BDCE089F9DB9" modified="2022-01-19" version="1">MLLSGAPPPGSGPGPRAQGSAGGGPGGSRRGAGGAGAGPGGGGSGGVAKWLREHLGFRGGGGGGGAKPAPPEPDYRPPAPCPAAPPAPPPDILAAYRLQRDRDFEDPYSGGSSVSAALSTPAAPGPTPPPRHGSPPHRLIRVETPGPPAPPPEERISGPHASSDRLAILEDYADPFDVQETAEGSGGTSMAPEKVPENDGYMEPYEAQKMMAEIRGSKETAAQPLPLYDTPYEPEDEGASPEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAAQFEGSEKNCLSPGREEKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N3N0</accession>
    <name>A0A8C2N3N0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Mtch2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins. Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis. Regulates the quiescence/cycling of hematopoietic stem cells (HSCs). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with p15BID.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027278407.1">
        <property type="nucleotide sequence ID" value="XM_027422606.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N3N0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032192.1">
        <property type="protein sequence ID" value="ENSCGRP00001027944.1"/>
        <property type="gene ID" value="ENSCGRG00001024807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764518"/>
    <dbReference type="KEGG" id="cge:100764518"/>
    <dbReference type="CTD" id="23788"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071478">
        <property type="term" value="P:cellular response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090152">
        <property type="term" value="P:establishment of protein localization to mitochondrial membrane involved in mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061484">
        <property type="term" value="P:hematopoietic stem cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035701">
        <property type="term" value="P:hematopoietic stem cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097284">
        <property type="term" value="P:hepatocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010917">
        <property type="term" value="P:negative regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902231">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000738">
        <property type="term" value="P:positive regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010635">
        <property type="term" value="P:regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902108">
        <property type="term" value="P:regulation of mitochondrial membrane permeability involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000035">
        <property type="entry name" value="Mitochondrial carrier homolog 2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF20">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027278407.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33368" checksum="D81BE8943D3281E8" modified="2022-01-19" version="1">MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVYQLPGLFCYAQHIASIDGKRGLFTGLTPRLCSGVLGTVVHGKVLQHYQECDKPEELVSGNVQKENSSSFDRVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIMTIYREEGIVGFFAGLIPRLLGDIISLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGLPPYSPIYTSWIDCWCILQKAGNMSRGNSLFFRKVPCGKTYCCDLSMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N6F2</accession>
    <name>A0A8C2N6F2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-defensin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Defb129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Has antibacterial activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the beta-defensin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003502353.1">
        <property type="nucleotide sequence ID" value="XM_003502305.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278515.1">
        <property type="nucleotide sequence ID" value="XM_027422714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N6F2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032151.1">
        <property type="protein sequence ID" value="ENSCGRP00001027903.1"/>
        <property type="gene ID" value="ENSCGRG00001024777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750561"/>
    <dbReference type="KEGG" id="cge:100750561"/>
    <dbReference type="CTD" id="140881"/>
    <dbReference type="GeneTree" id="ENSGT00390000008616"/>
    <dbReference type="OMA" id="RRCLMGF"/>
    <dbReference type="OrthoDB" id="9607806at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025933">
        <property type="entry name" value="Beta_defensin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13841">
        <property type="entry name" value="Defensin_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0211">Defensin</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044520799" description="Beta-defensin" evidence="6">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-defensin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU231113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027278515.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18336" checksum="BB7A24A17042C1F0" modified="2022-01-19" version="1">MKLLFPLIASLMLQYQVKPAFVGMKKCILGFGKCKDSCLAKEIEVQNCKSKKCCIGPKVTELIKSYLRHEIPHIPDKDIVEMLKNEKNFREEMQRKHTLAALFQPQDASPSHGINSAIVPNTSPVKFVTSRTRRHGLDGTVSTKRHMKPIRSSASAAPQPGPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QBI1</accession>
    <name>A0A8C2QBI1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein TMEM103</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">Elp6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003504296.1">
        <property type="nucleotide sequence ID" value="XM_003504248.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270468.1">
        <property type="nucleotide sequence ID" value="XM_027414667.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QBI1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000041.1">
        <property type="protein sequence ID" value="ENSCGRP00001000017.1"/>
        <property type="gene ID" value="ENSCGRG00001000041.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764169"/>
    <dbReference type="KEGG" id="cge:100764169"/>
    <dbReference type="CTD" id="54859"/>
    <dbReference type="GeneTree" id="ENSGT00390000011734"/>
    <dbReference type="OMA" id="MFTELNS"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048877">
        <property type="term" value="P:homeostasis of number of retina cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141084">
        <property type="term" value="P:inflammasome-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046530">
        <property type="term" value="P:photoreceptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001078">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027270468.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29555" checksum="C12519A27F7B3BFA" modified="2022-01-19" version="1">MFPELNNLLGTTPDGTEQGKLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALVQSFSHYNIVAQKLGVSLTAAREQGQLVFLEGLKSSVDIFFHAQEEPHPLQFLREASAGNLQSLYQFVRDSLKPVDSGETPWKFPVLLVDNLSVLLSLGLEAVAVLDFMQYCRATVCCELKGNVVALVHDNRDAEDKENGILLNGLSHQSHLVLRAEGLATGFCKDVHGQLRILWRRLQPTARRDQSLTYQYKIQDKNVSFFAKGMSPAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QI70</accession>
    <name>A0A8C2QI70_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">LOC100752163</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027242287.1">
        <property type="nucleotide sequence ID" value="XM_027386486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QI70"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017760.1">
        <property type="protein sequence ID" value="ENSCGRP00001013523.1"/>
        <property type="gene ID" value="ENSCGRG00001014650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752163"/>
    <dbReference type="KEGG" id="cge:100752163"/>
    <dbReference type="GeneTree" id="ENSGT00940000163164"/>
    <dbReference type="OrthoDB" id="9445499at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15913">
        <property type="entry name" value="7tmA_OR11G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050939">
        <property type="entry name" value="Olfactory_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242:SF183">
        <property type="entry name" value="OLFACTORY RECEPTOR 11G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="45"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027242287.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36223" checksum="E21ED988DABDB25C" modified="2022-01-19" version="1">MKTLSNPTNSSTITGFILLGFPCPREGQILLFMFFFIVYLLTLMGNASIICAVRWDQKLHTPMYLLLANFSFLEIWYVTSTVPNMLANFLSDTKVISFSGCFLQFYFFFSLGSTECFFLAVMAFDRYLAICRPLHYSALMTGRLCNILVISCWVLGFLWFPVPIIIISQMSFCGSRIIDHFLCDPGPLLALTCKKDLLIELVFSILSPLPLIIPFLFIMGSYALVLIAVLKVPSASGKRKAFSTCGSHLAVVALFYGSVLVMYGSPTSEHEAGMQKLVTLFYSVLTPFLNPVIYSLRNKHMKTALKKILGEIKTWSSKKTLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7EXD5</accession>
    <name>A0A9J7EXD5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Polr3a</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="RefSeq" id="XP_027244867.1">
        <property type="nucleotide sequence ID" value="XM_027389066.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100753811"/>
    <dbReference type="KEGG" id="cge:100753811"/>
    <dbReference type="CTD" id="11128"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 14 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="248"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027244867.1"/>
        </source>
    </evidence>
    <sequence length="1390" mass="155686" checksum="783A76D22DDB005B" modified="2023-06-28" version="1">MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNNHAPLLYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQEEKQQFLDFLKRPGLTYLQKRGLKKKISDKCRKKSTCHYCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPVVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVRNGPDVHPGANFIQQRHMQMKRFLKYGNREKMAQELKFGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSIILRPSDDSPVRANLRTKGKQYCGKGEDLCVNDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVYPCQSEPALSKNELTLTTEAIMKKNEFLCCQDSFLQEIKTFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQIEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQGIPEVSRAVIHIDEQSGKEKFKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKANRDPKPPRRPLIFDTNEFHIPLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F2J0</accession>
    <name>A0A9J7F2J0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CD5 antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cd5l</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003502975.1">
        <property type="nucleotide sequence ID" value="XM_003502927.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248820.1">
        <property type="nucleotide sequence ID" value="XM_027393019.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F2J0"/>
    <dbReference type="GeneID" id="100759713"/>
    <dbReference type="KEGG" id="cge:100759713"/>
    <dbReference type="CTD" id="922"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000010">
        <property type="entry name" value="T-cell differentiation antigen CD6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF487">
        <property type="entry name" value="SOLUBLE SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039924022" evidence="6">
        <location>
            <begin position="22"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="242"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="162"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027248820.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="38828" checksum="EAD3692240CA6793" modified="2023-06-28" version="1">MAPLFNLMLAISAIFIGSCLSESPPKVRLVGGPHRCEGRVEVELNGQWGTVCDDGWDLKDVAVVCRELNCGAARKTPRGAKYKPAAPKEQKVLIQDVNCNGMEGTLSECEQNEDVFNCPHEEDAGVQCEDPFTPENVRLVDGPGHCRGRVEVLHQAQWSSVCKAGWNLRASKVACRQLGCGRALLTHRCCNKMAQGKGPIWKGQMSCSGHEANLRDCPFKPLENNCTHSEDTWMECEDPFELRLVGGDNPCSGRLEVLHMGTWGSVCDDGWGEKEDQVVCKQLSCGKPLFPSFKARKSYGPGAGRIWLDDVVCSGEEQSLESCRHRLWGYHDCTHKEDVAVICSESTPDFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F6K9</accession>
    <name>A0A9J7F6K9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Disco-interacting protein 2 homolog B isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Dip2b</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027252370.1">
        <property type="nucleotide sequence ID" value="XM_027396569.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100750591"/>
    <dbReference type="KEGG" id="cge:100750591"/>
    <dbReference type="CTD" id="57609"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000003">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000004">
        <property type="entry name" value="Disco interacting protein 2 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000002">
        <property type="entry name" value="Disco interacting protein 2 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF38">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027252370.1"/>
        </source>
    </evidence>
    <sequence length="1574" mass="171046" checksum="809BB940E6D515FA" modified="2023-06-28" version="1">MAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPYSPQTQETDSTGQKDKNQTPAPTAAQTSAPSKYHRTRSGGARDERYRSDIHTEAVQAALAKHKEQKMALPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAALSAALQQSLQNAESWINRSIQGSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENVSAPPDVTATTSSSSSSLRPANIDLPPSGIVKGMHKGSNRSSLMDTADGVPVNSRVSTKIQQLLSTLKRPKRPPLKEFFVDDSEEIVEGIPQPDPNQPKPEGRQMTPVKGEPLGVICNWPPALESALQRWGSTQAKCPCLTGLDVSGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEICLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPHISPAGTEPAYIEYKTSKEGSVMGVTVSRLAMLSHCQALSQACNYSEGEAVVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGLPQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVASSGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILTTQTLMRLLKSREAAAAVDVKTWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSILIPPLELENNLFLWLATVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCIRTCVVVAEERPRITLQQSFSKLFKDIGLSPRAVSTTFGARVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRVHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLADQLDPIYVAYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F870</accession>
    <name>A0A9J7F870_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Transmembrane protein 232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">Tmem232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4">17A/GY</strain>
            <tissue evidence="3 4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_003499417.1">
        <property type="nucleotide sequence ID" value="XM_003499369.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007638318.1">
        <property type="nucleotide sequence ID" value="XM_007640128.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027253558.1">
        <property type="nucleotide sequence ID" value="XM_027397757.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297061.1">
        <property type="nucleotide sequence ID" value="XM_035441170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F870"/>
    <dbReference type="GeneID" id="100757866"/>
    <dbReference type="KEGG" id="cge:100757866"/>
    <dbReference type="CTD" id="642987"/>
    <dbReference type="OMA" id="DHHWQEE"/>
    <dbReference type="OrthoDB" id="10016194at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031747">
        <property type="entry name" value="TMEM232"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28651">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28651:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15877">
        <property type="entry name" value="TMEM232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027253558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035297061.1"/>
        </source>
    </evidence>
    <sequence length="688" mass="79390" checksum="F08C0FFEAD648814" modified="2023-06-28" version="1">MPVDKSPSINKFGVISSTYYEELLKFNLESTNRKKNHKPKPSFSISKEFILKFNNTQNPSEQEELLEQARKLLARCKRKLGLKTLGSGKYVHLPSAWAEIIYLAQCKGEIQDEALNMLHASLDQVSFNSDQLPALFFLAESVLYRLCCDAFLKGFLYSVELKLVKIGYLIFLRLFVFFLHGHLESFKQHLLRLQPYLYALYFSEVSYHKYPNVFSNVQFILKVSEIICKKELHSETVVGNTGGIEGVFSDLEHMALDQGGYEVNQLLWHCVAAWSCVQNNSPQLNEVLEHLLFHKTKLQTKCWLDSVLALMVLGEAAKLNLACLKTLMGLVKDFILSIFSVDNQRESYEEYDLSWASDVIFIYTTIISEVCLYAATSYLRKTALIGFCDCPSLQKDALLMNKSEVQPELEGMSILSLLKYFSSKMSINCAKLIWVGYYGIVYNMVKMSWELQGDEEQDGLRNLIWKTLQNIKDYEQDPRIQIALTVAQAELNEQVDPFTRYSRKATPNLGEEVFSKYIGWRVSSTLSKLFFPSPNSCALSSKTSEISLQRKGTAKTQAFATKKDIHFVVKDHSSELDICMFPYPDFFTKADKKLAEIIDHHWQKDMEIRKQEEAEYEEQRQKEEEIKEKVRFQEIMKQRQKKLNKQTKPYEIPWLEKKDGPGKESGFRGQETKTLPKLRGRKASLELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FJS5</accession>
    <name>A0A9J7FJS5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Lrrc69</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027259347.1">
        <property type="nucleotide sequence ID" value="XM_027403546.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293962.1">
        <property type="nucleotide sequence ID" value="XM_027438161.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FJS5"/>
    <dbReference type="GeneID" id="100767187"/>
    <dbReference type="KEGG" id="cge:100767187"/>
    <dbReference type="CTD" id="100130742"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF13">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027259347.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40854" checksum="81CA39F7056136BE" modified="2023-06-28" version="1">MVAFSKIMTERLLIRALKGGSNTKIITLNGKKMTKMPSALERLPALKTLDLRNNLISKVCPELSTLTQLTLLNLGNNLLEEVPEELKYLTSLKKLHLFGNRICRIAPGVWDGLQKLILLNLNDNQLESLPQEVGRLRNLTYLSIDHNQLTMIPKELCSLENLLELHLNYNQLMCIPEEIKLLKNLQQLFLVRNNIEVLPQGLCQLEKLRLLDIAGNVIQIFPAGFQKLNLREFYCEGNPLFLKRPITTEQPKDIWTLREIAARFVLCLLEENNDLIMNAIEYYPEAKEKISKARKCALCRKPFLSEWLECVQFVSPSKNWKISRNLQLIPLRILLCSHECFRQRGRNVFGIAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FMQ4</accession>
    <name>A0A9J7FMQ4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100773838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263832.1">
        <property type="nucleotide sequence ID" value="XM_027408031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FMQ4"/>
    <dbReference type="GeneID" id="100773838"/>
    <dbReference type="KEGG" id="cge:100773838"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15222">
        <property type="entry name" value="7tmA_OR51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000002">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF84">
        <property type="entry name" value="OLFACTORY RECEPTOR 51Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="49"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027263832.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36526" checksum="D73DAD571E87D9B5" modified="2023-06-28" version="1">MLYPPSMSEITNTTHDPFYFILTGIPGFEAFHLWISIPFFCLYIISIMGNTTILTVIRTEPSLHQPMYFFLSMLALTDLGLTLTTLPTVMQLLWFNIQEISFEACFAQFFFLHGFSFMESSVLLAMSFDRYVAICRPLHYASILTNGVIGRIGLAIICRCVLAVLPSLFLLKRLPFCHSHLLSHSYCLHQDMIHLVCADIRINSWYGFALVLLIIVLDPLLIILSYALILKSILNTATWTERLRALNNCVSHMLAVLVLYVPMVGVSMTHRFAKHASPLVHVFMANIYLLAPPVMNPIIYSAKTKQIRQGITRLLLQRKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FMV7</accession>
    <name>A0A9J7FMV7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P)(+)--arginine ADP-ribosyltransferase</fullName>
            <ecNumber evidence="10">2.4.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mono(ADP-ribosyl)transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100750708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
            <dbReference type="EC" id="2.4.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Arg-specific ADP-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.31" evidence="10"/>
    <dbReference type="RefSeq" id="XP_027263300.1">
        <property type="nucleotide sequence ID" value="XM_027407499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750708"/>
    <dbReference type="KEGG" id="cge:100750708"/>
    <dbReference type="OrthoDB" id="423533at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.176.10:FF:000001">
        <property type="entry name" value="NAD(P)(+)--arginine ADP-ribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.176.10">
        <property type="entry name" value="Toxin ADP-ribosyltransferase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050999">
        <property type="entry name" value="ADP-ribosyltransferase_ARG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000768">
        <property type="entry name" value="ART"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339">
        <property type="entry name" value="ADP-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339:SF24">
        <property type="entry name" value="T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01129">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00970">
        <property type="entry name" value="RIBTRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01291">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51996">
        <property type="entry name" value="TR_MART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027263300.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="41947" checksum="713346A920E11AFE" modified="2023-06-28" version="1">MTKSAATQVHNQEFELGKPNNYPIYDLRECVKALVLCNYGLHDLQQQQDFGKGQTPSHKRSALVPDKSKLCAPSREASKVEGTQKNLRAAMSVAAEHNEIVSMQVPCMRLKVTSHAVTGQTESSNLDMAPDAFDDQYEGCVQEMEKKAPQLLEXGFNMNKDLKVEWEKAEKKWKEIKNKMTYPKGFSDYHGTAVVMYTGGIYKKFNIGFRDFKKDPSNFPYKAFHYYLTRALQLLNNNKCYTVYRGTNNKFHYSGTGSVRFGQFASSSFDKMVATKFSGASGTLFTIKTCLGVNITGFSYKPEQKVLIPGYEVFKAHKSPGSEKTMDNISLTSPKRGKSNFNCFYSSGTRDSPAFLLLVVLPGLLVQLLPLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FN40</accession>
    <name>A0A9J7FN40_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC100757005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027260818.1">
        <property type="nucleotide sequence ID" value="XM_027405017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FN40"/>
    <dbReference type="GeneID" id="100757005"/>
    <dbReference type="KEGG" id="cge:100757005"/>
    <dbReference type="OrthoDB" id="9598168at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027260818.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34564" checksum="4215E7E885E18F96" modified="2023-06-28" version="1">MSFMDAPNHTTVTEFILLGLTENSTLRVILFMIFLGIYAVTLVGNISIITLIRSCPQLHTPMYLFLSHLAFVDIGFSTSITPIMLTGFLGYGTVLSVAACETQFSIAVTFGTAECFLLAAMAYDRYVAICLPLLYSTHMSPRICFLLVGVSYVGGCVNSWTFTGCLLSLSFCGPNQIDHFFCDFPAVLKLSCSDISIIGIIPSISAGSIIVLTVFVIAVSYTYILITILKMRSTEGRHKAFSTCTSHLTAVTLYYGTITFIYVMPKSSYSTEQNKIVSVFYTVVIPMLNPLIYSLRNRDVKEALRKATIRIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FNP0</accession>
    <name>A0A9J7FNP0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Osbp</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer or homotrimer. Interacts (via FFAT motif) with VAPA. Interacts (via C-terminus) with RELCH (via the third HEAT repeat). Found in a complex composed of RELCH, OSBP1 and RAB11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027262438.2">
        <property type="nucleotide sequence ID" value="XM_027406637.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100760367"/>
    <dbReference type="KEGG" id="cge:100760367"/>
    <dbReference type="CTD" id="5007"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13284">
        <property type="entry name" value="PH_OSBP_ORP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000074">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="86"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="723"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027262438.2"/>
        </source>
    </evidence>
    <sequence length="805" mass="89207" checksum="FD77345D4518F679" modified="2023-06-28" version="1">MAATELRGVVGPXPAAIAAPGGGGAGPPAVGGGGGRGDAGPGSGVASASAAAAXAPWPGAGGVAAGGPGSAPPAAGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGSAGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCFKVQPASGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHVYRGEYWECKEKQDWGSCPDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G265</accession>
    <name>A0A9J7G265_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Signal peptide peptidase-like 3 isoform X5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Sppl3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027271833.1">
        <property type="nucleotide sequence ID" value="XM_027416032.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G265"/>
    <dbReference type="GeneID" id="100774388"/>
    <dbReference type="KEGG" id="cge:100774388"/>
    <dbReference type="CTD" id="121665"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF22">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027271833.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="54176" checksum="EA232D4A8954EEDD" modified="2023-06-28" version="1">MSPGRRRRARARRSRGPARTERGPELPFAPRALVLRAAAAAMLGLEPQRSAAAAAADEAERGARPAPGPRQRGPVGVPSEPECPSALRASLRAPGRALCRRPSEPRSPERGSTMAEQTYSWAYSLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKEKDSNSSSGSFNGNSTNNSIQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQYLTRPCSPQNKISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAFVRLPSLKVSCLLLSGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPSVGRDVPRLSLPGKLVFPSSTGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAPGPANISGRMQKVSYFHCTLIGYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G2H2</accession>
    <name>A0A9J7G2H2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CapZ-interacting protein isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Rcsd1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027272931.2">
        <property type="nucleotide sequence ID" value="XM_027417130.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G2H2"/>
    <dbReference type="GeneID" id="100771004"/>
    <dbReference type="KEGG" id="cge:100771004"/>
    <dbReference type="CTD" id="92241"/>
    <dbReference type="OrthoDB" id="9450049at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905394">
        <property type="term" value="F:retromer complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029341">
        <property type="entry name" value="FAM21/CAPZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF2">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15255">
        <property type="entry name" value="CAP-ZIP_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM21/CAPZIP" evidence="3">
        <location>
            <begin position="170"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027272931.2"/>
        </source>
    </evidence>
    <sequence length="491" mass="52256" checksum="6E94A9BB523A8D6D" modified="2023-06-28" version="1">MRSENVQSSAGVLRNFARKGARRCPAHGPPAGAVPQPSAARRAAAHSPCARCSPKVARAGSGEDSGDRELLPERASERASERVYPPLEDYLEDMEERSAETKSNVDSSAQPSVAQLAGRFREQAAVARETPASKPTRRKPPCSLPLFPPKVELGQNGEEKSPSSTSHPPKIKVKSSPLIEKLQANLAFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGIRSQPGEAEEVPVSFDQPPEGTHLPSYTKVRTRGSIKRRPPSRRFRRSQSDCGDILDYRAVEPSQENGAGVENGDDVFSNKSKAPRSRPPNQEAMGDRVEGTPESTEKPPQRSIYNSMEKPEEQVATPGETSAGEEAGQNPDTASQGSLEAPELPHTCSTEAENGCGSPAEGTATEEHTDTGKATDGTASEESVADEEEGEIREKPPQGSSGRVEGTIIPEVETKQKEGPPVEPGCSPGVDNTSGETSNEVQNDHEACMDDNPMEDTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G3J5</accession>
    <name>A0A9J7G3J5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prolyl endopeptidase</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">Prepl</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14">17A/GY</strain>
            <tissue evidence="13 14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Interacts with the AP-1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_027273750.1">
        <property type="nucleotide sequence ID" value="XM_027417949.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273751.1">
        <property type="nucleotide sequence ID" value="XM_027417950.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G3J5"/>
    <dbReference type="GeneID" id="100762687"/>
    <dbReference type="KEGG" id="cge:100762687"/>
    <dbReference type="CTD" id="9581"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000002">
        <property type="entry name" value="prolyl endopeptidase-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000050">
        <property type="entry name" value="prolyl endopeptidase-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051543">
        <property type="entry name" value="Serine_Peptidase_S9A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757:SF19">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757">
        <property type="entry name" value="PROTEASE FAMILY S9A OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="11">
        <location>
            <begin position="102"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="10">
        <location>
            <begin position="484"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027273750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027273751.1"/>
        </source>
    </evidence>
    <sequence length="721" mass="83390" checksum="25395910314AB12D" modified="2023-06-28" version="1">MQQTTKLFLRALKYSIPHLGKCMQKQNYCNFADRYYNRIRLKKYHLQNKSKISELARHIPSRSFSCKDLLPIKPENEKSLSENMDAFEKVRTRLETQPQEEYEIINAEIKHGSFVYYQEGCCLVRSKDEEADSDNYEVLFNLEELKLEQPFIDCIRVAPDEKYVAAKIRTEDSETSTLIVVKLSDQPVMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFGENRRNERFYTEKDPSYFVFLYLTKDSRFLTLNIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNVGEPTEFKLMRTAADAPAIMNWDLFFTMKRNTKVVDLDMFKDHCVLFLKHSNLLYVNVIGLADDSIRSLKLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRIEAKSKDGKLVPMTIFHKMDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGCLTKKLNGLADLEACIKTLHSQGFSQPSLTTLSAFSAGGVLVGALCNSKPELLRAVTLEAPFLDVLNIMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPCQNIKPQHYPSIHITAYENDERVPLKGIVNYTEKLKEAIAEHTKDAGEGYQPPNIILDIQPGGNHVIEDSHKKITAQMKFLYEELGLDSTNAFEDLKKYLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G6D3</accession>
    <name>A0A9J7G6D3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LOW QUALITY PROTEIN: zinc finger protein 79-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC103160509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027277689.1">
        <property type="nucleotide sequence ID" value="XM_027421888.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299070.1">
        <property type="nucleotide sequence ID" value="XM_035443179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G6D3"/>
    <dbReference type="GeneID" id="103160509"/>
    <dbReference type="KEGG" id="cge:103160509"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000605">
        <property type="entry name" value="zinc finger protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000944">
        <property type="entry name" value="zinc finger protein 232 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002278">
        <property type="entry name" value="Zinc finger protein 320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000427">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="249"/>
        </location>
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        <location>
            <begin position="250"/>
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        </location>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027277689.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31736" checksum="733EDAB42926F37D" modified="2023-06-28" version="1">MSVRKAFSYYSDFVLLQIIHTGEKPYECNECGKAFSQSIHLTLHQRIHTGEKPCKCQECGLAFSHRSALIQHHISHTGEKPYECNDCGKAFNQSSYLTQHQRIHTGEKLYECKECGKAFSQSTFLTQHQGVHTGEKPYKCNECGRAFSDRSGLIQHQRTHTGERPYECNVCGKAFGYCSALTQHQGTHTGKKPYKCSVCAKAFNDRSALIGYQRTHTGEKPCKYKDCGKAFSQSSSLTKHQKTHTGEKPYKCKECGKAFSQSSSLSQRQKTHAGGRSIWTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GA56</accession>
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            <fullName evidence="8">ADAMTS-like protein 2</fullName>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
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            <taxon>Cricetinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with LTBP1.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027278814.1">
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    <dbReference type="GeneID" id="100761699"/>
    <dbReference type="KEGG" id="cge:100761699"/>
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    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF19236">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
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    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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    <feature type="chain" id="PRO_5039918358" description="ADAMTS-like protein 2" evidence="11">
        <location>
            <begin position="30"/>
            <end position="957"/>
        </location>
    </feature>
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        <location>
            <begin position="918"/>
            <end position="956"/>
        </location>
    </feature>
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            <begin position="533"/>
            <end position="564"/>
        </location>
    </feature>
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            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
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            <begin position="59"/>
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        </location>
    </feature>
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            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027278814.1"/>
        </source>
    </evidence>
    <sequence length="957" mass="105710" checksum="35533612A059253C" modified="2023-06-28" version="1">MDGRWQHSHWAWSLLAMAVVAGGTASTEASDNSPTSNSLEGGADATAYWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGAGNRTCVGTSKRYQLCRVQECPPDGRSFREEQCVSFNSRVYDGRAYQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGVCQGDGSSCTHVTGNYRKGNNHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGFYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHTHHLQPVYYSFSEPASESTESTEGQELDSARLLGFMQHNGSLYHQASSERLGLNNKLFQSPVPEVELGPSRGQETNEVCERASGGACEGPPRGKGFQDHNATGIALSGDKDDQEVDTRFTSQELLSANAISDQLLGTGSDSEEFSLNETMNSVFSQGAPRNSPAESLYVDYEENEGPAAYLINGSYLELSSDRINTSSEAPFPNTSASLPTLAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSTYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGHQFRIVRCWKMLSPGFDSSVYSDLCEATEAVRPEERKICRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPSTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQMRSGPECGLSRKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCSHWYYSKACCRSCRPPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GFB3</accession>
    <name>A0A9J7GFB3_CRIGR</name>
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        <submittedName>
            <fullName evidence="4">Transmembrane protein 72</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Tmem72</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027285025.1">
        <property type="nucleotide sequence ID" value="XM_027429224.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A9J7GFB3"/>
    <dbReference type="GeneID" id="100759477"/>
    <dbReference type="KEGG" id="cge:100759477"/>
    <dbReference type="CTD" id="643236"/>
    <dbReference type="OrthoDB" id="5946061at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032055">
        <property type="entry name" value="TMEM72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28474">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28474:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16054">
        <property type="entry name" value="TMEM72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027285025.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30093" checksum="4F0BF87B568D1EAE" modified="2023-06-28" version="1">MKLQVFWTGLEYTCRLLGITTAAVLIGVGTETFLRGQFKSLAFYLLFTGVTISVCEGTYFVAQLLAICFKCQPGSLAHRAKEKAHWLGCFQKFLAYMLLSVACFLHPVLVWHVTIPGSMLIITGLAYFLLSKRKKRKAAPEVLAPTEQYTDPSSSTVSTTGSGNTEQTYTFHGALREGPGSFFNHMKSIMKGTKKPRVPQPQDTLMELALEPADSLAKKKQVHFEDSTVRIIPSITEGPGDSDSGPEETASDTTPIISSTRTPLFLPSLMGADLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GIB6</accession>
    <name>A0A9J7GIB6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Doublesex- and mab-3-related transcription factor C2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Dmrtc2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027286418.1">
        <property type="nucleotide sequence ID" value="XM_027430617.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GIB6"/>
    <dbReference type="GeneID" id="100759114"/>
    <dbReference type="KEGG" id="cge:100759114"/>
    <dbReference type="CTD" id="63946"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031577">
        <property type="entry name" value="DMRT-C1/C2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF126">
        <property type="entry name" value="DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15791">
        <property type="entry name" value="DMRT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="10">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="8">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027286418.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="39109" checksum="599037FEEBCB7FA8" modified="2023-06-28" version="1">MDPNEAPALHHCSADSSPGIETRVPQSTELIPRRPVSRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLAQGLMKGATPLKASLRVKKGAIRPGVPSGKENIAPQPQSPHGAVPLVLTPPGKENYGPLLLSRPQEALPLPWTPVPPGPWGPGHWLPPGLSMPPPVVCRLLCQEPAVPLHPFPGFDPGTSLRLPTHGTLPTCPGSRSVLAAPLSGEPQGPPNLPHTCSTLILQSCGTPDSLLLQPQAPGASCLAWTSGPSERQLQREAAEALVGLKDSSQAPRLTPSVPPNPAWISLLHPCGPPAPPAGRGFQPAGPPLRPSPASSVSLHIGRLGSISLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJH0</accession>
    <name>A0A9J7GJH0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Prdx4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="RefSeq" id="XP_027288512.1">
        <property type="nucleotide sequence ID" value="XM_027432711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GJH0"/>
    <dbReference type="GeneID" id="100763245"/>
    <dbReference type="KEGG" id="cge:100763245"/>
    <dbReference type="CTD" id="10549"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039910117" description="thioredoxin-dependent peroxiredoxin" evidence="9">
        <location>
            <begin position="38"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="82"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027288512.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34109" checksum="29685EEEAF066071" modified="2023-06-28" version="1">MEARSKLLDATTQSRRWTQKLVLILPPLLLFLLRTEALQGLESEDRFRTRENECHFYAGGQVYPGEVSRLSAADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDLILYSPGIFYMELEYNVEEELSRSRSTFVCPTEIIAFGDRIEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GJU7</accession>
    <name>A0A9J7GJU7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FERM and PDZ domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PDZ domain-containing protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PSD-95-interacting regulator of spine morphogenesis</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Frmpd4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7; the interaction is mediated by the PDZ domain. Interacts with GPSM2 (via TPR repeat region).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027287647.2">
        <property type="nucleotide sequence ID" value="XM_027431846.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100768458"/>
    <dbReference type="KEGG" id="cge:100768458"/>
    <dbReference type="CTD" id="9758"/>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13183">
        <property type="entry name" value="FERM_C_FRMPD1_FRMPD3_FRMPD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17170">
        <property type="entry name" value="FERM_F1_FRMPD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21943">
        <property type="entry name" value="LGNbd_FRMPD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06769">
        <property type="entry name" value="PDZ_FRMPD1_3_4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000009">
        <property type="entry name" value="FERM and PDZ domain containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000066">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000053">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049385">
        <property type="entry name" value="FAK1-like_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041779">
        <property type="entry name" value="FRMPD1/3/4_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF4">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21477">
        <property type="entry name" value="FERM_C_FAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="164"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="769"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="857"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="907"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1164"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1277"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1164"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027287647.2"/>
        </source>
    </evidence>
    <sequence length="1719" mass="188912" checksum="52BAEE21E3D14209" modified="2023-06-28" version="1">MMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEENLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGTENKGKHNILGSDWNCMPQMTTFIGEGEQEAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNTYSSDELSQPLTQPGDAPCETNYRSLAQRSLMTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSTPTVGYERLLDENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSESSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKELDPSVVSTLEALEALSEEQQKSDNSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLTEEQTEFPTSKAPSGVLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLAEGEGKAPLSGTALGKKQQGTKMAEMEEDTKGKVGTVSSRDSPHLSTFNLERTAFRKDSQRWYVASDGGVGEKSGVEAPAMRAFPRGPGLGNREAEGKEDVAVEGEADNGSGLDQGDRFLTDMACVASAKDLENPEDADSPTCDHATKLPEAEDSVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSTCATPVESPLCPSMGKHLIPDASGKGGSYISPDDRVSGHPNHGTTFKELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTALTEPGKERQGGMPSAWSQHPEADPILLPSNIHLESKVPSPNQDPNDFSQANQAFGEAVSWWPADLRGGSLMTPPSQRALRQSSSVLSGPVGLETFQERTKGAVSLKYPGITEAQEVSSERRAELPLGKKLTKSFSQSSMHFISEGKFHKRSPVSYKDSKLYRTLPLRKLEGSNWRCRGPFSYCFLNQGQDEDGDEDEEEAEATLQVSCLYQPQITQAMQEPSKSSLVVGLQNQGEPSRGPVLKVWTEDPSGPDDVDLSSLAFDARIARINALKASTYGMPNGFLEAQNDANELLCLVRATKAKREESRPEAYDLTLSQYKQLLSIESRQLGSACRKMAMAEKSPEEMLLAMSSSFQVLCCLTEACMRLVKVVNSETQRQEIVAKIDEVVINYICLLKAAEAATGKTTGDPSIGLSMRHSTTMAAIVSTLTRSLKMLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GK17</accession>
    <name>A0A9J7GK17_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Mmgt1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Early endosome membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289193.1">
        <property type="nucleotide sequence ID" value="XM_027433392.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027290634.1">
        <property type="nucleotide sequence ID" value="XM_027434833.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GK17"/>
    <dbReference type="GeneID" id="100764155"/>
    <dbReference type="KEGG" id="cge:100764155"/>
    <dbReference type="CTD" id="93380"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027289193.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20050" checksum="C8472FE450B874C7" modified="2023-06-28" version="1">MTSCSCAAWTPAGERRNSSTALRLLLLDCRSFRIMAPSLWKGLVGVGLFALAHAAFSAAQHRSYMRLTEKEDESLPIDIVLQTLLAFAVTCYGIVHIAGEFKDMDATSELKNKTFDTLRNHPSFYVFNHRGRVLFRPSDAASSSNLDALSSNTSLKVLGILKKPCNNCILQHKSQMVFSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GK64</accession>
    <name>A0A9J7GK64_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">ETS-related transcription factor Elf-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">Elf4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13 14 15">17A/GY</strain>
            <tissue evidence="13 14 15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027289288.1">
        <property type="nucleotide sequence ID" value="XM_027433487.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289289.1">
        <property type="nucleotide sequence ID" value="XM_027433488.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289290.1">
        <property type="nucleotide sequence ID" value="XM_027433489.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289291.1">
        <property type="nucleotide sequence ID" value="XM_027433490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GK64"/>
    <dbReference type="GeneID" id="100771659"/>
    <dbReference type="KEGG" id="cge:100771659"/>
    <dbReference type="CTD" id="2000"/>
    <dbReference type="OrthoDB" id="8196042at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000066">
        <property type="entry name" value="ETS-related transcription factor Elf-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022084">
        <property type="entry name" value="TF_Elf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF170">
        <property type="entry name" value="ETS-RELATED TRANSCRIPTION FACTOR ELF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12310">
        <property type="entry name" value="Elf-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ETS" evidence="11">
        <location>
            <begin position="208"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027289288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027289289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027289290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027289291.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="71456" checksum="CE5BC29E137DB9FC" modified="2023-06-28" version="1">MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPELLHLYSGLDLDDVHNGIIRDRTVCMTQDQILEGGILLADDNESTSQNVSPTEVLFNVETPNDVLDEKQIFSTPEILADTDSVQAINLPNFLFSATEPEDPKKTSDTGDQKEQPVEERVSRDESPKKMGKTRKRSRKTKNNRSTSPVTDPSIPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIEDDDENTETPEVPPPQASTSSTPSTSTIRRASSRASNRASAQDKDSLSWEKPKVQHAGLQPSASLELGLSVDDEVPTTSTLLVSPIQSQATLTKTVSTSSVPSNIHLGVAPVGPGSTVTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPQVSTFKDTFTLQASFPLNTTFQESQVATQGAPLILSGLPQLLAGANRPSNPVATQVIGAGSAGPSSQPPGTVIAAFIRTSGGTSVPGVKEGPLRSPSYVQGVVTGAPVEGLLVPEETLRELLRDQAHIQPLQSQVLSRGSHNLSLVGSQTLSPPSRPTVGLTPVAELELSSGSGSLFVAEPSVTTSGNLLTTSPTPASFSPFNPTSLIKMEPHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMV6</accession>
    <name>A0A9J7GMV6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Taste receptor type 1 member 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Tas1r1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003510261.1">
        <property type="nucleotide sequence ID" value="XM_003510213.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035295266.1">
        <property type="nucleotide sequence ID" value="XM_035439375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GMV6"/>
    <dbReference type="GeneID" id="100759079"/>
    <dbReference type="CTD" id="80835"/>
    <dbReference type="OMA" id="EDWAIST"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050917">
        <property type="term" value="P:sensory perception of umami taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06363">
        <property type="entry name" value="PBP1_taste_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF3">
        <property type="entry name" value="TASTE RECEPTOR TYPE 1 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0919">Taste</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039917310" evidence="15">
        <location>
            <begin position="21"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="16">
        <location>
            <begin position="566"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035295266.1"/>
        </source>
    </evidence>
    <sequence length="841" mass="93379" checksum="6F5299D542E74C9A" modified="2023-06-28" version="1">MFVWAAYLLSLQLPIAFCWAYSCHKTESSPGFSLPGDYLLGGLFALHSDCLQVRHRPQVTRCDRPNSFNGHGYHLFQAMRFSIEEINNSTALLPNISLGYELFDVCSESANVYATLRVLAQRGTGHLEMQRDLHNYSSKVVALIGPDNTDHAVTTASLLGPFLMPMISYEASSVALSTKRQYPSFLRTIPSDKHQVEAMVLLLRSFGWVWISLIGSYGDYGQLGVQALEELAAPQGICIAFKDIVPFSAQVGDPKMQQMVHRLAQARTTVIVVFSNRYLARVFFMSVVLANLTGKVWIASEDWAISTYITKVPGIQGIGTVLGVAIQRRRVPGLKEFEESYIREVKGSPRSCPEGSWCSTNQLCRECHTFTTQSMPWLGAFSMSAAYNVYQAVYAVAHGLHQLLGCTSETCSRGPVYPWQLLQQIYKVNFLLQKDTVAFDDNGDPLGGYNIISWDWNGPEWTFEVIGSASVSPVQLDINKTKIQWHGKNNQVPTSVCTTDCLEGHHRVVVGSHHCCFECIPCEAGTFLNKSDLHICQPCAKEEWAPEGSTTCFPRTVEFLAWQEPISLVLLTANTLLLLLLVGTTGLFARHLHTPVVRSAGGRLCFLMLGSLAAGSCSFYGFFGEPTVPTCLLRQPLFSLGFAVFLSCLTIRSFQLVIIFKFSTKVPTFYHTWAQNHGAGLSVTASSTVHLLICVLWLAVWTPLPTREYQRFPHLVILECTEVNSAGFLLAFTHNILLSVSTFACSYLGKELPENYNEAKCVTFSLLLNFVSWIAFFTTSIIYQGSYLPAVYVMAGLATLSGGFSGYFLPKCYVILCRPDLNNAEHFQASILDYTRRSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GUC0</accession>
    <name>A0A9J7GUC0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Slco2b1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297242.1">
        <property type="nucleotide sequence ID" value="XM_035441351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GUC0"/>
    <dbReference type="GeneID" id="100763633"/>
    <dbReference type="KEGG" id="cge:100763633"/>
    <dbReference type="CTD" id="11309"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015125">
        <property type="term" value="F:bile acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF87">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="176"/>
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        </location>
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        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
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        <location>
            <begin position="471"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035297242.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="74427" checksum="B682E38FE8722B73" modified="2023-06-28" version="1">MPDRDTKTTMSTEDTHESKVSMEPQDSNQDAQPRGLFHNIKFFVLCHSILQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLAAFNEVGNVSLILLVSYFGSRVHRPRMIGYGAILVALAGLLMALPHFISEPYRYDHNSPDRSQDLDVSLCLPTTLAPAAAVSNDSCSSNTEAKHLTMVGIMFTGQLLLGIGSVPIQPFGISYIDDFAHHSNSPLYLGILFAATTVGPAMAYGLGSLMLRLYVDIDRMPEGGINLTPKDPRWVGAWWLGFLISVGLVVLAAIPYFFFPKEMPKEKHELRLRRKVLAGTASTVNKGEELSSQHEPLKKETGLAQIAPDLTIVQFIKVFPRVLLRMLRHPIFLLVVLSQVCTSSMVAGLAIFLPKFLERQFSITASFANLLLGSLTIPLSIVGIVLGGVLVKRLHLSPVQCSLLCLLGSLLCLLLTLPLFFIGCSTHHIAGITQGLGAQPGPSLFPGCSEPCSCQPNDFNPVCDTSARVEYTTPCHAGCTGHVVQEVLGKRQVFYTNCSCVAGDGAVSAGSCDSACSNLILPFILLISLGVAVASITHTPSFMLILRGVKKEDKILAVGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALSCGWQAVCRYYDHDLLRRRFIGLQFFFKSGSLVCFALVLAILRQQNKEASMKVIVKSSDLQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H326</accession>
    <name>A0A9J7H326_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pleckstrin homology domain-containing family A member 6 isoform X10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Plekha6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035301393.1">
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    <dbReference type="GeneID" id="100767864"/>
    <dbReference type="CTD" id="22874"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000083">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
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    </dbReference>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057971">
        <property type="entry name" value="PKHA4-7_TBCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1"/>
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            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
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            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
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            <end position="1144"/>
        </location>
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            <begin position="589"/>
            <end position="654"/>
        </location>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
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            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
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        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
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        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
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        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
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        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035301393.1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128166" checksum="91039BE5A43F2810" modified="2023-06-28" version="1">MSNKTGGKRSATINDNSNNMVSEVPPERPNNRATRTSRKAIAFGKRSHSMKRNPSAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQPVRHSHEKSDSENIPPSKIHQQPPHNSLAKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPLVKANGLPSGPESASEPGSPYPDGPRVPGGGEQPAQPNGWQYSSPSRPGSTAFPPHDGNTGGHRQSFPPRTDPDKIAQRKSSMNQLQQWVNLRRGVPPSEDLRSPSRFYPVSRRVPEYYSPYSSQYPEDYQYYPPGVRPDSICSMPAYDRISPPWALEDKRHSFRNGGGPTYQLREWKEPASYGRQDSTIWIPSPSRQPVYYDELDAASGSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSARFDRLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNYPPSPTVHDKMDDLLDLQLQRNLEYLDQQVPAYPEVFRDGLHTFKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGNQPAYPEKLLHKKESLQNQLINIRVELSQATTALTNSTVVYENLESEVSALHDDLWEQLNLDIQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSMVSGSQGSPTKPGSSEEPGPPRPPLPKAYVPLDSPPTVPPLPNESRFWPYPNSPSWHHSGETARGQPKTGYEPNKKDPDQTSPLDTPRDISLVPTRQELETEKQAALNKVGIVPPRTKSPAEEEMTPSAVVRRTTNGLTNGLSSRQERPKSAVFSGEGKVKMSVEEQIDRMRRHQSGSMKEKRRSLQLPASPAPEPSTRPTYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPTPPVNPLSSERPRGADSSHTMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H362</accession>
    <name>A0A9J7H362_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-Fucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Fut2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:82639"/>
            <dbReference type="ChEBI" id="CHEBI:90189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:48293"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_035302475.1">
        <property type="nucleotide sequence ID" value="XM_035446584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H362"/>
    <dbReference type="GeneID" id="100751185"/>
    <dbReference type="KEGG" id="cge:100751185"/>
    <dbReference type="CTD" id="2524"/>
    <dbReference type="OrthoDB" id="3226at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF5">
        <property type="entry name" value="GALACTOSIDE 2-ALPHA-L-FUCOSYLTRANSFERASE SEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035302475.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32113" checksum="4A8EBF7DA30E0595" modified="2023-06-28" version="1">MFTINVKGRLGNQMGEYATLFALARMNGRPAFIPASMHSALAPIFRISLPVLHHDTDRKIPWQNYHLNDWMEERHRHIPGRYVRLTGYPCSWTFYHHLRPEILQEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPNVWKGVVADRGYLEQALDMFRARYRSPVFVVTSNGMAWCKENINASRGDVVFAGNGIQGSPARDMSLLLQCNHTIITVGTFGIWAAYLTGGDTVYLANFTQPSSPFNMIFKPQAAYLPNWVGIAADLGQAQQRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H4X7</accession>
    <name>A0A9J7H4X7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein archease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein ZBTB8OS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100752194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303151.1">
        <property type="nucleotide sequence ID" value="XM_035447260.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035316285.1">
        <property type="nucleotide sequence ID" value="XM_035460394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H4X7"/>
    <dbReference type="GeneID" id="100752194"/>
    <dbReference type="KEGG" id="cge:100752194"/>
    <dbReference type="OrthoDB" id="2190767at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.10.10:FF:000001">
        <property type="entry name" value="protein archease isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="entry name" value="Archease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682:SF11">
        <property type="entry name" value="PROTEIN ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="MTH1598-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="9">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035303151.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="15040" checksum="CBD0F4BC270106AE" modified="2023-06-28" version="1">MAQEEEDGRDYNLMEEQKAIKDKYLPANQKYEYLDHTADVQLYAWGDTLEEAFEQCAMAMFGHMIETKTVKPLQTVEVETQGDDLQPLLFHFLDEWLYKFSADEYFIPWEVKVLNIDQKNFKLRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H552</accession>
    <name>A0A9J7H552_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein Shroom1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Shroom1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shroom family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303759.1">
        <property type="nucleotide sequence ID" value="XM_035447868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H552"/>
    <dbReference type="GeneID" id="103159804"/>
    <dbReference type="KEGG" id="cge:103159804"/>
    <dbReference type="CTD" id="134549"/>
    <dbReference type="OrthoDB" id="10063560at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014800">
        <property type="entry name" value="ASD1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014799">
        <property type="entry name" value="ASD2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027685">
        <property type="entry name" value="Shroom_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012:SF37">
        <property type="entry name" value="PROTEIN SHROOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08688">
        <property type="entry name" value="ASD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08687">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51306">
        <property type="entry name" value="ASD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51307">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASD1" evidence="10">
        <location>
            <begin position="146"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ASD2" evidence="11">
        <location>
            <begin position="532"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="729"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="603"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_035303759.1"/>
        </source>
    </evidence>
    <sequence length="839" mass="90348" checksum="2B880DE89A020DEA" modified="2023-06-28" version="1">MEALGTGSDRTSPASATGSLDLRRLSTTRADSAYSSFSAASGGPEMRTPSPGTELLPYLDCDYVRVVWGSRSPTPQDTILPTTQRPEPVVAGHSDPRPPEVQGSPGSLSRQDTPLLYALAAEAEAAARTAEPPSPPASRDAYRQRLQGAQRRVLRETSFQRKELRMSLPGRLRPWLSQRPPTLHARSASSSHEGGEAEPARTVVPALGAAGPGRLARQQRMCCFSEPGKLHRMGWSCGPTGEGLREACSTQELQRGAHAKSKGLQETQSLSLVELDSPSVNLGNGCRPAGRSQSISVMVMGPRAGSERKVAAPVQAVPQRTETPRPLLQMKLSRFLTQKEATVVCPAEVFQGSPAGCGQGVPETFRVSTPHPSLPDDDVFLEEAETPPPQDSHGPQGLPTSSSRDLHVCDQPNDLSKKAGGTTVSADSPFHEGPGTTGADDNWGEGVNGSVGFSRPTSCSPPGTTNDDIPTIHATGQLAMDPSTATEDNPLKPPSVDGLQPLGSGTPGPPHHTSLTRGQPTPKPTWPSRHFEELVQQLARLDPSLSDTFAAQPGPELPLGLLDGLFPATEVWAVMRPACEAAGEEAAGASDAGSSGSHFAQKLPTQEATRSENTTPNAVPYQSKSQGLPKPNSTQAKKVELARLLQKMLQDLQAEQERLRGKSADWTRCLGALEVAVSQACTPRELERFRRFMIDLERVLGLLLLLGSRLARVNLALAKAGSDSDPDEKASLLQRLRLLQRQQEDAKELKEHVARREQALRQVLERELSTEHLRSYCVLLVAKARILSQQRSLDDRIRFLKDQLDTIWSDLSHHPLSSRLSWAPGIGHLDKPLFPATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H7K4</accession>
    <name>A0A9J7H7K4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Exoc6b</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304717.1">
        <property type="nucleotide sequence ID" value="XM_035448826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H7K4"/>
    <dbReference type="GeneID" id="100757038"/>
    <dbReference type="KEGG" id="cge:100757038"/>
    <dbReference type="CTD" id="23233"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000001">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000001">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF3">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="392"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_035304717.1"/>
        </source>
    </evidence>
    <sequence length="782" mass="91130" checksum="5D1EF7778E8AD2B6" modified="2023-06-28" version="1">MEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQDEYMSLPAEPFLQSQFKYLKAQQQRNLDNIVLQQPRIGSKRKSKKDVYTIFDAEMESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGVFRNILDSDNYSPIPVTSEETYKKVVGQFPFQDIELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLDNKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H8G7</accession>
    <name>A0A9J7H8G7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC103159203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306498.1">
        <property type="nucleotide sequence ID" value="XM_035450607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H8G7"/>
    <dbReference type="GeneID" id="103159203"/>
    <dbReference type="KEGG" id="cge:103159203"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
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        <source>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="5 6">17A/GY</strain>
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            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_035305442.1"/>
        </source>
    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="12">Patched domain-containing protein 1</fullName>
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        <name evidence="16" type="primary">Ptchd1</name>
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    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention. Can bind cholesterol in vitro.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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            <location evidence="1">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the patched family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_035449750.1"/>
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    <dbReference type="OrthoDB" id="10027883at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Patched domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Patched domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
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        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
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        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF36">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="43"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059560"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035305641.1"/>
        </source>
    </evidence>
    <sequence length="933" mass="105817" checksum="7797617C6200A04A" modified="2023-06-28" version="1">MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKVRVGRVRAAPGGSAAVAGLAPRGVPAEKAASAIPRGGCCRVFPCTLHTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHLKDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKLFQKSNSKVKIYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEVLQEKPAWYRFLLTARFSEDTAEGEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAQQKYFSNYSPVIGFYIYESIEYWNSSVQEDVLEYTKGFVRISWFESYLNYLRKLNISTDLPKKNFTDMLRNSFLKAPQFSHFQEDIIFSKKYNDEFDVVASRMFLVAKTMDTNREELYDLLETLRRLSVTSKVKFIVFNPSFVFMDRYASSLGAPLHNSCISALFLLFFSAFLVADSMINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPPSKKKRKEKKNPENREEIECVEMVDIDSTRVVDQITTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCX3</accession>
    <name>A0A9J7HCX3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sperm-associated antigen 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Spag17</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035307203.1">
        <property type="nucleotide sequence ID" value="XM_035451312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100772829"/>
    <dbReference type="KEGG" id="cge:100772829"/>
    <dbReference type="CTD" id="200162"/>
    <dbReference type="OrthoDB" id="10257153at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026173">
        <property type="entry name" value="SPAG17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963">
        <property type="entry name" value="PF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963:SF1">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1928"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1934"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1980"/>
            <end position="2028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035307203.1"/>
        </source>
    </evidence>
    <sequence length="2295" mass="259605" checksum="2089348D0DBF21D7" modified="2023-06-28" version="1">MAPKKEKVTPNTNSRIWEPSLISAQLNQNDWKASIAFVVGNRIEDFLLIEALGMAVQYPQRKLFSLVSWQDILQQIDEIQSLAAAVSSKKGKKPPNGGLPLYYEVLMAARVIMDSGEKLTLPLIGKLLKFQLLQIKLKDQQRQENEKKMVEDRAKSEKDKGKVKSPKEKKSGSAKAGKGKGKDQPEAAAAVKKSTQLKRRGDDDDIKAYIDDEPDDGAQHYIIVVGFNNPQLLAIMTELGISIASVIKISSENYEPLQTYLEAVRQQQEAILQPEEIEAEELKTQRSIKELENFWKYLEPILNNEKPETNLFDVARLHYTVNMAYFPSDWSDHEMMLDLGTEIFENVACLMYDSLDWKRQHQHYLESMHLINVPQVVSEKTMLEAMPIPEPPPPTAPAPGKKKPQYEEPQAPPTVAFIITTDVDMRYYNDLLNPIPEEFISVPLILHCMLEQVVATEEDLIPPSLVEPRPRADGLDFRIAAHIVSILPSLCLSEKEKKNLQEIFLAEGESESKALPKGPLLLNYHDAHSHKKYALKDQKNFDPVQIEQEMQSKLPLWEFLQFPLPPPWNSTKRLATIHELMHFCTNEVLSWNEVERAFKVFTFESLKLSEVDEAGQLKPAEVVSQADAENINIPWDNPARFAKHIRQQCMHRANIQKAKPVADIGNKDRILFINQNLSRSEAEEYPDPNEPDVNSVRPSTSDTRRPLDAGNRELSEKETSGSMWPQSESLEQTMDSEIKDEAATKDDSPEKKPKKIVVEANLEDIKKTQQRSLTDWSFTEHFQPKVLLQVLQEAHQQYRCVDSYYHTQDNSLLLVFHNPMNTQRLHCEYWNIALHSNVGFRNYLELIAKSIQDWITEEEAKYQEAKMAEELNRTKIELELKASTSKISSSKSVSLKKSKSNKIVSKTEMPEQEKEKEKEKIPFILEGSLKAWKEEQERLAEEERLKEEKKAEKKAEKKGKDAGKKKGKDKVENLIEETKILKKKSSSKEKAKEDPVKIPETIEESFPLPEPETVYPFRGYNMGDVPVKITGKNYYLYPSDGGQIEVEKTMFERGPTFIKVKVKKDKHNFIIHLKDPKEIVKKDKEEDYSSEEEEEEETTQVVNEAVSKFGSFSATLENGICLSISYYGANGMAPEVTDPELETIMNIPSALIATVIPTIVTVPQGKVKPKVKGKEKPKESLKEEEHPKEEEKKNYVPEEAEPEIVIQEPSYVPTFQNLNVSCPNGLLLTFIGQESTDHPIVDEEPTWDLMIRQSYPQRVKHYEFYKAVMPPMEQEASRVVTSQGTVIKYMLDGSTQVLFADGAVSSSPDSGPVYTSPDLSTSPHNGDLVDSASQPKSETAPSEIVITKKGKGHKNQTSVAHKNETHDTLPGVVPTVPTTIETHTGTWFTTTPDGNRIGTKGLEKIEHLKPYLSFQATDPINGTVMTTREDKVIIVEKKDGTRIVDHADGTRITTFYQVYEDHIIPPDGEETTEGPGTVTRQVKCMRIESSHYATIITNCEDSSCCATFGDGTSIIAKPQGSYQVLPPNTGCLYIDRDCSATYCHESSSNIYHPFQKREQLRASRYIMKHTSEVICEVLDPEGNTFQVMADGSVSTMLPKRKLEDDANVQTEGYDSLSSTHLEKNHMQIYGEHVPRFFVIYTDGSGMELLRDSDIEEYLSLAYGESTTVVLQEPVQEHPGALSITVLRPFHEASPWLMKKELNTIVPRNLQSRSWETFPSVEKKTPGPPFGTQIWKGLCIGSKQLTNAPAPILKGPRVLQMRQFIQHEVIKSEVKLRLQISLKDYINHILKKEDELQEMTVKDSRTEEERGNAADLLKLVMSFPKMEETTKSHVTEVAAHLTDLFKQSMDLTPKYSPDSFAKEFFEKKWRTTSSAKSWKEKLEKQREIIEKTQRYLIQIRNKEVTPYFNSELSPLFKTQYNYLKNLSKNLPPFPKKNETTTKPDVSDPDSDSTLTADVEQEAKNTPPLPKQEVAENMKKPASQSDAENVTKSIKRSPSQNTPENLVQYTQESDTQSKTETITKSPKESANQKCIIKLKKSTKKSTSQNQIENLKYTKESASQNQVENVTRPPTEEPDFFMPIKIPTQSLLQDVTGQARKEKVRLPHYLMSSKPKCQPLAKVEDCVGGKVNTSSIASAVIHNTNAAPFGFHLLPPSVKFGVLKEGQTYATTVKLKNVGVNFCRFRVKQPSPSTGLKVTYKPGPVAAGLHAELKIELFAMALEDDGTKGLAHISHNIEIMTEHDILFLPVEAIVLTSSNYDNRPKNFPQGKENPTVYKTSTISSSALGVFTSRKATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J772</accession>
    <name>A0A9J7J772_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger protein 318 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Znf318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027244993.1">
        <property type="nucleotide sequence ID" value="XM_027389192.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100757338"/>
    <dbReference type="KEGG" id="cge:100757338"/>
    <dbReference type="CTD" id="24149"/>
    <dbReference type="OrthoDB" id="9909793at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055309">
        <property type="entry name" value="Znf318-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15577">
        <property type="entry name" value="ZINC FINGER CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15577:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1-type" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="U1-type" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1447"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1606"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1718"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1905"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2172"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1465"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1628"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1726"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2184"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2225"/>
            <end position="2235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027244993.1"/>
        </source>
    </evidence>
    <sequence length="2235" mass="246525" checksum="6CA0CEC7EF46860F" modified="2023-06-28" version="1">MYRSGSRSSVSSHRAKDGGVSGPRPGRPGGASSGPARRPSSPPPSTSSSLRLPARRHRSPSGHRGRRASPSPPRGRRGSPSPPRGRRASPSPPRGRRASPSPPRGRRVSPSPPRARRGSPSPPRSRRLYPPGLAGFRGSTRGESRADFARDGRGDHPGDGGSRRHSPGLCSDSSLEQSLRITVGNDHFCVNTPERRRLSDRLGSPVDNLEDMDRDDLTDDSVFTRTSKCSRGLERYISREEGPLSPFLGQLDEEYRARETFLHRTEYSPHVSCHDELLRGAERNREKLKSSSYSIRAEERSRETKRPRYDDTEKVHSIGGDHSSFTSGTRNYRQRRRSPSPRFLDPEFRELDLARRKREEEEEQNRSLGQELVGADDDQTSCSIPGLSNVLTTSEPGYSLHRPEEVSVLPKKSILKKRIEVDMKPSLQLESFSGSTSSSQDHSLYSEHSPLPLSGAIAAFASEIENKGTTVEADLKEPQSNLYQWGLLHETPKDNNPLAEKFDSFLCYKEKLNLKAEGLERHADFLLPHERASQDGSGFSRILSMLADSTSTQEKRRRSFPDIEDEEKFLYGDEEEDIKAESPPKSLGDSENKGSRQKASSVPSTPAIKLESLEESNPEYSKIHDLLKTIGLDIGVAEISKLAARTQERLHGKKPSSRSLADRRPSADRHFSADRGSSVEHSFITDRRSSDSHRLESRESHHSNTQSPEVSHPLPASPVDPYLLTKSSPPFLKADHPLGHVPGPEVVGSGFQSPVAVRCMMPSAPPTPIRLPHSAPLPQFYIPRASQFATPRIPPNYQGSVIPSAPFDAYRHYMAYTASRWPMYPASQPSSHTLQEPHRLIPTTKQTTHSSRPNLRVIPTVTPEKSKQEVSVLGSISVKQVPIQVSPSLIRYNPEKISDEKNRASQKQKVIEEREKLKTDQEARQKKMFYLRTELERLHKQQGHSGEMLRKKRREKDGHKDPLLMEVSRLQDSIMKDIAELHKETEEAEKKQSELDKVAQILGIDIFDKSLKSSNDSKESTEKPEKGEKSKSPERELLTSNSSSNNQESKVNEKSCIKNPNSAESLQPTSKQSDQPVAVYEYYDAGNHWCKDCNTICGTMFDFFTHMHNKKHTQTLDPYNRPWASKTQSEAKQDTVKRTDKITVPAKGSEFLVPITGFYCQLCEEFLGDPISGEQHVKGHQHNEKYKKYVEENPLYEERRNLDRQAGLAVVLETERRRQNELKRKLSEKPKEEKIEKKAKVVKEAKEDDKTSIELEDQLSEGGNSPEKGEVKRNASLKLPVREEIKKESSIASSFGKFSWKKPEKEEEKGSMVPLSAPKEDTIENSKDKDDGKAETGKTKPIKIKLSGKTVVAHTSPWTPVVTTSTQTKIRPNLPIPSMVLRKSGSATVSKPAPLNTFLSIKSSGTSARPLPVVKESSSDLLLPPDIISKAFGGEEVILKGSPEEKVELAEKNEPSQVPEQLLALPPPPPPPPPPPPPPPLVIPHLSAPSPAQANVLAPVKSNSVVSQTLGLGFQGPEILNSGLPVAFTASEQPAAIPSDETAPGVSESDRDQTLISMLVRPPPPLSSVFSEQAKKLEKRNLCLATANAKDLYDIFYSSGGKGAHETKLSGSPLANGENSSLFRTENSDISSTSTLNSSVSSEDLPQDSGLVTAPVNSKLEDPIPKGLVSIGKWSVVDHIDPKSRDSSYSFLQPLTRLYQNRPYEMVVPKTDTSAVWTSASFQSDTNKDRPPEGKIKSDLGEPGPPGTDSASHLSDTHCHTKGSQKLVEINFIDKQNKNQELGQSEDCREREMKRNTELKEKVAVEEEAGTNIGLHSIEDSNLNHGSRNTWEGEIGQPKLSTIDKEVEQSRKLMTGHENPSKVVIESNQSLASKRAKIDSFPSLLQNPKDVPELLLLSPPRSDMCLKKPETWESPKKPEGSPEKPGVEAVELQDTHPELTVAKESKALENFEATHLKAEGLVTLRNLGDVHADFRNVQIEQAHRSPTALSQKMCEENSVLSVVCNLSSPSDFEPIQSFSGFLLESPKTLVLNFGTEGEHSSSNSRNGRIASNCLETGHPVENVDHDLGGERTHQALDLLAGGMLSEEVKGTSQLPEDLLRVESTTVGPSGLGPSPCLPDLVDFVTRTSGAPKEKPCSPLCEPGDFLTCNSLGMGSPPLEIVNVSVSEVVSQASEDNDSALNLVKSPTSGSPSRDQVVGGNMDPQEITEQEAAVDVIPDHTRSSVHDYSSQDYLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7J9N0</accession>
    <name>A0A9J7J9N0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC100762631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APEX1. Interacts with FMR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027248795.2">
        <property type="nucleotide sequence ID" value="XM_027392994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7J9N0"/>
    <dbReference type="GeneID" id="100762631"/>
    <dbReference type="KEGG" id="cge:100762631"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="10">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027248795.2"/>
        </source>
    </evidence>
    <sequence length="327" mass="35512" checksum="5CEC85D4FDF9BDD9" modified="2023-06-28" version="1">MPREDRATWKPNYFLKIIQLLDDYPKCFIVGADNADSKQMQQIRMSLRGKAVVLMAKNTMMRKAIRGHLENNPALEKLLPHIRENVDFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKTSRGTIEILSDVQLIKTGDKVGASEATLLNMLNISSFSFGLIIQQVFDNSSIYNPEVLDVTEQTLHSRFLEGVRNVVSGCLQIGYPTVASVPHSIINGYKRGLALSVETEYTFPLAEKVKAFLADPSTFAAAALNTEQARDTAPVAAATTAAPAASAAPAKAEAKKESEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JC02</accession>
    <name>A0A9J7JC02_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone deacetylase</fullName>
            <ecNumber evidence="3 12">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Hdac7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_027252217.1">
        <property type="nucleotide sequence ID" value="XM_027396416.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035293016.1">
        <property type="nucleotide sequence ID" value="XM_035437125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JC02"/>
    <dbReference type="GeneID" id="100766171"/>
    <dbReference type="KEGG" id="cge:100766171"/>
    <dbReference type="CTD" id="51564"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000002">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046949">
        <property type="entry name" value="HDAC4/5/7/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF42">
        <property type="entry name" value="HISTONE DEACETYLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037911">
        <property type="entry name" value="HDAC_II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="17">
        <location>
            <begin position="568"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="161"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="368"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Contributes to catalysis" evidence="15">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_027252217.1"/>
        </source>
    </evidence>
    <sequence length="978" mass="105433" checksum="82C711E29665C0FF" modified="2023-06-28" version="1">MHSPGAGCPALQPDTAGSQPQPMDLRVGQRPTVEPPPEPALLALQHPQRLHRHLFLAGLQQQQRSAEPMRLSMDPPVPELQGAQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSMLSSFLPPVPSLPTEAPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAEPLGDSSPSSSSTPASGCSSPNDSEHGPNPALGSEALLGQRLRLQETSLAPFALPTMSLLPAITLGLPAPARADGDRRTHSNLGPRGPVLGNPHAPLFLHHGLEPDAGGTLPSRLQPILLLDPSVSHAPLWTVPGLGPLPFHFAQPLLTTERLSGSGLHRPLNRTRSEPLPPSATASPLLGPLQPRQDRQDRLKPHVQLIKTAISPPQRPAKPSEKPRLRQIPSAEDLETDGGGVGAVVNDGLEHRESGHGPPEGRGPVSLQQHQQVPLWEQQHLAGRLSQGSSGDSALLPLAQVGHRPLSRTQSSPAAPVSLLSPEPTCQTQVLTSSETPATGLVYDSVMLKHQCSCGDNSKHPEHAGRIQSIWSRLQERGLRSRCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLTGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQGKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGTGNGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFAPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMTLAGGAVVLALEGGHDLTAICDASEACVAALLGNKVDLLSEEGWKQKPNPNAIRSLEAVIRVHRKYWGCMQRLASCPDSWLPRVPGADAEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JDF0</accession>
    <name>A0A9J7JDF0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C-Jun-amino-terminal kinase-interacting protein 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Mapk8ip2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027252094.1">
        <property type="nucleotide sequence ID" value="XM_027396293.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JDF0"/>
    <dbReference type="GeneID" id="100754281"/>
    <dbReference type="KEGG" id="cge:100754281"/>
    <dbReference type="CTD" id="23542"/>
    <dbReference type="OrthoDB" id="5965083at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01212">
        <property type="entry name" value="PTB_JIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11942">
        <property type="entry name" value="SH3_JIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000108">
        <property type="entry name" value="C-Jun-amino-terminal kinase-interacting protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000032">
        <property type="entry name" value="Putative C-Jun-amino-terminal kinase-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047178">
        <property type="entry name" value="JIP1_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035637">
        <property type="entry name" value="JIP2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437:SF2">
        <property type="entry name" value="C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="609"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="8">
        <location>
            <begin position="688"/>
            <end position="817"/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">17A/GY</strain>
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            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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            <strain evidence="4">17A/GY</strain>
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</entry>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Dhiman H."/>
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                <person name="Griep S."/>
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        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">17A/GY</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
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    </dbReference>
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        <property type="entry name" value="DRMBL"/>
    </dbReference>
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        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="113"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="region of interest" description="Disordered" evidence="10">
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        <location>
            <begin position="552"/>
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        <location>
            <begin position="27"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="64"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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            <end position="481"/>
        </location>
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            <end position="535"/>
        </location>
    </feature>
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            <end position="663"/>
        </location>
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            <begin position="665"/>
            <end position="674"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027262723.1"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113826" checksum="A7BC50A324C0FDA5" modified="2023-06-28" version="1">MLEDEFWEEDIWKYKSKRKPKPAHPINCSQNISESVGRTTDGKRKGNKKRNEEDKDKTKDHRVCLGEADSQSSVGSSQNLSGRDEVQESQSKETTPRKPCRTHKNKQLSPRVRPVYDGHCPSCQMPFSSLLGQTPRWHVFECLDSPPISDTECPEGLLCTSTIPSHYKKYTHLLLAQSRASNEPSSSPSHMPAGRFTEAKPASSCNLEERWPVHLKAENLRVLDDSLLIQCLKTSALPPETNRKNPPSTNSQMSLVPQCTEPVKKDKLVGGGLPLPEDALSSQSASQGTNLPSPESDCGGCEISYSPLQSDEETYDLDQELDDSQQELFCTQSSKDSSLEDDGSPIFENFHDPFPREPEGVFPTAESLVTRADCNRLCKGSVLSDSFQLLSQTESRLSQDDPPSPDAGFLLFSPASAAGPAASNYQATKAKPGEPEESRSLGSSHQKGKMATSAVGSQIPLPLRASAMSKPMEKEGGEHQPLHPTQSQIGGLRRESLGATIANSACACRKVEKPSIAVLAKSLSPLPSSPKCSASQPSKKVMKQMDIGVFFGLPPKRQEPSLRESVSGEPNVNPVASPNKKRPRPCKRKAENSLSDSELHSGDLNESQHSMEQPGERAQRRRKRHKKSDSPQQRSGHPINNPELGTVSLNKSRAFGRRTHGRPQRGSTGTSKWSGSRELRRACPFYKRIPGTGFTVDAFQYGEVEGCTAYFLTHFHSDHYAGLSKDFERPIYCSEITGNLVKKKLRVQEQYIHQLPMDTECIVDGVKVVLLDANHFSVLLTAPPYCTLETSEPTPAWSAPFSQARKSTHCHWWPLSVSYSCPCHRYCSPEYTFPSQQEVIQFAINTAFEAVTLNPRALVVCGTYCIGKEKVFLAIADVLGSKVGMSQEKYKTLKCLNLPDVNSLITTDMCSSLVHLLPMMQINFKGLQSHLEKCDGKYDQILAFRPTGWTHSNRITSIADITPQKKGKISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGTFKSRDTMEKYFKEWRLEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JJM1</accession>
    <name>A0A9J7JJM1_CRIGR</name>
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        <submittedName>
            <fullName evidence="15">Olfactory receptor 13G1</fullName>
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        <name evidence="15" type="primary">LOC100767735</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
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        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
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            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
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            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
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        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Possible taste receptor.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_027407938.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="100767735"/>
    <dbReference type="KEGG" id="cge:100767735"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
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        <location>
            <begin position="55"/>
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        </location>
    </feature>
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            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
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            <begin position="136"/>
            <end position="155"/>
        </location>
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            <end position="289"/>
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        <location>
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            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053672"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027263739.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34435" checksum="C961C0702B2A87E0" modified="2023-06-28" version="1">MNNSIVREFMILGLTQKSELQGILFIIFLFTYLVAFFGNLLIVIAIIYNTTLHTPMYILLLALAVVDIICTTSIIPKMLGTMLTSENSISYGGCMSQLFFFTWSLGAEMVLFTTMAYDRYVAICFPLRYSTIMNHYTCATMLSIVMGIAVTNSWVHTGLILRLTFCGPNAIDHFFCEIPPLLALSCSPVRVNEVMVYVADITLAVGDFTLTCISYGFIIAAILRIRTTEGKRKAFSTCSSHLMVVALYYSPVIYTYIRPASSYTFERDKVVAALYTLVTPTLNPIVYSFRNKEMQAGIRKVFAFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JNE3</accession>
    <name>A0A9J7JNE3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Olfactory receptor 10G7 isoform X2</fullName>
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    <gene>
        <name evidence="14" type="primary">LOC100758628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027268101.1">
        <property type="nucleotide sequence ID" value="XM_027412300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JNE3"/>
    <dbReference type="GeneID" id="100758628"/>
    <dbReference type="KEGG" id="cge:100758628"/>
    <dbReference type="OrthoDB" id="9045771at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15916">
        <property type="entry name" value="7tmA_OR10G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027268101.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34640" checksum="8C37F162405411C3" modified="2023-06-28" version="1">MSNMSIVTMFFLSGIPHAPSLDTMLFAIFLVIYILTVLGNLLILMVIRVDSHLHTPMYYFLTNLSFIDMWFSTVTVPKMLMTLLSPEGGAISFYSCVAQFYSFHFLGSTECFLYTVMSYDRYLAISYPLRYSSMMSGRVCALLAAGTWLTGSLHSAVQTTLTFHLPYCGPNHIQHYFCDAPPILKLACADTSANEMVIFVNIGVVASGCFVLIALSYVSIVCSILRIRTSEGRHRAFQTCASHCIVVLCFFGPGLFIYLRPGSRDAVDGVVAVFYTVLTPLLNPVVYTLRNKEVKKALLKLKYGSVFTRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JQH6</accession>
    <name>A0A9J7JQH6_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: mastermind-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Maml2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mastermind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027270943.2">
        <property type="nucleotide sequence ID" value="XM_027415142.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JQH6"/>
    <dbReference type="GeneID" id="100762611"/>
    <dbReference type="KEGG" id="cge:100762611"/>
    <dbReference type="CTD" id="84441"/>
    <dbReference type="OrthoDB" id="9908492at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007221">
        <property type="term" value="P:positive regulation of transcription of Notch receptor target"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046369">
        <property type="entry name" value="MAML1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046370">
        <property type="entry name" value="MAML_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019082">
        <property type="entry name" value="Mastermind-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15692">
        <property type="entry name" value="MASTERMIND-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15692:SF9">
        <property type="entry name" value="MASTERMIND-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09596">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01275">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Neurogenic mastermind-like N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="688"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="758"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="965"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="576"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="788"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027270943.2"/>
        </source>
    </evidence>
    <sequence length="1137" mass="122664" checksum="098108CD632A0624" modified="2023-06-28" version="1">MGDTAPPQAPAGGLGGAPGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLNCEGRYERGRAESSDRERESTMQLLSLVQHGQGARKASKHAKAAATTATTTVPPPPPAAPSVASQATATAPPPPPDYHHHHQQHRLTSNDNGGINREQQPPASTPGDQRTSALLALQGSLKRKQIINLPPANSKRPNGFVDSSFLDIKRIRVGENLSTGQGALPVNNGQSHMMPGALTMSQAPLRKTNALPPPAHSPGNTMFNMGLKEVKKEPGETLSCSKHMDDQMTQESAFTNRFGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFSIDLGQQSQQSTPRPPLPMEKIIIKSEYSPGLTQGTSGSPQLRPPSAGPAFSLANSALPTSSPISTVPQSQPQPQTASGANRALPSWQEVSHAQQLKQIAANRQQHARIQQQQQQQQQQQQQQQQQQTPPNWPALPSSSGPSPGAFVQEKIPSPSFGQQPFSPQGSPMPGVAGSSNQSKAVANYTYKASPSAQAGHLDVLLQQKPQDLSRSFINNPHPTLEPRHGNTKPLFHFNSDQANQQMPSLLPSQSKPSLLHYTQQQQQQQQQQQQQGSLAAQQQQQKQQQPQSSLVAQQQQQHQQQGSMAAQQQQPPAQPTQPLSSQPLLRSPLPLQQKIMLQKMQNQSIAGLGYQVTQQHRQDQHTVVGQNTGPSPSPNSCSNPNTASGYMNSQQSLLNQQMMGKKQPLQRPAMEPKQQLLLQQQMLSDSEKTSPQDQINRHLTRPPPDYKDQRRNSSSLQPATQYSGGSSTVNLNSNQALTNPVSTPTILAPNSSLMSTSHGMRMPLLSTAVQNMGVYGNLPCNQPGTYNVTSAMNQLTQQRNTTQLITNQNNPLMPRPSPLGANNGNNVATFGAGSVGSSQQLRPNLAHSLAGMPAQRSSTVMITSNTTATNWASQDVTAKQQEALKSTGVRFPTGTPATYTPNQSLQPGVGSQPFSQRAVAPPNQLTPTVQMRPMNQMNQTLNGQTIAPLRGLNLRPNQMSSQSLSNMNPSGTGLNQPRTGTNQPPSLTPNTFPSSNQSSRAFQGTDHGSDLAFDFLSQQTDSMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JSB5</accession>
    <name>A0A9J7JSB5_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC113836186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_027275364.1">
        <property type="nucleotide sequence ID" value="XM_027419563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JSB5"/>
    <dbReference type="GeneID" id="113836186"/>
    <dbReference type="KEGG" id="cge:113836186"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF85">
        <property type="entry name" value="RIKEN CDNA 1810024B03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="35"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027275364.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="80489" checksum="1610C22EFE7DFF4A" modified="2023-06-28" version="1">MDIANQFTNKSSEKVKRQLDLKASASEEETLSDHYVILRSLGKGNFAEVKLAYHLHTEVQVAVKVLQNGTNNDFSLNTEIDMYKTLNHPYIIKLFHIINTKEYTYIVLEHAARGDLVSYIGRVGCLQEEQAQHIFTQLVCAVHYCHDNGIAHRDIKLDNILLDDKGNIKLCDFGLATRVTPGQGTKGFCGTLEYWAPELFSGKEYDAKAVDIWSLGVVLYTMVTASFPFKAKTFSDMKEAMLDPKYHLPYTLSQNTANITVQLFTVKPEQRPKIFDIRQHQWLKMKEEFGKITPSLEALWNNLNPSIVVAMGRMGYHPKDISACLCEKKFNNIMATYLILYHTSPCDHCKYAAKFLPAHVTMSRADALTNFPTQRGLSELAFPILLEEHQVHDEKGSRKKRMRSLSMRARLCCQQKRNKHPHPAPKLAHKGTYIKSRSLALNSMICHCSSSRSLSSESISSASFLSCETPQEVNTPNNSSDIQSSGSYREVPHIVNTTATYDIHRGSLQTTSKDSFGDVPPEGIPEIQRYSLQETSKNRLDDVLYKGIPEIQMPFLQETSKQSCDNIPTDDISDIQRSFIQETTNNSFEDVPLGDIPEIHRSSLQETYKNIFYDVPPEDIPEIQRPSLPATSKNSFEDVPHRGVTAASESHLSRGWKRVKKRIRNCLGQLCCCVPASKGSHVSQKEEEPVEVESSAVTHMQIHGVPKMHCCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JSR4</accession>
    <name>A0A9J7JSR4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">UPF0538 protein C2orf76 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">C5H2orf76</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4">17A/GY</strain>
            <tissue evidence="3 4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007638383.1">
        <property type="nucleotide sequence ID" value="XM_007640193.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273590.1">
        <property type="nucleotide sequence ID" value="XM_027417789.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273591.1">
        <property type="nucleotide sequence ID" value="XM_027417790.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289930.1">
        <property type="nucleotide sequence ID" value="XM_027434129.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JSR4"/>
    <dbReference type="GeneID" id="100761351"/>
    <dbReference type="KEGG" id="cge:100761351"/>
    <dbReference type="CTD" id="110400635"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027273590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027273591.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16731" checksum="F6808FCED41CB59A" modified="2023-06-28" version="1">MCSEELNSVLTLGQYSLHMAAEEATVTVRLIRSFEHRNFKPVVYHRVNLDQTVKEFIIFLKQDVPLRTSLPPPLRNYKYDTLKILHQAHKAKTNELVLGLEDDDTLLLKEDRTLKDSGIASETEIAFFCEEDYKRYKANPTSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JY08</accession>
    <name>A0A9J7JY08_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Nmt1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70671"/>
            <dbReference type="Rhea" id="RHEA-COMP:17947"/>
            <dbReference type="Rhea" id="RHEA-COMP:17948"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:189855"/>
            <dbReference type="ChEBI" id="CHEBI:189856"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70672"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="11"/>
    <dbReference type="RefSeq" id="XP_027283818.1">
        <property type="nucleotide sequence ID" value="XM_027428017.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JY08"/>
    <dbReference type="GeneID" id="100759338"/>
    <dbReference type="KEGG" id="cge:100759338"/>
    <dbReference type="CTD" id="4836"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF7">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="140"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="307"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027283818.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="56763" checksum="56E99EEC594D2227" modified="2023-06-28" version="1">MADESETAVKLPAPSLPQMMEGNGNGHEHCSDCENEEDNSYNRGGMSPANDTGAKKKKKKQKKKKEKSNDTDAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRAMEKKDIPVVHQLLTRYLKQFLLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JZC7</accession>
    <name>A0A9J7JZC7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SH3 domain-containing protein C23A1.17 isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC103162738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
            <tissue evidence="2">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027288728.1">
        <property type="nucleotide sequence ID" value="XM_027432927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7JZC7"/>
    <dbReference type="GeneID" id="103162738"/>
    <dbReference type="KEGG" id="cge:103162738"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_027288728.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="52835" checksum="BF1F6A2ED4693DBB" modified="2023-06-28" version="1">MFALRPLAFSAFHDSREPHVGALPPLAFSAIHASREPHVGALPPLAFSAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGALPPLAFPAVHASREPHVGAPPPLAFPAVHASREPHVGALPLAFPTVHASREPHVGAPPPLAFSAMDMRLESLMLALRPPRFQCDGHASREPHVGAPPPSLSVRWTCVSRASCWRSAPLAFGAMDMRLESLMLALRPPRFRCDGHASREPHVGAPLPSLFVLYPFFSKMQPTVLFTGTTATSGRHLQRARDRRGQNAAVKFQSATHIDLNLRSLQPQFSQIGLLFITSNVRITSMCSRSQLDTSNNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K1Z1</accession>
    <name>A0A9J7K1Z1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC113838820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative pheromone receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027290139.1">
        <property type="nucleotide sequence ID" value="XM_027434338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K1Z1"/>
    <dbReference type="GeneID" id="113838820"/>
    <dbReference type="KEGG" id="cge:113838820"/>
    <dbReference type="OrthoDB" id="9606139at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016503">
        <property type="term" value="F:pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000033">
        <property type="entry name" value="Vomeronasal type-1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004072">
        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24062">
        <property type="entry name" value="VOMERONASAL TYPE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01534">
        <property type="entry name" value="VOMERONASL1R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027290139.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36094" checksum="BEA2E7F44F647370" modified="2023-06-28" version="1">MLPSNTILGVFLITQLCVGVTGNSLLFIMYIYTFFFKPHFKKLIDSVSMHLTIVNVLMIIFMLISHIMSFFGVCKFLDDAGCRTVLFIFRVSRGMSISTTSILNTFQVITITPSNSRWAWLKPKLSKLTWSSLICSWLINLLIYAYMIPIVIAKTNSTHFGIGYVNPYCQNKHFGEQNSGSFLIVIFIYDFFYVAIMMWTSLYMVTVLYRHRKRVQHLHSTSLSSQPSPERKASHNILLLVICFVFIYWLNNFITLSGVYVQVKIPNWDGINAIVATCYTTICPFLLKNNKLVLHFTSSLPERRMACFQSALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K278</accession>
    <name>A0A9J7K278_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: cullin-4B-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100767300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027288168.2">
        <property type="nucleotide sequence ID" value="XM_027432367.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100767300"/>
    <dbReference type="KEGG" id="cge:100767300"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000003">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000004">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000008">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000059">
        <property type="entry name" value="Cullin-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="9">
        <location>
            <begin position="429"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027288168.2"/>
        </source>
    </evidence>
    <sequence length="615" mass="71162" checksum="E3465595CFA62DA7" modified="2023-06-28" version="1">MAEESSSSSFSSSPTAATSQQQQQQLKNMSILISSVASVHHANRLSKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDKTWKKLKEAVEAIQNSTSIKYNLEELYQVVESLCSYKISANLYKQLRQICEDHIKGQIHQFREDSLNSVLFLKKIDKCWENHCRQMIMIRSIFVCLFLDRTYVLQTSMLHSIWDMGLELCRVHIISDQKVQTKTIDGILLLRERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQLFLEETNWLYAAEGQKLMQEREVPEYLHHINKCLEEEADRLITYLDQTTQKSLIVSVGKQLLGEHLTTILQKGLNNLLYENRIQDLSLLYQLFSRVQGEIQVLLQQWIEYIKAFGSTIVINPEIDNTMVQELLDFKNTVDHIIDTCFLINEKFINAMKEAFETFIDKRPNKPAELIAKYVDXKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKCLLFGKSESVDAEKMLSKLKHECGAAFTGKLEGMFKDMELSKDIMVQFKQYMQNQNVPGNIXLTVNILTMGYWPTCEPMEVHLPPEMVKLQEIFKTFYLGKHSGTKLQWQSTLGHCVLKAEFKEGKNNFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K540</accession>
    <name>A0A9J7K540_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC118238365</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC118238717</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC118238365</name>
        <name evidence="5" type="synonym">LOC118238717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4 5">17A/GY</strain>
            <tissue evidence="4 5">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035296282.1">
        <property type="nucleotide sequence ID" value="XM_035440391.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299989.1">
        <property type="nucleotide sequence ID" value="XM_035444098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K540"/>
    <dbReference type="GeneID" id="118238365"/>
    <dbReference type="KEGG" id="cge:118238365"/>
    <dbReference type="KEGG" id="cge:118238717"/>
    <dbReference type="OrthoDB" id="9626004at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050462">
        <property type="entry name" value="Retroviral_Gag-Pol_poly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33166">
        <property type="entry name" value="GAG_P30 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core shell protein Gag P30" evidence="2">
        <location>
            <begin position="14"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035296282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_035299989.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35889" checksum="92BDD2A2857D8BFB" modified="2023-06-28" version="1">MGEGRYQYWPFSSADLYNWKAHNPPFSQDPQALTGLIESILITHQPTWDDCQQLLRILLTTEERQRVLLEARKNVPGPDGRPTQLPNEIDEVFPLIRPTDWDINTAAGRERHRLYRQTLLAGLKGAGRRPTNLAKVRAVVQGLEETPAGFLERLMEAYRMYTPFDPQAQDREADIIMSFIGQSAPDIRTKLQRLEGLQGYTLRDLVKEAEKIFNKRETPEEKEERLRKLQEDRENVRDKKQNQELAKILATVVQGSEHRPGQTGNLGDKRRTRVERNQCAYCKEKGHWVKHCPKNPRRKPTPILPLEKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7K5H0</accession>
    <name>A0A9J7K5H0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="32">Vesicular glutamate transporter 2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">Slc17a6</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
            <tissue evidence="32">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71255"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>K(+)(in) + H(+)(out) = K(+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>phosphate(in) = phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:32823"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Synapse</location>
            <location evidence="23">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035298385.1">
        <property type="nucleotide sequence ID" value="XM_035442494.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314535.1">
        <property type="nucleotide sequence ID" value="XM_035458644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7K5H0"/>
    <dbReference type="GeneID" id="100773912"/>
    <dbReference type="CTD" id="57084"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140788">
        <property type="term" value="F:L-glutamate uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098700">
        <property type="term" value="P:neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050803">
        <property type="term" value="P:regulation of synapse structure or activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17382">
        <property type="entry name" value="MFS_SLC17A6_7_8_VGluT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000004">
        <property type="entry name" value="vesicular glutamate transporter 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000005">
        <property type="entry name" value="vesicular glutamate transporter 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF201">
        <property type="entry name" value="VESICULAR GLUTAMATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0868">Chloride</keyword>
    <keyword evidence="16" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="7" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="8 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="30">
        <location>
            <begin position="71"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00035839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00038044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_035298385.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="64689" checksum="10B05EEB997E26D5" modified="2023-06-28" version="1">MESVKQRILAPGKEGIKNFAGKSLGQIYRRVLEKKQDTRETIELTEDGKPLEVPEKKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATTQENGGWPNGWEKKEEFVQEGAQDAYTYKDQDDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KDW4</accession>
    <name>A0A9J7KDW4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrin alpha-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Itga7</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Membrane</location>
            <topology evidence="1 20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306529.1">
        <property type="nucleotide sequence ID" value="XM_035450638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KDW4"/>
    <dbReference type="GeneID" id="100773038"/>
    <dbReference type="CTD" id="3679"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000002">
        <property type="entry name" value="integrin alpha-6 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000002">
        <property type="entry name" value="integrin alpha-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1530:FF:000001">
        <property type="entry name" value="Integrin subunit alpha 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF90">
        <property type="entry name" value="INTEGRIN ALPHA-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 20" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 20 26" id="KW-0401">Integrin</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1085"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="19">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="19">
        <location>
            <begin position="350"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="19">
        <location>
            <begin position="412"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="19">
        <location>
            <begin position="471"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="22">
        <location>
            <begin position="515"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="23">
        <location>
            <begin position="683"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="24">
        <location>
            <begin position="853"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1139"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1144"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1159"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_035306529.1"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130005" checksum="AD3BA736AA6D55D6" modified="2023-06-28" version="1">MGRIPSCDSLRPPGIYCLLRYLFAGLLLPWAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDRGANVQKESKENQWLGVSVRSQGPGGKIVTCAHRYESRQRVDQILETRDVIGRCFVLSEDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAATFSPDSHYLVFGAPGTYNWKGTARVELCAQGSSDLAHLDDGPYEAGGEKDQDPSLIPVPANSYFGLLFVTNIDSSDPDQLVYKTLDPADRLTGPAGDLTLNSYLGFSIDSAKGLLRAEELSFVAGAPRANHKGAVVILRKDSASRLIPEVVLSGERLTSGFGYSLAVADLNNDRWPDLIVGAPYFFERQKELGGAVYVYMNQGGRWTHTPPLRICGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGMVVKPSQVLEGEAVSIKSFGYSLSGGLDVDGNYYPDLLVGSLADTAALFRARPVLHVSQEIFIAPRAIDLEQPNCAGGRLVCVDIRICFSYTAVPSSYSPVVALDYTLDGDTDRRLRGQVPRVTFLSRGLDDLKHQSSGTVWLKHQQDRVCGDAMFQLQENVKDKLRAIVVTLQYSLQTPRLRWQRQAPGQGLPPVAPILSAHQPSTQRTEIHFLKQGCGEDKICQSNLQLVQARFCSRISDTEFQPLPMDVDGMTALFALSGQPFIGLELTITNLPSDPARPQADGDDAHEAQLLVTLPTSLHYSGVRALDSAEKPLCLSNENASHVECELGNPMKRGAQVTFYLLLSTSGITIETTELEVELLLATISEQELHPVSVRAQVFIELPLSISGVATPQQLFFSGVVKGESAMRSERDVGSKVKYEITVSNQGQSLNTLGSAFLNIMWPHEIANGKWLLYPMRVELEGGQGPGKKGICSPRPNILRLDVDSRDRRRRELEQPEPQEPPEKLEPSSTSWWPVSSAERKRNVTLDCAQGTAKCVVFSCPLYSFDRVAVLHVWGRLWNSTFLEEYIAVKSLEVIVRANITVKSSIKNLLLRDASTTIPVMVYLDPMAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKLGFFKRAKHPEATVPQYHAVKILREDRQQFKEEKTGTIQRSNWGNSQWEGSDAHPILDADWHPDLGPDGTPVPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7KET3</accession>
    <name>A0A9J7KET3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="5">dUTPase</shortName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC107978202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035307919.1">
        <property type="nucleotide sequence ID" value="XM_035452028.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311236.1">
        <property type="nucleotide sequence ID" value="XM_035455345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7KET3"/>
    <dbReference type="GeneID" id="107978202"/>
    <dbReference type="KEGG" id="cge:107978202"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039915686" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035307919.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20610" checksum="F8D086B9F221ACAB" modified="2023-06-28" version="1">MQSIFTSRPVLLLFCLRNYGWTLCVSPFATMPCLEDAVAGSISMKTWAEDGLSLCFLRLSEHATAPTLGSARAVGYSAYEYTIPPMEKAILKTDIQIAVPSGCYGRVTPWSGLAVKHFTDVGAGVIDEVYRGNVGVGLSNFGKEKFEIKKGDRIAQLICERIFYLNLEEVETMDDTERGSGGFGSTGKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B2ZXD5</accession>
    <name>GPHR_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Golgi pH regulator</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein GPR89</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GPR89</name>
        <name type="synonym">GPHR</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nat. Cell Biol." volume="10" first="1135" last="1145">
            <title>GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.</title>
            <authorList>
                <person name="Maeda Y."/>
                <person name="Ide T."/>
                <person name="Koike M."/>
                <person name="Uchiyama Y."/>
                <person name="Kinoshita T."/>
            </authorList>
            <dbReference type="PubMed" id="18794847"/>
            <dbReference type="DOI" id="10.1038/ncb1773"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 4">Voltage-gated channel that enables the transfer of anions such as iodide, chloride, bromide and fluoride which may function in counter-ion conductance and participates in Golgi acidification (PubMed:18794847). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Homotrimer (By similarity). Interacts with RABL3; the interaction stabilizes GPR89B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Delayed transport of newly synthesized protein from the Golgi to the plasma membrane, impaired glycosylation of proteins along the exocytic pathway, and structural disorganization of the Golgi apparatus. Defects are associated with decreased acidification of the cisternae of the Golgi and trans-Golgi network by 0.4-0.5 pH units with no effect on lysosomal pH and no effect on endocytosis or recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <dbReference type="EMBL" id="AB362891">
        <property type="protein sequence ID" value="BAG41890.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001233742.1">
        <property type="nucleotide sequence ID" value="NM_001246813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B2ZXD5"/>
    <dbReference type="SMR" id="B2ZXD5"/>
    <dbReference type="TCDB" id="1.A.38.1.1">
        <property type="family name" value="the golgi ph regulator (gphr) family"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="B2ZXD5">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-NP_001233742.1"/>
    <dbReference type="GeneID" id="100689387"/>
    <dbReference type="KEGG" id="cge:100689387"/>
    <dbReference type="CTD" id="36682"/>
    <dbReference type="eggNOG" id="KOG2417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030217">
        <property type="term" value="P:T cell differentiation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0407">Ion channel</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0851">Voltage-gated channel</keyword>
    <feature type="chain" id="PRO_0000395005" description="Golgi pH regulator">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0CG08"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q8BS95"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18794847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="455" mass="52738" checksum="8F14ED2211444388" modified="2008-07-22" version="1">MSFLIDSSIMVTSQILFFGFGWLFFMRQLFKDYEVRQYVVQVIFSVTFAFSCTMFELIIFEILGVLNSSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNIQLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAVARRTMFQRGEVQNKPSGLWGMLKSVTASAPGSENLTLIQQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVLDRVGKTDPVTRGIEITVNYLGIQFDVKFWSQHISFILVGIIIVSSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFVSSVLLIRMSMPPEYRTIITQVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPEKHMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3GVW4</accession>
    <name>G3GVW4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17 21 22">Zinc finger protein 133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 21 22 23 24" type="primary">Znf133</name>
        <name evidence="17" type="ORF">I79_001867</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21 22 23">17A/GY</strain>
            <tissue evidence="21 22 23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
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        <property type="protein sequence ID" value="EGV95401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648592.1">
        <property type="nucleotide sequence ID" value="XM_007650402.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007648598.1">
        <property type="nucleotide sequence ID" value="XM_007650408.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277423.1">
        <property type="nucleotide sequence ID" value="XM_027421622.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277424.1">
        <property type="nucleotide sequence ID" value="XM_027421623.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277425.1">
        <property type="nucleotide sequence ID" value="XM_027421624.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027297865.1">
        <property type="nucleotide sequence ID" value="XM_027442064.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302591.1">
        <property type="nucleotide sequence ID" value="XM_035446700.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035317072.1">
        <property type="nucleotide sequence ID" value="XM_035461181.1"/>
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    <dbReference type="STRING" id="10029.G3GVW4"/>
    <dbReference type="PaxDb" id="10029-XP_007630510.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001014265.1">
        <property type="protein sequence ID" value="ENSCGRP00001010045.1"/>
        <property type="gene ID" value="ENSCGRG00001012031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767427"/>
    <dbReference type="KEGG" id="cge:100767427"/>
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    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="QKFHMQH"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000155">
        <property type="entry name" value="zinc finger protein 133 isoform X1"/>
        <property type="match status" value="2"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000189">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000740">
        <property type="entry name" value="zinc finger protein 133 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:001070">
        <property type="entry name" value="zinc finger protein 133 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001353">
        <property type="entry name" value="zinc finger protein 133 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:001393">
        <property type="entry name" value="zinc finger protein 133 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger protein 133 isoform X2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01352">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="15"/>
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        <property type="match status" value="8"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="326"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50805"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV95401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010045.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027277424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027277425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035302591.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="73804" checksum="4B53B8D45767F4D6" modified="2011-11-16" version="1">MAFRDVAVDFSQEEWSLLSPAQRSLYREVMLENYSNLVSLGIPFSKPKLITQLEQGKETWQEERKCPQVACQAQAKLELCPSPVCPPDPTNQKLPGQHGLSDRTPWIFTCLCAKHHVDEGDSCHGAQEEQQQASNRNSCRDKPEGGEREGARPSSRRIKKRSLGALSRAPQRQPVSSRNGISRVGMEASPAQAGSTEEPEKLLKQIEFLGFGTVNCGECGLGFRKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSEEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYTCSECGRGFSQKSNLIIHRRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKSIVCSDCGLGFSDRSNLISHQRTHSGAKPYACKECGQCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPFVCGVCGRRFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCEECGRGFSQKSNLIAHQRIHSGEKPYVCRDCGRGFSHQAGLIRHKRKHSREKPYVCRQCGLGFTNKPALITHKRAHFEERLCVCGECGQSFIHKSHLALHQTTHQREKTYTCRTCGQGFRQRSHLSRHRKKKCAHHKLPLQPDPEACLGQSSDPFYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3GYI7</accession>
    <name>G3GYI7_CRIGR</name>
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        <recommendedName>
            <fullName evidence="31">Activating molecule in BECN1-regulated autophagy protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37 38" type="primary">Ambra1</name>
        <name evidence="34" type="ORF">I79_002866</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="36">17A/GY</strain>
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    <reference evidence="36" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
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            <strain evidence="36">17A/GY</strain>
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                <consortium name="RefSeq"/>
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        <subcellularLocation>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00061691"/>
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    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00074540"/>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="XP_027278298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="RefSeq" id="XP_027278299.1"/>
        </source>
    </evidence>
    <sequence length="1300" mass="142951" checksum="B35D15612997A5CF" modified="2011-11-16" version="1">MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGVNGSSQNNSGNIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSARSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGTASSGPGEGEGSEYAGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLLSEPGQLAERGLSPRTASWDQPSTSGREPPQPAPPSSSSAPIPVPLASNEGPTMHCNVTNNSHLPEGDGNSRGEAAGPSGEPRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3GZJ6</accession>
    <name>G3GZJ6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vesicle-associated membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20 21 22 23 24" type="primary">Vamp4</name>
        <name evidence="16" type="ORF">I79_003268</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21 22" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21 22">17A/GY</strain>
            <tissue evidence="20 21 22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. Interacts with BAIAP3; this interaction is increased in the presence of calcium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000079">
        <property type="protein sequence ID" value="EGV93276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003497700.1">
        <property type="nucleotide sequence ID" value="XM_003497652.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007613476.1">
        <property type="nucleotide sequence ID" value="XM_007615286.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007613488.1">
        <property type="nucleotide sequence ID" value="XM_007615298.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007613493.1">
        <property type="nucleotide sequence ID" value="XM_007615303.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273014.1">
        <property type="nucleotide sequence ID" value="XM_027417213.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273015.1">
        <property type="nucleotide sequence ID" value="XM_027417214.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273016.1">
        <property type="nucleotide sequence ID" value="XM_027417215.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273017.1">
        <property type="nucleotide sequence ID" value="XM_027417216.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273018.1">
        <property type="nucleotide sequence ID" value="XM_027417217.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3GZJ6"/>
    <dbReference type="STRING" id="10029.G3GZJ6"/>
    <dbReference type="PaxDb" id="10029-XP_007628139.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001028108.1">
        <property type="protein sequence ID" value="ENSCGRP00001023862.1"/>
        <property type="gene ID" value="ENSCGRG00001021945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771557"/>
    <dbReference type="KEGG" id="cge:100771557"/>
    <dbReference type="CTD" id="8674"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155005"/>
    <dbReference type="OMA" id="NHDKASN"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090161">
        <property type="term" value="P:Golgi ribbon formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098876">
        <property type="term" value="P:vesicle-mediated transport to the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15869">
        <property type="entry name" value="R-SNARE_VAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000050">
        <property type="entry name" value="Vesicle-associated membrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042887">
        <property type="entry name" value="VAMP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46897">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46897:SF1">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV93276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027273014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027273015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027273016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_027273017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027273018.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16320" checksum="556CC138213CF91E" modified="2011-11-16" version="1">MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALAAAILLLMIIILIVVKNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3H0V0</accession>
    <name>G3H0V0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="15">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 22 23 24 25 26 27 28" type="primary">Ppip5k1</name>
        <name evidence="18" type="ORF">I79_003769</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22 23 24" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22 23 24">17A/GY</strain>
            <tissue evidence="22 23 24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
            <location evidence="2 15">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="15"/>
    <dbReference type="EMBL" id="JH000098">
        <property type="protein sequence ID" value="EGV97210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027261467.1">
        <property type="nucleotide sequence ID" value="XM_027405666.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277848.1">
        <property type="nucleotide sequence ID" value="XM_027422047.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300612.1">
        <property type="nucleotide sequence ID" value="XM_035444721.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035300619.1">
        <property type="nucleotide sequence ID" value="XM_035444728.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302786.1">
        <property type="nucleotide sequence ID" value="XM_035446895.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302787.1">
        <property type="nucleotide sequence ID" value="XM_035446896.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302788.1">
        <property type="nucleotide sequence ID" value="XM_035446897.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302789.1">
        <property type="nucleotide sequence ID" value="XM_035446898.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302790.1">
        <property type="nucleotide sequence ID" value="XM_035446899.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035302791.1">
        <property type="nucleotide sequence ID" value="XM_035446900.1"/>
    </dbReference>
    <dbReference type="STRING" id="10029.G3H0V0"/>
    <dbReference type="PaxDb" id="10029-XP_007621691.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023558.1">
        <property type="protein sequence ID" value="ENSCGRP00001019314.1"/>
        <property type="gene ID" value="ENSCGRG00001018749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767441"/>
    <dbReference type="KEGG" id="cge:100767441"/>
    <dbReference type="CTD" id="9677"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000001">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF11">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="916"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1180"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1459"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1213"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1483"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV97210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027277848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035302786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035302787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035302788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_035302789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_035302790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_035302791.1"/>
        </source>
    </evidence>
    <sequence length="1510" mass="167860" checksum="979EBB5588210B4A" modified="2011-11-16" version="1">MWSLTANEDENTTAHFFLGAGDEGLGTCEIGMRMEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHSRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGIEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDPQREALAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFSLIENLTRQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLHLSKALADVVIPQEYGISREEKMEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGIEEGSAPAGCGFRPASSENEEMKPDQGSIENLCPGKASDEPDRALQTSPQPIEGTGLPRRSPLIRNRKAGSMEVMNMQCTGNLDLIPLRGRRRRRSGDLPRLSPAIGLQPRAVSTTHLASCTQVLSETSSSRPGGYRLFSSSRQPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHSNQASDSPFSPPRALHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTAVDGNSHFGFSDQSSVNTHVTEENQGLGLLQEVPGDGIQEFPIERQQELIEPNQSPQEPPVEISALGQDVAEVSQTCHDILEKVSQPNQEVPDISQLFLKNHDTATNTCQPCQKASQLSQEVFQLCQDNPEESNQVCQEVPVELGRMAHGFSVNIDSMVQETFIETGRPTQEISEEMGPPFQEFPVEVGMLAQEVPANIELSQDILEADSPSQELTAVEAGLQAQEISEEIDQDSKVVPEVVDELPSEDVPQGQCLSSDVNTESQSLAHDQHSSLPPAMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3H3L4</accession>
    <name>G3H3L4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="14">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">LOC100752211</name>
        <name evidence="16" type="ORF">I79_004802</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="14"/>
    <dbReference type="EMBL" id="JH000127">
        <property type="protein sequence ID" value="EGW02154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003498894.1">
        <property type="nucleotide sequence ID" value="XM_003498846.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273355.1">
        <property type="nucleotide sequence ID" value="XM_027417554.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3H3L4"/>
    <dbReference type="STRING" id="10029.G3H3L4"/>
    <dbReference type="PaxDb" id="10029-XP_007633914.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031787.1">
        <property type="protein sequence ID" value="ENSCGRP00001027540.1"/>
        <property type="gene ID" value="ENSCGRG00001024525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752211"/>
    <dbReference type="KEGG" id="cge:100752211"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160784"/>
    <dbReference type="OMA" id="CLDPENW"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF74">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="44"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGW02154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027273355.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34207" checksum="AFE57D7FB0C8942D" modified="2011-11-16" version="1">MGIQPSPVLLASLGVGLLTLLGLAVATYLVRRSRRSQVTLRDPDEKYLLRLLDKTTVSQNTKRFRFALPTANHILGLPVGKHVYLSARIDGNLVIRPYTPVTSDEDRGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKIGDVVEFRGPSGLLNYAGKGNFYIQTNKNSPSELRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQAQYPNRFKLWFTLDHPPEGWTYSRGFVTADMIQQHLPPPADDVLVLLCGPPPMVQLACHPNLDKLCYSQKMRFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3HAR3</accession>
    <name>G3HAR3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA-binding protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA-binding motif protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC100756430</name>
        <name evidence="11" type="ORF">I79_007521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15">17A/GY</strain>
            <tissue evidence="14 15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH000254">
        <property type="protein sequence ID" value="EGW02781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640032.1">
        <property type="nucleotide sequence ID" value="XM_007641842.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640033.1">
        <property type="nucleotide sequence ID" value="XM_007641843.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277139.1">
        <property type="nucleotide sequence ID" value="XM_027421338.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027277140.1">
        <property type="nucleotide sequence ID" value="XM_027421339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HAR3"/>
    <dbReference type="STRING" id="10029.G3HAR3"/>
    <dbReference type="PaxDb" id="10029-XP_007616722.1"/>
    <dbReference type="GeneID" id="100756430"/>
    <dbReference type="KEGG" id="cge:100756430"/>
    <dbReference type="eggNOG" id="KOG1327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HAR3"/>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12745">
        <property type="entry name" value="RRM1_RBM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12747">
        <property type="entry name" value="RRM2_RBM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12512">
        <property type="entry name" value="RRM3_RBM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12749">
        <property type="entry name" value="RRM4_RBM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12751">
        <property type="entry name" value="RRM5_RBM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000193">
        <property type="entry name" value="RNA-binding motif protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000228">
        <property type="entry name" value="RNA-binding motif protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000303">
        <property type="entry name" value="RNA-binding motif protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000307">
        <property type="entry name" value="RNA-binding motif protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034591">
        <property type="entry name" value="RBM12_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034594">
        <property type="entry name" value="RBM12_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034855">
        <property type="entry name" value="RBM12_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034856">
        <property type="entry name" value="RBM12_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034854">
        <property type="entry name" value="RBM12_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="304"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="430"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="921"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="863"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGW02781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027277139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027277140.1"/>
        </source>
    </evidence>
    <sequence length="997" mass="103122" checksum="13274F7C2778CCE8" modified="2011-11-16" version="1">MAVVIRLQGLPIVAGTMDIRHFFSGLTIPDGGVHIVGGELGEAFIVFATDEDARLGMMRTGGTIKGSKVTLLLSSKTEMQNMIELSRRRFETANLDIPPANASRSGPPPSSGMSNRVNLPATVPNFNNPSPSVVTATTSVHESNKNIQTFSTASVGSAPPSMGTSFGSPTFSSTIPSTASPMNTVPPPPIPPIPAMPSLPPLPSIPPIPVPPPVPTLPPVPPVPPIPPVPNVPPMTPLPPMSGMPPLNPPPVAPLPAGMNGSGAPMSLNNNLNPVFLGPLTPVNPIQMNSQSSVKSLPVNPDDLYVSVHGMPFSAMENDVREFFHGLRVDAVHLLKDHVGRNNGNGLVKFLSPQDTFEALKRNRMLMIQRYVEVSPATERQWVAAGGHITFKQSMGPSGQAHPPPQTLPRSKSPSGQKRSRSRSPHEAGYCVYLKGLPFEAENKHVIDFFKKLDIVEDSIYIAYGPNGKATGEGFVEFRNDADYKAALCRHKQYMGNRFIQVHPITKKGMLEKIDMIRKRLQNFSYDQREMVLNPEGDVSSAKVCAHITNIPFSITKMDVLQFLEGIPVDESAVHVLVDNNGQGLGQALVQFKTEDDARKSEHLHRKKLNGREAFVHIVTLEDMREIEKNPPAQGKKGLKIPVPGNPAVPVMPSAGMPAAGIPAAGIPGSGMPGAGMPGAGMPSAGMPAAGMPGAGMPSAGMPGAGIPGAGMPGAGIPGAGIPGPAMPGPAIPGPAMPGPAMPGPAIPGAAIPGPAIPGPALPGAGIPTAGGEEHVFLTVGSKEANNGPPFNFPGNFGGPNAFGPPLPPPGLGGAFGDVRPVMPSVGNSGLPGLGLEVPGFGGAPNNLSGPSGFGGIPQNFGNGPGSLNAPPGFGSGPPSLGSVPGHLSGPPAFGPGPGPGPIHIAGPPGFGASSGKPGPTIIKVQNMPFTVSIDEILDFFYGYQVIPGSVCLKYNEKGMPTGEAMVAFESRDEATAAVIDLNDRPIGSRKVKLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3HAY8</accession>
    <name>G3HAY8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-related protein Rab-7b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15 16 17" type="primary">Rab7b</name>
        <name evidence="11" type="ORF">I79_007600</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15 16 17">17A/GY</strain>
            <tissue evidence="15 16 17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000259">
        <property type="protein sequence ID" value="EGV92813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003501258.1">
        <property type="nucleotide sequence ID" value="XM_003501210.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007640091.1">
        <property type="nucleotide sequence ID" value="XM_007641901.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273461.1">
        <property type="nucleotide sequence ID" value="XM_027417660.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273462.1">
        <property type="nucleotide sequence ID" value="XM_027417661.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027273463.1">
        <property type="nucleotide sequence ID" value="XM_027417662.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HAY8"/>
    <dbReference type="STRING" id="10029.G3HAY8"/>
    <dbReference type="PaxDb" id="10029-XP_007609137.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027605.1">
        <property type="protein sequence ID" value="ENSCGRP00001023359.1"/>
        <property type="gene ID" value="ENSCGRG00001021618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756922"/>
    <dbReference type="KEGG" id="cge:100756922"/>
    <dbReference type="CTD" id="338382"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161943"/>
    <dbReference type="OMA" id="MQIWDTG"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034144">
        <property type="term" value="P:negative regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034164">
        <property type="term" value="P:negative regulation of toll-like receptor 9 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000751">
        <property type="entry name" value="Rab family GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF22">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV92813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027273461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027273462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027273463.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22422" checksum="7848C590F66C92DE" modified="2011-11-16" version="1">MNPRKKVDLKLIIVGALGVGKTSLLHQYVHKTFFEEYQTTLGASILSKIIILDDTTLKLQIWDTGGQERFRSVVSTFYKGSDGCILAFDVTDPESFEALGIWRDDVLAKIIPMEQSYPMVVLGNKIDLEDRKVPQEVAHGWCKEKDMPYFEVSAKNDINVVQAFEVLASRALLRYQGTVENHLVESIKLSPGQPKSRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3HEQ2</accession>
    <name>G3HEQ2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA (uracil-5-)-methyltransferase homolog A</fullName>
            <ecNumber evidence="11">2.1.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">mRNA (uracil-5-)-methyltransferase TRMT2A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">Trmt2a</name>
        <name evidence="22" type="ORF">H671_4g12086</name>
        <name evidence="21" type="ORF">I79_009044</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26">17A/GY</strain>
            <tissue evidence="26">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs. Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs. Also able to mediate the formation of 5-methyl-uridine in some mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a uridine in mRNA + S-adenosyl-L-methionine = a 5-methyluridine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69863"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:69864"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="11"/>
    <dbReference type="EMBL" id="JH000319">
        <property type="protein sequence ID" value="EGV97600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE674822">
        <property type="protein sequence ID" value="ERE76112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502501.1">
        <property type="nucleotide sequence ID" value="XM_003502453.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268944.1">
        <property type="nucleotide sequence ID" value="XM_027413143.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HEQ2"/>
    <dbReference type="STRING" id="10029.G3HEQ2"/>
    <dbReference type="PaxDb" id="10029-XP_007616310.1"/>
    <dbReference type="GeneID" id="100774876"/>
    <dbReference type="KEGG" id="cge:100774876"/>
    <dbReference type="CTD" id="27037"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TPLWNMP"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12439">
        <property type="entry name" value="RRM_TRMT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1070:FF:000005">
        <property type="entry name" value="tRNA (Uracil-5-)-methyltransferase homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034262">
        <property type="entry name" value="TRMT2A_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 18 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="74"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV97600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ERE76112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_027268944.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="69364" checksum="AA968B6A04658756" modified="2011-11-16" version="1">MSEKPDTEVKQRERDAEDVNLAREHMEGCGPDASAVHSPAVPERQEQSGPAAGPATQPGLYSYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQSHKIKLFGQPPCAFVTFRSAAERDKALRVLHGALWKGRPLSVRLARPKADPMARKRRQEGDGEPSVTQIADVVTPLWTVPYSEQLEQKRQECERVLQKLAKEIGSTNRALLPWLLTQRQRHNKACCPLEGVRPSPQQTEYRNKCEFLVGVGIDGEDNTVGCRFGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTPYLAYDPETYTGHWKQLTVRTSRRGQAMAIVYFHPQKLSSEEMAGLKASLVYHFMEGPGKASGVTCLYFVEEGQRKTPSQEGLPLEHMAGDQCIQEDLLGLTFRISPHAFFQVNTPAAEVLYTVIQEWAQLDGSSTVLDVCCGTGTIGLALARKVKRVVGIELCQEAVEDARVNALTNELSNVEFHCGRAEDLVPGLVSRLSSQQLVAILDPPRAGLHSKVILAIRRAENIKRLLYVSCNPRAAMGNFVDLCRAPSNRVKGIPFHPVKAVAVDLFPQTPHCEMLILFERMEQHPNGIGTLGHQDSPTTRDLLDSTPLETETALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3HFH7</accession>
    <name>G3HFH7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cilia- and flagella-associated protein 57</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Cfap57</name>
        <name evidence="17" type="ORF">I79_009317</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Associates with components of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility, and might act as an inner dynein arm (IDA) hub or linkage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">May form homodimers. Associates with components of the nexin-dynein regulatory complex (N-DRC) and the CFAP184:CFAP263 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CFAP57 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000327">
        <property type="protein sequence ID" value="EGW08128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003502703.1">
        <property type="nucleotide sequence ID" value="XM_003502655.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027254876.1">
        <property type="nucleotide sequence ID" value="XM_027399075.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HFH7"/>
    <dbReference type="STRING" id="10029.G3HFH7"/>
    <dbReference type="PaxDb" id="10029-XP_007617358.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001019520.1">
        <property type="protein sequence ID" value="ENSCGRP00001015280.1"/>
        <property type="gene ID" value="ENSCGRG00001015909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769099"/>
    <dbReference type="KEGG" id="cge:100769099"/>
    <dbReference type="CTD" id="149465"/>
    <dbReference type="eggNOG" id="ENOG502QTIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00620000088018"/>
    <dbReference type="OMA" id="FPHCNAV"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120316">
        <property type="term" value="P:sperm flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1490:FF:000014">
        <property type="entry name" value="AGAP008095-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000357">
        <property type="entry name" value="Cilia and flagella associated protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000271">
        <property type="entry name" value="cilia- and flagella-associated protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="21" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="21" id="KW-0282">Flagellum</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="16">
        <location>
            <begin position="393"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="795"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1098"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW08128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001015280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027254876.1"/>
        </source>
    </evidence>
    <sequence length="1250" mass="145256" checksum="870314A9DDFC76C2" modified="2011-11-16" version="1">MSTVVAQALHVFGLRSYVANNVFFFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSDKSQGMLALAISPNRRYLAISETVLERPTITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYLLTQTSPPESNLVYWLWEKQKVMAMIRSDVQNNPIYQVSINPQDNTQVCVTGSGVFKLLRFTEGTLKQTNFQRGESPNYLAHSWVSDDRLIVGTDTGKLFLFESGDQRWETSIMVKEPTSSRSLEIIHESESLIEFPQPSSPVPSFEQIVATTYPSHMTMPQVFAIAAYSKGFACSAGPGRVLLFEKATEEKDFYRESREIRIPTDPQSNDPSQSDKQDVLCLCFSPSEETLIASTSKNQLYTITMSLTEISKGEPAHFEYLMYPLHSASITGLSTCIRKPLIATCSLDHSIRIWNYESNTLELFKEYQEEAYTITLHPSGHFIVVGFADKLRLMNLLIDDIRAFKEYSVRGCKECSFSNGGHLFAAVNGNVIHIFTTTSLENVGNLKGHTGKIRSIAWNFDDSRLISAGTDGAVYEWNLSTGKRETECVLKSCSYNSVAVSPDAKIIFAVGSDQTLKEISDSLILREISAFDVVYTAITISHSGRMMFVGTSVGTIRAMKYPLPLQKEFNEYQAHAGPINKMMLTFDDQYLLTVADDGCLFTWRVFDKDGRGIKREREVGFAEEVLVTKTDMEEKAQVMLELKTRVEELKMENEYQLRLKDMNYSEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDIFHRERIEDLMEKQGRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTSLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYEKKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIENLKAEQMKLQGVIKSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNISELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPRLLKEKIRDLFEKYVQRADMVEIAGLNSDLQQEYARQREHLERNLATLKKKVVKEGELHRAGYVRIMQENVSLIKEINELRRELKLTRSQIYDLESALKLSKKLRAQDVPETVVSKDIPSVSTTMRLNEKEETGRIIEMQRLEIRRLRDQIQEQEQVPGFHTIAGVRLPSIVESEVDLEVHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3HFN4</accession>
    <name>G3HFN4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10 11 12">Mpv17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">Mpv17l</name>
        <name evidence="7" type="ORF">I79_009397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10 11 12">17A/GY</strain>
            <tissue evidence="10 11 12">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000332">
        <property type="protein sequence ID" value="EGV93000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243712.1">
        <property type="nucleotide sequence ID" value="XM_027387911.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027243713.1">
        <property type="nucleotide sequence ID" value="XM_027387912.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035308661.1">
        <property type="nucleotide sequence ID" value="XM_035452770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HFN4"/>
    <dbReference type="STRING" id="10029.G3HFN4"/>
    <dbReference type="PaxDb" id="10029-XP_007637340.1"/>
    <dbReference type="GeneID" id="100751270"/>
    <dbReference type="CTD" id="255027"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="G3HFN4"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF39">
        <property type="entry name" value="MPV17-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV93000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027243712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027243713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_035308661.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10536" checksum="BC4DB8BE1F437B1B" modified="2011-11-16" version="1">MSILHGKDDIFLDLKQKFWNTYKSGLMYWPFVQLTNFSLVPVHWRTAYTGLCGFLWATFLCFSQQSGDGTVKSMFIFFLRKEAGDRPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3HMJ8</accession>
    <name>G3HMJ8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC100771117</name>
        <name evidence="16" type="ORF">H671_xg20344</name>
        <name evidence="15" type="ORF">I79_011961</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the large ribosomal subunit. Homodimer. Interacts with DHX33.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000515">
        <property type="protein sequence ID" value="EGV96038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE685033">
        <property type="protein sequence ID" value="ERE65308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003504895.1">
        <property type="nucleotide sequence ID" value="XM_003504847.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027288908.1">
        <property type="nucleotide sequence ID" value="XM_027433107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HMJ8"/>
    <dbReference type="STRING" id="10029.G3HMJ8"/>
    <dbReference type="PaxDb" id="10029-XP_007612574.1"/>
    <dbReference type="GeneID" id="100771117"/>
    <dbReference type="KEGG" id="cge:100771117"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 15 20" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="14">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="13">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV96038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ERE65308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027288908.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29237" checksum="1BED8B7F4C5A58B7" modified="2011-11-16" version="1">MEEAVPEKKKKVPSVPETLKKKQRNFAELKVKRFRKNFALKTLRKPWRKLIYGKAKHYHKENRQMYRTEIRMTRMARKAGNPYVPVEPKLAFVIRIRGINGVSPKVPKMLQLLCLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNKLIYKRGYGKINKKRIALTDNSLIARSLGKYGIICMEDLIHEIYTVEKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINKLIRWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3HPZ0</accession>
    <name>G3HPZ0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Vesicle-associated membrane protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Endobrevin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 31" type="primary">Vamp8</name>
        <name evidence="27" type="ORF">I79_012876</name>
    </gene>
    <organism evidence="27 29">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="30" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
            <tissue evidence="31">Liver</tissue>
        </source>
    </reference>
    <reference evidence="28" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome. Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B. Interacts with PICALM. SNARE complex formation and binding by PICALM are mutually exclusive processes for VAMP8. Interacts with SBF2/MTMR13. Interacts with RAB21 (in GTP-bound form) in response to starvation; the interaction probably regulates VAMP8 endolysosomal trafficking. Interacts with STX17; this interaction is increased in the absence of TMEM39A. Interacts with TRIM6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Early endosome membrane</location>
            <topology evidence="17">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Late endosome membrane</location>
            <topology evidence="18">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Lysosome membrane</location>
            <topology evidence="19">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Zymogen granule membrane</location>
            <topology evidence="16">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="JH000593">
        <property type="protein sequence ID" value="EGV93193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003505678.1">
        <property type="nucleotide sequence ID" value="XM_003505630.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027285288.1">
        <property type="nucleotide sequence ID" value="XM_027429487.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3HPZ0"/>
    <dbReference type="STRING" id="10029.G3HPZ0"/>
    <dbReference type="PaxDb" id="10029-XP_007625491.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017887.1">
        <property type="protein sequence ID" value="ENSCGRP00001013650.1"/>
        <property type="gene ID" value="ENSCGRG00001014727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100774199"/>
    <dbReference type="KEGG" id="cge:100774199"/>
    <dbReference type="CTD" id="8673"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160325"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035577">
        <property type="term" value="C:azurophil granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098594">
        <property type="term" value="C:mucin granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042589">
        <property type="term" value="C:zymogen granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019869">
        <property type="term" value="F:chloride channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016240">
        <property type="term" value="P:autophagosome membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070254">
        <property type="term" value="P:mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903531">
        <property type="term" value="P:negative regulation of secretion by cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903595">
        <property type="term" value="P:positive regulation of histamine secretion by mast cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:symbiont entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15868">
        <property type="entry name" value="R-SNARE_VAMP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000055">
        <property type="entry name" value="vesicle-associated membrane protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="26">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00056220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EGV93193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_027285288.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11425" checksum="F78FA1D77040BA72" modified="2011-11-16" version="1">MEEASGGAGNDRVRNLQSEVEGVKNIMTQNVERILARGENLDHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVIICVIVFVIIILIVLFATGTIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3I3E0</accession>
    <name>G3I3E0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 593</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Zinc finger protein T86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Znf593</name>
        <name evidence="17" type="ORF">I79_017945</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with pre-60S ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001182">
        <property type="protein sequence ID" value="EGW10195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003509785.1">
        <property type="nucleotide sequence ID" value="XM_003509737.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255429.1">
        <property type="nucleotide sequence ID" value="XM_027399628.2"/>
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    <dbReference type="AlphaFoldDB" id="G3I3E0"/>
    <dbReference type="STRING" id="10029.G3I3E0"/>
    <dbReference type="PaxDb" id="10029-XP_007625414.1"/>
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        <property type="protein sequence ID" value="ENSCGRP00001008381.1"/>
        <property type="gene ID" value="ENSCGRG00001010679.1"/>
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    <dbReference type="GeneID" id="100769424"/>
    <dbReference type="KEGG" id="cge:100769424"/>
    <dbReference type="CTD" id="51042"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004173"/>
    <dbReference type="OMA" id="MKDHFRS"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
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    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056372"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068618"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00079254"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGW10195.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008381.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001075"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027255429.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15247" checksum="7C7CAFAB8F17DFF2" modified="2011-11-16" version="1">MGRSRRTGAHRAHSLARQMKAKKRRPDLDEIHRELRPQGLPRPKPELDAEPDPDLPGGGRHRCLACARYFIDSANLKTHFRSKDHKKRLKQLTIEPYSQEEAERAAGMGSYVPPQRLSVPTEVSTEIPEMDTST</sequence>
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<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3I3W9</accession>
    <name>G3I3W9_CRIGR</name>
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        <submittedName>
            <fullName evidence="11">Achaete-scute homolog 3</fullName>
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        <submittedName>
            <fullName evidence="7">Achaete-scute-like 3</fullName>
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        <name evidence="8 11" type="primary">Ascl3</name>
        <name evidence="7" type="ORF">I79_018140</name>
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    <organism evidence="7 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/nbt.1932"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CHO K1 cell line</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="JH001216">
        <property type="protein sequence ID" value="EGW05683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_003509905.4"/>
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    <dbReference type="RefSeq" id="XP_027266143.1">
        <property type="nucleotide sequence ID" value="XM_027410342.2"/>
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    <dbReference type="AlphaFoldDB" id="G3I3W9"/>
    <dbReference type="STRING" id="10029.G3I3W9"/>
    <dbReference type="PaxDb" id="10029-XP_007614591.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003642.1">
        <property type="protein sequence ID" value="ENSCGRP00001002676.1"/>
        <property type="gene ID" value="ENSCGRG00001003029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751483"/>
    <dbReference type="KEGG" id="cge:100751483"/>
    <dbReference type="CTD" id="56676"/>
    <dbReference type="eggNOG" id="KOG4029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162850"/>
    <dbReference type="OMA" id="MMDNRSY"/>
    <dbReference type="OrthoDB" id="6241467at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007431">
        <property type="term" value="P:salivary gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070654">
        <property type="term" value="P:sensory epithelium regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="bHLH_TS_ASCL3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="achaete-scute homolog 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGW05683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027266143.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20332" checksum="2DEA701900DD8109" modified="2011-11-16" version="1">MDSRSYSSPPDRLSVFSESAHLPPSRPFYLDPMVTVHLCPETPVPSPYTEELPLLPFSSDTLIMDNYGDPYPFPFPMPYVNYRRCDYAYGPAFIRKRNERERQRVKCVNEGYARLRRHLPENYLEKRLSKVETLRAAIKYISYLQSLLYPDETEAERNPRTTSCGPLDPSFRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G3I4G0</accession>
    <name>G3I4G0_CRIGR</name>
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        <submittedName>
            <fullName evidence="14 18">EH domain-containing protein 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">EH-domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Ehd3</name>
        <name evidence="14" type="ORF">I79_018338</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JH001249">
        <property type="protein sequence ID" value="EGW09292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003510133.1">
        <property type="nucleotide sequence ID" value="XM_003510085.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027281904.1">
        <property type="nucleotide sequence ID" value="XM_027426103.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I4G0"/>
    <dbReference type="SMR" id="G3I4G0"/>
    <dbReference type="STRING" id="10029.G3I4G0"/>
    <dbReference type="PaxDb" id="10029-XP_007633048.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001026682.1">
        <property type="protein sequence ID" value="ENSCGRP00001022437.1"/>
        <property type="gene ID" value="ENSCGRG00001020979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766335"/>
    <dbReference type="KEGG" id="cge:100766335"/>
    <dbReference type="CTD" id="30845"/>
    <dbReference type="eggNOG" id="KOG1954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159274"/>
    <dbReference type="OMA" id="LMIGQYS"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020018">
        <property type="term" value="C:ciliary pocket membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090160">
        <property type="term" value="P:Golgi to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903779">
        <property type="term" value="P:regulation of cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086036">
        <property type="term" value="P:regulation of cardiac muscle cell membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055117">
        <property type="term" value="P:regulation of cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF67">
        <property type="entry name" value="EH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="55"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="444"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="476"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW09292.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022437.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027281904.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60915" checksum="8719D66A0EB5CE61" modified="2011-11-16" version="1">MFSWLGNDDRRRKDPEVFQTVSEGLKKLYKTKLLPLEEYYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDVEGIIPGNALVVDPKKPFRKLNAFGNAFLNRFVCAQLPNAVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPSVFGKDTKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQDQLQAQDFSKFQPLKNKLLEVVDDMLAHDIAQLMVLVRQEETQRPVQMVKGGAFEGTLQGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFFTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDEEFALANHLIKVKLEGHELPNELPAHLIPPSKRKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3I7N9</accession>
    <name>G3I7N9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">Rab38</name>
        <name evidence="9" type="ORF">H671_3g10099</name>
        <name evidence="8" type="ORF">I79_019535</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Lipid-anchor</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001445">
        <property type="protein sequence ID" value="EGW06790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE672999">
        <property type="protein sequence ID" value="ERE78775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511128.1">
        <property type="nucleotide sequence ID" value="XM_003511080.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027263394.1">
        <property type="nucleotide sequence ID" value="XM_027407593.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I7N9"/>
    <dbReference type="STRING" id="10029.G3I7N9"/>
    <dbReference type="PaxDb" id="10029-XP_007626677.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001018077.1">
        <property type="protein sequence ID" value="ENSCGRP00001013840.1"/>
        <property type="gene ID" value="ENSCGRG00001014873.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768866"/>
    <dbReference type="KEGG" id="cge:100768866"/>
    <dbReference type="CTD" id="23682"/>
    <dbReference type="eggNOG" id="KOG4423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157301"/>
    <dbReference type="OMA" id="MHYKSTI"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035650">
        <property type="term" value="F:AP-1 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035651">
        <property type="term" value="F:AP-3 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036461">
        <property type="term" value="F:BLOC-2 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035646">
        <property type="term" value="P:endosome to melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903232">
        <property type="term" value="P:melanosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090383">
        <property type="term" value="P:phagosome acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF43">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGW06790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ERE78775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027263394.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23714" checksum="6FF6A98684BF9A9A" modified="2011-11-16" version="1">MQAPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFALKVLHWDPETVVRLQLWDIAGQERFGNMTRVYYREAMGAFIVFDVTRPATFEAVAKWKNDLDSKLTLPNGKPVSVVLLANKCDQGKDVLVNNGLKMDQFCKEHGFVGWFETSAKENINIDEASRCLVKHILANECDLIESIEPDIVKPHLTSPKVVSCSGCAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3I936</accession>
    <name>G3I936_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NPC intracellular cholesterol transporter 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Epididymal secretory protein E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Npc2</name>
        <name evidence="12" type="ORF">I79_020069</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner. Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS. Interacts with NEDD4L (via C2 domain). Interacts with NPC1L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH001565">
        <property type="protein sequence ID" value="EGW12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003511575.1">
        <property type="nucleotide sequence ID" value="XM_003511527.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027274322.1">
        <property type="nucleotide sequence ID" value="XM_027418521.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3I936"/>
    <dbReference type="SMR" id="G3I936"/>
    <dbReference type="STRING" id="10029.G3I936"/>
    <dbReference type="GlyGen" id="G3I936">
        <property type="glycosylation" value="1 site"/>
    </dbReference>
    <dbReference type="PaxDb" id="10029-XP_007626734.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015276.1">
        <property type="protein sequence ID" value="ENSCGRP00001011046.1"/>
        <property type="gene ID" value="ENSCGRG00001012790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770757"/>
    <dbReference type="KEGG" id="cge:100770757"/>
    <dbReference type="CTD" id="10577"/>
    <dbReference type="eggNOG" id="KOG4063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006223"/>
    <dbReference type="OMA" id="QNLFCWE"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010878">
        <property type="term" value="P:cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044732365" description="NPC intracellular cholesterol transporter 2" evidence="10">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="11">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGW12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001011046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027274322.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16471" checksum="2C99242B5825D6FA" modified="2011-11-16" version="1">MRFLAATVLLLALVAATQAEPLRYKDCGSKVGLIKEVNVSPCPTQPCELHKGQSYSVNVTFTSSTQSENSSATVYGILAGVPVFFPIPEPNGCKSGIKCPIQKDKTYSYLNKLPVKSEYPSLKLVVKWELQDDKEQNLFCWEIPVEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3IFR9</accession>
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            <fullName evidence="12">P2Y purinoceptor 6</fullName>
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        <name evidence="16 19" type="primary">P2ry6</name>
        <name evidence="15" type="ORF">I79_022592</name>
    </gene>
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        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for extracellular UTP &gt; ADP = 2-methylthio-ATP &gt; ADP-beta-S &gt; ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGV96978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035293292.1">
        <property type="nucleotide sequence ID" value="XM_035437401.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298239.1">
        <property type="nucleotide sequence ID" value="XM_035442348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IFR9"/>
    <dbReference type="STRING" id="10029.G3IFR9"/>
    <dbReference type="PaxDb" id="10029-XP_003513632.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001015218.1">
        <property type="protein sequence ID" value="ENSCGRP00001010989.1"/>
        <property type="gene ID" value="ENSCGRG00001012749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752781"/>
    <dbReference type="KEGG" id="cge:100752781"/>
    <dbReference type="CTD" id="5031"/>
    <dbReference type="eggNOG" id="ENOG502QRYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234621"/>
    <dbReference type="OMA" id="ICGGVWL"/>
    <dbReference type="OrthoDB" id="9881476at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled ADP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045029">
        <property type="term" value="F:G protein-coupled UDP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled UTP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071380">
        <property type="term" value="P:cellular response to prostaglandin E stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071415">
        <property type="term" value="P:cellular response to purine-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905835">
        <property type="term" value="P:cellular response to pyrimidine ribonucleotide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032962">
        <property type="term" value="P:positive regulation of inositol trisphosphate biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904707">
        <property type="term" value="P:positive regulation of vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030321">
        <property type="term" value="P:transepithelial chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000209">
        <property type="entry name" value="p2Y purinoceptor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001973">
        <property type="entry name" value="P2Y6_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF16">
        <property type="entry name" value="P2Y PURINOCEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01068">
        <property type="entry name" value="P2Y6PRNOCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="43"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV96978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001010989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_035298239.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36625" checksum="993C81BFA038BB14" modified="2011-11-16" version="1">MEQDNGTTQAPGLPPTTCVYREDFKRLLLTPVYSVVLVVGLPLNICVIAQICASRRTLTRSAVYTLNLALADLLYACSLPLLIYNYARGDHWPFGDIACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWVVCGVVWLVVTAQCLPTAIFAATGIQRNRTVCYDLSPPILSARYLPYGMALTVIGFLLPFTALLACYCRMARRLCRQDGPAGPVAQERRSKAARMAVVVAAVFAISFLPFHITKTAYLAVRSTPGVSCPVLETFAAAYKGTRPFASANSVLDPILFYFTQQKFRRQPHELLQKLTAKWQRQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3IGZ1</accession>
    <name>G3IGZ1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Dolk</name>
        <name evidence="11" type="ORF">I79_023068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JH002672">
        <property type="protein sequence ID" value="EGW14161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003514016.1">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027423178.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IGZ1"/>
    <dbReference type="STRING" id="10029.G3IGZ1"/>
    <dbReference type="PaxDb" id="10029-XP_007632622.1"/>
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    <dbReference type="KEGG" id="cge:100768385"/>
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    <dbReference type="eggNOG" id="KOG2468">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="G3IGZ1"/>
    <dbReference type="OMA" id="EIHWPGT"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR032974">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="130"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGW14161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027278979.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="14 16">
        <name type="scientific">Cricetulus griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Nat. Biotechnol." volume="29" first="735" last="741">
            <title>The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan H.C."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
            <dbReference type="PubMed" id="21804562"/>
            <dbReference type="DOI" id="10.1038/nbt.1932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CHO K1 cell line</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.</title>
            <authorList>
                <person name="Xu X."/>
                <person name="Nagarajan H."/>
                <person name="Lewis N.E."/>
                <person name="Pan S."/>
                <person name="Cai Z."/>
                <person name="Liu X."/>
                <person name="Chen W."/>
                <person name="Xie M."/>
                <person name="Wang W."/>
                <person name="Hammond S."/>
                <person name="Andersen M.R."/>
                <person name="Neff N."/>
                <person name="Passarelli B."/>
                <person name="Koh W."/>
                <person name="Fan C.H."/>
                <person name="Wang J."/>
                <person name="Gui Y."/>
                <person name="Lee K.H."/>
                <person name="Betenbaugh M.J."/>
                <person name="Quake S.R."/>
                <person name="Famili I."/>
                <person name="Palsson B.O."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="JH003121">
        <property type="protein sequence ID" value="EGW11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027241435.1">
        <property type="nucleotide sequence ID" value="XM_027385634.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027268094.1">
        <property type="nucleotide sequence ID" value="XM_027412293.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3IIW7"/>
    <dbReference type="STRING" id="10029.G3IIW7"/>
    <dbReference type="PaxDb" id="10029-XP_007610536.1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007903.1">
        <property type="protein sequence ID" value="ENSCGRP00001005172.1"/>
        <property type="gene ID" value="ENSCGRG00001006746.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cge:100771168"/>
    <dbReference type="eggNOG" id="ENOG502SJS1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="VYCMAFI"/>
    <dbReference type="OrthoDB" id="9445355at2759"/>
    <dbReference type="Proteomes" id="UP000001075">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tmA_OR8D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGW11512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001005172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027268094.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35201" checksum="43649AAFCEFD31C7" modified="2011-11-16" version="1">MLQGNISRVTEFILAGLTEKPEFQLPLFVLFLGIYVVTVVGNLGMITLIQFSSHLHTPMYVFLSSLSFIDFCHSTVITPKMLVNFVTQKNIISYPECMTQLYCFLVFGIAECHMLAAMAYDRYVAICNPLLYNAMMSYQVCFWMIFGVYCMAFIGATTHTVCMLRVHFCKLDVINHYFCDLFPLLELSCSDTFINEVVVLCFSVFNIFVPTLTILSSYIFIIASILQIKSTEGRSKAFGTCSSHISAVAIFFGSLAFMYLQPSSVNSMDQGKVSSVFYTIVVPMMNPLIYSVRNKDVKVALNKFLERKCFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-27" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q91Y26</accession>
    <name>NOC3L_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName>Nucleolar complex protein 3 homolog</fullName>
            <shortName>NOC3 protein homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>NOC3-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Nucleolar complex-associated protein 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NOC3L</name>
    </gene>
    <organism>
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2001-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bair C.-H."/>
                <person name="Chang W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <tissue>Ovary</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF371372">
        <property type="protein sequence ID" value="AAK53433.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001231221.1">
        <property type="nucleotide sequence ID" value="NM_001244292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q91Y26"/>
    <dbReference type="SMR" id="Q91Y26"/>
    <dbReference type="PaxDb" id="10029-NP_001231221.1"/>
    <dbReference type="GeneID" id="100689254"/>
    <dbReference type="KEGG" id="cge:100689254"/>
    <dbReference type="CTD" id="64318"/>
    <dbReference type="eggNOG" id="KOG2153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000173473" description="Nucleolar complex protein 3 homolog">
        <location>
            <begin position="1"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q8WTT2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="800" mass="92471" checksum="8148DD5F266F964B" modified="2001-12-01" version="1">MKARRNKKQVPSFRKLIKTSKVKLEYKLKNKQFKQQSTIKKYRKEQRKLRQAVKDAVSKKPFPLEDPKSKRPVKGMEREEEDEEDQALPLDMMDDDDLQLMKDLGQKASFLTRDLSSSEPVHIKKRKHESVIDKYEKMPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDIQQEEEDEEELEVEEEVVENPIQELTIEEHLIVRKKKLQEKKIQIATLASSILSDPESNIKKLKELRSMLMEQDPDVAVTVRKLVIISLMELFKDITPSYKIRPLTEAEKSTKIRKETQKLREFEEGLVSQYKFYLENLEQIVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDGSKLVSEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKTLSRMQRKWKKAEEKLERELREAEASESTERKLKLHTETLNIVFVTYFRILKKAQRSPLLPAVLEGLAKFAHLINVEFFDDLLVVLHTLIESGDLSYQESLHCVQTAFHILSGQGDVLNIDPMKFYTHLYKTLFKLHAGATNDGIEIVLHCLDVMLSKRRKQVSHQRALAFIKRLCTLALQVLPNSSIGLLATTRILMHTFPRTDLLLDNESQGSGVFLPELEEPEYCNAQNTALWELHALRRHYHPVVQRFAVHLLAGAPSEGSEALKPELSRRSAVELFEAYSMAAMTFNPPVEPSNSKKKDKLLQGDSFLNEDLNQLIKRYCNEVTTEIPLDFTKCLKTSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061IB50</accession>
    <name>A0A061IB50_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 7B, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIIb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">LOC113834565</name>
        <name evidence="13" type="ORF">H671_3g9031</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2013" name="Nat. Biotechnol." volume="31" first="694" last="695">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puhler A."/>
                <person name="Borth N."/>
            </authorList>
            <dbReference type="PubMed" id="23929341"/>
            <dbReference type="DOI" id="10.1038/nbt.2645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-03" db="EMBL/GenBank/DDBJ databases">
            <title>Chinese hamster genome sequenced from sorted chromosomes.</title>
            <authorList>
                <person name="Brinkrolf K."/>
                <person name="Rupp O."/>
                <person name="Laux H."/>
                <person name="Kollin F."/>
                <person name="Ernst W."/>
                <person name="Linke B."/>
                <person name="Kofler R."/>
                <person name="Romand S."/>
                <person name="Hesse F."/>
                <person name="Budach W.E."/>
                <person name="Galosy S."/>
                <person name="Muller D."/>
                <person name="Noll T."/>
                <person name="Wienberg J."/>
                <person name="Jostock T."/>
                <person name="Leonard M."/>
                <person name="Grillari J."/>
                <person name="Tauch A."/>
                <person name="Goesmann A."/>
                <person name="Helk B."/>
                <person name="Mott J.E."/>
                <person name="Puehler A."/>
                <person name="Borth N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIIb family.</text>
    </comment>
    <dbReference type="EMBL" id="KE671503">
        <property type="protein sequence ID" value="ERE80175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035297186.1">
        <property type="nucleotide sequence ID" value="XM_035441295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061IB50"/>
    <dbReference type="Ensembl" id="ENSCGRT00001009776.1">
        <property type="protein sequence ID" value="ENSCGRP00001006242.1"/>
        <property type="gene ID" value="ENSCGRG00001008405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113834565"/>
    <dbReference type="KEGG" id="cge:113834565"/>
    <dbReference type="GeneTree" id="ENSGT00390000012178"/>
    <dbReference type="OrthoDB" id="9937520at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000030759">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01403">
        <property type="entry name" value="Cyt_c_Oxidase_VIIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.51.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7B, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.51.10">
        <property type="entry name" value="Cytochrome C Oxidase, chain K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008433">
        <property type="entry name" value="Cyt_c_oxidase_suVIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023272">
        <property type="entry name" value="Cyt_c_oxidase_suVIIB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16716">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16716:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05392">
        <property type="entry name" value="COX7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81423">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ERE80175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001006242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035297186.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9185" checksum="58F09132934307F9" modified="2014-09-03" version="1">MLPFARNALSRLQVRSIQQVVARQSHQKRTPNFHDKYGNAILASGALFCISTWTYTVTQIGIEWNLSPVGRVTPKEWRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HDJ2</accession>
    <name>A0A3L7HDJ2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">LOC100770865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511775.1">
        <property type="nucleotide sequence ID" value="XM_003511727.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027278793.1">
        <property type="nucleotide sequence ID" value="XM_027422992.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HDJ2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001017660.1">
        <property type="protein sequence ID" value="ENSCGRP00001013423.1"/>
        <property type="gene ID" value="ENSCGRG00001014570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770865"/>
    <dbReference type="KEGG" id="cge:100770865"/>
    <dbReference type="OMA" id="WYSRDVA"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001013423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027278793.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34275" checksum="10E0778C5BCD8BFD" modified="2019-02-13" version="1">MAAVMAFAVLRQRMMRWPQSSYAGLAPLRVARGSVLGFSFRSGMVWRPSSSTAEAAATKAEDSSFLQWFLLLIPATAFGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPADLMELKSMEYRPVKVRGHFDHSKELYIMPRTMVDPAREAQDAGRISSSMESGAYVVTPFHCSDLGITILVNRGFVPKKKVNPETRQKGQVLGEVDLVGIVRLTETRKPFVPENSPQQNHWHYRDLEAMAKITGADPIFIDADFQSTIPGGPIGGQTRVTLRNEHMQYIITWYGLCAATSYLWFQKFVRRTPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HHL3</accession>
    <name>A0A3L7HHL3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ras-related protein R-Ras isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Related RAS viral (r-ras) oncogene</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">Rras</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276510.1">
        <property type="nucleotide sequence ID" value="XM_027420709.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HHL3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001025019.1">
        <property type="protein sequence ID" value="ENSCGRP00001020775.1"/>
        <property type="gene ID" value="ENSCGRG00001019817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766263"/>
    <dbReference type="KEGG" id="cge:100766263"/>
    <dbReference type="CTD" id="6237"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060325">
        <property type="term" value="P:face morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002521">
        <property type="term" value="P:leukocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900148">
        <property type="term" value="P:negative regulation of Schwann cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904906">
        <property type="term" value="P:positive regulation of endothelial cell-matrix adhesion via fibronectin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001214">
        <property type="term" value="P:positive regulation of vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036135">
        <property type="term" value="P:Schwann cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001020775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027276510.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23721" checksum="4016AA23F8CD2E25" modified="2019-02-13" version="1">MSSGAASGTGRGRPRGGGPGPRDPPPGETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICTVDGIPARLDILDTAGQEEFGAMREQYMRAGNGFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPVVLVGNKADLETQRQVLRSEASSFSASHHMAYFEASAKLRLNVDEVFEQLVRTVRKYQEQELPPSPPSAPRKKGGGCPCILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7HNY0</accession>
    <name>A0A3L7HNY0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 300</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">Cfap300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFAP300 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027270963.1">
        <property type="nucleotide sequence ID" value="XM_027415162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7HNY0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027289.1">
        <property type="protein sequence ID" value="ENSCGRP00001023044.1"/>
        <property type="gene ID" value="ENSCGRG00001021391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756887"/>
    <dbReference type="KEGG" id="cge:100756887"/>
    <dbReference type="CTD" id="85016"/>
    <dbReference type="GeneTree" id="ENSGT00510000047559"/>
    <dbReference type="OrthoDB" id="10259249at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029416">
        <property type="entry name" value="CFAP300"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14926">
        <property type="entry name" value="CFAP300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027270963.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30866" checksum="E3405DB6AF2A967D" modified="2019-02-13" version="1">MAAGEPGSLGGFYFRFLPQRTFSSLNTREVTSRLRQWSMLGRIQAQAFSFDQTFQPYQKDDFVMAFFTDPNVIPNLQLLSDSSGQWITLGTEVKKIEAVNVPCTQLSMSFFQRLYDENIVRESGHIVKCFDSFCDPFLISDELRKVLLMEDSEKYEVFSPQEREEFLFCLFKHLCLGGSLCQYEDMLKPYLETAKLIYKDLVSVRKHPRTKEIQITSSVFKVKAYDSAGVCYPSAKEHEQTFSYFVVDPIKRHVNVLYHCYGVGEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I0Z2</accession>
    <name>A0A3L7I0Z2_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox protein Nkx-2.3 isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">NK2 homeobox 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">Nkx2-3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027263070.1">
        <property type="nucleotide sequence ID" value="XM_027407269.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I0Z2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013988.1">
        <property type="protein sequence ID" value="ENSCGRP00001009769.1"/>
        <property type="gene ID" value="ENSCGRG00001011819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768689"/>
    <dbReference type="KEGG" id="cge:100768689"/>
    <dbReference type="CTD" id="159296"/>
    <dbReference type="GeneTree" id="ENSGT00940000157556"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043367">
        <property type="term" value="P:CD4-positive, alpha-beta T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022612">
        <property type="term" value="P:gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001776">
        <property type="term" value="P:leukocyte homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048535">
        <property type="term" value="P:lymph node development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030225">
        <property type="term" value="P:macrophage differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042475">
        <property type="term" value="P:odontogenesis of dentin-containing tooth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048541">
        <property type="term" value="P:Peyer's patch development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002317">
        <property type="term" value="P:plasma cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048621">
        <property type="term" value="P:post-embryonic digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050678">
        <property type="term" value="P:regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046541">
        <property type="term" value="P:saliva secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000078">
        <property type="entry name" value="NK2 homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF32">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027263070.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="37965" checksum="44079F8D464655C6" modified="2019-02-13" version="1">MMLPSPVTSTPFSVKDILNLEHQQHFHGAHLQAELEQHFQSAPCMLAAADGTQFSDAGEEEEEEEGEKLSYLNSLAAAEGHGDSGLCPQSYVHTVLRDSCSRPKEQEEEVVRERSQKSCQLKKSLEATADCKASEDGERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPPPPRRVAVPVLVRDGKPCVTPSAQAYGSPYSVGAGAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTGGGGGGASPATTAMQPACSATGGGSFVNVGNLGGFGSGGGAQPLHQGAAAGAACAQGTLQGIRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7I7X9</accession>
    <name>A0A3L7I7X9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 20 21 22" type="primary">Ndufs5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20 21 22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20 21 22">17A/GY</strain>
            <tissue evidence="20 21 22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003505092.1">
        <property type="nucleotide sequence ID" value="XM_003505044.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643743.1">
        <property type="nucleotide sequence ID" value="XM_007645553.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007643744.1">
        <property type="nucleotide sequence ID" value="XM_007645554.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255008.1">
        <property type="nucleotide sequence ID" value="XM_027399207.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255009.1">
        <property type="nucleotide sequence ID" value="XM_027399208.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027255010.1">
        <property type="nucleotide sequence ID" value="XM_027399209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7I7X9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012797.1">
        <property type="protein sequence ID" value="ENSCGRP00001008664.1"/>
        <property type="gene ID" value="ENSCGRG00001010913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770445"/>
    <dbReference type="KEGG" id="cge:100770445"/>
    <dbReference type="CTD" id="4725"/>
    <dbReference type="OMA" id="RQQRDKM"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027255008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027255009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027255010.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12542" checksum="60EC32ED52B1B4C6" modified="2019-02-13" version="1">MPFLDVQKRLGISLDRHLVFQSVEQPYKIPSRCHAFEKEWIECSHGIGATRAKKECNIEYEDYKECLLRFKTIMRLNEIKLHRNKLMKEGKYTPPPHFVGKGDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IAE6</accession>
    <name>A0A3L7IAE6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial ubiquitin ligase activator of NFKB 1</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E3 ubiquitin-protein ligase MUL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Protein Hades</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase NFKB 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 26 27 28" type="primary">Mul1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="26 27 28" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="26 27 28">17A/GY</strain>
            <tissue evidence="26 27 28">Liver</tissue>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="1 29">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homooligomer. Interacts with MAP3K7/TAK1. Interacts with UBC9. Interacts with and sumoylates DNM1L. Interacts with MAVS. Interacts with TP53 (via N-terminus); the interaction leads to ubiquitination and proteasomal degradation of TP53.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_016974854.3"/>
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    <dbReference type="RefSeq" id="XP_016830344.2">
        <property type="nucleotide sequence ID" value="XM_016974855.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027399802.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027399803.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035439482.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_035454849.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A3L7IAE6"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031765.1">
        <property type="protein sequence ID" value="ENSCGRP00001027518.1"/>
        <property type="gene ID" value="ENSCGRG00001024511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100757014"/>
    <dbReference type="KEGG" id="cge:100757014"/>
    <dbReference type="CTD" id="79594"/>
    <dbReference type="GeneTree" id="ENSGT00390000012141"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:neuronal cell body"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cellular response to exogenous dsRNA"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial fission"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:mitochondrion localization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of chemokine (C-C motif) ligand 5 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050689">
        <property type="term" value="P:negative regulation of defense response to virus by host"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060339">
        <property type="term" value="P:negative regulation of type I interferon-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1903861">
        <property type="term" value="P:positive regulation of dendrite extension"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of mitochondrial fission"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033235">
        <property type="term" value="P:positive regulation of protein sumoylation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905091">
        <property type="term" value="P:positive regulation of type 2 mitophagy"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein destabilization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Mitochondrial ubiquitin ligase activator of NFKB 1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    <dbReference type="InterPro" id="IPR051652">
        <property type="entry name" value="MDM2_MDM4_MUL1"/>
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        <property type="entry name" value="MUL1-like"/>
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        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183">
        <property type="entry name" value="MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183:SF4">
        <property type="entry name" value="MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="26 27 28" id="KW-0436">Ligase</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00012483"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="352" mass="39930" checksum="D3293778326D3B0E" modified="2019-02-13" version="1">MEGGSLPSLGQFILLGTSSMITAVLYSIYRQKAQVAQELKGAKKIHLGEDLKGILLEATGKCVPYAVIEGAVQSVKETLNSQFVENCKGVIQRSTLQEHKMVWNRTTHLWNDYSKIIHQRTNTVPFDLVPHEDGVAVAVRVLKPLDSVDLGLETVYEKFHPSVQSFADVIGHYISGERPRGILETEEMLKVGATITGVGELVLDNNSVRLQPPKQGLQYYLSSQDFDSLLHRQESSVRLWKILVLVFGFATCTTLFFILRRQYLQWQERLRQQQLQEEFREHEAHLLSQALPEDRESLKSSCVVCLSSFKSCVFLECGHVCSCRQCYLALPEPKRCPVCRREITRMIPLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IBY9</accession>
    <name>A0A3L7IBY9_CRIGR</name>
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        <recommendedName>
            <fullName evidence="5 18">Alkaline phosphatase</fullName>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="5 18"/>
    <dbReference type="RefSeq" id="XP_027253261.1">
        <property type="nucleotide sequence ID" value="XM_027397460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IBY9"/>
    <dbReference type="Ensembl" id="ENSCGRT00001031262.1">
        <property type="protein sequence ID" value="ENSCGRP00001027015.1"/>
        <property type="gene ID" value="ENSCGRG00001024150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751196"/>
    <dbReference type="KEGG" id="cge:100751196"/>
    <dbReference type="GeneTree" id="ENSGT00950000183063"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF43">
        <property type="entry name" value="INTESTINAL-TYPE ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 16 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16 18" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044594467" description="Alkaline phosphatase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="497"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001027015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027253261.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="59903" checksum="DAAB529E644FB2BE" modified="2019-02-13" version="1">MQGACLLLLLGLQLQLSLSVIPVEEENPAFWNQKAAEALNVAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETPLAMDSFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTFGNEVISVMYRAKQAGKSVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPASALQEGCKDIATQLISNMDINVILGGGRKYMFPAGTPDPEYPNDVNQTGTRLDGRDLVQEWLSKHQGSQYVWNREELIQKSLDPSVTYLMGLFEPVDTKFEIQRDPLMDPSLKDMTEAALRVLSRNPKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDTAIEKASQLTSEKDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLKALDGKSYTSILYGNGPGYVGTGERPNVTAAESRDPSYQQQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEENYIAHVMAFAGCLEPYTNCGLAPPADDSSATAPGQTSTTTRQTTTTSQTTTPVQSSAGSLGPATTPLPLTLLAGTLLLLLGAAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7IJN1</accession>
    <name>A0A3L7IJN1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7 10">Arylacetamide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">Aadac</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003511717.1">
        <property type="nucleotide sequence ID" value="XM_003511669.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247478.1">
        <property type="nucleotide sequence ID" value="XM_027391677.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7IJN1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001023244.1">
        <property type="protein sequence ID" value="ENSCGRP00001019000.1"/>
        <property type="gene ID" value="ENSCGRG00001018575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100771815"/>
    <dbReference type="KEGG" id="cge:100771815"/>
    <dbReference type="CTD" id="13"/>
    <dbReference type="GeneTree" id="ENSGT00940000155975"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010898">
        <property type="term" value="P:positive regulation of triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF28">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="6">
        <location>
            <begin position="106"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="6">
        <location>
            <begin position="315"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027247478.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45518" checksum="EF8673E2B906677D" modified="2019-02-13" version="1">MGKTILLLVAVVLVAYYVYVPLPGDIEEPWKLMLQTTRLKVMMDLVSFAELLGINHYMDTIQILMKFQELPATSDENVTVTDTAFNSVPVRIYVPKRKSESLRRGLFFIHGGGWCLGSNALLEYDLLARQIAERLDAVVLSTNYGLAPKYHFPRQFEDVYDALRWFLQEDILERYGVDPQRVGVSGDSAGGNLAAAVAQQIVQDPDVKTKLKVQALVYPALQALDMNLPSYQEGLYFPILSPLLMTRFWSEYFTTDRTLEKAMLLNQHVPMESSHLFQFVNWSSLLPERYKKGYFYKSPTPGSSELSKKYPGFLDVKACPLLANDNILSQLPRTYIITCQYDVLRDDGLMYAMRLQNAGVHVTHHHVENGFHGAFTLHGFKISYRLQNQYFSWLMENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3L7INC4</accession>
    <name>A0A3L7INC4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHX15</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAH box protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Dhx15</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Identified in the Intron Large spliceosome complex (IL, also named intron lariat spliceosome), a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. The IL complex exists in two distinct conformations, one with the DHX15 (ILS2) and one without (ILS1). Interacts with TFIP11 (via G-patch domain); indicative for a recruitment to the IL complex. Interacts with SSB/La. Interacts with GPATCH2 (via G-patch domain); promoting the RNA helicase activity. Interacts with NKRF (via G-patch domain); promoting the RNA helicase activity. Interacts with NLRP6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_007651353.1">
        <property type="nucleotide sequence ID" value="XM_007653163.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027242767.1">
        <property type="nucleotide sequence ID" value="XM_027386966.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3L7INC4"/>
    <dbReference type="SMR" id="A0A3L7INC4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030352.1">
        <property type="protein sequence ID" value="ENSCGRP00001026106.1"/>
        <property type="gene ID" value="ENSCGRG00001023527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100764898"/>
    <dbReference type="KEGG" id="cge:100764898"/>
    <dbReference type="CTD" id="1665"/>
    <dbReference type="GeneTree" id="ENSGT00940000155800"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF95">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="147"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="338"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027242767.1"/>
        </source>
    </evidence>
    <sequence length="795" mass="90963" checksum="247FC06327678D95" modified="2019-02-13" version="1">MSKRHRLDLGEDYPSGKKRAGTDGKDRDRDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHTGHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDRIIAKLQSKEYSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LEM4</accession>
    <name>A0A8C2LEM4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">WW domain-binding protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Formin-binding protein 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">WW domain-containing-binding protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">Wbp4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the spliceosome B complex. Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1. Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68. Interacts via the WW domains with the Pro-rich domains of WBP11. Interacts with SNRNP200.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_007652199.1">
        <property type="nucleotide sequence ID" value="XM_007654009.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027249846.1">
        <property type="nucleotide sequence ID" value="XM_027394045.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LEM4"/>
    <dbReference type="Ensembl" id="ENSCGRT00001002506.1">
        <property type="protein sequence ID" value="ENSCGRP00001002017.1"/>
        <property type="gene ID" value="ENSCGRG00001002031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752786"/>
    <dbReference type="KEGG" id="cge:100752786"/>
    <dbReference type="CTD" id="11193"/>
    <dbReference type="GeneTree" id="ENSGT00390000013956"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070064">
        <property type="term" value="F:proline-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000767">
        <property type="entry name" value="WW domain-binding protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="17">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="190"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_027249846.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42485" checksum="0A45B2C9539691BB" modified="2022-01-19" version="1">MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVARRISEIKQKSLDKAKEEEKASKEFAAMEAAALKAYQEDLKRLGLESDIPEPSISPVTSTVQPTSTSDQPKEKKKKKEKKKKDPSKGRWVEGVTADGHCYYYDLITGASQWEKPEGFQGNLKKTAAKAVWVEGLSEDGYTYYYNTETGESKWEKPDDFIPHTGDVPSSKDKEKSPESLEESKSSDSHSDSDGEQKKPGEASAETKKLVIKFKEKNKSTEKRTDPEIQKEKSTPKQNPSTTNEEKSKPLKKLTNPYGEWQEIKQEAESQEEVDLELPSTESEYLSAPEAAAGEIKVVFKEKTVSSLGVAADGVAPVFKKRKIENGRSRNLRQRGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LF31</accession>
    <name>A0A8C2LF31_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10 13">Interferon alpha-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">LOC100751221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha/beta interferon family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027256317.1">
        <property type="nucleotide sequence ID" value="XM_027400516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LF31"/>
    <dbReference type="Ensembl" id="ENSCGRT00001003750.1">
        <property type="protein sequence ID" value="ENSCGRP00001002739.1"/>
        <property type="gene ID" value="ENSCGRG00001003121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100751221"/>
    <dbReference type="KEGG" id="cge:100751221"/>
    <dbReference type="GeneTree" id="ENSGT01000000214430"/>
    <dbReference type="OrthoDB" id="9833506at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="IFab"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.1250.10:FF:000001">
        <property type="entry name" value="Interferon alpha"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
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    <dbReference type="InterPro" id="IPR000471">
        <property type="entry name" value="Interferon_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691:SF60">
        <property type="entry name" value="INTERFERON ALPHA-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691">
        <property type="entry name" value="TYPE I INTERFERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00143">
        <property type="entry name" value="Interferon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00266">
        <property type="entry name" value="INTERFERONAB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00076">
        <property type="entry name" value="IFabd"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="INTERFERON_A_B_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3 8" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044678529" evidence="9">
        <location>
            <begin position="24"/>
            <end position="186"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001002739.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027256317.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21256" checksum="BB3241A254542B60" modified="2022-01-19" version="1">MTRSCAFLMSLVVMSYWSACCLGCHLPQTHNLRNKRALTLLAQMRRLSPLSCLKDRKDFAFPLEKVDVQHIQKTQAIPVLQQLTQQVLILFSSKDSSAAWETTLLDTFCTGLHQQLSDLRACLMQQEGVQKTSLSQEDSLVAVRKYFHRITAYLREKNHSPCAWEVVRAEVWRALSASANLLARFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LK72</accession>
    <name>A0A8C2LK72_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="14">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Rps6ka4</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="14"/>
    <dbReference type="RefSeq" id="XP_027264263.1">
        <property type="nucleotide sequence ID" value="XM_027408462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LK72"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007261.1">
        <property type="protein sequence ID" value="ENSCGRP00001004798.1"/>
        <property type="gene ID" value="ENSCGRG00001006171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750354"/>
    <dbReference type="KEGG" id="cge:100750354"/>
    <dbReference type="CTD" id="8986"/>
    <dbReference type="GeneTree" id="ENSGT00940000161083"/>
    <dbReference type="OrthoDB" id="6764942at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035175">
        <property type="term" value="F:histone H3S10 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044022">
        <property type="term" value="F:histone H3S28 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070498">
        <property type="term" value="P:interleukin-1-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05614">
        <property type="entry name" value="STKc_MSK2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000208">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037714">
        <property type="entry name" value="MSK2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="33"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="411"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="728"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="39"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="417"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027264263.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="85613" checksum="29D4FBF2005F6B5C" modified="2022-01-19" version="1">MGDEDEEEGCAVELQITEANLTGHEEKVSVENFALLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPLRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKNHPFFQGLDWAALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPAGSPPPGDSRIFQGYSFVAPSILFDHNNAVMTDVLEAPGAGHRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEENTQREVAALRLCQSHPNVVNLHEVFHDQLHTYLVLELLRGGELLERIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPAGPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGSSGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRSSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSAAASRRGSPVPASSGRLSASATKGAPRRANGPLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LKN1</accession>
    <name>A0A8C2LKN1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Wee1-like protein kinase</fullName>
            <ecNumber evidence="14">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 24" type="primary">Wee2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="24">17A/GY</strain>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10597"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="14"/>
    <dbReference type="RefSeq" id="XP_003503082.1">
        <property type="nucleotide sequence ID" value="XM_003503034.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027247337.1">
        <property type="nucleotide sequence ID" value="XM_027391536.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LKN1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001007361.1">
        <property type="protein sequence ID" value="ENSCGRP00001004854.1"/>
        <property type="gene ID" value="ENSCGRG00001006258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100750772"/>
    <dbReference type="KEGG" id="cge:100750772"/>
    <dbReference type="CTD" id="494551"/>
    <dbReference type="GeneTree" id="ENSGT00940000158803"/>
    <dbReference type="OMA" id="PLKDEMT"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007143">
        <property type="term" value="P:female meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035038">
        <property type="term" value="P:female pronucleus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900194">
        <property type="term" value="P:negative regulation of oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080154">
        <property type="term" value="P:regulation of fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060631">
        <property type="term" value="P:regulation of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000115">
        <property type="entry name" value="Wee1-like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000217">
        <property type="entry name" value="Wee1-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017164">
        <property type="entry name" value="Wee1-like_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF75">
        <property type="entry name" value="WEE1-LIKE PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037281">
        <property type="entry name" value="Wee1-like_protein_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="209"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="215"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001004854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_027247337.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60369" checksum="2107E78FCA1B5BB7" modified="2022-01-19" version="1">MADGRADQRLNKELNFSFCEEDTEKGAQKTAGGGAAEAQSQKSERDRDEEPEGPKSPPRDELYPSQNREKESPGPSLWIPVSSLPKCPETPKPHSKDRMPVNDNLSTPKNSMKQPEVSSVGKLSSRSSKHLGLTPTPFMDEKTSLSLVNINPFTPESYRKLFLQSSGKRKTRGSTEETGEGESTSEQWLPVKRSVLRETNMASRYEKEFLEVEKIGVGEFGVVYKCIKRLDGCIYAVKHSTKPFSGLSNDVDLHEVFAHAVLGHHPHVVRYYSSWAEDDHVVIQNEYCNGGSLQAAISENSVSGNHFPEPTLKDILLQISLGLKYIHNFGMVHMDIKPSNIFICRKMQSDSAVCSEEAESEDDWFLSASVTYKIGDLGHVTSINNPKVEEGDIRFLAKEILQENYQHLPKADIFALGLTMAMAAGAESLPINGDRWHHIREGNFPDILQELSDDFYGLLKSMIHPDPQKRPSAAALARSRIIRPFLEKTDELQEQLNLEKSKTATLERDLMKAKQIQIPQRDTYHSDPGTPEAFEDSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LT73</accession>
    <name>A0A8C2LT73_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">LOC100753634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator. TFIIA forms a complex with TBP. Interacts with HSF1 (via transactivation domain). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035308586.1">
        <property type="nucleotide sequence ID" value="XM_035452695.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312574.1">
        <property type="nucleotide sequence ID" value="XM_035456683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LT73"/>
    <dbReference type="Ensembl" id="ENSCGRT00001012636.1">
        <property type="protein sequence ID" value="ENSCGRP00001008507.1"/>
        <property type="gene ID" value="ENSCGRG00001010774.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753634"/>
    <dbReference type="KEGG" id="cge:100753634"/>
    <dbReference type="OMA" id="MTTFDKC"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001008507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035308586.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12376" checksum="2EC9506370A909DF" modified="2022-01-19" version="1">MAYQLYGNTTLGNSLQEGLDELIQSQQITPQLAFQVLLQCDKAINSALAQRVRNRVNFRDSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVAYGGKNTGSNAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2LZ72</accession>
    <name>A0A8C2LZ72_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Hematopoietic prostaglandin D synthase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
            <ecNumber evidence="13">5.3.99.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">GST class-sigma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Glutathione S-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glutathione-dependent PGD synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Glutathione-requiring prostaglandin D synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Prostaglandin-H2 D-isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 29" type="primary">Hpgds</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="29">17A/GY</strain>
            <tissue evidence="29">Liver</tissue>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2</text>
            <dbReference type="Rhea" id="RHEA:51232"/>
            <dbReference type="ChEBI" id="CHEBI:85166"/>
            <dbReference type="ChEBI" id="CHEBI:133979"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:51233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin H2 = prostaglandin D2</text>
            <dbReference type="Rhea" id="RHEA:10600"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57406"/>
            <dbReference type="EC" id="5.3.99.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:10601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EC" id="5.3.99.2" evidence="13"/>
    <dbReference type="RefSeq" id="XP_035304958.1">
        <property type="nucleotide sequence ID" value="XM_035449067.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035305750.1">
        <property type="nucleotide sequence ID" value="XM_035449859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2LZ72"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013925.1">
        <property type="protein sequence ID" value="ENSCGRP00001009706.1"/>
        <property type="gene ID" value="ENSCGRG00001011770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100768035"/>
    <dbReference type="KEGG" id="cge:100768035"/>
    <dbReference type="CTD" id="27306"/>
    <dbReference type="GeneTree" id="ENSGT00940000160278"/>
    <dbReference type="OMA" id="CEMIDET"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004667">
        <property type="term" value="F:prostaglandin-D synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019371">
        <property type="term" value="P:cyclooxygenase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000255">
        <property type="term" value="P:negative regulation of male germ cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009624">
        <property type="term" value="P:response to nematode"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010269">
        <property type="term" value="P:response to selenium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10295">
        <property type="entry name" value="GST_C_Sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000035">
        <property type="entry name" value="Hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="24">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="25">
        <location>
            <begin position="81"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00080594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001009706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_035304958.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23128" checksum="9AAE4A841684A664" modified="2022-01-19" version="1">MPNYKLIYFNMRGRAEIIRYIFAYLDIKYEDHRIELADWPQIKPTLPFGKIPVLEVGGLTLHQSLAIARYLTKNTDLAGKTELEQCQADAIVDTLDDFMSLFPWAEKNQDVKERTFKELLTCHAPLLLKDLDTYLGDKEWFIGNSVTWADFYWDICSTTLLVLKPDLLDTHPRLVSLRKKVQTIPAIAAWIQKRPQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2M3H3</accession>
    <name>A0A8C2M3H3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phospholipase A2</fullName>
            <ecNumber evidence="13">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">Pla2g2c</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="13"/>
    <dbReference type="RefSeq" id="XP_035294780.1">
        <property type="nucleotide sequence ID" value="XM_035438889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035314621.1">
        <property type="nucleotide sequence ID" value="XM_035458730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2M3H3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016644.1">
        <property type="protein sequence ID" value="ENSCGRP00001012410.1"/>
        <property type="gene ID" value="ENSCGRG00001013829.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100756754"/>
    <dbReference type="KEGG" id="cge:100756754"/>
    <dbReference type="CTD" id="391013"/>
    <dbReference type="GeneTree" id="ENSGT00910000144349"/>
    <dbReference type="OMA" id="CDRQSAY"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000008">
        <property type="entry name" value="Phospholipase A(2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF5">
        <property type="entry name" value="INACTIVE GROUP IIC SECRETORY PHOSPHOLIPASE A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044520769" description="Phospholipase A2" evidence="13">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="14">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_035294780.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17075" checksum="4174F7FD56274868" modified="2022-01-19" version="1">MKVTAVFIVFIFCWTTSTLSSFWQFQRMVKHVTGRSAFFSYYGYGCYCGLGGRGIPVDATDRCCWAHDCCYHKLKEHGCQPILNGYQFNIVNGSVACGCALSGSCLCGQKACECDKQSVYCFRKNLHSYEKTFKQVFLNRPQCGRRKLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MJZ1</accession>
    <name>A0A8C2MJZ1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Muscle and microspikes RAS</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14 15 16">Ras-related protein M-Ras isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 14 15 16" type="primary">Mras</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14 15 16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14 15 16">17A/GY</strain>
            <tissue evidence="14 15 16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003502552.1">
        <property type="nucleotide sequence ID" value="XM_003502504.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270067.1">
        <property type="nucleotide sequence ID" value="XM_027414266.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027270069.1">
        <property type="nucleotide sequence ID" value="XM_027414268.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027292440.1">
        <property type="nucleotide sequence ID" value="XM_027436639.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035299782.1">
        <property type="nucleotide sequence ID" value="XM_035443891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035311821.1">
        <property type="nucleotide sequence ID" value="XM_035455930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MJZ1"/>
    <dbReference type="Ensembl" id="ENSCGRT00001024108.1">
        <property type="protein sequence ID" value="ENSCGRP00001019864.1"/>
        <property type="gene ID" value="ENSCGRG00001019182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767950"/>
    <dbReference type="KEGG" id="cge:100767950"/>
    <dbReference type="CTD" id="22808"/>
    <dbReference type="GeneTree" id="ENSGT00940000156353"/>
    <dbReference type="OMA" id="DRDVYPM"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04145">
        <property type="entry name" value="M_R_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001019864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027270067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_027270069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035299782.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23876" checksum="0B3A11AFA96B3EC4" modified="2022-01-19" version="1">MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATSTHKLQCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MP98</accession>
    <name>A0A8C2MP98_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 20" type="primary">Heatr1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Ribosome biogenesis factor; required for recruitment of Myc to nucleoli. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in neuronal-lineage cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with MYC; the interaction is required for localization of MYC to the nucleolus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
            <location evidence="1 14">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007646367.1">
        <property type="nucleotide sequence ID" value="XM_007648177.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027265250.1">
        <property type="nucleotide sequence ID" value="XM_027409449.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001026049.1">
        <property type="protein sequence ID" value="ENSCGRP00001021805.1"/>
        <property type="gene ID" value="ENSCGRG00001020538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100763985"/>
    <dbReference type="KEGG" id="cge:100763985"/>
    <dbReference type="CTD" id="55127"/>
    <dbReference type="GeneTree" id="ENSGT00390000015845"/>
    <dbReference type="OMA" id="NDVMWKQ"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061351">
        <property type="term" value="P:neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000534">
        <property type="entry name" value="HEAT repeat containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 14" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 14" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="16">
        <location>
            <begin position="1856"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2110"/>
            <end position="2137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001021805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027265250.1"/>
        </source>
    </evidence>
    <sequence length="2143" mass="242139" checksum="775488E12062974C" modified="2022-01-19" version="1">MTSLAQQLQRLALPQTDPSLLTRHEVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPAFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNPDSLIACVLPYHETRVFVRVIQLLKISNPKHKWFWLSPVKQSGVPLARGTLVTHCYKDLGFMDFICSLVTKSVKAFAEYPGSSAQLRVLLAFYASTIVSALVAAENLSDNVVAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEDTFVNSLASQLIRTLTKVPSQVKDGLGCLIILLQRQKPEALGKKPFPHLCSVPDLIELLHGISESYDVSPLLRYMLPHLVASIVQHIAGEETEGTDGQIYKRHLEAILRKIPLTNNLDHLLASLLFEEYISYSSQEETHASEVALLNEQFLPLIRLLESKYPRTLDVVLEEHLKEITGLKKQELFHQFISLSTSGGKYQFLEDSDTSLMLSLNHPLAPVRLLAINHLKTVMKTAKEGIDETFIKEAILTRLGDDNVDVILSALSAFEIFQQHFNVEETISHLLNLFQRAELSKNKGWYRVLELAANILSKEEVLRKNDQLSNQVAVQLLPFMVITNDDIESPDMKIAVHLSKSGICSLHPLLRGWKEALGNIIKSRKSREIIGVGNQKMVQLLAFNLSSGDRSSMLKLVEELINAGEKESYNLKQKVTFHVIVSALISCCSSFRETCFPFAVRVFSLLQKKIEKLKSIITAVEIPAEWHLELMLNRGLPEELWVHYVQQLRIAQRVAVEDAVLLVFSLKCFIFALKAPKSFPTGATWWNPEQLDDDSRHYLHLLIGVFEMLLKVSDAMHFRVLMKLIMKVHLQDVLQLFKFLSVLWTYGSSLSNPLNCTVKSELQTQALYIGSLMLSSQNTQCKQKLASATSPVVPSLLLSLGSPVKEVRRAAVQCLQALSGVASKFQLVIEHLVPKAEEITSDATYVVQDLATLFDELQKEEKQKSHQRLSETLRSLLHCIYGCPSYVAKDLMKVFQDVNSEMVLAQLLPMVEQLLKKVEKEPTAVLKDEAIVLHLTLGKYNEYSASLLHKDSKSLDLFIKAVHTTKDLHPGMPTIQITALEKITKPFFAAVSDGKVQQKLLCVLFDLLVNCKNSHCVQTVGSVFKGISVDAEQIRIELEPRDKAKSLGTIQQTRRQKMQQKKSQDVESVQEVEGPYWQRVTLILELLQHKKKLKGPQILIPTLFNLLSRCLEPLSSEQGNMEYTKQLILSCLLNICQKLSPDGGRIPKDVLDEEKFNVELIVQCIRLSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDAYSFQVISKTVKMVIPALIQSDTGDSLEVTRNVEEIVVKIIGVFVDALPHVPEHRRLPILVQLVDTLGAEKFLWILLVLLFEQYVTKTVLVAAYGEKDAILEADTEFWISVCCEFSVQHQVQSLMHILQYLEKLPEEKEEATPKTVSSKSEVQEEMLPVFKVDTHTSKQLRHFKYLSVSFMAQLLASNLFLKKVVESGGPNILHGFEQRLLETVLGYINVVAQTMEKNADKLTVKFWRALLSKAYDMLDKVNALLPTETFVSVVRGLVGNPLPSVRRKALDLLNNKLQQNTFWKKKTVHRFLKLVPVLLAIVQHKKKEEEDEQAINRQTALYTLKLLCKNFGAGNREPFIPVLSAAVQLIAPEKKEEKNVLGSALLCIAEVTSTLEALAIPQLPSLMPSLLTAMKNTSELVHSEVCLLSALAALHKVVETLPHFISPYLEGLLTQVIHLEKITSEMGPASQANIRLTSLKKTLATTLSPRVLLPSISKTFKQIQKNWKNHMGPFMSILQEHIGVMKKEELLSHQSELTTFFLGALDFRAQHSEDDLEEVGKTESWIIGCLVAMVVKLSEVTFRPLFFKLYDWAKTEDAPKDRLLTFYNLTNCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSEQDPEKCCLLLQFILNCLYKIFLFDTQNFMSKERAEALMMPLVDQLENRLGGEERFQERVTKHLVPCIAQFSVAVADDSMWKPLNYQILLKTRDSSPKVRFAALITVLAVAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETLLGEPLQSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MRZ0</accession>
    <name>A0A8C2MRZ0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphodiesterase</fullName>
            <ecNumber evidence="10">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Pde7b</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_027257720.1">
        <property type="nucleotide sequence ID" value="XM_027401919.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027298483.1">
        <property type="nucleotide sequence ID" value="XM_027442682.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MRZ0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027162.1">
        <property type="protein sequence ID" value="ENSCGRP00001022917.1"/>
        <property type="gene ID" value="ENSCGRG00001021298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100753277"/>
    <dbReference type="KEGG" id="cge:100753277"/>
    <dbReference type="CTD" id="27115"/>
    <dbReference type="GeneTree" id="ENSGT00940000159413"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000004">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="149"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="225"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027257720.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57320" checksum="69511BC4A5D880A4" modified="2022-01-19" version="1">MPVLERYFHSAELGRRWTAPEGVLPSALGSRPGCQQGPLPWDLPEMIRMVKLVWKSKSELQATKPRGILENEDALHSFPGDVRLRGQTGVPAERRGSYPFIDFRLLNNTTHSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLENVQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSENMLSHLAHNKAQWKSLLSKQHRRRGSGQDSATPTSETLEQTEGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MT53</accession>
    <name>A0A8C2MT53_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hyaluronidase</fullName>
            <ecNumber evidence="10">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Hyal4</name>
        <name evidence="14" type="synonym">LOC100758272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 10">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="10"/>
    <dbReference type="RefSeq" id="XP_035306777.1">
        <property type="nucleotide sequence ID" value="XM_035450886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MT53"/>
    <dbReference type="GlyCosmos" id="A0A8C2MT53">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSCGRT00001027715.1">
        <property type="protein sequence ID" value="ENSCGRP00001023469.1"/>
        <property type="gene ID" value="ENSCGRG00001021691.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cge:100758272"/>
    <dbReference type="GeneTree" id="ENSGT01020000230364"/>
    <dbReference type="OMA" id="CAKAFMK"/>
    <dbReference type="OrthoDB" id="5796153at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030207">
        <property type="term" value="P:chondroitin sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000065">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF7">
        <property type="entry name" value="HYALURONIDASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00848">
        <property type="entry name" value="SPERMPH20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="8">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="59"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="381"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001023469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035306777.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54731" checksum="34DCBDFA77D8D661" modified="2022-01-19" version="1">MKLLSEGQLRLCVVQPVRLTSGLLIFFILKSISSLKPARLPVYQRKPFIAAWNAPTDLCLIKYNLTMNLKIFQMIGSPRLKDGEQNVTIFYANKLGYYPLYTSEGVPINGGLPQNTSLQVHLEKAAQDISYYIPSKNFSGLAVIDWEYWRPQWARNWDTKDIYRQKSRTLISNMEKNISAVDVEYLARATFEKSARAFMEETIKLGIRSRPKGLWGYYLYPDCHNYNFYPTNYTGSCPKEEVLRNDELSWLWNSSTALYPAVSIRKSFKDSEHTLHFSQYRVYESLRISTMTTHDYALPVFIYTRLGYREKPLLFLSKQDLISTIGESAALGAAGIVIWGDMNLTSSEENCTKVNHFVNSDFGNYIINVSTAAEVCSHHLCKNNGRCIRKTWNAPHYLHLNPASYHIEASEDGEFIVKGKASEEDLAVMAENFLCHCYQGYEGADCREMKEADSCSGVSLFSSSVITPCLLVLAGYQSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2MTQ3</accession>
    <name>A0A8C2MTQ3_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">Tekt1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035303129.1">
        <property type="nucleotide sequence ID" value="XM_035447238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2MTQ3"/>
    <dbReference type="Ensembl" id="ENSCGRT00001027112.1">
        <property type="protein sequence ID" value="ENSCGRP00001022867.1"/>
        <property type="gene ID" value="ENSCGRG00001021264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100759239"/>
    <dbReference type="KEGG" id="cge:100759239"/>
    <dbReference type="CTD" id="83659"/>
    <dbReference type="OrthoDB" id="10054259at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160111">
        <property type="term" value="C:axonemal A tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF25">
        <property type="entry name" value="TEKTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 11" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001022867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_035303129.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48733" checksum="A670C966E4393F23" modified="2022-01-19" version="1">MAKLLQSPPKFLPEEWYIANKSQYHRAEAQRCRSERLVAESQRLVDEIEKTTRKSQSDVNKKLEQRLEEVRFWKKELDNKLEQLVHETDDLLTYKVRLERSLESFKEPLHITERCLAYREQRVGIDFVQDVVDQELLKEADIIRGVMDLLKRTLEEMTEQIRLNRSAKYNLEKDLKDKFVALTIDDICFSLNNNSPNIKYSEDVVRIEPNSVSLEDWLDFSNANVEKADKQRNNSMTLKTLVDRILSQTANDLRRQCEVVDTAFVNGLKETKGARDKLADYLAKVMDEISSQEKNIAALENAILEQEGPAKVAHTRLETRTHRPNVELCRDIAQYRLIKEIQEINHNVARLKEILAQAQIELKALYRRQLALQEEIQVKENTIYIDEVLCMEMRKSIPPRDGDDHGAWEGGIRAEAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2N3F2</accession>
    <name>A0A8C2N3F2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-X-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">Cxcl9</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the intercrine alpha (chemokine CxC) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_003512801.1">
        <property type="nucleotide sequence ID" value="XM_003512753.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027244214.1">
        <property type="nucleotide sequence ID" value="XM_027388413.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2N3F2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001030492.1">
        <property type="protein sequence ID" value="ENSCGRP00001026246.1"/>
        <property type="gene ID" value="ENSCGRG00001023622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100770763"/>
    <dbReference type="KEGG" id="cge:100770763"/>
    <dbReference type="CTD" id="4283"/>
    <dbReference type="GeneTree" id="ENSGT00940000161751"/>
    <dbReference type="OMA" id="GKKYQKN"/>
    <dbReference type="OrthoDB" id="9948647at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048248">
        <property type="term" value="F:CXCR3 chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901741">
        <property type="term" value="P:positive regulation of myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051281">
        <property type="term" value="P:positive regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00273">
        <property type="entry name" value="Chemokine_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000004">
        <property type="entry name" value="C-X-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001089">
        <property type="entry name" value="Chemokine_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018048">
        <property type="entry name" value="Chemokine_CXC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033899">
        <property type="entry name" value="CXC_Chemokine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF210">
        <property type="entry name" value="C-X-C MOTIF CHEMOKINE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00436">
        <property type="entry name" value="INTERLEUKIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00437">
        <property type="entry name" value="SMALLCYTKCXC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00471">
        <property type="entry name" value="SMALL_CYTOKINES_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3 6" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044520794" description="C-X-C motif chemokine" evidence="6">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="8">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001026246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_027244214.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14052" checksum="971F31B0F984182C" modified="2022-01-19" version="1">MKSTVLFLLGIFLLDQCGVQGTLVIRNQRCSCIGTSQGTIPYRSLRDLKQFAPSPHCNKTEIIATLKSGTQTCLNPDSANVKKLMREWEKQISQKKKQKRGRKQQKNKKNRKAKKPKGPRAKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QC03</accession>
    <name>A0A8C2QC03_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calpain-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">Capn6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305952.1">
        <property type="nucleotide sequence ID" value="XM_035450061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QC03"/>
    <dbReference type="Ensembl" id="ENSCGRT00001000487.1">
        <property type="protein sequence ID" value="ENSCGRP00001000463.1"/>
        <property type="gene ID" value="ENSCGRG00001000367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100773921"/>
    <dbReference type="KEGG" id="cge:100773921"/>
    <dbReference type="CTD" id="827"/>
    <dbReference type="GeneTree" id="ENSGT00940000156128"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04046">
        <property type="entry name" value="C2_Calpain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000009">
        <property type="entry name" value="Calpain-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000131">
        <property type="entry name" value="calpain-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000064">
        <property type="entry name" value="calpain-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033884">
        <property type="entry name" value="C2_Calpain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF381">
        <property type="entry name" value="CALPAIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="13">
        <location>
            <begin position="26"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="498"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001000463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_035305952.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="74491" checksum="14D544E3143FC3C0" modified="2022-01-19" version="1">MGPPMKIFKNQKYQELKQECIKDGRLFCDPTFLPENDSLFFNRLLPGKVVWKRPQDISDDPHLIVGNISNHQLIQGRLGNKSMIPAFSCLAVQESHWTKTIPSHKDQEWDPQKPEKYAGIFRFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTVTDIIMDFTGTLAEIVDMQKGRYTDLVEEKYKLFGELYKTFTKGGLICCSIESPSQEEQEVETDWGLLKGHTYTMTDIRKLRLGERLVEVFSAEKLYMVRLRNPLGRQEWSGPWSEISEEWQQLTVTDRKNLGLVMSDDGEFWMSLEDFCHNFHKLNVCRNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRRFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRVFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEGLEKKYANETVNPYLIIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIIQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QCH1</accession>
    <name>A0A8C2QCH1_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho GTPase-activating protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Rho-type GTPase-activating protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">p190-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 23 24" type="primary">Arhgap5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23 24">17A/GY</strain>
            <tissue evidence="23 24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">GTPase-activating protein for Rho family members.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">May interact with RASA1/p120GAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_003512723.1">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QDZ8</accession>
    <name>A0A8C2QDZ8_CRIGR</name>
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        </submittedName>
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        <name evidence="9 12" type="primary">LOC113835001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027265091.1">
        <property type="nucleotide sequence ID" value="XM_027409290.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QDZ8"/>
    <dbReference type="Ensembl" id="ENSCGRT00001006934.1">
        <property type="protein sequence ID" value="ENSCGRP00001004607.1"/>
        <property type="gene ID" value="ENSCGRG00001005886.1"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12801"/>
            <dbReference type="Rhea" id="RHEA-COMP:13701"/>
            <dbReference type="Rhea" id="RHEA-COMP:13702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53904"/>
            <dbReference type="Rhea" id="RHEA-COMP:13703"/>
            <dbReference type="Rhea" id="RHEA-COMP:13704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297162.1">
        <property type="nucleotide sequence ID" value="XM_035441271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QFR7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001013143.1">
        <property type="protein sequence ID" value="ENSCGRP00001008979.1"/>
        <property type="gene ID" value="ENSCGRG00001011110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100769140"/>
    <dbReference type="CTD" id="9024"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021953">
        <property type="term" value="P:central nervous system neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090176">
        <property type="term" value="P:microtubule cytoskeleton organization involved in establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061178">
        <property type="term" value="P:regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14340">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000064">
        <property type="entry name" value="BR serine/threonine-protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048622">
        <property type="entry name" value="BRSK1_2-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF108">
        <property type="entry name" value="BR SERINE_THREONINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21122">
        <property type="entry name" value="KA1_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21115">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="346"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="682"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_035297162.1"/>
        </source>
    </evidence>
    <sequence length="735" mass="81714" checksum="A37FCC6CD2C53F11" modified="2022-01-19" version="1">MTSTGKDGGGAQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFINLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGEAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDQPSAQHLSDTTNCMEVMTGRLSKCGTPLSNFFDVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGGDTEYPMGKDMAKMGPPAAHREQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QHR0</accession>
    <name>A0A8C2QHR0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5">Cystin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">LOC113836605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_027280485.1">
        <property type="nucleotide sequence ID" value="XM_027424684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QHR0"/>
    <dbReference type="Ensembl" id="ENSCGRT00001016805.1">
        <property type="protein sequence ID" value="ENSCGRP00001012571.1"/>
        <property type="gene ID" value="ENSCGRG00001013951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113836605"/>
    <dbReference type="KEGG" id="cge:113836605"/>
    <dbReference type="GeneTree" id="ENSGT00390000016845"/>
    <dbReference type="OrthoDB" id="9450735at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058884">
        <property type="entry name" value="Cys1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26203">
        <property type="entry name" value="Cys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001012571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_027280485.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15505" checksum="CC0FADCCF445BFCD" modified="2022-01-19" version="1">MGSGSSRSGRIPRRRRSPDRRQAGPGEATSEGGTTDQAPTAATQETGRDPLPATPPSGREETLRLLDQLLAESEAWGPQEPTPRGPARLPPAVSPEKKTKDNSEDSCASEAPGSSHKRPEGQSAISYDYSEEELMASIEREYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QNB7</accession>
    <name>A0A8C2QNB7_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Growth factor receptor-bound protein 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GRB14 adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">Grb14</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
            <tissue evidence="22">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor, through the SH2 domain. Interacts with GRB14 (via BPS domain); this interaction protects the tyrosines in the activation loop on INSR from dephosphorylation. Binds to the ankyrin repeat region of TNKS2 via its N-terminus. Interacts with activated NRAS. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRB7/10/14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276108.1">
        <property type="nucleotide sequence ID" value="XM_027420307.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027295108.2">
        <property type="nucleotide sequence ID" value="XM_027439307.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QNB7"/>
    <dbReference type="Ensembl" id="ENSCGRT00001029327.1">
        <property type="protein sequence ID" value="ENSCGRP00001025081.1"/>
        <property type="gene ID" value="ENSCGRG00001022793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100752932"/>
    <dbReference type="KEGG" id="cge:100752932"/>
    <dbReference type="CTD" id="2888"/>
    <dbReference type="GeneTree" id="ENSGT00940000158609"/>
    <dbReference type="OrthoDB" id="5990423at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10414">
        <property type="entry name" value="SH2_Grb14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000015">
        <property type="entry name" value="Growth factor receptor-bound protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000714">
        <property type="entry name" value="Growth factor receptor-bound protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000133">
        <property type="entry name" value="growth factor receptor-bound protein 14 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015042">
        <property type="entry name" value="BPS-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035034">
        <property type="entry name" value="Grb14_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF22">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08947">
        <property type="entry name" value="BPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="Ras-associating" evidence="18">
        <location>
            <begin position="104"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="232"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="437"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001025081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_027276108.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60657" checksum="6DA9C7E36B4A720E" modified="2022-01-19" version="1">MTTSLQGGQSSAGRAAAQDSPLAVQVCRVAQGRGDAQDPARVPGLHPLSPSSDATRCGATDRRKKKDLDVLEMPSIPNPFPELCCSPLTSVLSAGLFPRANSRKKQVIKVYSEDETSRALEVPSDITARDVCQLLILKNHYVDDNSWTLFEYLSHTGVERIIEDHELVIEVLSHWGMEEENKLYLRKNYAKYEFFKNPMYFFPENMVSFAAETNGDRSPTQILQMFLSSSTYPEIHGFLHAKEQGKKSWKKVYCFLRRSGLYFSTKGTSKEPRHLQFFSEFSTSNVYVSVAGKKKHGAPTAYGFCFKPNKAGGPRDLRMLCAEEEQSRMCWVTAIRLLKHGMQLYQNYMHPYQGRSGCSSQSISPMRSISENSLVAMDFSGQKSRVIDNPTEALSVAVEEGLAWRKKGCLRLGNHGSPTAPSQSSAVNMAIHRSQPWFHHKISRDEAQQLIIRQGPVDGVFLVRDSQSNPRTFVLSMSHGQKIKHFQIIPVEDDGEMFHTLDEGHTKFTDLIQLVEFYQLNKGVLPCKLKHYCTRMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C2QPU2</accession>
    <name>A0A8C2QPU2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complement C1q subcomponent subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">C1qa</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="21">17A/GY</strain>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Core component of the complement C1 complex, a calcium-dependent complex composed of 1 molecule of the C1Q subcomplex, 2 molecules of C1R and 2 molecules of C1S. The C1Q subcomplex is composed 18 subunits: 3 chains of C1QA, C1QB, and C1QC trimerize to form 6 collagen-like triple helices connected to six globular ligand-recognition modules (C1q domain). Interacts with CR1 (via Sushi 24 and Sushi 25 domains). Interacts (via C-terminus) with CD33; this interaction activates CD33 inhibitory motifs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_035295195.1">
        <property type="nucleotide sequence ID" value="XM_035439304.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312559.1">
        <property type="nucleotide sequence ID" value="XM_035456668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C2QPU2"/>
    <dbReference type="Ensembl" id="ENSCGRT00001032442.1">
        <property type="protein sequence ID" value="ENSCGRP00001028194.1"/>
        <property type="gene ID" value="ENSCGRG00001024982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100766409"/>
    <dbReference type="KEGG" id="cge:100766409"/>
    <dbReference type="CTD" id="712"/>
    <dbReference type="GeneTree" id="ENSGT00940000162143"/>
    <dbReference type="OMA" id="MEGPQGW"/>
    <dbReference type="OrthoDB" id="6343173at2759"/>
    <dbReference type="Proteomes" id="UP000694386">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005602">
        <property type="term" value="C:complement component C1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062167">
        <property type="term" value="C:complement component C1q complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098890">
        <property type="term" value="C:extrinsic component of postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098888">
        <property type="term" value="C:extrinsic component of presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106139">
        <property type="term" value="C:symbiont cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019864">
        <property type="term" value="F:IgG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001791">
        <property type="term" value="F:IgM binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048143">
        <property type="term" value="P:astrocyte activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150062">
        <property type="term" value="P:complement-mediated synapse pruning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001774">
        <property type="term" value="P:microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150064">
        <property type="term" value="P:vertebrate eye-specific patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000001">
        <property type="entry name" value="Complement C1q B chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF26">
        <property type="entry name" value="COMPLEMENT C1Q SUBCOMPONENT SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044679334" description="Complement C1q subcomponent subunit A" evidence="16">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="17">
        <location>
            <begin position="110"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSCGRP00001028194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_035295195.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="25866" checksum="6CDB2A2F92CD859D" modified="2022-01-19" version="1">MEASWGWLVACVLAMTLVSTVTEDVCRAPNGKDGVAGNPGRPGRPGPKGERGEPGAAGIRTGIRGLKGDQGESGPPGKPGNMGFPGPTGPLGSSGPQGLKGVKGNPGNIRDQPRPAFSAIRQNPPTVGNVVIFDKVITNEEGPYQNKTGRFICAVPGFYYFTFQVTSKWDICLSIMFSSHGQTRSPLGFCDANSKGLFQVVSGSTVLHLQRGDQVWIEKDPAKGRIYQGTEVDSIFSGFLIFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F1A6</accession>
    <name>A0A9J7F1A6_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Polycystin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Transient receptor potential cation channel subfamily P member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">LOC100771469</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="35" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="36">17A/GY</strain>
            <tissue evidence="36">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027244284.1">
        <property type="nucleotide sequence ID" value="XM_027388483.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F1A6"/>
    <dbReference type="GeneID" id="100771469"/>
    <dbReference type="KEGG" id="cge:100771469"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002133">
        <property type="term" value="C:polycystin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071498">
        <property type="term" value="P:cellular response to fluid shear stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:chordate embryonic development"/>
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        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
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                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
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            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
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        <scope>IDENTIFICATION</scope>
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            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027250532.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="20943" checksum="CD132C12C62D67CA" modified="2023-06-28" version="1">MGSGLVACRGAPDQAVFTAFPRSLRAAEDHQPVSDTGPSSPPAAVRAQAREPALTTFAHEVAPHQTQRRTAAHAPFPIIHLERARGAPRPFASLRPHFTAAPESHGANPARRAVALRRHRPPPRQLGERPSSPSLIGRSLCQSPQASGAQRAAGGSARGCAAAEVSPEEDASLVAAQDGAESPHAGGAEEWGDIQWAPGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7F661</accession>
    <name>A0A9J7F661_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein C12orf73 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">C1H12orf73</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UQCC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_007644530.1">
        <property type="nucleotide sequence ID" value="XM_007646340.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027248344.1">
        <property type="nucleotide sequence ID" value="XM_027392543.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7F661"/>
    <dbReference type="GeneID" id="100773036"/>
    <dbReference type="KEGG" id="cge:100773036"/>
    <dbReference type="CTD" id="120979266"/>
    <dbReference type="OrthoDB" id="6139781at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027858">
        <property type="entry name" value="BRAWNIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28492">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC691921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28492:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14990">
        <property type="entry name" value="DUF4516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_027248344.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18754" checksum="30E692528E176B8D" modified="2023-06-28" version="1">MRQDGAVTRSRMAKAWKRSRQNKSRKIKTLRLTAGRNTRMRTRAHFPRFPLRRGAGPLHFGSGPWRSAPYRAGTSGRPGPVHSPLCTMPGGVPWSAYLKMLSSSLLAMCAGAQVVHWYYRPDLVMLSSKRPQSEGQCNLHVPSTSHQHQLAFQLLECYIRCHDAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FPW8</accession>
    <name>A0A9J7FPW8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hyaluronoglucosaminidase</fullName>
            <ecNumber evidence="5">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Cemip</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEMIP family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027263367.1">
        <property type="nucleotide sequence ID" value="XM_027407566.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100760429"/>
    <dbReference type="KEGG" id="cge:100760429"/>
    <dbReference type="CTD" id="57214"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd13938">
        <property type="entry name" value="PANDER_like_TMEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052252">
        <property type="entry name" value="CEMIP/CEMIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055400">
        <property type="entry name" value="CEMIP_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019316">
        <property type="entry name" value="G8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039473">
        <property type="entry name" value="TMEM2_PANDER-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535:SF15">
        <property type="entry name" value="CELL MIGRATION-INDUCING AND HYALURONAN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24605">
        <property type="entry name" value="CEMIP_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10162">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01225">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51484">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G8" evidence="16">
        <location>
            <begin position="67"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_027263367.1"/>
        </source>
    </evidence>
    <sequence length="1384" mass="155469" checksum="79D9611CFE439CF5" modified="2023-06-28" version="1">MLHSRSPRRGTVSGINRREHAVGLRAAGRHHVSLKVVLAMGWLLLVDFSAATSAVAAECPDQNPELQPWTPGHDRDHQVHIGQGRSLLLTSSATVHSITISQGGKLVIKDHHEHIVLRARHILIDYGGELHAGSALCPFEGNFSIVLYGRADEGIQPDPYYGLKYIGVGRGGTLELHGQKKLSWTFLNKTLRPGGMQEGGYFFERSWGHRGVIVHVIDPKSGTVVHSDRFDTYRTKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFRHPWSFITVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEHFNVSSTSEWVQDVEWTEWFSHDKVPQSKGGEKISDLRAAYPGKICNRPIDIQATTMDGVALSTEVVYKNGQDYRFACYTRGRACRSYRVRFLCGKPVRPKLTVSIDTNVNSTILSLADNVQSWRPGDTLVVASTDYSMYQAEEFQVLTCKACSSTQVRVAGKPQYLHIGEEIDGVDMRAEVGLLTRNIVVMGEMEDQCYPYTSHICDFFDFDTFGGHIKFALGFKAAHLEGVELKYMGQQLVGQYPIHFHLAGDLDEKGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSRMCKVITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFHNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFTAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKSSNLRMKIIKNDFPSHPLYLEGALTRSTHYQQYQPVITLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGTFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSMKGCERIKIKALIPRNAGISDCTATAYPRFTERAVVDVPMPKKLVGTQLKTKDHFLEVKMESSRQHYFHLRNDLAYIEVDGRKYPCSEDGIQVVVIDGNRGHVVSHGSFRNAILQGIPWQLFNYVAAIPDNSIILMASKGRYVTRGPWTKVLEKLGADKGLKLKEKMVFVGFKGSFRPTWVTLETEEHKAKIFQVVPIPVVRKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FR72</accession>
    <name>A0A9J7FR72_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glutathione S-transferase</fullName>
            <ecNumber evidence="16">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GST class-pi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC100757534</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate</text>
            <dbReference type="Rhea" id="RHEA:50260"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:132200"/>
            <dbReference type="ChEBI" id="CHEBI:132201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:50261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50800"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133370"/>
            <dbReference type="ChEBI" id="CHEBI:133769"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50804"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133396"/>
            <dbReference type="ChEBI" id="CHEBI:133771"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:50805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:50808"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133396"/>
            <dbReference type="ChEBI" id="CHEBI:133772"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50809"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Interacts with CDK5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the GST superfamily. Pi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="16"/>
    <dbReference type="RefSeq" id="XP_003509973.2">
        <property type="nucleotide sequence ID" value="XM_003509925.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027264538.1">
        <property type="nucleotide sequence ID" value="XM_027408737.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FR72"/>
    <dbReference type="GeneID" id="100757534"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03076">
        <property type="entry name" value="GST_N_Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000047">
        <property type="entry name" value="Glutathione S-transferase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000071">
        <property type="entry name" value="Glutathione S-transferase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000392">
        <property type="entry name" value="Glutathione S-transferase pi 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003082">
        <property type="entry name" value="GST_pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF248">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01268">
        <property type="entry name" value="GSTRNSFRASEP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="17">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="18">
        <location>
            <begin position="95"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027264538.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25532" checksum="2DE5D5FAFACF9B74" modified="2023-06-28" version="1">MLLKLHRTASPKMPPYTIVYFPSRGRCEVMRMLLADQGQSWKEEVVTLDAWEQGTLKASCLFGQLPKFQDGDITLYQSNAILRHLGRSFGLYGKDQKEAALVDMVNDGLEDLIRHLGQQLLRNYEEGKVQYLKELPRHLKPFETLLAQNKGGQSFIVGDQISFADYRLLDLLLNHERLFPGYLNDFPMLSAYVTRLRARPKLKAFLDSPEHVNRPISARLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FSH5</accession>
    <name>A0A9J7FSH5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Tyrosine-protein kinase transmembrane receptor ROR2 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">Ror2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
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                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
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            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23">17A/GY</strain>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
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        <property type="entry name" value="Frizzled_dom_sf"/>
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    <dbReference type="InterPro" id="IPR007110">
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF132">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
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        <property type="entry name" value="IGc2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FZ"/>
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        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="23" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 15" id="KW-0420">Kringle</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="23" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 17 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="324"/>
            <end position="414"/>
        </location>
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        <location>
            <begin position="438"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="20">
        <location>
            <begin position="584"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="742"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="166"/>
            <end position="266"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="1026"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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        </location>
    </feature>
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        <location>
            <begin position="1160"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
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            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
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            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
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            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1171"/>
            <end position="1180"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_027265692.2"/>
        </source>
    </evidence>
    <sequence length="1212" mass="133865" checksum="E8E546CCA1FBB163" modified="2023-06-28" version="1">MWMLSDPEAAANRKEDGYPQSRLPRPWASPKWDIYTTLLPNTQGICWKKGQKELLEYPTPLVVDTLFHANYIATVTNSNLQSPLGGLGRAPVGTRPFVFGNICAKSTPHFLHILPRISNEFPSWSSKAWREGGGERLGLGQHRGFGQGSFPRGGVAALESLRQRAPAPASLPIGAGEPGTLPPARPPAFRPPRLSRRPAGRPSPLSGASAAERRLGAGRKGRQGGLRRKQLVKRRGGKRGRVAGRGGGALARSPKAERSAGDPAPMARSVARGWVRPMRAPLCARAIWTAAALLLWTPWTAGEVEDSDAIDILGQLDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQDDYQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRVPKPRELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPLPESPDAANCMRIGIPAERLGRYHQCYNGSGADYRGMASTTKSGHQCQPWALQHPHSHHLSSTEFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPPCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRGRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYMAPKQKAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLAEGTEDAQNMPEEVAQSPVQEAAEEEEGSVPETELLGDNDTLPVNEAHVQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FT05</accession>
    <name>A0A9J7FT05_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DENN domain-containing protein 5A isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Dennd5a</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAB6IP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027266114.1">
        <property type="nucleotide sequence ID" value="XM_027410313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100767226"/>
    <dbReference type="KEGG" id="cge:100767226"/>
    <dbReference type="CTD" id="23258"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01757">
        <property type="entry name" value="PLAT_RAB6IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17690">
        <property type="entry name" value="RUN1_DENND5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17692">
        <property type="entry name" value="RUN2_DENND5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000003">
        <property type="entry name" value="DENN domain containing 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000008">
        <property type="entry name" value="DENN domain containing 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000001">
        <property type="entry name" value="DENN domain containing 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000007">
        <property type="entry name" value="DENN domain-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047278">
        <property type="entry name" value="DEN5A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047277">
        <property type="entry name" value="PLAT_RAB6IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047294">
        <property type="entry name" value="RUN1_DENND5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047295">
        <property type="entry name" value="RUN2_DENND5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070:SF2">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="UDENN" evidence="10">
        <location>
            <begin position="207"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="11">
        <location>
            <begin position="937"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_027266114.1"/>
        </source>
    </evidence>
    <sequence length="1437" mass="162769" checksum="856FB13F970CBDF5" modified="2023-06-28" version="1">MSQFYPHGPLFPPPLFPPPQSSKGRRSPVRAAGVAGSRRPPLATLRRLLWKPRPPEPKEHHVILCARRPPLPNRACARGGGGGGGGGAAGGGARGGADSRSPPFLRLARPRRGGPRPGCGSGWPSAPLPRHGNGGCWDPRRRRERRPRAAAERGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGNLHCSESASKLKRIRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSNSGILLDSERRKSDASAVMSPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTAINNTSRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FVZ9</accession>
    <name>A0A9J7FVZ9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Olfactory receptor 147</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC100772488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027268025.1">
        <property type="nucleotide sequence ID" value="XM_027412224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FVZ9"/>
    <dbReference type="GeneID" id="100772488"/>
    <dbReference type="KEGG" id="cge:100772488"/>
    <dbReference type="OrthoDB" id="9609126at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="46"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_027268025.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35279" checksum="570D5C1A8DD8966D" modified="2023-06-28" version="1">MIQRRMALGNDSSVKEFILLGLTQQPELQLPLFFLFLAIYVVSMVGNLGLIILIVLNPHLHTPMYYFLFNLSFTDLCYSSVITPKMLVSFVKQNIISHTECMTQLFFFCFFVIDECYILTAMAYDRYAAICKPLLYKVTMSYQVCHLMTVGVYAMGFVGAMAHTGSMLSLTFCNGNIINHYMCDIPPLQKLSCTSTAINELVVFIVVGVNVIVPSLTIFISYTLILYNILSIHSAESRSKAFSTCGSHVIAVSLFFGASAFMYLKPSNTSVDDDKISTIFYTIVGPMLNPFIYSLRNKDVHIALRKALKKTVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FWA3</accession>
    <name>A0A9J7FWA3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription cofactor vestigial-like protein 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Vgll3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a specific coactivator for the mammalian TEFs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the vestigial family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027268223.1">
        <property type="nucleotide sequence ID" value="XM_027412422.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7FWA3"/>
    <dbReference type="GeneID" id="100762839"/>
    <dbReference type="KEGG" id="cge:100762839"/>
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    <dbReference type="OrthoDB" id="10069705at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF16">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="78"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_027268223.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36043" checksum="76569831651EB894" modified="2023-06-28" version="1">MSCAEVMYHPQPYGAPQYLPNPVAAATCPTACYHPAPQPGQQKKLAVYSKMQDSLEVTLPSKQEEEEEEEDEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDEHFSRALGQASTLHPESAISKSKMGLTPLWRDSSALSSQRSNFPASFWTSSYQPPPAPCLGGVHPDFQVTAPHGTFATADPNSWPGHGLHQTGPAPPPTASESWHYPLASQVSPSYSHMHDVYMRHHHPHAHMHHRHHHHHHHPTAGSALDPAYGPLLMPSVRTARIPAPQCDITKTDPTTVTTATSAWAGAFHGTVDIMPSVGFDTGLQHQDKSKESAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7FZN0</accession>
    <name>A0A9J7FZN0_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: coiled-coil domain-containing protein 85C isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Ccdc85c</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC85 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027272158.1">
        <property type="nucleotide sequence ID" value="XM_027416357.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100769004"/>
    <dbReference type="KEGG" id="cge:100769004"/>
    <dbReference type="CTD" id="317762"/>
    <dbReference type="OrthoDB" id="10056395at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019359">
        <property type="entry name" value="CCDC85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 85C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546">
        <property type="entry name" value="RE60986P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10226">
        <property type="entry name" value="CCDC85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_027272158.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="45500" checksum="C7ECBBAADF87B748" modified="2023-06-28" version="1">MAKPPAVAAAAAAAAAASEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQDDNQELRELCCFLDDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLLLDEERAALAAAGGAGGSGGGXGSRSSIDSQASLSGPLAGSAAGSGTRDVGDGSSTSSAGSGGSPDHHHHVPPALLPPGPHKGPDGKAGATRRSLDDLSAPPHHRSIPNGLHDPSSTYIRPLETKAKLLEGDKLPPQQAGSGEFRTLRKGFSPYHSESQLASLPPSYQEVLQNGPACPVAELPSPPPAVYSSAGQKPEAVVHAMKVLEVHENLDRQLQDSCEEDLSEKEKAIVREMCNVVWRKLGDAASTKPSIRQHLSGNQFKGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G2U0</accession>
    <name>A0A9J7G2U0_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-MNLL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase MNLL subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100754039</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB1 subunit family.</text>
    </comment>
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    <dbReference type="KEGG" id="cge:100754039"/>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="NDUB1"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH_oxidored"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="6" id="KW-0813">Transport</keyword>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027274955.1"/>
        </source>
    </evidence>
    <sequence length="62" mass="7513" checksum="98F241D585C19F3A" modified="2023-06-28" version="1">MQAAIMTLLQLVRDHWVHILVPMGFAFGYYLDKRADEKLTTFRNKSMLFRRELRPNEEVTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G4L1</accession>
    <name>A0A9J7G4L1_CRIGR</name>
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        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC100770068</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276883.1">
        <property type="nucleotide sequence ID" value="XM_027421082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7G4L1"/>
    <dbReference type="GeneID" id="100770068"/>
    <dbReference type="KEGG" id="cge:100770068"/>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="42"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_027276883.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35673" checksum="462EAFAA64702ADA" modified="2023-06-28" version="1">METMQNLSFVTEFVFVGLSQNPNIQRLMFIICFLVYIVTVGSNMMIVVTIICSPKLLDSPMYFFLVFLSLLDASFCSVMTPKMTVDSLYKRKIISFKGCMIQLFAAHFFGGAEMIVLTAMAYDRYVAICKPLHYSSIMTRRLCVTLVGVAWAGGLLHSTVQIIFTLQLPFCGPNVIDHFMCDLFPLLELACTDTHIFGLLVIANSGFICIIVFFLLLVSYGFILLSLRFHSSEGRWKALSTCGSHIAVVVLFFVPCTFIYARPHTGSSFDKMIALFYTMLSPFLNPMIYTFRNKDMKNAMWELWKKLIMVSNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7G5J1</accession>
    <name>A0A9J7G5J1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">LOW QUALITY PROTEIN: olfactory receptor 5W2-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC100760651</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="17">17A/GY</strain>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027276944.1">
        <property type="nucleotide sequence ID" value="XM_027421143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="100760651"/>
    <dbReference type="KEGG" id="cge:100760651"/>
    <dbReference type="OrthoDB" id="9575991at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="40"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_027276944.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35397" checksum="28B753687FA42E51" modified="2023-06-28" version="1">MEVGNCSATEFLFLGITNNPVIKVILFTTFLYIYLLALCENHGIIILIRVDQQLHTTMYFFLSHLSFCDVCYSTAVCPKMLVELLAKSSNSIPFLRCVLQFFIFCIFTDVEYMLLAMMAFDQYKAISNPLLYAVDMSSKVCYQLLAVVYLVGIVDAVIHTTLTLRLSFCGSKDINLFFCDLPLLYLLWCSDIQVNELALFTVFGFIELSAIXGVLVSYCYILLSVLKIHSAEGRFKAFSICTSHLTAVAIFQGTMLFMYFWPSFSYSLDQDKMTSVFYTLVIPMLNPLVYSPRNKDVKEALQKLKTKTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GCY9</accession>
    <name>A0A9J7GCY9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="17">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Nme4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homohexamer. Interacts with OPA1. Interacts with CAPN8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion intermembrane space</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15 16">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="17"/>
    <dbReference type="RefSeq" id="XP_027280926.1">
        <property type="nucleotide sequence ID" value="XM_027425125.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GCY9"/>
    <dbReference type="GeneID" id="100757593"/>
    <dbReference type="KEGG" id="cge:100757593"/>
    <dbReference type="CTD" id="4833"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000017">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="18">
        <location>
            <begin position="35"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="15">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_027280926.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20487" checksum="D5053C50444ECF62" modified="2023-06-28" version="1">MGSLFGRAALRALLCGPRIPGLLVRPRSGGPSWPQERTLVAVKPDGVQRRLVGTVIERFERRGFKLVGMKMLQAPESILAEHYRDLQRKPFYPALISYMSSGPVVAMVWEGHNVVRISRTMIGHTDSTEAAPGTIRGDFSIHISRNIIHASDSVEGAQREIQLWFKSSELLNWADDGHPSSCCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GD34</accession>
    <name>A0A9J7GD34_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Adenylate cyclase type 9</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">ATP pyrophosphate-lyase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Adenylate cyclase type IX</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Adenylyl cyclase 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">Adcy9</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="28">17A/GY</strain>
            <tissue evidence="28">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 29">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_027279823.1">
        <property type="nucleotide sequence ID" value="XM_027424022.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027295066.1">
        <property type="nucleotide sequence ID" value="XM_027439265.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100751372"/>
    <dbReference type="KEGG" id="cge:100751372"/>
    <dbReference type="CTD" id="115"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000008">
        <property type="entry name" value="Adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000014">
        <property type="entry name" value="adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF8">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="26">
        <location>
            <begin position="395"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="26">
        <location>
            <begin position="1078"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_027279823.1"/>
        </source>
    </evidence>
    <sequence length="1373" mass="153383" checksum="336D84D4BB8E18E4" modified="2023-06-28" version="1">MASSPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNTHPKHCKYSISSSCSSSGDSGGLPRRMGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAVHMRSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVWTPLLGRVDSSNQTLIAKAAADTCLSQVGLFSMCIEVLFLLYTVMHLPLYLSLFLGVAYSVLFETFGYHFRNEDCFPSPGPGALHWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHTTSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVIERLGQSVVADQLKGLKTYLISGQRAKESHCSCAEALLSGFEVIDGSRASSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPACGITFAPKSEAGAEGGAVQNGCQDEPKTGTKVTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLLSPPPEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITCFLKYAATATPPPPAALAVFGADLLLEVLSLVVSIRMVFFLEDVMVCTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHITSEFETNIHFTMFTGSAVLVAVVHYCNFCQLSSWMRSSLATIVGAGPLLLLYISLCRDSSIVISPLDTAQNFSANRNPCNSSLLQDSRRPASLIGKELALTFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCMDNGVVPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYTDKTSLGSDDNTQAKEVHLSCKRPWREPVKAEERFRFGKAIEKDDCEDTGIEEANELTKLNVSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GFN9</accession>
    <name>A0A9J7GFN9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger matrin-type protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC113837078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027285362.1">
        <property type="nucleotide sequence ID" value="XM_027429561.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027293406.1">
        <property type="nucleotide sequence ID" value="XM_027437605.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GFN9"/>
    <dbReference type="GeneID" id="113837078"/>
    <dbReference type="KEGG" id="cge:113837078"/>
    <dbReference type="OrthoDB" id="9604311at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46742:SF1">
        <property type="entry name" value="LYSINE RICH COILED-COIL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46742">
        <property type="entry name" value="LYSINE-RICH COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027285362.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21877" checksum="C6F3275D50F1A599" modified="2023-06-28" version="1">MEKPQTNDSFQCELEDFIRKQKARGLNPRVYFRNKAENSVHQERDHVSSGAPMFSFREHPRPSYEGLAGENLAPHSRPRLEYLRHQNQPVNQDRKEKTWHQEQGGGTNAEPGMAERKHHRERGSLKDRSLSRKKASADPLGTEKSKHRKGTSHDRRDTTRGRHHSHRKKKEPEERDLWDEAILGSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMI7</accession>
    <name>A0A9J7GMI7_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC113837972</name>
        <name evidence="3" type="synonym">LOC113837971</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3 4">17A/GY</strain>
            <tissue evidence="3 4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_027289579.1">
        <property type="nucleotide sequence ID" value="XM_027433778.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027289580.1">
        <property type="nucleotide sequence ID" value="XM_027433779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GMI7"/>
    <dbReference type="GeneID" id="113837972"/>
    <dbReference type="KEGG" id="cge:113837971"/>
    <dbReference type="KEGG" id="cge:113837972"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_027289579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_027289580.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30149" checksum="612C0B75E9418A9A" modified="2023-06-28" version="1">MMAGKHIVEDQIEEEYSLFGGSDKLKPLRDTLMGGLYGDHLKTPGSEEGFATQRDEGKYQEGPEEHTDTCNARRFWGEGSSPVAAPDPWFSLAGFYAFGISQTLMNKTSWPISCWSTESLPEAFPCLNISSCLVCLWTWGNTSSCQEVQSQYPVARAASALSCLKGFQPPDNSGSPAVAVDTLSHCPQEGGRRAGANSTRAMGRGHQSGSPSGQASGSSQWGSLPPPSPALQPLPPSPTPDVELQSHCPNISVPQARACRHRPCARPRPHPRLRLHLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GMW9</accession>
    <name>A0A9J7GMW9_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Granulocyte colony-stimulating factor receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Csf3r</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294803.1">
        <property type="nucleotide sequence ID" value="XM_035438912.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035310743.1">
        <property type="nucleotide sequence ID" value="XM_035454852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GMW9"/>
    <dbReference type="GeneID" id="100760185"/>
    <dbReference type="KEGG" id="cge:100760185"/>
    <dbReference type="CTD" id="1441"/>
    <dbReference type="OrthoDB" id="9887129at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030666">
        <property type="term" value="C:endocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019955">
        <property type="term" value="F:cytokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000879">
        <property type="entry name" value="Colony stimulating factor 3 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001209">
        <property type="entry name" value="Colony stimulating factor 3 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001234">
        <property type="entry name" value="Colony stimulating factor 3 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000997">
        <property type="entry name" value="Colony stimulating factor 3 receptor (Granulocyte)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000465">
        <property type="entry name" value="Granulocyte colony-stimulating factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000839">
        <property type="entry name" value="granulocyte colony-stimulating factor receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003529">
        <property type="entry name" value="Hematopoietin_rcpt_Gp130_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010457">
        <property type="entry name" value="IgC2-like_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052672">
        <property type="entry name" value="Type1_Cytokine_Rcpt_Type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423:SF1">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06328">
        <property type="entry name" value="Lep_receptor_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01353">
        <property type="entry name" value="HEMATOPO_REC_L_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039907546" description="Granulocyte colony-stimulating factor receptor" evidence="17">
        <location>
            <begin position="26"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="229"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="334"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="434"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="530"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035294803.1"/>
        </source>
    </evidence>
    <sequence length="842" mass="94638" checksum="F068C3FB81F6EA33" modified="2023-06-28" version="1">MVGLGACTLTGAALILLLLPKSLESCGHIRISVPVVRLGDPVIASCTISPNCSKLDQESQILWRLQDGPNQPGDRQRRLPDGSQESTITLPHVNHTKAFLSCLVPWANSFQVLDQAELQAGYPPASPSNLSCLMYLTTNSLVCQWEPGPETYLPTNFTLKSFRSRDDCQYQKDSILDCVPEDGQNTCSIARKHLILYQNMVIWVQAKNMLGTSESPKLCLDPMDVVKLEPPVLQAVDISPDLIPYQPGCLWLSWKPWKPGEYIEQECELRYRPQLRRANWTLVSHLPSSEDQFKLCGLHQAPVYTLQIRCIRSPLPGLWSSWSPGLHLRPTMKAPTIRLDTWWQKKQLDPWTESVQLFWKPTPLQEDSGEIQGYLLSWSPSDQQGPVRHLCNTTELSCIFYLPSEAQNVNLMAYNTGGTSLPTPVVFLENKGPAVSRLHAMAQDPDSIWVDWEVPSTMPQGYLIEWCQRSLSHNYSSKTWRMEPDGSITGILLQENISPFELYEIMVAPLYPGIVGPPVKVYAYSGERALPHAPELHLKQVGSTWAQVEWIPETPWLGMIPLTHYTVFWTDDQNQTFSIILNISFHGYVLDHLEPARLYHVYLMATSRAGSSNSTGLTLMTLALETSELHVFLGLLVFLISFVSFCGTVWFCCKNSRTKFFWPNVPDPAHSSLSSWVPTIMTEETFQLPSLWDSSMPPITKITVLEEEKKLTNWDSGDNSLTSSLPTLVQAYVLQGDPRATSNQFQPSSGTSDQVLYGQVLGSPTSPGVMRYLRCDSTQPLLGGLTPSPKSYENIWFHPRPQETFVSQPPNQEDDDCVFGPPIDFPLFQGLQVHGVEEQEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GN66</accession>
    <name>A0A9J7GN66_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Speckle-type POZ protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC113833825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="9">17A/GY</strain>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035294811.1">
        <property type="nucleotide sequence ID" value="XM_035438920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GN66"/>
    <dbReference type="GeneID" id="113833825"/>
    <dbReference type="KEGG" id="cge:113833825"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000003">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="189"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_035294811.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40433" checksum="4520B4FEC5C30DE9" modified="2023-06-28" version="1">MTEDGAAERWGYTEISVQKFSYSWTISNFRFLLQEVEEAIKSPPFSSGSSVNDKWCLKVRTNGIEEDGQDYLSVHLTLLSCPKSPVRARLQFWIRSVDGEKTNGMITPGFLKFTPNQHWGFTKFIHRDLLLSLESWLLPDNELTVLCDVDLAVQDSLINSKASKVPGILVPRSTVADDLGQLWENSVFTDCSLVVAGQEFGAHKAILAARSPVFRAMFEKDMEESRKNRVEILDLELQVFKAMMEFIYTGKAPDLHSMADAVLAAADKYGLEHLKVMCEDVLCRDLSVENAAHTLILADLHSAGQLKTKALDFITAHASEVSETSSWKKMVGSHPHLLAEAFSSLASAHSTLLGPPPKRFKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GPD5</accession>
    <name>A0A9J7GPD5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LOW QUALITY PROTEIN: GTPase ERas isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC100763084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_027289860.2">
        <property type="nucleotide sequence ID" value="XM_027434059.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100763084"/>
    <dbReference type="KEGG" id="cge:100763084"/>
    <dbReference type="OrthoDB" id="9835289at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_027289860.2"/>
        </source>
    </evidence>
    <sequence length="230" mass="25262" checksum="1CBD62363B9BAC62" modified="2023-06-28" version="1">MALPTKSSILDLCLNTQCTRYPKESHDGWAKCKDSGRKLPKYKIVVLGASGVAKSALTIQMSHQCFVEEHDPTIQDSYWKEVALDNSSFYILNVLDTAGQDIYRDLXDQCLAAGDGVLGVFALDDPSSLDQLQQIWSTWSLQQKQPPLVHVGNKCDLVTASGDAHTDAAIITHNWRVPFIKTSAKTGQGIEEAFALLVHEIQRAQESVVESSMEKTRQHKAVCSCGCSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GQ65</accession>
    <name>A0A9J7GQ65_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Rhomboid-related protein 4</fullName>
            <ecNumber evidence="5">3.4.21.105</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Rhomboid domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Rhomboid-like protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 24 25" type="primary">LOC100756292</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="23 24 25" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="23 24 25">17A/GY</strain>
            <tissue evidence="23 24 25">Liver</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="5"/>
    <dbReference type="RefSeq" id="XP_035296949.1">
        <property type="nucleotide sequence ID" value="XM_035441058.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296950.1">
        <property type="nucleotide sequence ID" value="XM_035441059.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035296951.1">
        <property type="nucleotide sequence ID" value="XM_035441060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GQ65"/>
    <dbReference type="GeneID" id="100756292"/>
    <dbReference type="KEGG" id="cge:100756292"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051247">
        <property type="term" value="P:positive regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000009">
        <property type="entry name" value="Rhomboid domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF14">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="21">
        <location>
            <begin position="63"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_035296949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_035296950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_035296951.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38351" checksum="9FE5A0D01C1B4E75" modified="2023-06-28" version="1">MQRRSRGINVGLLMLLSQVVHVGINNIPPVTLATLALNIWFFLNPLKPLYYSCISVEKCYQQKDWQRLLLSPLHHADDWHLYFNMVSMLWKGIKLERRLGTRWFAYLITTFSLLTGVVYLVLQFTLAELMNQPDFRRNCAVGFSGVLFALKVLSNHYFPGGFVNVLGFLVPNRLACWAELVAIHFCTPGTSFAGHLAGILVGLMYTQGPLKKIMETCAGIFSSTVGYPGQQYYFNSAGPSGYQNHYPDGRPRAYEDTHRNYDVYTAGLSEEEQLERALRASLRDRALDWRKVWLGGVVAQGVPDTVGSERKYQKWSNTLRVPTHARRRNEETAPPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GTD4</accession>
    <name>A0A9J7GTD4_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.244</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">B4galnt4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61631"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:138027"/>
            <dbReference type="EC" id="2.4.1.244"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.244" evidence="10"/>
    <dbReference type="RefSeq" id="XP_035292953.1">
        <property type="nucleotide sequence ID" value="XM_035437062.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035298011.1">
        <property type="nucleotide sequence ID" value="XM_035442120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GTD4"/>
    <dbReference type="GeneID" id="100758404"/>
    <dbReference type="KEGG" id="cge:100758404"/>
    <dbReference type="CTD" id="338707"/>
    <dbReference type="OrthoDB" id="5971499at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000063">
        <property type="entry name" value="Beta-1,4-N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF46">
        <property type="entry name" value="N-ACETYL-BETA-GLUCOSAMINYL-GLYCOPROTEIN 4-BETA-N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="63"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="576"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035298011.1"/>
        </source>
    </evidence>
    <sequence length="986" mass="111956" checksum="F0366C8A1CAC1B74" modified="2023-06-28" version="1">MPLADGEKLTGVTDSRGVRLVSSTQRAEDSSESHEEEQAPEGRVPNMLFPGGARKPPPLNLTHQTPPWREEFKGQVNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVTKLAVSPKWKNYGLRIFGFIHPARDGDIQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASRRYYFELLHKQDDKGSDHVEVGWRAFLPGLKFEIIGSAHISLYTDESSLKMDHVTHVPQSPASHVGGYPPHEEPSADMLQPDPRDTFFLTPRMEPLSLENVLEPCAYAPTYVLKDFPIARYQGLQFVYLSFIYPNDHTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGEEDEEIQRRAFLFLNPDDFLDDEDEQELLDSLEPTDASLRQSHKTPTPTASPGTTDTPTLPMTSPLDEQTPRHSRALNWASRSLPLFLGRAPPPRTVEKSPSKVYVTRVRPGQRTSPRALRDSPWPPFPGIFLHPKPLPRVQLRTPPHPPRTQGYRTSGSKVTELKPPVRAKTTQGGQEGQLHGQGLMVPTVDLNSSAETQPVTSFLSLSQVSRPQLPGEGEEGEDDGAPGDEATSEDSEEEEEQAAGRPMGRWREDAINWQRTFSVGAMDFELLRSDWNDLRCNVSGNLQLPEAEAVDVVAQYMERLNARHGGRFSLLRIVNVEKRRDSARGSRFLLELELQERGGSRQRLSEYVFLRLPGARIGDEYGESPEPPPAASIRPDSRPELCRPLHLAWRQDVMVHFIVPVKNQARWVVQFLADMTALHVRTGDSNFNIILVDFESEDMDVERALRVAQLPRYQYLKRTGNFERSAGLQTGVDAVEDPSSIVFLCDLHIHFPPNILDSIRKHCVEGKLAFAPVVMRLGCGSSPWDPHGYWEVNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRHFYHHYHSKRGMWTTRSHKGTRTQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GV34</accession>
    <name>A0A9J7GV34_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prostatic steroid-binding protein C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC100751230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the secretoglobin family. Lipophilin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035297478.1">
        <property type="nucleotide sequence ID" value="XM_035441587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GV34"/>
    <dbReference type="GeneID" id="100751230"/>
    <dbReference type="KEGG" id="cge:100751230"/>
    <dbReference type="OrthoDB" id="9535440at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00633">
        <property type="entry name" value="Secretoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016126">
        <property type="entry name" value="Secretoglobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053723">
        <property type="entry name" value="Secretoglobin_Domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035960">
        <property type="entry name" value="Secretoglobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11332">
        <property type="entry name" value="SECRETOGLOBIN FAMILY 1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11332:SF6">
        <property type="entry name" value="SECRETOGLOBIN FAMILY 1D MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01099">
        <property type="entry name" value="Uteroglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48201">
        <property type="entry name" value="Uteroglobin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51311">
        <property type="entry name" value="SCGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039933291" evidence="5">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035297478.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15681" checksum="1F8F4763EF7D9673" modified="2023-06-28" version="1">MRLSLCLLLVILAVHCYEADAAMVCPAVIKESGIFVTGSEETLRKELEKYDAPPEAVEAKLEVKRCVDSKLSTLEKLEIAKVLGRDVLEAMDAVQATNPVQHMLREQGQEKGLGRFTSDPLPMLDKPLVQRAPGNGRELGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GV72</accession>
    <name>A0A9J7GV72_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Multiple epidermal growth factor-like domains protein 11 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">Megf11</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MEGF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035300113.1">
        <property type="nucleotide sequence ID" value="XM_035444222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GV72"/>
    <dbReference type="GeneID" id="100767399"/>
    <dbReference type="KEGG" id="cge:100767399"/>
    <dbReference type="CTD" id="84465"/>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000007">
        <property type="entry name" value="multiple epidermal growth factor-like domains protein 10"/>
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        <property type="entry name" value="MULTIPLE EGF LIKE DOMAINS 11"/>
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        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
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    <keyword evidence="3 11" id="KW-0245">EGF-like domain</keyword>
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    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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    <feature type="chain" id="PRO_5039889185" evidence="14">
        <location>
            <begin position="20"/>
            <end position="1061"/>
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        <location>
            <begin position="818"/>
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            <begin position="24"/>
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            <begin position="722"/>
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            <begin position="757"/>
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            <begin position="132"/>
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    <sequence length="1061" mass="112968" checksum="441F4FE7BBC30AF9" modified="2023-06-28" version="1">MAPSTVGLLVVSFLQAALTLNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCADILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYENGDFCIRCDSEHWGPHCSNRCQCQNGALCNPITGACVCAPGFRGWRCEELCAPGTHGKGCQLPCQCHHGASCDPRTGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGTFGFRCSQRCDCHNGGQCSPATGACECEPGYKGPSCQERLCPEGLHGPGCTLPCPCDTENTISCHPVTGACTCHPGWSGHFCNESCPAGYYGNGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVPCTSGTYGPNCSSVCSCSNGGTCSPVDGSCTCQEGWQGPDCSLPCPSGTWGLNCNETCVCANGAACSPSDGSCACTPGWLGDSCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCTQSCPLCVHSSGPCHHVSGICECLPGFSGALCNQVCAGGHFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPSGFWGSACFHTCSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGHICQCQNGASCDHITGKCTCRTGFTGRHCEQRCAPGTFGYGCQQLCECMNNATCDHVTGTCYCSPGFKGIRCDQAALMMDELNPYTKISPALGAERHSVGAVTGIILLLFLVVVLLGLFAWRRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSDLSQSSSHAQCFSNASYHTLACGVPATSQASTLDRNSPTKLSNKSLDRDTAGWTPYSYVNVLDSHFQISALEARYPPEDFYIELRHLSRHNEPHSPGTCGLDRRQNTYIMDKGFKDYMKESTCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVGRCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GV86</accession>
    <name>A0A9J7GV86_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="27 28">Mevalonate kinase</fullName>
            <shortName evidence="28">MK</shortName>
            <ecNumber evidence="7 28">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">Mvk</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="32">17A/GY</strain>
            <tissue evidence="32">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26 28">Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 28">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="25 28">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 28">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 28">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="7 28"/>
    <dbReference type="RefSeq" id="XP_035299130.1">
        <property type="nucleotide sequence ID" value="XM_035443239.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035312488.1">
        <property type="nucleotide sequence ID" value="XM_035456597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GV86"/>
    <dbReference type="GeneID" id="100751653"/>
    <dbReference type="CTD" id="4598"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000119">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 28" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="10 28" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8 28" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 28 32" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 28" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="21 28" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19 28" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="24 28" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="20 28" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="23 28" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="11 28" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="29">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="30">
        <location>
            <begin position="296"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00053839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00073318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_035299130.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="46070" checksum="707C0FA1A052DA3A" modified="2023-06-28" version="1">MLSEALLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLLLRPQSNGKVSLNLPNIGIKQVWDVAGLQLLDTNFLEQGDGPAPTPEQLEKLKKVAGLPEDGVGTEGLAVLAFLYLYLAICRKQRVLPSLDIVVWSELPPGAGLGSSAAYSVCLVAALLTACENITNPLKDRDAISRWSEEDLESINKWAYEGERVIHGNPSGVDNAVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLLKFPEIVTPLLTSIDAISLECERVLGEMVAAPAPEQYLVLEELIDMNQHHLNALGVGHTSLDQLCRITAAHGLHSKLTGAGGGGCGITLLKPGETEAQRGYLCPEQQTQASNLVTAAAEAGVPRSLSNRLSPAICLKEQSLSRPSPNTATKMHAVDRDIEADTELGNDPFLDTVCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GVS2</accession>
    <name>A0A9J7GVS2_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Slc44a2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="20">17A/GY</strain>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Choline transporter.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>choline(out) + n H(+)(in) = choline(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:75463"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ethanolamine(out) + n H(+)(in) = ethanolamine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:75467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with COCH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Cell membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035299399.1">
        <property type="nucleotide sequence ID" value="XM_035443508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GVS2"/>
    <dbReference type="GeneID" id="100757777"/>
    <dbReference type="CTD" id="57153"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF34">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_035299399.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="83388" checksum="16AC6FD15D4C755F" modified="2023-06-28" version="1">MGRRINTTPPSKDPFTTEDSRFNSQPCMQFRGPDALFRSPQALDAHMAMLCRGCTDVICCVLFFLAIVGYVAVGIVAWTHGDPRKVIYPTDSQGQFCGQKGTKNENKPFLFYFNIVKCASPLVLLEFQCPTPQICVKQCPDRYLTFLNAHNSHDFEYYKQFCMPSFQNNKGVAEVLRDGDCPAVIIPSKPLFQRCFPAIHTNRGVLMVGNETTYEDGHGTRKNITELVEGAKRANMVLEARELAMQIFEDYTVSWYWIVIGLVIAMVLSLLFIILLRFLAGIMVWVMIVMVVLVLGYGIFHCYMEYSRLRGQAGSDVSLVDLGFQTDLRVYLHLRQTWMAFMIILSILEVVIILLLIFLRKRILIAIALIKEASRAVGHVMCSMLYPLVTFFLLCLCIAYWASTAVFLSTSNVAVYKIFDDTSCPLSGKTCNPETFPSVNESRQCPNGRCQFAFYGGESTYHRALLGLQIFNVFMFFWLANFVLALGQVTLAGAFASYYWAMHKPDDMPAFPLFSAFSRALRYHTGSLAFGSLILAIVQIIRVVLEYLDQRLKAAQNKFAKFLMVCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTALPLNYYWVPILTVIIGSYMIAHGFFSVYGMCVDTLFLCFCEDLERNDGSLERPYFMSPELRDILLSSQAGKQEEVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GW21</accession>
    <name>A0A9J7GW21_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein C1orf167 homolog isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CUNH1orf167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035297073.1">
        <property type="nucleotide sequence ID" value="XM_035441182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="113831460"/>
    <dbReference type="KEGG" id="cge:113831460"/>
    <dbReference type="CTD" id="111094322"/>
    <dbReference type="OrthoDB" id="9043019at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031473">
        <property type="entry name" value="DUF4684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38493">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38493:SF1">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15736">
        <property type="entry name" value="DUF4684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035297073.1"/>
        </source>
    </evidence>
    <sequence length="822" mass="92411" checksum="62F6AFD2D9BE9066" modified="2023-06-28" version="1">MPMRQAAIRSQGSVLCHRPYQVQSNLSSFCPRLAPALKDTTGQLGDPGLWQQSNLKLPAGRSQSTRAQEPFAQQSNLCFRGNASPHLRNSCLPPAGPPSHQRQTLRATDTLCLDLRLSGGLAPLDGCIWPGPRPWCASGSWAPRLVGEPLTLEDLSVCAHSQSWVSSRSSCITDHWLLDSIQHLEPVATRSRSPTCQEHPGPTHRRAHTRSSQSTPTQPWPNHPRESINLLETLRVQARLSESPNKAQSVGTSDPQAVCQKLLSRCFRAWKHLSQRHQAAAKAIALRQRQLMQKSLRVLRWVQRLRLRLQEAQLEAAWEQSAEALLAWGFQEGKPFLGKKSSHRPCLEMQVSVDTKTERCGLGSWWPTPTPTLPLSTSFFHREPWCFRAWQRFVQRGAQCRRHLAHQRVRILRVCLGQWMEMKQLQASDVTKVTQLSLYRRKAGKPVANSGSGAGEGPSQDGEDGDLRRPWNKALGILVPGTTTSYCLETVVQAQQLPQEPDPCSLWEACQRLALHRVLLLWRTRLYQHQQALRVIHWLQLIMAFPLGSLTAALSLSWVLGVPETYLPPSPSSFFQGMQKRALQHILSQWHLRAWGPEPPSSSMETMLALQPWGNSPRGEAWLGLGTSGGPLEKVQVQQTQNAVRLYRLSSSAQGPWRELAAHWGXDQSRRAVMGLWWRPLVHYFQAWCEHVRDIGVSQDHCQAFQDDLRGDLGATFASSQEACKVGPQAQDPCVAQASVLGWRSFLQECGTDRQLRKAQAWQAFAVWRVSLGQSREAQQQEGRSFQVLSPVQVALCWVPWMHDSYLGQVHQAHAAQQLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GYQ9</accession>
    <name>A0A9J7GYQ9_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Echinoderm microtubule-associated protein-like 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Eml1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035301552.1">
        <property type="nucleotide sequence ID" value="XM_035445661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GYQ9"/>
    <dbReference type="GeneID" id="100770154"/>
    <dbReference type="KEGG" id="cge:100770154"/>
    <dbReference type="CTD" id="2009"/>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000011">
        <property type="entry name" value="Echinoderm microtubule-associated protein-like 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000005">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF22">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="232"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="514"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="636"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="748"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_035301552.1"/>
        </source>
    </evidence>
    <sequence length="783" mass="86376" checksum="4E29062B0CBDC246" modified="2023-06-28" version="1">MEVSDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLGQTLPLRTTVNNGTVLPKKPSASLPSPSGSRKEMVVPVTKSINRTSSSERVSPGGRRESSGDSKGSRNRTGSTSSSSSGKKNSESKPKEPAFSPEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKAELPAKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHSDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGSHLCAVDDSNDHVLSVWDWQKEERLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGNSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRRLISWNGNYQKLHKTEIPEQFGPIRTVAEGKGNVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVGDNGRKYSRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLCTGDDFGKVHLFTYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7GZZ4</accession>
    <name>A0A9J7GZZ4_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC113835706</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC113835706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="7">17A/GY</strain>
            <tissue evidence="7">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035301780.1">
        <property type="nucleotide sequence ID" value="XM_035445889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7GZZ4"/>
    <dbReference type="GeneID" id="113835706"/>
    <dbReference type="KEGG" id="cge:113835706"/>
    <dbReference type="OrthoDB" id="9611696at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001878">
        <property type="entry name" value="Immunoglobulin heavy variable 1-4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001259">
        <property type="entry name" value="Immunoglobulin heavy variable 13-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="125"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="253"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_035301780.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43032" checksum="5C9F42CABA58A65E" modified="2023-06-28" version="1">MLTAVISDAAEGVQCEVQLVESGGGLVQPGKSLKLSFAASGFSFSDYYMNWIRQFPGKNLEWMGGIGSTGGTGYNPSLKSRISITRDTAKNQIFLQLNSVTTEDTATYYCARYTVRGSYFWFDPSQSLSLTCIVTGYSISSGYWWSWIRQHPGKGLEWMGKIDRDGDTYYNPSLKSRITMTVDTSKNQFSLRLNSVTTEDTAVYYCARGTVMELQLATLVAKVPLSLISLKSTELQRSSEHRSQDRHEKAVFPQGSVTPSDTVSTMILRISREEVGETVAGVQCEVQLVESGGGLLQPGVSLRLSCVASGFTFSSDWMGWIRQDPGKGLQWVAEINGDSSKANYAPFLKDRFTISRDNAKSILYLQMNNVKSEDTTYHCARDTRDTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H3Y8</accession>
    <name>A0A9J7H3Y8_CRIGR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM221A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Fam221a</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035304331.1">
        <property type="nucleotide sequence ID" value="XM_035448440.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_035315056.1">
        <property type="nucleotide sequence ID" value="XM_035459165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H3Y8"/>
    <dbReference type="GeneID" id="100762448"/>
    <dbReference type="CTD" id="340277"/>
    <dbReference type="OrthoDB" id="310364at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF2">
        <property type="entry name" value="PROTEIN FAM221A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035304331.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33577" checksum="1B83A6FEA88BEF69" modified="2023-06-28" version="1">MERLTLPPGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKKKVLPMRLQNRLFVSWRSPTGVDCKLVGPETLCFCTHRYKQHKTDFEKIPQQRPIALPCRVPSCQCKAYRYVPLNGTQPVRCRCKHFADQHSAAPGFTCNACSKCSGFHSCFTCGCSQPACAHDTVVETWQERLAQGKPVGQDVPYAAMGGLTGFSSLAEGYMRLDDSGIGAPSVEALEAPVSAMDHPFLRALQTPSTSAPQTLTDGNAITRIGPSTQISSVMKPEEDDMAYFERRFQERLKMEKAAKQEGKALLPPGTKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H548</accession>
    <name>A0A9J7H548_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 239-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC118239318</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="15">17A/GY</strain>
            <tissue evidence="15">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035305010.1">
        <property type="nucleotide sequence ID" value="XM_035449119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H548"/>
    <dbReference type="GeneID" id="118239318"/>
    <dbReference type="KEGG" id="cge:118239318"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000017">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_035305010.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45047" checksum="9B3061B554245350" modified="2023-06-28" version="1">MWQSISPRRNVAINFSKEEWEFLNTSQRDLYRAVMLENYSNLVSVGLSKSKPELVTCLEQNKEPWMVTIEEAEGMEPDTGMKQYKCNKCGKSFMKGSDLKVHEKIHTGKKPYKCKECGKSFTQGSTLRVHQIIHTGEKPYKCNECGMSFVKDSNLHTHQRIHTGEKPYKCNECGKSFTQVSTLQVHQRIHTGEKPYKCTECGKCFTNGSDLKVHQRIHTGEKPCKYEECGKSFTQVSTLQVHQRIHTGKKPYKCKECGKSFTQVSTLQVHQRIHTGEKAYKCTECGKSFTNGSALKVHQRIHTGEKPYKCTECGKSFTNGSKLHDHQRLHTGEKLYKCKECGKCFTTPLTLKVHQRTHTGEKTYNCKVCGKSFIKCSKLQAHQKLHKGEKRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7H7C3</accession>
    <name>A0A9J7H7C3_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein Niban 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Niban3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Niban family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035306299.1">
        <property type="nucleotide sequence ID" value="XM_035450408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7H7C3"/>
    <dbReference type="GeneID" id="100774372"/>
    <dbReference type="KEGG" id="cge:100774372"/>
    <dbReference type="CTD" id="199786"/>
    <dbReference type="OrthoDB" id="9412522at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23949">
        <property type="entry name" value="Niban-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026088">
        <property type="entry name" value="Niban-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059060">
        <property type="entry name" value="Niban_1/2/3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14392">
        <property type="entry name" value="NIBAN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14392:SF4">
        <property type="entry name" value="PROTEIN NIBAN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26086">
        <property type="entry name" value="Niban2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26089">
        <property type="entry name" value="PH_Niban2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="68"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035306299.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="65599" checksum="1D2968C7EAB199ED" modified="2023-06-28" version="1">MGARPSSPLDKRQQQQLRGQVDSLLRAFLPCYRRQLAAAVLRQISRELGPQEPAGCQLSHTKKLPRVREHQGPLTLLRGHPPQWQPTFCVLRGDGRLEWFSQKEEYESGGPPLGSAALTGYILLTSQREYLCLLDDLCPSSSGDLAQEEPLRVLEEPVSFALFLVHPFRAHLCFCARTRGAQRAWRLNLQGAIRLRATVLQRSRAPAACAFLDAVQLYRRRRGFAGGKDATLGSDAEVLSAELMRELLPGLRSQALRGLRGAGRARARACAEFLDAVHAAVLARASAGLRAFQPEKDALLAALERTVRAELEHILQQRAQRARRLQVEIRDALEACLCRMVDPQLSQLTLALLSPVEAMLGAVRTLLIRGMDRLSHHLRKNPSGTRLRREVYEFGEIPWDPELMQICYREAERNRNHLAQLAEPFGFLGMRSLVFGVQDVAQQLMADAVTTFLQLADQCLTSTLDCGQAAEQLEKVRGLVLKKFTSDSETTRWRFTRDWLLDIFWPFVWNELGVSYNLEQPEVDGDILATEGVCRDVIQGLLLQRIDGELKKILGACNRTCTRADCSVAQWNQEGVGEYLRVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HCQ1</accession>
    <name>A0A9J7HCQ1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2 variant 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC100769951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="4">17A/GY</strain>
            <tissue evidence="4">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035309831.1">
        <property type="nucleotide sequence ID" value="XM_035453940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HCQ1"/>
    <dbReference type="GeneID" id="100769951"/>
    <dbReference type="KEGG" id="cge:100769951"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="46"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_035309831.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20058" checksum="5CBED334258C6B26" modified="2023-06-28" version="1">MGQAFSKEDLFLSGITESLKIWGTRVKKKQLGSKLAATTSSGVKVPRNFQTLEELEEGQKGVGDGTVSLGLEDDEEMTLTKWTGIIIGPPRSIYENRIYSLKIECGPKYLEASPSVRFVTKVNMSCVSSSNGVVDTRATAVLAKWQKSHSIKVILQELRLLMMSKEILKLPQPTEQECYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HEA1</accession>
    <name>A0A9J7HEA1_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leukemia inhibitory factor isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Lif</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="3">17A/GY</strain>
            <tissue evidence="3">Liver</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_035308032.1">
        <property type="nucleotide sequence ID" value="XM_035452141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HEA1"/>
    <dbReference type="GeneID" id="100758301"/>
    <dbReference type="CTD" id="3976"/>
    <dbReference type="OrthoDB" id="9844600at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_035308032.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22191" checksum="4BB4D4EE1F3FC7C2" modified="2023-06-28" version="1">MGLWLFLGQRQGMAAVHTACGRSESKHLRPTPAGHEESCPVIALCWLGSPRQARRGPVSCDSGHSGLATQPRGIKYRDAPSPHPTPLLLLPVSQHHRPTRVRLCLWCGLSTSWVLSLGVGWKWGEPPATSSGRKSGGGQGEEPTPEKPQQEREAEGPNHDGVALKTGQSVQTVEGCDKHRDHEMKKLRVRSVRFPKATHPVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7HEK0</accession>
    <name>A0A9J7HEK0_CRIGR</name>
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        <recommendedName>
            <fullName evidence="7">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC100752198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="11">17A/GY</strain>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_035308930.1">
        <property type="nucleotide sequence ID" value="XM_035453039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J7HEK0"/>
    <dbReference type="GeneID" id="100752198"/>
    <dbReference type="KEGG" id="cge:100752198"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF5">
        <property type="entry name" value="PROTEIN YIPF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="9">
        <location>
            <begin position="122"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001108280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_035308930.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="28724" checksum="8346C5B55A2E15F7" modified="2023-06-28" version="1">MSGRLSTKAGEATPSQGRGSGHKRQREPGLTQIRRAACLSRRLFIILWSRTQATEQQHPSSSVPPDTFLPASYAGQLFQPASNSGYYLHSSSDDSFDEEPPLLEELGINFDHIWQKTLTVLNPMKPADGSIMNETDLTGPILFCVALGATMLMAGKAQFGYVYGMSAIGCLVIHTLLNLMSSAGVSYGCVASVLGYCLLPMVILSSCAIFFSLQGTLGTVTALLIITWCSLSASKIFISALAMEGQQLLVAYPCALFYGLFALLTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J7JAN5</accession>
    <name>A0A9J7JAN5_CRIGR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">A-kinase anchor protein SPHKAP isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Sphkap</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cricetulus griseus</name>
        <name type="common">Chinese hamster</name>
        <name type="synonym">Cricetulus barabensis griseus</name>
        <dbReference type="NCBI Taxonomy" id="10029"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Glires</taxon>
            <taxon>Rodentia</taxon>
            <taxon>Myomorpha</taxon>
            <taxon>Muroidea</taxon>
            <taxon>Cricetidae</taxon>
            <taxon>Cricetinae</taxon>
            <taxon>Cricetulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2018" name="Biotechnol. Bioeng." volume="115" first="2087" last="2100">
            <title>A reference genome of the Chinese hamster based on a hybrid assembly strategy.</title>
            <authorList>
                <person name="Rupp O."/>
                <person name="MacDonald M.L."/>
                <person name="Li S."/>
                <person name="Dhiman H."/>
                <person name="Polson S."/>
                <person name="Griep S."/>
                <person name="Heffner K."/>
                <person name="Hernandez I."/>
                <person name="Brinkrolf K."/>
                <person name="Jadhav V."/>
                <person name="Samoudi M."/>
                <person name="Hao H."/>
                <person name="Kingham B."/>
                <person name="Goesmann A."/>
                <person name="Betenbaugh M.J."/>
                <person name="Lewis N.E."/>
                <person name="Borth N."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="29704459"/>
            <dbReference type="DOI" id="10.1002/bit.26722"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2020" name="Biotechnol. Bioeng." volume="117" first="2331" last="2339">
            <title>Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.</title>
            <authorList>
                <person name="Hilliard W."/>
                <person name="MacDonald M."/>
                <person name="Lee K.H."/>
            </authorList>
            <dbReference type="PubMed" id="32410221"/>
            <dbReference type="DOI" id="10.1002/bit.27432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">17A/GY</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <strain evidence="6">17A/GY</strain>
            <tissue evidence="6">Liver</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AKAP110 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_027253195.1">
        <property type="nucleotide sequence ID" value="XM_027397394.2"/>
    </dbReference>
    <dbReference type="GeneID" id="100761697"/>
    <dbReference type="CTD" id="80309"/>
    <dbReference type="OrthoDB" id="6154436at2759"/>
    <dbReference type="Proteomes" id="UP001108280">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018292">
        <property type="entry name" value="AKAP_110_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008382">
        <property type="entry name" value="SPHK1-interactor_AKAP_110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10226">
        <property type="entry name" value="A KINASE ANCHOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10226:SF7">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN SPHKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05716">
        <property type="entry name" value="AKAP_110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor 110kDa C-terminal" evidence="4">
        <location>
            <begin position="1631"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="802"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1281"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1389"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1457"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1511"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="856"/>
            <end position="873"/>
   
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